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Seok Won Park  (Park SW) 7 Articles
Complications
Higher Prevalence and Progression Rate of Chronic Kidney Disease in Elderly Patients with Type 2 Diabetes Mellitus
Kyung-Soo Kim, Seok Won Park, Yong-Wook Cho, Soo-Kyung Kim
Diabetes Metab J. 2018;42(3):224-232.   Published online May 31, 2018
DOI: https://doi.org/10.4093/dmj.2017.0065
  • 5,377 View
  • 74 Download
  • 32 Web of Science
  • 33 Crossref
AbstractAbstract PDFPubReader   
Background

To evaluate the prevalence of chronic kidney disease (CKD) and progression rate to CKD in elderly patients with type 2 diabetes mellitus (T2DM).

Methods

We investigated the medical records of 190 elderly patients (65 years or older) with T2DM from 2005 to 2011 in 6-month increments. Mean follow-up duration was 64.5 months. CKD was defined as estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2 and/or the presence of albuminuria.

Results

The mean age was 70.4 years and mean diabetes duration was 10.6 years. Among all the participants, 113 patients (59.5%) had CKD. The eGFR was significantly decreased between baseline (65.7±15.0 mL/min/1.73 m2) and the end of follow-up (52.7±17.5 mL/min/1.73 m2, P<0.001). At the end of follow-up, the prevalence of eGFR <60 mL/min/1.73 m2 had increased by 61.6% (at baseline, 44.2%). Furthermore, in patients with eGFR ≥60 mL/min/1.73 m2, the progression rate to more than CKD stage 3 was 39.6% at the end of follow-up; 30.2% of elderly diabetic patients had progressed to albuminuria from normoalbuminuria. Kaplan-Meier analysis showed that the time interval to worsening nephropathy was significantly shorter in elderly patients with diabetes duration ≥10 years than in those with diabetes duration <5 years (P=0.018).

Conclusion

CKD was commonly observed in older patients with T2DM, and the progression rate to CKD is also high. Consequently, it is important to identify and manage CKD as early as possible in elderly patients with T2DM, especially in those with diabetes duration ≥10 years.

Citations

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  • Assessing heatwave effects on disabled persons in South Korea
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  • Combination of Risks of BMI and Health-Related Lifestyles on Kidney Function in the Prediabetic Japanese Population: A Prospective Cohort Study
    Jou-Yin Chen, Shiqi Deng, Yukiko Wagatsuma
    International Journal of Environmental Research and Public Health.2023; 20(7): 5338.     CrossRef
  • Hormonal imbalance in patients with chronic renal failure in the pre-dialysis and dialysis periods (part1)
    I.P. Katerenchuk, S.T. Rustamyan, V.V. Talash, T.I. Yarmola
    INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine).2023; 19(1): 65.     CrossRef
  • The Beneficial Effect of Glycemic Control against Adverse Outcomes in Patients with Type 2 Diabetes Mellitus and Chronic Kidney Disease
    Dong-Hwa Lee
    Diabetes & Metabolism Journal.2023; 47(4): 484.     CrossRef
  • Association Between Continuous Glucose Monitoring-Derived Glycemia Risk Index and Albuminuria in Type 2 Diabetes
    Jee Hee Yoo, Ji Yoon Kim, Jae Hyeon Kim
    Diabetes Technology & Therapeutics.2023; 25(10): 726.     CrossRef
  • Global burden and influencing factors of chronic kidney disease due to type 2 diabetes in adults aged 20–59 years, 1990–2019
    Dandan Xie, Tianpeng Ma, Haoliang Cui, Jing Li, Aihua Zhang, Zhifeng Sheng, Yiqiang Xie
    Scientific Reports.2023;[Epub]     CrossRef
  • Effectiveness of Early Advanced Glycation End Product Accumulation Testing in the Diagnosis of Diabetes: A Health Risk Factor Analysis Using the Body Mass Index as a Moderator
    Yi Zhang, Tian Jiang, Chao Liu, Honglin Hu, Fang Dai, Li Xia, Qiu Zhang
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Causal association pathways between fetuin-A and kidney function: a mediation analysis
    Philip Etabee Bassey, Pawin Numthavaj, Sasivimol Rattanasiri, Piyamitr Sritara, Mark McEvoy, Boonsong Ongphiphadhanakul, Ammarin Thakkinstian
    Journal of International Medical Research.2022; 50(4): 030006052210828.     CrossRef
  • Advanced glycation end products and diabetes and other metabolic indicators
    Tian Jiang, Yi Zhang, Fang Dai, Chao Liu, Honglin Hu, Qiu Zhang
    Diabetology & Metabolic Syndrome.2022;[Epub]     CrossRef
  • Type 2 diabetes management in people aged over seventy-five years: targets and treatment strategies
    Theocharis Koufakis, Maria Grammatiki, Kalliopi Kotsa
    Maturitas.2021; 143: 118.     CrossRef
  • Comparative Efficacy of Lobeglitazone Versus Pioglitazone on Albuminuria in Patients with Type 2 Diabetes Mellitus
    Kyung-Soo Kim, Sangmo Hong, Hong-Yup Ahn, Cheol-Young Park
    Diabetes Therapy.2021; 12(1): 171.     CrossRef
  • Chronic kidney disease progression in aged patients
    Murat Tuğcu, Dilek Barutçu Ataş
    International Urology and Nephrology.2021; 53(12): 2619.     CrossRef
  • Factors determining the clinical significance of dipeptidyl peptidase-4 inhibitors in the treatment of elderly patients with type 2 diabetes mellitus
    I. V. Glinkina, A. V. Balashova, A. S. Shyman, A. V. Oderij, S. A. Khan, G. E. Runova, T. B. Morgunova, V. V. Fadeev
    Meditsinskiy sovet = Medical Council.2021; (7): 56.     CrossRef
  • Effect of Oral carnosine supplementation on urinary TGF-β in diabetic nephropathy: a randomized controlled trial
    Narongrit Siriwattanasit, Bancha Satirapoj, Ouppatham Supasyndh
    BMC Nephrology.2021;[Epub]     CrossRef
  • Estimation of the prevalence of type 2 diabetes in combination with diabetic kidney disease and identification of the associated factors in patients attending primary hospitals in Anhui Province, China
    Li Xia, Lanlan Cheng, Tian Jiang, Chao Liu, Shiqi Zhang, Honglin Hu, Fang Dai, Qiu Zhang, Yunxia Lu
    Journal of International Medical Research.2021; 49(10): 030006052110512.     CrossRef
  • A STUDY TO EVALUATE THE EFFECT OF ANAEMIA IN TYPE-2 DIABETIC PATIENTS
    Radhika Maheshwari, Divya J., J. Sahayaraj, Muthukrishnan R.
    GLOBAL JOURNAL FOR RESEARCH ANALYSIS.2021; : 117.     CrossRef
  • Metformin treatment for patients with diabetes and chronic kidney disease: A Korean Diabetes Association and Korean Society of Nephrology consensus statement
    Kyu Yeon Hur, Mee Kyoung Kim, Seung Hyun Ko, Miyeun Han, Dong Won Lee, Hyuk-Sang Kwon
    Kidney Research and Clinical Practice.2020; 39(1): 32.     CrossRef
  • Metformin Treatment for Patients with Diabetes and Chronic Kidney Disease: A Korean Diabetes Association and Korean Society of Nephrology Consensus Statement
    Kyu Yeon Hur, Mee Kyoung Kim, Seung Hyun Ko, Miyeun Han, Dong Won Lee, Hyuk-Sang Kwon
    Diabetes & Metabolism Journal.2020; 44(1): 3.     CrossRef
  • The prevalence of diabetic chronic kidney disease in adult Greek subjects with type 2 diabetes mellitus: A series from hospital-based diabetes clinics
    Ilias N. Migdalis, Nikolaos Papanas, Athanasios E. Raptis, Ioannis M. Ioannidis, Alexios E. Sotiropoulos, George D. Dimitriadis
    Diabetes Research and Clinical Practice.2020; 166: 108243.     CrossRef
  • Proteinuria Is Associated with Carotid Artery Atherosclerosis in Non-Albuminuric Type 2 Diabetes: A Cross-Sectional Study
    Jaehyun Bae, Yong-ho Lee, Eun Seok Kang, Bong-Soo Cha, Byung-Wan Lee
    Journal of Clinical Medicine.2020; 9(1): 136.     CrossRef
  • Renal status in elderly patients with type 2 diabetes
    Kazunaga Takamatsu
    Clinical and Experimental Nephrology.2020; 24(1): 53.     CrossRef
  • The fat mass, estimated glomerular filtration rate, and chronic inflammation in type 2 diabetic patients
    Tomáš Šálek, Alena Adamíková, Petr Ponížil
    Journal of Clinical Laboratory Analysis.2020;[Epub]     CrossRef
  • Insulin: Trigger and Target of Renal Functions
    Ana F. Pina, Diego O. Borges, Maria João Meneses, Patrícia Branco, Rita Birne, Antonio Vilasi, Maria Paula Macedo
    Frontiers in Cell and Developmental Biology.2020;[Epub]     CrossRef
  • Rate of kidney function decline and factors predicting progression of kidney disease in type 2 diabetes mellitus patients with reduced kidney function: A nationwide retrospective cohort study
    Wisit Kaewput, Charat Thongprayoon, Api Chewcharat, Ram Rangsin, Bancha Satirapoj, Chalermrat Kaewput, Picha Suwannahitatorn, Tarun Bathini, Michael A. Mao, Liam D. Cato, Andrew M. Harrison, Pradeep Vaitla, Wisit Cheungpasitporn
    Therapeutic Apheresis and Dialysis.2020; 24(6): 677.     CrossRef
  • Association Between Continuous Glucose Monitoring-Derived Time in Range, Other Core Metrics, and Albuminuria in Type 2 Diabetes
    Jee Hee Yoo, Min Sun Choi, Jiyeon Ahn, Sung Woon Park, Yejin Kim, Kyu Yeon Hur, Sang-Man Jin, Gyuri Kim, Jae Hyeon Kim
    Diabetes Technology & Therapeutics.2020; 22(10): 768.     CrossRef
  • Comparison of Renal Effects of Ezetimibe–Statin Combination versus Statin Monotherapy: A Propensity-Score-Matched Analysis
    Jaehyun Bae, Namki Hong, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Yong-ho Lee
    Journal of Clinical Medicine.2020; 9(3): 798.     CrossRef
  • Metformin Use and Risk of All-Cause Mortality and Cardiovascular Events in Patients With Chronic Kidney Disease—A Systematic Review and Meta-Analysis
    Yao Hu, Min Lei, Guibao Ke, Xin Huang, Xuan Peng, Lihui Zhong, Ping Fu
    Frontiers in Endocrinology.2020;[Epub]     CrossRef
  • Treatment with Cinacalcet in Hemodialysis Patients with Severe Secondary Hyperparathyroidism, Influences Bone Mineral Metabolism and Anemia Parameters
    Maria Aktsiali, Theodora Papachrysanthou , Ioannis Griveas, Christos Andriopoulos, Panagiotis Sitaras, Ioannis K. Triantafyllopoulos , George I. Lambrou
    Current Drug Therapy.2020; 15(3): 249.     CrossRef
  • Gemigliptin Attenuates Renal Fibrosis Through Down-Regulation of the NLRP3 Inflammasome
    Jung Beom Seo, Yeon-Kyung Choi, Hye-In Woo, Yun-A Jung, Sungwoo Lee, Seunghyeong Lee, Mihyang Park, In-Kyu Lee, Gwon-Soo Jung, Keun-Gyu Park
    Diabetes & Metabolism Journal.2019; 43(6): 830.     CrossRef
  • Glucometabolic characteristics and higher vascular complication risk in Korean patients with type 2 diabetes with non-albumin proteinuria
    Yongin Cho, Yong-ho Lee, Eun Seok Kang, Bong-soo Cha, Byung-wan Lee
    Journal of Diabetes and its Complications.2019; 33(8): 585.     CrossRef
  • Assessment of kidney function and associated risk factors among type 2 diabetic patients
    Moyad Jamal Shahwan, Nageeb Abdul galil Hassan, Rima Ahd Shaheen
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2019; 13(4): 2661.     CrossRef
  • Influence of diabetes mellitus on patients with lumbar spinal stenosis: A nationwide population-based study
    Chang Kyu Lee, Sun Kyu Choi, Dong Ah Shin, Seong Yi, Yoon Ha, Keung Nyun Kim, Insoo Kim, Gregory W.J. Hawryluk
    PLOS ONE.2019; 14(3): e0213858.     CrossRef
  • Predictores de progresión de enfermedad renal en el paciente anciano
    Manuel Heras Benito, Mª José Fernández Reyes Luis
    Enfermería Nefrológica.2019; 22(1): 19.     CrossRef
Complications
Color Doppler Ultrasonography Is a Useful Tool for Diagnosis of Peripheral Artery Disease in Type 2 Diabetes Mellitus Patients with Ankle-Brachial Index 0.91 to 1.40
Kyu Yeon Hur, Ji Eun Jun, Young Ju Choi, Yong-ho Lee, Dae Jung Kim, Seok Won Park, Byung Wook Huh, Eun Jig Lee, Sun-Ha Jee, Kap Bum Huh, Sung Hee Choi
Diabetes Metab J. 2018;42(1):63-73.   Published online February 23, 2018
DOI: https://doi.org/10.4093/dmj.2018.42.1.63
  • 5,882 View
  • 64 Download
  • 22 Web of Science
  • 24 Crossref
AbstractAbstract PDFPubReader   
Background

The clinical utility of ankle-brachial index (ABI) is not clear in subjects with less severe or calcified vessel. Therefore, we investigated the usefulness of color Doppler ultrasonography for diagnosing peripheral artery disease (PAD) in type 2 diabetes mellitus (T2DM) subjects.

Methods

We analyzed 324 T2DM patients who concurrently underwent ABI and carotid intima-media thickness (CIMT) measurements and color Doppler ultrasonography from 2003 to 2006. The degree of stenosis in patients with PAD was determined according to Jager's criteria, and PAD was defined as grade III (50% to 99% stenosis) or IV stenosis (100% stenosis) by color Doppler ultrasonography. Logistic regression analysis and receiver operating characteristic curve analysis were performed to evaluate the risk factors for PAD in patients with ABI 0.91 to 1.40.

Results

Among the 324 patients, 77 (23.8%) had ABI 0.91 to 1.40 but were diagnosed with PAD. Color Doppler ultrasonography demonstrated that suprapopliteal arterial stenosis, bilateral lesions, and multivessel involvement were less common in PAD patients with ABI 0.91 to 1.40 than in those with ABI ≤0.90. A multivariate logistic regression analysis demonstrated that older age, current smoking status, presence of leg symptoms, and high CIMT were significantly associated with the presence of PAD in patients with ABI 0.91 to 1.40 after adjusting for conventional risk factors. CIMT showed significant power in predicting the presence of PAD in patients with ABI 0.91 to 1.40.

Conclusion

Color Doppler ultrasonography is a useful tool for the detection of PAD in T2DM patients with ABI 0.91 to 1.40 but a high CIMT.

Citations

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  • Effectiveness of bedside investigations to diagnose peripheral artery disease among people with diabetes mellitus: A systematic review
    Vivienne Chuter, Nicolaas Schaper, Joseph Mills, Robert Hinchliffe, David Russell, Nobuyoshi Azuma, Christian‐Alexander Behrendt, Edward J. Boyko, Michael S. Conte, Misty Humphries, Lee Kirksey, Katharine C. McGinigle, Sigrid Nikol, Joakim Nordanstig, Vin
    Diabetes/Metabolism Research and Reviews.2024;[Epub]     CrossRef
  • The intersocietal IWGDF, ESVS, SVS guidelines on peripheral artery disease in people with diabetes and a foot ulcer
    Robert Fitridge, Vivienne Chuter, Joseph Mills, Robert Hinchliffe, Nobuyoshi Azuma, Christian‐Alexander Behrendt, Edward J. Boyko, Michael S. Conte, Misty Humphries, Lee Kirksey, Katharine C. McGinigle, Sigrid Nikol, Joakim Nordanstig, Vincent Rowe, David
    Diabetes/Metabolism Research and Reviews.2024;[Epub]     CrossRef
  • Diabetic Foot Complications in Saudi Arabia: A Retrospective Study
    Sherif M Zaki, Dina S El Karsh, Tuleen M Faden, Leen T Almghamsi, Joud O Fathaldin, Omar A Alhazmi
    Cureus.2024;[Epub]     CrossRef
  • Role of Color Doppler Ultrasound to Evaluate the Lower Limb Deep Venous Thrombosis in Diabetic Patients
    Muhammad Ahmad Raza, Abdul Rauf, Bushra Akmal Khan, Muhammad Asad Alam, Laamia Altuf, Aftab Alloudin, Saman Fatima
    Pakistan Journal of Health Sciences.2024; : 03.     CrossRef
  • Risk factors of peripheral occlusive arterial disease in patients with diabetic retinopathy due to type 2 diabetes
    Milos Maksimovic
    Srpski arhiv za celokupno lekarstvo.2024; 152(1-2): 50.     CrossRef
  • Comparison of Color Doppler Ultrasound and Ankle-Brachial Pressure Index Measurement in Peripheral Vascular Diseases
    Shradha Gupta, Amit Mahajan, Anil Luther, Shubhra Rathore
    Indian Journal of Surgery.2023; 85(S1): 177.     CrossRef
  • Are portable ankle brachial pressure index measurement devices suitable for hypertension screening?
    Justyna Janus, Jennifer K. Nicholls, Edward Pallett, Matthew Bown, Emma M. L. Chung, Mohamed Yacin Sikkandar
    PLOS ONE.2023; 18(3): e0283281.     CrossRef
  • Clinical characteristics and risk factors of lower extremity amputation in the diabetic inpatients with foot ulcers
    Hongping Gong, Yan Ren, Zhenyi Li, Panpan Zha, Raju Bista, Yan Li, Dawei Chen, Yun Gao, Lihong Chen, Xingwu Ran, Chun Wang
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Diabetes mellitus and long-time outcomes of autovenous femoro-popliteal bypass
    A. S. Artemova, M. A. Chernyavskiy
    Diabetes mellitus.2023; 26(2): 182.     CrossRef
  • Association between carotid ultrasonographic parameters and microvascular and macrovascular complications in diabetes: A systematic review and meta-analysis
    Meimei Liao, Sen Chen, Ruiqiang Guo
    Journal of Diabetes and its Complications.2023; 37(8): 108554.     CrossRef
  • The intersocietal IWGDF, ESVS, SVS guidelines on peripheral artery disease in people with diabetes mellitus and a foot ulcer
    Robert Fitridge, Vivienne Chuter, Joseph Mills, Robert Hinchliffe, Nobuyoshi Azuma, Christian-Alexander Behrendt, Edward J. Boyko, Michael S. Conte, Misty Humphries, Lee Kirksey, Katharine C. McGinigle, Sigrid Nikol, Joakim Nordanstig, Vincent Rowe, David
    Journal of Vascular Surgery.2023; 78(5): 1101.     CrossRef
  • Editor's Choice – The Intersocietal IWGDF, ESVS, SVS Guidelines on Peripheral Artery Disease in People With Diabetes Mellitus and a Foot Ulcer
    Robert Fitridge, Vivienne Chuter, Joseph Mills, Robert Hinchliffe, Nobuyoshi Azuma, Christian-Alexander Behrendt, Edward J. Boyko, Michael S. Conte, Misty Humphries, Lee Kirksey, Katharine C. McGinigle, Sigrid Nikol, Joakim Nordanstig, Vincent Rowe, David
    European Journal of Vascular and Endovascular Surgery.2023; 66(4): 454.     CrossRef
  • Peripheral Artery Disease: A Comprehensive Updated Review
    Garba Rimamskep Shamaki, Favour Markson, Demilade Soji-Ayoade, Chibuike Charles Agwuegbo, Michael Olaseni Bamgbose, Bob-Manuel Tamunoinemi
    Current Problems in Cardiology.2022; 47(11): 101082.     CrossRef
  • Reliability of bedside tests for diagnosing peripheral arterial disease in patients prone to medial arterial calcification: A systematic review
    Jeroen J.W.M. Brouwers, Siem A. Willems, Lauren N. Goncalves, Jaap F. Hamming, Abbey Schepers
    eClinicalMedicine.2022; 50: 101532.     CrossRef
  • Comparative Doppler ultrasound findings of foot arteries in patients with type 2 diabetes mellitus and normoglycaemic patients
    LatifatTunrayo Oduola-Owoo, AdekunleAyokunle Adeyomoye, OmodeleAbosede Olowoyeye, IfedayoAdeola Odeniyi, BukunmiMichael Idowu, BadmusBabatunde Oduola-Owoo, AdeniyiSunday Aderibigbe
    Journal of West African College of Surgeons.2022; 12(1): 55.     CrossRef
  • Reliability of Bedside Tests for Diagnosing Peripheral Arterial Disease in Patients Prone to Medial Arterial Calcification: A Systematic Review
    Jeroen Brouwers, Siem Willems, Lauren Goncalves, Jaap Hamming, Abbey Schepers
    SSRN Electronic Journal .2022;[Epub]     CrossRef
  • Estimating the diagnostic accuracy of the ankle–brachial pressure index for detecting peripheral arterial disease in people with diabetes: A systematic review and meta‐analysis
    V. H. Chuter, A. Searle, A. Barwick, J. Golledge, L. Leigh, C. Oldmeadow, B. Peterson, P. Tehan, S. M. Twigg
    Diabetic Medicine.2021;[Epub]     CrossRef
  • Prevalence of peripheral arterial disease and associated factors in people with type 2 diabetes
    Pedro José da Silva Filho, Elaine Cristina Martinez Teodoro, Elaine Cristina Alves Pereira, Vania Cristina dos Reis Miranda
    Fisioterapia em Movimento.2021;[Epub]     CrossRef
  • Peripheral Arterial Disease and Its Associated Factors among Type 2 Diabetes Mellitus Patients at Debre Tabor General Hospital, Northwest Ethiopia
    Yonas Akalu, Ambaye Birhan
    Journal of Diabetes Research.2020; 2020: 1.     CrossRef
  • Critical analysis and limitations of resting ankle-brachial index in the diagnosis of symptomatic peripheral arterial disease patients and the role of diabetes mellitus and chronic kidney disease
    Ali F. AbuRahma, Elliot Adams, Joseph AbuRahma, Luis A. Mata, L. Scott Dean, Cristyn Caron, Jennifer Sloan
    Journal of Vascular Surgery.2020; 71(3): 937.     CrossRef
  • Association of Time in Range levels with Lower Extremity Arterial Disease in patients with type 2 diabetes
    Jinfeng Li, Ya Li, Weiguo Ma, Yishan Liu, Xiaohong Yin, Chuanqing Xie, Jiao Bai, Min Zhang
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2020; 14(6): 2081.     CrossRef
  • The accuracy of toe brachial index and ankle brachial index in the diagnosis of lower limb peripheral arterial disease: A systematic review and meta-analysis
    Ángel Herraiz-Adillo, Iván Cavero-Redondo, Celia Álvarez-Bueno, Diana P. Pozuelo-Carrascosa, Montserrat Solera-Martínez
    Atherosclerosis.2020; 315: 81.     CrossRef
  • Exercise-induced calf muscle hyperemia: quantitative mapping with low-dose dynamic contrast enhanced magnetic resonance imaging
    Jeff L. Zhang, Gwenael Layec, Christopher Hanrahan, Christopher C. Conlin, Corey Hart, Nan Hu, Lillian Khor, Michelle Mueller, Vivian S. Lee
    American Journal of Physiology-Heart and Circulatory Physiology.2019; 316(1): H201.     CrossRef
  • Comparison of different methods of ABI acquisition for detection of peripheral artery disease in diabetic patients
    Miroslav Homza, Ondrej Machaczka, Martin Porzer, Milan Kozak, Jiri Plasek, David Sipula
    Biomedical Papers.2019; 163(3): 227.     CrossRef
Plasma Glucose Regulation and Mortality in Korea: A Pooled Analysis of Three Community-Based Cohort Studies
Nan Hee Kim, Dong-Jun Kim, Seok Won Park, Jee-Young Oh, Joong-Yeol Park, Chol Shin, Hong Kyu Lee, Yongsoo Park
Diabetes Metab J. 2014;38(1):44-50.   Published online February 19, 2014
DOI: https://doi.org/10.4093/dmj.2014.38.1.44
  • 3,924 View
  • 30 Download
  • 5 Web of Science
  • 5 Crossref
AbstractAbstract PDFPubReader   
Background

Although diabetes is a well-known risk factor for death, its impact on cancer death is not clearly understood. Furthermore, it remains controversial whether impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT) are associated with increased risk of mortality. We investigated the impact of diabetes or glucose tolerance categories on all cause and cause-specific mortality.

Methods

Mortality analysis was conducted in three population-based cohort studies of 3,801 participants, divided according to fasting plasma glucose (FPG) (normal; stage 1 IFG [5.6≤FPG<6.1 mmol/L]; stage 2 IFG [6.1≤FPG<7.0 mmol/L]; diabetes mellitus [DM]-FPG); or 2-hour glucose after 75 g glucose loading (2hPG) (normal; IGT; DM-2hPG), or a combination of FPG and 2hPG criteria.

Results

During a median follow-up of 11.0 years, 474 subjects died from all causes. Hazard ratios (HRs) for all cause death were higher in those with diabetes as defined by either FPG or 2hPG criteria than their normal counterparts (HR, 2.2, 95% confidence interval [CI], 1.6 to 2.9 for DM-FPG; HR, 2.0, 95% CI, 1.5 to 2.7 for DM-2hPG). Similarly, diabetes defined by either FPG or 2hPG was associated with cancer death (HR, 2.9, 95% CI, 1.7 to 5.0; and HR, 2.1, 95% CI, 1.2 to 3.9, respectively). Although neither IFG nor IGT conferred higher risk for death, when combining stage 2 IFG and/or IGT, the risk of all cause death was higher than in subjects with normal glucose regulation (HR, 1.3; 95% CI, 1.0 to 1.6).

Conclusion

Diabetes is associated with higher risk of death from all causes and cancer. In subjects without diabetes, stage 2 IFG and/or IGT confers increased risk for mortality.

Citations

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  • Abnormal Fasting Glucose Increases Risk of Unrecognized Myocardial Infarctions in an Elderly Cohort
    Richard Brandon Stacey, Janice Zgibor, Paul E. Leaverton, Douglas D. Schocken, Jennifer A. Peregoy, Mary F. Lyles, Alain G. Bertoni, Gregory L. Burke
    Journal of the American Geriatrics Society.2019; 67(1): 43.     CrossRef
  • Increased Vascular Disease Mortality Risk in Prediabetic Korean Adults Is Mainly Attributable to Ischemic Stroke
    Nam Hoon Kim, Tae Yeon Kwon, Sungwook Yu, Nan Hee Kim, Kyung Mook Choi, Sei Hyun Baik, Yousung Park, Sin Gon Kim
    Stroke.2017; 48(4): 840.     CrossRef
  • β-Cell Function and Insulin Sensitivity in Normal Glucose-Tolerant Subjects Stratified by 1-Hour Plasma Glucose Values
    Miranda M. Priya, Anandakumar Amutha, T.A. Pramodkumar, Harish Ranjani, Saravanan Jebarani, Kuppan Gokulakrishnan, Rajendra Pradeepa, Ranjit Unnikrishnan, Ranjit Mohan Anjana, Viswanathan Mohan
    Diabetes Technology & Therapeutics.2016; 18(1): 29.     CrossRef
  • Effect of Socio-Economic Status on the Prevalence of Diabetes
    Yu Jeong Kim, Ja Young Jeon, Seung Jin Han, Hae Jin Kim, Kwan Woo Lee, Dae Jung Kim
    Yonsei Medical Journal.2015; 56(3): 641.     CrossRef
  • The Population-Based Risk of Need for Coronary Revascularization According to the Presence of Type 2 Diabetes Mellitus and History of Coronary Heart Disease in the Korean Population
    Chang Hee Jung, Gi Hyeon Seo, Sunghwan Suh, Ji Cheol Bae, Mee Kyoung Kim, You-Cheol Hwang, Jae Hyeon Kim, Byung-Wan Lee, Xian Wu Cheng
    PLOS ONE.2015; 10(6): e0128627.     CrossRef
Diabetes Epidemics in Korea: Reappraise Nationwide Survey of Diabetes "Diabetes in Korea 2007"
Ie Byung Park, Jaiyong Kim, Dae Jung Kim, Choon Hee Chung, Jee-Young Oh, Seok Won Park, Juneyoung Lee, Kyung Mook Choi, Kyung Wan Min, Jeong Hyun Park, Hyun Shik Son, Chul Woo Ahn, Hwayoung Kim, Sunhee Lee, Im Bong Lee, Injeoung Choi, Sei Hyun Baik
Diabetes Metab J. 2013;37(4):233-239.   Published online August 14, 2013
DOI: https://doi.org/10.4093/dmj.2013.37.4.233
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AbstractAbstract PDFPubReader   

There are many studies on the prevalence, clinical characteristics, and economic burden of diabetes across the past four decades in Korea. Nonetheless, there is a dearth of nationwide study regarding diabetes encompassing all age group. Eight years ago, the Committee on the Epidemiology of Diabetes Mellitus of Korean Diabetes Association collaborated with Health Insurance Review & Assessment Service to evaluate the status of diabetes care and characteristics in diabetic patients in Korea. In 2007, the collaborative task force team published a comprehensive survey titled "Diabetes in Korea 2007." In this review, we reappraise the diabetic epidemics from the joint report and suggest further studies that are needed to be investigated in the future.

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  • Revisiting the Diabetes Crisis in Korea: Call for Urgent Action
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    The Journal of Korean Diabetes.2023; 24(1): 1.     CrossRef
  • Risk assessment and classification for foot ulceration among patients with type 2 diabetes in South Korea
    Eun Joo Lee, Ihn Sook Jeong, In Ju Kim, Young Hye Cho, Yun Jin Kim
    International Journal of Nursing Practice.2022;[Epub]     CrossRef
  • Using real-world data for supporting regulatory decision making: Comparison of cardiovascular and safety outcomes of an empagliflozin randomized clinical trial versus real-world data
    Ha Young Jang, In-Wha Kim, Jung Mi Oh
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • Differences in health behavior and nutrient intake status between diabetes-aware and unaware Korean adults based on the Korea national health and nutrition examination survey 2016–18 data: A cross-sectional study
    Anshul Sharma, Chen Lulu, Kee-Ho Song, Hae-Jeung Lee
    Frontiers in Public Health.2022;[Epub]     CrossRef
  • Do statins benefit low-risk population for primary prevention of atherosclerotic cardiovascular disease: A retrospective cohort study
    In Sun Ryou, Ju Young Kim, Hwa Yeon Park, Sohee Oh, Sehun Kim, Hwa Jung Kim
    Frontiers in Medicine.2022;[Epub]     CrossRef
  • Association between oseltamivir use and neuropsychiatric adverse events in influenza patients: a nationwide population-based cohort study
    Hye-Rim Kang, Suk-Chan Jang, Ju-Young Shin
    Expert Opinion on Drug Safety.2021; 20(2): 245.     CrossRef
  • Effectiveness and safety of sodium‐glucose co‐transporter‐2 inhibitors compared with dipeptidyl peptidase‐4 inhibitors in older adults with type 2 diabetes: A nationwide population‐based study
    Seung Jin Han, Kyoung Hwa Ha, Nami Lee, Dae Jung Kim
    Diabetes, Obesity and Metabolism.2021; 23(3): 682.     CrossRef
  • Cost-Effectiveness of Tiotropium in Elderly Patients with Severe Asthma Using Real-World Data
    Sung-Hyun Hong, Jeong-Yeon Cho, Tae-Bum Kim, Eui-Kyung Lee, Sun-Hong Kwon, Ju-Young Shin
    The Journal of Allergy and Clinical Immunology: In Practice.2021; 9(5): 1939.     CrossRef
  • Dapagliflozin improves cardiovascular risk factors in Emirati patients with T2DM
    Aml Mohamed Nada, Mariam Adel Younan
    Therapeutic Advances in Endocrinology and Metabolism.2021; 12: 204201882199536.     CrossRef
  • Association between socioeconomic position and diabetic foot ulcer outcomes: a population-based cohort study in South Korea
    Jeong Hyun Ha, Heejin Jin, Ji-Ung Park
    BMC Public Health.2021;[Epub]     CrossRef
  • Etiology, diagnosis, complications, and treatments of diabetic foot
    Dong-Kyo Seo
    Journal of the Korean Medical Association.2021; 64(8): 523.     CrossRef
  • Hospital admissions due to endocrine diseases in Korean male firefighters
    Seunghoon Ryu, Yong-Jin Lee, Eun-Chul Jang, Soon-Chan Kwon, KiSeok Kim, Yeon-Soon Ahn, Young-Sun Min
    Annals of Occupational and Environmental Medicine.2021;[Epub]     CrossRef
  • Association between Frequency of Breakfast Consumption and Insulin Resistance Using Triglyceride-Glucose Index: A Cross-Sectional Study of the Korea National Health and Nutrition Examination Survey (2016–2018)
    Hye Jin Joo, Gyu Ri Kim, Eun-Cheol Park, Sung-In Jang
    International Journal of Environmental Research and Public Health.2020; 17(9): 3322.     CrossRef
  • Review of Diabetic Foot Complication Assessment Tools Developed from 2007 to 2016
    Yoonhee Lee, Youngshin Song
    Journal of Korean Academy of Fundamentals of Nursing.2019; 26(4): 231.     CrossRef
  • Associations between Breastfeeding and Type 2 Diabetes Mellitus and Glycemic Control in Parous Women: A Nationwide, Population-Based Study
    Ga Eun Nam, Kyungdo Han, Do-Hoon Kim, Youn Huh, Byoungduck Han, Sung Jung Cho, Yong Gyu Park, Yong-Moon Park
    Diabetes & Metabolism Journal.2019; 43(2): 236.     CrossRef
  • Risk of osteoporosis in patients with chronic inflammatory neuropathy- a population-based cohort study
    Seung Woo Kim, Eun Hwa Kim, Jinae Lee, Young-Chul Choi, Seung Min Kim, Ha Young Shin
    Scientific Reports.2019;[Epub]     CrossRef
  • Differences in the risk of mood disorders in patients with asthma-COPD overlap and in patients with COPD alone: a nationwide population-based retrospective cohort study in Korea
    Hye-Rim Kang, Sung-Hyun Hong, So-Young Ha, Tae-Bum Kim, Eui-Kyung Lee
    Respiratory Research.2019;[Epub]     CrossRef
  • A Comparison of Leukotriene Receptor Antagonists to Low-Dose Inhaled Corticosteroids in the Elderly with Mild Asthma
    Sung-Hyun Hong, Hye-Rim Kang, Jin Hyun Nam, Sun-Kyeong Park, Tae-Bum Kim, Eui-Kyung Lee
    The Journal of Allergy and Clinical Immunology: In Practice.2019; 7(8): 2642.     CrossRef
  • The Need to Improve the Quality of Diabetes Care in Korea
    Seung Jin Han, Dae Jung Kim
    Journal of Korean Medical Science.2019;[Epub]     CrossRef
  • Fifty Years of Compassionate Care and Harmonious Collaboration of the Korean Diabetes Association: The 50th Anniversary of Korean Diabetes Association
    Jong Chul Won, Eun-Jung Rhee, Hyung Joon Yoo
    Diabetes & Metabolism Journal.2018; 42(6): 475.     CrossRef
  • Depth and combined infection is important predictor of lower extremity amputations in hospitalized diabetic foot ulcer patients
    Eun-Gyo Jeong, Sung Shim Cho, Sang-Hoon Lee, Kang-Min Lee, Seo-Kyung Woo, Yoongoo Kang, Jae-Seung Yun, Seon-Ah Cha, Yoon-Jung Kim, Yu-Bae Ahn, Seung-Hyun Ko, Jung-Min Lee
    The Korean Journal of Internal Medicine.2018; 33(5): 952.     CrossRef
  • Favorable glycemic response after pancreatoduodenectomy in both patients with pancreatic cancer and patients with non-pancreatic cancer
    Seo Young Sohn, Eun Kyung Lee, Sung-Sik Han, You Jin Lee, Yul Hwangbo, Young Hwa Kang, Seung Duk Lee, Seong Hoon Kim, Sang Myung Woo, Woo Jin Lee, Eun Kyung Hong, Sang-Jae Park
    Medicine.2018; 97(18): e0590.     CrossRef
  • Clinical Importance of Diabetic Neuropathy
    Tae Sun Park
    The Journal of Korean Diabetes.2018; 19(3): 147.     CrossRef
  • Women are less likely than men to achieve optimal glycemic control after 1 year of treatment: A multi-level analysis of a Korean primary care cohort
    Seung-Ah Choe, Joo Yeong Kim, Young Sun Ro, Sung-Il Cho, Antonio Palazón-Bru
    PLOS ONE.2018; 13(5): e0196719.     CrossRef
  • Diagnosis and Management of Diabetic Foot
    Chang Won Lee
    The Journal of Korean Diabetes.2018; 19(3): 168.     CrossRef
  • HbA1c Cutoff for Prediabetes and Diabetes Based on Oral Glucose Tolerance Test in Obese Children and Adolescents
    Hyo-Kyoung Nam, Won Kyoung Cho, Jae Hyun Kim, Young-Jun Rhie, Sochung Chung, Kee-Hyoung Lee, Byung-Kyu Suh
    Journal of Korean Medical Science.2018;[Epub]     CrossRef
  • Diabetes Fact Sheet in Korea, 2016: An Appraisal of Current Status
    Jong Chul Won, Jae Hyuk Lee, Jae Hyeon Kim, Eun Seok Kang, Kyu Chang Won, Dae Jung Kim, Moon-Kyu Lee
    Diabetes & Metabolism Journal.2018; 42(5): 415.     CrossRef
  • Risk factors of asthma exacerbation based on asthma severity: a nationwide population-based observational study in South Korea
    Hye-Rim Kang, Hyun Jin Song, Jin Hyun Nam, Sung-Hyun Hong, So-Young Yang, SangEun Ju, Sang Won Lee, Tae-Bum Kim, Hye-Lin Kim, Eui-Kyung Lee
    BMJ Open.2018; 8(3): e020825.     CrossRef
  • Foot Care for Diabetic Patients
    Hye Jung Cha
    The Journal of Korean Diabetes.2018; 19(1): 41.     CrossRef
  • Risk of new-onset diabetes among patients treated with statins according to hypertension and gender: Results from a nationwide health-screening cohort
    Sang-Eun Lee, Ji Min Sung, In-Jeong Cho, Hyeon Chang Kim, Hyuk-Jae Chang, Lamberto Manzoli
    PLOS ONE.2018; 13(4): e0195459.     CrossRef
  • Treatment variation related to comorbidity and complications in type 2 diabetes
    Yeon Young Cho, Sung-il Cho
    Medicine.2018; 97(37): e12435.     CrossRef
  • Efficacy of Body Weight Reduction on the SGLT2 Inhibitor in People with Type 2 Diabetes Mellitus
    Hyun A Cho, Young Lee Jung, Yong Hoon Lee, Yu Chang Lee, Jung Eun Lee, Sol Jae Lee, Su Jin Jeong, Chong Hwa Kim
    Journal of Obesity & Metabolic Syndrome.2017; 26(2): 107.     CrossRef
  • Physician-Directed Diabetes Education without a Medication Change and Associated Patient Outcomes
    Hun-Sung Kim, Hyunah Kim, Hae-Kyung Yang, Eun Young Lee, Yoo Jin Jeong, Tong Min Kim, So Jung Yang, Seo Yeon Baik, Seung-Hwan Lee, Jae Hyoung Cho, In Young Choi, Hyeon Woo Yim, Bong-Yun Cha
    Diabetes & Metabolism Journal.2017; 41(3): 187.     CrossRef
  • Current status of managing diabetes mellitus in Korea
    Kyoung Hwa Ha, Dae Jung Kim
    The Korean Journal of Internal Medicine.2016; 31(5): 845.     CrossRef
  • 7th Asian PAD Workshop

