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Sangkyu Park  (Park S) 2 Articles
Obesity and Metabolic Syndrome
Inhibition of Serotonin Synthesis Induces Negative Hepatic Lipid Balance
Jun Namkung, Ko Eun Shong, Hyeongseok Kim, Chang-Myung Oh, Sangkyu Park, Hail Kim
Diabetes Metab J. 2018;42(3):233-243.   Published online April 25, 2018
  • 4,822 View
  • 87 Download
  • 24 Web of Science
  • 22 Crossref
AbstractAbstract PDFPubReader   

Hepatic steatosis is caused by metabolic stress associated with a positive lipid balance, such as insulin resistance and obesity. Previously we have shown the anti-obesity effects of inhibiting serotonin synthesis, which eventually improved insulin sensitivity and hepatic steatosis. However, it is not clear whether serotonin has direct effect on hepatic lipid accumulation. Here, we showed the possibility of direct action of serotonin on hepatic steatosis.


Mice were treated with para-chlorophenylalanine (PCPA) or LP-533401 to inhibit serotonin synthesis and fed with high fat diet (HFD) or high carbohydrate diet (HCD) to induce hepatic steatosis. Hepatic triglyceride content and gene expression profiles were analyzed.


Pharmacological and genetic inhibition of serotonin synthesis reduced HFD-induced hepatic lipid accumulation. Furthermore, short-term PCPA treatment prevented HCD-induced hepatic steatosis without affecting glucose tolerance and browning of subcutaneous adipose tissue. Gene expression analysis revealed that the expressions of genes involved in de novo lipogenesis and triacylglycerol synthesis were downregulated by short-term PCPA treatment as well as long-term PCPA treatment.


Short-term inhibition of serotonin synthesis prevented hepatic lipid accumulation without affecting systemic insulin sensitivity and energy expenditure, suggesting the direct steatogenic effect of serotonin in liver.


Citations to this article as recorded by  
  • A new serotonin 2A receptor antagonist with potential benefits in Non-Alcoholic Fatty Liver Disease
    Lucia Sessa, Simona Concilio, Jesús Fominaya, Daniela Eletto, Stefano Piotto, Xavier Busquets
    Life Sciences.2023; 314: 121315.     CrossRef
  • Serotonin reuptake transporter deficiency promotes liver steatosis and impairs intestinal barrier function in obese mice fed a Western‐style diet
    Louisa Filipe Rosa, Eva Haasis, Annkathrin Knauss, Daria Guseva, Stephan C. Bischoff
    Neurogastroenterology & Motility.2023;[Epub]     CrossRef
  • Probiotics counteract hepatic steatosis caused by ketogenic diet and upregulate AMPK signaling in a model of infantile epilepsy
    Chunlong Mu, Naghmeh Nikpoor, Thomas A. Tompkins, Jong M. Rho, Morris H. Scantlebury, Jane Shearer
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  • Research Progresses for 5-Hydroxytryptamine in Lipid Metabolism
    钰婷 吴
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    Hang Yin, Anhua Shi, Junzi Wu
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  • Involvement of the liver-gut peripheral neural axis in nonalcoholic fatty liver disease pathologies via hepatic HTR2A
    Takashi Owaki, Kenya Kamimura, Masayoshi Ko, Itsuo Nagayama, Takuro Nagoya, Osamu Shibata, Chiyumi Oda, Shinichi Morita, Atsushi Kimura, Takeki Sato, Toru Setsu, Akira Sakamaki, Hiroteru Kamimura, Takeshi Yokoo, Shuji Terai
    Disease Models & Mechanisms.2022;[Epub]     CrossRef
  • Pancreatic Sirtuin 3 Deficiency Promotes Hepatic Steatosis by Enhancing 5-Hydroxytryptamine Synthesis in Mice With Diet-Induced Obesity
    Xing Ming, Arthur C.K. Chung, Dandan Mao, Huanyi Cao, Baoqi Fan, Willy K.K. Wong, Chin Chung Ho, Heung Man Lee, Kristina Schoonjans, Johan Auwerx, Guy A. Rutter, Juliana C.N. Chan, Xiao Yu Tian, Alice P.S. Kong
    Diabetes.2021; 70(1): 119.     CrossRef
  • Peripheral Selective Oxadiazolylphenyl Alanine Derivatives as Tryptophan Hydroxylase 1 Inhibitors for Obesity and Fatty Liver Disease
    Eun Jung Bae, Won Gun Choi, Haushabhau S. Pagire, Suvarna H. Pagire, Saravanan Parameswaran, Jun-Ho Choi, Jihyeon Yoon, Won-il Choi, Ji Hun Lee, Jin Sook Song, Myung Ae Bae, Mijin Kim, Jae-Han Jeon, In-Kyu Lee, Hail Kim, Jin Hee Ahn
    Journal of Medicinal Chemistry.2021; 64(2): 1037.     CrossRef
  • Modulation of serotonin in the gut-liver neural axis ameliorates the fatty and fibrotic changes in non-alcoholic fatty liver
    Masayoshi Ko, Kenya Kamimura, Takashi Owaki, Takuro Nagoya, Norihiro Sakai, Itsuo Nagayama, Yusuke Niwa, Osamu Shibata, Chiyumi Oda, Shinichi Morita, Atsushi Kimura, Ryosuke Inoue, Toru Setsu, Akira Sakamaki, Takeshi Yokoo, Shuji Terai
    Disease Models & Mechanisms.2021;[Epub]     CrossRef
  • Metabolic Disturbances in Rat Sublines with Constitutionally Altered Serotonin Homeostasis
    Maja Kesić, Petra Baković, Ranko Stojković, Jasminka Štefulj, Lipa Čičin-Šain
    International Journal of Molecular Sciences.2021; 22(10): 5400.     CrossRef
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    Yu-Xin Zhang, Chen Li, Xiu-Rui Liang, Jia-Qi Jin, Yi Zhang, Fan Xu, Jing Guan, Ying-Ying Ma, Xiao-Nan Ma, Run-Kun Liu, Ji-Hua Fu
    European Journal of Pharmacology.2021; 908: 174355.     CrossRef
