Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal


Author index

Page Path
HOME > Browse > Author index
Munehiro Kitada  (Kitada M) 1 Article
SIRT1 in Type 2 Diabetes: Mechanisms and Therapeutic Potential
Munehiro Kitada, Daisuke Koya
Diabetes Metab J. 2013;37(5):315-325.   Published online October 17, 2013
  • 6,541 View
  • 96 Download
  • 178 Crossref
AbstractAbstract PDFPubReader   

The prevalence of type 2 diabetes mellitus (T2DM) has been increasing worldwide. Therefore, a novel therapeutic strategy by which to prevent T2DM is urgently required. Calorie restriction (CR) can retard the aging processes, and delay the onset of numerous age-related diseases including diabetes. Metabolic CR mimetics may be therefore included as novel therapeutic targets for T2DM. Sirtuin 1 (SIRT1), a NAD+-dependent histone deacetylase that is induced by CR, is closely associated with lifespan elongation under CR. SIRT1 regulates glucose/lipid metabolism through its deacetylase activity on many substrates. SIRT1 in pancreatic β-cells positively regulates insulin secretion and protects cells from oxidative stress and inflammation, and has positive roles in the metabolic pathway via the modulation in insulin signaling. SIRT1 also regulates adiponectin secretion, inflammation, glucose production, oxidative stress, mitochondrial function, and circadian rhythms. Several SIRT1 activators, including resveratrol have been demonstrated to have beneficial effects on glucose homeostasis and insulin sensitivity in animal models of insulin resistance. Therefore, SIRT1 may be a novel therapeutic target for the prevention of T2DM, implicating with CR. In this review, we summarize current understanding of the biological functions of SIRT1 and discuss its potential as a promising therapeutic target for T2DM.


Citations to this article as recorded by  
  • SIRT1: a promising therapeutic target in type 2 diabetes mellitus
    Ainaz Mihanfar, Maryam Akbarzadeh, Saber Ghazizadeh Darband, Shirin Sadighparvar, Maryam Majidinia
    Archives of Physiology and Biochemistry.2024; 130(1): 13.     CrossRef
  • The Role of Medicinal Plants in the Treatment and Management of Type 2 Diabetes
    Tirna Paul, Kalyani Pathak, Riya Saikia, Urvashee Gogoi, Jon Jyoti Sahariah, Aparoop Das
    Current Traditional Medicine.2024;[Epub]     CrossRef
  • The favorable impacts of cardamom on related complications of diabetes: A comprehensive literature systematic review
    Ramin Nasimi Doost Azgomi, Arash Karimi, Arezoo Moini Jazani
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2024; 18(2): 102947.     CrossRef
  • Heat shock response during the resolution of inflammation and its progressive suppression in chronic-degenerative inflammatory diseases
    Helena Trevisan Schroeder, Carlos Henrique De Lemos Muller, Thiago Gomes Heck, Mauricio Krause, Paulo Ivo Homem de Bittencourt
    Cell Stress and Chaperones.2024; 29(1): 116.     CrossRef
  • circGlis3 promotes β-cell dysfunction by binding to heterogeneous nuclear ribonucleoprotein F and encoding Glis3-348aa protein
    Li Xiong, Yingying Gong, Huashan Liu, Liang Huang, Ziwei Zeng, Xiaobin Zheng, Wenxin Li, Zhenxing Liang, Liang Kang
    iScience.2024; 27(1): 108680.     CrossRef
  • Nephro‐protective effects of alpha‐lipoic acid in type I diabetes
    Kriti Kushwaha, Debojyoti Mandal, Navneet Khurana, Jeena Gupta
    Journal of Biochemical and Molecular Toxicology.2024;[Epub]     CrossRef
  • Lupeol improves bile acid metabolism and metabolic dysfunction-associated steatotic liver disease in mice via FXR signaling pathway and gut-liver axis
    Dongmei Qin, Peiyan Pan, Bo Lyu, Weijun Chen, Yuefeng Gao
    Biomedicine & Pharmacotherapy.2024; 177: 116942.     CrossRef
  • Potential roles of ellagic acid on metabolic variables in diabetes mellitus: A systematic review
    Vahid Maleki, Sepideh Abbaszadeh, Seyyed Morteza Seyyed Shoura, Asma Sohrabnavi, Mojtaba Sepandi, Maryam Taghdir
    Clinical and Experimental Pharmacology and Physiology.2023; 50(2): 121.     CrossRef
  • Agomelatine improves streptozotocin-induced diabetic nephropathy through melatonin receptors/SIRT1 signaling pathway
    Nevertyty M. Mahmoud, Shimaa M. Elshazly, Arwa A. Hassan, Eman Soliman
    International Immunopharmacology.2023; 115: 109646.     CrossRef
  • Effect of Oleanolic acid administration on hepatic AMPK, SIRT-1, IL-6 and NF-κB levels in experimental diabetes
    Hatice Iskender, Eda Dokumacioglu, Kubra Asena Terim Kapakin, Ismail Bolat, Behzat Mokhtare, Armagan Hayirli, Guler Yenice
    Journal of Diabetes & Metabolic Disorders.2023; 22(1): 581.     CrossRef
  • Antidiabetic activity of Berberis brandisiana is possibly mediated through modulation of insulin signaling pathway, inflammatory cytokines and adipocytokines in high fat diet and streptozotocin-administered rats
    Shumaila Mehdi, Malik Hassan Mehmood, Mobeen Ghulam Ahmed, Usman Ali Ashfaq
    Frontiers in Pharmacology.2023;[Epub]     CrossRef
  • The Pathogenesis of Diabetes
    Huiqin Guo, Haili Wu, Zhuoyu Li
    International Journal of Molecular Sciences.2023; 24(8): 6978.     CrossRef
  • Food Polyphenols and Type II Diabetes Mellitus: Pharmacology and Mechanisms
    Rabia Naz, Fatima Saqib, Samir Awadallah, Muqeet Wahid, Muhammad Farhaj Latif, Iram Iqbal, Mohammad S. Mubarak
    Molecules.2023; 28(10): 3996.     CrossRef
  • Pancreatic β-cell heterogeneity in adult human islets and stem cell-derived islets
    Noura Aldous, Abu Saleh Md Moin, Essam M. Abdelalim
    Cellular and Molecular Life Sciences.2023;[Epub]     CrossRef
  • Mechanistic and Etiological Similarities in Diabetes Mellitus and Alzheimer’s Disease: Antidiabetic Drugs as Optimistic Therapeutics in Alzheimer’s Disease
    Subham Das, Anu Kunnath Ramachandran, Debojyoti Halder, Saleem Akbar, Bahar Ahmed, Alex Joseph
    CNS & Neurological Disorders - Drug Targets.2023; 22(7): 973.     CrossRef
  • Resveratrol ameliorates triglyceride accumulation through FXR deacetylation in high glucose-treated HepG2 cells
    Hao Yang, Yongjin Sun, Jinling Zhang, Shan Xu, Lidan Tang, Jinhong Gong, Hufeng Fang, Ying Lin, Jie Ren, Dan Su
    Journal of Functional Foods.2023; 107: 105679.     CrossRef
  • A Potential Role for Sirtuin-1 in Alzheimer’s Disease: Reviewing the Biological and Environmental Evidence
    Mehrane Mehramiz, Tenielle Porter, Eleanor K. O’Brien, Stephanie R. Rainey-Smith, Simon M. Laws, Craig Atwood
    Journal of Alzheimer's Disease Reports.2023; 7(1): 823.     CrossRef
  • Pathophysiology of diabetic kidney disease and autophagy: A review
    Jiawei Yu, Yan Liu, Hongjie Li, Peirong Zhang
    Medicine.2023; 102(30): e33965.     CrossRef
  • Low sirtuin-1 levels are associated with gestational diabetes mellitus
    Minerva Endocrinology.2023;[Epub]     CrossRef
  • Effect of resistance training and high-intensity interval training on metabolic parameters and serum level of Sirtuin1 in postmenopausal women with metabolic syndrome: a randomized controlled trial
    Saeid Shamlou Kazemi, Ali Heidarianpour, Elnaz Shokri
    Lipids in Health and Disease.2023;[Epub]     CrossRef
  • Purple Napiergrass (Pennisetum purpureum Schumach) Hot Water Extracts Ameliorate High-Fat Diet-Induced Obesity and Metabolic Disorders in Mice
    Pin-Yu Ho, Yen-Chun Koh, Ting-Jang Lu, Po-Lin Liao, Min-Hsiung Pan
    Journal of Agricultural and Food Chemistry.2023; 71(51): 20701.     CrossRef
  • The role of sirtuins in the regulatin of oxidative stress during the progress and therapy of type 2 diabetes mellitus
    Jiawen Chen, Qi Wang, Ruiyan Li, Zhe Li, Qizhou Jiang, Fangrong Yan, Junmei Ye
    Life Sciences.2023; 333: 122187.     CrossRef
  • Investigation of polymorphism role in protein structure and function for selected cancer and diabetes disease; a rationale to selection of targets for insilico drug screening
    Christopher Busayo Olowosoke, Tope Abraham Ibisanmi, Chioma Joy Eze, Abayomi Abiodun Shofunde, Tomiwa Lois Olubena, Olalekan Akadiri
    Informatics in Medicine Unlocked.2023; 42: 101342.     CrossRef
  • Folic Acid and Folinic Acid Protect Hearts of Aging Triple-transgenic Alzheimer’s Disease mice via IGF1R/PI3K/AKT and SIRT1/AMPK Pathways
    Da-Tong Ju, Rwei-Fen S. Huang, Bruce Chi-Kang Tsai, Yi-Chen Su, Ping-Ling Chiu, Yung-Ming Chang, V. Vijaya Padma, Tsung-Jung Ho, Chun-Hsu Yao, Wei-Wen Kuo, Chih-Yang Huang
    Neurotoxicity Research.2023; 41(6): 648.     CrossRef
  • Role of microRNA-34a in blood–brain barrier permeability and mitochondrial function in ischemic stroke
    Cole T. Payne, Sidra Tabassum, Silin Wu, Heng Hu, Aaron M. Gusdon, Huimahn A. Choi, Xuefang S. Ren
    Frontiers in Cellular Neuroscience.2023;[Epub]     CrossRef
  • Resveratrol and Markers of Polycystic Ovary Syndrome: a Systematic Review of Animal and Clinical Studies
    Sara Shojaei-Zarghani, Maryam Rafraf
    Reproductive Sciences.2022; 29(9): 2477.     CrossRef
  • Efficacy of artemisinin and its derivatives in animal models of type 2 diabetes mellitus: A systematic review and meta-analysis
    Tingchao Wu, Haoyue Feng, Mingmin He, Rensong Yue, Shaoqi Wu
    Pharmacological Research.2022; 175: 105994.     CrossRef
  • The effect of 12 weeks of training in water on serum levels of SIRT1 and FGF-21, glycemic index, and lipid profile in patients with type 2 diabetes
    Bahram Jamali Gharakhanlou, Solmaz Babaei Bonab
    International Journal of Diabetes in Developing Countries.2022; 42(4): 727.     CrossRef
  • New insights into the role of melatonin in diabetic cardiomyopathy
    Keming Huang, Xianling Luo, Yi Zhong, Li Deng, Jian Feng
    Pharmacology Research & Perspectives.2022;[Epub]     CrossRef
  • Obesity and Male Reproduction: Do Sirtuins Play a Role?
    Federica Barbagallo, Sandro La Vignera, Rossella Cannarella, Laura M. Mongioì, Vincenzo Garofalo, Claudia Leanza, Marta Marino, Aldo E. Calogero, Rosita A. Condorelli
    International Journal of Molecular Sciences.2022; 23(2): 973.     CrossRef
  • Nicotinamide mononucleotide promotes pancreatic islet function through the SIRT1 pathway in mice after severe burns
    Xinzhu Liu, Dawei Li, Zhaoxing Liu, Yaoyao Song, Bohan Zhang, Yu Zang, Wen Zhang, Yuezeng Niu, Chuan’an Shen
    Burns.2022; 48(8): 1922.     CrossRef
  • d-Allulose Ameliorates Hyperglycemia Through IRE1α Sulfonation-RIDD-Sirt1 Decay Axis in the Skeletal Muscle
    Hwa-Young Lee, Geum-Hwa Lee, The-Hiep Hoang, Seon-Ah Park, Juwon Lee, Junghyun Lim, Soonok Sa, Go Eun Kim, Jung Sook Han, Junghyun Kim, Han-Jung Chae
    Antioxidants & Redox Signaling.2022; 37(4-6): 229.     CrossRef
  • GABA and Fermented Curcuma longa L. Extract Enriched with GABA Ameliorate Obesity through Nox4-IRE1α Sulfonation-RIDD-SIRT1 Decay Axis in High-Fat Diet-Induced Obese Mice
    Hwa-Young Lee, Geum-Hwa Lee, The-Hiep Hoang, Yu-Mi Kim, Gi-Hyun Jang, Chang-Hwan Seok, Yun-Geum-Sang Gwak, Junghyun Lim, Junghyun Kim, Han-Jung Chae
    Nutrients.2022; 14(8): 1680.     CrossRef
  • Resveratrol regulates Hsp60 in HEK 293T cells during activation of SIRT1 revealed by nascent protein labeling strategy
    Tian Su, Zhen Wang, Zhengyi Zhang, Zhanwu Hou, Xiao Han, Fei Yang, Huadong Liu
    Food & Nutrition Research.2022;[Epub]     CrossRef
  • Effect of cardamom supplementation on a number of metabolic factors: A systematic review and meta-analysis
    Ghazaleh Nameni, Yousef Moradi, Marsa Zaroudi, Sanaz Jamshidi
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2022; 16(6): 102523.     CrossRef
  • The mitochondrial unfolded protein response: A multitasking giant in the fight against human diseases
    Zixin Zhou, Yumei Fan, Ruikai Zong, Ke Tan
    Ageing Research Reviews.2022; 81: 101702.     CrossRef
  • Cardioprotective Effects of 1-(3,6-Dibromo-carbazol-9-yl)-3-Phenylamino-Propan-2-Ol in Diabetic Hearts via Nicotinamide Phosphoribosyltransferase Activation
    Jared Tur, Sachin L. Badole, Ravikumar Manickam, Kalyan C. Chapalamadugu, Wanling Xuan, Wayne Guida, Jaret J. Crews, Kirpal S. Bisht, Srinivas M. Tipparaju
    Journal of Pharmacology and Experimental Therapeutics.2022; 382(2): 233.     CrossRef
  • Celastrol: A Promising Agent Fighting against Cardiovascular Diseases
    Zhexi Li, Jingyi Zhang, Xulei Duan, Guoan Zhao, Min Zhang
    Antioxidants.2022; 11(8): 1597.     CrossRef
  • The role of Sirtuin 1 in the pathophysiology of polycystic ovary syndrome
    Mali Wu, Jie Zhang, Ran Gu, Fangfang Dai, Dongyong Yang, Yajing Zheng, Wei Tan, Yifan Jia, Bingshu Li, Yanxiang Cheng
    European Journal of Medical Research.2022;[Epub]     CrossRef
  • Anti-apoptotic properties of N-Acetyl cysteine and its effects on of Liver X receptor and Sirtuin 1 expression in the liver of rats exposed to Lead
    Asghar Beigi Harchegani, Sareh Rostami, Zhaleh Mohsenifar, Alireza Beheshti Dafchahi, Fatemeh Mozaffari Moghadam, Mohammad Jaafarzadeh, Saman Seyfizadeh Saraabestan, Najmeh Ranji
    Journal of Trace Elements in Medicine and Biology.2022; 74: 127070.     CrossRef
  • Caloric Restriction, Friend or Foe: Effects on Metabolic Status in Association with the Intestinal Microbiome and Metabolome
    Xiangnan Zhang, Lin Shi, Qiannan Li, Chaofan Song, Ning Han, Tao Yan, Liansheng Zhang, Daoyuan Ren, Yan Zhao, Xingbin Yang
    Journal of Agricultural and Food Chemistry.2022; 70(43): 14061.     CrossRef
  • Effects of Fruit and Vegetable Polyphenols on the Glycemic Control and Metabolic Parameters in Type 2 Diabetes Mellitus: A Review
    Che Anis Jauharah Che Mohd Zin, Wan Mohd Izani Wan Mohamed, Nurzalina Abdul Karim Khan, Wan Rosli Wan Ishak
    Preventive Nutrition and Food Science.2022; 27(3): 257.     CrossRef
  • Berberine mitigates hepatic insulin resistance by enhancing mitochondrial architecture via the SIRT1/Opa1 signalling pathway
    Jia Xu, Yining Zhang, Zhiyi Yu, Yueqi Guan, Yuqian Lv, Meishuang Zhang, Ming Zhang, Li Chen, Xiaoyan Lv, Fengying Guan
    Acta Biochimica et Biophysica Sinica.2022; 54(10): 1464.     CrossRef
  • The Role of p66Shc in Diabetes: A Comprehensive Review from Bench to Bedside
    SeyedehFatemeh Mousavi, Mohammad Amin Khazeei Tabari, Alireza Bagheri, Noosha Samieefar, Negar Shaterian, Roya Kelishadi, Eusebio Chiefari
    Journal of Diabetes Research.2022; 2022: 1.     CrossRef
  • Systematic Insight of Resveratrol Activated SIRT1 Interactome through Proximity Labeling Strategy
    Tian Su, Zhengyi Zhang, Xiao Han, Fei Yang, Zhen Wang, Ying Cheng, Huadong Liu
    Antioxidants.2022; 11(12): 2330.     CrossRef
  • Effects of Resveratrol Supplementation and Exercise on Apoptosis, Lipid Profile, and Expression of Farnesoid X Receptor, Liver X Receptor and Sirtuin 1 Genes in the Liver of Type 1 Diabetic Rats
    Ali Nouri, Parvin Farzanegi, Mohammad Ali Azarbayjani
    Medical Laboratory Journal.2022; 16(4): 39.     CrossRef
  • SIRT1 functional polymorphisms (rs12778366, rs3758391) as genetic biomarkers of susceptibility to type 2 diabetes mellitus in Iranians: a case-control study and computational analysis
    Mohammad Bagher Sadeghi, Alireza Nakhaee, Ramin Saravani, Mohammad Hassan Sadeghi, Saman Sargazi, Milad Heidari Nia
    International Journal of Diabetes in Developing Countries.2021; 41(3): 447.     CrossRef
  • Elucidation of Structural Determinants Delineates the Residues Playing Key Roles in Differential Dynamics and Selective Inhibition of Sirt1–3
    Mrityunjay Singh, Mitul Srivastava, Sharad R. Wakode, Shailendra Asthana
    Journal of Chemical Information and Modeling.2021; 61(3): 1105.     CrossRef
  • Discovery and characterization of small molecule SIRT3-specific inhibitors as revealed by mass spectrometry
    Saurabh Loharch, Sonali Chhabra, Abhinit Kumar, Sapna Swarup, Raman Parkesh
    Bioorganic Chemistry.2021; 110: 104768.     CrossRef
  • Exploring the recent molecular targets for diabetes and associated complications
    Amit Gupta, Tapan Behl, Aayush Sehgal, Shaveta Bhardwaj, Sukhbir Singh, Neelam Sharma, Abdul Hafeez
    Molecular Biology Reports.2021; 48(3): 2863.     CrossRef
  • Opportunities and challenges of algal fucoidan for diabetes management
    Yuxi Wen, Luying Gao, Hengsheng Zhou, Chao Ai, Xiaozhou Huang, Mingfu Wang, Yuyu Zhang, Chao Zhao
    Trends in Food Science & Technology.2021; 111: 628.     CrossRef
  • The effect of N-Acetyl cysteine on the expression of Fxr (Nr1h4), LXRα (Nr1h3) and Sirt1 genes, oxidative stress, and apoptosis in the liver of rats exposed to different doses of cadmium
    Zahra Azarmehr, Najmeh Ranji, Zeinab Khazaei Koohpar, Hadi Habibollahi
    Molecular Biology Reports.2021; 48(3): 2533.     CrossRef
  • Maternal obesity as a risk factor for developing diabetes in offspring: An epigenetic point of view
    Simon Lecoutre, Salwan Maqdasy, Christophe Breton
    World Journal of Diabetes.2021; 12(4): 366.     CrossRef
  • Sirtuin 1 ve Sirtuin 2’nin Tip 2 Diyabet ile İlişkisi
    Turkish Journal of Diabetes and Obesity.2021; 5(1): 81.     CrossRef
  • Human SHC‐transforming protein 1 and its isoforms p66shc: A novel marker for prediabetes
    Herbert F Jelinek, Charlotte Helf, Kinda Khalaf
    Journal of Diabetes Investigation.2021; 12(10): 1881.     CrossRef
  • An Insight into Giant Cell Arteritis Pathogenesis: Evidence for Oxidative Stress and SIRT1 Downregulation
    Alessandro Ianni, Poonam Kumari, Shahriar Tarighi, Flavia Rita Argento, Eleonora Fini, Giacomo Emmi, Alessandra Bettiol, Thomas Braun, Domenico Prisco, Claudia Fiorillo, Matteo Becatti
    Antioxidants.2021; 10(6): 885.     CrossRef
  • Case Report of Impaired Fasting Glucose Improved with Korean Medicine Treatment and Dietetic Therapy
    Eun-mi Kim, Ki-tae Kim
    The Journal of Internal Korean Medicine.2021; 42(2): 175.     CrossRef
  • Can resveratrol modulate sirtuins in obesity and related diseases? A systematic review of randomized controlled trials
    Gabriela Macedo Fraiz, Aline Rosignoli da Conceição, Darlene Larissa de Souza Vilela, Daniela Mayumi Usuda Prado Rocha, Josefina Bressan, Helen Hermana Miranda Hermsdorff
    European Journal of Nutrition.2021; 60(6): 2961.     CrossRef
  • Ameliorative effects of fisetin in letrozole-induced rat model of polycystic ovary syndrome
    Aynaz Mihanfar, Mohammad Nouri, Leila Roshangar, Mohammad Hassan Khadem-Ansari
    The Journal of Steroid Biochemistry and Molecular Biology.2021; 213: 105954.     CrossRef
  • The effect of daily intake of vitamin D-fortified yogurt drink, with and without added calcium, on serum adiponectin and sirtuins 1 and 6 in adult subjects with type 2 diabetes
    Bahareh Nikooyeh, Bruce W. Hollis, Tirang R. Neyestani
    Nutrition & Diabetes.2021;[Epub]     CrossRef
  • Up-regulation of GLP-1R improved the dysfunction of late EPCs under hyperglycemia by regulating SIRT1 expression
    Qiang Tu, Jun-feng Wang, Hua-qiang Xie, Qi Zhao, Jie Fu, Hua-lin Xu, Zheng Cao
    Molecular and Cellular Endocrinology.2021; 538: 111455.     CrossRef
  • Therapeutic Screening of Herbal Remedies for the Management of Diabetes
    Mahmoud Balbaa, Marwa El-Zeftawy, Shaymaa A. Abdulmalek
    Molecules.2021; 26(22): 6836.     CrossRef
  • microRNA‐141 is associated with hepatic steatosis by downregulating the sirtuin1/AMP‐activated protein kinase pathway in hepatocytes
    Zeynab Yousefi, Mitra Nourbakhsh, Zohreh Abdolvahabi, Seyedeh‐Sara Ghorbanhosseini, Zahra Hesari, Sahar Yarahmadi, Samira Ezzati‐Mobasser, Parvane Seiri, Mohammad Borji, Reza Meshkani, Mojtaba Malek
    Journal of Cellular Physiology.2020; 235(2): 880.     CrossRef
  • Trifolium pratense (Red Clover) Improve SIRT1 Expression and Glycogen Content in High Fat Diet‐Streptozotocin Induced Type 2 Diabetes in Rats
    Manisha J. Oza, Yogesh A. Kulkarni
    Chemistry & Biodiversity.2020;[Epub]     CrossRef
  • Additive Effect of Resveratrol on Astrocyte Swelling Post-exposure to Ammonia, Ischemia and Trauma In Vitro
    Mehran Taherian, Michael D. Norenberg, Kiran S. Panickar, Nagarajarao Shamaladevi, Anis Ahmad, Purbasha Rahman, Arumugam R. Jayakumar
    Neurochemical Research.2020; 45(5): 1156.     CrossRef
  • Association of the rs3758391 polymorphism in the SIRT1 gene with diabetic nephropathy and decreased estimated glomerular filtration rate (GFR) in a population from southwest Iran
    Ramin Tavakoli Faradonbeh, Mehrnoosh Zakerkish, Ali Karimi Akhormeh, Narges Mohammadtaghvaei, Mohammad Taha Jalali, Hamid Yaghooti
    International Journal of Diabetes in Developing Countries.2020; 40(1): 99.     CrossRef
  • Hydrogen Sulfide Ameliorates Lung Ischemia-Reperfusion Injury Through SIRT1 Signaling Pathway in Type 2 Diabetic Rats
    Tao Jiang, Weiwei Yang, Hongli Zhang, Zhiqiang Song, Tianhua Liu, Xiangqi Lv
    Frontiers in Physiology.2020;[Epub]     CrossRef
  • Lycium barbarum Polysaccharides Improve Testicular Spermatogenic Function in Streptozotocin-Induced Diabetic Rats
    Xiaocan Lei, Peng Huo, Yaohui Wang, Yuanjie Xie, Qingxiang Shi, Haoyan Tu, Jun Yao, Zhongcheng Mo, Shun Zhang
    Frontiers in Endocrinology.2020;[Epub]     CrossRef
  • Maya gene variants related to the risk of type 2 diabetes in a family-based association study
    Miriam G. Domínguez-Cruz, María de Lourdes Muñoz, Armando Totomoch-Serra, María G. García-Escalante, Juan Burgueño, Nina Valadez-González, Doris Pinto-Escalante, Alvaro Díaz-Badillo
    Gene.2020; 730: 144259.     CrossRef
  • Development of activity-based probes for the protein deacylase Sirt1
    Christopher J. Goetz, Daniel J. Sprague, Brian C. Smith
    Bioorganic Chemistry.2020; 104: 104232.     CrossRef
  • Celastrol attenuates inflammatory responses in adipose tissues and improves skeletal muscle mitochondrial functions in high fat diet-induced obese rats via upregulation of AMPK/SIRT1 signaling pathways
    Mohamad Hafizi Abu Bakar, Khairul Anuar Shariff, Joo Shun Tan, Lai Kuan Lee
    European Journal of Pharmacology.2020; 883: 173371.     CrossRef
  • SCD1 regulates the AMPK/SIRT1 pathway and histone acetylation through changes in adenine nucleotide metabolism in skeletal muscle
    Anna Dziewulska, Aneta M. Dobosz, Agnieszka Dobrzyn, Agnieszka Smolinska, Katarzyna Kolczynska, James M. Ntambi, Pawel Dobrzyn
    Journal of Cellular Physiology.2020; 235(2): 1129.     CrossRef
  • Effect of Quamoclit angulata Extract Supplementation on Oxidative Stress and Inflammation on Hyperglycemia-Induced Renal Damage in Type 2 Diabetic Mice
    Ji Eun Park, Heaji Lee, Hyunkyung Rho, Seong Min Hong, Sun Yeou Kim, Yunsook Lim
    Antioxidants.2020; 9(6): 459.     CrossRef
  • Effect of green cardamom on lipoproteins, glycemic control and anthropometric parameters: A meta-analysis of randomized clinical trials
    Omid Asbaghi, Elham Eslampour, Željko Reiner, Bita Badehnoosh, Fariba Kolahdooz, Sajjad Moradi, Shahrzad Hashemi Dizaji, Zatollah Asemi
    Clinical Nutrition ESPEN.2020; 37: 24.     CrossRef
  • The Potential Roles of Artemisinin and Its Derivatives in the Treatment of Type 2 Diabetes Mellitus
    Ya-yi Jiang, Jia-cheng Shui, Bo-xun Zhang, Jia-wei Chin, Ren-song Yue
    Frontiers in Pharmacology.2020;[Epub]     CrossRef
  • Adipose Tissue SIRT1 Regulates Insulin Sensitizing and Anti-Inflammatory Effects of Berberine
    Yun Shan, Shuchen Zhang, Bin Gao, Shu Liang, Hao Zhang, Xizhong Yu, Juan Zhao, Lifang Ye, Qin Yang, Wenbin Shang
    Frontiers in Pharmacology.2020;[Epub]     CrossRef
  • Inhibition of the SIRT1 signaling pathway exacerbates endoplasmic reticulum stress induced by renal ischemia/reperfusion injury in type 1 diabetic rats
    Jianjian Zhang, Lei Wang, Daojing Gong, Yuanyuan Yang, Xiuheng Liu, Zhiyuan Chen
    Molecular Medicine Reports.2019;[Epub]     CrossRef
  • Beneficial effects of green cardamom on serum SIRT1, glycemic indices and triglyceride levels in patients with type 2 diabetes mellitus: a randomized double‐blind placebo controlled clinical trial
    Mohadeseh Aghasi, Fariba Koohdani, Mostafa Qorbani, Ensieh Nasli‐Esfahani, Shohreh Ghazi‐Zahedi, Hoorieh Khoshamal, Ali Keshavarz, Gity Sotoudeh
    Journal of the Science of Food and Agriculture.2019; 99(8): 3933.     CrossRef
  • A Review of Type 2 Diabetes Mellitus Predisposing Genes
    Tajudeen O. Yahaya, Titilola F. Salisu
    Current Diabetes Reviews.2019; 16(1): 52.     CrossRef
  • Exercise training upregulates SIRT1 to attenuate inflammation and metabolic dysfunction in kidney and liver of diabetic db/db mice
    Hung-Wen Liu, Hao-Han Kao, Chi-Hang Wu
    Nutrition & Metabolism.2019;[Epub]     CrossRef
  • Resveratrol: from enhanced biosynthesis and bioavailability to multitargeting chronic diseases
    Naveet Pannu, Archana Bhatnagar
    Biomedicine & Pharmacotherapy.2019; 109: 2237.     CrossRef
  • The Effect of Resveratrol Supplementation on Cardio‐Metabolic Risk Factors in Patients with Type 2 Diabetes: A Randomized, Double‐Blind Controlled Trial
    Shima Abdollahi, Amin Salehi‐Abargouei, Omid Toupchian, Mohammad Hasan Sheikhha, Hossein Fallahzadeh, Masoud Rahmanian, Mahtab Tabatabaie, Hassan Mozaffari‐Khosravi
    Phytotherapy Research.2019; 33(12): 3153.     CrossRef
  • Sirtuins and diabetes: optimizing the sweetness in the blood
    Abhinav Kanwal, Liston Augustine Dsouza
    Translational Medicine Communications.2019;[Epub]     CrossRef
  • In silico and in vitro identification of candidate SIRT1 activators from Indonesian medicinal plants compounds database
    Azminah Azminah, Linda Erlina, Maksum Radji, Abdul Mun’im, Rezi Riadhi Syahdi, Arry Yanuar
    Computational Biology and Chemistry.2019; 83: 107096.     CrossRef
  • Ginsenoside Rb1 Attenuates High Glucose-Induced Oxidative Injury via the NAD-PARP-SIRT Axis in Rat Retinal Capillary Endothelial Cells
    Chunlan Fan, Qing Ma, Meng Xu, Yuan Qiao, Yi Zhang, Pin Li, Yucong Bi, Minke Tang
    International Journal of Molecular Sciences.2019; 20(19): 4936.     CrossRef
  • Effects and Underlying Mechanisms of Bioactive Compounds on Type 2 Diabetes Mellitus and Alzheimer’s Disease
    Rongzi Li, Yuxian Zhang, Suhail Rasool, Thangiah Geetha, Jeganathan Ramesh Babu
    Oxidative Medicine and Cellular Longevity.2019; 2019: 1.     CrossRef
  • Selection of reference genes for miRNA quantitative PCR and its application in miR-34a/Sirtuin-1 mediated energy metabolism in Megalobrama amblycephala
    Jie Liu, Erteng Jia, Huajuan Shi, Xiangfei Li, Guangzhen Jiang, Cheng Chi, Wenbin Liu, Dingdong Zhang
    Fish Physiology and Biochemistry.2019; 45(5): 1663.     CrossRef
  • Fucoxanthin Alleviates Oxidative Stress through Akt/Sirt1/FoxO3α Signaling to Inhibit HG-Induced Renal Fibrosis in GMCs
    Guanyu Yang, Lin Jin, Dongxiao Zheng, Xiaoliang Tang, Junwei Yang, Lingxuan Fan, Xi Xie
    Marine Drugs.2019; 17(12): 702.     CrossRef
  • Melatonin attenuates acute kidney ischemia/reperfusion injury in diabetic rats by activation of the SIRT1/Nrf2/HO-1 signaling pathway
    Si Shi, Shaoqing Lei, Chaoliang Tang, Kai Wang, Zhongyuan Xia
    Bioscience Reports.2019;[Epub]     CrossRef
  • Rhizoma Paridis total saponins alleviate H2O2‑induced oxidative stress injury by upregulating the Nrf2 pathway
    Baocheng Zhao, Zhenjun Wang, Jiagang Han, Guanghui Wei, Bingqiang Yi, Zhulin Li
    Molecular Medicine Reports.2019;[Epub]     CrossRef
  • Role of sirtuin-1 in diabetic nephropathy
    Wanning Wang, Weixia Sun, Yanli Cheng, Zhonggao Xu, Lu Cai
    Journal of Molecular Medicine.2019; 97(3): 291.     CrossRef
  • Sirtuins and Type 2 Diabetes: Role in Inflammation, Oxidative Stress, and Mitochondrial Function
    Munehiro Kitada, Yoshio Ogura, Itaru Monno, Daisuke Koya
    Frontiers in Endocrinology.2019;[Epub]     CrossRef
  • Mechanistic insights into the effect of lutein on atherosclerosis, vascular dysfunction, and related risk factors: A systematic review of in vivo, ex vivo and in vitro studies
    Fatemeh Hajizadeh-Sharafabad, Zohreh Ghoreishi, Vahid Maleki, Ali Tarighat-Esfanjani
    Pharmacological Research.2019; 149: 104477.     CrossRef
  • Chronic whole-body heat treatment relieves atherosclerotic lesions, cardiovascular and metabolic abnormalities, and enhances survival time restoring the anti-inflammatory and anti-senescent heat shock response in mice
    Maciel Alencar Bruxel, Angela Maria Vicente Tavares, Luiz Domingues Zavarize Neto, Victor de Souza Borges, Helena Trevisan Schroeder, Patricia Martins Bock, Maria Inês Lavina Rodrigues, Adriane Belló-Klein, Paulo Ivo Homem de Bittencourt
    Biochimie.2019; 156: 33.     CrossRef
  • Swimming training by affecting the pancreatic Sirtuin1 (SIRT1) and oxidative stress, improves insulin sensitivity in diabetic male rats
    Rafighe Ghiasi, Roya Naderi, Roghayeh Sheervalilou, Mohammad Reza Alipour
    Hormone Molecular Biology and Clinical Investigation.2019;[Epub]     CrossRef
  • Adipose-Derived Mesenchymal Stem Cells Isolated from Patients with Type 2 Diabetes Show Reduced “Stemness” through an Altered Secretome Profile, Impaired Anti-Oxidative Protection, and Mitochondrial Dynamics Deterioration
    Michalina Alicka, Piotr Major, Michał Wysocki, Krzysztof Marycz
    Journal of Clinical Medicine.2019; 8(6): 765.     CrossRef
  • A novel recombinant peptide INSR-IgG4Fc (Yiminsu) restores insulin sensitivity in experimental insulin resistance models
    Jing Wang, Zhe Shi, Tao Zou, Min-Xu Zou, Hui-Xian Yang, Cai-Ping Zhang, De-Biao Xiang, Li-Mei Lin, Hui-Yu Liu, De-yu Fang, Duan-Fang Liao
    Biomedicine & Pharmacotherapy.2019; 109: 1276.     CrossRef
  • Immunometabolism and Pulmonary Infections: Implications for Protective Immune Responses and Host-Directed Therapies
    Martin Rao, Ernest Dodoo, Alimuddin Zumla, Markus Maeurer
    Frontiers in Microbiology.2019;[Epub]     CrossRef
  • Salvianolic Acid B Attenuates Apoptosis of HUVEC Cells Treated with High Glucose or High Fat via Sirt1 Activation
    Jinghui Zhai, Lina Tao, Yueming Zhang, Huan Gao, Xiaoyu Qu, Yanqing Song, Sixi Zhang
    Evidence-Based Complementary and Alternative Medicine.2019; 2019: 1.     CrossRef
  • Obesity programmed by prenatal dexamethasone and postnatal high-fat diet leads to distinct alterations in nutrition sensory signals and circadian-clock genes in visceral adipose tissue
    Ching-Chou Tsai, Mao-Meng Tiao, Jiunn-Ming Sheen, Li-Tung Huang, You-Lin Tain, I-Chun Lin, Yu-Ju Lin, Yun-Ju Lai, Chih-Cheng Chen, Kow-Aung Chang, Hong-Ren Yu
    Lipids in Health and Disease.2019;[Epub]     CrossRef
  • Mapping Research in the Obesity, Adipose Tissue, and MicroRNA Field: A Bibliometric Analysis
    João Manoel Alves, Ramon Handerson Gomes Teles, Camila do Valle Gomes Gatto, Vitor Rosetto Muñoz, Márcia Regina Cominetti, Ana Cláudia Garcia de Oliveira Duarte
    Cells.2019; 8(12): 1581.     CrossRef
  • Chronic hypoglycemic effect and phytochemical composition of Smilax moranensis roots
    Adriana Romo-Pérez, Sonia Marlen Escandón-Rivera, Adolfo Andrade-Cetto
    Revista Brasileira de Farmacognosia.2019; 29(2): 246.     CrossRef
  • Prevention of kidney cell damage in hyperglycaemia condition by adiponectin
    Sajad Esmaeili, Maryam Motamedrad, Mina Hemmati, Omid Mehrpour, Mohsen Khorashadizadeh
    Cell Biochemistry and Function.2019; 37(3): 148.     CrossRef
  • Molecular Mechanism of the Protective Effect of Zerumbone on Lipopolysaccharide-Induced Inflammation of THP-1 Cell-Derived Macrophages
    Min-Ju Kim, Jung-Mi Yun
    Journal of Medicinal Food.2019; 22(1): 62.     CrossRef
  • Impairment of PPARα and the Fatty Acid Oxidation Pathway Aggravates Renal Fibrosis during Aging
    Ki Wung Chung, Eun Kyeong Lee, Mi Kyung Lee, Goo Taeg Oh, Byung Pal Yu, Hae Young Chung
    Journal of the American Society of Nephrology.2018; 29(4): 1223.     CrossRef
  • Pomegranate Juice Increases Sirtuin1 Protein in Peripheral Blood Mononuclear Cell from Patients with Type 2 Diabetes: A Randomized Placebo Controlled Clinical Trial
    Golbon Sohrab, Javad Nasrollahzadeh, Maryam Tohidi, Hamid Zand, Omid Nikpayam
    Metabolic Syndrome and Related Disorders.2018; 16(8): 446.     CrossRef
  • Effect of resveratrol treatment on graft revascularization after islet transplantation in streptozotocin-induced diabetic mice
    Eun-Mi Lee, Inwon Park, Ye-Jee Lee, Young-Hye You, Ji-Won Kim, Myung-Jun Kim, Yu-Bae Ahn, Pilhan Kim, Seung-Hyun Ko
    Islets.2018; 10(1): 25.     CrossRef
  • miR‐221 negatively regulates inflammation and insulin sensitivity in white adipose tissue by repression of sirtuin‐1 (SIRT1)
    Jie Peng, Yuanfei Zhou, Zhao Deng, Hong Zhang, Yinghui Wu, Tongxing Song, Yang Yang, Hongkui Wei, Jian Peng
    Journal of Cellular Biochemistry.2018; 119(8): 6418.     CrossRef
  • Molecular Imaging of Sirtuin1 Expression–Activity in Rat Brain Using Positron-Emission Tomography–Magnetic-Resonance Imaging with [18F]-2-Fluorobenzoylaminohexanoicanilide
    Robin Bonomi, Vadim Popov, Maxwell T. Laws, David Gelovani, Anjoy Majhi, Aleksandr Shavrin, Xin Lu, Otto Muzik, Nashaat Turkman, Renshyan Liu, Thomas Mangner, Juri G. Gelovani
    Journal of Medicinal Chemistry.2018; 61(16): 7116.     CrossRef
  • Vitamin B 12 Supplementation Influences Methylation of Genes Associated with Type 2 Diabetes and Its Intermediate Traits
    Dilip K Yadav, Smeeta Shrestha, Karen A Lillycrop, Charu V Joglekar, Hong Pan, Joanna D Holbrook, Caroline HD Fall, Chittaranjan S Yajnik, Giriraj R Chandak
    Epigenomics.2018; 10(1): 71.     CrossRef
  • The effects of green cardamom supplementation on blood glucose, lipids profile, oxidative stress, sirtuin-1 and irisin in type 2 diabetic patients: a study protocol for a randomized placebo-controlled clinical trial
    Mohadeseh Aghasi, Shohreh Ghazi-Zahedi, Fariba Koohdani, Fereydoun Siassi, Ensieh Nasli-Esfahani, Ali Keshavarz, Mostafa Qorbani, Hoorieh Khoshamal, Asma Salari-Moghaddam, Gity Sotoudeh
    BMC Complementary and Alternative Medicine.2018;[Epub]     CrossRef
  • LincRNA 1700020I14Rik alleviates cell proliferation and fibrosis in diabetic nephropathy via miR-34a-5p/Sirt1/HIF-1α signaling
    Ailing Li, Rui Peng, Yan Sun, Handeng Liu, Huimin Peng, Zheng Zhang
    Cell Death & Disease.2018;[Epub]     CrossRef
  • Treatment of NASH with Antioxidant Therapy: Beneficial Effect of Red Cabbage on Type 2 Diabetic Rats
    Stéphanie Dal, Remmelt Van der Werf, Catherine Walter, William Bietiger, Elodie Seyfritz, Carole Mura, Claude Peronet, Julie Legrandois, Dalal Werner, Said Ennahar, Fabien Digel, Maillard-Pedracini Elisa, Michel Pinget, Nathalie Jeandidier, Eric Marchioni
    Oxidative Medicine and Cellular Longevity.2018; 2018: 1.     CrossRef
  • Formononetin Treatment in Type 2 Diabetic Rats Reduces Insulin Resistance and Hyperglycemia
    Manisha J. Oza, Yogesh A. Kulkarni
    Frontiers in Pharmacology.2018;[Epub]     CrossRef
  • Tocotrienol-rich fraction supplementation reduces hyperglycemia-induced skeletal muscle damage through regulation of insulin signaling and oxidative stress in type 2 diabetic mice
    Heaji Lee, Yunsook Lim
    The Journal of Nutritional Biochemistry.2018; 57: 77.     CrossRef
  • Circulating soluble RAGE isoforms are attenuated in obese, impaired-glucose-tolerant individuals and are associated with the development of type 2 diabetes
    Edwin R. Miranda, Vikram S. Somal, Jacob T. Mey, Brian K. Blackburn, Edward Wang, Sarah Farabi, Kristian Karstoft, Ciaran E. Fealy, Sangeeta Kashyap, John P. Kirwan, Laurie Quinn, Thomas P. J. Solomon, Jacob M. Haus
    American Journal of Physiology-Endocrinology and Metabolism.2017; 313(6): E631.     CrossRef
  • Combination Treatments with Luteolin and Fisetin Enhance Anti-Inflammatory Effects in High Glucose-Treated THP-1 Cells Through Histone Acetyltransferase/Histone Deacetylase Regulation
    Arang Kim, Jung-Mi Yun
    Journal of Medicinal Food.2017; 20(8): 782.     CrossRef
  • Fucoidan ameliorates pancreatic β‐cell death and impaired insulin synthesis in streptozotocin‐treated β cells and mice via a Sirt‐1‐dependent manner
    Wen‐Chun Yu, Yen‐Lin Chen, Pai‐An Hwang, Tso‐Hsiao Chen, Tz‐Chong Chou
    Molecular Nutrition & Food Research.2017;[Epub]     CrossRef
  • Effects of microRNA-211 on proliferation and apoptosis of lens epithelial cells by targeting SIRT1 gene in diabetic cataract mice
    Kun Zeng, Qi-Gao Feng, Bao-Tao Lin, Da-Hui Ma, Chun-Min Liu
    Bioscience Reports.2017;[Epub]     CrossRef
  • Luteolin and fisetin suppress oxidative stress by modulating sirtuins and forkhead box O3a expression under in vitro diabetic conditions
    Arang Kim, Wooje Lee, Jung-Mi Yun
    Nutrition Research and Practice.2017; 11(5): 430.     CrossRef
  • Melatonin and the pathologies of weakened or dysregulated circadian oscillators
    Rüdiger Hardeland
    Journal of Pineal Research.2017;[Epub]     CrossRef
  • HSF1 acetylation decreases its transcriptional activity and enhances glucolipotoxicity-induced apoptosis in rat and human beta cells
    Indri Purwana, Jun J. Liu, Bernard Portha, Jean Buteau
    Diabetologia.2017; 60(8): 1432.     CrossRef
  • Tangshen formula improves inflammation in renal tissue of diabetic nephropathy through SIRT1/NF-κB pathway
    Yue‑Guang Du, Ke‑Na Zhang, Zong‑Lei Gao, Fengjiao Dai, Xi‑Xi Wu, Ke‑Fu Chai
    Experimental and Therapeutic Medicine.2017;[Epub]     CrossRef
  • MiR-377 promotes white adipose tissue inflammation and decreases insulin sensitivity in obesity via suppression of sirtuin-1 (SIRT1)
    Jie Peng, Yinghui Wu, Zhao Deng, Yuanfei Zhou, Tongxing Song, Yang Yang, Xiaming Zhang, Tao Xu, Mao Xia, Anle Cai, Zuhong Liu, Jian Peng
    Oncotarget.2017; 8(41): 70550.     CrossRef
  • The role of SIRT1 in diabetic cardiomyopathy
    Hedyieh Karbasforooshan, Gholamreza Karimi
    Biomedicine & Pharmacotherapy.2017; 90: 386.     CrossRef
  • Long-term obestatin treatment of mice type 2 diabetes increases insulin sensitivity and improves liver function
    Paweł A. Kołodziejski, Ewa Pruszyńska-Oszmałek, Mathias Z. Strowski, Krzysztof W. Nowak
    Endocrine.2017; 56(3): 538.     CrossRef
  • Overexpressed eNOS upregulates SIRT1 expression and protects mouse pancreatic β cells from apoptosis
    Tingting Hu, Ye Chen, Qian Jiang, Jun Lin, Hewei Li, Ping Wang, Leping Feng
    Experimental and Therapeutic Medicine.2017; 14(2): 1727.     CrossRef
  • Resveratrol attenuates type 2 diabetes mellitus by mediating mitochondrial biogenesis and lipid metabolism via Sirtuin type 1
    Ming‑Ming Cao, Xi Lu, Guo‑Dong Liu, Ying Su, Yan‑Bo Li, Jin Zhou
    Experimental and Therapeutic Medicine.2017;[Epub]     CrossRef
  • Resveratrol Improves Glycemic Control in Type 2 Diabetic Obese Mice by Regulating Glucose Transporter Expression in Skeletal Muscle and Liver
    Caio Yonamine, Erika Pinheiro-Machado, Maria Michalani, Ana Alves-Wagner, João Esteves, Helayne Freitas, Ubiratan Machado
    Molecules.2017; 22(7): 1180.     CrossRef
  • Sleep restriction induced energy, methylation and lipogenesis metabolic switches in rat liver