    Annals of Vascular Diseases.2016; 9(2): 135.     CrossRef
  • Trends in Diabetes Incidence in the Last Decade Based on Korean National Health Insurance Claims Data
    Sun Ok Song, Yong-ho Lee, Dong Wook Kim, Young Duk Song, Joo Young Nam, Kyoung Hye Park, Dae Jung Kim, Seok Won Park, Hyun Chul Lee, Byung-Wan Lee
    Endocrinology and Metabolism.2016; 31(2): 292.     CrossRef
  • Trends of antidiabetic drug use in adult type 2 diabetes in Korea in 2002–2013
    Seung-Hyun Ko, Dae-Jung Kim, Jong-Heon Park, Cheol-Young Park, Chang Hee Jung, Hyuk-Sang Kwon, Joong-Yeol Park, Kee-Ho Song, Kyungdo Han, Ki-Up Lee, Kyung-Soo Ko
    Medicine.2016; 95(27): e4018.     CrossRef
  • Glycosylated Hemoglobin Threshold for Predicting Diabetes and Prediabetes from the Fifth Korea National Health and Nutrition Examination Survey
    Sangmo Hong, Jun Goo Kang, Chul Sik Kim, Seong Jin Lee, Cheol-Young Park, Chang Beom Lee, Sung-Hee Ihm
    Diabetes & Metabolism Journal.2016; 40(2): 167.     CrossRef
  • Predictive Value of Glucose Parameters Obtained From Oral Glucose Tolerance Tests in Identifying Individuals at High Risk for the Development of Diabetes in Korean Population
    Hae Kyung Yang, Hee-Sung Ha, Marie Rhee, Jin-Hee Lee, Yong-Moon Park, Hyuk-Sang Kwon, Hyeon-Woo Yim, Moo-Il Kang, Won-Chul Lee, Ho-Young Son, Seung-Hwan Lee, Kun-Ho Yoon
    Medicine.2016; 95(10): e3053.     CrossRef
  • Serum preadipocyte factor 1 concentrations and risk of developing diabetes: a nested case–control study
    S. H. Lee, M. Rhee, H. K. Yang, H. S. Ha, J. H. Lee, H. S. Kwon, Y. M. Park, H. W. Yim, M. I. Kang, W. C. Lee, H. Y. Son, K. H. Yoon
    Diabetic Medicine.2016; 33(5): 631.     CrossRef
  • Is an Oral Glucose Tolerance Test Still Valid for Diagnosing Diabetes Mellitus?
    Dong-Lim Kim, Sun-Doo Kim, Suk Kyeong Kim, Sooyoun Park, Kee-Ho Song
    Diabetes & Metabolism Journal.2016; 40(2): 118.     CrossRef
  • Fasting plasma glucose concentrations for specified HbA1c goals in Korean populations: data from the Fifth Korea National Health and Nutrition Examination Survey (KNHANES V-2, 2011)
    Sangmo Hong, Jun Goo Kang, Chul Sik Kim, Seong Jin Lee, Chang Beom Lee, Sung-Hee Ihm
    Diabetology & Metabolic Syndrome.2016;[Epub]     CrossRef
  • Combined use of basal insulin analog and acarbose reduces postprandial glucose in patients with uncontrolled type 2 diabetes
    Ji‐Hyun Kim, Ji‐Hyun Ahn, Soo‐Kyung Kim, Dae‐Ho Lee, Hye‐Soon Kim, Ho‐Sang Shon, Hyun‐Jeong Jeon, Tae‐Hwa Kim, Yong‐Wook Cho, Jae‐Taek Kim, Sung‐Min Han, Choon‐Hee Chung, Ohk‐Hyun Ryu, Jae‐Min Lee, Soon‐Hee Lee, Min‐Jeong Kwon, Tae‐kyun Kim, Il‐Seong Namg
    Journal of Diabetes Investigation.2015; 6(2): 219.     CrossRef
  • Anti-Oxidative and Anti-Diabetic Effects of Methanol Extracts from Medicinal Plants
    Youn Ri Lee, Nara Yoon
    Journal of the Korean Society of Food Science and Nutrition.2015; 44(5): 681.     CrossRef
  • Associations Between the Continuity of Ambulatory Care of Adult Diabetes Patients in Korea and the Incidence of Macrovascular Complications
    Young-Hoon Gong, Seok-Jun Yoon, Hyeyoung Seo, Dongwoo Kim
    Journal of Preventive Medicine and Public Health.2015; 48(4): 188.     CrossRef
  • Statin eligibility and cardiovascular risk burden assessed by coronary artery calcium score: Comparing the two guidelines in a large Korean cohort
    Eun-Jung Rhee, Se Eun Park, Hyung Geun Oh, Cheol-Young Park, Ki-Won Oh, Sung-Woo Park, Ron Blankstein, Jorge Plutzky, Won-Young Lee
    Atherosclerosis.2015; 240(1): 242.     CrossRef
  • Evaluation of low-dose aspirin for primary prevention of ischemic stroke among patients with diabetes: a retrospective cohort study
    Ye-Jee Kim, Nam-Kyong Choi, Mi-Sook Kim, Joongyub Lee, Yoosoo Chang, Jong-Mi Seong, Sun-Young Jung, Ju-Young Shin, Ji-Eun Park, Byung-Joo Park
    Diabetology & Metabolic Syndrome.2015;[Epub]     CrossRef
  • Health-Related Quality of Life in Coronary Heart Disease in Korea
    Hyung Tak Lee, Jinho Shin, Young-Hyo Lim, Kyung Soo Kim, Soon Gil Kim, Jeong Hyun Kim, Heon Kil Lim
    Angiology.2015; 66(4): 326.     CrossRef
  • Seroepidemiology of varicella-zoster virus in Korean adolescents and adults using fluorescent antibody to membrane antigen test
    S. B. HAN, K. R. KANG, D. H. HUH, H. C. LEE, J. H. KIM, J. H. KANG, S. H. MA
    Epidemiology and Infection.2015; 143(8): 1643.     CrossRef
  • Changing Clinical Characteristics according to Insulin Resistance and Insulin Secretion in Newly Diagnosed Type 2 Diabetic Patients in Korea
    Jang Won Son, Cheol-Young Park, Sungrae Kim, Han-Kyu Lee, Yil-Seob Lee
    Diabetes & Metabolism Journal.2015; 39(5): 387.     CrossRef
  • Age- and Sex-Specific Relationships between Household Income, Education, and Diabetes Mellitus in Korean Adults: The Korea National Health and Nutrition Examination Survey, 2008-2010
    So-Ra Kim, Kyungdo Han, Jin-Young Choi, Jennifer Ersek, Junxiu Liu, Sun-Jin Jo, Kang-Sook Lee, Hyeon Woo Yim, Won-Chul Lee, Yong Gyu Park, Seung-Hwan Lee, Yong-Moon Park, C. Mary Schooling
    PLOS ONE.2015; 10(1): e0117034.     CrossRef
  • Association between Diabetes Education Status and Clinical Outcomes of Patients with Diabetes Mellitus: Analysis of the Fifth Korea National Health and Nutrition Examination Survey (KNHANES V)
    Jun Sung Kwon, Won Jun Kim, Yang Hee Han, Hyun Joong Kim, Sa Young Shin, Kyoo Ho Choi, Jae Hyuck Jun, Myoung Sook Shim, Jin Yeob Kim
    The Journal of Korean Diabetes.2014; 15(4): 236.     CrossRef
  • The Incidence and Prevalence of Diabetes Mellitus and Related Atherosclerotic Complications in Korea: A National Health Insurance Database Study
    Bo Kyung Koo, Chang-Hoon Lee, Bo Ram Yang, Seung-sik Hwang, Nam-Kyong Choi, Mohammad Ebrahim Khamseh
    PLoS ONE.2014; 9(10): e110650.     CrossRef
  • Current Status of Glycemic Control of Patients with Diabetes in Korea: The Fifth Korea National Health and Nutrition Examination Survey
    Ja Young Jeon, Dae Jung Kim, Seung-Hyun Ko, Hyuk-Sang Kwon, Soo Lim, Sung Hee Choi, Chul Sik Kim, Jee Hyun An, Nan Hee Kim, Jong Chul Won, Jae Hyeon Kim, Bong-Yun Cha, Kee-Ho Song
    Diabetes & Metabolism Journal.2014; 38(3): 197.     CrossRef
  • Strong correlation between glycaemic variability and total glucose exposure in type 2 diabetes is limited to subjects with satisfactory glycaemic control
    S. Suh, J.Y. Joung, S.M. Jin, M.Y. Kim, J.C. Bae, H.D. Park, M.S. Lee, M.K. Lee, J.H. Kim
    Diabetes & Metabolism.2014; 40(4): 272.     CrossRef
  • Current Status of Diabetic Peripheral Neuropathy in Korea: Report of a Hospital-Based Study of Type 2 Diabetic Patients in Korea by the Diabetic Neuropathy Study Group of the Korean Diabetes Association
    Jong Chul Won, Sang Soo Kim, Kyung Soo Ko, Bong-Yun Cha
    Diabetes & Metabolism Journal.2014; 38(1): 25.     CrossRef
  • Impact of Age at First Childbirth on Glucose Tolerance Status in Postmenopausal Women: The 2008–2011 Korean National Health and Nutrition Examination Survey
    Jin Hwa Kim, Yun Jung, Sang Yong Kim, Hak Yeon Bae
    Diabetes Care.2014; 37(3): 671.     CrossRef
  • Predicting the Development of Diabetes Using the Product of Triglycerides and Glucose: The Chungju Metabolic Disease Cohort (CMC) Study
    Seung-Hwan Lee, Hyuk-Sang Kwon, Yong-Moon Park, Hee-Sung Ha, Seung Hee Jeong, Hae Kyung Yang, Jin-Hee Lee, Hyeon-Woo Yim, Moo-Il Kang, Won-Chul Lee, Ho-Young Son, Kun-Ho Yoon, Maria Eugenia Saez
    PLoS ONE.2014; 9(2): e90430.     CrossRef
  • Relationship between socioeconomic status and type 2 diabetes: results from Korea National Health and Nutrition Examination Survey (KNHANES) 2010-2012
    J. Hwang, C. Shon
    BMJ Open.2014; 4(8): e005710.     CrossRef
  • Diabetes Mellitus and Osteoporosis
    Kyoung Min Kim
    The Journal of Korean Diabetes.2013; 14(4): 186.     CrossRef
  • Study on the Correlation between the Nutrient Intakes and Clinical Indices of Type 2 Diabetes Patients
    Ji-Young Kwon, Hae-Yun Chung
    The Korean Journal of Food And Nutrition.2013; 26(4): 909.     CrossRef
  • Role of Sarcopenia in Diabetes Mellitus
    Sang Youl Rhee
    The Journal of Korean Diabetes.2013; 14(4): 178.     CrossRef
Beneficial Effects of Omega-3 Fatty Acids on Low Density Lipoprotein Particle Size in Patients with Type 2 Diabetes Already under Statin Therapy
Myung Won Lee, Jeong Kyung Park, Jae Won Hong, Kwang Joon Kim, Dong Yeob Shin, Chul Woo Ahn, Young Duk Song, Hong Keun Cho, Seok Won Park, Eun Jig Lee
Diabetes Metab J. 2013;37(3):207-211.   Published online June 14, 2013
DOI: https://doi.org/10.4093/dmj.2013.37.3.207
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AbstractAbstract PDFPubReader   

Beyond statin therapy for reducing low density lipoprotein cholesterol (LDL-C), additional therapeutic strategies are required to achieve more optimal reduction in cardiovascular risk among diabetic patients with dyslipidemia. To evaluate the effects and the safety of combined treatment with omega-3 fatty acids and statin in dyslipidemic patients with type 2 diabetes, we conducted a randomized, open-label study in Korea. Patients with persistent hypertriglyceridemia (≥200 mg/dL) while taking statin for at least 6 weeks were eligible. Fifty-one patients were randomized to receive either omega-3 fatty acid 4, 2 g, or no drug for 8 weeks while continuing statin therapy. After 8 weeks of treatment, the mean percentage change of low density lipoprotein (LDL) particle size and triglyceride (TG) level was greater in patients who were prescribed 4 g of omega-3 fatty acid with statin than in patients receiving statin monotherapy (2.8%±3.1% vs. 2.3%±3.6%, P=0.024; -41.0%±24.1% vs. -24.2%±31.9%, P=0.049). Coadministration of omega-3 fatty acids with statin increased LDL particle size and decreased TG level in dyslipidemic patients with type 2 diabetes. The therapy was well tolerated without significant adverse effects.

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  • Diabetic cardiac autonomic neuropathy: insulin resistance, lipid profile, and omega-3 polyunsaturated fatty acids
    Martin-Yurii Markevich, Volodymyr Segin, Victoria Serhiyenko, Alexandr Serhiyenko
    InterConf.2023; (35(163)): 213.     CrossRef
  • Atherogenic features of the fatty acid profile of erythrocyte membranes of patients with fatty liver disease of mixed genesis
    M. V. Kruchinina, A. V. Belkovets, M. V. Parulikova, A. A. Gromov
    Ateroscleroz.2023; 19(4): 350.     CrossRef
  • Omega-3 supplementation in the treatment of polycystic ovary syndrome (PCOS) – a review of clinical trials and cohort
    Vitoria Melo, Thomas Silva, Thaissa Silva, Juliana Freitas, Joselita Sacramento, Mirian Vazquez, Edilene Araujo
    Endocrine Regulations.2022; 56(1): 66.     CrossRef
  • Nutrigenetics, omega-3 and plasma lipids/lipoproteins/apolipoproteins with evidence evaluation using the GRADE approach: a systematic review
    Justine Keathley, Véronique Garneau, Valérie Marcil, David M Mutch, Julie Robitaille, Iwona Rudkowska, Gabriela Magdalena Sofian, Sophie Desroches, Marie-Claude Vohl
    BMJ Open.2022; 12(2): e054417.     CrossRef
  • N-3 fatty acid supplementation mediates lipid profile, including small dense LDL, when combined with statins: a randomized double blind placebo controlled trial
    Gediz Dogay Us, Sohail Mushtaq
    Lipids in Health and Disease.2022;[Epub]     CrossRef
  • The effect of omega-3 fatty acids and its combination with statins on lipid profile in patients with hypertriglyceridemia: A systematic review and meta-analysis of randomized controlled trials
    Yunjiao Yang, Wen Deng, Yanmei Wang, Tongyi Li, Yiding Chen, Cong Long, Qing Wen, Yue Wu, Qiu Chen
    Frontiers in Nutrition.2022;[Epub]     CrossRef
  • Study of the Healthy Effects of Different Fat Ratios Mixtures of Omega-3 to Omega-6 in Male Mice with Alloxan-Induced Diabetes
    Ali. M. Atallah, Faryal. F. Hussein
    Tikrit journal for agricultural sciences.2021; 21(4): 129.     CrossRef
  • Omega-3 Fatty Acids as Druggable Therapeutics for Neurodegenerative Disorders
    Neha M. Chitre, Nader H. Moniri, Kevin S. Murnane
    CNS & Neurological Disorders - Drug Targets.2020; 18(10): 735.     CrossRef
  • Efficacy and Safety of Omega-3 Fatty Acids in Patients Treated with Statins for Residual Hypertriglyceridemia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
    Ji Eun Jun, In-Kyung Jeong, Jae Myung Yu, Sung Rae Kim, In Kye Lee, Kyung-Ah Han, Sung Hee Choi, Soo-Kyung Kim, Hyeong Kyu Park, Ji-Oh Mok, Yong-ho Lee, Hyuk-Sang Kwon, So Hun Kim, Ho-Cheol Kang, Sang Ah Lee, Chang Beom Lee, Kyung Mook Choi, Sung-Ho Her,
    Diabetes & Metabolism Journal.2020; 44(1): 78.     CrossRef
  • The combination of canagliflozin and omega-3 fatty acid ameliorates insulin resistance and cardiac biomarkersviamodulation of inflammatory cytokines in type 2 diabetic rats
    Mohammed Mohsen Safhi, Tarique Anwer, Gyas Khan, Rahimullah Siddiqui, Sivagurunathan Moni Sivakumar, Mohammad Firoz Alam
    The Korean Journal of Physiology & Pharmacology.2018; 22(5): 493.     CrossRef
  • Effect of diets rich in either saturated fat or n-6 polyunsaturated fatty acids and supplemented with long-chain n-3 polyunsaturated fatty acids on plasma lipoprotein profiles
    C B Dias, N Amigo, L G Wood, X Correig, M L Garg
    European Journal of Clinical Nutrition.2017; 71(11): 1297.     CrossRef
  • Effects of 12-week supplementation of marine Omega-3 PUFA-based formulation Omega3Q10 in older adults with prehypertension and/or elevated blood cholesterol
    Tian Shen, Guoqiang Xing, Jingfen Zhu, Shuxian Zhang, Yong Cai, Donghua Li, Gang Xu, Evan Xing, Jianyu Rao, Rong Shi
    Lipids in Health and Disease.2017;[Epub]     CrossRef
  • Effects of dietary saturated and n-6 polyunsaturated fatty acids on the incorporation of long-chain n-3 polyunsaturated fatty acids into blood lipids
    C B Dias, L G Wood, M L Garg
    European Journal of Clinical Nutrition.2016; 70(7): 812.     CrossRef
  • Comparative analysis of the efficacy of omega-3 fatty acids for hypertriglyceridaemia management in Korea
    H.-S. Kim, H. Kim, Y. J. Jeong, S. J. Yang, S. J. Baik, H. Lee, S.-H. Lee, J. H. Cho, I.-Y. Choi, H. W. Yim, K.-H. Yoon
    Journal of Clinical Pharmacy and Therapeutics.2016; 41(5): 508.     CrossRef
  • Effects of Omega-3 Fatty Acid Supplementation on Diabetic Nephropathy Progression in Patients with Diabetes and Hypertriglyceridemia
    Eugene Han, Yujung Yun, Gyuri Kim, Yong-ho Lee, Hye Jin Wang, Byung-Wan Lee, Bong Soo Cha, Beom Seok Kim, Eun Seok Kang, Wolf-Hagen Schunck
    PLOS ONE.2016; 11(5): e0154683.     CrossRef
  • The clinical relevance of omega-3 fatty acids in the management of hypertriglyceridemia
    James Backes, Deborah Anzalone, Daniel Hilleman, Julia Catini
    Lipids in Health and Disease.2016;[Epub]     CrossRef
  • Supercritical fluid extraction of grape seeds: extract chemical composition, antioxidant activity and inhibition of nitrite production in LPS-stimulated Raw 264.7 cells
    Concepción Pérez, María Luisa Ruiz del Castillo, Carmen Gil, Gracia Patricia Blanch, Gema Flores
    Food & Function.2015; 6(8): 2607.     CrossRef
  • Omega-3 Polyunsaturated Fatty Acids May Attenuate Streptozotocin-Induced Pancreatic β-Cell Death via Autophagy Activation in Fat1 Transgenic Mice
    Won-Min Hwang, Dong-Ho Bak, Dong Ho Kim, Ju Young Hong, Seung-Yun Han, Keun-Young Park, Kyu Lim, Dong-Mee Lim, Jae Gu Kang
    Endocrinology and Metabolism.2015; 30(4): 569.     CrossRef
  • Long-chain omega-3 fatty acids, fibrates and niacin as therapeutic options in the treatment of hypertriglyceridemia: A review of the literature
    Matthew K. Ito
    Atherosclerosis.2015; 242(2): 647.     CrossRef
  • Nutraceuticals and dyslipidaemia: Beyond the common therapeutics
    Pietro Scicchitano, Matteo Cameli, Maria Maiello, Pietro Amedeo Modesti, Maria Lorenza Muiesan, Salvatore Novo, Pasquale Palmiero, Pier Sergio Saba, Roberto Pedrinelli, Marco Matteo Ciccone
    Journal of Functional Foods.2014; 6: 11.     CrossRef
  • The effect of dietary omega-3 polyunsaturated fatty acids on plasma lipids and lipoproteins of C57BL/6 mice is age and sex specific
    K.A. Balogun, R.S. Randunu, S.K. Cheema
    Prostaglandins, Leukotrienes and Essential Fatty Acids.2014; 91(1-2): 39.     CrossRef
  • Gene-diet interactions with polymorphisms of the MGLL gene on plasma low-density lipoprotein cholesterol and size following an omega-3 polyunsaturated fatty acid supplementation: a clinical trial
    Catherine Ouellette, Iwona Rudkowska, Simone Lemieux, Benoit Lamarche, Patrick Couture, Marie-Claude Vohl
    Lipids in Health and Disease.2014;[Epub]     CrossRef
  • Saturated fat consumption may not be the main cause of increased blood lipid levels
    C.B. Dias, R. Garg, L.G. Wood, M.L. Garg
    Medical Hypotheses.2014; 82(2): 187.     CrossRef
Management of Type 2 Diabetes Mellitus in Older Adults
Kyung Soo Kim, Soo Kyung Kim, Kyung Mi Sung, Yong Wook Cho, Seok Won Park
Diabetes Metab J. 2012;36(5):336-344.   Published online October 18, 2012
DOI: https://doi.org/10.4093/dmj.2012.36.5.336
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AbstractAbstract PDFPubReader   

In the near future, the majority of patients with diabetes will be adults aged 65 or older. Unlike young adults with diabetes, elderly diabetic people may be affected by a variety of comorbid conditions such as depression, cognitive impairment, muscle weakness (sarcopenia), falls and fractures, and physical frailty. These geriatric syndromes should be considered in the establishment of treatment goals in older adults with diabetes. Although there are several guidelines for the management of diabetes, only a few are specifically designed for the elderly with diabetes. In this review, we present specific conditions of elderly diabetes which should be taken into account in the management of diabetes in older adults. We also present advantages and disadvantages of various glucose-lowering agents that should be considered when choosing a proper regimen for older adults with diabetes.

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    European Journal of Sport Science.2023; 23(8): 1710.     CrossRef
  • Glucose Sensors Based on Chitosan Capped ZnS Doped Mn Nanomaterials
    Son Hai Nguyen, Phan Kim Thi Vu, Mai Thi Tran
    IEEE Sensors Letters.2023; 7(2): 1.     CrossRef
  • Inhibitory Potential of α-Amylase, α-Glucosidase, and Pancreatic Lipase by a Formulation of Five Plant Extracts: TOTUM-63
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    International Journal of Molecular Sciences.2023; 24(4): 3652.     CrossRef
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    Sensors.2023; 23(5): 2841.     CrossRef
  • Meta‐analysis of factors associated with antidiabetic drug prescribing for type 2 diabetes mellitus
    Fatema Mahmoud, Alexander Mullen, Chris Sainsbury, Gordon F. Rushworth, Haya Yasin, Nouf Abutheraa, Tanja Mueller, Amanj Kurdi
    European Journal of Clinical Investigation.2023;[Epub]     CrossRef
  • Efficacy and safety of oral semaglutide by baseline age in Japanese patients with type 2 diabetes: A subgroup analysis of the PIONEER 9 and 10 Japan trials
    Yuichiro Yamada, Daisuke Yabe, Christin Løth Hertz, Hiroshi Horio, Jiro Nakamura, Anne Møller Nielsen, Yutaka Seino
    Diabetes, Obesity and Metabolism.2022; 24(2): 321.     CrossRef
  • A Low Free T3 to Free T4 Ratio Is Associated with Sarcopenia in Euthyroid Patients with Type 2 Diabetes Mellitus
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    Journal of Diabetes Research.2022; 2022: 1.     CrossRef
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    Nutrients.2022; 14(15): 3225.     CrossRef
  • Education for Insulin Injection in Elderly Diabetic Patients
    Gi Yeon Lee
    The Journal of Korean Diabetes.2022; 23(3): 201.     CrossRef
  • Diabetes Mellitus: Insights from Epidemiology, Biochemistry, Risk Factors, Diagnosis, Complications and Comprehensive Management
    Saruar Alam, Md. Kamrul Hasan, Sharif Neaz, Nazmul Hussain, Md. Faruk Hossain, Tania Rahman
    Diabetology.2021; 2(2): 36.     CrossRef
  • Characteristics of the clinical treatment of Brazilian and French older adults with diabetes
    Carina Bandeira Bezerra, Claudio de Brito Ramos Pinto Pinho, Maria Vieira de Lima Saintrain, Ana Karina de Melo Bezerra Sodré, Carlos Antonio Bruno da Silva, Jean Doucet
    Diabetes Research and Clinical Practice.2021; 181: 109088.     CrossRef
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    International Journal of Cardiology.2020; 316: 7.     CrossRef
  • Association of traditional and novel measures of central obesity with cognitive performance in older multi‐ethnic Asians with type 2 diabetes
    Mei Chung Moh, Serena Low, Tze Pin Ng, Jiexun Wang, Su Fen Ang, Clara Tan, Keven Ang, Subramaniam Tavintharan, Chee Fang Sum, Pek Yee Kwan, Simon Biing Ming Lee, Wern Ee Tang, Su Chi Lim
    Clinical Obesity.2020;[Epub]     CrossRef
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    The Journal of Korean Diabetes.2018; 19(1): 58.     CrossRef
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    Diabetes Therapy.2018; 9(2): 827.     CrossRef
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    Geriatrics & Gerontology International.2017; 17(7): 1069.     CrossRef
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    Diabetes & Metabolism Journal.2017; 41(3): 213.     CrossRef
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    International Journal of Cardiology.2017; 241: 35.     CrossRef
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    Endocrinology and Metabolism.2016; 31(3): 416.     CrossRef
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    Diabetes, Obesity and Metabolism.2016; 18(5): 528.     CrossRef
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    Hepatology.2014; 59(5): 1772.     CrossRef
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The Association of Unintentional Changes in Weight, Body Composition, and Homeostasis Model Assessment Index with Glycemic Progression in Non-Diabetic Healthy Subjects
Eun-Jung Rhee, Ji-Hun Choi, Seung-Hyun Yoo, Ji-Cheol Bae, Won-Jun Kim, Eun-Suk Choi, Se Eun Park, Cheol-Young Park, Seok Won Park, Ki-Won Oh, Sung-Woo Park, Sun-Woo Kim, Won-Young Lee
Diabetes Metab J. 2011;35(2):138-148.   Published online April 30, 2011
DOI: https://doi.org/10.4093/dmj.2011.35.2.138
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AbstractAbstract PDFPubReader   
Background

We performed a retrospective longitudinal study on the effects of changes in weight, body composition, and homeostasis model assessment (HOMA) indices on glycemic progression in subjects without diabetes during a four-year follow-up period in a community cohort without intentional intervention.

Methods

From 28,440 non-diabetic subjects who participated in a medical check-up program in 2004, data on anthropometric and metabolic parameters were obtained after four years in 2008. Body composition analyses were performed with a bioelectrical impedance analyzer. Skeletal muscle index (SMI, %) was calculated with lean mass/weight×100. Subjects were divided into three groups according to weight change status in four years: weight loss (≤-5.0%), stable weight (-5.0 to 5.0%), weight gain (≥5.0%). Progressors were defined as the subjects who progressed to impaired fasting glucose or diabetes.

Results

Progressors showed worse baseline metabolic profiles compared with non-progressors. In logistic regression analyses, the increase in changes of HOMA-insulin resistance (HOMA-IR) in four years presented higher odds ratios for glycemic progression compared with other changes during that period. Among the components of body composition, a change in waist-hip ratio was the strongest predictor, and SMI change in four years was a significant negative predictor for glycemic progression. Changes in HOMA β-cell function in four years was a negative predictor for glycemic progression.

Conclusion

Increased interval changes in HOMA-IR, weight gain and waist-hip ratio was associated with glycemic progression during a four-year period without intentional intervention in non-diabetic Korean subjects.

Citations

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  • Increased Risk of Nonalcoholic Fatty Liver Disease in Individuals with High Weight Variability
    Inha Jung, Dae-Jeong Koo, Mi Yeon Lee, Sun Joon Moon, Hyemi Kwon, Se Eun Park, Eun-Jung Rhee, Won-Young Lee
    Endocrinology and Metabolism.2021; 36(4): 845.     CrossRef
  • Effects of nutritional supplementation on glucose metabolism and insulin function among people with HIV initiating ART
    Hiwot Amare, Mette F. Olsen, Henrik Friis, Pernille Kæstel, Åse B. Andersen, Alemseged Abdissa, Daniel Yilma, Tsinuel Girma, Daniel Faurholt-Jepsen
    BMC Nutrition.2021;[Epub]     CrossRef
  • The ratio of estimated average glucose to fasting plasma glucose level as an indicator of insulin resistance in young adult diabetes
    Jun Guo, Sisi Lei, Yu Zhou, Congqing Pan
    Medicine.2020; 99(40): e22337.     CrossRef
  • Reduced Skeletal Muscle Volume and Increased Skeletal Muscle Fat Deposition Characterize Diabetes in Individuals after Pancreatitis: A Magnetic Resonance Imaging Study
    Andre E. Modesto, Juyeon Ko, Charlotte E. Stuart, Sakina H. Bharmal, Jaelim Cho, Maxim S. Petrov
    Diseases.2020; 8(3): 25.     CrossRef
  • Insulin resistance increases the risk of incident type 2 diabetes mellitus in patients with non‐alcoholic fatty liver disease
    Yuya Seko, Yoshio Sumida, Saiyu Tanaka, Kojiroh Mori, Hiroyoshi Taketani, Hiroshi Ishiba, Tasuku Hara, Akira Okajima, Atsushi Umemura, Taichiro Nishikawa, Kanji Yamaguchi, Michihisa Moriguchi, Kazuyuki Kanemasa, Kohichiroh Yasui, Shunsuke Imai, Keiji Shim
    Hepatology Research.2018;[Epub]     CrossRef
  • Use of Novel High-Protein Functional Food Products as Part of a Calorie-Restricted Diet to Reduce Insulin Resistance and Increase Lean Body Mass in Adults: A Randomized Controlled Trial
    Carol Johnston, Barry Sears, Mary Perry, Jessica Knurick
    Nutrients.2017; 9(11): 1182.     CrossRef
  • Gender differences in the association between food insecurity and insulin resistance among U.S. adults: National Health and Nutrition Examination Survey, 2005–2010
    Junxiu Liu, Yong-Moon Mark Park, Seth A. Berkowitz, Qingwei Hu, Kyungdo Han, Andrew Ortaglia, Robert E. McKeown, Angela D. Liese
    Annals of Epidemiology.2015; 25(9): 643.     CrossRef
  • 1,5-Anhydroglucitol Is Associated with Early-Phase Insulin Secretion in Chinese Patients with Newly Diagnosed Type 2 Diabetes Mellitus
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    Diabetes Technology & Therapeutics.2015; 17(5): 320.     CrossRef
  • Serum glycated albumin as a new glycemic marker in pediatric diabetes
    Ji Woo Lee, Hyung Jin Kim, Young Se Kwon, Yong Hoon Jun, Soon Ki Kim, Jong Weon Choi, Ji Eun Lee
    Annals of Pediatric Endocrinology & Metabolism.2013; 18(4): 208.     CrossRef
  • The Association of Maximum Body Weight on the Development of Type 2 Diabetes and Microvascular Complications: MAXWEL Study
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    PLoS ONE.2013; 8(12): e80525.     CrossRef
  • Relative contributions of insulin resistance and β‐cell dysfunction to the development of Type 2 diabetes in Koreans
    C.‐H. Kim, H.‐K. Kim, E. H. Kim, S. J. Bae, J.‐Y. Park
    Diabetic Medicine.2013; 30(9): 1075.     CrossRef
  • Body Mass Index and Waist Circumference According to Glucose Tolerance Status in Korea: The 2005 Korean Health and Nutrition Examination Survey
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    Journal of Korean Medical Science.2012; 27(5): 518.     CrossRef
  • The Relationship between β-cell Function and Nutrient Intakes in Korean Adult - Using 4thKorea National Health and Nutrition Examination Survey 2009 -
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    Korean Journal of Community Nutrition.2012; 17(2): 243.     CrossRef
  • The ratio of glycated albumin to glycated haemoglobin correlates with insulin secretory function
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    Clinical Endocrinology.2012; 77(5): 679.     CrossRef

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