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    Ahmed Ayyash, Alison C. Holloway
    Canadian Journal of Physiology and Pharmacology.2021; 99(9): 983.     CrossRef
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    Eleni Rebelos, Patricia Iozzo, Maria Angela Guzzardi, Maurizia Rossana Brunetto, Ferruccio Bonino
    World Journal of Gastroenterology.2021; 27(30): 4999.     CrossRef
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    Won Gun Choi, Wonsuk Choi, Tae Jung Oh, Hye-Na Cha, Inseon Hwang, Yun Kyung Lee, Seung Yeon Lee, Hyemi Shin, Ajin Lim, Dongryeol Ryu, Jae Myoung Suh, So-Young Park, Sung Hee Choi, Hail Kim
    Journal of Clinical Investigation.2021;[Epub]     CrossRef
  • Green tea and selenium-enriched green tea ameliorates non-alcoholic fatty liver disease through peripheral 5-hydroxytryptamine signals in high-fat diet-fed mice
    Lin Zhang, Jia-Ying Xu, Ya-Fang Du, Zhang-Min Wang, Jian-Xiang Li, N. Ou-Yang, Yan Wang, Xue-Bin Yin, Li-Qiang Qin
    International Food Research Journal.2021; 28(5): 996.     CrossRef
  • Inhibition of serotonin synthesis: A novel therapeutic paradigm
    Michael Bader
    Pharmacology & Therapeutics.2020; 205: 107423.     CrossRef
  • One-Carbon Metabolism in Fatty Liver Disease and Fibrosis: One-Carbon to Rule Them All
    da Silva Robin P, Eudy Brandon J, Deminice Rafael
    The Journal of Nutrition.2020; 150(5): 994.     CrossRef
  • Design, Synthesis, and Biological Evaluation of New Peripheral 5HT2A Antagonists for Nonalcoholic Fatty Liver Disease
    Minhee Kim, Inseon Hwang, Haushabhau S. Pagire, Suvarna H. Pagire, Wonsuk Choi, Won Gun Choi, Jihyeon Yoon, Won Mi Lee, Jin Sook Song, Eun Kyung Yoo, Seung Mi Lee, Mi-jin Kim, Myung Ae Bae, Dooseop Kim, Heejong Lee, Eun-Young Lee, Jae-Han Jeon, In-Kyu Lee
    Journal of Medicinal Chemistry.2020; 63(8): 4171.     CrossRef
  • Hepatic fibrosis is associated with total proteinuria in Korean patients with type 2 diabetes
    Eugene Han, Yongin Cho, Kyung-won Kim, Yong-ho Lee, Eun Seok Kang, Bong-Soo Cha, Byung-wan Lee
    Medicine.2020; 99(33): e21038.     CrossRef
  • The Role of the Gut Microbiota in Lipid and Lipoprotein Metabolism
    Yijing Yu, Fitore Raka, Khosrow Adeli
    Journal of Clinical Medicine.2019; 8(12): 2227.     CrossRef
  • Emerging Roles for Serotonin in Regulating Metabolism: New Implications for an Ancient Molecule
    Julian M Yabut, Justin D Crane, Alexander E Green, Damien J Keating, Waliul I Khan, Gregory R Steinberg
    Endocrine Reviews.2019; 40(4): 1092.     CrossRef
  • Serotonin signals through a gut-liver axis to regulate hepatic steatosis
    Wonsuk Choi, Jun Namkung, Inseon Hwang, Hyeongseok Kim, Ajin Lim, Hye Jung Park, Hye Won Lee, Kwang-Hyub Han, Seongyeol Park, Ji-Seon Jeong, Geul Bang, Young Hwan Kim, Vijay K. Yadav, Gerard Karsenty, Young Seok Ju, Chan Choi, Jae Myoung Suh, Jun Yong Par
    Nature Communications.2018;[Epub]     CrossRef
Obesity and Metabolic Syndrome
Serotonin as a New Therapeutic Target for Diabetes Mellitus and Obesity
Chang-Myung Oh, Sangkyu Park, Hail Kim
Diabetes Metab J. 2016;40(2):89-98.   Published online March 27, 2016
  • 7,139 View
  • 162 Download
  • 68 Web of Science
  • 73 Crossref
AbstractAbstract PDFPubReader   

Serotonin (5-hydroxytryptamine [5-HT]) is a monoamine that has various functions in both neuronal and non-neuronal systems. In the central nervous system, 5-HT regulates mood and feeding behaviors as a neurotransmitter. Thus, there have been many trials aimed at increasing the activity of 5-HT in the central nervous system, and some of the developed methods are already used in the clinical setting as anti-obesity drugs. Unfortunately, some drugs were withdrawn due to the development of unwanted peripheral side effects, such as valvular heart disease and pulmonary hypertension. Recent studies revealed that peripheral 5-HT plays an important role in metabolic regulation in peripheral tissues, where it suppresses adaptive thermogenesis in brown adipose tissue. Inhibition of 5-HT synthesis reduced the weight gain and improved the metabolic dysfunction in a diet-induced obesity mouse model. Genome-wide association studies also revealed genetic associations between the serotonergic system and obesity. Several genetic polymorphisms in tryptophan hydroxylase and 5-HT receptors were shown to have strong associations with obesity. These results support the clinical significance of the peripheral serotonergic system as a therapeutic target for obesity and diabetes.


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    Journal of Neuroendocrinology.2018;[Epub]     CrossRef
  • Calcium channel blockers as drug repurposing candidates for gestational diabetes: Mining large scale genomic and electronic health records data to repurpose medications
    Jeffery A. Goldstein, Lisa A. Bastarache, Joshua C. Denny, Dan M. Roden, Jill M. Pulley, David M. Aronoff
    Pharmacological Research.2018; 130: 44.     CrossRef
  • Quantitative profiling of neurotransmitter abnormalities in brain, cerebrospinal fluid, and serum of experimental diabetic encephalopathy male rat
    Xiaowen Han, Mengjun Min, Juan Wang, Zejun Bao, Hongbin Fan, Xinyu Li, Temitope Isaac Adelusi, Xueyan Zhou, Xiaoxing Yin
    Journal of Neuroscience Research.2018; 96(1): 138.     CrossRef
  • A randomized controlled trial of lorcaserin and lifestyle counselling for weight loss maintenance: changes in emotion‐ and stress‐related eating, food cravings and appetite
    A. M. Chao, T. A. Wadden, R. L. Pearl, N. Alamuddin, S. M. Leonard, Z. M. Bakizada, E. Pinkasavage, K. A. Gruber, O. A. Walsh, R. I. Berkowitz, N. Alfaris, J. S. Tronieri
    Clinical Obesity.2018; 8(6): 383.     CrossRef
  • Lorcaserin and metabolic disease: weight‐loss dependent and independent effects
    H. Bays, C. Perdomo, E. Nikonova, R. Knoth, M. Malhotra
    Obesity Science & Practice.2018; 4(6): 499.     CrossRef
  • Rol del sistema serotoninérgico en la diabetes mellitus y sus dianas farmacológicas
    Victor Orozco, Camilo Caicedo
    Revista Médica Sanitas.2018; 21(3): 125.     CrossRef
  • Effects of Melatonin Administration in Different Time Modes on Morphofunctional Indices of the Hypothalamic Serotonergic Neurons in Obese Rats
    O. O. Kalmukova, A. V. Yurchenko, V. M. Kyryk, V. M. Nepomnyaschy, O. M. Savchuk, M. E. Dzerzhynsky
    Neurophysiology.2018; 50(6): 398.     CrossRef
  • Role of central and peripheral serotonin in obesity: what to expect in the near pharmacotherapy future?
    Mina T Kelleni
    Advances in Obesity, Weight Management & Control.2018;[Epub]     CrossRef
  • Elevating serotonin pre-partum alters the Holstein dairy cow hepatic adaptation to lactation
    Samantha R. Weaver, Allan S. Prichard, Noah L. Maerz, Austin P. Prichard, Elizabeth L. Endres, Lorenzo E. Hernández-Castellano, Matthew S. Akins, Rupert M. Bruckmaier, Laura L. Hernandez, Juan J. Loor
    PLOS ONE.2017; 12(9): e0184939.     CrossRef
  • Biology of obesity and weight regain
    Mary Madeline Rogge, Bibha Gautam
    Journal of the American Association of Nurse Practitioners.2017; 29(S1): S15.     CrossRef
  • 5-HT 2A receptor deficiency alters the metabolic and transcriptional, but not the behavioral, consequences of chronic unpredictable stress
    Minal Jaggar, Noelia Weisstaub, Jay A. Gingrich, Vidita A. Vaidya
    Neurobiology of Stress.2017; 7: 89.     CrossRef
  • Serotonergic Control of Metabolic Homeostasis
    Steven C. Wyler, Caleb C. Lord, Syann Lee, Joel K. Elmquist, Chen Liu
    Frontiers in Cellular Neuroscience.2017;[Epub]     CrossRef
  • Serotonin and Its Receptor as a New Antioxidant Therapeutic Target for Diabetic Kidney Disease
    Yu Yang, Hui Huang, Zheng Xu, Jun-kai Duan
    Journal of Diabetes Research.2017; 2017: 1.     CrossRef
  • Bivalent role of intra-platelet serotonin in liver regeneration and tumor recurrence in humans
    Robin Padickakudy, David Pereyra, Florian Offensperger, Philipp Jonas, Lukas Oehlberger, Christian Schwarz, Stefanie Haegele, Alice Assinger, Christine Brostjan, Thomas Gruenberger, Patrick Starlinger
    Journal of Hepatology.2017; 67(6): 1243.     CrossRef
  • Factors involved in white‐to‐brown adipose tissue conversion and in thermogenesis: a review
    T. Montanari, N. Pošćić, M. Colitti
    Obesity Reviews.2017; 18(5): 495.     CrossRef
  • Cross-Talk Between Insulin Signaling and G Protein–Coupled Receptors
    Qin Fu, Qian Shi, Toni M. West, Yang K. Xiang
    Journal of Cardiovascular Pharmacology.2017; 70(2): 74.     CrossRef
  • P62 plasmid can alleviate diet-induced obesity and metabolic dysfunctions
    Tatiana Halenova, Oleksii Savchuk, Ludmila Ostapchenko, Andrey Chursov, Nathan Fridlyand, Andrey B. Komissarov, Franco Venanzi, Sergey I. Kolesnikov, Albert A. Sufianov, Michael Y. Sherman, Vladimir L. Gabai, Alexander M. Shneider
    Oncotarget.2017; 8(34): 56030.     CrossRef
  • Regulation of Systemic Energy Homeostasis by Peripheral Serotonin
    Jun Namkung, Chang-Myung Oh, Sangkyu Park, Hail Kim
    Journal of mucopolysaccharidosis and rare disease.2016; 2(2): 43.     CrossRef
  • Human Beta Cells Produce and Release Serotonin to Inhibit Glucagon Secretion from Alpha Cells
    Joana Almaça, Judith Molina, Danusa Menegaz, Alexey N. Pronin, Alejandro Tamayo, Vladlen Slepak, Per-Olof Berggren, Alejandro Caicedo
    Cell Reports.2016; 17(12): 3281.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal