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Qiuyue Hu  (Hu Q) 2 Articles
MondoA Is Required for Normal Myogenesis and Regulation of the Skeletal Muscle Glycogen Content in Mice
Hui Ran, Yao Lu, Qi Zhang, Qiuyue Hu, Junmei Zhao, Kai Wang, Xuemei Tong, Qing Su
Diabetes Metab J. 2021;45(5):797-797.   Published online September 30, 2021
DOI: https://doi.org/10.4093/dmj.2021.0251
Corrects: Diabetes Metab J 2021;45(3):439
  • 2,837 View
  • 79 Download
  • 4 Web of Science
  • 4 Crossref
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Citations

Citations to this article as recorded by  
  • Attenuated glucose uptake promotes catabolic metabolism through activated AMPK signaling and impaired insulin signaling in zebrafish
    Longwei Xi, Gang Zhai, Yulong Liu, Yulong Gong, Qisheng Lu, Zhimin Zhang, Haokun Liu, Junyan Jin, Xiaoming Zhu, Zhan Yin, Shouqi Xie, Dong Han
    Frontiers in Nutrition.2023;[Epub]     CrossRef
  • Glucose-induced and ChREBP: MLX-mediated lipogenic program promotes hepatocellular carcinoma development
    Aijuan Yu, Pengcheng Yu, Yuwen Zhu, Rui Zhu, Renqiang Sun, Dan Ye, Fa-Xing Yu
    Oncogene.2023; 42(43): 3182.     CrossRef
  • Regulation of Normal and Neoplastic Proliferation and Metabolism by the Extended Myc Network
    Edward V. Prochownik
    Cells.2022; 11(24): 3974.     CrossRef
  • The Roles of Carbohydrate Response Element Binding Protein in the Relationship between Carbohydrate Intake and Diseases
    Katsumi Iizuka
    International Journal of Molecular Sciences.2021; 22(21): 12058.     CrossRef
Basic Research
MondoA Is Required for Normal Myogenesis and Regulation of the Skeletal Muscle Glycogen Content in Mice
Hui Ran, Yao Lu, Qi Zhang, Qiuyue Hu, Junmei Zhao, Kai Wang, Xuemei Tong, Qing Su
Diabetes Metab J. 2021;45(3):439-451.   Published online May 18, 2020
DOI: https://doi.org/10.4093/dmj.2019.0212
Correction in: Diabetes Metab J 2021;45(5):797
  • 6,128 View
  • 191 Download
  • 4 Web of Science
  • 3 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background

Skeletal muscle is the largest tissue in the human body, and it plays a major role in exerting force and maintaining metabolism homeostasis. The role of muscle transcription factors in the regulation of metabolism is not fully understood. MondoA is a glucose-sensing transcription factor that is highly expressed in skeletal muscle. Previous studies suggest that MondoA can influence systemic metabolism homeostasis. However, the function of MondoA in the skeletal muscle remains unclear.

Methods

We generated muscle-specific MondoA knockout (MAKO) mice and analyzed the skeletal muscle morphology and glycogen content. Along with skeletal muscle from MAKO mice, C2C12 myocytes transfected with small interfering RNA against MondoA were also used to investigate the role and potential mechanism of MondoA in the development and glycogen metabolism of skeletal muscle.

Results

MAKO caused muscle fiber atrophy, reduced the proportion of type II fibers compared to type I fibers, and increased the muscle glycogen level. MondoA knockdown inhibited myoblast proliferation, migration, and differentiation by inhibiting the phosphatase and tensin homolog (PTEN)/phosphoinositide 3-kinase (PI3K)/Akt pathway. Further mechanistic experiments revealed that the increased muscle glycogen in MAKO mice was caused by thioredoxin-interacting protein (TXNIP) downregulation, which led to upregulation of glucose transporter 4 (GLUT4), potentially increasing glucose uptake.

Conclusion

MondoA appears to mediate mouse myofiber development, and MondoA decreases the muscle glycogen level. The findings indicate the potential function of MondoA in skeletal muscle, linking the glucose-related transcription factor to myogenesis and skeletal myofiber glycogen metabolism.

Citations

Citations to this article as recorded by  
  • The Function of MondoA and ChREBP Nutrient—Sensing Factors in Metabolic Disease
    Byungyong Ahn
    International Journal of Molecular Sciences.2023; 24(10): 8811.     CrossRef
  • Normal and Neoplastic Growth Suppression by the Extended Myc Network
    Edward V. Prochownik, Huabo Wang
    Cells.2022; 11(4): 747.     CrossRef
  • The Role of Mondo Family Transcription Factors in Nutrient-Sensing and Obesity
    Huiyi Ke, Yu Luan, Siming Wu, Yemin Zhu, Xuemei Tong
    Frontiers in Endocrinology.2021;[Epub]     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal