Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal

Search
OPEN ACCESS

Author index

Page Path
HOME > Browse > Author index
Search
Seung Jin Han  (Han SJ) 8 Articles
Drug/Regimen
A Real-World Study of Long-Term Safety and Efficacy of Lobeglitazone in Korean Patients with Type 2 Diabetes Mellitus
Bo-Yeon Kim, Hyuk-Sang Kwon, Suk Kyeong Kim, Jung-Hyun Noh, Cheol-Young Park, Hyeong-Kyu Park, Kee-Ho Song, Jong Chul Won, Jae Myung Yu, Mi Young Lee, Jae Hyuk Lee, Soo Lim, Sung Wan Chun, In-Kyung Jeong, Choon Hee Chung, Seung Jin Han, Hee-Seok Kim, Ju-Young Min, Sungrae Kim
Diabetes Metab J. 2022;46(6):855-865.   Published online March 8, 2022
DOI: https://doi.org/10.4093/dmj.2021.0264
  • 8,495 View
  • 343 Download
  • 7 Web of Science
  • 7 Crossref
AbstractAbstract PDFPubReader   ePub   
Background
Thiazolidinediones (TZDs) have been associated with various safety concerns including weight gain, bladder cancer, and congestive heart failure (CHF). This study evaluated the efficacy and safety of lobeglitazone, a novel TZD in patients with type 2 diabetes mellitus (T2DM) in real practice.
Methods
In this non-interventional, multi-center, retrospective, and observational study conducted at 15 tertiary or secondary referral hospitals in Korea, a total of 2,228 patients with T2DM who received lobeglitazone 0.5 mg for more than 1 year were enrolled.
Results
Overall adverse events (AEs) occurred in 381 patients (17.10%) including edema in 1.97% (n=44). Cerebrovascular and cardiovascular diseases were identified in 0.81% (n=18) and 0.81% (n=18), respectively. One case of CHF was reported as an AE. Edema occurred in 1.97% (n=44) of patients. Hypoglycemia occurred in 2.47% (n=55) of patients. Fracture occurred in 1.17% (n=26) of all patients. Lobeglitazone significantly decreased HbA1c level, resulting in a mean treatment difference of -1.05%± 1.35% (P<0.001), and decreased total cholesterol, triglyceride, and low-density lipoprotein cholesterol. However, it increased high-density lipoprotein cholesterol, regardless of statin administration. The patients who received lobeglitazone 0.5 mg showed an apparent reduction in glycosylated hemoglobin (HbA1c) from baseline during the first 6 months of treatment. The HbA1c levels remained stable between months 6 and 42.
Conclusion
Lobeglitazone has long-term safety profile, good glycemic-lowering effect and long-term durability of glycemic control in real-world clinical settings.

Citations

Citations to this article as recorded by  
  • Efficacy and safety of novel thiazolidinedione lobeglitazone for managing type-2 diabetes a meta-analysis
    Deep Dutta, Saptarshi Bhattacharya, Manoj Kumar, Priyankar K. Datta, Ritin Mohindra, Meha Sharma
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2023; 17(1): 102697.     CrossRef
  • Efficacy and safety of lobeglitazone, a new Thiazolidinedione, as compared to the standard of care in type 2 diabetes mellitus: A systematic review and meta-analysis
    Shashank R. Joshi, Saibal Das, Suja Xaviar, Shambo Samrat Samajdar, Indranil Saha, Sougata Sarkar, Shatavisa Mukherjee, Santanu Kumar Tripathi, Jyotirmoy Pal, Nandini Chatterjee
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2023; 17(1): 102703.     CrossRef
  • Will lobeglitazone rival pioglitazone? A systematic review and critical appraisal
    Kalyan Kumar Gangopadhyay, Awadhesh Kumar Singh
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2023; 17(4): 102747.     CrossRef
  • Lobeglitazone

    Reactions Weekly.2023; 1948(1): 262.     CrossRef
  • Lobeglitazone, a novel thiazolidinedione, for secondary prevention in patients with ischemic stroke: a nationwide nested case-control study
    Joonsang Yoo, Jimin Jeon, Minyoul Baik, Jinkwon Kim
    Cardiovascular Diabetology.2023;[Epub]     CrossRef
  • Lobeglitazone and Its Therapeutic Benefits: A Review
    Balamurugan M, Sarumathy S, Robinson R
    Cureus.2023;[Epub]     CrossRef
  • Oldies but Goodies: Thiazolidinedione as an Insulin Sensitizer with Cardioprotection
    Eun-Hee Cho
    Diabetes & Metabolism Journal.2022; 46(6): 827.     CrossRef
Guideline/Fact Sheet
Article image
Diabetes Fact Sheets in Korea, 2020: An Appraisal of Current Status
Chan-Hee Jung, Jang Won Son, Shinae Kang, Won Jun Kim, Hun-Sung Kim, Hae Soon Kim, Mihae Seo, Hye-Jung Shin, Seong-Su Lee, Su Jin Jeong, Yongin Cho, Seung Jin Han, Hyang Mi Jang, Mira Rho, Shinbi Lee, Mihyun Koo, Been Yoo, Jung-Wha Moon, Hye Young Lee, Jae-Seung Yun, Sun Young Kim, Sung Rae Kim, In-Kyung Jeong, Ji-Oh Mok, Kun Ho Yoon
Diabetes Metab J. 2021;45(1):1-10.   Published online January 13, 2021
DOI: https://doi.org/10.4093/dmj.2020.0254
  • 26,016 View
  • 1,215 Download
  • 145 Web of Science
  • 175 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
This study aimed to investigate the recent prevalence, management, and comorbidities of diabetes among Korean adults aged ≥30 years by analyzing nationally representative data.
Methods
This study used data from the Korea National Health and Nutrition Examination Survey from 2016 to 2018, and the percentage and total number of people ≥30 years of age with diabetes and impaired fasting glucose (IFG) were estimated.
Results
In 2018, 13.8% of Korean adults aged ≥30 years had diabetes, and adults aged ≥65 years showed a prevalence rate of 28%. The prevalence of IFG was 26.9% in adults aged ≥30 years. From 2016 to 2018, 35% of the subjects with diabetes were not aware of their condition. Regarding comorbidities, 53.2% and 61.3% were obese and hypertensive, respectively, and 72% had hypercholesterolemia as defined by low-density lipoprotein cholesterol (LDL-C) ≥100 mg/dL in people with diabetes. Of the subjects with diabetes, 43.7% had both hypertension and hypercholesterolemia. With regard to glycemic control, only 28.3% reached the target level of <6.5%. Moreover, only 11.5% of subjects with diabetes met all three targets of glycosylated hemoglobin, blood pressure, and LDL-C. The percentage of energy intake from carbohydrates was higher in diabetes patients than in those without diabetes, while that from protein and fat was lower in subjects with diabetes.
Conclusion
The high prevalence and low control rate of diabetes and its comorbidities in Korean adults were confirmed. More stringent efforts are needed to improve the comprehensive management of diabetes to reduce diabetes-related morbidity and mortality.

Citations

Citations to this article as recorded by  
  • Efficacy and safety of a fixed‐dose combination of dapagliflozin and linagliptin (AJU‐A51) in patients with type 2 diabetes mellitus: A multicentre, randomized, double‐blind, parallel‐group, placebo‐controlled phase III study
    Jun Hwa Hong, Myung Jin Kim, Kyung Wan Min, Jong Chul Won, Tae Nyun Kim, Byung‐Wan Lee, Jun Goo Kang, Jae Hyeon Kim, Jung Hwan Park, Bon Jeong Ku, Chang Beom Lee, Sang Yong Kim, Ho Sang Shon, Woo Je Lee, Joong‐Yeol Park
    Diabetes, Obesity and Metabolism.2025; 27(1): 81.     CrossRef
  • 호남권 지역주민의 건강행태와 만성질환 관리현황
    선아 김, 정은 이
    Public Health Weekly Report.2024; 17(2): 46.     CrossRef
  • Variability in the association of smoking status with the prevalence of diabetes mellitus in the Korean population according to different definitions of smoking status: analysis based on the Korea National Health and Nutrition Examination Survey (2014-202
    Yechan Kyung, Young Sook Park, Mi Hyeon Jin, Hae Jeong Lee
    International Journal of Environmental Health Research.2024; 34(9): 3218.     CrossRef
  • Factors Influencing the Dietary Behavior of Patients with Type 2 Diabetes Mellitus: A Cross-sectional Study
    Sohyun Jin, Youngshin Song
    Journal of Korean Academy of Fundamentals of Nursing.2024; 31(1): 80.     CrossRef
  • Analysis of dietary behavior and intake related to glycemic control in patients with type 2 diabetes aged 30 years or older in Korea: Utilizing the 8th Korea National Health and Nutrition Examination Survey (2019–2021)
    Jin-Ah Seok, Yeon-Kyung Lee
    Nutrition Research and Practice.2024; 18(2): 239.     CrossRef
  • Effects of an Electronic Medical Records-Linked Diabetes Self-Management System on Treatment Targets in Real Clinical Practice: Retrospective, Observational Cohort Study
    So Jung Yang, Sun-Young Lim, Yoon Hee Choi, Jin Hee Lee, Kun-Ho Yoon
    Endocrinology and Metabolism.2024; 39(2): 364.     CrossRef
  • Impact of the COVID-19 Pandemic on Obesity, Metabolic Parameters and Clinical Values in the South Korean Adult Population
    Anna Kim, Eun-yeob Kim, Jaeyoung Kim
    Journal of Clinical Medicine.2024; 13(10): 2814.     CrossRef
  • Diabetic prediction and classification of risk level using ODDTADC method in big data analytics
    G. Geo Jenefer, A. J. Deepa, M. Mary Linda
    Journal of Combinatorial Optimization.2024;[Epub]     CrossRef
  • Insulin Resistance, Non-Alcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus: Clinical and Experimental Perspective
    Inha Jung, Dae-Jeong Koo, Won-Young Lee
    Diabetes & Metabolism Journal.2024; 48(3): 327.     CrossRef
  • Analysis of Factors Influencing Changes in Left Atrium and Left Ventricle Size in Adults
    Sun-Hwa Kim, Sung-Hee Yang
    Journal of Radiological Science and Technology.2024; 47(2): 125.     CrossRef
  • Impact of electronic cigarette use on the increased risk of diabetes: the Korean Community Health Survey
    Wonseok Jeong, Seungju Kim
    Epidemiology and Health.2024; : e2024029.     CrossRef
  • Information technology-supported integrated health service for older adults in long-term care settings
    Jung-Yeon Choi, Hongsoo Kim, Seungyeon Chun, Young-il Jung, Sooyoung Yoo, In-Hwan Oh, Gi-Soo Kim, Jin Young Ko, Jae-Young Lim, Minho Lee, Jongseon Lee, Kwang-il Kim
    BMC Medicine.2024;[Epub]     CrossRef
  • Precision Diabetes Education and Support Considering Patients’ Behavioral and Psychological Phenotype: A Q-Methodology Study
    EunSeok Cha, Myoung Hwan Shin, Hyunjung Lee, Hyesun Jang, Kyong Hye Joung, Hyunjin Kim, Jooseon Lee, Melissa Spezia Faulkner
    Western Journal of Nursing Research.2024; 46(8): 602.     CrossRef
  • Artificial Intelligence Applications in Diabetic Retinopathy: What We Have Now and What to Expect in the Future
    Mingui Kong, Su Jeong Song
    Endocrinology and Metabolism.2024; 39(3): 416.     CrossRef
  • Efficacy and Safety of Metformin and Atorvastatin Combination Therapy vs. Monotherapy with Either Drug in Type 2 Diabetes Mellitus and Dyslipidemia Patients (ATOMIC): Double-Blinded Randomized Controlled Trial
    Jie-Eun Lee, Seung Hee Yu, Sung Rae Kim, Kyu Jeung Ahn, Kee-Ho Song, In-Kyu Lee, Ho-Sang Shon, In Joo Kim, Soo Lim, Doo-Man Kim, Choon Hee Chung, Won-Young Lee, Soon Hee Lee, Dong Joon Kim, Sung-Rae Cho, Chang Hee Jung, Hyun Jeong Jeon, Seung-Hwan Lee, Ke
    Diabetes & Metabolism Journal.2024; 48(4): 730.     CrossRef
  • Assessing Mental Health Conditions in Women with Gestational Diabetes Compared to Healthy Pregnant Women
    Keren Grinberg, Yael Yisaschar-Mekuzas
    Healthcare.2024; 12(14): 1438.     CrossRef
  • Diabetes self‐care activities and its correlates in patients with diabetic neuropathy
    Younhee Kang, Inkyung Park
    Journal of Clinical Nursing.2024;[Epub]     CrossRef
  • Exercise improves muscle mitochondrial dysfunction-associated lipid profile under circadian rhythm disturbance
    Yu Gu, Dong-Hun Seong, Wenduo Liu, Zilin Wang, Yong Whi Jeong, Jae-Cheol Kim, Dae Ryong Kang, Rose Ji Eun Lee, Jin-Ho Koh, Sang Hyun Kim
    The Korean Journal of Physiology & Pharmacology.2024; 28(6): 515.     CrossRef
  • Trends in prescribing sodium‐glucose cotransporter 2 inhibitors for individuals with type 2 diabetes with and without cardiovascular‐renal disease in South Korea, 2015–2021
    Kyoung Hwa Ha, Soyoung Shin, EunJi Na, Dae Jung Kim
    Journal of Diabetes Investigation.2024;[Epub]     CrossRef
  • Exposure to Bisphenol A, S, and F and its Association with Obesity and Diabetes Mellitus in General Adults of Korea: Korean National Environmental Health Survey (KoNEHS) 2015–2017
    Min Kyong Moon, Min Joo Kim, Inae Lee, Sunmi Kim, Sohyeon Choi, Jeongim Park, Yoon Hee Cho, Sooyeon Hong, Jiyoung Yoo, Hyunwoong Park, Gi Jeong Cheon, Young Joo Park, Kyungho Choi
    Exposure and Health.2023; 15(1): 53.     CrossRef
  • The evolution and future of diagnostic criteria for diabetes mellitus
    Eun-Jung Rhee
    Journal of the Korean Medical Association.2023; 66(7): 409.     CrossRef
  • Efficacy of intermittent short‐term use of a real‐time continuous glucose monitoring system in non‐insulin–treated patients with type 2 diabetes: A randomized controlled trial
    Sun Joon Moon, Kyung‐Soo Kim, Woo Je Lee, Mi Yeon Lee, Robert Vigersky, Cheol‐Young Park
    Diabetes, Obesity and Metabolism.2023; 25(1): 110.     CrossRef
  • Ocular motility disorders following coronavirus disease-19 vaccination
    Kyung-Ah Park, Hyeshin Jeon, Dong Gyu Choi, Jae Ho Jung, Hyun-Jin Shin, Byung Joo Lee, Yeji Moon, Se-Youp Lee, Dong Cheol Lee, Soon Young Cho, Seong-Joon Kim, Sei Yeul Oh, Sunghyuk Moon, Shin Yeop Oh, Daye Diana Choi, Mi Young Choi, Won Jae Kim, Ungsoo Sa
    Graefe's Archive for Clinical and Experimental Ophthalmology.2023; 261(4): 1127.     CrossRef
  • Comorbidities associated with high-risk obstructive sleep apnea based on the STOP-BANG questionnaire: a nationwide population-based study
    Gene Huh, Kyoung do Han, Yong-Moon Park, Chan-Soon Park, Kyu-na Lee, Eun Young Lee, Jung-Hae Cho
    The Korean Journal of Internal Medicine.2023; 38(1): 80.     CrossRef
  • Low Skeletal Muscle Mass Accompanied by Abdominal Obesity Additively Increases the Risk of Incident Type 2 Diabetes
    Ji Eun Jun, Seung-Eun Lee, You-Bin Lee, Gyuri Kim, Sang-Man Jin, Jae Hwan Jee, Jae Hyeon Kim
    The Journal of Clinical Endocrinology & Metabolism.2023; 108(5): 1173.     CrossRef
  • Threshold dose–response association between smoking pack-years and the risk of gallbladder cancer: A nationwide cohort study
    Joo-Hyun Park, Jung Yong Hong, Kyungdo Han
    European Journal of Cancer.2023; 180: 99.     CrossRef
  • Diabetes screening in South Korea: a new estimate of the number needed to screen to detect diabetes
    Kyoung Hwa Ha, Kyung Ae Lee, Kyung-Do Han, Min Kyong Moon, Dae Jung Kim
    The Korean Journal of Internal Medicine.2023; 38(1): 93.     CrossRef
  • Momordica charantia (bitter melon) efficacy and safety on glucose metabolism in Korean prediabetes participants: a 12-week, randomized clinical study
    Bukyung Kim, Hak Sung Lee, Hye-Jin Kim, Hyolynn Lee, In-young Lee, Soyoung Ock, Sukyoung Kwon, Sang-Soo Kang, Youngsik Choi
    Food Science and Biotechnology.2023; 32(5): 697.     CrossRef
  • Dynamic changes in prevalence of type 2 diabetes along with associated factors in Bangladesh: Evidence from two national cross-sectional surveys (BDHS 2011 and BDHS 2017–18)
    Sabiha Shirin Sara, Ashis Talukder, Ka Yiu Lee, Nayan Basak, Shaharior Rahman Razu, Iqramul Haq, Chuton Deb Nath
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2023; 17(2): 102706.     CrossRef
  • Effectiveness of Non-Contact Dietary Coaching in Adults with Diabetes or Prediabetes Using a Continuous Glucose Monitoring Device: A Randomized Controlled Trial
    Yeh-Chan Ahn, Yang Seok Kim, Bukyung Kim, Jung Mi Ryu, Myoung Soo Kim, Minkyeong Kang, Jiwon Park
    Healthcare.2023; 11(2): 252.     CrossRef
  • Interactions between Bitter Taste Receptor Gene Variants and Dietary Intake Are Associated with the Incidence of Type 2 Diabetes Mellitus in Middle-Aged and Older Korean Adults
    Kyung Won Lee, Dayeon Shin
    International Journal of Molecular Sciences.2023; 24(3): 2199.     CrossRef
  • Relationship between age at menarche and metabolic diseases in Korean postmenopausal women: The Korea National Health and Nutrition Examination Survey 2016–2018
    Hyein Jung, Yeon-Ah Sung, Young Sun Hong, Do Kyeong Song, So-hyeon Hong, Hyejin Lee, Tatsuo Shimosawa
    PLOS ONE.2023; 18(1): e0280929.     CrossRef
  • Safety and Effectiveness of Empagliflozin in Korean Patients with Type 2 Diabetes Mellitus: Results from a Nationwide Post-Marketing Surveillance
    Jun Sung Moon, Nam Hoon Kim, Jin Oh Na, Jae Hyoung Cho, In-Kyung Jeong, Soon Hee Lee, Ji-Oh Mok, Nan Hee Kim, Dong Jin Chung, Jinhong Cho, Dong Woo Lee, Sun Woo Lee, Kyu Chang Won
    Diabetes & Metabolism Journal.2023; 47(1): 82.     CrossRef
  • Cumulative muscle strength and risk of diabetes: A prospective cohort study with mediation analysis
    Shanhu Qiu, Xue Cai, Yan Liang, Wenji Chen, Duolao Wang, Zilin Sun, Bo Xie, Tongzhi Wu
    Diabetes Research and Clinical Practice.2023; 197: 110562.     CrossRef
  • Hormonal Gut–Brain Signaling for the Treatment of Obesity
    Eun Roh, Kyung Mook Choi
    International Journal of Molecular Sciences.2023; 24(4): 3384.     CrossRef
  • Consistency of 1-day and 3-day average dietary intake and the relationship of dietary intake with blood glucose, hbA1c, BMI, and lipids in patients with type 2 diabetes
    DaeEun Lee, Haejung Lee, Sangeun Lee, MinJin Lee, Ah Reum Khang
    Journal of Korean Biological Nursing Science.2023; 25(1): 20.     CrossRef
  • Systematic literature review and meta-analysis of cardiovascular risk factor management in selected Asian countries
    Eric J Yeh, Ruth Bartelli Grigolon, Sarah Ramalho Rodrigues, Ana Paula A Bueno
    Journal of Comparative Effectiveness Research.2023;[Epub]     CrossRef
  • Gut Microbial Genes and Metabolism for Methionine and Branched-Chain Amino Acids in Diabetic Nephropathy
    Ji Eun Kim, Hoonsik Nam, Ji In Park, Hyunjeong Cho, Jangwook Lee, Hyo-Eun Kim, Dong Ki Kim, Kwon Wook Joo, Yon Su Kim, Bong-Soo Kim, Sunghyouk Park, Hajeong Lee, Jan Claesen
    Microbiology Spectrum.2023;[Epub]     CrossRef
  • Prevalence and associated factors of diabetes mellitus among patients with tuberculosis in South Korea from 2011 to 2018: a nationwide cohort study
    Dawoon Jeong, Jeongha Mok, Doosoo Jeon, Hee-Yeon Kang, Hee Jin Kim, Hee-Sun Kim, Jeong Mi Seo, Hongjo Choi, Young Ae Kang
    BMJ Open.2023; 13(3): e069642.     CrossRef
  • Efficacy and safety of enavogliflozin versus dapagliflozin added to metformin plus gemigliptin treatment in patients with type 2 diabetes: A double-blind, randomized, comparator-active study: ENHANCE-D study
    Kyung-Soo Kim, Kyung Ah Han, Tae Nyun Kim, Cheol-Young Park, Jung Hwan Park, Sang Yong Kim, Yong Hyun Kim, Kee Ho Song, Eun Seok Kang, Chul Sik Kim, Gwanpyo Koh, Jun Goo Kang, Mi Kyung Kim, Ji Min Han, Nan Hee Kim, Ji Oh Mok, Jae Hyuk Lee, Soo Lim, Sang S
    Diabetes & Metabolism.2023; 49(4): 101440.     CrossRef
  • Impact of abdominal obesity on the risk of glioma development in patients with diabetes: A nationwide population-based cohort study in Korea
    Hyunji Sang, Yun Kyung Cho, Kyungdo Han, Eun Hee Koh, Sandar Tin Tin
    PLOS ONE.2023; 18(3): e0283023.     CrossRef
  • Associations Between Modifiable Risk Factors and Changes in Glycemic Status Among Individuals With Prediabetes
    Salma Nabila, Ji-Eun Kim, Jaesung Choi, JooYong Park, Aesun Shin, Sang-Ah Lee, Jong-koo Lee, Daehee Kang, Ji-Yeob Choi
    Diabetes Care.2023; 46(3): 535.     CrossRef
  • Effect of diabetes-specific oral nutritional supplements with allulose on weight and glycemic profiles in overweight or obese type 2 diabetic patients
    Jihye Tak, Minkyung Bok, Hyunkyung Rho, Ju Hyun Park, Yunsook Lim, Suk Chon, Hyunjung Lim
    Nutrition Research and Practice.2023; 17(2): 241.     CrossRef
  • The effects of hemp seed consumption on depression, anxiety and cognitive improvement based on machine learning
    Jung Jea-Bum, Cho Yong-Won , Kim Sang-Yub , Chung Soo-Yeon , Han Kyung-Hoon , Ham Byung-Joo , Han Sung-Hee
    Archives of Food and Nutritional Science.2023; 7(1): 032.     CrossRef
  • Development and Adaptability of Smartphone-based Dietary Coaching Program for Patients Undergoing Diabetes and Prediabetes with Continuous Glucose Monitoring Device
    Myoung Soo Kim, Jung Mi Ryu, Minkyeong Kang, Jiwon Park, Yeh Chan Ahn, Yang Seok Kim
    Journal of Health Informatics and Statistics.2023; 48(1): 36.     CrossRef
  • Risk of Diabetic Complications in Type 2 Diabetes Patients with Dementia: A Population-Based Study Using National Health Insurance Claims Data
    Eun Sik Jeong, Ah-Young Kim, Hye-Young Kang
    Drug Targets and Therapeutics.2023; 2(1): 49.     CrossRef
  • Type 2 Diabetes Mellitus- and Complication-Related Risk of Nontuberculous Mycobacterial Disease in a South Korean Cohort
    Da Som Jeon, Seonok Kim, Mi Ae Kim, Yong Pil Chong, Tae Sun Shim, Chang Hee Jung, Ye-Jee Kim, Kyung-Wook Jo, Paschalis Vergidis, Byung Woo Jhun
    Microbiology Spectrum.2023;[Epub]     CrossRef
  • Association of advanced chronic kidney disease with diabetic retinopathy severity in older patients with diabetes: a retrospective cross-sectional study
    Geun Woo Lee, Chul Ho Lee, Seong Gyu Kim
    Journal of Yeungnam Medical Science.2023; 40(2): 146.     CrossRef
  • RELATIVE RISK OF DIABETES MELLITUS AMONG OBESE POPULATION
    Umair Khalid, Khuram Chaudry, Hina Khuram
    Pakistan Journal of Rehabilitation.2023; 12(1): 93.     CrossRef
  • Public–Private Partnership: Participants’ Experiences of the Web-Based Registration-and-Management System for Patients with Hypertension and Diabetes Mellitus
    Seonah Lee, Nanyoung Song, Suhyun Kim
    Healthcare.2023; 11(9): 1297.     CrossRef
  • Anti-Hyperglycemic Effects of Fermented Mealworm Extract on Type 2 Diabetic Mice
    Hae-In Lee, Asli Turkyilmaz, Mi-Kyung Lee
    Journal of the Korean Society of Food Science and Nutrition.2023; 52(4): 431.     CrossRef
  • A Study on Changes in Nutritional and Blood Conditions Before and After Consumption of Diabetic Soymilk in Elderly Women with Diabetes
    Hyo-Jeong Hwang, Soon-Hee Park, Seon-Young Park, Soo-Rin Ahn, Su-Jin Park, Yoo-Jin Lee, Kwang-Jin Chon, Chung-Hwa Song, Dae-Gyun Moon, Kyung-Ok Shin
    Journal of the Korean Society of Food Science and Nutrition.2023; 52(4): 341.     CrossRef
  • Developing a Classification Algorithm for Prediabetes Risk Detection From Home Care Nursing Notes
    Eunjoo Jeon, Aeri Kim, Jisoo Lee, Hyunsook Heo, Hana Lee, Kyungmi Woo
    CIN: Computers, Informatics, Nursing.2023; 41(7): 539.     CrossRef
  • Chronic disease management program applied to type 2 diabetes patients and prevention of diabetic complications: a retrospective cohort study using nationwide data
    Min Kyung Hyun, Jang Won Lee, Seung-Hyun Ko
    BMC Public Health.2023;[Epub]     CrossRef
  • Peripheral neuropathy and neuropathic pain in the elderly
    Je-Young Shin
    Journal of Geriatric Neurology.2023; 2(1): 7.     CrossRef
  • Cholecystectomy Increases the Risk of Type 2 Diabetes in the Korean Population
    Ji Hye Huh, Kyong Joo Lee, Yun Kyung Cho, Shinje Moon, Yoon Jung Kim, Eun Roh, Kyung-do Han, Dong Hee Koh, Jun Goo Kang, Seong Jin Lee, Sung-Hee Ihm
    Annals of Surgery.2023; 278(2): e264.     CrossRef
  • A Novel Salivary Sensor with Integrated Au Electrodes and Conductivity Meters for Screening of Diabetes
    Chen-Wei Lin, Yuan-Hsiung Tsai, Yun-Shing Peng, Jen-Tsung Yang, Yen-Pei Lu, Mei-Yen Chen, Chun-Wu Tung
    Biosensors.2023; 13(7): 702.     CrossRef
  • Pharmacokinetic Comparison Between a Fixed‐Dose Combination of Empagliflozin L‐Proline/Metformin and Empagliflozin/Metformin in Healthy Korean Subjects
    HyunJoon Lee, Jae‐Yong Chung, Kyung‐Sang Yu, Shin‐Jung Park, Soyoung Lee
    Clinical Pharmacology in Drug Development.2023; 12(12): 1156.     CrossRef
  • Comparisons of the prediction models for undiagnosed diabetes between machine learning versus traditional statistical methods
    Seong Gyu Choi, Minsuk Oh, Dong–Hyuk Park, Byeongchan Lee, Yong-ho Lee, Sun Ha Jee, Justin Y. Jeon
    Scientific Reports.2023;[Epub]     CrossRef
  • Comparison of therapeutic efficacy and safety of sitagliptin, dapagliflozin, or lobeglitazone adjunct therapy in patients with type 2 diabetes mellitus inadequately controlled on sulfonylurea and metformin: Third agent study
    Jun Hwa Hong, Jun Sung Moon, Kayeon Seong, Soo Lim
    Diabetes Research and Clinical Practice.2023; 203: 110872.     CrossRef
  • Predicting micropollutant fate during wastewater treatment using refined classical kinetic model based on quantitative monitoring in multi-metropolitan regions of South Korea
    Sung Ho Chae, Seung Ji Lim, Mingizem Gashaw Seid, Wondesen Workneh Ejerssa, Aseom Son, Heejong Son, Sangki Choi, Woongbae Lee, Yunho Lee, Seok Won Hong
    Water Research.2023; 245: 120627.     CrossRef
  • Intake of Fruit and Glycemic Control in Korean Patients with Diabetes Mellitus Using the Korea National Health and Nutrition Examination Survey
    Eunju Yoon, Ji Cheol Bae, Sunghwan Suh
    Endocrinology and Metabolism.2023; 38(5): 538.     CrossRef
  • Diabetes Mellitus in the Elderly Adults in Korea: Based on Data from the Korea National Health and Nutrition Examination Survey 2019 to 2020
    Seung-Hyun Ko, Kyung Do Han, Yong-Moon Park, Jae-Seung Yun, Kyuho Kim, Jae-Hyun Bae, Hyuk-Sang Kwon, Nan-Hee Kim
    Diabetes & Metabolism Journal.2023; 47(5): 643.     CrossRef
  • Lower HbA1C of glycemic control is associated with higher risk of depressive symptoms in elderly with type 2 diabetes mellitus–A Nationwide Community-based study
    Yen-Tze Liu, Wan-Hui Wu, Wei-Ting Tseng, Hsien-Chih Lin, Ming-Shiang Wu, Pei-Fen Chen, I-Chien Wu
    Journal of Psychosomatic Research.2023; 174: 111492.     CrossRef
  • Association between HbA1c and hearing loss: a tertiary care center-based study
    Hyun Jin Lee, Sung Goo Yoo, Sun Jung Lee, Jae Sang Han, In Young Choi, Kyoung Ho Park
    Scientific Reports.2023;[Epub]     CrossRef
  • The Relationship between Alcohol Consumption and Diabetes in Korean Adults
    Gi Tae Kim, Jae Woong Sull
    Biomedical Science Letters.2023; 29(3): 159.     CrossRef
  • Classification and prediction of the effects of nutritional intake on diabetes mellitus using artificial neural network sensitivity analysis: 7th Korea National Health and Nutrition Examination Survey
    Kyungjin Chang, Songmin Yoo, Simyeol Lee
    Nutrition Research and Practice.2023; 17(6): 1255.     CrossRef
  • Changes in Soluble Serum CD81 Concentration during an Oral Glucose Tolerance Test in Patients with Diabetes Mellitus and Individuals with Normal Glucose Tolerance
    Seon Mee Kang, Jun Choul Lee, Bon Jeong Ku
    Diagnostics.2023; 13(23): 3500.     CrossRef
  • Association between diabetes mellitus and cause of death in patients with tuberculosis: A Korean nationwide cohort study
    Se Hyun Kwak, Dawoon Jeong, Jeongha Mok, Doosoo Jeon, Hee-Yeon Kang, Hee Jin Kim, Hee-Sun Kim, Hongjo Choi, Young Ae Kang, Frederick Quinn
    PLOS ONE.2023; 18(12): e0295556.     CrossRef
  • The development and effects of a nursing education program for hyperglycemia patient care using standardized patients for nursing students
    Jin Lee, Pok Ja Oh
    The Journal of Korean Academic Society of Nursing Education.2023; 29(4): 427.     CrossRef
  • Position Statement on the Appropriateness and Significance of Adding the Glycated Hemoglobin Test to the National Health Examination
    Ji Hye Kim, Dae Jung Kim, Jaehyun Kim, Sangjoon Park, Kyunghoon Lee, Jun Goo Kang, Eu Jeong Ku, Su Kyoung Kwon, Won Jun Kim, Young Sang Lyu, Jang Won Son, Young Sil Eom, Kyung Ae Lee, Jeongrim Lee, Jung Min Lee, Jung Hwa Lee, Jung Hwa Jung, Hochan Cho, Da
    The Journal of Korean Diabetes.2023; 24(4): 178.     CrossRef
  • An association between socioeconomic status and preventive screening for diabetic eye and kidney complications among individuals with type 2 diabetes
    Changwoo Shon, Jongnam Hwang
    Korean Journal of Health Education and Promotion.2023; 40(5): 27.     CrossRef
  • Increased risk of cancer and cancer-related mortality in middle-aged Korean women with prediabetes and diabetes: a population-based study
    Thi Xuan Mai Tran, Soyeoun Kim, Huiyeon Song, Boyoung Park
    Epidemiology and Health.2023; 45: e2023080.     CrossRef
  • Diabetes self-management education
    Ibironke Cecilia OJO, Elizabeth Olufunmilayo OJO, Simeo Kayode OLUBIYI
    Journal of Integrative Nursing.2023; 5(2): 93.     CrossRef
  • Relationships between fasting glucose levels, lifestyle factors, and metabolic parameters in Korean adults without diagnosis of diabetes mellitus
    Seo Young Kang, Young Sik Kim
    Journal of Diabetes.2022; 14(1): 52.     CrossRef
  • Exposure to polycyclic aromatic hydrocarbons and volatile organic compounds is associated with a risk of obesity and diabetes mellitus among Korean adults: Korean National Environmental Health Survey (KoNEHS) 2015–2017
    Inae Lee, Hyunwoong Park, Min Joo Kim, Sunmi Kim, Sohyeon Choi, Jeongim Park, Yoon Hee Cho, Sooyeon Hong, Jiyoung Yoo, Gi Jeong Cheon, Kyungho Choi, Young Joo Park, Min Kyong Moon
    International Journal of Hygiene and Environmental Health.2022; 240: 113886.     CrossRef
  • Trends in intake and sources of dietary protein in Korean adults, 1998–2018
    Kyung Won Lee, Dayeon Shin
    British Journal of Nutrition.2022; 128(8): 1595.     CrossRef
  • Psychometric Properties of the Korean Version of the Perceived Therapeutic Efficacy Scale for Physical Activity in Adults With Type 2 Diabetes
    Moonsun Kim, Chun-Ja Kim, Dae Jung Kim, Elizabeth A. Schlenk
    The Science of Diabetes Self-Management and Care.2022; 48(1): 11.     CrossRef
  • Risk factors for hypertension and diabetes comorbidity in a Korean population: A cross-sectional study
    Jeong Hee Chi, Bum Ju Lee, Masaki Mogi
    PLOS ONE.2022; 17(1): e0262757.     CrossRef
  • Muscle strength and prediabetes progression and regression in middle‐aged and older adults: a prospective cohort study
    Shanhu Qiu, Xue Cai, Yang Yuan, Bo Xie, Zilin Sun, Duolao Wang, Tongzhi Wu
    Journal of Cachexia, Sarcopenia and Muscle.2022; 13(2): 909.     CrossRef
  • Effects of Teneligliptin on HbA1c levels, Continuous Glucose Monitoring-Derived Time in Range and Glycemic Variability in Elderly Patients with T2DM (TEDDY Study)
    Ji Cheol Bae, Soo Heon Kwak, Hyun Jin Kim, Sang-Yong Kim, You-Cheol Hwang, Sunghwan Suh, Bok Jin Hyun, Ji Eun Cha, Jong Chul Won, Jae Hyeon Kim
    Diabetes & Metabolism Journal.2022; 46(1): 81.     CrossRef
  • Effect of Combined Treatment with Catechin and Quercetin on Hepatic Glucose Metabolism in Diabetic Rats
    Byoung Rai Lee, Pyoung Sim Park
    Journal of the Korean Society of Food Science and Nutrition.2022; 51(1): 12.     CrossRef
  • Efficacy and Safety of Treatment with Quadruple Oral Hypoglycemic Agents in Uncontrolled Type 2 Diabetes Mellitus: A Multi-Center, Retrospective, Observational Study (Diabetes Metab J 2021;45:675-83)
    Tae Jung Oh
    Diabetes & Metabolism Journal.2022; 46(1): 160.     CrossRef
  • East Asian perspectives in metabolic and bariatric surgery
    Tae Jung Oh, Hyuk‐Joon Lee, Young Min Cho
    Journal of Diabetes Investigation.2022; 13(5): 756.     CrossRef
  • Substitution of Carbohydrates for Fats and Risk of Type 2 Diabetes among Korean Middle-Aged Adults: Findings from the Korean Genome and Epidemiology Study
    Hye-Ah Lee, Hyesook Park
    Nutrients.2022; 14(3): 654.     CrossRef
  • Comparison of Health Outcomes by Care Provider Type for Newly Diagnosed Mild Type 2 Diabetes Patients in South Korea: A Retrospective Cohort Study
    Hee-Chung Kang, Jae-Seok Hong
    Healthcare.2022; 10(2): 334.     CrossRef
  • A deep learning model for screening type 2 diabetes from retinal photographs
