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Nicolas Cherbuin 2 Articles
Complication
Association between Type 2 Diabetes Mellitus and Brain Atrophy: A Meta-Analysis
Tianqi Zhang, Marnie Shaw, Nicolas Cherbuin
Diabetes Metab J. 2022;46(5):781-802.   Published online March 8, 2022
DOI: https://doi.org/10.4093/dmj.2021.0189
  • 7,867 View
  • 311 Download
  • 16 Web of Science
  • 25 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
Type 2 diabetes mellitus (T2DM) is known to be associated with cognitive decline and brain structural changes. This study systematically reviews and estimates human brain volumetric differences and atrophy associated with T2DM.
Methods
PubMed, PsycInfo and Cochrane Library were searched for brain imaging studies reporting on brain volume differences between individuals with T2DM and healthy controls. Data were examined using meta-analysis, and association between age, sex, diabetes characteristics and brain volumes were tested using meta-regression.
Results
A total of 14,605 entries were identified; after title, abstract and full-text screening applying inclusion and exclusion criteria, 64 studies were included and 42 studies with compatible data contributed to the meta-analysis (n=31,630; mean age 71.0 years; 44.4% male; 26,942 control; 4,688 diabetes). Individuals with T2DM had significantly smaller total brain volume, total grey matter volume, total white matter volume and hippocampal volume (approximately 1% to 4%); meta-analyses of smaller samples focusing on other brain regions and brain atrophy rate in longitudinal investigations also indicated smaller brain volumes and greater brain atrophy associated with T2DM. Meta-regression suggests that diabetes-related brain volume differences start occurring in early adulthood, decreases with age and increases with diabetes duration.
Conclusion
T2DM is associated with smaller total and regional brain volume and greater atrophy over time. These effects are substantial and highlight an urgent need to develop interventions to reduce the risk of T2DM for brain health.

Citations

Citations to this article as recorded by  
  • The psychological basis of hunger and its dysfunctions
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    Nutrition Reviews.2024; 82(10): 1444.     CrossRef
  • Diabetes, antidiabetic medications and risk of dementia: A systematic umbrella review and meta‐analysis
    Alvin Kuate Defo, Veselko Bakula, Alessandro Pisaturo, Christopher Labos, Simon S. Wing, Stella S. Daskalopoulou
    Diabetes, Obesity and Metabolism.2024; 26(2): 441.     CrossRef
  • Cognitive deficits among people with schizophrenia and prediabetes or diabetes
    Alexander Panickacheril John, Thynn Mya, Darren Haywood
    Acta Psychiatrica Scandinavica.2024; 149(1): 65.     CrossRef
  • The association of glucose metabolism measures and diabetes status with Alzheimer’s disease biomarkers of amyloid and tau: A systematic review and meta-analysis
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    Neuroscience & Biobehavioral Reviews.2024; 159: 105604.     CrossRef
  • ECHDC3 Variant Regulates the Right Hippocampal Microstructural Integrity and Verbal Memory in Type 2 Diabetes Mellitus
    Qiyu Zhao, Xin Du, Feng Liu, Yang Zhang, Wen Qin, Quan Zhang
    Neuroscience.2024; 538: 30.     CrossRef
  • The hemodynamic response function as a type 2 diabetes biomarker: a data-driven approach
    Pedro Guimarães, Pedro Serranho, João V. Duarte, Joana Crisóstomo, Carolina Moreno, Leonor Gomes, Rui Bernardes, Miguel Castelo-Branco
    Frontiers in Neuroinformatics.2024;[Epub]     CrossRef
  • What have clinical trials taught us about brain health?
    Keon-Joo Lee, Hee-Joon Bae
    Cerebral Circulation - Cognition and Behavior.2024; 6: 100199.     CrossRef
  • Understanding the relationship between type-2 diabetes, MRI markers of neurodegeneration and small vessel disease, and dementia risk: a mediation analysis
    Leslie Grasset, Eric Frison, Catherine Helmer, Gwénaëlle Catheline, Geneviève Chêne, Carole Dufouil
    European Journal of Epidemiology.2024; 39(4): 409.     CrossRef
  • Vulnerability of the Hippocampus to Insults: Links to Blood–Brain Barrier Dysfunction
    Terry L. Davidson, Richard J. Stevenson
    International Journal of Molecular Sciences.2024; 25(4): 1991.     CrossRef
  • Diabetes mellitus in older persons with neurocognitive disorder: overtreatment prevalence and associated structural brain MRI findings
    Pauline Putallaz, Laurence Seematter-Bagnoud, Bogdan Draganski, Olivier Rouaud, Hélène Krief, Christophe J. Büla
    BMC Geriatrics.2024;[Epub]     CrossRef
  • Accelerometer‐Measured Behavior Patterns in Incident Cerebrovascular Disease: Insights for Preventative Monitoring From the UK Biobank
    Stephanie J. Zawada, Ali Ganjizadeh, Gian Marco Conte, Bart M. Demaerschalk, Bradley J. Erickson
    Journal of the American Heart Association.2024;[Epub]     CrossRef
  • Effects of glycaemic control on memory performance, hippocampal volumes and depressive symptomology
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    Diabetology & Metabolic Syndrome.2024;[Epub]     CrossRef
  • The effect of diabetes in the multifaceted relationship between education and cognitive function
    Constantin Reinke
    BMC Public Health.2024;[Epub]     CrossRef
  • Analysis of Brain Age Gap across Subject Cohorts and Prediction Model Architectures
    Lara Dular, Žiga Špiclin
    Biomedicines.2024; 12(9): 2139.     CrossRef
  • The gut microbiota‐astrocyte axis: Implications for type 2 diabetic cognitive dysfunction
    Zi‐Han Li, Ya‐Yi Jiang, Cai‐Yi Long, Qian Peng, Ren‐Song Yue
    CNS Neuroscience & Therapeutics.2023; 29(S1): 59.     CrossRef
  • NHANES 2011–2014 Reveals Decreased Cognitive Performance in U.S. Older Adults with Metabolic Syndrome Combinations
    Edgar Díaz-Camargo, Juan Hernández-Lalinde, María Sánchez-Rubio, Yudy Chaparro-Suárez, Liseth Álvarez-Caicedo, Alexandra Fierro-Zarate, Marbel Gravini-Donado, Henry García-Pacheco, Joselyn Rojas-Quintero, Valmore Bermúdez
    International Journal of Environmental Research and Public Health.2023; 20(7): 5257.     CrossRef
  • People with Diabetes Have Poorer Self-Rated Health (SRH) and Diabetes Moderates the Association between Age and SRH
    Weixi Kang, Antonio Malvaso
    Diseases.2023; 11(2): 73.     CrossRef
  • Cognitive dysfunction in diabetes: abnormal glucose metabolic regulation in the brain
    Shan Zhang, Yueying Zhang, Zhige Wen, YaNan Yang, Tianjie Bu, Xiangwei Bu, Qing Ni
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Associations of Glucose Metabolism Status with Brain Macrostructure and Microstructure: Findings from the UK Biobank
    Ruyi Li, Tingting Geng, Lin Li, Qi Lu, Rui Li, Xue Chen, Yunjing Ou, Sen Liu, Xiaoyu Lin, Qingying Tian, Zixin Qiu, Kai Zhu, Ziyue Tang, Kun Yang, An Pan, Gang Liu
    The Journal of Clinical Endocrinology & Metabolism.2023; 109(1): e234.     CrossRef
  • Association Between Frequency of Social Contact and Brain Atrophy in Community-Dwelling Older People Without Dementia
    Naoki Hirabayashi, Takanori Honda, Jun Hata, Yoshihiko Furuta, Mao Shibata, Tomoyuki Ohara, Yasuko Tatewaki, Yasuyuki Taki, Shigeyuki Nakaji, Tetsuya Maeda, Kenjiro Ono, Masaru Mimura, Kenji Nakashima, Jun-ichi Iga, Minoru Takebayashi, Toshiharu Ninomiya,
    Neurology.2023;[Epub]     CrossRef
  • A diagnosis model for brain atrophy using deep learning and MRI of type 2 diabetes mellitus
    Saba Raoof Syed, Saleem Durai M. A.
    Frontiers in Neuroscience.2023;[Epub]     CrossRef
  • Diabetes: a tipping point in neurodegenerative diseases
    Jose A. Santiago, Mridula Karthikeyan, Madison Lackey, Diana Villavicencio, Judith A. Potashkin
    Trends in Molecular Medicine.2023; 29(12): 1029.     CrossRef
  • Association between Type 2 Diabetes Mellitus and Brain Atrophy: A Meta-Analysis (Diabetes Metab J 2022;46:781-802)
    Tianqi Zhang, Marnie Shaw, Nicolas Cherbuin
    Diabetes & Metabolism Journal.2022; 46(5): 815.     CrossRef
  • Association between Type 2 Diabetes Mellitus and Brain Atrophy: A Meta-Analysis (Diabetes Metab J 2022;46:781-802)
    Se Hee Min
    Diabetes & Metabolism Journal.2022; 46(5): 813.     CrossRef
  • MORPHOFUNCTIONAL CHANGES OF THE BRAIN IN DIABETES MELLITUS
    A. V. Smirnov, A. I Bisinbekova, T. I Faibisovich
    Journal of Volgograd State Medical University.2022; 19(3): 3.     CrossRef
Association between Type 2 Diabetes Mellitus and Brain Atrophy: A Meta-Analysis (Diabetes Metab J 2022;46:781-802)
Tianqi Zhang, Marnie Shaw, Nicolas Cherbuin
Diabetes Metab J. 2022;46(5):815-816.   Published online September 19, 2022
DOI: https://doi.org/10.4093/dmj.2022.0296
[Original]
  • 3,166 View
  • 127 Download
  • 12 Web of Science
  • 3 Crossref
PDFPubReader   ePub   

Citations

Citations to this article as recorded by  
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    Journal of Diabetes Research.2024;[Epub]     CrossRef
  • Association of glycosylated hemoglobin concentrations with structural and functional brain changes in the normoglycemic population: A systematic review
    Yunus Soleymani, Seyed Amir Hossein Batouli, Amin Akbari Ahangar, Ata Pourabbasi
    Journal of Neuroendocrinology.2024;[Epub]     CrossRef
  • Current Insights on the Use of Insulin and the Potential Use of Insulin Mimetics in Targeting Insulin Signalling in Alzheimer’s Disease
    Amy Woodfield, Tatiana Gonzales, Erik Helmerhorst, Simon Laws, Philip Newsholme, Tenielle Porter, Giuseppe Verdile
    International Journal of Molecular Sciences.2022; 23(24): 15811.     CrossRef
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