Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal

Search
OPEN ACCESS

Author index

Page Path
HOME > Browse > Author index
Search
Seon-Ah Cha  (Cha SA) 4 Articles
Metabolic Risk/Epidemiology
Short-Term Effects of the Internet-Based Korea Diabetes Prevention Study: 6-Month Results of a Community-Based Randomized Controlled Trial
Jin-Hee Lee, Sun-Young Lim, Seon-Ah Cha, Chan-Jung Han, Ah Reum Jung, Kook-Rye Kim, Kun-Ho Yoon, Seung-Hyun Ko
Diabetes Metab J. 2021;45(6):960-965.   Published online March 17, 2021
DOI: https://doi.org/10.4093/dmj.2020.0225
  • 5,311 View
  • 150 Download
  • 5 Web of Science
  • 6 Crossref
Graphical AbstractGraphical Abstract AbstractAbstract PDFPubReader   ePub   
The aims of this study were to determine the short-term effectiveness of an internet-based lifestyle modification (LSM) program in preventing the onset of type 2 diabetes mellitus (T2DM) in prediabetes patients in community settings. A total of 415 subjects who were diagnosed with prediabetes were randomly assigned to the LSM and standard management (SM) groups. After the 6-month intervention, the LSM group had a statistically significant reduction in body weight, body mass index compared to the SM group participants. In the LSM group, blood glucose levels were significantly decreased after intervention and the clinical improvement effect was evident in the group that achieved the target weight loss of 5% or more of the initial weight for 6 months. Internet-based 6-month-intensive LSM programs conducted by public health center personnel are an effective way to provide lifestyle intervention programs and encourage maintenance of healthy behaviors in subjects with a high risk of T2DM in community settings.

Citations

Citations to this article as recorded by  
  • U-shaped association between online information exchange and app usage frequency: a large-scale survey of China ‘s online young and middle-aged people with pre diabetes and diabetes
    Hanbin Guo, Yibiao Xiao, Canlin Liao, Jiating Sun, Yanchun Xie, Yitong Zheng, Guanhua Fan
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Innovation in diabetes prevention research: The 36-year legacy of China Da Qing diabetes prevention study
    Xin Chai, Yachen Wang, Jinping Wang, Qiuhong Gong, Juan Zhang, Ruitai Shao
    Chinese Science Bulletin.2023; 68(28-29): 3834.     CrossRef
  • Efficacy of Personalized Diabetes Self-care Using an Electronic Medical Record–Integrated Mobile App in Patients With Type 2 Diabetes: 6-Month Randomized Controlled Trial
    Eun Young Lee, Seon-Ah Cha, Jae-Seung Yun, Sun-Young Lim, Jin-Hee Lee, Yu-Bae Ahn, Kun-Ho Yoon, Min Kyung Hyun, Seung-Hyun Ko
    Journal of Medical Internet Research.2022; 24(7): e37430.     CrossRef
  • Prevention of type 2 diabetes through remotely administered lifestyle programs: A systematic review
    Valaree Villegas, Alisha Shah, JoAnn E. Manson, Deirdre K. Tobias
    Contemporary Clinical Trials.2022; 119: 106817.     CrossRef
  • 2021 Clinical Practice Guidelines for Diabetes Mellitus of the Korean Diabetes Association
    Kyu Yeon Hur, Min Kyong Moon, Jong Suk Park, Soo-Kyung Kim, Seung-Hwan Lee, Jae-Seung Yun, Jong Ha Baek, Junghyun Noh, Byung-Wan Lee, Tae Jung Oh, Suk Chon, Ye Seul Yang, Jang Won Son, Jong Han Choi, Kee Ho Song, Nam Hoon Kim, Sang Yong Kim, Jin Wha Kim,
    Diabetes & Metabolism Journal.2021; 45(4): 461.     CrossRef
  • 2021 Clinical Practice Guidelines for Diabetes Mellitus in Korea
    Seung-Hyun Ko
    The Journal of Korean Diabetes.2021; 22(4): 244.     CrossRef
Complications
Baseline-Corrected QT (QTc) Interval Is Associated with Prolongation of QTc during Severe Hypoglycemia in Patients with Type 2 Diabetes Mellitus
Seon-Ah Cha, Jae-Seung Yun, Tae-Seok Lim, Yoon-Goo Kang, Kang-Min Lee, Ki-Ho Song, Ki-Dong Yoo, Yong-Moon Park, Seung-Hyun Ko, Yu-Bae Ahn
Diabetes Metab J. 2016;40(6):463-472.   Published online October 5, 2016
DOI: https://doi.org/10.4093/dmj.2016.40.6.463
  • 3,623 View
  • 47 Download
  • 10 Web of Science
  • 10 Crossref
AbstractAbstract PDFPubReader   
Background

We investigated an association between baseline heart rate-corrected QT (QTc) interval before severe hypoglycemia (SH) and prolongation of QTc interval during SH in patients with type 2 diabetes mellitus (T2DM).

Methods

Between January 2004 and June 2014, 208 patients with T2DM, who visited the emergency department because of SH and underwent standard 12-lead electrocardiography within the 6-month period before SH were consecutively enrolled. The QTc interval was analyzed during the incidence of SH, and 6 months before and after SH. QTc intervals of 450 ms or longer in men and 460 ms or longer in women were considered abnormally prolonged.

Results

The mean age and diabetes duration were 68.1±12.1 and 14.1±10.1 years, respectively. The mean QTc intervals at baseline and SH episodes were 433±33 and 460±33 ms, respectively (P<0.001). One hundred and fourteen patients (54.8%) had a prolonged QTc interval during SH. There was a significant decrease in the prolonged QTc interval within 6 months after SH (QTc interval prolongation during SH vs. after recovery, 54.8% vs. 33.8%, P<0.001). The prolonged QTc interval was significantly associated with baseline QTc interval prolongation (odds ratio, 2.92; 95% confidence interval, 1.22 to 6.96; P=0.016) after adjusting for multiple confounders.

Conclusion

A prolonged QTc interval at baseline was significantly associated with prolongation of the QTc interval during SH in patients with T2DM, suggesting the necessity of QTc interval monitoring and attention to those with a prolonged QTc interval to prevent SH.

Citations

Citations to this article as recorded by  
  • Prevalence of QT prolongation and its risk factors in patients with type 2 diabetes
    Khaled Aburisheh, Mohammad F. AlKheraiji, Saleh I. Alwalan, Arthur C. Isnani, Mohamed Rafiullah, Muhammad Mujammami, Assim A. Alfadda
    BMC Endocrine Disorders.2023;[Epub]     CrossRef
  • U-shaped association between the triglyceride–glucose index and atrial fibrillation incidence in a general population without known cardiovascular disease
    Xiao Liu, Ayiguli Abudukeremu, Yuan Jiang, Zhengyu Cao, Maoxiong Wu, Jianyong Ma, Runlu Sun, Wanbing He, Zhiteng Chen, Yangxin Chen, Peng Yu, Wengen Zhu, Yuling Zhang, Jingfeng Wang
    Cardiovascular Diabetology.2023;[Epub]     CrossRef
  • Celebrities in the heart, strangers in the pancreatic beta cell: Voltage‐gated potassium channels Kv7.1 and Kv11.1 bridge long QT syndrome with hyperinsulinaemia as well as type 2 diabetes
    Anniek F. Lubberding, Christian R. Juhl, Emil Z. Skovhøj, Jørgen K. Kanters, Thomas Mandrup‐Poulsen, Signe S. Torekov
    Acta Physiologica.2022;[Epub]     CrossRef
  • Severe hypoglycemia as a risk factor for cardiovascular outcomes in patients with type 2 diabetes: is it preventable?
    Seung-Hyun Ko
    Cardiovascular Prevention and Pharmacotherapy.2022; 4(3): 106.     CrossRef
  • Heart rate-corrected QT interval prolongation is associated with decreased heart rate variability in patients with type 2 diabetes
    Seon-Ah Cha
    Medicine.2022; 101(45): e31511.     CrossRef
  • Severe hypoglycemia as a preventable risk factor for cardiovascular disease in patients with type 2 diabetes mellitus
    Soo-Yeon Choi, Seung-Hyun Ko
    The Korean Journal of Internal Medicine.2021; 36(2): 263.     CrossRef
  • Review of the cardiovascular safety of dipeptidyl peptidase-4 inhibitors and the clinical relevance of the CAROLINA trial
    Marile Santamarina, Curt J. Carlson
    BMC Cardiovascular Disorders.2019;[Epub]     CrossRef
  • Antioxidant effects of epigallocatechin-3-gallate on the aTC1-6 pancreatic alpha cell line
    Ting Cao, Xiong Zhang, Dan Yang, Yue-Qian Wang, Zheng-Dong Qiao, Jian-Ming Huang, Peng Zhang
    Biochemical and Biophysical Research Communications.2018; 495(1): 693.     CrossRef
  • Severe hypoglycemia is a risk factor for atrial fibrillation in type 2 diabetes mellitus: Nationwide population-based cohort study
    Seung-Hyun Ko, Yong-Moon Park, Jae-Seung Yun, Seon-Ah Cha, Eue-Keun Choi, Kyungdo Han, Eugene Han, Yong-ho Lee, Yu-Bae Ahn
    Journal of Diabetes and its Complications.2018; 32(2): 157.     CrossRef
  • Incidence of prolonged QTc and severe hypoglycemia in type 1 diabetes: the EURODIAB Prospective Complications Study
    Cristina Amione, Sara Giunti, Paolo Fornengo, Sabita S. Soedamah-Muthu, Nish Chaturvedi, J. H. Fuller, Federica Barutta, Gabriella Gruden, Graziella Bruno
    Acta Diabetologica.2017; 54(9): 871.     CrossRef
Complications
Clinical Course and Risk Factors of Diabetic Retinopathy in Patients with Type 2 Diabetes Mellitus in Korea
Jae-Seung Yun, Tae-Seok Lim, Seon-Ah Cha, Yu-Bae Ahn, Ki-Ho Song, Jin A Choi, Jinwoo Kwon, Donghyun Jee, Yang Kyung Cho, Yong-Moon Park, Seung-Hyun Ko
Diabetes Metab J. 2016;40(6):482-493.   Published online October 5, 2016
DOI: https://doi.org/10.4093/dmj.2016.40.6.482
  • 4,466 View
  • 61 Download
  • 30 Web of Science
  • 34 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   
Background

We investigated clinical course and risk factors for diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM).

Methods

A total of 759 patients with T2DM without DR were included from January 2001 to December 2004. Retinopathy evaluation was performed at least annually by ophthalmologists. The severity of the DR was classified into five categories according to the International Clinical Diabetic Retinopathy Severity Scales.

Results

Of the 759 patients, 523 patients (68.9%) completed the follow-up evaluation. During the follow-up period, 235 patients (44.9%) developed DR, and 32 patients (13.6%) progressed to severe nonproliferative DR (NPDR) or proliferative DR (PDR). The mean duration of diabetes at the first diagnosis of mild NPDR, moderate NPDR, and severe NPDR or PDR were 14.8, 16.7, and 17.3 years, respectively. After adjusting multiple confounding factors, the significant risk factors for the incidence of DR risk in patients with T2DM were old age, longer duration of diabetes, higher mean glycosylated hemoglobin (HbA1c), and albuminuria. Even in the patients who had been diagnosed with diabetes for longer than 10 years at baseline, a decrease in HbA1c led to a significant reduction in the risk of developing DR (hazard ratio, 0.73 per 1% HbA1c decrement; 95% confidence interval, 0.58 to 0.91; P=0.005).

