- Polymeric Gene Delivery for Diabetic Treatment
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Sung Wan Kim
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Diabetes Metab J. 2011;35(4):317-326. Published online August 31, 2011
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DOI: https://doi.org/10.4093/dmj.2011.35.4.317
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Abstract
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Several polymers were used to delivery genes to diabetic animals. Polyaminobutyl glycolic acid was utilized to deliver IL-10 plasmid DNA to prevent autoimmune insulitis of non-obese diabetic (NOD) mouse. Polyethylene glycol grafted polylysine was combined with antisense glutamic acid decarboxylase (GAD) MRNA to represent GAD autoantigene expression. GLP1 and TSTA (SP-EX4) were delivered by bioreducible polymer to stop diabetic progression. Fas siRNA delivery was carried out to treat diabetic NOD mice animal.
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