    Arjun Sengupta, Seth D. Rhoades, Eun Ji Kim, Soumyashant Nayak, Gregory R. Grant, Peter Meerlo, Aalim M. Weljie
    The International Journal of Biochemistry & Cell Biology.2017; 93: 129.     CrossRef
  • Natural mineral-rich water ingestion by ovariectomized fructose-fed Sprague-Dawley rats: effects on sirtuin 1 and glucocorticoid signaling pathways
    Jugal Kishore Das, Milton Severo, Cidália Dionísio Pereira, Emília Patrício, José Magalhães, Rosário Monteiro, Delminda Neves, Maria João Martins
    Menopause.2017; 24(5): 563.     CrossRef
  • SIRT1 attenuates neuropathic pain by epigenetic regulation of mGluR1/5 expressions in type 2 diabetic rats
    Cheng-Hua Zhou, Ming-Xing Zhang, Sha-Sha Zhou, Huan Li, Jian Gao, Lei Du, Xiao-Xing Yin
    Pain.2017; 158(1): 130.     CrossRef
  • MiR-34a contributes to diabetes-related cochlear hair cell apoptosis via SIRT1/HIF-1α signaling
    Ying Lin, Jinjin Shen, Danfeng Li, Jie Ming, Xiangyang Liu, Nana Zhang, Jingbo Lai, Min Shi, Qiuhe Ji, Ying Xing
    General and Comparative Endocrinology.2017; 246: 63.     CrossRef
  • High glucose upregulates endothelin type B receptors in vascular smooth muscle cells via the downregulation of Sirt1
    Yan Lin, Yan Zhao, Enqi Liu
    International Journal of Molecular Medicine.2017;[Epub]     CrossRef
  • Anti-diabetic Effects of Ethanol Extract from Bitter Melon in Mice Fed a High-fat Diet
    Nal Ae Yoon, Juyeong Park, Jiyeon Lee, Joo Yeon Jeong, Hyun-Kyu Kim, Hak Sung Lee, In Guk Hwang, Gu Seob Roh, Hyun Joon Kim, Gyeong Jae Cho, Wan Sung Choi, Dong Hoon Lee, Sang Soo Kang
    Development & Reproduction.2017; 21(3): 259.     CrossRef
  • Thymoquinone ameliorates diabetic phenotype in Diet-Induced Obesity mice via activation of SIRT-1-dependent pathways
    Shpetim Karandrea, Huquan Yin, Xiaomei Liang, Angela L. Slitt, Emma A. Heart, Guillermo López Lluch
    PLOS ONE.2017; 12(9): e0185374.     CrossRef
  • Artesunate protects pancreatic beta cells against cytokine-induced damage via SIRT1 inhibiting NF-κB activation
    L. Yu, J. F. Chen, X. Shuai, Y. Xu, Y. Ding, J. Zhang, W. Yang, X. Liang, D. Su, C. Yan
    Journal of Endocrinological Investigation.2016; 39(1): 83.     CrossRef
  • Mir‐217 promotes inflammation and fibrosis in high glucose cultured rat glomerular mesangial cells via Sirt1/HIF‐1α signaling pathway
    Ying Shao, Chuan Lv, Can Wu, Yuehong Zhou, Qiuyue Wang
    Diabetes/Metabolism Research and Reviews.2016; 32(6): 534.     CrossRef
  • Energetic stress: The reciprocal relationship between energy availability and the stress response
    C.S. Harrell, C.F. Gillespie, G.N. Neigh
    Physiology & Behavior.2016; 166: 43.     CrossRef
  • Ligand-based virtual screening and inductive learning for identification of SIRT1 inhibitors in natural products
    Yunan Sun, Hui Zhou, Hongmei Zhu, Siu-wai Leung
    Scientific Reports.2016;[Epub]     CrossRef
  • Modulation of gut microbiota and delayed immunosenescence as a result of syringaresinol consumption in middle-aged mice
    Si-Young Cho, Juewon Kim, Ji Hae Lee, Ji Hyun Sim, Dong-Hyun Cho, Il-Hong Bae, Hyunbok Lee, Min A. Seol, Hyun Mu Shin, Tae-Joo Kim, Dae-Yong Kim, Su-Hyung Lee, Song Seok Shin, Sin-Hyeog Im, Hang-Rae Kim
    Scientific Reports.2016;[Epub]     CrossRef
  • Frailty and sarcopenia as the basis for the phenotypic manifestation of chronic diseases in older adults
    Javier Angulo, Mariam El Assar, Leocadio Rodríguez-Mañas
    Molecular Aspects of Medicine.2016; 50: 1.     CrossRef
  • Sirt1 is essential for resveratrol enhancement of hypoxia-induced autophagy in the type 2 diabetic nephropathy rat
    Liqun Ma, Rongguo Fu, Zhaoyang Duan, Jiamei Lu, Jie Gao, Lifang Tian, Zhian Lv, Zhao Chen, Jin Han, Lining Jia, Li Wang
    Pathology - Research and Practice.2016; 212(4): 310.     CrossRef
  • The Ticking of the Epigenetic Clock: Antipsychotic Drugs in Old Age
    Adonis Sfera, Carolina Osorio, Luzmin Inderias, Michael Cummings
    Frontiers in Endocrinology.2016;[Epub]     CrossRef
  • ZLN005 protects cardiomyocytes against high glucose-induced cytotoxicity by promoting SIRT1 expression and autophagy
    Wenju Li, Xiaoli Li, Bin Wang, Yan Chen, Aiping Xiao, Di Zeng, Dongbo Ou, Song Yan, Wei Li, Qiangsun Zheng
    Experimental Cell Research.2016; 345(1): 25.     CrossRef
  • How much successful are the medicinal chemists in modulation of SIRT1: A critical review
    Ashwani Kumar, Shilpi Chauhan
    European Journal of Medicinal Chemistry.2016; 119: 45.     CrossRef
  • Network Based Approach in the Establishment of the Relationship between Type 2 Diabetes Mellitus and Its Complications at the Molecular Level Coupled with Molecular Docking Mechanism
    Shailima Rampogu, Mary Rampogu Lemuel
    BioMed Research International.2016; 2016: 1.     CrossRef
  • 1,4-Dihydropyridines Active on the SIRT1/AMPK Pathway Ameliorate Skin Repair and Mitochondrial Function and Exhibit Inhibition of Proliferation in Cancer Cells
    Sergio Valente, Paolo Mellini, Francesco Spallotta, Vincenzo Carafa, Angela Nebbioso, Lucia Polletta, Ilaria Carnevale, Serena Saladini, Daniela Trisciuoglio, Chiara Gabellini, Maria Tardugno, Clemens Zwergel, Chiara Cencioni, Sandra Atlante, Sébastien Mo
    Journal of Medicinal Chemistry.2016; 59(4): 1471.     CrossRef
  • Antidiabetic Effects of Resveratrol: The Way Forward in Its Clinical Utility
    Omolola R. Oyenihi, Ayodeji B. Oyenihi, Anne A. Adeyanju, Oluwafemi O. Oguntibeju
    Journal of Diabetes Research.2016; 2016: 1.     CrossRef
  • Mechanism of uncoupling protein 2-mediated myocardial injury in hypothermic preserved rat hearts
    Gai-Ge Chen, Jin-Bin Yan, Xu-Ming Wang, Ming-Zhi Zheng, Jian-Ping Jiang, Xin-Mei Zhou, Bin Cai, Yue-Liang Shen
    Molecular Medicine Reports.2016; 14(2): 1857.     CrossRef
  • Identification of sirtuin 1 as a promising therapeutic target for hypertrophic scars
    Xiao‐Zhi Bai, Jia‐Qi Liu, Long‐Long Yang, Lei Fan, Ting He, Lin‐Lin Su, Ji‐Hong Shi, Chao‐Wu Tang, Zhao Zheng, Da‐Hai Hu
    British Journal of Pharmacology.2016; 173(10): 1589.     CrossRef
  • Physiological regulation of the heat shock response by glutamine: implications for chronic low-grade inflammatory diseases in age-related conditions
    Jaqueline Santos Moreira Leite, Vinicius Fernandes Cruzat, Mauricio Krause, Paulo Ivo Homem de Bittencourt
    Nutrire.2016;[Epub]     CrossRef
  • In Patients with Coronary Artery Disease and Type 2 Diabetes, SIRT1 Expression in Circulating Mononuclear Cells Is Associated with Levels of Inflammatory Cytokines but Not with Coronary Lesions
    Yuanmin Li, Jing Ni, Rong Guo, Weiming Li
    BioMed Research International.2016; 2016: 1.     CrossRef
  • The role of bile acids in metabolic regulation
    Libor Vítek, Martin Haluzík
    Journal of Endocrinology.2016; 228(3): R85.     CrossRef
  • New Perspectives on the Development of Antiobesity Drugs
    Luca Costantino, Daniela Barlocco
    Future Medicinal Chemistry.2015; 7(3): 315.     CrossRef
  • SIRT1 protects against myocardial ischemia–reperfusion injury via activating eNOS in diabetic rats
    Mingge Ding, Jingyi Lei, Hongcheng Han, Weibo Li, Yinxian Qu, Enqing Fu, Feng Fu, Xiaoming Wang
    Cardiovascular Diabetology.2015;[Epub]     CrossRef
  • Resveratrol and diabetes: from animal to human studies
    Tomasz Szkudelski, Katarzyna Szkudelska
    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2015; 1852(6): 1145.     CrossRef
  • Resveratrol restores the circadian rhythmic disorder of lipid metabolism induced by high-fat diet in mice
    Linjie Sun, Yan Wang, Yu Song, Xiang-Rong Cheng, Shufang Xia, Md Ramim Tanver Rahman, Yonghui Shi, Guowei Le
    Biochemical and Biophysical Research Communications.2015; 458(1): 86.     CrossRef
  • DPP‐4 Inhibitor Linagliptin Attenuates Aβ‐induced Cytotoxicity through Activation of AMPK in Neuronal Cells
    Edy Kornelius, Chih‐Li Lin, Hsiu‐Han Chang, Hsin‐Hua Li, Wen‐Nung Huang, Yi‐Sun Yang, Ying‐Li Lu, Chiung‐Huei Peng, Chien‐Ning Huang
    CNS Neuroscience & Therapeutics.2015; 21(7): 549.     CrossRef
  • Effects of Caloric Intake on Learning and Memory Function in Juvenile C57BL/6J Mice
    Bao-Lei Xu, Rong Wang, Li-Na Ma, Wen Dong, Zhi-Wei Zhao, Jing-Shuang Zhang, Yu-Lan Wang, Xu Zhang
    BioMed Research International.2015; 2015: 1.     CrossRef
  • Inhibition of microRNA-9-3p reduces lipid accumulation in HepG2 cells by targeting the expression of sirtuin type 1
    Molecular Medicine Reports.2015; 12(5): 7742.     CrossRef
  • Bioinformatics analysis of abnormal DNA methylation in muscle samples from monozygotic twins discordant for type 2 diabetes
    Molecular Medicine Reports.2015; 12(1): 351.     CrossRef
  • Resveratrol Protects against Methylglyoxal-Induced Hyperglycemia and Pancreatic Damage In Vivo
    An-Sheng Cheng, Yu-Hsiang Cheng, Chi-Ying Lee, Chin-Yuan Chung, Wen-Chang Chang
    Nutrients.2015; 7(4): 2850.     CrossRef
  • Ameliorative effects of lutein on non-alcoholic fatty liver disease in rats
    Xiang Qiu
    World Journal of Gastroenterology.2015; 21(26): 8061.     CrossRef
  • Histone hypoacetylation and increased histone deacetylases in peripheral blood mononuclear cells from patients with Graves' disease
    Ni Yan, Jiao-zhen Zhou, Jin-an Zhang, Tiantian Cai, Wen Zhang, Yuan Wang, Fatuma-Said Muhali, Lijuan Guan, Rong-hua Song
    Molecular and Cellular Endocrinology.2015; 414: 143.     CrossRef
  • Resveratrol relieves ischemia‑induced oxidative stress in the hippocampus by activating SIRT1
    Zhuangzhi Meng, Jianguo Li, Honglin Zhao, Haiying Liu, Guowei Zhang, Lingzhan Wang, He Hu, Di Li, Mingjing Liu, Fulong Bi, Xiaoping Wang, Geng Tian, Qiang Liu, Batu Buren
    Experimental and Therapeutic Medicine.2015;[Epub]     CrossRef
  • Could changes in adiponectin drive the effect of statins on the risk of new-onset diabetes? The case of pitavastatin
    Lorenzo Arnaboldi, Alberto Corsini
    Atherosclerosis Supplements.2015; 16: 1.     CrossRef
  • Obesity-Related Oxidative Stress: the Impact of Physical Activity and Diet Manipulation
    Chun-Jung Huang, Matthew J. McAllister, Aaron L. Slusher, Heather E. Webb, J. Thomas Mock, Edmund O. Acevedo
    Sports Medicine - Open.2015;[Epub]     CrossRef
  • SIRT1 suppresses cardiomyocyte apoptosis in diabetic cardiomyopathy: An insight into endoplasmic reticulum stress response mechanism
    Rong Guo, Weijing Liu, Baoxin Liu, Buchun Zhang, Weiming Li, Yawei Xu
    International Journal of Cardiology.2015; 191: 36.     CrossRef
  • Fenofibrate reduces inflammation in obese patients with or without type 2 diabetes mellitus via sirtuin 1/fetuin A axis
    Mohamed H. Noureldein, Rania S. Abd El-Razek, Mohamed H. El-Hefnawy, Hala O. El-Mesallamy
    Diabetes Research and Clinical Practice.2015; 109(3): 513.     CrossRef
  • Plasma levels of SIRT1 associate with non-alcoholic fatty liver disease in obese patients
    Stefania Mariani, Daniela Fiore, Sabrina Basciani, Agnese Persichetti, Savina Contini, Carla Lubrano, Luisa Salvatori, Andrea Lenzi, Lucio Gnessi
    Endocrine.2015; 49(3): 711.     CrossRef
  • Platycodon grandiflorum A. De Candolle Ethanolic Extract Inhibits Adipogenic Regulators in 3T3-L1 Cells and Induces Mitochondrial Biogenesis in Primary Brown Preadipocytes
    Hye-Lin Kim, Jinbong Park, Hyewon Park, Yunu Jung, Dong-Hyun Youn, JongWook Kang, Mi-Young Jeong, Jae-Young Um
    Journal of Agricultural and Food Chemistry.2015; 63(35): 7721.     CrossRef
  • Amazonian Fruits: An Overview of Nutrients, Calories and Use in Metabolic Disorders
    Moacir Couto de Andrade Júnior, Jerusa Souza Andrade
    Food and Nutrition Sciences.2014; 05(17): 1692.     CrossRef
  • Protective effects of resveratrol on postmenopausal osteoporosis: regulation of SIRT1-NF-κB signaling pathway
    Jing Feng, Shuai Liu, Sai Ma, Jian Zhao, Wei Zhang, Wei Qi, Pengchong Cao, Zheng Wang, Wei Lei
    Acta Biochimica et Biophysica Sinica.2014; 46(12): 1024.     CrossRef
  • The fat cell senescence hypothesis
    Philip Newsholme, Paulo I. Homem de Bittencourt
    Current Opinion in Clinical Nutrition and Metabolic Care.2014; 17(4): 295.     CrossRef
  • Sirt1 and Sirt6 Mediate Beneficial Effects of Rosiglitazone on Hepatic Lipid Accumulation
    Soo Jin Yang, Jung Mook Choi, Eugene Chang, Sung Woo Park, Cheol-Young Park, Aimin Xu
    PLoS ONE.2014; 9(8): e105456.     CrossRef
  • Resveratrol ameliorates hepatic metaflammation and inhibits NLRP3 inflammasome activation
    Soo Jin Yang, Yunsook Lim
    Metabolism.2014; 63(5): 693.     CrossRef
  • Role of SIRT1 in Streptococcus pneumoniae-induced human β-defensin-2 and interleukin-8 expression in A549 cell
    Li Lin, Shun-hang Wen, Shu-zhen Guo, Xiao-yan Su, Hu-jun Wu, Lei Chong, Hai-lin Zhang, Wei-xi Zhang, Chang-chong Li
    Molecular and Cellular Biochemistry.2014; 394(1-2): 199.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal
Close layer