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Pedro Parra  (Parra P) 1 Article
A Cross-Sectional Study of the Phenotypes of Obesity and Insulin Resistance in Adults with Down Syndrome
Diego Real de Asua, Pedro Parra, Ramón Costa, Fernando Moldenhauer, Carmen Suarez
Diabetes Metab J. 2014;38(6):464-471.   Published online December 15, 2014
DOI: https://doi.org/10.4093/dmj.2014.38.6.464
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  • 24 Web of Science
  • 24 Crossref
AbstractAbstract PDFPubReader   
Background

Despite the confluence of multiple cardiovascular risk factors, subclinical atherosclerotic damage and cardiovascular events remain extremely rare in adults with Down syndrome (DS). We aim to determine the prevalence of obesity and metabolic disorders in an adult cohort with DS and to compare our findings with adults without DS.

Methods

Cross-sectional study of 51 consecutively selected adults with DS living in the community and 51 healthy controls in an outpatient clinic of a tertiary care hospital in Madrid, Spain. Epidemiological data (age and gender), anthropometric data (body mass index and waist-to-height ratio), coexisting clinical conditions, and laboratory data (fasting glucose, insulin, glycated hemoglobin, creatinine, thyroid hormones, vitamins, and lipid profile) were measured and compared between the groups.

Results

Adults with DS were significantly younger and more often men with a higher prevalence of overweight and obesity than controls. Their waist-to-height ratio was higher, and they more frequently had abdominal obesity. The results of an analysis adjusted for age and gender revealed no differences in fasting insulin levels, homeostatic model assessment indexes, or lipid profile between adults with DS and controls.

Conclusion

Adults with DS presented a high prevalence of overweight and obesity. However, we found no differences in lipid profile, prevalence of insulin resistance, or metabolic syndrome between adults with DS and controls.

Citations

Citations to this article as recorded by  
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    BMC Public Health.2024;[Epub]     CrossRef
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    American Journal of Medical Genetics Part A.2020; 182(7): 1832.     CrossRef
  • Adults with Down syndrome challenge another paradigm: When aging no longer entails arterial hypertension
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    Journal of Intellectual Disability Research.2020; 64(10): 804.     CrossRef
  • Evaluation of biochemical and hematological parameters in adults with Down syndrome
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    E. A. Pitchford, R. E. Hasson, J. E. Hornyak, J. C. Lumeng, K. E. Peterson, D. A. Ulrich
    Journal of Intellectual Disability Research.2019; 63(12): 1401.     CrossRef
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  • Acanthosis nigricans and the metabolic syndrome
    Ayse Serap Karadağ, Yi You, Retno Danarti, Safaa Al-Khuzaei, WenChieh Chen
    Clinics in Dermatology.2018; 36(1): 48.     CrossRef
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    American Journal of Medical Genetics Part A.2018; 176(1): 116.     CrossRef
  • Recomendaciones para la atención a los adultos con síndrome de Down. Revisión de la literatura
    M. González-Cerrajero, M. Quero-Escalada, F. Moldenhauer, C. Suárez Fernández
    Medicina de Familia. SEMERGEN.2018; 44(5): 342.     CrossRef
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