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Sungwan Kim  (Kim S) 1 Article
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Application of the Oral Minimal Model to Korean Subjects with Normal Glucose Tolerance and Type 2 Diabetes Mellitus
Min Hyuk Lim, Tae Jung Oh, Karam Choi, Jung Chan Lee, Young Min Cho, Sungwan Kim
Diabetes Metab J. 2016;40(4):308-317.   Published online June 2, 2016
DOI: https://doi.org/10.4093/dmj.2016.40.4.308
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  • 2 Web of Science
  • 2 Crossref
AbstractAbstract PDFPubReader   
Background

The oral minimal model is a simple, useful tool for the assessment of β-cell function and insulin sensitivity across the spectrum of glucose tolerance, including normal glucose tolerance (NGT), prediabetes, and type 2 diabetes mellitus (T2DM) in humans.

Methods

Plasma glucose, insulin, and C-peptide levels were measured during a 180-minute, 75-g oral glucose tolerance test in 24 Korean subjects with NGT (n=10) and T2DM (n=14). The parameters in the computational model were estimated, and the indexes for insulin sensitivity and β-cell function were compared between the NGT and T2DM groups.

Results

The insulin sensitivity index was lower in the T2DM group than the NGT group. The basal index of β-cell responsivity, basal hepatic insulin extraction ratio, and post-glucose challenge hepatic insulin extraction ratio were not different between the NGT and T2DM groups. The dynamic, static, and total β-cell responsivity indexes were significantly lower in the T2DM group than the NGT group. The dynamic, static, and total disposition indexes were also significantly lower in the T2DM group than the NGT group.

Conclusion

The oral minimal model can be reproducibly applied to evaluate β-cell function and insulin sensitivity in Koreans.

Citations

Citations to this article as recorded by  
  • Fimasartan increases glucose‐stimulated insulin secretion in patients with type 2 diabetes and hypertension compared with amlodipine
    Ye Seul Yang, Min Hyuk Lim, Seong Ok Lee, Eun Roh, Chang Ho Ahn, Soo Heon Kwak, Young Min Cho, Sungwan Kim, Andrea Mari, Kyong Soo Park, Hye Seung Jung
    Diabetes, Obesity and Metabolism.2018; 20(7): 1670.     CrossRef
  • The Cut-off Values of Triglycerides and Glucose Index for Metabolic Syndrome in American and Korean Adolescents
    Shinje Moon, Joon-Sung Park, Youhern Ahn
    Journal of Korean Medical Science.2017; 32(3): 427.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal