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Naznin Hossain  (Hossain N) 1 Article
Obesity and Metabolic Syndrome
Associations between Body Mass Index and Chronic Kidney Disease in Type 2 Diabetes Mellitus Patients: Findings from the Northeast of Thailand
Sojib Bin Zaman, Naznin Hossain, Muntasirur Rahman
Diabetes Metab J. 2018;42(4):330-337.   Published online August 21, 2018
DOI: https://doi.org/10.4093/dmj.2017.0052
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  • 11 Web of Science
  • 11 Crossref
AbstractAbstract PDFPubReader   
Background

Chronic kidney disease (CKD) has emerged as a public health burden globally. Obesity and long-term hyperglycaemia can initiate the renal vascular complications in patients with type 2 diabetes mellitus (T2DM). This study aimed to investigate the association of body mass index (BMI) with the CKD in patients with T2DM.

Methods

This study has used retrospective medical records, biochemical reports, and anthropometric measurements of 3,580 T2DM patients which were collected between January to December 2015 from a district hospital in Thailand. CKD was defined according to the measurement of estimated glomerular filtration rate (<60 mL/min/1.73 m2). Multiple logistic regression analysis was used to explore the association between BMI and CKD in patients with T2DM.

Results

The mean age of the participants was 60.86±9.67 years, 53.68% had poor glycaemic control, and 45.21% were overweight. About one-in-four (23.26%) T2DM patients had CKD. The mean BMI of non-CKD group was slightly higher (25.30 kg/m2 vs. 24.30 kg/m2) when compared with CKD patients. Multivariable analysis showed that older age, female sex, hypertension, and microalbuminuria were associated with the presence of CKD. No association was observed between CKD and poorly controlled glycosylated hemoglobin or hypercholesterolemia. Adjusted analysis further showed overweight and obesity were negatively associated with CKD (adjusted odds ratio [AOR], 0.73; 95% confidence interval [CI], 0.58 to 0.93) and (AOR, 0.53; 95% CI, 0.35 to 0.81), respectively.

Conclusion

The negative association of BMI with CKD could reflect the reverse causality. Lower BMI might not lead a diabetic patient to develop CKD, but there are possibilities that CKD leads the patient to experience reduced BMI.

Citations

Citations to this article as recorded by  
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    Diabetology & Metabolic Syndrome.2023;[Epub]     CrossRef
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    Frontiers in Medicine.2021;[Epub]     CrossRef
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    BMC Endocrine Disorders.2021;[Epub]     CrossRef
  • The burden of chronic kidney disease among people with diabetes by insurance schemes: Findings from a primary referral hospital in Thailand
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  • Association between body mass index and estimated glomerular filtration rate in patients with chronic kidney disease of unknown aetiology in Sri Lanka
    M. R. D. L. Kulathunga, M. A. A. Wijayawardena, Ravi Naidu, S. J. Wimalawansa, A. W. Wijeratne
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  • The prevalence of diabetic chronic kidney disease in adult Greek subjects with type 2 diabetes mellitus: A series from hospital-based diabetes clinics
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  • Underweight Increases the Risk of End-Stage Renal Diseases for Type 2 Diabetes in Korean Population: Data From the National Health Insurance Service Health Checkups 2009–2017
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    Diabetes Care.2020; 43(5): 1118.     CrossRef
  • Prevalence and risk factors of chronic kidney disease among Palestinian type 2 diabetic patients: a cross-sectional study
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    BMC Nephrology.2020;[Epub]     CrossRef
  • Effects of Variability in Blood Pressure, Glucose, and Cholesterol Concentrations, and Body Mass Index on End-Stage Renal Disease in the General Population of Korea
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    Journal of Clinical Medicine.2019; 8(5): 755.     CrossRef

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