    Jae-Seung Yun, Jaesik Kim, Sang-Hyuk Jung, Seon-Ah Cha, Seung-Hyun Ko, Yu-Bae Ahn, Hong-Hee Won, Kyung-Ah Sohn, Dokyoon Kim
    Nutrition, Metabolism and Cardiovascular Diseases.2022; 32(5): 1218.     CrossRef
  • Rheological, textural, and functional characteristics of 3D-printed cheesecake containing guava leaf, green tea, and barley sprout powders
    Ye-Eun Park, Jeong Kim, Hyun Woo Kim, Jiyeon Chun
    Food Bioscience.2022; 47: 101634.     CrossRef
  • The Influence of Obesity and Metabolic Health on Vascular Health
    Eun-Jung Rhee
    Endocrinology and Metabolism.2022; 37(1): 1.     CrossRef
  • Osteoporosis or fracture risk associated with thiazolidinedione and proton pump inhibitor co‐administration in patients with type 2 diabetes mellitus
    Miyoung Ock, Sera Lee, Hyunah Kim
    Journal of Clinical Pharmacy and Therapeutics.2022; 47(7): 1028.     CrossRef
  • Differences in the gut microbiome composition of Korean children and adult samples based on different DNA isolation kits
    Changyoon Baek, Woo Jin Kim, JaeWoo Moon, Seo Yoon Moon, Wonsub Kim, Hae-Jin Hu, Junhong Min, Jonghoon Choi
    PLOS ONE.2022; 17(3): e0264291.     CrossRef
  • Association between Physical Exercise and Glycated Hemoglobin Levels in Korean Patients Diagnosed with Diabetes
    Il Yun, Hye Jin Joo, Yu Shin Park, Eun-Cheol Park
    International Journal of Environmental Research and Public Health.2022; 19(6): 3280.     CrossRef
  • Editorial: Management of Diabetes and its Complications: A Focus on Endothelial Dysfunction
    Shanhu Qiu, Jianhua Ma, Tongzhi Wu
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • The effect of long working hours on developing type 2 diabetes in adults with prediabetes: The Kangbuk Samsung Cohort Study
    Eunhye Seo, Yesung Lee, Eunchan Mun, Dae Hoon Kim, Youshik Jeong, Jaehong Lee, Jinsook Jeong, Woncheol Lee
    Annals of Occupational and Environmental Medicine.2022;[Epub]     CrossRef
  • GLP-1 receptor agonists in diabetic kidney disease: current evidence and future directions
    Ji Hee Yu, So Young Park, Da Young Lee, Nan Hee Kim, Ji A Seo
    Kidney Research and Clinical Practice.2022; 41(2): 136.     CrossRef
  • Prevalence of Type 2 Diabetes Mellitus among Korean Children, Adolescents, and Adults Younger than 30 Years: Changes from 2002 to 2016
    Yong Hee Hong, In-Hyuk Chung, Kyungdo Han, Sochung Chung
    Diabetes & Metabolism Journal.2022; 46(2): 297.     CrossRef
  • Synergistic association between underweight and type 2 diabetes on the development of laryngeal cancer: a national population-based retrospective cohort study
    Oh. Hyeong Lee, Yong-Moon Park, Seung-Hyun Ko, Kyuna Lee, Yeonji Kim, Kyungdo Han, Jung-Hae Cho
    BMC Cancer.2022;[Epub]     CrossRef
  • Efficacy of Geumguesingi-hwan (jinkuishenqi-wan, kinkijinki-gan) in decreasing blood glucose levels in patients with uncomplicated type 2 diabetes
    Hyun-Jin Choi, Ji-Soo Baek, Cheon-Hoo Jeon, Seon-Mi Shin, Chung-Sik Cho
    Medicine.2022; 101(12): e29079.     CrossRef
  • Effect of Motivational Interviewing Training on Diabetes Educators’ Counseling Skills and Self-Efficacy
    Sung-Chul Lim
    The Journal of Korean Diabetes.2022; 23(1): 57.     CrossRef
  • Management Status of Patients with Type 2 Diabetes Mellitus at General Hospitals in Korea: A 5-Year Follow-Up Study
    Jin Hee Jung, Jung Hwa Lee, Hyang Mi Jang, Young Na, Hee Sun Choi, Yeon Hee Lee, Yang Gyo Kang, Na Rae Kim, Jeong Rim Lee, Bok Rye Song, Kang Hee Sim
    The Journal of Korean Diabetes.2022; 23(1): 64.     CrossRef
  • Korean naked waxy barley (saechalssal) extract reduces blood glucose in diabetic mice by modulating the PI3K-Akt-GSK3β pathway
    Ju Ri Ham, Young-Jin Son, Yongjin Lee, Hyun-Jin Lee, Jiyoung Yeo, Mi Ja Lee, Mi-Kyung Lee
    Biomedicine & Pharmacotherapy.2022; 150: 112976.     CrossRef
  • Cumulative Exposure to High γ-Glutamyl Transferase Level and Risk of Diabetes: A Nationwide Population-Based Study
    Ji-Yeon Park, Kyungdo Han, Hun-Sung Kim, Jae-Hyoung Cho, Kun-Ho Yoon, Mee Kyoung Kim, Seung-Hwan Lee
    Endocrinology and Metabolism.2022; 37(2): 272.     CrossRef
  • Suicide Risk in Patients With Diabetes Varies by the Duration of Diabetes: The Korea National Health and Nutrition Examination Survey (2019)
    Young-Chan Kim, Yoo Hyun Um, Sung-Min Kim, Tae-Won Kim, Ho-Jun Seo, Seung-Chul Hong, Jong-Hyun Jeong
    Psychiatry Investigation.2022; 19(4): 326.     CrossRef
  • Gene‐environment interaction in type 2 diabetes in Korean cohorts: Interaction of a type 2 diabetes polygenic risk score with triglyceride and cholesterol on fasting glucose levels
    Ji Eun Lim, Ji‐one Kang, Tae‐Woong Ha, Hae‐Un Jung, Dong Jun Kim, Eun Ju Baek, Han Kyul Kim, Ju Yeon Chung, Sang Youl Rhee, Mi Kyung Kim, Yeon‐Jung Kim, Taesung Park, Bermseok Oh
    Genetic Epidemiology.2022; 46(5-6): 285.     CrossRef
  • The predictive value of resting heart rate in identifying undiagnosed diabetes in Korean adults: Korea National Health and Nutrition Examination Survey
    Dong-Hyuk Park, Wonhee Cho, Yong-Ho Lee, Sun Ha Jee, Justin Y. Jeon
    Epidemiology and Health.2022; 44: e2022009.     CrossRef
  • Experiences of Sleep Problems Among Older Korean Immigrants
    Yeonsu Song, Gery W. Ryan, Diane Lee, Haesook Kim, Jennifer L. Martin, B. Josea Kramer, Ron D. Hays, Sarah E. Choi
    Research in Gerontological Nursing.2022; 15(4): 193.     CrossRef
  • Current Status of Low-Density Lipoprotein Cholesterol Target Achievement in Patients with Type 2 Diabetes Mellitus in Korea Compared with Recent Guidelines
    Soo Jin Yun, In-Kyung Jeong, Jin-Hye Cha, Juneyoung Lee, Ho Chan Cho, Sung Hee Choi, SungWan Chun, Hyun Jeong Jeon, Ho-Cheol Kang, Sang Soo Kim, Seung-Hyun Ko, Gwanpyo Koh, Su Kyoung Kwon, Jae Hyuk Lee, Min Kyong Moon, Junghyun Noh, Cheol-Young Park, Sung
    Diabetes & Metabolism Journal.2022; 46(3): 464.     CrossRef
  • Diabetes Fact Sheet in Korea 2021
    Jae Hyun Bae, Kyung-Do Han, Seung-Hyun Ko, Ye Seul Yang, Jong Han Choi, Kyung Mook Choi, Hyuk-Sang Kwon, Kyu Chang Won
    Diabetes & Metabolism Journal.2022; 46(3): 417.     CrossRef
  • Effect of Carbohydrate-Restricted Diets and Intermittent Fasting on Obesity, Type 2 Diabetes Mellitus, and Hypertension Management: Consensus Statement of the Korean Society for the Study of Obesity, Korean Diabetes Association, and Korean Society of Hype
    Jong Han Choi, Yoon Jeong Cho, Hyun-Jin Kim, Seung-Hyun Ko, Suk Chon, Jee-Hyun Kang, Kyoung-Kon Kim, Eun Mi Kim, Hyun Jung Kim, Kee-Ho Song, Ga Eun Nam, Kwang Il Kim
    Diabetes & Metabolism Journal.2022; 46(3): 355.     CrossRef
  • Exercise, Mitohormesis, and Mitochondrial ORF of the 12S rRNA Type-C (MOTS-c)
    Tae Kwan Yoon, Chan Hee Lee, Obin Kwon, Min-Seon Kim
    Diabetes & Metabolism Journal.2022; 46(3): 402.     CrossRef
  • Effect of carbohydrate-restricted diets and intermittent fasting on obesity, type 2 diabetes mellitus, and hypertension management: consensus statement of the Korean Society for the Study of obesity, Korean Diabetes Association, and Korean Society of Hype
    Jong Han Choi, Yoon Jeong Cho, Hyun-Jin Kim, Seung-Hyun Ko, Suk Chon, Jee-Hyun Kang, Kyoung-Kon Kim, Eun Mi Kim, Hyun Jung Kim, Kee-Ho Song, Ga Eun Nam, Kwang Il Kim
    Clinical Hypertension.2022;[Epub]     CrossRef
  • A double‐blind, Randomized controlled trial on glucose‐lowering EFfects and safety of adding 0.25 or 0.5 mg lobeglitazone in type 2 diabetes patients with INadequate control on metformin and dipeptidyl peptidase‐4 inhibitor therapy: REFIND study
    Soree Ryang, Sang Soo Kim, Ji Cheol Bae, Ji Min Han, Su Kyoung Kwon, Young Il Kim, Il Seong Nam‐Goong, Eun Sook Kim, Mi‐kyung Kim, Chang Won Lee, Soyeon Yoo, Gwanpyo Koh, Min Jeong Kwon, Jeong Hyun Park, In Joo Kim
    Diabetes, Obesity and Metabolism.2022; 24(9): 1800.     CrossRef
  • Association of prediabetes with death and diabetic complications in older adults: the pros and cons of active screening for prediabetes
    Giwoong Choi, Hojun Yoon, Hyun Ho Choi, Kyoung Hwa Ha, Dae Jung Kim
    Age and Ageing.2022;[Epub]     CrossRef
  • Recent information on test utilization and intraindividual change in anti-glutamic acid decarboxylase antibody in Korea: a retrospective study
    Rihwa Choi, Wonseo Park, Gayoung Chun, Jiwon Lee, Sang Gon Lee, Eun Hee Lee
    BMJ Open Diabetes Research & Care.2022; 10(3): e002739.     CrossRef
  • Correlation of advanced glycation end products and heme oxygenase-1 in Korean diabetic patients
    Ha-Neul Choi, Da-Hye Koo, Jung-Eun Yim
    Journal of Nutrition and Health.2022; 55(3): 348.     CrossRef
  • The Impact of the Association between Cancer and Diabetes Mellitus on Mortality
    Sung-Soo Kim, Hun-Sung Kim
    Journal of Personalized Medicine.2022; 12(7): 1099.     CrossRef
  • Development and implementation of patient-level prediction models of end-stage renal disease for type 2 diabetes patients using fast healthcare interoperability resources
    San Wang, Jieun Han, Se Young Jung, Tae Jung Oh, Sen Yao, Sanghee Lim, Hee Hwang, Ho-Young Lee, Haeun Lee
    Scientific Reports.2022;[Epub]     CrossRef
  • Optical-fibre characteristics based on Fano resonances and sensor application in blood glucose detection
    Jun Zhu, Jinguo Yin
    Optics Express.2022; 30(15): 26749.     CrossRef
  • Effect of Carbohydrate-Restricted Diets and Intermittent Fasting on Obesity, Type 2 Diabetes Mellitus, and Hypertension Management: Consensus Statement of the Korean Society for the Study of Obesity, Korean Diabetes Association, and Korean Society of Hype
    Jong Han Choi, Yoon Jeong Cho, Hyun-Jin Kim, Seung-Hyun Ko, Suk Chon, Jee-Hyun Kang, Kyoung-Kon Kim, Eun Mi Kim, Hyun Jung Kim, Kee-Ho Song, Ga Eun Nam, Kwang Il Kim
    Journal of Obesity & Metabolic Syndrome.2022; 31(2): 100.     CrossRef
  • Maintaining Physical Activity Is Associated with Reduced Major Adverse Cardiovascular Events in People Newly Diagnosed with Diabetes
    Duhoe Kim, Jaehun Seo, Kyoung Hwa Ha, Dae Jung Kim
    Journal of Obesity & Metabolic Syndrome.2022; 31(2): 187.     CrossRef
  • Prevalence of Diabetic Retinopathy in Undiagnosed Diabetic Patients: A Nationwide Population-Based Study
    Han Na Jang, Min Kyong Moon, Bo Kyung Koo
    Diabetes & Metabolism Journal.2022; 46(4): 620.     CrossRef
  • Reproductive Life Span and Severe Hypoglycemia Risk in Postmenopausal Women with Type 2 Diabetes Mellitus
    Soyeon Kang, Yong-Moon Park, Dong Jin Kwon, Youn-Jee Chung, Jeong Namkung, Kyungdo Han, Seung-Hyun Ko
    Diabetes & Metabolism Journal.2022; 46(4): 578.     CrossRef
  • Advanced Glycation End Products and Their Effect on Vascular Complications in Type 2 Diabetes Mellitus
    Jeongmin Lee, Jae-Seung Yun, Seung-Hyun Ko
    Nutrients.2022; 14(15): 3086.     CrossRef
  • The Association of Pachydrusen Characteristics with Choroidal Thickness and Patient’s Age in Polypoidal Choroidal Vasculopathy versus Central Serous Chorioretinopathy
    Young Ho Kim, Yoo-Ri Chung, Chungwoon Kim, Kihwang Lee, Won Ki Lee
    International Journal of Molecular Sciences.2022; 23(15): 8353.     CrossRef
  • Experiences of Using Wearable Continuous Glucose Monitors in Adults With Diabetes: A Qualitative Descriptive Study
    Hee Sun Kang, Hyang Rang Park, Chun-Ja Kim, Savitri Singh-Carlson
    The Science of Diabetes Self-Management and Care.2022; 48(5): 362.     CrossRef
  • Prediction Model for Hypertension and Diabetes Mellitus Using Korean Public Health Examination Data (2002–2017)
    Yong Whi Jeong, Yeojin Jung, Hoyeon Jeong, Ji Hye Huh, Ki-Chul Sung, Jeong-Hun Shin, Hyeon Chang Kim, Jang Young Kim, Dae Ryong Kang
    Diagnostics.2022; 12(8): 1967.     CrossRef
  • Recent Increases in Influenza-Related Hospitalizations, Critical Care Resource Use, and In-Hospital Mortality: A 10-Year Population-Based Study in South Korea
    Tae Hwa Hong, Hyung Seok Lee, Nam-Eun Kim, Kyu Jin Lee, Yong Kyun Kim, Jung Nam An, Joo-Hee Kim, Hyung Won Kim, Sunghoon Park
    Journal of Clinical Medicine.2022; 11(16): 4911.     CrossRef
  • Clinical and economic impact of changing reimbursement criteria for statin treatment among patients with type 2 diabetes mellitus in South Korea
    Siin Kim, Kyungseon Choi, Ji-yool Kim, Hae Sun Suh
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • Experience of Elderly Korean Women with Diabetes and Multimorbidity in Elderly Couple Households: A Qualitative Study
    Oksoo Kim, Hyunju Dan
    Healthcare.2022; 10(9): 1675.     CrossRef
  • Long-Term Changes in HbA1c According to Blood Glucose Control Status During the First 3 Months After Visiting a Tertiary University Hospital
    Hyunah Kim, Da Young Jung, Seung-Hwan Lee, Jae-Hyoung Cho, Hyeon Woo Yim, Hun-Sung Kim
    Journal of Korean Medical Science.2022;[Epub]     CrossRef
  • Sex and Diet-Related Disparities in Low Handgrip Strength among Young and Middle-Aged Koreans: Findings Based on the Korea National Health and Nutrition Examination Survey (KNHANES) from 2014 to 2017
    Inhye Kim, Kumhee Son, Su Jin Jeong, Hyunjung Lim
    Nutrients.2022; 14(18): 3816.     CrossRef
  • Rising Incidence of Diabetes in Young Adults in South Korea: A National Cohort Study
    Hyun Ho Choi, Giwoong Choi, Hojun Yoon, Kyoung Hwa Ha, Dae Jung Kim
    Diabetes & Metabolism Journal.2022; 46(5): 803.     CrossRef
  • Analysis of the Association between Metabolic Syndrome and Renal Function in Middle-Aged Patients with Diabetes
    Yoonjin Park, Su Jung Lee
    International Journal of Environmental Research and Public Health.2022; 19(18): 11832.     CrossRef
  • Exploring the risk factors of impaired fasting glucose in middle-aged population living in South Korean communities by using categorical boosting machine
    Haewon Byeon
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Body mass index and stroke risk among patients with diabetes mellitus in Korea
    Do Kyeong Song, Young Sun Hong, Yeon-Ah Sung, Hyejin Lee, Tariq Jamal Siddiqi
    PLOS ONE.2022; 17(9): e0275393.     CrossRef
  • Low relative hand grip strength is associated with a higher risk for diabetes and impaired fasting glucose among the Korean population
    Min Jin Lee, Ah Reum Khang, Dongwon Yi, Yang Ho Kang, Giacomo Pucci
    PLOS ONE.2022; 17(10): e0275746.     CrossRef
  • Association of Glycosylated Hemoglobin Level and Cancer-Related Mortality in Patients without Diabetes
    Tae Kyung Yoo, Mi Yeon Lee, Sul A. Lee, Eun Sun Cheong, Mi Hae Seo, Ki Chul Sung
    Journal of Clinical Medicine.2022; 11(19): 5933.     CrossRef
  • Risk of Carotid Atherosclerosis in Subjects with Prediabetes Overlapping Metabolic Syndrome
    Seol A Jang, Kyoung Min Kim, Seok Won Park, Chul Sik Kim
    Metabolic Syndrome and Related Disorders.2022; 20(10): 599.     CrossRef
  • Lifestyle changes and risk of tuberculosis in patients with type 2 diabetes mellitus: A nationwide cohort study
    Jiho Park, Ji Hyun Yoon, Hyun Kyun Ki, Kyungdo Han, Hyungjin Kim
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Analysis of Clinical and Functional Outcomes according to the Blood Sugar Control Status at the Time of Ankle Fractures Resulting from Rotational Injuries
    Jun Young Lee, Dong Seop Lim, Seung Hyun Lee, Seo Jin Park
    Journal of the Korean Fracture Society.2022; 35(4): 135.     CrossRef
  • Differences in health behavior and nutrient intake status between diabetes-aware and unaware Korean adults based on the Korea national health and nutrition examination survey 2016–18 data: A cross-sectional study
    Anshul Sharma, Chen Lulu, Kee-Ho Song, Hae-Jeung Lee
    Frontiers in Public Health.2022;[Epub]     CrossRef
  • Musculoskeletal complications in patients with diabetes mellitus
    Jong Han Choi, Hae-Rim Kim, Kee-Ho Song
    The Korean Journal of Internal Medicine.2022; 37(6): 1099.     CrossRef
  • Blood Biochemical Characteristics, Dietary Intake, and Risk Factors Related to Poor HbA1c Control in Elderly Korean Diabetes Patients: Comparison between the 4th(2007-2009) and the 7th(2016-2018) Korea National Health and Nutrition Examination Surveys
    Sung-Won Oh, Sook-Bae Kim
    Korean Journal of Community Nutrition.2022; 27(5): 406.     CrossRef
  • Improving Machine Learning Diabetes Prediction Models for the Utmost Clinical Effectiveness
    Juyoung Shin, Joonyub Lee, Taehoon Ko, Kanghyuck Lee, Yera Choi, Hun-Sung Kim
    Journal of Personalized Medicine.2022; 12(11): 1899.     CrossRef
  • Brachial-ankle pulse wave velocity as a predictor of long-term cardiovascular events in 2174 subjects with type 2 diabetes mellitus: A retrospective cohort study
    Hack-Lyoung Kim, Won Kyeong Jeon, Hyun Sung Joh, Woo-Hyun Lim, Jae-Bin Seo, Sang-Hyun Kim, Joo-Hee Zo, Myung-A Kim
    Medicine.2022; 101(45): e31758.     CrossRef
  • Artificial Intelligence-based Prediction of Diabetes and Prediabetes Using Health Checkup Data in Korea
    Hyeonseop Yuk, Juhui Gim, Jung Kee Min, Jaesuk Yun, Tae-Young Heo
    Applied Artificial Intelligence.2022;[Epub]     CrossRef
  • Sex Differences in the Effects of CDKAL1 Variants on Glycemic Control in Diabetic Patients: Findings from the Korean Genome and Epidemiology Study
    Hye Ah Lee, Hyesook Park, Young Sun Hong
    Diabetes & Metabolism Journal.2022; 46(6): 879.     CrossRef
  • Screening for Prediabetes and Diabetes in Korean Nonpregnant Adults: A Position Statement of the Korean Diabetes Association, 2022
    Kyung Ae Lee, Dae Jung Kim, Kyungdo Han, Suk Chon, Min Kyong Moon
    Diabetes & Metabolism Journal.2022; 46(6): 819.     CrossRef
  • Classification of Type 2 Diabetes Incidence Risk and the Health Behavior of the 30–50-Year-Old Korean Adults: Latent Class Analysis
    Roma Seol, Jin-Ho Chun
    International Journal of Environmental Research and Public Health.2022; 19(24): 16600.     CrossRef
  • Association between Amount of Alcohol Consumption and Serum Fasting Glucose Level in Korean Male in their 40s and 50s: The Seventh Korea National Health and Nutrition Examination Survey 2016-2018
    Jihyun Kim
    Korean Journal of Family Practice.2022; 12(5): 320.     CrossRef
  • Associated Factors with Health-related Quality of Life among Older Adults with Diabetes in Korea
    Eun-Kyung Lee, Sun-Young Jung
    The Korean Journal of Rehabilitation Nursing.2022; 25(2): 61.     CrossRef
  • Chronic Disease Prediction Using the Common Data Model: Development Study
    Chanjung Lee, Brian Jo, Hyunki Woo, Yoori Im, Rae Woong Park, ChulHyoung Park
    JMIR AI.2022; 1(1): e41030.     CrossRef
  • Threshold Dose-Response Association between Smoking Pack-Years and the Risk of Gallbladder Cancer: A Nationwide Cohort Study
    Joo-Hyun Park, Jung Yong Hong, Kyungdo Han
    SSRN Electronic Journal .2022;[Epub]     CrossRef
  • The risk of stroke according to statin medication compliance in older people with chronic periodontitis: an analysis using the Korea National Health Insurance Service-Senior Cohort Database
    Seon-Rye Kim, Minkook Son, Yu-Rin Kim
    Epidemiology and Health.2022; 44: e2022055.     CrossRef
  • 2021 Clinical Practice Guidelines for Diabetes Mellitus of the Korean Diabetes Association
    Kyu Yeon Hur, Min Kyong Moon, Jong Suk Park, Soo-Kyung Kim, Seung-Hwan Lee, Jae-Seung Yun, Jong Ha Baek, Junghyun Noh, Byung-Wan Lee, Tae Jung Oh, Suk Chon, Ye Seul Yang, Jang Won Son, Jong Han Choi, Kee Ho Song, Nam Hoon Kim, Sang Yong Kim, Jin Wha Kim,
    Diabetes & Metabolism Journal.2021; 45(4): 461.     CrossRef
  • Treatment Patterns of Type 2 Diabetes Assessed Using a Common Data Model Based on Electronic Health Records of 2000–2019
    Kyung Ae Lee, Heung Yong Jin, Yu Ji Kim, Yong-Jin Im, Eun-Young Kim, Tae Sun Park
    Journal of Korean Medical Science.2021;[Epub]     CrossRef
  • Factors Associated with Depressive Symptoms in Korean Adults with Diabetes Mellitus: A Cross-Sectional Study
    Mihyun Jeong
    Healthcare.2021; 9(8): 1049.     CrossRef
  • Young-onset type 2 diabetes in South Korea: a review of the current status and unmet need
    Ye Seul Yang, Kyungdo Han, Tae Seo Sohn, Nam Hoon Kim
    The Korean Journal of Internal Medicine.2021; 36(5): 1049.     CrossRef
  • Metabolic Effects of Gastrectomy and Duodenal Bypass in Early Gastric Cancer Patients with T2DM: A Prospective Single-Center Cohort Study
    Young Ki Lee, Eun Kyung Lee, You Jin Lee, Bang Wool Eom, Hong Man Yoon, Young-Il Kim, Soo Jeong Cho, Jong Yeul Lee, Chan Gyoo Kim, Sun-Young Kong, Min Kyong Yoo, Yul Hwangbo, Young-Woo Kim, Il Ju Choi, Hak Jin Kim, Mi Hyang Kwak, Keun Won Ryu
    Journal of Clinical Medicine.2021; 10(17): 4008.     CrossRef
  • Sex- and Age-Specific Trends in Cardiovascular Health in Korea, 2007–2018
    So Mi Jemma Cho, Hokyou Lee, Hyeon Chang Kim
    Korean Circulation Journal.2021; 51(11): 922.     CrossRef
  • Efficacy and Safety of Switching to Teneligliptin in Patients with Type 2 Diabetes Inadequately Controlled with Dipeptidyl Peptidase-4 Inhibitors: 52-Week Results from a Prospective Observational Study
    Hae Jin Kim, Young Sik Kim, Chang Beom Lee, Moon-Gi Choi, Hyuk-Jae Chang, Soo Kyoung Kim, Jae Myung Yu, Tae Ho Kim, Ji Hyun Lee, Kyu Jeung Ahn, Kyung Wan Min, Eun Jung Kyung, Yeo Kyeong Kim, Kwan Woo Lee
    Diabetes Therapy.2021; 12(11): 2907.     CrossRef
  • RANTES 59029A/G Polymorphisms Associated with Diabetic Compilations in Korean Patients with Type 2 Diabetes for over 15 Years
    Dong-Hwa Lee, Eu-Jeong Ku, Tae-Keun Oh, Hyun-Jeong Jeon
    Genes.2021; 12(9): 1445.     CrossRef
  • Combination of Statin and Ezetimibe versus Statin Monotherapy on Cardiovascular Disease and Type 2 Diabetes Incidence among Adults with Impaired Fasting Glucose: a Propensity-Matched Nationwide Cohort Study
    You-Bin Lee, Bongsung Kim, Kyungdo Han, Jung A Kim, Eun Roh, So-hyeon Hong, Kyung Mook Choi, Sei Hyun Baik, Hye Jin Yoo
    Journal of Lipid and Atherosclerosis.2021; 10(3): 303.     CrossRef
  • A Century of Progress in Diabetes Care with Insulin: A History of Innovations and Foundation for the Future
    Seung-Hwan Lee, Kun-Ho Yoon
    Diabetes & Metabolism Journal.2021; 45(5): 629.     CrossRef
  • Proteinuria as a significant predictive factor for the progression of carotid artery atherosclerosis in non-albuminuric type 2 diabetes
    Young-eun Kim, Minyoung Lee, Yong-ho Lee, Eun Seok Kang, Bong-soo Cha, Byung-Wan Lee
    Diabetes Research and Clinical Practice.2021; 181: 109082.     CrossRef
  • Symptom Clusters and Quality of Life in Patients with Type 2 Diabetes Mellitus
    Su-Yeon Hong, Yang-Sook Yoo
    Korean Journal of Adult Nursing.2021; 33(5): 498.     CrossRef
  • The association between triglyceride-glucose index, cardio-cerebrovascular diseases, and death in Korean adults: A retrospective study based on the NHIS-HEALS cohort
    Joungyoun Kim, Sang-Jun Shin, Hee-Taik Kang, Claudio Passino
    PLOS ONE.2021; 16(11): e0259212.     CrossRef
  • Effect of Breastfeeding and Its Duration on Impaired Fasting Glucose and Diabetes in Perimenopausal and Postmenopausal Women: Korea National Health and Nutrition Examination Survey (KNHANES) 2010–2019
    Byung-Soo Kwan, In-Ae Cho, Ji-Eun Park
    Medicines.2021; 8(11): 71.     CrossRef
  • The Correlation between Carotid Intima-Media Thickness and Neutrophil to Lymphocyte Ratio in Prediabetes Patients
    Dayoung Lee, Mi-Jeong Park, Mee Young Kim, Jung Jin Cho, Jong Lull Yoon
    Korean Journal of Family Medicine.2021; 42(6): 464.     CrossRef
  • Muscle strength, an independent determinant of glycemic control in older adults with long-standing type 2 diabetes: a prospective cohort study
    Bo Kyung Koo, Seoil Moon, Min Kyong Moon
    BMC Geriatrics.2021;[Epub]     CrossRef
  • Restoration for the foregut surgery: bridging gaps between foregut surgery practice and academia
    Ye-lim Shin, Shin-Hoo Park, Yeongkeun Kwon, Chang Min Lee, Sungsoo Park
    Journal of Minimally Invasive Surgery.2021; 24(4): 175.     CrossRef
  • Prevalence and Treatment of Diabetes in China, 2013-2018
    Limin Wang, Wen Peng, Zhenping Zhao, Mei Zhang, Zumin Shi, Ziwei Song, Xiao Zhang, Chun Li, Zhengjing Huang, Xiaomin Sun, Linhong Wang, Maigeng Zhou, Jing Wu, Youfa Wang
    JAMA.2021; 326(24): 2498.     CrossRef
  • 2021 Clinical Practice Guidelines for Diabetes Mellitus in Korea
    Seung-Hyun Ko
    The Journal of Korean Diabetes.2021; 22(4): 244.     CrossRef
  • Spatiotemporal analyses of the epidemiological characteristics of diabetes mellitus
    Sang Youl Rhee
    Epidemiology and Health.2021; 43: e2021102.     CrossRef
  • Associations between grip strength and glycemic control in type 2 diabetes mellitus: an analysis of data from the 2014-2019 Korea National Health and Nutrition Examination Survey
    Harim Choe, Hoyong Sung, Geon Hui Kim, On Lee, Hyo Youl Moon, Yeon Soo Kim
    Epidemiology and Health.2021; 43: e2021080.     CrossRef
Response: Hypoglycemia and Dementia Risk in Older Patients with Type 2 Diabetes Mellitus: A Propensity-Score Matched Analysis of a Population-Based Cohort Study (Diabetes Metab J 2020;44:125–33)
Seung Jin Han
Diabetes Metab J. 2020;44(2):360-361.   Published online April 23, 2020
DOI: https://doi.org/10.4093/dmj.2020.0079
[Original]
  • 3,750 View
  • 63 Download
  • 2 Crossref
PDFPubReader   

Citations

Citations to this article as recorded by  
  • Prediction Models for Prognosis of Hypoglycemia in Patients with Diabetes: A Systematic Review and Meta-Analysis
    Yi Wu, Ruxue Li, Yating Zhang, Tianxue Long, Qi Zhang, Mingzi Li
    Biological Research For Nursing.2023; 25(1): 41.     CrossRef
  • The Effectiveness of Antidiabetic Drugs in Treating Dementia: A Peek into Pharmacological and Pharmacokinetic Properties
    Jiro Ogura, Hiroaki Yamaguchi
    International Journal of Molecular Sciences.2022; 23(12): 6542.     CrossRef
Clinical Complications
Hypoglycemia and Dementia Risk in Older Patients with Type 2 Diabetes Mellitus: A Propensity-Score Matched Analysis of a Population-Based Cohort Study
Young-Gun Kim, Dong Gyu Park, So Young Moon, Ja Young Jeon, Hae Jin Kim, Dae Jung Kim, Kwan-Woo Lee, Seung Jin Han
Diabetes Metab J. 2020;44(1):125-133.   Published online October 23, 2019
DOI: https://doi.org/10.4093/dmj.2018.0260
  • 7,731 View
  • 225 Download
  • 32 Web of Science
  • 32 Crossref
AbstractAbstract PDFPubReader   
Background

Type 2 diabetes mellitus (T2DM) is associated with an increased risk for dementia. The effects of hypoglycemia on dementia are controversial. Thus, we evaluated whether hypoglycemia increases the risk for dementia in senior patients with T2DM.

Methods

We used the Korean National Health Insurance Service Senior cohort, which includes >10% of the entire senior population of South Korea. In total, 5,966 patients who had ever experienced at least one episode of hypoglycemia were matched with those who had not, using propensity score matching. The risk of dementia was assessed through a survival analysis of matched pairs.

Results

Patients with underlying hypoglycemic events had an increased risk for all-cause dementia, Alzheimer's dementia (AD), and vascular dementia (VaD) compared with those who had not experienced a hypoglycemic event (hazard ratio [HR], 1.254; 95% confidence interval [CI], 1.166 to 1.349; P<0.001 for all-cause dementia; HR, 1.264; 95% CI, 1.162 to 1.375; P<0.001 for AD; HR, 1.286; 95% CI, 1.110 to 1.490; P<0.001 for VaD). According to number of hypoglycemic episodes, the HRs of dementia were 1.170, 1.201, and 1.358 in patients with one hypoglycemic episode, two or three episodes, and more than three episodes, respectively. In the subgroup analysis, hypoglycemia was associated with an increased risk for dementia in both sexes with or without T2DM microvascular or macrovascular complications.

Conclusion

Our findings suggest that patients with a history of hypoglycemia have a higher risk for dementia. This trend was similar for AD and VaD, the two most important subtypes of dementia.

Citations

Citations to this article as recorded by  
  • Potential risk factors for mild cognitive impairment among patients with type 2 diabetes experiencing hypoglycemia
    Ruonan Gao, Menglan Zhan, Sujie Ke, Kejun Wu, Guanlian He, Liqin Qi, Xiaoying Liu, Xiaohong Liu, Lijing Wang, Libin Liu
    Diabetes Research and Clinical Practice.2024; 207: 111036.     CrossRef
  • Association of hypoglycemic events with cognitive impairment in patients with type 2 diabetes mellitus: Protocol for a dose-response meta-analysis
    Min Ye, Ai Hong Yuan, Qi Qi Yang, Qun Wei Li, Fei Yue Li, Yan Wei, Muhammad Shahzad Aslam
    PLOS ONE.2024; 19(2): e0296662.     CrossRef
  • AGE, DISEASE DURATION AND MULTIMORBIDITY AS PREDICTORS OF HYPOGLYCEMIA IN ELDERLY AND SENILE WOMEN WITH TYPE 2 DIABETES MELLITUS
    Polina Ya. Merzlova, Svetlana V. Bulgakova, Dmitry P. Kurmaev, Ekaterina V. Treneva
    Science and Innovations in Medicine.2024;[Epub]     CrossRef
  • A nomogram for predicting the risk of cancer-related cognitive impairment in breast cancer patients based on a scientific symptom model
    Zhongtao Zhou, Jiajia Ren, Qiankun Liu, Shuoshuo Li, Jiahui Xu, Xiaoyan Wu, Yuanxiang Xiao, Zipu Zhang, Wanchen Jia, Huaiyu Bai, Jing Zhang
    Scientific Reports.2024;[Epub]     CrossRef
  • Взаимосвязь гипогликемии и когнитивных нарушений у пожилых пациентов с сахарным диабетом 2 типа
    S. V. Bulgakova, P. Ya. Merzlova, D. P. Kurmaev, E. V. Treneva
    Russian Journal of Geriatric Medicine.2024; (2): 108.     CrossRef
  • Effect of hypoglycemic events on cognitive function in individuals with type 2 diabetes mellitus: a dose–response meta-analysis
    Min Ye, Qiqi Yang, Lele Zhang, Hudie Song, Qin Fu, Jun Qian, Hongyu Xie, Aihong Yuan
    Frontiers in Neurology.2024;[Epub]     CrossRef
  • Hypoglycaemia and the risk of dementia: a population-based cohort study using exposure density sampling
    Wajd Alkabbani, Colleen J Maxwell, Ruth Ann Marrie, Suzanne L Tyas, Iliana C Lega, John-Michael Gamble
    International Journal of Epidemiology.2023; 52(3): 908.     CrossRef
  • Type 2 diabetes mellitus and cognitive function: understanding the connections
    Lisa Dao, Sarah Choi, Matthew Freeby
    Current Opinion in Endocrinology, Diabetes & Obesity.2023; 30(1): 7.     CrossRef
  • Associations of Mid- and Late-Life Severe Hypoglycemic Episodes With Incident Dementia Among Patients With Type 2 Diabetes: A Population-Based Cohort Study
    Wajd Alkabbani, Colleen J. Maxwell, Ruth Ann Marrie, Suzanne L. Tyas, Iliana C. Lega, John-Michael Gamble
    Diabetes Care.2023; 46(2): 331.     CrossRef
  • Nocturnal hypoglycemia is underdiagnosed in older people with insulin‐treated type 2 diabetes: The HYPOAGE observational study
    Anne‐Sophie Boureau, Béatrice Guyomarch, Pierre Gourdy, Ingrid Allix, Cédric Annweiler, Nathalie Cervantes, Guillaume Chapelet, Isabelle Delabrière, Sophie Guyonnet, Rachel Litke, Marc Paccalin, Alfred Penfornis, Pierre‐Jean Saulnier, Matthieu Wargny, Sam
    Journal of the American Geriatrics Society.2023; 71(7): 2107.     CrossRef
  • Dementia in Diabetes: The Role of Hypoglycemia
    Khaled Hameed Husain, Saud Faisal Sarhan, Haya Khaled Ali Abdulla AlKhalifa, Asal Buhasan, Abu Saleh Md Moin, Alexandra E. Butler
    International Journal of Molecular Sciences.2023; 24(12): 9846.     CrossRef
  • Association Between Trajectory of Severe Hypoglycemia and Dementia in Patients With Type 2 Diabetes: A Population-based Study
    Chung-Yi Li, Chia-Lun Kuo, Ya-Hui Chang, Chin-Li Lu, Santi Martini, Wen-Hsuan Hou
    Journal of Epidemiology.2022; 32(9): 423.     CrossRef
  • Severe Hypoglycemia Increases Dementia Risk and Related Mortality: A Nationwide, Population-based Cohort Study
    Eugene Han, Kyung-do Han, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Seung-Hyun Ko, Yong-ho Lee
    The Journal of Clinical Endocrinology & Metabolism.2022; 107(5): e1976.     CrossRef
  • Association between hypoglycemia and dementia in patients with diabetes: a systematic review and meta-analysis of 1.4 million patients
    Lifen Huang, Manlian Zhu, Jie Ji
    Diabetology & Metabolic Syndrome.2022;[Epub]     CrossRef
  • Potential Roles of Glucagon-Like Peptide-1 and Its Analogues in Dementia Targeting Impaired Insulin Secretion and Neurodegeneration
    Sidharth Mehan, Sonalika Bhalla, Ehraz Mehmood Siddiqui, Nidhi Sharma, Ambika Shandilya, Andleeb Khan
    Degenerative Neurological and Neuromuscular Disease.2022; Volume 12: 31.     CrossRef
  • Immortal time bias for life-long conditions in retrospective observational studies using electronic health records
    Freya Tyrer, Krishnan Bhaskaran, Mark J. Rutherford
    BMC Medical Research Methodology.2022;[Epub]     CrossRef
  • Glucose-lowering drugs, cognition, and dementia: The clinical evidence
    Che-Yuan Wu, Lila Shapiro, Michael Ouk, Bradley J. MacIntosh, Sandra E. Black, Baiju R. Shah, Walter Swardfager
    Neuroscience & Biobehavioral Reviews.2022; 137: 104654.     CrossRef
  • Switching insulin degludec to insulin glulisine improved nocturnal hypoglycemia and ventricular arrythmia in an elderly type 1 diabetes patient with chronic heart failure: A case report
    Yuriko Hajika, Yuji Kawaguchi, Takako Tanaka, Kenji Hamazaki, Yasuro Kumeda
    Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics.2022; 59(2): 237.     CrossRef
  • Diagnostic, Prognostic, and Mechanistic Biomarkers of Diabetes Mellitus-Associated Cognitive Decline
    Hanan Ehtewish, Abdelilah Arredouani, Omar El-Agnaf
    International Journal of Molecular Sciences.2022; 23(11): 6144.     CrossRef
  • Amyloid $$upbeta$$ (1–42) peptide impairs mitochondrial respiration in primary human brain microvascular endothelial cells: impact of dysglycemia and pre-senescence
    Siva S. V. P. Sakamuri, Venkata N. Sure, Xiaoying Wang, Gregory Bix, Vivian A. Fonseca, Ricardo Mostany, Prasad V. G. Katakam
    GeroScience.2022; 44(6): 2721.     CrossRef
  • Mechanistic Role of Jak3 in Obesity-Associated Cognitive Impairments
    Premranjan Kumar, Jayshree Mishra, Narendra Kumar
    Nutrients.2022; 14(18): 3715.     CrossRef
  • Assessing real-world effectiveness of therapies: what is the impact of incretin-based treatments on hospital use for patients with type 2 diabetes?
    Clémence Bussiere, Pauline Chauvin, Jean-Michel Josselin, Christine Sevilla-Dedieu
    Health Economics Review.2022;[Epub]     CrossRef
  • Fasting Glucose Variability and the Risk of Dementia in Individuals with Diabetes: A Nationwide Cohort Study
    Da Young Lee, Jaeyoung Kim, Sanghyun Park, So Young Park, Ji Hee Yu, Ji A Seo, Nam Hoon Kim, Hye Jin Yoo, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Kyungdo Han, Nan Hee Kim
    Diabetes & Metabolism Journal.2022; 46(6): 923.     CrossRef
  • Meta-Analysis: Association Between Hypoglycemia and Serious Adverse Events in Older Patients Treated With Glucose-Lowering Agents
    Katharina Mattishent, Yoon K. Loke
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Hypoglycemia, Vascular Disease and Cognitive Dysfunction in Diabetes: Insights from Text Mining-Based Reconstruction and Bioinformatics Analysis of the Gene Networks
    Olga V. Saik, Vadim V. Klimontov
    International Journal of Molecular Sciences.2021; 22(22): 12419.     CrossRef
  • Muscle strength, an independent determinant of glycemic control in older adults with long-standing type 2 diabetes: a prospective cohort study
    Bo Kyung Koo, Seoil Moon, Min Kyong Moon
    BMC Geriatrics.2021;[Epub]     CrossRef
  • Optimal Type 2 Diabetes Mellitus Management and Active Ageing
    Alessia Maria Calabrese, Valeria Calsolaro, Sara Rogani, Chukwuma Okoye, Nadia Caraccio, Fabio Monzani
    Endocrines.2021; 2(4): 523.     CrossRef
  • Response: Hypoglycemia and Dementia Risk in Older Patients with Type 2 Diabetes Mellitus: A Propensity-Score Matched Analysis of a Population-Based Cohort Study (Diabetes Metab J 2020;44:125–33)
    Seung Jin Han
    Diabetes & Metabolism Journal.2020; 44(2): 360.     CrossRef
  • Severe hypoglycaemia and absolute risk of cause-specific mortality in individuals with type 2 diabetes: a UK primary care observational study
    Francesco Zaccardi, Suping Ling, Claire Lawson, Melanie J. Davies, Kamlesh Khunti
    Diabetologia.2020; 63(10): 2129.     CrossRef
  • Letter: Hypoglycemia and Dementia Risk in Older Patients with Type 2 Diabetes Mellitus: A Propensity-Score Matched Analysis of a Population-Based Cohort Study (Diabetes Metab J 2020;44:125–33)
    Jin Hwa Kim
    Diabetes & Metabolism Journal.2020; 44(2): 356.     CrossRef
  • Low‐glucose‐sensitive TRPC6 dysfunction drives hypoglycemia‐induced cognitive impairment in diabetes
    Chengkang He, Peng Gao, Yuanting Cui, Qiang Li, Yingsha Li, Zongshi Lu, Huan Ma, Yu Zhao, Li Li, Fang Sun, Xiaowei Chen, Hongbo Jia, Daoyan Liu, Gangyi Yang, Hongting Zheng, Zhiming Zhu
    Clinical and Translational Medicine.2020;[Epub]     CrossRef
  • Hypoglycaemia and Cardiovascular Disease Risk in Patients with Diabetes
    Niki Katsiki, Kalliopi Kotsa, Anca P. Stoian, Dimitri P. Mikhailidis
    Current Pharmaceutical Design.2020; 26(43): 5637.     CrossRef
Response: Association of Thigh Muscle Mass with Insulin Resistance and Incident Type 2 Diabetes Mellitus in Japanese Americans (Diabetes Metab J 2018;42:488–95)
Seung Jin Han, Edward J. Boyko
Diabetes Metab J. 2019;43(1):125-126.   Published online February 19, 2019
DOI: https://doi.org/10.4093/dmj.2019.0028
  • 3,092 View
  • 37 Download
PDFPubReader   
Epidemiology
Association of Thigh Muscle Mass with Insulin Resistance and Incident Type 2 Diabetes Mellitus in Japanese Americans
Seung Jin Han, Edward J. Boyko, Soo-Kyung Kim, Wilfred Y. Fujimoto, Steven E. Kahn, Donna L. Leonetti
Diabetes Metab J. 2018;42(6):488-495.   Published online September 5, 2018
DOI: https://doi.org/10.4093/dmj.2018.0022
  • 5,381 View
  • 79 Download
  • 36 Web of Science
  • 36 Crossref
AbstractAbstract PDFPubReader   
Background

Skeletal muscle plays a major role in glucose metabolism. We investigated the association between thigh muscle mass, insulin resistance, and incident type 2 diabetes mellitus (T2DM) risk. In addition, we examined the role of body mass index (BMI) as a potential effect modifier in this association.

Methods

This prospective study included 399 Japanese Americans without diabetes (mean age 51.6 years) who at baseline had an estimation of thigh muscle mass by computed tomography and at baseline and after 10 years of follow-up a 75-g oral glucose tolerance test and determination of homeostasis model assessment of insulin resistance (HOMA-IR). We fit regression models to examine the association between thigh muscle area and incidence of T2DM and change in HOMA-IR, both measured over 10 years.

Results

Thigh muscle area was inversely associated with future HOMA-IR after adjustment for age, sex, BMI, HOMA-IR, fasting plasma glucose, total abdominal fat area, and thigh subcutaneous fat area at baseline (P=0.033). The 10-year cumulative incidence of T2DM was 22.1%. A statistically significant interaction between thigh muscle area and BMI was observed, i.e., greater thigh muscle area was associated with lower risk of incident T2DM for subjects at lower levels of BMI, but this association diminished at higher BMI levels.

Conclusion

Thigh muscle mass area was inversely associated with future insulin resistance. Greater thigh muscle area predicts a lower risk of incident T2DM for leaner Japanese Americans.

Citations

Citations to this article as recorded by  
  • Shape phenotype of thigh fat and muscle and risk of major adverse cardiovascular events after fragility hip fracture
    Sheen‐Woo Lee, Seung‐Chan Kim, Jeong‐Eun Yi
    Journal of Cachexia, Sarcopenia and Muscle.2024; 15(1): 331.     CrossRef
  • CD36 gene variant rs1761667(G/A) as a biomarker in obese type 2 diabetes mellitus cases
    Ashwin Kumar Shukla, Amreen Shamsad, Atar Singh Kushwah, Shalini Singh, Kauser Usman, Monisha Banerjee
    Egyptian Journal of Medical Human Genetics.2024;[Epub]     CrossRef
  • Association between macro- and microvascular damage and sarcopenia index in individuals with type 2 diabetes mellitus
    Hui Xu, Qun-Yan Xiang, Jun-Kun Zhan, Yi Wang, Yan-Jiao Wang, Shuang Li, You-Shuo Liu
    Applied Physiology, Nutrition, and Metabolism.2024; 49(6): 762.     CrossRef
  • MicroRNA‐29‐mediated cross‐talk between metabolic organs in the pathogenesis of diabetes mellitus and its complications: A narrative review
    Hassen Ahmed Yesuf, Meseret Derbew Molla, Tabarak Malik, Zeru Seyoum Wendimagegn, Yadelew Yimer
    Cell Biochemistry and Function.2024;[Epub]     CrossRef
  • Causality between sarcopenia and diabetic neuropathy
    Yi Fang, Xiaoqing Yuan, Qing Zhang, Juan Liu, Qing Yao, Xinhua Ye
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • More appendicular lean mass relative to body mass index is associated with lower incident diabetes in middle-aged adults in the CARDIA study
    Melanie S. Haines, Aaron Leong, Bianca C. Porneala, Victor W. Zhong, Cora E. Lewis, Pamela J. Schreiner, Karen K. Miller, James B. Meigs, Mercedes R. Carnethon
    Nutrition, Metabolism and Cardiovascular Diseases.2023; 33(1): 105.     CrossRef
  • Involvement of the fecal amino acid profile in a clinical and anthropometric study of Mexican patients with insulin resistance and type 2 diabetes mellitus
    Mayra Paloma Macías-Acosta, Lorena Valerdi-Contreras, Ericka Denise Bustos-Angel, Rudy Antonio García-Reyes, Monserrat Alvarez-Zavala, Marisela González-Ávila
    Amino Acids.2022; 54(1): 47.     CrossRef
  • Association of serum creatinine levels and risk of type 2 diabetes mellitus in Korea: a case control study
    Do Kyeong Song, Young Sun Hong, Yeon-Ah Sung, Hyejin Lee
    BMC Endocrine Disorders.2022;[Epub]     CrossRef
  • The Relationship Between Fat-Free Mass and Glucose Metabolism in Children and Adolescents: A Systematic Review and Meta-Analysis
    Lijun Wu, Fangfang Chen, Junting Liu, Dongqing Hou, Tao Li, Yiren Chen, Zijun Liao
    Frontiers in Pediatrics.2022;[Epub]     CrossRef
  • Is imaging-based muscle quantity associated with risk of diabetes? A meta-analysis of cohort studies
    Shanhu Qiu, Xue Cai, Yang Yuan, Bo Xie, Zilin Sun, Tongzhi Wu
    Diabetes Research and Clinical Practice.2022; 189: 109939.     CrossRef
  • Effects of Exercise Intervention on Type 2 Diabetes Patients With Abdominal Obesity and Low Thigh Circumference (EXTEND): Study Protocol for a Randomized Controlled Trial
    Dan Liu, Ying Zhang, Liang Wu, Jingyi Guo, Xiangtian Yu, Huasheng Yao, Rui Han, Tianshu Ma, Yuchan Zheng, Qiongmei Gao, Qichen Fang, Yan Zhao, Yanan Zhao, Biao Sun, Weiping Jia, Huating Li
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Association between diabetic peripheral neuropathy and sarcopenia: A systematic review and meta‐analysis
    Thapat Wannarong, Persen Sukpornchairak, Weerakit Naweera, Christopher D. Geiger, Patompong Ungprasert
    Geriatrics & Gerontology International.2022; 22(9): 785.     CrossRef
  • Synergistic Interaction between Hyperuricemia and Abdominal Obesity as a Risk Factor for Metabolic Syndrome Components in Korean Population
    Min Jin Lee, Ah Reum Khang, Yang Ho Kang, Mi Sook Yun, Dongwon Yi
    Diabetes & Metabolism Journal.2022; 46(5): 756.     CrossRef
  • HOMA-IR as a predictor of Health Outcomes in Patients with Metabolic Risk Factors: A Systematic Review and Meta-analysis
    José G. González-González, Jorge R. Violante-Cumpa, Miguel Zambrano-Lucio, Erick Burciaga-Jimenez, Patricia L. Castillo-Morales, Mariano Garcia-Campa, Ricardo César Solis, Alejandro D González-Colmenero, René Rodríguez-Gutiérrez
    High Blood Pressure & Cardiovascular Prevention.2022; 29(6): 547.     CrossRef
  • Maternal height as a predictor of glucose intolerance in the postpartum and its relationship with maternal pre-gestational weight
    Catarina Cidade-Rodrigues, Filipe M. Cunha, Catarina Chaves, Fabiana Castro, Catarina Pereira, Sílvia Paredes, Margarida Silva-Vieira, Anabela Melo, Odete Figueiredo, Cláudia Nogueira, Ana Morgado, Mariana Martinho, Maria C. Almeida, Margarida Almeida
    Archives of Gynecology and Obstetrics.2022; 307(2): 601.     CrossRef
  • Correlation of body composition in early pregnancy on gestational diabetes mellitus under different body weights before pregnancy
    Li Xintong, Xu Dongmei, Zhang Li, Cao Ruimin, Hao Yide, Cui Lingling, Chen Tingting, Guo Yingying, Li Jiaxin
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Relationship between low skeletal muscle mass, sarcopenic obesity and left ventricular diastolic dysfunction in Korean adults
    Jee Hee Yoo, Sung Woon Park, Ji Eun Jun, Sang‐Man Jin, Kyu Yeon Hur, Moon‐Kyu Lee, Mira Kang, Gyuri Kim, Jae Hyeon Kim
    Diabetes/Metabolism Research and Reviews.2021;[Epub]     CrossRef
  • Skeletal Muscle and Metabolic Health: How Do We Increase Muscle Mass and Function in People with Type 2 Diabetes?
    Ebaa Al-Ozairi, Dalal Alsaeed, Dherar Alroudhan, Nia Voase, Amal Hasan, Jason M R Gill, Naveed Sattar, Paul Welsh, Cindy M Gray, Jirapitcha Boonpor, Carlos Celis-Morales, Stuart R Gray
    The Journal of Clinical Endocrinology & Metabolism.2021; 106(2): 309.     CrossRef
  • Association of the triglyceride and glucose index with low muscle mass: KNHANES 2008–2011
    Jung A. Kim, Soon Young Hwang, Ji Hee Yu, Eun Roh, So-hyeon Hong, You-Bin Lee, Nam Hoon Kim, Hye Jin Yoo, Ji A. Seo, Nan Hee Kim, Sin Gon Kim, Sei Hyun Baik, Kyung Mook Choi
    Scientific Reports.2021;[Epub]     CrossRef
  • ADAS-viewer: web-based application for integrative analysis of multi-omics data in Alzheimer’s disease
    Seonggyun Han, Jaehang Shin, Hyeim Jung, Jane Ryu, Habtamu Minassie, Kwangsik Nho, Insong Koh, Younghee Lee
    npj Systems Biology and Applications.2021;[Epub]     CrossRef
  • Relative associations of abdominal and thigh compositions with cardiometabolic diseases in African Caribbean men
    Curtis Tilves, Joseph M. Zmuda, Allison L. Kuipers, Sangeeta Nair, John Jeffrey Carr, James G. Terry, Shyamal Peddada, Victor Wheeler, Iva Miljkovic
    Obesity Science & Practice.2021; 7(6): 738.     CrossRef
  • Changes in creatinine‐to‐cystatin C ratio over 4 years, risk of diabetes, and cardiometabolic control: The China Health and Retirement Longitudinal Study
    Shanhu Qiu, Xue Cai, Yang Yuan, Bo Xie, Zilin Sun, Tongzhi Wu
    Journal of Diabetes.2021; 13(12): 1025.     CrossRef
  • Associations Between Glucose Tolerance, Insulin Secretion, Muscle and Fat Mass in Cystic Fibrosis
    Bibi Uhre Nielsen, Daniel Faurholt-Jepsen, Peter Sandor Oturai, Tavs Qvist, Rikke Krogh-Madsen, Terese Lea Katzenstein, James Shaw, Christian Ritz, Tacjana Pressler, Thomas Peter Almdal, Inger Hee Mabuza Mathiesen
    Clinical Medicine Insights: Endocrinology and Diabetes.2021;[Epub]     CrossRef
  • Total and regional fat‐to‐muscle mass ratio measured by bioelectrical impedance and risk of incident type 2 diabetes
    Ningjian Wang, Ying Sun, Haojie Zhang, Chi Chen, Yuying Wang, Jihui Zhang, Fangzhen Xia, Christian Benedict, Xiao Tan, Yingli Lu
    Journal of Cachexia, Sarcopenia and Muscle.2021; 12(6): 2154.     CrossRef
  • How was the Diabetes Metabolism Journal added to MEDLINE?
    Hye Jin Yoo
    Science Editing.2020; 7(2): 201.     CrossRef
  • An update on nutrient modulation in the management of disease-induced muscle wasting: evidence from human studies
    Matthew S. Brook, Daniel J. Wilkinson, Philip J. Atherton
    Current Opinion in Clinical Nutrition & Metabolic Care.2020; 23(3): 174.     CrossRef
  • The functional nutritional and regulatory activities of calcium supplementation from eggshell for obesity disorders management
    Marwa El‐Zeftawy, Samar Abd‐El Mohsen Ali, Sally Salah, Hani S. Hafez
    Journal of Food Biochemistry.2020;[Epub]     CrossRef
  • Dose‐response associations between serum creatinine and type 2 diabetes mellitus risk: A Chinese cohort study and meta‐analysis of cohort studies
    Pei Qin, Yanmei Lou, Liming Cao, Jing Shi, Gang Tian, Dechen Liu, Qionggui Zhou, Chunmei Guo, Quanman Li, Yang Zhao, Feiyan Liu, Xiaoyan Wu, Ranran Qie, Minghui Han, Shengbing Huang, Ping Zhao, Changyi Wang, Jianping Ma, Xiaolin Peng, Shan Xu, Hongen Chen
    Journal of Diabetes.2020; 12(8): 594.     CrossRef
  • Caloric restriction in heart failure: A systematic review
    Vittorio Emanuele Bianchi
    Clinical Nutrition ESPEN.2020; 38: 50.     CrossRef
  • Association between the Thigh Muscle and Insulin Resistance According to Body Mass Index in Middle-Aged Korean Adults
    Ji Eun Heo, Jee-Seon Shim, Hokyou Lee, Hyeon Chang Kim
    Diabetes & Metabolism Journal.2020; 44(3): 446.     CrossRef
  • Joint impact of muscle mass and waist circumference on type 2 diabetes in Japanese middle‐aged adults: The Circulatory Risk in Communities Study (CIRCS)
    Mikako Yasuoka, Isao Muraki, Hironori Imano, Hiroshige Jinnouchi, Yasuhiko Kubota, Mina Hayama‐Terada, Mitsumasa Umesawa, Kazumasa Yamagishi, Tetsuya Ohira, Akihiko Kitamura, Takeo Okada, Masahiko Kiyama, Hiroyasu Iso
    Journal of Diabetes.2020; 12(9): 677.     CrossRef
  • Catch-Up Growth in Children Born Small for Gestational Age Related to Body Composition and Metabolic Risk at Six Years of Age in the UK
    M. Loredana Marcovecchio, Samantha Gorman, Laura P.E. Watson, David B. Dunger, Kathryn Beardsall
    Hormone Research in Paediatrics.2020; 93(2): 119.     CrossRef
  • Response: Association of Thigh Muscle Mass with Insulin Resistance and Incident Type 2 Diabetes Mellitus in Japanese Americans (Diabetes Metab J 2018;42:488–95)
    Seung Jin Han, Edward J. Boyko
    Diabetes & Metabolism Journal.2019; 43(1): 125.     CrossRef
  • Berberine chloride ameliorated PI3K/Akt‐p/SIRT‐1/PTEN signaling pathway in insulin resistance syndrome induced in rats
    Marwa El‐Zeftawy, Doaa Ghareeb, Eman R. ElBealy, Rasha Saad, Salma Mahmoud, Nihal Elguindy, Attalla F. El‐kott, Mohamed El‐Sayed
    Journal of Food Biochemistry.2019;[Epub]     CrossRef
  • Letter: Association of Thigh Muscle Mass with Insulin Resistance and Incident Type 2 Diabetes Mellitus in Japanese Americans (Diabetes Metab J 2018;42:488–95)
    Nan Hee Cho, Hye Soon Kim
    Diabetes & Metabolism Journal.2019; 43(1): 123.     CrossRef
  • Asian Indians With Prediabetes Have Similar Skeletal Muscle Mass and Function to Those With Type 2 Diabetes
    Sucharita Sambashivaiah, Stephen D. R. Harridge, Nidhi Sharma, Sumithra Selvam, Priyanka Rohatgi, Anura V. Kurpad
    Frontiers in Nutrition.2019;[Epub]     CrossRef
Epidemiology
The Evidence for an Obesity Paradox in Type 2 Diabetes Mellitus
Seung Jin Han, Edward J. Boyko
Diabetes Metab J. 2018;42(3):179-187.   Published online May 31, 2018
DOI: https://doi.org/10.4093/dmj.2018.0055
  • 8,432 View
  • 155 Download
  • 66 Web of Science
  • 68 Crossref
AbstractAbstract PDFPubReader   

Although overweight/obesity is a major risk factor for the development of type 2 diabetes mellitus, there is increasing evidence that overweight or obese patients with type 2 diabetes mellitus experience lower mortality compared with patients of normal weight. This paradoxical finding, known as the “obesity paradox,” occurs in other chronic diseases, and in type 2 diabetes mellitus is particularly perplexing given that lifestyle intervention with one goal being weight reduction is an important feature of the management of this condition. We summarize in this review the findings from clinical and epidemiologic studies that have investigated the association between overweight and obesity (usually assessed using body mass index [BMI]) and mortality in type 2 diabetes mellitus and discuss potential causes of the obesity paradox. We conclude that most studies show evidence of an obesity paradox, but important conflicting findings still exist. We also evaluate if potential bias might explain the obesity paradox in diabetes, including, for example, the presence of confounding factors, measurement error due to use of BMI as an index of obesity, and reverse causation.

Citations

Citations to this article as recorded by  
  • Influence of diabetes and obesity on ten-year outcomes after coronary artery bypass grafting in the arterial revascularisation trial
    Maria Stefil, Mario Gaudino, Umberto Benedetto, Stephen Gerry, Alastair Gray, Belinda Lees, Bruno Podesser, Lukasz Krzych, Lokeswara Rao Sajja, David Taggart, Marcus Flather
    Clinical Research in Cardiology.2024; 113(11): 1515.     CrossRef
  • Association between the weight-adjusted waist index and the odds of type 2 diabetes mellitus in United States adults: a cross-sectional study
    Dongdong Zheng, Suzhen Zhao, Dan Luo, Feng Lu, Zhishen Ruan, Xiaokang Dong, Wenjing Chen
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • Racial and Ethnic Disparities in Primary Prevention of Cardiovascular Disease
    Mohammad R. Ali, Hadjer Nacer, Claire A. Lawson, Kamlesh Khunti
    Canadian Journal of Cardiology.2024; 40(6): 1016.     CrossRef
  • Mortality outcomes in diabetic metabolic dysfunction-associated fatty liver disease: non-obese versus obese individuals
    Pengwei Zhang, Yijun Zeng, Sijia Yang, Chunhong Ye, Mingwei Wang, Tianfang Peng, Li Li, Xianhui Dong
    Scientific Reports.2024;[Epub]     CrossRef
  • Independent and interactive associations of heart rate and obesity with type 2 diabetes mellites: A population‐based study
    Tianxin Zhu, Qingyu Chen, Hongxing Chen, Lili You, Dan Liu, Xiaoyun Zhang, Feng Li, Hongshi Wu, Juying Tang, Diaozhu Lin, Kan Sun, Li Yan, Meng Ren
    Journal of Diabetes.2024;[Epub]     CrossRef
  • Investigating the causal association of generalized and abdominal obesity with microvascular complications in patients with type 2 diabetes: A community‐based prospective study
    Jiaheng Chen, Yu Ting Li, Zimin Niu, Zhanpeng He, Yao Jie Xie, Jose Hernandez, Wenyong Huang, Harry H X Wang
    Diabetes, Obesity and Metabolism.2024; 26(7): 2796.     CrossRef
  • Causal relationships of lifestyle behaviours and body fat distribution on diabetic microvascular complications: a Mendelian randomization study
    Nuojin Guo, Hekai Shi, Hongmei Zhao, Yierfan Abuduani, Da Chen, Xishuang Chen, Hua Wang, Peicheng Li
    Frontiers in Genetics.2024;[Epub]     CrossRef
  • Effect of body mass index on mortality for diabetic patients with aortic stenosis
    Kai-Chun Chang, Li-Ting Ho, Kuan-Chih Huang, Jung-Chi Hsu, David Te-Wei Kuan, Ting-Tse Lin, Jen-Kuang Lee, Yen-Yun Yang, Shu-Lin Chuang, Lian-Yu Lin
    Aging.2024; 16(14): 11359.     CrossRef
  • Clinical impact of visceral adiposity on long-term mortality in patients undergoing coronary artery bypass grafting
    Jinhwan Jo, Seung Hun Lee, Jeong Hoon Yang, Sung Mok Kim, Ki Hong Choi, Young Bin Song, Dong Seop Jeong, Joo Myung Lee, Taek Kyu Park, Joo-Yong Hahn, Seung-Hyuk Choi, Su Ryeun Chung, Yang Hyun Cho, Kiick Sung, Wook Sung Kim, Hyeon-Cheol Gwon, Young Tak Le
    Revista Española de Cardiología (English Edition).2024;[Epub]     CrossRef
  • Exploring lipodystrophy gene expression in adipocytes: unveiling insights into the pathogenesis of insulin resistance, type 2 diabetes, and clustering diseases (metabolic syndrome) in Asian Indians
    Aditya Saxena, Pradeep Tiwari, Shalu Gupta, Rajendra Mandia, Ramesh C. Banshiwal, Ravinder Kumar Lamoria, Ranjit Mohan Anjana, Venkatesan Radha, Viswanathan Mohan, Sandeep Kumar Mathur
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • The effect of weight reduction on the diabetes foot: A scoping review and clinical implications
    Janine Elizabeth Roll Ahmed, John Veto, Derek Santos
    Obesity Pillars.2024; : 100152.     CrossRef
  • Two‐sided roles of adipose tissue: Rethinking the obesity paradox in various human diseases from a new perspective
    Jing Pan, Jianqiong Yin, Lu Gan, Jianxin Xue
    Obesity Reviews.2023;[Epub]     CrossRef
  • Lean or diabetic subtypes predict increased all-cause and disease-specific mortality in metabolic-associated fatty liver disease
    Goh Eun Chung, Su Jong Yu, Jeong-Ju Yoo, Yuri Cho, Kyu-na Lee, Dong Wook Shin, Donghee Kim, Yoon Jun Kim, Jung-Hwan Yoon, Kyungdo Han, Eun Ju Cho
    BMC Medicine.2023;[Epub]     CrossRef
  • Dynamic changes in prevalence of type 2 diabetes along with associated factors in Bangladesh: Evidence from two national cross-sectional surveys (BDHS 2011 and BDHS 2017–18)
    Sabiha Shirin Sara, Ashis Talukder, Ka Yiu Lee, Nayan Basak, Shaharior Rahman Razu, Iqramul Haq, Chuton Deb Nath
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2023; 17(2): 102706.     CrossRef
  • Association of dietary intake with body mass index and glycemic profile among newly diagnosed patients with type 2 diabetes mellitus
    Keddagoda Gamage Piyumi Wasana, Anoja Priyadarshani Attanayake, Thilak Priyantha Weerarathna, Devpura Arachchige Bandumalee Nimalshanthi Amarasekera, Kamani Ayoma Perera Wijewardana Jayatilaka
    American Journal of Human Biology.2023;[Epub]     CrossRef
  • Can lipophilic pollutants in adipose tissue explain weight change‐related risk in type 2 diabetes mellitus?
    Duk‐Hee Lee, In‐Kyu Lee
    Journal of Diabetes Investigation.2023; 14(4): 528.     CrossRef
  • Visceral fat and attribute-based medicine in chronic kidney disease
    Hiroshi Kataoka, Kosaku Nitta, Junichi Hoshino
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • A primary care delivered, technology supported lifestyle program for Type 2 Diabetes Management: An evaluation of changes in metabolic health, feasibility, and acceptability – A pilot interventional study protocol
    Pennie J. Taylor, Campbell H. Thompson, Thomas P. Wycherley, Grant D. Brinkworth
    Contemporary Clinical Trials Communications.2023; 33: 101152.     CrossRef
  • The medical model of “obesity” and the values behind the guise of health
    Kayla R. Mehl
    Synthese.2023;[Epub]     CrossRef
  • Elevated MMP-8 levels, inversely associated with BMI, predict mortality in mechanically ventilated patients: an observational multicenter study
    Hang Ruan, Shu-sheng Li, Qin Zhang, Xiao Ran
    Critical Care.2023;[Epub]     CrossRef
  • Obesity and 30-day case fatality after hyperglycemic crisis hospitalizations in Korea: a national cohort study
    Hojun Yoon, Hyun Ho Choi, Giwoong Choi, Sun Ok Song, Kyoung Hwa Ha, Dae Jung Kim
    Cardiovascular Prevention and Pharmacotherapy.2023; 5(3): 74.     CrossRef
  • Normal‐weight central obesity and risk of cardiovascular and microvascular events in adults with prediabetes or diabetes: Chinese and British cohorts
    Pingting Zhong, Shaoying Tan, Zhuoting Zhu, Ziyu Zhu, Yi Liang, Wenyong Huang, Wei Wang
    Diabetes/Metabolism Research and Reviews.2023;[Epub]     CrossRef
  • Overweight and obesity are associated with better survival inSTEMIpatients with diabetes
    Hamza Chaudhry, Ramez Bodair, Ziyad Mahfoud, Soha Dargham, Jassim Al Suwaidi, Hani Jneid, Charbel Abi Khalil
    Obesity.2023; 31(11): 2834.     CrossRef
  • Poor glycaemic control: prevalence, factors and implications for the care of patients with type 2 diabetes in Kinshasa, Democratic Republic of the Congo: a cross-sectional study
    Jean-Pierre Fina Lubaki, Olufemi Babatunde Omole, Joel Msafiri Francis
    Frontiers in Clinical Diabetes and Healthcare.2023;[Epub]     CrossRef
  • Comparison of obesity indices and triglyceride glucose-related parameters to predict type 2 diabetes mellitus among normal-weight elderly in China
    Pan Ke, Xia Wu, Minzhi Xu, Jie Feng, Hongbin Xu, Yong Gan, Chao Wang, Zhenyu Deng, Xiang Liu, Wenning Fu, Qingfeng Tian, Yan He, Lirong Zhong, Heng Jiang, Zuxun Lu
    Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity.2022; 27(3): 1181.     CrossRef
  • Association Between Obesity and Cardiovascular Disease in Elderly Patients With Diabetes: A Retrospective Cohort Study
    Sangmo Hong, Jung Hwan Park, Kyungdo Han, Chang Beom Lee, Dong Sun Kim, Sung Hoon Yu
    The Journal of Clinical Endocrinology & Metabolism.2022; 107(2): e515.     CrossRef
  • The Relationship between the Lipid Accumulation Product and Beta-cell Function in Korean Adults with or without Type 2 Diabetes Mellitus: The 2015 Korea National Health and Nutrition Examination Survey
    Hye Eun Cho, Seung Bum Yang, Mi Young Gi, Ju Ae Cha, so Young Park, Hyun Yoon
    Endocrine Research.2022; 47(2): 80.     CrossRef
  • Body mass index and all-cause mortality in patients with newly diagnosed type 2 diabetes mellitus in South Korea: a retrospective cohort study
    Jae-Seok Hong, Hee-Chung Kang
    BMJ Open.2022; 12(4): e048784.     CrossRef
  • Social determinants of obesity in American Indian and Alaska Native peoples aged ≥ 50 years
    R Turner Goins, Cheryl Conway, Margaret Reid, Luohua Jiang, Jenny Chang, Kimberly R Huyser, Angela G Brega, John F Steiner, Amber L Fyfe-Johnson, Michelle Johnson-Jennings, Vanessa Hiratsuka, Spero M Manson, Joan O’Connell
    Public Health Nutrition.2022; 25(8): 2064.     CrossRef
  • Cardiorespiratory Fitness, BMI, Mortality, and Cardiovascular Disease in Adults with Overweight/Obesity and Type 2 Diabetes
    ANDREW C. WILLS, ELSA VAZQUEZ ARREOLA, MUIDEEN T. OLAIYA, JEFFREY M. CURTIS, MARGARETA I. HELLGREN, ROBERT L. HANSON, WILLIAM C. KNOWLER
    Medicine & Science in Sports & Exercise.2022; 54(6): 994.     CrossRef
  • Spline Longitudinal Multi-response Model for the Detection of Lifestyle- Based Changes in Blood Glucose of Diabetic Patients
    Anna Islamiyati
    Current Diabetes Reviews.2022;[Epub]     CrossRef
  • The obesity paradox: Retinopathy, obesity, and circulating risk markers in youth with type 2 diabetes in the TODAY Study
    Lynne L. Levitsky, Kimberly L. Drews, Morey Haymond, Rose A. Glubitosi-Klug, Lorraine E. Levitt Katz, Mihai Mititelu, William Tamborlane, Jeanie B. Tryggestad, Ruth S. Weinstock
    Journal of Diabetes and its Complications.2022; 36(11): 108259.     CrossRef
  • Distribution of lean mass and mortality risk in patients with type 2 diabetes
    Li Ding, Yuxin Fan, Jingting Qiao, Jing He, Ruodan Wang, Qing He, Jingqiu Cui, Zhongshu Ma, Fangqiu Zheng, Hua Gao, Chenlin Dai, Hongyan Wei, Jun Li, Yuming Cao, Gang Hu, Ming Liu
    Primary Care Diabetes.2022; 16(6): 824.     CrossRef
  • Current Knowledge on the Pathophysiology of Lean/Normal-Weight Type 2 Diabetes
    Teresa Salvatore, Raffaele Galiero, Alfredo Caturano, Luca Rinaldi, Livio Criscuolo, Anna Di Martino, Gaetana Albanese, Erica Vetrano, Christian Catalini, Celestino Sardu, Giovanni Docimo, Raffaele Marfella, Ferdinando Carlo Sasso
    International Journal of Molecular Sciences.2022; 24(1): 658.     CrossRef
  • The obesity paradox and diabetes
    Giovanni Gravina, Federica Ferrari, Grazia Nebbiai
    Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity.2021; 26(4): 1057.     CrossRef
  • Implicating the effect of ketogenic diet as a preventive measure to obesity and diabetes mellitus
    Sachin Kumar, Tapan Behl, Monika Sachdeva, Aayush Sehgal, Shilpa Kumari, Arun Kumar, Gagandeep Kaur, Harlokesh Narayan Yadav, Simona Bungau
    Life Sciences.2021; 264: 118661.     CrossRef
  • Diagnosis of obesity based on body composition‐associated health risks—Time for a change in paradigm
    Anja Bosy‐Westphal, Manfred J. Müller
    Obesity Reviews.2021;[Epub]     CrossRef
  • Body mass index and clinical outcomes in patients with intracerebral haemorrhage: results from the China Stroke Center Alliance
    Zhentang Cao, Xinmin Liu, Zixiao Li, Hongqiu Gu, Yingyu Jiang, Xingquan Zhao, Yongjun Wang
    Stroke and Vascular Neurology.2021; 6(3): 424.     CrossRef
  • Obesity and Overweight Are Associated with Minimal Extrathyroidal Extension, Multifocality and Bilaterality of Papillary Thyroid Cancer
    Krzysztof Kaliszewski, Dorota Diakowska, Marta Rzeszutko, Jerzy Rudnicki
    Journal of Clinical Medicine.2021; 10(5): 970.     CrossRef
  • Obesity paradox in patients with cardiovascular diseases and diabetes mellitus type 2 (analytical review)
    Margarita P. Zaikina, Valentina A. Kapustina, Stanislav I. Savel'ev
    HEALTH CARE OF THE RUSSIAN FEDERATION.2021; 65(2): 135.     CrossRef
  • Risk factors for adverse outcomes among 35 879 veterans with and without diabetes after diagnosis with COVID-19
    Pandora L Wander, Elliott Lowy, Lauren A Beste, Luis Tulloch-Palomino, Anna Korpak, Alexander C Peterson, Bessie A Young, Edward J Boyko
    BMJ Open Diabetes Research & Care.2021; 9(1): e002252.     CrossRef
  • Obesity and glycemic control among people with type 2 diabetes in the United States: A retrospective cohort study using insurance claims data
    Kristina S. Boye, Maureen J. Lage, Vivian Thieu, Shraddha Shinde, Shivanie Dhamija, Jay Patrick Bae
    Journal of Diabetes and its Complications.2021; 35(9): 107975.     CrossRef
  • Differential effects of body mass index on domain-specific cognitive outcomes after stroke
    Minwoo Lee, Mi Sun Oh, San Jung, Ju-Hun Lee, Chul-Ho Kim, Min Uk Jang, Young Eun Kim, Hee-Joon Bae, Jaeseol Park, Yeonwook Kang, Byung-Chul Lee, Jae-Sung Lim, Kyung-Ho Yu
    Scientific Reports.2021;[Epub]     CrossRef
  • Associations between traditional and non-traditional anthropometric indices and cardiometabolic risk factors among inpatients with type 2 diabetes mellitus: a cross-sectional study
    Sahar Golabi, Sajad Ajloo, Fatemeh Maghsoudi, Maryam Adelipour, Mahshid Naghashpour
    Journal of International Medical Research.2021;[Epub]     CrossRef
  • Impact of preexisting type 2 diabetes mellitus and antidiabetic drugs on all-cause and cause-specific mortality among Medicaid-insured women diagnosed with breast cancer
    Wayne R. Lawrence, Akiko S. Hosler, Margaret Gates Kuliszewski, Matthew C. Leinung, Xiuling Zhang, Maria J. Schymura, Francis P. Boscoe
    Cancer Epidemiology.2020; 66: 101710.     CrossRef
  • Serum Adiponectin and Progranulin Level in Patients with Benign Thyroid Nodule or Papillary Thyroid Cancer
    Hyemi Kwon, Se Eun Park, Ji-Sup Yun, Cheol-Young Park
    Endocrinology and Metabolism.2020; 35(2): 396.     CrossRef
  • Obesity, sleep apnea, and cancer
    Isaac Almendros, Miguel A. Martinez-Garcia, Ramon Farré, David Gozal
    International Journal of Obesity.2020; 44(8): 1653.     CrossRef
  • Association of Body Mass Index With Clinical Outcomes in Patients With Atrial Fibrillation: A Report From the FANTASIIA Registry
    Vicente Bertomeu‐Gonzalez, José Moreno‐Arribas, María Asunción Esteve‐Pastor, Inmaculada Roldán‐Rabadán, Javier Muñiz, Paula Raña‐Míguez, Martín Ruiz‐Ortiz, Ángel Cequier, Vicente Bertomeu‐Martínez, Lina Badimón, Manuel Anguita, Gregory Y. H. Lip, Francis
    Journal of the American Heart Association.2020;[Epub]     CrossRef
  • Risk of type 2 diabetes according to the cumulative exposure to metabolic syndrome or obesity: A nationwide population‐based study
    You‐Bin Lee, Da Hye Kim, Seon Mee Kim, Nan Hee Kim, Kyung Mook Choi, Sei Hyun Baik, Yong Gyu Park, Kyungdo Han, Hye Jin Yoo
    Journal of Diabetes Investigation.2020; 11(6): 1583.     CrossRef
  • Gut microbiota of obese and diabetic Thai subjects and interplay with dietary habits and blood profiles
    Lucsame Gruneck, Niwed Kullawong, Kongkiat Kespechara, Siam Popluechai
    PeerJ.2020; 8: e9622.     CrossRef
  • Multistate Models to Predict Development of Late Complications of Type 2 Diabetes in an Open Cohort Study


    Roqayeh Aliyari, Ebrahim Hajizadeh, Ashraf Aminorroaya, Farshad Sharifi, Iraj Kazemi, Ahmad-Reza Baghestani
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2020; Volume 13: 1863.     CrossRef
  • Early weaning induces short‐ and long‐term effects on pancreatic islets in Wistar rats of both sexes
    Carla Bruna Pietrobon, Rosiane Aparecida Miranda, Iala Milene Bertasso, Paulo Cezar de Freitas Mathias, Maria Lúcia Bonfleur, Sandra Lucinei Balbo, Marise Auxiliadora de Barros Reis, Márcia Queiroz Latorraca, Vanessa Cristina Arantes, Elaine de Oliveira,
    The Journal of Physiology.2020; 598(3): 489.     CrossRef
  • A negative impact of recent weight loss on in-hospital mortality is not modified by overweight and obesity
    Rocco Barazzoni, Isabella Sulz, Karin Schindler, Stephan C. Bischoff, Gianluca Gortan Cappellari, Michael Hiesmayr
    Clinical Nutrition.2020; 39(8): 2510.     CrossRef
  • Body mass index and mortality among middle-aged Japanese individuals with diagnosed diabetes: The Japan Public Health Center-based prospective study (JPHC study)
    Chiho Yamazaki, Atsushi Goto, Motoki Iwasaki, Norie Sawada, Shino Oba, Mitsuhiko Noda, Hiroyasu Iso, Hiroshi Koyama, Shoichiro Tsugane
    Diabetes Research and Clinical Practice.2020; 164: 108198.     CrossRef
  • Is the Obesity Paradox in Type 2 Diabetes Due to Artefacts of Biases? An Analysis of Pooled Cohort Data from the Heinz Nixdorf Recall Study and the Study of Health in Pomerania


    Bernd Kowall, Andreas Stang, Raimund Erbel, Susanne Moebus, Astrid Petersmann, Antje Steveling, Karl-Heinz Jöckel, Henry Völzke
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2020; Volume 13: 1989.     CrossRef
  • Associations between BMI, waist circumference, central obesity and outcomes in type II diabetes mellitus: The ACCORD Trial
    Charles A. German, Brian Laughey, Alain G. Bertoni, Joseph Yeboah
    Journal of Diabetes and its Complications.2020; 34(3): 107499.     CrossRef
  • Trends in mechanical ventilation use and mortality over time in patients receiving mechanical ventilation in Spain from 2001 to 2015.
    Javier de-Miguel-Díez, Rodrigo Jiménez-García, Valentín Hernández-Barrera, Jose J Zamorano-Leon, Rosa Villanueva-Orbaiz, Romana Albaladejo-Vicente, Ana López-de-Andrés
    European Journal of Internal Medicine.2020; 74: 67.     CrossRef
  • Type 2 diabetes mellitus: pathogenesis and genetic diagnosis
    D. Himanshu, Wahid Ali, Mohd Wamique
    Journal of Diabetes & Metabolic Disorders.2020; 19(2): 1959.     CrossRef
  • Prevalence and factors associated with overweight and obesity among patients with type 2 diabetes mellitus in Uganda—a descriptive retrospective study
    Salome Tino, Billy N Mayanja, Michael Charles Mubiru, Emmanuel Eling, Edward Ddumba, Pontiano Kaleebu, Moffat Nyirenda
    BMJ Open.2020; 10(11): e039258.     CrossRef
  • Nutrition Therapy in Critically Ill Overweight Elderly Patient with Heart Failure, Myocardial Infarction, Pneumonia, and Chronic Kidney Disease
    Christina RUSLI, Agussalim BUKHARI, Nurpudji A. TASLIM, Suryani AS’AD, Haerani RASYID
    Journal of Nutritional Science and Vitaminology.2020; 66(Supplement): S25.     CrossRef
  • Obesity and childhood asthma
    Jason E. Lang
    Current Opinion in Pulmonary Medicine.2019; 25(1): 34.     CrossRef
  • Why primary obesity is a disease?
    Antonino De Lorenzo, Santo Gratteri, Paola Gualtieri, Andrea Cammarano, Pierfrancesco Bertucci, Laura Di Renzo
    Journal of Translational Medicine.2019;[Epub]     CrossRef
  • Impaired compensatory hyperinsulinemia among nonobese type 2 diabetes patients: a cross-sectional study
    Jit Sarkar, Sujay Krishna Maity, Abhishek Sen, Titli Nargis, Dipika Ray, Partha Chakrabarti
    Therapeutic Advances in Endocrinology and Metabolism.2019;[Epub]     CrossRef
  • Sedentary behaviour is associated with diabetes mellitus in adults: findings of a cross-sectional analysis from the Brazilian National Health System
    Ítalo Ribeiro Lemes, Xuemei Sui, Bruna Camilo Turi-Lynch, Duck-chul Lee, Steven N Blair, Rômulo Araújo Fernandes, Jamile Sanches Codogno, Henrique Luiz Monteiro
    Journal of Public Health.2019; 41(4): 742.     CrossRef
  • Obesity Paradox in Chronic Liver Diseases: Product of Bias or a Real Thing?
    Ines Bilic Curcic, Maja Cigrovski Berkovic, Lucija Kuna, Hrvoje Roguljic, Robert Smolic, Silvija Canecki Varzic, Lucija Virovic Jukic, Martina Smolic
    Journal of Clinical and Translational Hepatology.2019; 7(3): 1.     CrossRef
  • From the Obesity Tsunami to the Diabetes Avalanche: Primordial Prevention of the Diabesity-Related Cardiovascular Epidemic by Diabeto-Cardiologists
    Mustafa Karakurt, Burak Acar, Ozcan Ozeke, Mustafa Bilal Ozbay, Yasin Ozen, Sefa Unal, Mustafa Karanfil, Cagri Yayla, Serkan Cay, Orhan Maden, Dursun Aras, Serkan Topaloglu, Sinan Aydogdu, Zehra Golbasi
    Angiology.2019; 70(4): 371.     CrossRef
  • Increased Plasma Dipeptidyl Peptidase-4 (DPP4) Activity Is an Obesity-Independent Parameter for Glycemic Deregulation in Type 2 Diabetes Patients
    Jit Sarkar, Titli Nargis, Om Tantia, Sujoy Ghosh, Partha Chakrabarti
    Frontiers in Endocrinology.2019;[Epub]     CrossRef
  • INVESTIGATING INDIVIDUAL FACTORS RELATED TO READMISSION OF PATIENTS WITH TYPE 2 DIABETES- A CROSS-SECTIONAL STUDY
    Valiallah Dashtpour, Mehran Hesaraki, Mahnaz Abavisani, Mahdieh Sari, Sudabeh Ahmadidarrehsima
    Journal of Evolution of Medical and Dental Sciences.2018; 7(53): 5604.     CrossRef
The Relationship between Diabetes Mellitus and Health-Related Quality of Life in Korean Adults: The Fourth Korea National Health and Nutrition Examination Survey (2007-2009)
Yong Jun Choi, Min Suk Lee, So Yeon An, Tae Ho Kim, Seung Jin Han, Hae Jin Kim, Yoon-Sok Chung, Kwan Woo Lee, Dae Jung Kim
Diabetes Metab J. 2011;35(6):587-594.   Published online December 26, 2011
DOI: https://doi.org/10.4093/dmj.2011.35.6.587
  • 5,722 View
  • 54 Download
  • 46 Crossref
AbstractAbstract PDFPubReader   
Background

Diabetes is a major health problem in Korea. However, interest in the quality of life in patients with diabetes is low. We examined the effects of diabetes on health-related quality of life (HRQoL) and compared it with HRQoL in the general Korean population using the Fourth Korea National Health and Nutrition Examination Survey (KNHANES IV) (2007-2009).

Methods

Using KNHANES IV data, we compared EuroQol (EQ)-5D and EQ-visual analogue scale (VAS) scores after adjusting for sociodemographic and psychosocial factors as well as for comorbidities (hypertension, heart disease, stroke, arthritis, and chronic renal disease). Logistic regressions were used to explore determinants for the lowest quintile HRQoL scales in the diabetes group.

Results

The mean age of the 14,441 enrolled subjects (6,129 men and 8,312 women) was 52.5±14.5 years. The mean EQ-5D and EQ-VAS scores were significantly lower in the diabetes group (EQ-5D. 0.87; EQ-VAS, 71.94) than in the non-diabetes group (EQ-5D, 0.94; EQ-VAS, 77.40) (P<0.001). Self-reported depressive symptom had a significant effect on lowering the EQ-VAS (odds ratio [OR], 1.7; 95% confidence interval [CI], 1.1 to 2.6) in the diabetes group. Stress level had a significant effect in lowering both the EQ-5D (OR, 2.0; 95% CI, 1.3 to 2.9) and the EQ-VAS (OR, 1.9; 95% CI, 1.3 to 2.9). HbA1c, diabetes duration, and treatment modalities had no significant effect on lowering HRQoL.

Conclusion

Diabetes was clearly associated with impaired HRQoL compared with the non-diabetic population regardless of comorbidities. Therapeutic approaches should focus much more on the subjective perception of health in patients with diabetes.

Citations

Citations to this article as recorded by  
  • Health state utility values of type 2 diabetes mellitus and related complications: a systematic review and meta-regression
    Yubo Wang, Yueru Xu, Huiting Shan, Huimin Pan, Ji Chen, Jianhua Yang
    Health and Quality of Life Outcomes.2024;[Epub]     CrossRef
  • Understanding health‐related quality of life trajectories among older adults with diabetes mellitus: Mixed methods research
    Sunhee Park, Taewha Lee
    Nursing Open.2023; 10(10): 6945.     CrossRef
  • Evaluation of the Relation between Compliance with Mediterranean Diet and Quality of Life of Patients with Type 2 Diabetes
    Meltem Kudret, Fatma Nişancı Kılınç, Sevilay Karahan
    Nutrition and Cancer.2023; 75(2): 562.     CrossRef
  • The status of stigma in patients with type 2 diabetes mellitus and its association with medication adherence and quality of life in China: A cross-sectional study
    Xiaoyan Li, Lingyun Wu, Jie Yun, Qiuhua Sun
    Medicine.2023; 102(26): e34242.     CrossRef
  • Factors Influencing the Subjective Health Status of Men with Insulin-treated Type 2 Diabetes Mellitus: A Secondary Analysis Using Quantile Regression Analysis
    Kang Sun Lee, Hyuk Joon Kim, Young Man Kim, Hye Young Kim
    Journal of Korean Academy of Fundamentals of Nursing.2023; 30(4): 530.     CrossRef
  • Association of temporomandibular disorders and tinnitus with health‐related quality of life: A cross‐sectional study using the Fifth Korea National Health and Nutrition Examination Survey
    Geon‐Sik Kong, Sook‐Hyun Lee, Kyoung Sun Park, Jae‐Heung Cho, Koh‐Woon Kim, In‐Hyuk Ha
    Journal of Oral Rehabilitation.2022; 49(3): 283.     CrossRef
  • Health-related quality of life of patients with type 2 diabetes mellitus at a tertiary care hospital in Ethiopia
    Girma Tekle Gebremariam, Selam Biratu, Metasebia Alemayehu, Abraham Gebregziabiher Welie, Kebede Beyene, Beate Sander, Gebremedhin Beedemariam Gebretekle, Vijayaprakash Suppiah
    PLOS ONE.2022; 17(2): e0264199.     CrossRef
  • The role of nutritional status in the relationship between diabetes and health-related quality of life
    Sohyun Park, Sukyoung Jung, Hyunsook Yoon
    Nutrition Research and Practice.2022; 16(4): 505.     CrossRef
  • Associations between Food Groups and Health-Related Quality of Life in Korean Adults
    Shamirah Nabbosa, Sunghee Lee
    Nutrients.2022; 14(17): 3643.     CrossRef
  • Quality of life among adult patients living with diabetes in Rwanda: a cross-sectional study in outpatient clinics
    Charilaos Lygidakis, Jean Paul Uwizihiwe, Michela Bia, Francois Uwinkindi, Per Kallestrup, Claus Vögele
    BMJ Open.2021; 11(2): e043997.     CrossRef
  • THE RELATIONSHIP BETWEEN SELF-MANAGEMENT AND QUALITY OF LIFE AMONG PATIENTS WITH TYPE 2 DIABETES MELLITUS
    Ninik Ambar Sari, Ceria Nurhayati
    Nurse and Health: Jurnal Keperawatan.2021; 10(2): 343.     CrossRef
  • Measurement of health-related quality of life in patients with diabetes mellitus using EQ-5D-5L in Hong Kong, China
    Eliza Lai yi Wong, Richard Huan Xu, Annie Wai ling Cheung
    Quality of Life Research.2020; 29(7): 1913.     CrossRef
  • Non-Exercise Based Estimation of Cardiorespiratory Fitness Mediates Associations between Comorbidities and Health-Related Quality of Life in Older Korean Adults with Diabetes
    Inhwan Lee, Shinuk Kim, Hyunsik Kang
    International Journal of Environmental Research and Public Health.2020; 17(4): 1164.     CrossRef
  • Health related quality of life and healthcare utilization among adults with diabetes and kidney and eye complications in the United States
    Abdulkarim M. Meraya, Monira Alwhaibi
    Health and Quality of Life Outcomes.2020;[Epub]     CrossRef
  • Limitations of Deep Learning Attention Mechanisms in Clinical Research: Empirical Case Study Based on the Korean Diabetic Disease Setting
    Junetae Kim, Sangwon Lee, Eugene Hwang, Kwang Sun Ryu, Hanseok Jeong, Jae Wook Lee, Yul Hwangbo, Kui Son Choi, Hyo Soung Cha
    Journal of Medical Internet Research.2020; 22(12): e18418.     CrossRef
  • Predictors of Health-Related Quality of Life in Korean Adults with Diabetes Mellitus
    Mihyun Jeong
    International Journal of Environmental Research and Public Health.2020; 17(23): 9058.     CrossRef
  • Diabetes Fact Sheet in Korea, 2016: An Appraisal of Current Status
    Jong Chul Won, Jae Hyuk Lee, Jae Hyeon Kim, Eun Seok Kang, Kyu Chang Won, Dae Jung Kim, Moon-Kyu Lee
    Diabetes & Metabolism Journal.2018; 42(5): 415.     CrossRef
  • Does ancestry influence health-related quality of life in type 1 diabetes patients? A nationwide study in Brazil
    Deborah Conte Santos, Marcela Haas Pizarro, Bianca S. V. Barros, Laura G. Nunes de Melo, Luis Cristovão Porto, Dayse A. Silva, Marilia Brito Gomes
    Acta Diabetologica.2018; 55(4): 377.     CrossRef
  • Lipid profiles in adolescents with and without asthma: Korea National Health and nutrition examination survey data
    Sun-Hye Ko, Jaewook Jeong, Myong Ki Baeg, Kyung-Do Han, Hwan Soo Kim, Jong-seo Yoon, Hyun Hee Kim, Jin Tack Kim, Yoon Hong Chun
    Lipids in Health and Disease.2018;[Epub]     CrossRef
  • Evaluation of Health Status of Type 2 Diabetes Outpatients Receiving Care in a Tertiary Hospital in Nigeria
    Maxwell Ogochukwu Adibe, Chibueze Anosike, Sunday Odunke Nduka, Abdulmuminu Isah
    PharmacoEconomics - Open.2018; 2(3): 337.     CrossRef
  • Association between chronic conditions and health-related quality of life: differences by level of urbanization in Peru
    Alvaro Taype-Rondan, Elizabeth Sarah Abbs, Maria Lazo-Porras, William Checkley, Robert H. Gilman, Liam Smeeth, J. Jaime Miranda, Antonio Bernabe-Ortiz
    Quality of Life Research.2017; 26(12): 3439.     CrossRef
  • The impact of weight misperception on health-related quality of life in Korean adults (KNHANES 2007–2014): a community-based cross-sectional study
    Susan Park, Sejin Lee, Jinseub Hwang, Jin-Won Kwon
    BMJ Open.2017; 7(6): e016098.     CrossRef
  • Self-efficacy and self-care behaviours among adults with type 2 diabetes
    Melba Sheila D'Souza, Subrahmanya Nairy Karkada, Kader Parahoo, Ramesh Venkatesaperumal, Susan Achora, Arcalyd Rose R. Cayaban
    Applied Nursing Research.2017; 36: 25.     CrossRef
  • Factors associated with health-related quality of life in Koreans aged over 50 Years: the fourth and fifth Korea National Health and Nutrition Examination Survey
    Kyoung Min Kwon, Jung Soo Lee, Na Eun Jeon, Yeo Hyung Kim
    Health and Quality of Life Outcomes.2017;[Epub]     CrossRef
  • Quality of Life in Patients with Osteoporotic Vertebral Compression Fractures
    Ho Jin Jung, Ye-Soo Park, Hyoung-Yeon Seo, Jae-Chul Lee, Ki-Chan An, Jin-Hyok Kim, Byung-Joon Shin, Tae Wook Kang, Si Young Park
    Journal of Bone Metabolism.2017; 24(3): 187.     CrossRef
  • Health Related Quality of Life among Omani Men and Women with Type 2 Diabetes
    Melba Sheila D’Souza, Ramesh Venkatesaperumal, Susan D. Ruppert, Subrahmanya Nairy Karkada, Devakirubai Jacob
    Journal of Diabetes Research.2016; 2016: 1.     CrossRef
  • Heavy Alcohol Consumption with Alcoholic Liver Disease Accelerates Sarcopenia in Elderly Korean Males: The Korean National Health and Nutrition Examination Survey 2008-2010
    Do Seon Song, U Im Chang, Sooa Choi, Yun Duk Jung, Kyungdo Han, Seung-Hyun Ko, Yu-Bae Ahn, Jin Mo Yang, Masaki Mogi
    PLOS ONE.2016; 11(9): e0163222.     CrossRef
  • Negative effect of a previous diagnosis of diabetes on quality of life in a Japanese population: The Gifu Diabetes Study
    Yukiko Nonoyama, Mayumi Yamamoto, Shino Oba, Chisato Nagata, Kazuki Matsui, Jun Takeda
    Diabetology International.2016; 7(2): 148.     CrossRef
  • The impact of type 2 diabetes on health related quality of life in Bangladesh: results from a matched study comparing treated cases with non-diabetic controls
    Novie Safita, Sheikh Mohammed Shariful Islam, Clara K. Chow, Louis Niessen, Andreas Lechner, Rolf Holle, Michael Laxy
    Health and Quality of Life Outcomes.2016;[Epub]     CrossRef
  • Utilities for Type 2 Diabetes Treatment-Related Attributes in a South Korean and Taiwanese Population
    Narayan Rajan, Kristina S. Boye, Meaghan Gibbs, Yoon Ji Lee, Peter Davey, Mark Ball, Steve M. Babineaux
    Value in Health Regional Issues.2016; 9: 67.     CrossRef
  • Knowledge, attitudes, and quality of life of type 2 diabetes patients in Riyadh, Saudi Arabia
    IbrahimSuliman Al-Aboudi, MohammedAzmi Hassali, AsrulAkmal Shafie
    Journal of Pharmacy And Bioallied Sciences.2016; 8(3): 195.     CrossRef
  • Low muscle mass is associated with metabolic syndrome only in nonobese young adults: the Korea National Health and Nutrition Examination Survey 2008-2010
    Byung Chul Kim, Mee Kyoung Kim, Kyungdo Han, Sae-Young Lee, Seung-Hwan Lee, Seung-Hyun Ko, Hyuk-Sang Kwon, Anwar T. Merchant, Hyeon Woo Yim, Won-Chul Lee, Yong Gyu Park, Yong-Moon Park
    Nutrition Research.2015; 35(12): 1070.     CrossRef
  • Insulin Resistance Is Associated with Intraocular Pressure Elevation in a Non-Obese Korean Population
    Yoon Hong Chun, Kyungdo Han, Shin Hae Park, Kyung-Min Park, Hyeon Woo Yim, Won-Chul Lee, Yong Gyu Park, Yong-Moon Park, Stephen L. Atkin
    PLoS ONE.2015; 10(1): e112929.     CrossRef
  • Sarcopenia as a Determinant of Blood Pressure in Older Koreans: Findings from the Korea National Health and Nutrition Examination Surveys (KNHANES) 2008–2010
    Kyungdo Han, Yu-Mi Park, Hyuk-Sang Kwon, Seung-Hyun Ko, Seung-Hwan Lee, Hyeon Woo Yim, Won-Chul Lee, Yong Gyu Park, Mee Kyoung Kim, Yong-Moon Park, Yan Li
    PLoS ONE.2014; 9(1): e86902.     CrossRef
  • Suicidal ideation and suicide attempts among diabetes mellitus: The Korea National Health and Nutrition Examination Survey (KNHANES IV, V) from 2007 to 2012
    Jae Ho Chung, Kitae Moon, Do Hyung Kim, Joo-Won Min, Tae Ho Kim, Hee-Jin Hwang
    Journal of Psychosomatic Research.2014; 77(6): 457.     CrossRef
  • Diabetes and Depressive Symptoms in Korean Women: The Fifth Korean National Health and Nutrition Examination Survey (2010-2011)
    Han Na Sung, Hong Seok Chae, Eung Soo Kim, Jong Sung Kim
    Korean Journal of Family Medicine.2014; 35(3): 127.     CrossRef
  • Factors Associated with Hemorrhoids in Korean Adults: Korean National Health and Nutrition Examination Survey
    Jong-Hyun Lee, Hyo-Eun Kim, Ji-Hun Kang, Jin-Young Shin, Yun-Mi Song
    Korean Journal of Family Medicine.2014; 35(5): 227.     CrossRef
  • The Health Technology Assessment Environment in Mainland China, Japan, South Korea, and Taiwan—Implications for the Evaluation of Diabetes Mellitus Therapies
    Tessa Kennedy-Martin, Beth D. Mitchell, Kristina S. Boye, Wen Chen, Bradley H. Curtis, Jennifer A. Flynn, Shunya Ikeda, Li Liu, Yen Huei Tarn, Bong-Min Yang, Emmanuel Papadimitropoulos
    Value in Health Regional Issues.2014; 3: 108.     CrossRef
  • Can “Healthy” Normal Alanine Aminotransferase Levels Identify the Metabolically Obese Phenotype? Findings from The Korea National Health and Nutrition Examination Survey 2008–2010
    Hee Yeon Kim, Chang Wook Kim, Chang Don Lee, Jong Young Choi, Chung-Hwa Park, Si Hyun Bae, Seung Kew Yoon, Kyungdo Han, Yong-Moon Park
    Digestive Diseases and Sciences.2014; 59(6): 1330.     CrossRef
  • The impact of new screen-detected and previously known type 2 diabetes on health-related quality of life: a population-based study in Qingdao, China
    Yanlei Zhang, Jianping Sun, Zengchang Pang, Xiaoyong Wang, Weiguo Gao, Feng Ning, Jie Ren, Anil Kapur, Harri Sintonen, Qing Qiao
    Quality of Life Research.2014; 23(8): 2319.     CrossRef
  • Increasing achievement of the target goals for glycemic, blood pressure and lipid control for adults with diagnosed diabetes in Korea
    Sung Hoon Yu, Jun Goo Kang, Yoo‐Cheol Hwang, Kyu Jeung Ahn, Hyung Joon Yoo, Hong Yup Ahn, Sung Woo Park, Cheol‐Young Park
    Journal of Diabetes Investigation.2013; 4(5): 460.     CrossRef
  • Psychosocial needs of cancer patients and related factors: a multi‐center, cross‐sectional study in Korea
    Kyung‐Hyun Choi, Jae‐Hyun Park, Jong‐Hyock Park, Joo‐Sung Park
    Psycho-Oncology.2013; 22(5): 1073.     CrossRef
  • Correlates of health-related quality of life in French people with type 2 diabetes
    I. Bourdel-Marchasson, C. Druet, C. Helmer, E. Eschwege, P. Lecomte, M. Le-Goff, A.J. Sinclair, A. Fagot-Campagna
    Diabetes Research and Clinical Practice.2013; 101(2): 226.     CrossRef
  • Diet Therapy in Patients of Diabetic Nephropathy
    Ji-Youn Kim
    The Journal of Korean Diabetes.2013; 14(1): 27.     CrossRef
  • Health‐related quality of life among Tianjin Chinese patients with type 2 diabetes: A cross‐sectional survey
    Ji‐Yan Cong, Yue Zhao, Qun‐Yan Xu, Chun‐De Zhong, Qiu‐Ling Xing
    Nursing & Health Sciences.2012; 14(4): 528.     CrossRef
  • Effects of Frequency of Follow-Up on Quality of Life of Type 2 Diabetes Patients on Oral Hypoglycemics
    Ming Hu, Zhiguang Zhou, Fang Zeng, Zhenqiu Sun
    Diabetes Technology & Therapeutics.2012; 14(9): 777.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal
Close layer
TOP