Conclusion

This prospective cohort study demonstrates that glycemic control, diabetes duration, age, and albuminuria are important risk factors for the development of DR. More aggressive retinal screening for T2DM patients diagnosed with DR should be required in order to not miss rapid progression of DR.

Citations

Citations to this article as recorded by  
  • Prevalence of diabetes and its correlates among Iranian adults: Results of the first phase of Shahedieh cohort study
    Ali Dehghani, Hamid Korozhdehi, Saeid Hossein Khalilzadeh, Hossein Fallahzadeh, Vahid Rahmanian
    Health Science Reports.2023;[Epub]     CrossRef
  • Deep learning-based fundus image analysis for cardiovascular disease: a review
    Symon Chikumba, Yuqian Hu, Jing Luo
    Therapeutic Advances in Chronic Disease.2023;[Epub]     CrossRef
  • Effect of anticoagulant/antiplatelet therapy on the development and progression of diabetic retinopathy
    Chi-Juei Jeng, Yi-Ting Hsieh, Cheng-Li Lin, I-Jong Wang
    BMC Ophthalmology.2022;[Epub]     CrossRef
  • A deep learning model for screening type 2 diabetes from retinal photographs
    Jae-Seung Yun, Jaesik Kim, Sang-Hyuk Jung, Seon-Ah Cha, Seung-Hyun Ko, Yu-Bae Ahn, Hong-Hee Won, Kyung-Ah Sohn, Dokyoon Kim
    Nutrition, Metabolism and Cardiovascular Diseases.2022; 32(5): 1218.     CrossRef
  • Risk factor analysis and clinical decision tree model construction for diabetic retinopathy in Western China
    Yuan-Yuan Zhou, Tai-Cheng Zhou, Nan Chen, Guo-Zhong Zhou, Hong-Jian Zhou, Xing-Dong Li, Jin-Rui Wang, Chao-Fang Bai, Rong Long, Yu-Xin Xiong, Ying Yang
    World Journal of Diabetes.2022; 13(11): 986.     CrossRef
  • Association of Non-Alcoholic Fatty Liver Dis-ease and Diabetic Retinopathy in Patients with Type 2 Diabetes Mellitus: a Cross-Sectional Study
    Zahra Heidari, Zahra Sharafi
    Iranian South Medical Journal.2022; 25(1): 30.     CrossRef
  • The Related Risk Factors of Diabetic Retinopathy in Elderly Patients with Type 2 Diabetes Mellitus: A Hospital-Based Cohort Study in Taiwan
    Tsai-Tung Chiu, Tien-Lung Tsai, Mei-Yin Su, Tsan Yang, Peng-Lin Tseng, Yau-Jiunn Lee, Chao-Hsien Lee
    International Journal of Environmental Research and Public Health.2021; 18(1): 307.     CrossRef
  • Association of non‐alcoholic fatty liver disease with diabetic retinopathy in type 2 diabetic patients: A meta‐analysis of observational studies
    Dandan Song, Chengqian Li, Zhongchao Wang, Yuhang Zhao, Baoming Shen, Wenjuan Zhao
    Journal of Diabetes Investigation.2021; 12(8): 1471.     CrossRef
  • PREVALENCE OF ADVANCED DIABETIC EYE DISEASE AND ITS ASSOCIATED RISK FACTORS IN TYPE 2 DIABETES MELLITUS
    Likathung Ngullie, Bratatee Roy, Sayantan Ghosh, Sneha Jain, Lakshmi Kanta Mondal
    INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH.2021; : 25.     CrossRef
  • Progression of Diabetic Retinopathy and Declining Renal Function in Patients with Type 2 Diabetes
    AJin Cho, Hayne Cho Park, Young-Ki Lee, Young Joo Shin, So Hyun Bae, Hakyoung Kim
    Journal of Diabetes Research.2020; 2020: 1.     CrossRef
  • First nation-wide study of diabetic retinopathy in Poland in the years 2013–2017
    Milena Kozioł, Michał S. Nowak, Monika Udziela, Paweł Piątkiewicz, Iwona Grabska-Liberek, Jacek P. Szaflik
    Acta Diabetologica.2020; 57(10): 1255.     CrossRef
  • Awareness of diabetic retinopathy among Saudis with diabetes type 2 in Riyadh city
    YousefM Alluhaymid, FawzanY Alotaibi, AbdulmajeedB Alotaibi, AbdullahM Albasha, AbdulrahmanS Alnaim, EssaM Sabi, AhmedH Mujamammi
    Journal of Family Medicine and Primary Care.2020; 9(8): 4229.     CrossRef
  • Relationship between Clinical Features of Diabetic Retinopathy and Systemic Factors in Patients with Newly Diagnosed Type II Diabetes Mellitus
    Hyeseong Hwang, Jin Young Kim, Tae Keun Oh, Ju Byung Chae, Dong Yoon Kim
    Journal of Korean Medical Science.2020;[Epub]     CrossRef
  • Longitudinal Screening for Diabetic Retinopathy in a Nationwide Screening Program: Comparing Deep Learning and Human Graders
    Jirawut Limwattanayingyong, Variya Nganthavee, Kasem Seresirikachorn, Tassapol Singalavanija, Ngamphol Soonthornworasiri, Varis Ruamviboonsuk, Chetan Rao, Rajiv Raman, Andrzej Grzybowski, Mike Schaekermann, Lily H. Peng, Dale R. Webster, Christopher Semtu
    Journal of Diabetes Research.2020; 2020: 1.     CrossRef
  • Protective factors for diabetic retinopathy in Type 2 diabetes mellitus patients: Long duration of no less than 10 years
    Yanli Liu, Chunwen Duan, Dejia Fang, Yi Liu, Hanchun Xu, Yarong Zheng, Yaling Xuan, Lili Wang, Lin Ye, Rui Su, Meixia An
    Journal of Diabetes and its Complications.2019; 33(10): 107383.     CrossRef
  • Incidence of sight‐threatening diabetic retinopathy in people with Type 2 diabetes mellitus and numbers needed to screen: a systematic review
    Y. Groeneveld, D. Tavenier, J.W. Blom, B.C.P. Polak
    Diabetic Medicine.2019; 36(10): 1199.     CrossRef
  • Association between spousal diabetes status and diabetic retinopathy in Chinese patients with type 2 diabetes
    Mei Yang, Yu Liu, Cuihong Wen, Beirui Wu, Xu Wan, Wei Luan, Jie Shen, Wei Liu, Jing Ma
    Diabetes and Vascular Disease Research.2019; 16(5): 474.     CrossRef
  • Presence of diabetic retinopathy is lower in type 2 diabetic patients with non-alcoholic fatty liver disease
    Meng Zhang, Li Li, Jing Chen, Bei Li, Yutao Zhan, Chuan Zhang
    Medicine.2019; 98(18): e15362.     CrossRef
  • MicroRNAs as biomarkers of diabetic retinopathy and disease progression
    Bridget Martinez, PhilipV Peplow
    Neural Regeneration Research.2019; 14(11): 1858.     CrossRef
  • Vascular changes in diabetic retinopathy—a longitudinal study in the Nile rat
    Huishi Toh, Alexander Smolentsev, Rachel V. Bozadjian, Patrick W. Keeley, Madison D. Lockwood, Ryan Sadjadi, Dennis O. Clegg, Barbara A. Blodi, Peter J. Coffey, Benjamin E. Reese, James A. Thomson
    Laboratory Investigation.2019; 99(10): 1547.     CrossRef
  • DIABETE, TABAGISMO E DISASSUEFAZIONE DAL FUMO
    Davide Campagna, Angela Alamo, Enrico Mondati, Riccardo Polosa
    il Diabete.2019; 31(N. 1, marz): 41.     CrossRef
  • Smoking and diabetes: dangerous liaisons and confusing relationships
    D. Campagna, A. Alamo, A. Di Pino, C. Russo, A. E. Calogero, F. Purrello, R. Polosa
    Diabetology & Metabolic Syndrome.2019;[Epub]     CrossRef
  • Letter: Dipeptidyl Peptidase-4 Inhibitors versus Other Antidiabetic Drugs Added to Metformin Monotherapy in Diabetic Retinopathy Progression: A Real World-Based Cohort Study (Diabetes Metab J 2019;43:640–8)
    Jun Sung Moon
    Diabetes & Metabolism Journal.2019; 43(6): 911.     CrossRef
  • Past and Current Status of Adult Type 2 Diabetes Mellitus Management in Korea: A National Health Insurance Service Database Analysis
    Seung-Hyun Ko, Kyungdo Han, Yong-ho Lee, Junghyun Noh, Cheol-Young Park, Dae-Jung Kim, Chang Hee Jung, Ki-Up Lee, Kyung-Soo Ko
    Diabetes & Metabolism Journal.2018; 42(2): 93.     CrossRef
  • Excess visceral adiposity is associated with diabetic retinopathy in a multiethnic Asian cohort with longstanding type 2 diabetes
    Angela Moh, Kumari Neelam, Xiao Zhang, Chee Fang Sum, Subramaniam Tavintharan, Keven Ang, Simon Biing Ming Lee, Wern Ee Tang, Su Chi Lim
    Endocrine Research.2018; 43(3): 186.     CrossRef
  • RNA sequencing identified specific circulating miRNA biomarkers for early detection of diabetes retinopathy
    Zhen Liang, Kai P. Gao, Yi X. Wang, Zi C. Liu, Li Tian, Xin Z. Yang, Jing Y. Ding, Wei T. Wu, Wen H. Yang, Yi L. Li, Ze B. Zhang, Ri H. Zhai
    American Journal of Physiology-Endocrinology and Metabolism.2018; 315(3): E374.     CrossRef
  • High hemoglobin levels are associated with decreased risk of diabetic retinopathy in Korean type 2 diabetes
    Min-Kyung Lee, Kyung-Do Han, Jae-Hyuk Lee, Seo-Young Sohn, Jee-Sun Jeong, Mee-Kyoung Kim, Ki-Hyun Baek, Ki-Ho Song, Hyuk-Sang Kwon
    Scientific Reports.2018;[Epub]     CrossRef
  • Cigarette Smoking, Diabetes, and Diabetes Complications: Call for Urgent Action
    Ping Zhu, Xiong-Fei Pan, Liting Sheng, Henggui Chen, An Pan
    Current Diabetes Reports.2017;[Epub]     CrossRef
  • Response: Features of Long-Standing Korean Type 2 Diabetes Mellitus Patients with Diabetic Retinopathy: A Study Based on Standardized Clinical Data (Diabetes Metab J 2017;41:393-404)
    Sang Youl Rhee, Jeong-Taek Woo
    Diabetes & Metabolism Journal.2017; 41(6): 494.     CrossRef
  • Letter: Clinical Course and Risk Factors of Diabetic Retinopathy in Patients with Type 2 Diabetes Mellitus in Korea (Diabetes Metab J2016;40:482-93)
    Nam Hoon Kim
    Diabetes & Metabolism Journal.2017; 41(1): 75.     CrossRef
  • Combined treatment of diabetic nephropathy with alprostadil and calcium dobesilate
    Lili Qin, Wenjun Qin, Jianfei Wang, Lin Lin
    Experimental and Therapeutic Medicine.2017;[Epub]     CrossRef
  • Response: Clinical Course and Risk Factors of Diabetic Retinopathy in Patients with Type 2 Diabetes Mellitus in Korea (Diabetes Metab J2016;40:482-93)
    Jae-Seung Yun, Seung-Hyun Ko
    Diabetes & Metabolism Journal.2017; 41(1): 77.     CrossRef
  • Clinical characteristics and risk factors for retinal diabetic neurodegeneration in type 2 diabetes
    Kiyoung Kim, Eung Suk Kim, Sang Youl Rhee, Suk Chon, Jeong-taek Woo, Seung-Young Yu
    Acta Diabetologica.2017; 54(11): 993.     CrossRef
  • Letter: Features of Long-Standing Korean Type 2 Diabetes Mellitus Patients with Diabetic Retinopathy: A Study Based on Standardized Clinical Data (Diabetes Metab J 2017;41:393-404)
    Jae-Seung Yun
    Diabetes & Metabolism Journal.2017; 41(6): 492.     CrossRef
Complications
Severe Hypoglycemia and Cardiovascular or All-Cause Mortality in Patients with Type 2 Diabetes
Seon-Ah Cha, Jae-Seung Yun, Tae-Seok Lim, Seawon Hwang, Eun-Jung Yim, Ki-Ho Song, Ki-Dong Yoo, Yong-Moon Park, Yu-Bae Ahn, Seung-Hyun Ko
Diabetes Metab J. 2016;40(3):202-210.   Published online April 5, 2016
DOI: https://doi.org/10.4093/dmj.2016.40.3.202
  • 4,411 View
  • 60 Download
  • 48 Web of Science
  • 56 Crossref
AbstractAbstract PDFPubReader   
Background

We investigated the association between severe hypoglycemia (SH) and the risk of cardiovascular (CV) or all-cause mortality in patients with type 2 diabetes.

Methods

The study included 1,260 patients aged 25 to 75 years with type 2 diabetes from the Vincent Type 2 Diabetes Resgistry (VDR), who consecutively enrolled (n=1,260) from January 2000 to December 2010 and were followed up until May 2015 with a median follow-up time of 10.4 years. Primary outcomes were death from any cause or CV death. We investigated the association between the CV or all-cause mortality and various covariates using Cox proportional hazards regression analysis.

Results

Among the 906 participants (71.9%) who completed follow-up, 85 patients (9.4%) had at least one episode of SH, and 86 patients (9.5%) died (9.1 per 1,000 patient-years). Patients who had died were older, had a longer duration of diabetes and hypertension, received more insulin, and had more diabetic microvascular complications at baseline, as compared with surviving patients. The experience of SH was significantly associated with an increased risk of all-cause mortality (hazard ratio [HR], 2.64; 95% confidence interval [CI], 1.39 to 5.02; P=0.003) and CV mortality (HR, 6.34; 95% CI, 2.02 to 19.87; P=0.002) after adjusting for sex, age, diabetic duration, hypertension, mean glycosylated hemoglobin levels, diabetic nephropathy, lipid profiles, and insulin use.

Conclusion

We found a strong association between SH and increased risk of all-cause and CV mortality in patients with type 2 diabetes.

Citations

Citations to this article as recorded by  
  • The prognostic value of the stress hyperglycemia ratio for all-cause and cardiovascular mortality in patients with diabetes or prediabetes: insights from NHANES 2005–2018
    Lei Ding, Hongda Zhang, Cong Dai, Aikai Zhang, Fengyuan Yu, Lijie Mi, Yingjie Qi, Min Tang
    Cardiovascular Diabetology.2024;[Epub]     CrossRef
  • Association of hypoglycaemia with the risks of arrhythmia and mortality in individuals with diabetes - a systematic review and meta-analysis
    Gangfeng Li, Shuping Zhong, Xingmu Wang, Fuyuan Zhuge
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Diabetes mellitus und Straßenverkehr – ein Positionspapier der Österreichischen Diabetesgesellschaft (Update 2023)
    Heidemarie Abrahamian, Birgit Salamon, Angelika Lahnsteiner, Christian Schelkshorn, Alexander Bräuer, Lars Stechemesser, Gerd Köhler, Martin Clodi
    Wiener klinische Wochenschrift.2023; 135(S1): 319.     CrossRef
  • Validation of the hypoglycemia awareness questionnaire to assess hypoglycemia awareness in patients with type 2 diabetes treated with insulin
    Diana Cristina Henao-Carrillo, Fabio Alexander Sierra-Matamoros, Ana Julia Carrillo Algarra, Julieth Patricia García-Lugo, Sandra Milena Hernández-Zambrano
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2023; 17(12): 102917.     CrossRef
  • Basal insulin analogues in people with diabetes and chronic kidney disease
    David León‐Jiménez, José Pablo Miramontes‐González, Laura Márquez‐López, Francisco Astudillo‐Martín, Luis M. Beltrán‐Romero, Fernando Moreno‐Obregón, Javier Escalada‐San Martín
    Diabetic Medicine.2022;[Epub]     CrossRef
  • Severe Hypoglycemia Increases Dementia Risk and Related Mortality: A Nationwide, Population-based Cohort Study
    Eugene Han, Kyung-do Han, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Seung-Hyun Ko, Yong-ho Lee
    The Journal of Clinical Endocrinology & Metabolism.2022; 107(5): e1976.     CrossRef
  • Validación transcultural del HypoA-Q para medir conciencia de hipoglucemia en pacientes diabéticos
    Ana Julia Carrillo-Algarra, Sandra Milena Hernandez-Zambrano, Fabio Alexander Sierra-Matamoros, Diana Cristina Henao-Carrillo, Ana María Gómez-Medina, Daniel Esteban Hurtado-Barrera
    Revista Ciencia y Cuidado.2022; 19(1): 42.     CrossRef
  • Validity of the diagnosis of diabetic microvascular complications in Korean national health insurance claim data
    Hyung Jun Kim, Moo-Seok Park, Jee-Eun Kim, Tae-Jin Song
    Annals of Clinical Neurophysiology.2022; 24(1): 7.     CrossRef
  • Severe hypoglycemia as a risk factor for cardiovascular outcomes in patients with type 2 diabetes: is it preventable?
    Seung-Hyun Ko
    Cardiovascular Prevention and Pharmacotherapy.2022; 4(3): 106.     CrossRef
  • Evaluation of a Clinical Platform to Promote Chronic Disease Management
    Laura Greene, Nila Sathe, John A. House, Laura L. Schott, Stella Safo
    Population Health Management.2021; 24(4): 470.     CrossRef
  • Severe hypoglycemia as a preventable risk factor for cardiovascular disease in patients with type 2 diabetes mellitus
    Soo-Yeon Choi, Seung-Hyun Ko
    The Korean Journal of Internal Medicine.2021; 36(2): 263.     CrossRef
  • Meta-Analysis: Association Between Hypoglycemia and Serious Adverse Events in Older Patients Treated With Glucose-Lowering Agents
    Katharina Mattishent, Yoon K. Loke
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Epidemiology and outcomes from severe hypoglycemia in Kuwait: a prospective cohort study
    Dalal Al Hasan, Ameen Yaseen, Mohammad Al Roudan, Lee Wallis
    BMC Emergency Medicine.2021;[Epub]     CrossRef
  • The incidence of hypoglycemia and its risk factors among diabetic patients in the Eastern Province of Saudi Arabia
    Ahmed Elshebiny, Hassan Alali, Zainab Alamer, Yasmin Alsultan, Hashim Alkhalaf, Abdullah Alkishi, Mohammed Alsuwaylih
    International Journal of Medicine in Developing Countries.2021; : 614.     CrossRef
  • Current trends in epidemiology of cardiovascular disease and cardiovascular risk management in type 2 diabetes
    Jae-Seung Yun, Seung-Hyun Ko
    Metabolism.2021; 123: 154838.     CrossRef
  • Real-world Evaluation of glycemic control and hypoglycemic Events among type 2 Diabetes mellitus study (REEDS): a multicentre, cross-sectional study in Thailand
    Bancha Satirapoj, Thongchai Pratipanawatr, Boonsong Ongphiphadhanakul, Sompongse Suwanwalaikorn, Yupin Benjasuratwong, Wannee Nitiyanant
    BMJ Open.2020; 10(2): e031612.     CrossRef
  • Predictors of Diabetes Self-Care Practice Among Patients with Type 2 Diabetes in Public Hospitals in Northeastern Ethiopia: A Facility-Based Cross-Sectional Study


