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Se Hwan Park  (Park SH) 1 Article
Cardiovascular Risk Assessment with Vascular Function, Carotid Atherosclerosis and the UKPDS Risk Engine in Korean Patients with Newly Diagnosed Type 2 Diabetes
Choon Sik Seon, Kyung Wan Min, Seung Yup Lee, Kyoung Woo Nho, Se Hwan Park, Bo Kyung Koo, Kyung Ah Han
Diabetes Metab J. 2011;35(6):619-627.   Published online December 26, 2011
DOI: https://doi.org/10.4093/dmj.2011.35.6.619
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  • 10 Crossref
AbstractAbstract PDFPubReader   
Background

Patients with type 2 diabetes have an increased risk of cardiovascular disease. Few studies have evaluated the cardiovascular disease (CVD) risk simultaneously using the United Kingdom Prospective Diabetes Study (UKPDS) risk engine and non-invasive vascular tests in patients with newly diagnosed type 2 diabetes.

Methods

Participants (n=380; aged 20 to 81 years) with newly diagnosed type 2 diabetes were free of clinical evidence of CVD. The 10-year coronary heart disease (CHD) and stroke risks were calculated for each patient using the UKPDS risk engine. Carotid intima media thickness (CIMT), flow mediated dilation (FMD), pulse wave velocity (PWV) and augmentation index (AI) were measured. The correlations between the UKPDS risk engine and the non-invasive vascular tests were assessed using partial correlation analysis, after adjusting for age, and multiple regression analysis.

Results

The mean 10-year CHD and 10-year stroke risks were 14.92±11.53% and 4.03±3.95%, respectively. The 10-year CHD risk correlated with CIMT (P<0.001), FMD (P=0.017), and PWV (P=0.35) after adjusting for age. The 10-year stroke risk correlated only with the mean CIMT (P<0.001) after adjusting for age. FMD correlated with age (P<0.01) and systolic blood pressure (P=0.09). CIMT correlated with age (P<0.01), HbA1c (P=0.05), and gender (P<0.01).

Conclusion

The CVD risk is increased at the onset of type 2 diabetes. CIMT, FMD, and PWV along with the UKPDS risk engine should be considered to evaluate cardiovascular disease risk in patients with newly diagnosed type 2 diabetes.

Citations

Citations to this article as recorded by  
  • Association of cardiovascular risk estimate with degree of atherosclerosis in patients with type 2 diabetes mellitus
    Mashkura Riyazuddeen, AliHasan Faiz Karnam, L Gopinath, Nayyar Iqbal
    Journal of Current Research in Scientific Medicine.2019; 5(2): 94.     CrossRef
  • Carotid atherosclerosis and its relationship to coronary heart disease and stroke risk in patients with type 2 diabetes mellitus
    Yan Wu, Jie He, Xue Sun, Yi-Ming Zhao, Han-Yu Lou, Xiao-li Ji, Xiao-Hong Pang, Li-Zhen Shan, Ying-Xiu Kang, Jun Xu, Song-Zhao Zhang, Yong-Jian Wang, Yue-Zhong Ren, Peng-Fei Shan
    Medicine.2017; 96(39): e8151.     CrossRef
  • Diabetes Associated to Atherosclerosis Risk Factors in Patients of Family Health Unity
    Polyane Medeiros Alves, Raiane dos Santos Pereira, Ariel Gustavo Letti, Álvaro Luís Müller da Fonseca
    Open Journal of Preventive Medicine.2015; 05(04): 177.     CrossRef
  • Independent Association of Circulating Level of Chemerin With Functional and Early Morphological Vascular Changes in Newly Diagnosed Type 2 Diabetic Patients
    Bin Lu, Ming Zhao, Weimin Jiang, Jian Ma, Cuihua Yang, Jiaqing Shao, Ping Gu
    Medicine.2015; 94(47): e1990.     CrossRef
  • Assessment of Cardiovascular Risk in Adults With Type 2 Diabetes and Metabolic Syndrome
    Chun-Ja Kim, Hee Sun Kang, Elizabeth A. Schlenk, Sun-Mi Chae
    The Diabetes Educator.2015; 41(2): 203.     CrossRef
  • Urinary adiponectin concentration is positively associated with micro- and macro-vascular complications
    Won Seon Jeon, Ji Woo Park, Namseok Lee, Se Eun Park, Eun Jung Rhee, Won Young Lee, Ki Won Oh, Sung Woo Park, Cheol-Young Park, Byung-Soo Youn
    Cardiovascular Diabetology.2013;[Epub]     CrossRef
  • Development and a Pilot Test of an Internet-Based Cardiovascular Risk Reduction Program for Korean Male Workers With Metabolic Syndrome
    CHUN-JA KIM, SEWON KANG
    CIN: Computers, Informatics, Nursing.2013; 31(4): 157.     CrossRef
  • Risk Factors for the Progression of Intima-Media Thickness of Carotid Arteries: A 2-Year Follow-Up Study in Patients with Newly Diagnosed Type 2 Diabetes
    Sang Ouk Chin, Jin Kyung Hwang, Sang Youl Rhee, Suk Chon, You-Cheol Hwang, Seungjoon Oh, Kyu Jeung Ahn, Ho Yeon Chung, Jeong-taek Woo, Sung-Woon Kim, Young Seol Kim, Ja-Heon Kang, In-Kyung Jeong
    Diabetes & Metabolism Journal.2013; 37(5): 365.     CrossRef
  • Epicardial adipose tissue thickness is an indicator for coronary artery stenosis in asymptomatic type 2 diabetic patients: its assessment by cardiac magnetic resonance
    Hyun Kim, Kwang Kim, Hye-Jeong Lee, Hee Yu, Jae Moon, Eun Kang, Bong Cha, Hyun Lee, Byung-Wan Lee, Young Kim
    Cardiovascular Diabetology.2012; 11(1): 83.     CrossRef
  • Potential association between coronary artery disease and the inflammatory biomarker YKL-40 in asymptomatic patients with type 2 diabetes mellitus
    Hyun Min Kim, Byung-Wan Lee, Young-Mi Song, Won Jin Kim, Hyuk-Jae Chang, Dong-Hoon Choi, Hee Tae Yu, EunSeok Kang, Bong Soo Cha, Hyun Chul Lee
    Cardiovascular Diabetology.2012;[Epub]     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal