- Clinical Complications
- Incidence and Risk Factors for Dementia in Type 2 Diabetes Mellitus: A Nationwide Population-Based Study in Korea
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Ji Hee Yu, Kyungdo Han, Sanghyun Park, Hanna Cho, Da Young Lee, Jin-Wook Kim, Ji A Seo, Sin Gon Kim, Sei Hyun Baik, Yong Gyu Park, Kyung Mook Choi, Seon Mee Kim, Nan Hee Kim
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Diabetes Metab J. 2020;44(1):113-124. Published online November 12, 2019
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DOI: https://doi.org/10.4093/dmj.2018.0216
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Abstract
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- Background
Diabetes mellitus is associated with an increased risk of dementia. We aimed to comprehensively analyze the incidence and risk factors for dementia and young-onset dementia (YOD) in diabetic patients in Korea using the National Health Insurance Service data. MethodsBetween January 1, 2009 and December 31, 2012, a total of 1,917,702 participants with diabetes were included and followed until the date of dementia diagnosis or until December 31, 2015. We evaluated the incidence and risk factors for all dementia, Alzheimer's disease (AD), and vascular dementia (VaD) by Cox proportional hazards analyses. We also compared the impact of risk factors on the occurrence of YOD and late-onset dementia (LOD). ResultsDuring an average of 5.1 years of follow-up, the incidence of all types of dementia, AD, or VaD was 9.5, 6.8, and 1.3/1,000 person-years, respectively, in participants with diabetes. YOD comprised 4.8% of all dementia occurrence, and the ratio of AD/VaD was 2.1 for YOD compared with 5.5 for LOD. Current smokers and subjects with lower income, plasma glucose levels, body mass index (BMI), and subjects with hypertension, dyslipidemia, vascular complications, depression, and insulin treatment developed dementia more frequently. Vascular risk factors such as smoking, hypertension, and previous cardiovascular diseases were more strongly associated with the development of VaD than AD. Low BMI and a history of stroke or depression had a stronger influence on the development of YOD than LOD. ConclusionThe optimal management of modifiable risk factors may be important for preventing dementia in subjects with diabetes mellitus.
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Ho Suk Kang, Ji Hee Kim, Joo-Hee Kim, Woo Jin Bang, Hyo Geun Choi, Nan Young Kim, Ha Young Park, Mi Jung Kwon Journal of Clinical Medicine.2024; 13(1): 260. CrossRef - Hepatopancreatic metabolic disorders and their implications in the development of Alzheimer's disease and vascular dementia
Francisco I. Pinheiro, Irami Araújo-Filho, Amália C.M. do Rego, Eduardo P. de Azevedo, Ricardo N. Cobucci, Fausto P. Guzen Ageing Research Reviews.2024; 96: 102250. CrossRef - Sex Differences in the Trajectories of Cognitive Decline and Affected Cognitive Domains Among Older Adults With Controlled and Uncontrolled Glycemia
Natália Cochar-Soares, Dayane C de Oliveira, Mariane M Luiz, Márlon J R Aliberti, Claudia K Suemoto, Andrew Steptoe, Cesar de Oliveira, Tiago S Alexandre, Jay Magaziner The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences.2024;[Epub] CrossRef - SGLT2 Inhibitor Use and Risk of Dementia and Parkinson Disease Among Patients With Type 2 Diabetes
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Yu‐Hsin Yen, Fu‐Shun Yen, Fu‐Shun Ko, James Cheng‐Chung Wei, Yuhan Huang, Teng‐Shun Yu, Chii‐Min Hwu, Chih‐Cheng Hsu Diabetes, Obesity and Metabolism.2024; 26(11): 5399. CrossRef - Risk factors for the neurodegenerative dementias in the Western Pacific region
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Hee‐Cheol Kim Psychogeriatrics.2024;[Epub] CrossRef - Amygdala activity and amygdala-hippocampus connectivity: Metabolic diseases, dementia, and neuropsychiatric issues
Juhyun Song Biomedicine & Pharmacotherapy.2023; 162: 114647. CrossRef - The effects of long-term cumulative HbA1c exposure on the development and onset time of dementia in the patients with type 2 diabetes mellitus: Hospital based retrospective study (2005–2021)
Sunyoung Cho, Choon Ok Kim, Bong-soo Cha, Eosu Kim, Chung Mo Nam, Min-Gul Kim, Min Soo Park Diabetes Research and Clinical Practice.2023; 201: 110721. CrossRef - Association of triglyceride/high-density lipoprotein cholesterol ratio with severe complications of COVID-19
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Hee-Cheol Kim, Ho-Jun Lee, Yang-Tae Kim, Byeong-Churl Jang, Asirvatham Alwin Robert Journal of Diabetes Research.2023; 2023: 1. CrossRef - Sarcopenia and diabetes-induced dementia risk
Mingyang Sun, Zhongyuan Lu, Wan-Ming Chen, Szu-Yuan Wu, Jiaqiang Zhang Brain Communications.2023;[Epub] CrossRef - Association of periodontitis with microvascular complications of diabetes mellitus: A nationwide cohort study
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Yura Lee, Chi C. Cho Archives of Gerontology and Geriatrics.2021; 95: 104424. CrossRef - Cumulative Exposure to Metabolic Syndrome Components and the Risk of Dementia: A Nationwide Population-Based Study
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Dihe Cheng, Xue Zhao, Shuo Yang, Guixia Wang, Guang Ning Frontiers in Aging Neuroscience.2021;[Epub] CrossRef - Improving Cognition with Nutraceuticals Targeting TGF-β1 Signaling
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Yun Kyung Cho, Jiwoo Lee, Hwi Seung Kim, Joong-Yeol Park, Woo Je Lee, Ye-Jee Kim, Chang Hee Jung Aging.2021; 13(13): 16974. CrossRef - Letter: Hypoglycemia and Dementia Risk in Older Patients with Type 2 Diabetes Mellitus: A Propensity-Score Matched Analysis of a Population-Based Cohort Study (Diabetes Metab J 2020;44:125–33)
Jin Hwa Kim Diabetes & Metabolism Journal.2020; 44(2): 356. CrossRef - The Interplay between Diabetes and Alzheimer’s Disease—In the Hunt for Biomarkers
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