    Tesfaye Molla Gulentie, Ebrahim Mohammed Yesuf, Taklo Simeneh Yazie, Belayneh Kefale
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2020; Volume 13: 3137.     CrossRef
  • Hypoglycemia in Older Patients
    Byron J. Hoogwerf
    Clinics in Geriatric Medicine.2020; 36(3): 395.     CrossRef
  • Severe hypoglycaemia and absolute risk of cause-specific mortality in individuals with type 2 diabetes: a UK primary care observational study
    Francesco Zaccardi, Suping Ling, Claire Lawson, Melanie J. Davies, Kamlesh Khunti
    Diabetologia.2020; 63(10): 2129.     CrossRef
  • Insulin Glargine U100 Improved Glycemic Control and Reduced Nocturnal Hypoglycemia in Patients with Type 2 Diabetes Mellitus and Chronic Kidney Disease Stages 3 and 4
    Carolina C. Betônico, Silvia Maria O. Titan, Aécio Lira, Tatiana S. Pelaes, Maria Lúcia C. Correa-Giannella, Márcia Nery, Márcia Queiroz
    Clinical Therapeutics.2019; 41(10): 2008.     CrossRef
  • Efficacy and Safety of Degludec Compared to Glargine 300 Units/mL in Insulin-Experienced Patients With Type 2 Diabetes: Trial Protocol Amendment (NCT03078478)
    Athena Philis-Tsimikas, Irene Stratton, Lone Nørgård Troelsen, Britta Anker Bak, Lawrence A. Leiter
    Journal of Diabetes Science and Technology.2019; 13(3): 498.     CrossRef
  • Efficacy and safety of insulin glargine/lixisenatide (iGlarLixi) fixed-ratio combination in older adults with type 2 diabetes
    Yehuda Handelsman, Christina Chovanes, Terry Dex, Francesco Giorgino, Neil Skolnik, Elisabeth Souhami, William Stager, Elisabeth Niemoeller, Juan Pablo Frias
    Journal of Diabetes and its Complications.2019; 33(3): 236.     CrossRef
  • Urinary glucose excretion after dapagliflozin treatment: An exposure‐response modelling comparison between Japanese and non‐Japanese patients diagnosed with type 1 diabetes mellitus
    Victor Sokolov, Tatiana Yakovleva, Shinya Ueda, Joanna Parkinson, David W. Boulton, Robert C. Penland, Weifeng Tang
    Diabetes, Obesity and Metabolism.2019; 21(4): 829.     CrossRef
  • Effects on clinical outcomes of intensifying triple oral antidiabetic drug (OAD) therapy by initiating insulin versus enhancing OAD therapy in patients with type 2 diabetes: A nationwide population‐based, propensity‐score‐matched cohort study
    Shihchen Kuo, Chun‐Ting Yang, Jin‐Shang Wu, Huang‐Tz Ou
    Diabetes, Obesity and Metabolism.2019; 21(2): 312.     CrossRef
  • Cardiovascular safety and lower severe hypoglycaemia of insulin degludec versus insulin glargine U100 in patients with type 2 diabetes aged 65 years or older: Results from DEVOTE (DEVOTE 7)
    Richard E. Pratley, Scott S. Emerson, Edward Franek, Matthew P. Gilbert, Steven P. Marso, Darren K. McGuire, Thomas R. Pieber, Bernard Zinman, Charlotte T. Hansen, Melissa V. Hansen, Thomas Mark, Alan C. Moses, John B. Buse
    Diabetes, Obesity and Metabolism.2019; 21(7): 1625.     CrossRef
  • Review of the cardiovascular safety of dipeptidyl peptidase-4 inhibitors and the clinical relevance of the CAROLINA trial
    Marile Santamarina, Curt J. Carlson
    BMC Cardiovascular Disorders.2019;[Epub]     CrossRef
  • Effects of a 12-week moderate-intensity exercise training on blood glucose response in patients with type 2 diabetes
    Shang-Lin Chiang, Margaret McLean Heitkemper, Yi-Jen Hung, Wen-Chii Tzeng, Meei-Shyuan Lee, Chia-Huei Lin
    Medicine.2019; 98(36): e16860.     CrossRef
  • Impaired Awareness of Hypoglycaemia in Insulin-treated Type 2 Diabetes Mellitus
    Mohammad J. Alkhatatbeh, Nedaa A. Abdalqader , Mohammad A.Y. Alqudah
    Current Diabetes Reviews.2019; 15(5): 407.     CrossRef
  • Hypoglycaemia, cardiovascular disease, and mortality in diabetes: epidemiology, pathogenesis, and management
    Stephanie A Amiel, Pablo Aschner, Belinda Childs, Philip E Cryer, Bastiaan E de Galan, Brian M Frier, Linda Gonder-Frederick, Simon R Heller, Timothy Jones, Kamlesh Khunti, Lawrence A Leiter, Yingying Luo, Rory J McCrimmon, Ulrik Pedersen-Bjergaard, Eliza
