- Complications
- Pathophysiology of Diabetic Retinopathy: The Old and the New
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Sentaro Kusuhara, Yoko Fukushima, Shuntaro Ogura, Naomi Inoue, Akiyoshi Uemura
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Diabetes Metab J. 2018;42(5):364-376. Published online October 22, 2018
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DOI: https://doi.org/10.4093/dmj.2018.0182
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Abstract
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Vision loss in diabetic retinopathy (DR) is ascribed primarily to retinal vascular abnormalities—including hyperpermeability, hypoperfusion, and neoangiogenesis—that eventually lead to anatomical and functional alterations in retinal neurons and glial cells. Recent advances in retinal imaging systems using optical coherence tomography technologies and pharmacological treatments using anti-vascular endothelial growth factor drugs and corticosteroids have revolutionized the clinical management of DR. However, the cellular and molecular mechanisms underlying the pathophysiology of DR are not fully determined, largely because hyperglycemic animal models only reproduce limited aspects of subclinical and early DR. Conversely, non-diabetic mouse models that represent the hallmark vascular disorders in DR, such as pericyte deficiency and retinal ischemia, have provided clues toward an understanding of the sequential events that are responsible for vision-impairing conditions. In this review, we summarize the clinical manifestations and treatment modalities of DR, discuss current and emerging concepts with regard to the pathophysiology of DR, and introduce perspectives on the development of new drugs, emphasizing the breakdown of the blood-retina barrier and retinal neovascularization.
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Suiping Li, Hong Liu, Xian Zhu Medicine.2021; 100(51): e28386. CrossRef - Changes in Ocular Blood Flow after Ranibizumab Intravitreal Injection for Diabetic Macular Edema Measured Using Laser Speckle Flowgraphy
Lisa Toto, Federica Evangelista, Pasquale Viggiano, Emanuele Erroi, Giada D’Onofrio, Daniele Libertini, Annamaria Porreca, Rossella D’Aloisio, Parravano Mariacristina, Luca Di Antonio, Marta Di Nicola, Rodolfo Mastropasqua BioMed Research International.2020; 2020: 1. CrossRef - microRNA Expression Profile in the Vitreous of Proliferative Diabetic Retinopathy Patients and Differences from Patients Treated with Anti-VEGF Therapy
Julian Friedrich, David H. W. Steel, Reinier O. Schlingemann, Michael J. Koss, Hans-Peter Hammes, Guido Krenning, Ingeborg Klaassen Translational Vision Science & Technology.2020; 9(6): 16. CrossRef - Update on the Effects of Antioxidants on Diabetic Retinopathy: In Vitro Experiments, Animal Studies and Clinical Trials
Jose Javier Garcia-Medina, Elena Rubio-Velazquez, Elisa Foulquie-Moreno, Ricardo P Casaroli-Marano, Maria Dolores Pinazo-Duran, Vicente Zanon-Moreno, Monica del-Rio-Vellosillo Antioxidants.2020; 9(6): 561. CrossRef - Methylglyoxal, a Highly Reactive Dicarbonyl Compound, in Diabetes, Its Vascular Complications, and Other Age-Related Diseases
C. G. Schalkwijk, C. D. A. Stehouwer Physiological Reviews.2020; 100(1): 407. CrossRef - Pericytes, inflammation, and diabetic retinopathy
Benjamin G. Spencer, Jose J. Estevez, Ebony Liu, Jamie E. Craig, John W. Finnie Inflammopharmacology.2020; 28(3): 697. CrossRef - Eye hemodynamic data and biochemical parameters of the lacrimal fluid of patients with non-proliferative diabetic retinopathy
Guzal Kangilbaeva, Fazilat Bakhritdinova, Iroda Nabieva, Aziza Jurabekova Data in Brief.2020; 32: 106237. CrossRef - Endocannabinoids in aqueous humour of patients with or without diabetes
Patrick Richardson, Catherine Ortori, Dave Barrett, Saoirse O'Sullivan, Iskandar Idris BMJ Open Ophthalmology.2020; 5(1): e000425. CrossRef - A pyruvate dehydrogenase kinase inhibitor prevents retinal cell death and improves energy metabolism in rat retinas after ischemia/reperfusion injury
Kota Sato, Seiya Mochida, Daisuke Tomimoto, Takahiro Konuma, Naoki Kiyota, Satoru Tsuda, Yukihiro Shiga, Kazuko Omodaka, Toru Nakazawa Experimental Eye Research.2020; 193: 107997. CrossRef - The Role of Bone Morphogenetic Proteins in Diabetic Complications
Nimna Perera, Rebecca H. Ritchie, Mitchel Tate ACS Pharmacology & Translational Science.2020; 3(1): 11. CrossRef - Increased Ephrin-B2 expression in pericytes contributes to retinal vascular death in rodents
Maha Coucha, Amy C. Barrett, Joseph Bailey, Maryam Abdelghani, Mohammed Abdelsaid Vascular Pharmacology.2020; 131: 106761. CrossRef - Mitochondrial Defects Drive Degenerative Retinal Diseases
Deborah A. Ferrington, Cody R. Fisher, Renu A. Kowluru Trends in Molecular Medicine.2020; 26(1): 105. CrossRef - Fli1 deficiency induces endothelial adipsin expression, contributing to the onset of pulmonary arterial hypertension in systemic sclerosis
Takuya Miyagawa, Takashi Taniguchi, Ryosuke Saigusa, Maiko Fukayama, Takehiro Takahashi, Takashi Yamashita, Megumi Hirabayashi, Shunsuke Miura, Kouki Nakamura, Ayumi Yoshizaki, Shinichi Sato, Yoshihide Asano Rheumatology.2020; 59(8): 2005. CrossRef - Natriuretic Peptides Attenuate Retinal Pathological Neovascularization Via Cyclic Guanosine Monophosphate Signaling in Pericytes and Astrocytes
Katarina Špiranec Spes, Sabrina Hupp, Franziska Werner, Franziska Koch, Katharina Völker, Lisa Krebes, Ulrike Kämmerer, Katrin G. Heinze, Barbara M. Braunger, Michaela Kuhn Arteriosclerosis, Thrombosis, and Vascular Biology.2020; 40(1): 159. CrossRef - Therapeutic investigation of quercetin nanomedicine in a zebrafish model of diabetic retinopathy
Shuai Wang, Shanshan Du, Wenzhan Wang, Fengyan Zhang Biomedicine & Pharmacotherapy.2020; 130: 110573. CrossRef - The role of CD44 in pathological angiogenesis
Li Chen, Chenying Fu, Qing Zhang, Chengqi He, Feng Zhang, Quan Wei The FASEB Journal.2020; 34(10): 13125. CrossRef - Associations between alcohol intake and diabetic retinopathy risk: a systematic review and meta-analysis
Chen Chen, Zhaojun Sun, Weigang Xu, Jun Tan, Dan Li, Yiting Wu, Ting Zheng, Derong Peng BMC Endocrine Disorders.2020;[Epub] CrossRef - Alpha-Smooth Muscle Actin-Positive Perivascular Cells in Diabetic Retina and Choroid
Soo Jin Kim, Sang A. Kim, Yeong A. Choi, Do Young Park, Junyeop Lee International Journal of Molecular Sciences.2020; 21(6): 2158. CrossRef - The G‐protein‐coupled chemoattractant receptor Fpr2 exacerbates neuroglial dysfunction and angiogenesis in diabetic retinopathy
Ying Yu, Shengding Xue, Keqiang Chen, Yingying Le, Rongrong Zhu, Shiyi Wang, Shuang Liu, Xinliang Cheng, Huaijin Guan, Ji Ming Wang, Hui Chen FASEB BioAdvances.2020; 2(10): 613. CrossRef - Dual-Acting Antiangiogenic Gene Therapy Reduces Inflammation and Regresses Neovascularization in Diabetic Mouse Retina
Rute S. Araújo, Diogo B. Bitoque, Gabriela A. Silva Molecular Therapy - Nucleic Acids.2020; 22: 329. CrossRef - The cells involved in the pathological process of diabetic retinopathy
Songtao Yang, Jiaoyue Zhang, Lulu Chen Biomedicine & Pharmacotherapy.2020; 132: 110818. CrossRef - The Role of Transforming Growth Factor-Beta in Retinal Ganglion Cells with Hyperglycemia and Oxidative Stress
Hsin-Yi Chen, Yi-Jung Ho, Hsiu-Chuan Chou, En-Chi Liao, Yi-Ting Tsai, Yu-Shan Wei, Li-Hsun Lin, Meng-Wei Lin, Yi-Shiuan Wang, Mei-Lan Ko, Hong-Lin Chan International Journal of Molecular Sciences.2020; 21(18): 6482. CrossRef - Circadian rhythms in diabetic retinopathy: an overview of pathogenesis and investigational drugs
Ashay D. Bhatwadekar, Varun Rameswara Expert Opinion on Investigational Drugs.2020; 29(12): 1431. CrossRef - Blood-retinal barrier as a converging pivot in understanding the initiation and development of retinal diseases
Xue Yang, Xiao-Wei Yu, Dan-Dan Zhang, Zhi-Gang Fan Chinese Medical Journal.2020; 133(21): 2586. CrossRef - Immunosubunit β5i Knockout Suppresses Neovascularization and Restores Autophagy in Retinal Neovascularization by Targeting ATG5 for Degradation
Liyang Ji, Li Li, Ying Zhao, Shengqiang Liu, Jingmin Li, Jinsong Zhang, Qi Zhao, Shuai Wang Investigative Opthalmology & Visual Science.2020; 61(14): 30. CrossRef - En face slab optical coherence tomography imaging successfully monitors progressive degenerative changes in the innermost layer of the diabetic retina
Atsuko Katsuyama, Sentaro Kusuhara, Shun-Ichiro Asahara, Shun-Ichiro Nakai, Sotaro Mori, Wataru Matsumiya, Akiko Miki, Takuji Kurimoto, Hisanori Imai, Yoshiaki Kido, Wataru Ogawa, Makoto Nakamura BMJ Open Diabetes Research & Care.2020; 8(1): e001120. CrossRef - Dipeptidyl Peptidase-4 Inhibitors versus Other Antidiabetic Drugs Added to Metformin Monotherapy in Diabetic Retinopathy Progression: A Real World-Based Cohort Study
Yoo-Ri Chung, Kyoung Hwa Ha, Hyeon Chang Kim, Sang Jun Park, Kihwang Lee, Dae Jung Kim Diabetes & Metabolism Journal.2019; 43(5): 640. CrossRef - Age-related changes of the human retinal vessels: Possible involvement of lipid peroxidation
Tapas Chandra Nag, Meenakshi Maurya, Tara Sankar Roy Annals of Anatomy - Anatomischer Anzeiger.2019; 226: 35. CrossRef - Human iPSCs-Derived Endothelial Cells with Mutation in HNF1A as a Model of Maturity-Onset Diabetes of the Young
Neli Kachamakova-Trojanowska, Jacek Stepniewski, Jozef Dulak Cells.2019; 8(11): 1440. CrossRef - Diabetic Retinopathy–An Underdiagnosed and Undertreated Inflammatory, Neuro-Vascular Complication of Diabetes
Stephen H. Sinclair, Stanley S. Schwartz Frontiers in Endocrinology.2019;[Epub] CrossRef - Identification of Diagnostic and Prognostic microRNAs for Recurrent Vitreous Hemorrhage in Patients with Proliferative Diabetic Retinopathy
Parviz Mammadzada, Juliette Bayle, Johann Gudmundsson, Anders Kvanta, Helder André Journal of Clinical Medicine.2019; 8(12): 2217. CrossRef - RANKL blockade suppresses pathological angiogenesis and vascular leakage in ischemic retinopathy
Sangmi Ock, Soyoung Park, Junyeop Lee, Jaetaek Kim Biochemical and Biophysical Research Communications.2019; 516(2): 350. CrossRef - EndogenousClostridium perfringensPanophthalmitis with Potential Entry Port from Diverticulitis Exacerbated by Proliferative Diabetic Retinopathy
Vamsee Neerukonda, Anny M. S. Cheng, Swetha Dhanireddy, Samuel Alpert, Han Y. Yin Case Reports in Ophthalmological Medicine.2019; 2019: 1. CrossRef - Attenuation of Retinal Endothelial Vasodilator Function in a Rat Model of Retinopathy of Prematurity
Ayuki Nakano, Asami Mori, Shiho Arima, Daiki Asano, Akane Morita, Kenji Sakamoto, Tohru Nagamitsu, Tsutomu Nakahara Current Eye Research.2019; 44(12): 1360. CrossRef - Efficacy of fenofibrate for diabetic retinopathy
Xing-jie Su, Lin Han, Yan-Xiu Qi, Hong-wei Liu Medicine.2019; 98(14): e14999. CrossRef - Nutraceuticals for the Treatment of Diabetic Retinopathy
Maria Grazia Rossino, Giovanni Casini Nutrients.2019; 11(4): 771. CrossRef - Efficacy of ranibizumab for the treatment of diabetic retinopathy
Yong-bo Ren, Xing-jie Su, Yan-xiu Qi, He-qun Luan, Qi Sun Medicine.2019; 98(17): e15409. CrossRef
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