    The Lancet Diabetes & Endocrinology.2019; 7(5): 385.     CrossRef
  • Sulfonylureas as initial treatment for type 2 diabetes and the risk of adverse cardiovascular events: A population‐based cohort study
    Kristian B. Filion, Antonios Douros, Laurent Azoulay, Hui Yin, Oriana H. Yu, Samy Suissa
    British Journal of Clinical Pharmacology.2019; 85(10): 2378.     CrossRef
  • Selectivity of beta-blockers, cardiovascular and all-cause mortality in people with hypoglycaemia: An observational study
    F. Zaccardi, L.L. Nystrup Husemoen, B.L. Thorsted, D.R. Webb, S.K. Paul, M.J. Davies, K. Khunti
    Nutrition, Metabolism and Cardiovascular Diseases.2019; 29(5): 481.     CrossRef
  • Cost-effectiveness of a primary care multidisciplinary Risk Assessment and Management Program for patients with diabetes mellitus (RAMP-DM) over lifetime
    Fangfang Jiao, Eric Yuk Fai Wan, Colman Siu Cheung Fung, Anca Ka Chun Chan, Sarah Morag McGhee, Ruby Lai Ping Kwok, Cindy Lo Kuen Lam
    Endocrine.2019; 63(2): 259.     CrossRef
  • Efficacy and safety of sensor-augmented pump therapy (SAPT) with predictive low-glucose management in patients diagnosed with type 1 diabetes mellitus previously treated with SAPT and low glucose suspend
    Ana María Gómez, Diana Cristina Henao, Angelica Imitola, Oscar Mauricio Muñoz, Martín Alonso Rondón Sepúlveda, Laura Kattah, Juan Sebastian Guerrero, Elly Morros, Juan Pablo Llano, Maira García Jaramillo, Fabián León-Vargas
    Endocrinología, Diabetes y Nutrición.2018; 65(8): 451.     CrossRef
  • Recent diabetes-related mortality trends in Romania
    Sorin Ioacara, Elisabeta Sava, Olivia Georgescu, Anca Sirbu, Simona Fica
    Acta Diabetologica.2018; 55(8): 821.     CrossRef
  • Use of sodium-glucose co-transporter-2 inhibitors from clinical trial results to practical application in Russia
    D. A. Lebedev, A. Yu. Babenko
    Medical Council.2018; (16): 100.     CrossRef
  • Severe hypoglycemia is a risk factor for atrial fibrillation in type 2 diabetes mellitus: Nationwide population-based cohort study
    Seung-Hyun Ko, Yong-Moon Park, Jae-Seung Yun, Seon-Ah Cha, Eue-Keun Choi, Kyungdo Han, Eugene Han, Yong-ho Lee, Yu-Bae Ahn
    Journal of Diabetes and its Complications.2018; 32(2): 157.     CrossRef
  • Antioxidant effects of epigallocatechin-3-gallate on the aTC1-6 pancreatic alpha cell line
    Ting Cao, Xiong Zhang, Dan Yang, Yue-Qian Wang, Zheng-Dong Qiao, Jian-Ming Huang, Peng Zhang
    Biochemical and Biophysical Research Communications.2018; 495(1): 693.     CrossRef
  • Hemoglobin glycation index predicts cardiovascular disease in people with type 2 diabetes mellitus: A 10-year longitudinal cohort study
    Mee Kyoung Kim, Jee Sun Jeong, Jae-Seung Yun, Hyuk-Sang Kwon, Ki Hyun Baek, Ki-Ho Song, Yu-Bae Ahn, Seung-Hyun Ko
    Journal of Diabetes and its Complications.2018; 32(10): 906.     CrossRef
  • Day-to-day fasting glycaemic variability in DEVOTE: associations with severe hypoglycaemia and cardiovascular outcomes (DEVOTE 2)
    Bernard Zinman, Steven P. Marso, Neil R. Poulter, Scott S. Emerson, Thomas R. Pieber, Richard E. Pratley, Martin Lange, Kirstine Brown-Frandsen, Alan Moses, Ann Marie Ocampo Francisco, Jesper Barner Lekdorf, Kajsa Kvist, John B. Buse
    Diabetologia.2018; 61(1): 48.     CrossRef
  • Efficacy and safety of sensor-augmented pump therapy (SAPT) with predictive low-glucose management in patients diagnosed with type 1 diabetes mellitus previously treated with SAPT and low glucose suspend
    Ana María Gómez, Diana Cristina Henao, Angelica Imitola, Oscar Mauricio Muñoz, Martín Alonso Rondón Sepúlveda, Laura Kattah, Juan Sebastian Guerrero, Elly Morros, Juan Pablo Llano, Maira García Jaramillo, Fabián León-Vargas
    Endocrinología, Diabetes y Nutrición (English ed.).2018; 65(8): 451.     CrossRef
  • Time- and frequency-domain measures of heart rate variability predict cardiovascular outcome in patients with type 2 diabetes
    Seon-Ah Cha, Yong-Moon Park, Jae-Seung Yun, Seung-Hwan Lee, Yu-Bae Ahn, Sung-Rae Kim, Seung-Hyun Ko
    Diabetes Research and Clinical Practice.2018; 143: 159.     CrossRef
  • Newly diagnosed type 2 diabetes in an ethnic minority population: clinical presentation and comparison to other populations
    Michael Morkos, Bettina Tahsin, Louis Fogg, Leon Fogelfeld
    BMJ Open Diabetes Research & Care.2018; 6(1): e000568.     CrossRef
  • DEVOTE 3: temporal relationships between severe hypoglycaemia, cardiovascular outcomes and mortality
    Thomas R. Pieber, Steven P. Marso, Darren K. McGuire, Bernard Zinman, Neil R. Poulter, Scott S. Emerson, Richard E. Pratley, Vincent Woo, Simon Heller, Martin Lange, Kirstine Brown-Frandsen, Alan Moses, Jesper Barner Lekdorf, Lucine Lehmann, Kajsa Kvist,
    Diabetologia.2018; 61(1): 58.     CrossRef
  • Intervention effects of Compound Houttuyniae Herba to diabetic renal damage based on SOCS-JAK/STAT negative feedback regulation
    Yun Fang, Sai-cong Shao, Hai-ying Wang
    Chinese Herbal Medicines.2018; 10(4): 424.     CrossRef
  • Monotherapy in Patients with Type 2 Diabetes Mellitus
    Sang Youl Rhee, Hyun Jin Kim, Seung-Hyun Ko, Kyu-Yeon Hur, Nan-Hee Kim, Min Kyong Moon, Seok-O Park, Byung-Wan Lee, Kyung Mook Choi, Jin Hwa Kim
    Diabetes & Metabolism Journal.2017; 41(5): 349.     CrossRef
  • Monotherapy in patients with type 2 diabetes mellitus
    Sang Youl Rhee, Hyun Jin Kim, Seung-Hyun Ko, Kyu Yeon Hur, Nan-Hee Kim, Min Kyong Moon, Seok-O Park, Byung-Wan Lee, Kyung Mook Choi, Jin Hwa Kim
    The Korean Journal of Internal Medicine.2017; 32(6): 959.     CrossRef
  • Antihyperglycemic agent therapy for adult patients with type 2 diabetes mellitus 2017: a position statement of the Korean Diabetes Association
    Seung-Hyun Ko, Kyu-Yeon Hur, Sang Youl Rhee, Nan-Hee Kim, Min Kyong Moon, Seok-O Park, Byung-Wan Lee, Hyun Jin Kim, Kyung Mook Choi, Jin Hwa Kim
    The Korean Journal of Internal Medicine.2017; 32(6): 947.     CrossRef
  • Cardiovascular effects of dipeptidyl peptidase-4 inhibitor in diabetic patients with and without established cardiovascular disease: a meta-analysis and systematic review
    Shishi Xu, Xinyue Zhang, Lizhi Tang, Fang Zhang, Nanwei Tong
    Postgraduate Medicine.2017; 129(2): 205.     CrossRef
  • Antihyperglycemic Agent Therapy for Adult Patients with Type 2 Diabetes Mellitus 2017: A Position Statement of the Korean Diabetes Association
    Seung-Hyun Ko, Kyu-Yeon Hur, Sang Youl Rhee, Nan-Hee Kim, Min Kyong Moon, Seok-O Park, Byung-Wan Lee, Hyun Jin Kim, Kyung Mook Choi, Jin Hwa Kim
    Diabetes & Metabolism Journal.2017; 41(5): 337.     CrossRef
  • Effects of propofol on myocardial ischemia-reperfusion injury in rats with type-2 diabetes mellitus
    Ying Wang, Xiuru Qi, Chunliang Wang, Danning Zhao, Hongjie Wang, Jianxin Zhang
    Biomedical Reports.2017; 6(1): 69.     CrossRef
  • Cardiovascular risk assessment in patients with diabetes
    Marcello Casaccia Bertoluci, Viviane Zorzanelli Rocha
    Diabetology & Metabolic Syndrome.2017;[Epub]     CrossRef
  • Pathogenetic features of the combined course of arterial hypertension and diabetes mellitus 2 type
    O.M. Bilovol, L.R. Bobronnikova, O.V. Al-Trawneh
    Shidnoevropejskij zurnal vnutrisnoi ta simejnoi medicini.2017; 2017(1): 4.     CrossRef
  • Risk Factors and Adverse Outcomes of Severe Hypoglycemia in Type 2 Diabetes Mellitus
    Jae-Seung Yun, Seung-Hyun Ko
    Diabetes & Metabolism Journal.2016; 40(6): 423.     CrossRef
  • Real-world evidence for the safety of ipragliflozin in elderly Japanese patients with type 2 diabetes mellitus (STELLA-ELDER): final results of a post-marketing surveillance study
    Koutaro Yokote, Yasuo Terauchi, Ichiro Nakamura, Haruko Sugamori
    Expert Opinion on Pharmacotherapy.2016; 17(15): 1995.     CrossRef
  • Hypoglycemia: Culprit or Bystander?
    You-Cheol Hwang
    Diabetes & Metabolism Journal.2016; 40(3): 190.     CrossRef
  • Schwere Hypoglykämien erhöhen die Mortalität
    E. Fritschka
    MMW - Fortschritte der Medizin.2016; 158(S3): 46.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal