Citations

Citations to this article as recorded by  

• Mitochondria: fundamental characteristics, challenges, and impact on aging
  Runyu Liang, Luwen Zhu, Yongyin Huang, Jia Chen, Qiang Tang
  Biogerontology.2024; 25(6): 923.     CrossRef
• The Origin of Natural Neurostimulation: A Narrative Review of Noninvasive Brain Stimulation Techniques
  Igor Val Danilov
  OBM Neurobiology.2024; 08(04): 1.     CrossRef
• A systematic review of the neuroprotective role and biomarker potential of GDF15 in neurodegeneration
  Finula I. Isik, Shannon Thomson, John F. Cueto, Jessica Spathos, Samuel N. Breit, Vicky W. W. Tsai, David A. Brown, Caitlin A. Finney
  Frontiers in Immunology.2024;[Epub]     CrossRef

Growth differentiation factor 15 (GDF15) is receiving great interest beyond its role as an aging and disease-related biomarker. Recent discovery of its receptor, glial cell line-derived neurotrophic factor (GDNF) family receptor α-like (GFRAL), suggests a central role in appetite regulation. However, there is also considerable evidence that GDF15 may have peripheral activity through an as-of-yet undiscovered mode of action. This raises the question as to whether increased GDF15 induction during pathophysiologic conditions also suppresses appetite. The present review will briefly introduce the discovery of GDF15 and describe the different contexts under which GDF15 is induced, focusing on its induction during mitochondrial dysfunction. We will further discuss the metabolic role of GDF15 under various pathophysiological conditions and conclude with possible therapeutic applications.

Citations

Citations to this article as recorded by  

• Growth differentiation factor-15 is an IFN-γ regulated mediator of infection-induced weight loss and the hepatic FGF21 response
  Jojo Reyes, Yanlin Zhao, Krushang Pandya, George S. Yap
  Brain, Behavior, and Immunity.2024; 116: 24.     CrossRef
• Biomarkers of disability worsening in inactive primary progressive multiple sclerosis
  Maria-Elizabeth Baeva, Isabelle Tottenham, Marcus Koch, Carlos Camara-Lemarroy
  Journal of Neuroimmunology.2024; 387: 578268.     CrossRef
• Tricarboxylic Acid Cycle Intermediates and Individual Ageing
  Natalia Kurhaluk
  Biomolecules.2024; 14(3): 260.     CrossRef
• The implicated role of GDF15 in gastrointestinal cancer
  Yingqi Xue, Yan Zhang, Yale Su, Jiangqi Zhao, Daoquan Yu, Yunju Jo, Jongkil Joo, Hyun Joo Lee, Dongryeol Ryu, Shibo Wei
  European Journal of Clinical Investigation.2024;[Epub]     CrossRef
• Correlation Between Growth Differentiation Factor-15 and Peripheral Neuropathy in Patients with Type 2 Diabetes Mellitus
  Yue Li, Yuhui Wang, Yonghong Cao, Xinxiu Zhang, Wu Dai, Yiran Zhao, Lei Zhang, Xiaofang Han
  Diabetes, Metabolic Syndrome and Obesity.2024; Volume 17: 3019.     CrossRef
• Intertwined roles for GDF-15, HMGB1, and MIG/CXCL9 in Pediatric Acute Liver Failure
  Ruben Zamora, Jinling Yin, Derek Barclay, James E. Squires, Yoram Vodovotz
  Frontiers in Systems Biology.2024;[Epub]     CrossRef
• A long‐acting GDF15 analog causes robust, sustained weight loss and reduction of food intake in an obese nonhuman primate model
  Songmao Zheng, David Polidori, Yuanping Wang, Brian Geist, Xiefan Lin‐Schmidt, Jennifer L. Furman, Serena Nelson, Andrea R. Nawrocki, Simon A. Hinke
  Clinical and Translational Science.2023; 16(8): 1431.     CrossRef
• GDF15 enhances body weight and adiposity reduction in obese mice by leveraging the leptin pathway
  Samuel N. Breit, Rakesh Manandhar, Hong-Ping Zhang, Michelle Lee-Ng, David A. Brown, Vicky Wang-Wei Tsai
  Cell Metabolism.2023; 35(8): 1341.     CrossRef
• Serum growth differentiation factor-15 (GDF-15) is a biomarker of cardiac manifestations in children with COVID-19
  Sally Raafat Ishak, Mona Mostafa El Ganzoury, Eman Mahmoud Fouda, Maha Ahmad Anwar, Amany Moustafa Kamal, Heba Mostafa Hamza, Nehad Ahmed Bakry
  European Journal of Medical Research.2023;[Epub]     CrossRef
• Understanding the molecular basis of anorexia and tissue wasting in cancer cachexia
  Eunbyul Yeom, Kweon Yu
  Experimental & Molecular Medicine.2022; 54(4): 426.     CrossRef
• Investigating the combination of plasma amyloid-beta and geroscience biomarkers on the incidence of clinically meaningful cognitive decline in older adults
  Wan-Hsuan Lu, Kelly Virecoulon Giudici, John E. Morley, Sophie Guyonnet, Angelo Parini, Geetika Aggarwal, Andrew D. Nguyen, Yan Li, Randall J. Bateman, Bruno Vellas, Philipe de Souto Barreto, Bruno Vellas, Sophie Guyonnet, Isabelle Carrié, Lauréane Brigit
  GeroScience.2022; 44(3): 1489.     CrossRef
• The Potential Role of Growth Differentiation Factor 15 in COVID-19: A Corollary Subjective Effect or Not?
  Ahmad O. Babalghith, Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Michel De Waard, Jean-Marc Sabatier, Hebatallah M. Saad, Gaber El-Saber Batiha
  Diagnostics.2022; 12(9): 2051.     CrossRef
• Metformin and growth differentiation factor 15 (GDF15) in type 2 diabetes mellitus: A hidden treasure
  Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb, Athanasios Alexiou, Marios Papadakis, Eman Hassan Nadwa, Sarah M. Albogami, Mohammed Alorabi, Hebatallah M. Saad, Gaber El‐Saber Batiha
  Journal of Diabetes.2022; 14(12): 806.     CrossRef
• Effects of Exercise Intervention on Mitochondrial Stress Biomarkers in Metabolic Syndrome Patients: A Randomized Controlled Trial
  Jae Seung Chang, Jun Namkung
  International Journal of Environmental Research and Public Health.2021; 18(5): 2242.     CrossRef
• Neurological & psychological aspects of Barth syndrome: Clinical manifestations and potential pathogenic mechanisms
  Melissa Olivar-Villanueva, Mindong Ren, Colin K.L. Phoon
  Mitochondrion.2021; 61: 188.     CrossRef
• The metabolic role of spermidine in obesity: Evidence from cells to community
  Yanee Choksomngam, Sintip Pattanakuhar, Nipon Chattipakorn, Siriporn C. Chattipakorn
  Obesity Research & Clinical Practice.2021; 15(4): 315.     CrossRef
• The Role of GDF15 as a Myomitokine
  Kornelia Johann, Maximilian Kleinert, Susanne Klaus
  Cells.2021; 10(11): 2990.     CrossRef

Obesity results in an inflammatory microenvironment in adipose tissue, leading to the deterioration of tissue protective mechanisms. Although recent studies suggested the importance of type 2 immunity in an anti-inflammatory microenvironment in adipose tissue, the regulatory effects of T helper 2 (Th2) cytokines on systemic metabolic regulation are not fully understood. Recently, we identified the roles of the Th2 cytokine (interleukin 4 [IL-4] and IL-13)-induced adipokine, growth differentiation factor 15 (GDF15), in adipose tissue in regulating systemic glucose metabolism via signal transducer and activator of transcription 6 (STAT6) activation. Moreover, we showed that mitochondrial oxidative phosphorylation is required to maintain these macrophage-regulating autocrine and paracrine signaling pathways via Th2 cytokine-induced secretion of GDF15. In this review, we discuss how the type 2 immune response and Th2 cytokines regulate metabolism in adipose tissue. Specifically, we review the systemic regulatory roles of Th2 cytokines in metabolic disease and the role of mitochondria in maintenance of type 2 responses in adipose tissue homeostasis.

Citations

Citations to this article as recorded by  

• Orchestration of the Adipose Tissue Immune Landscape by Adipocytes
  David Bradley, Tuo Deng, Dharti Shantaram, Willa A. Hsueh
  Annual Review of Physiology.2024; 86(1): 199.     CrossRef
• Growth and differentiation factor-15: A link between inflammaging and cardiovascular disease
  Balázs Bence Nyárády, Loretta Zsuzsa Kiss, Zsolt Bagyura, Béla Merkely, Edit Dósa, Orsolya Láng, László Kőhidai, Éva Pállinger
  Biomedicine & Pharmacotherapy.2024; 174: 116475.     CrossRef
• Evaluation of Mitochondrial Function in Blood Samples Shows Distinct Patterns in Subjects with Thyroid Carcinoma from Those with Hyperplasia
  Julia Bernal-Tirapo, María Teresa Bayo Jiménez, Pedro Yuste-García, Isabel Cordova, Ana Peñas, Francisco-Javier García-Borda, Cesar Quintela, Ignacio Prieto, Cristina Sánchez-Ramos, Eduardo Ferrero-Herrero, María Monsalve
  International Journal of Molecular Sciences.2023; 24(7): 6453.     CrossRef
• A Supportive Role of Mesenchymal Stem Cells on Insulin-Producing Langerhans Islets with a Specific Emphasis on The Secretome
  Ronit Vogt Sionov, Ronit Ahdut-HaCohen
  Biomedicines.2023; 11(9): 2558.     CrossRef
• Gdf15 deletion exacerbates acute lung injuries induced by intratracheal inoculation of aerosolized ricin in mice
  Mengyun Deng, Duo Su, Nan Xiao, Zhipeng Zhang, Yifeng Wang, Fuliang Zong, Sha Li, Jinglin Wang, Dongsheng Zhou, Yuee Zhao, Huiying Yang
  Toxicology.2022; 469: 153135.     CrossRef
• Role of PPAR Receptor and Ligands in the Pathogenesis and Therapy of Hematologic Malignancies
  Jian Wu, Min Zhang, Allison Faircloth
  Hemato.2022; 3(3): 422.     CrossRef
• Macrophage and Adipocyte Mitochondrial Dysfunction in Obesity-Induced Metabolic Diseases
  Liwen Wang, Jie Hu, Haiyan Zhou
  The World Journal of Men's Health.2021; 39(4): 606.     CrossRef
• Th2 Cytokines Increase the Expression of Fibroblast Growth Factor 21 in the Liver
  Seul-Gi Kang, Seong-Eun Lee, Min-Jeong Choi, Joon-Young Chang, Jung-Tae Kim, Ben-Yuan Zhang, Yea-Eun Kang, Ju-Hee Lee, Hyon-Seung Yi, Minho Shong
  Cells.2021; 10(6): 1298.     CrossRef
• Growth/Differentiation Factor-15 (GDF-15): From Biomarker to Novel Targetable Immune Checkpoint
  Jörg Wischhusen, Ignacio Melero, Wolf Herman Fridman
  Frontiers in Immunology.2020;[Epub]     CrossRef
• Transcriptional, Epigenetic and Metabolic Programming of Tumor-Associated Macrophages
  Irina Larionova, Elena Kazakova, Marina Patysheva, Julia Kzhyshkowska
  Cancers.2020; 12(6): 1411.     CrossRef

Citations

Citations to this article as recorded by  

• Effect of a 6-Week Carbohydrate-Reduced High-Protein Diet on Levels of FGF21 and GDF15 in People With Type 2 Diabetes
  Michael M Richter, Mads N Thomsen, Mads J Skytte, Sasha A S Kjeldsen, Amirsalar Samkani, Jan Frystyk, Faidon Magkos, Jens J Holst, Sten Madsbad, Thure Krarup, Steen B Haugaard, Nicolai J Wewer Albrechtsen
  Journal of the Endocrine Society.2024;[Epub]     CrossRef
• Serum Growth Differentiation Factor 15 Levels Predict the Incidence of Frailty among Patients with Cardiometabolic Diseases
  Kazuhito Oba, Joji Ishikawa, Yoshiaki Tamura, Yasunori Fujita, Masafumi Ito, Ai Iizuka, Yoshinori Fujiwara, Remi Kodera, Kenji Toyoshima, Yuko Chiba, Masashi Tanaka, Atsushi Araki
  Gerontology.2024; 70(5): 517.     CrossRef
• Growth differentiation factor 15 and malnutrition in older adults
  Nazanin Rostami, Blanca Fabre-Estremera, Antonio Buño-Soto, José R Banegas, Fernando Rodríguez-Artalejo, Rosario Ortolá
  The Journal of nutrition, health and aging.2024; 28(6): 100230.     CrossRef
• Evaluation of the relation between subclinical systolic dysfunction defined by four-dimensional speckle-tracking echocardiography and growth differentiation factor-15 levels in patients with acromegaly
  Busra Firlatan, Ugur Nadir Karakulak, Vedat Hekimsoy, Burcin Gonul Iremli, Incilay Lay, Deniz Yuce, Selcuk Dagdelen, Giray Kabakci, Tomris Erbas
  Hormones.2024; 23(4): 777.     CrossRef
• Nausea, vomiting and conflict in pregnancy
  Bernard J Crespi
  Evolution, Medicine, and Public Health.2024; 12(1): 75.     CrossRef
• Correlations between growth differentiation factor 15 (GDF-15) serum levels and gene polymorphism with type 2 diabetes mellitus
  Qiumei Liu, Lidong Qin, Yujian Liang, Min Xu, Junling Zhang, Xiaoting Mo, Xu Tang, Yufu Lu, Xuexiu Wang, Jiejing Cao, Chuwu Huang, Jiahui Rong, Kaisheng Teng, Linhai Zhao, Songju Wu, Lei Luo, Qinyi Guan, TianTian Zhang, Wenjia Jin, Jian Qin, Jiansheng Cai
  Heliyon.2024; 10(12): e33044.     CrossRef
• Growth differentiation factor 15 is not modified after weight loss induced by liraglutide in South Asians and Europids with type 2 diabetes mellitus
  Carlijn A. Hoekx, Maaike E. Straat, Maurice B. Bizino, Huub J. van Eyk, Hildebrandus J. Lamb, Johannes W. A. Smit, Ingrid M. Jazet, Saskia C. A. de Jager, Mariëtte R. Boon, Borja Martinez‐Tellez
  Experimental Physiology.2024; 109(8): 1292.     CrossRef
• GDF-15 and mtDNA Deletions Are Useful Biomarkers of Mitochondrial Dysfunction in Insulin Resistance and PCOS
  Vera Varhegyi, Anna Modos, Domonkos Trager, Dora Gerszi, Eszter Maria Horvath, Miklos Sipos, Nandor Acs, Maria Judit Molnar, Szabolcs Varbiro, Aniko Gal
  International Journal of Molecular Sciences.2024; 25(20): 10916.     CrossRef
• Alterations in Biomarkers Associated with Cardiovascular Health and Obesity with Short-Term Lifestyle Changes in Overweight Women: The Role of Exercise and Diet
  Nezihe Şengün, Ragıp Pala, Vedat Çınar, Taner Akbulut, Alin Larion, Johnny Padulo, Luca Russo, Gian Mario Migliaccio
  Medicina.2024; 60(12): 2019.     CrossRef
• Exploration of meteorin-like peptide (metrnl) predictors in type 2 diabetic patients: the potential role of irisin, and other biochemical parameters
  Yaser Khajebishak, Amir Hossein Faghfouri, Ali Soleimani, Sadra Madani, Laleh Payahoo
  Hormone Molecular Biology and Clinical Investigation.2023; 44(2): 127.     CrossRef
• Relationship between meteorin-like peptide (Metrnl) serum levels and inflammatory cytokines, oxidative stress biomarkers and body composition parameters in type 2 diabetes patients
  Yaser Khajebishak, Sadra Madani, Amir Hossein Faghfouri, Ali Soleimani, Sara Ilaei, Said Peyrovi, Laleh Payahoo
  Nutrition & Food Science.2023; 53(5): 861.     CrossRef
• Effects of acute exercise and exercise training on plasma GDF15 concentrations and associations with appetite and cardiometabolic health in individuals with overweight or obesity – A secondary analysis of a randomized controlled trial
  Jonas Salling Quist, Anders Bue Klein, Kristine Færch, Kristine Beaulieu, Mads Rosenkilde, Anne Sofie Gram, Anders Sjödin, Signe Torekov, Bente Stallknecht, Christoffer Clemmensen, Martin Bæk Blond
  Appetite.2023; 182: 106423.     CrossRef
• Significant increase of serum extracellular vesicle-packaged growth differentiation factor 15 in type 2 diabetes mellitus: a cross-sectional study
  Wen Zhao, Xinwei Li, Xinxin Li, Lu Peng, Yu Li, Yunhui Du, Jianxun He, Yanwen Qin, Huina Zhang
  European Journal of Medical Research.2023;[Epub]     CrossRef
• Association between growth differentiation factor 15 levels and gestational diabetes mellitus: A combined analysis
  Yi-Cheng Lu, Song-Liang Liu, Yu-Shan Zhang, Fei Liang, Xiao-Yan Zhu, Yue Xiao, Jing Wang, Cong Ding, Sudipta Banerjee, Jie-Yun Yin, Qiu-Ping Ma
  Frontiers in Endocrinology.2023;[Epub]     CrossRef
• Metformin triggers a kidney GDF15-dependent area postrema axis to regulate food intake and body weight
  Song-Yang Zhang, Kyla Bruce, Zahra Danaei, Rosa J.W. Li, Daniel R. Barros, Rachel Kuah, Yu-Mi Lim, Laura H. Mariani, David Z. Cherney, Jennifer F.M. Chiu, Heather N. Reich, Tony K.T. Lam
  Cell Metabolism.2023; 35(5): 875.     CrossRef
• Growth differentiation factor 15 (GDF-15) in endocrinology
  Pedro Iglesias, Ramona A. Silvestre, Juan J. Díez
  Endocrine.2023; 81(3): 419.     CrossRef
• Identification of biomarkers for glycaemic deterioration in type 2 diabetes
  Roderick C. Slieker, Louise A. Donnelly, Elina Akalestou, Livia Lopez-Noriega, Rana Melhem, Ayşim Güneş, Frederic Abou Azar, Alexander Efanov, Eleni Georgiadou, Hermine Muniangi-Muhitu, Mahsa Sheikh, Giuseppe N. Giordano, Mikael Åkerlund, Emma Ahlqvist, A
  Nature Communications.2023;[Epub]     CrossRef
• Metabolic syndrome and Growth Differentiation Factor 15 in older adults
  Adrián Carballo-Casla, Esther García-Esquinas, Antonio Buño-Soto, Ellen A. Struijk, Esther López-García, Fernando Rodríguez-Artalejo, Rosario Ortolá
  GeroScience.2022; 44(2): 867.     CrossRef
• Associations between GDF15 Levels and Pre-Diabetes in Non-Obese Subjects
  Hao-Chang Hung, Hung-Tsung Wu, Ching-Han Lin, Hsuan-Wen Chou, Horng-Yih Ou, Chih-Jen Chang
  Journal of Investigative Medicine.2022; 70(1): 79.     CrossRef
• Growth Differentiation Factor-15 as a Biomarker of Obese Pre-diabetes and Type 2 Diabetes Mellitus in Indian Subjects: A Case-control Study
  Dipayan Roy, Purvi Purohit, Anupama Modi, Manoj Khokhar, Ravindra Kumar Gayaprasad Shukla, Ramkaran Chaudhary, Shrimanjunath Sankanagoudar, Praveen Sharma
  Current Diabetes Reviews.2022;[Epub]     CrossRef
• Growth Differentiation Factor 15 Protects SH-SY5Y Cells From Rotenone-Induced Toxicity by Suppressing Mitochondrial Apoptosis
  Peizheng Li, Hongbo Lv, Bohan Zhang, Ruonan Duan, Xiufang Zhang, Pengfei Lin, Chengyuan Song, Yiming Liu
  Frontiers in Aging Neuroscience.2022;[Epub]     CrossRef
• GDF-15 as a Therapeutic Target of Diabetic Complications Increases the Risk of Gallstone Disease: Mendelian Randomization and Polygenic Risk Score Analysis
  Lili Yu, Yajing Zhou, Lijuan Wang, Xuan Zhou, Jing Sun, Jiarui Xiao, Xiaolin Xu, Susanna C. Larsson, Shuai Yuan, Xue Li
  Frontiers in Genetics.2022;[Epub]     CrossRef
• Sex-specific modulation of circulating growth differentiation factor-15 in patients with type 2 diabetes and/or obesity
  Mohamed Asrih, Flore Sinturel, Richard Dubos, Idris Guessous, Zoltan Pataky, Charna Dibner, François R Jornayvaz, Karim Gariani
  Endocrine Connections.2022;[Epub]     CrossRef
• Raised circulating soluble growth differentiation factor 15 is negatively associated with testosterone level in hypogonadic men with type 2 diabetes
  Yufeng Mei, Yongnan Lyu, Juan Le, Di Li, Hang Liu, Zhiming Zhao, Yan Li
  Diabetes/Metabolism Research and Reviews.2022;[Epub]     CrossRef
• NCAM1 and GDF15 are biomarkers of Charcot-Marie-Tooth disease in patients and mice
  Matthew J Jennings, Alexia Kagiava, Leen Vendredy, Emily L Spaulding, Marina Stavrou, Denisa Hathazi, Anika Grüneboom, Vicky De Winter, Burkhard Gess, Ulrike Schara, Oksana Pogoryelova, Hanns Lochmüller, Christoph H Borchers, Andreas Roos, Robert W Burges
  Brain.2022; 145(11): 3999.     CrossRef
• Metformin and growth differentiation factor 15 (GDF15) in type 2 diabetes mellitus: A hidden treasure
  Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb, Athanasios Alexiou, Marios Papadakis, Eman Hassan Nadwa, Sarah M. Albogami, Mohammed Alorabi, Hebatallah M. Saad, Gaber El‐Saber Batiha
  Journal of Diabetes.2022; 14(12): 806.     CrossRef
• GDF15 is an exercise-induced hepatokine regulated by glucagon and insulin in humans
  Peter Plomgaard, Jakob S. Hansen, Logan K. Townsend, Anders Gudiksen, Niels H. Secher, Jens O. Clemmesen, Rene K. Støving, Jens P. Goetze, David C. Wright, Henriette Pilegaard
  Frontiers in Endocrinology.2022;[Epub]     CrossRef
• A study of serum growth differentiation factor 15 in Indian women with and without gestational diabetes mellitus in the third trimester of pregnancy and its association with pro-inflammatory markers and glucose metabolism
  Sudipta Banerjee, Rana Bhattacharjee, Amitabh Sur, Pieu Adhikary, Subhankar Chowdhury
  Diabetology International.2021; 12(3): 254.     CrossRef
• Growth Differentiation Factor 15 is a Cancer Cell-Induced Mitokine That Primes Thyroid Cancer Cells for Invasiveness
  Yea Eun Kang, Jin Man Kim, Mi Ae Lim, Seong Eun Lee, Shinae Yi, Jung Tae Kim, Chan Oh, Lihua Liu, Yanli Jin, Seung-Nam Jung, Ho-Ryun Won, Jae Won Chang, Jeong Ho Lee, Hyun Jung Kim, Hyun Yong Koh, Sangmi Jun, Sun Wook Cho, Minho Shong, Bon Seok Koo
  Thyroid.2021; 31(5): 772.     CrossRef
• The GDF15-GFRAL Pathway in Health and Metabolic Disease: Friend or Foe?
  Samuel N. Breit, David A. Brown, Vicky Wang-Wei Tsai
  Annual Review of Physiology.2021; 83(1): 127.     CrossRef
• Associations of GDF-15 and GDF-15/adiponectin ratio with odds of type 2 diabetes in the Chinese population
  Xiaoying Wu, Wenting Xuan, Lili You, Hong Lian, Feng Li, Xiaoyun Zhang, Qingyu Chen, Kan Sun, Chaogang Chen, Mingtong Xu, Yan Li, Li Yan, Xiuwei Zhang, Meng Ren
  Endocrine.2021; 72(2): 423.     CrossRef
• Decreased serum growth differentiation factor 15 levels after lifestyle intervention in patients with newly diagnosed type 2 diabetes mellitus
  Xingxing He, Jiaorong Su, Xiaojing Ma, Jingyi Lu, Yufei Wang, Jun Yin, Yuqian Bao, Gang Hu, Jian Zhou
  Obesity Medicine.2021; 24: 100345.     CrossRef
• The anti-diabetic effects of NAG-1/GDF15 on HFD/STZ-induced mice
  Pattawika Lertpatipanpong, Jaehak Lee, Ilju Kim, Thomas Eling, Seung Yeon Oh, Je Kyung Seong, Seung Joon Baek
  Scientific Reports.2021;[Epub]     CrossRef
• The Regulation of Circulating Hepatokines by Fructose Ingestion in Humans
  Michael M Richter, Peter Plomgaard
  Journal of the Endocrine Society.2021;[Epub]     CrossRef
• GDF15: emerging biology and therapeutic applications for obesity and cardiometabolic disease
  Dongdong Wang, Emily A. Day, Logan K. Townsend, Djordje Djordjevic, Sebastian Beck Jørgensen, Gregory R. Steinberg
  Nature Reviews Endocrinology.2021; 17(10): 592.     CrossRef
• High Fat, High Sugar Diet and DJOS Bariatric Surgery Influence Plasma Levels of Fetuin-B, Growth Differentiation Factor-15, and Pentraxin 3 in Diet-Induced Obese Sprague–Dawley Rats
  Jakub Poloczek, Monika Tarnawska, Elżbieta Chełmecka, Piotr Łaszczyca, Janusz Gumprecht, Dominika Stygar
  Nutrients.2021; 13(10): 3632.     CrossRef
• Serum growth differentiation factor 15 level is associated with muscle strength and lower extremity function in older patients with cardiometabolic disease
  Kazuhito Oba, Joji Ishikawa, Yoshiaki Tamura, Yasunori Fujita, Masafumi Ito, Ai Iizuka, Yoshinori Fujiwara, Remi Kodera, Ayumi Toba, Kenji Toyoshima, Yuko Chiba, Seijiro Mori, Masashi Tanaka, Hideki Ito, Kazumasa Harada, Atsushi Araki
  Geriatrics & Gerontology International.2020; 20(10): 980.     CrossRef
• Growth differentiation factor 15 (GDF-15) is a potential biomarker of both diabetic kidney disease and future cardiovascular events in cohorts of individuals with type 2 diabetes: a proteomics approach
  Axel C. Carlsson, Christoph Nowak, Lars Lind, Carl Johan Östgren, Fredrik H. Nyström, Johan Sundström, Juan Jesus Carrero, Ulf Riserus, Erik Ingelsson, Tove Fall, Johan Ärnlöv
  Upsala Journal of Medical Sciences.2020; 125(1): 37.     CrossRef
• Elevated Plasma Growth and Differentiation Factor 15 Is Associated With Slower Gait Speed and Lower Physical Performance in Healthy Community-Dwelling Adults
  Richard D Semba, Marta Gonzalez-Freire, Toshiko Tanaka, Angelique Biancotto, Pingbo Zhang, Michelle Shardell, Ruin Moaddel, Luigi Ferrucci, Anne Newman
  The Journals of Gerontology: Series A.2020; 75(1): 175.     CrossRef
• Circulating Cardiac Biomarkers in Diabetes Mellitus: A New Dawn for Risk Stratification—A Narrative Review
  Alexander E. Berezin, Alexander A. Berezin
  Diabetes Therapy.2020; 11(6): 1271.     CrossRef
• Deterioration of Sleep Quality According to Glycemic Status
  Myung Haeng Hur, Mi-Kyoung Lee, Kayeon Seong, Jun Hwa Hong
  Diabetes & Metabolism Journal.2020; 44(5): 679.     CrossRef
• Effects of plant and animal high protein diets on immune-inflammatory biomarkers: A 6-week intervention trial
  Mariya Markova, Liselot Koelman, Silke Hornemann, Olga Pivovarova, Stephanie Sucher, Juergen Machann, Natalia Rudovich, Ralph Thomann, Rosemarie Schneeweiss, Sascha Rohn, Andreas F.H. Pfeiffer, Krasimira Aleksandrova
  Clinical Nutrition.2020; 39(3): 862.     CrossRef
• Effect of sleeve gastrectomy on plasma growth differentiation factor-15 (GDF15) in human
  Ponnie Robertlee Dolo, Libin Yao, Peng Peng Liu, Jason Widjaja, Song Meng, Chao Li, Xiaocheng Zhu
  The American Journal of Surgery.2020; 220(3): 725.     CrossRef
• Prognostication of clinical outcomes in diabetes mellitus: Emerging role of cardiac biomarkers
  Alexander E. Berezin
  Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2019; 13(2): 995.     CrossRef
• Effect of bariatric surgery on plasma GDF15 in humans
  Maximilian Kleinert, Kirstine N. Bojsen-Møller, Nils B. Jørgensen, Maria S. Svane, Christoffer Martinussen, Bente Kiens, Jørgen F.P. Wojtaszewski, Sten Madsbad, Erik A. Richter, Christoffer Clemmensen
  American Journal of Physiology-Endocrinology and Metabolism.2019; 316(4): E615.     CrossRef
• Regulation of Systemic Glucose Homeostasis by T Helper Type 2 Cytokines
  Yea Eun Kang, Hyun Jin Kim, Minho Shong
  Diabetes & Metabolism Journal.2019; 43(5): 549.     CrossRef
• GDF15 reflects beta cell function in obese patients independently of the grade of impairment of glucose metabolism
  M.H. Schernthaner-Reiter, B.K. Itariu, M. Krebs, M. Promintzer-Schifferl, T.M. Stulnig, A. Tura, C.H. Anderwald, M. Clodi, B. Ludvik, G. Pacini, A. Luger, G. Vila
  Nutrition, Metabolism and Cardiovascular Diseases.2019; 29(4): 334.     CrossRef
• Growth differentiation factor 15: A novel biomarker with high clinical potential
  Stéphanie Desmedt, Valérie Desmedt, Leen De Vos, Joris R. Delanghe, Reinhart Speeckaert, Marijn M. Speeckaert
  Critical Reviews in Clinical Laboratory Sciences.2019; 56(5): 333.     CrossRef
• Hepatokines—a novel group of exercise factors
  Cora Weigert, Miriam Hoene, Peter Plomgaard
  Pflügers Archiv - European Journal of Physiology.2019; 471(3): 383.     CrossRef
• Association between MIC-1 and Type 2 Diabetes: A Combined Analysis
  Jianan Lu, Yue Zhang, Xingxuan Dong, Jiawen Lu, Chen Zhang, Jieyu Liu, Qingzhou Yu, Haoyue Teng, Qingkui Yao, Jieyun Yin, Liqiang Qin
  Disease Markers.2019; 2019: 1.     CrossRef
• The mitochondrial unfolded protein response and mitohormesis: a perspective on metabolic diseases
  Hyon-Seung Yi, Joon Young Chang, Minho Shong
  Journal of Molecular Endocrinology.2018; 61(3): R91.     CrossRef
• Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases
  Ana Luisa Cardoso, Adelaide Fernandes, Juan Antonio Aguilar-Pimentel, Martin Hrabě de Angelis, Joana Ribeiro Guedes, Maria Alexandra Brito, Saida Ortolano, Giovambattista Pani, Sophia Athanasopoulou, Efstathios S. Gonos, Markus Schosserer, Johannes Grilla
  Ageing Research Reviews.2018; 47: 214.     CrossRef
• Serum Meteorin-like protein levels decreased in patients newly diagnosed with type 2 diabetes
  Ju Hee Lee, Yea Eun Kang, Ji Min Kim, Sorim Choung, Kyong Hye Joung, Hyun Jin Kim, Bon Jeong Ku
  Diabetes Research and Clinical Practice.2018; 135: 7.     CrossRef
• Growth differentiation factor 15 predicts advanced fibrosis in biopsy‐proven non‐alcoholic fatty liver disease
  Bo Kyung Koo, Sung Hee Um, Dong Soo Seo, Sae Kyung Joo, Jeong Mo Bae, Jeong Hwan Park, Mee Soo Chang, Jung Ho Kim, Jieun Lee, Won‐Il Jeong, Won Kim
  Liver International.2018; 38(4): 695.     CrossRef
• Serum Growth Differentiation Factor 15 in Parkinson Disease
  Xiaomei Yao, Dong Wang, Lei Zhang, Lingling Wang, Zhenxiang Zhao, Si Chen, Xiaotang Wang, Tao Yue, Yiming Liu
  Neurodegenerative Diseases.2017; 17(6): 251.     CrossRef
• GDF15 deficiency exacerbates chronic alcohol- and carbon tetrachloride-induced liver injury
  Hyo Kyun Chung, Jung Tae Kim, Hyeon-Woo Kim, Minjoo Kwon, So Yeon Kim, Minho Shong, Koon Soon Kim, Hyon-Seung Yi
  Scientific Reports.2017;[Epub]     CrossRef
• Growth differentiation factor 15 as a predictor of adverse renal outcomes in patients with immunoglobulin A nephropathy
  Ki R. Na, Yoo H. Kim, Hyo K. Chung, Min‐Kyung Yeo, Young R. Ham, Jin Y. Jeong, Koon S. Kim, Kang W. Lee, Dae E. Choi
  Internal Medicine Journal.2017; 47(12): 1393.     CrossRef
• GDF15 contributes to radiation-induced senescence through the ROS-mediated p16 pathway in human endothelial cells
  Hyejin Park, Chun-Ho Kim, Jae-Hoon Jeong, Myungjin Park, Kwang Seok Kim
  Oncotarget.2016; 7(9): 9634.     CrossRef
• GDF-15 and Hepcidin Levels in Nonanemic Patients with Impaired Glucose Tolerance
  Mehmet Muhittin Yalcin, Alev Eroglu Altinova, Mujde Akturk, Ozlem Gulbahar, Emre Arslan, Damla Ors Sendogan, Ilhan Yetkin, Fusun Balos Toruner
  Journal of Diabetes Research.2016; 2016: 1.     CrossRef
• Cardiac‐Secreted Factors as Peripheral Metabolic Regulators and Potential Disease Biomarkers
  Colleen M. Dewey, Kathryn M. Spitler, Jessica M. Ponce, Duane D. Hall, Chad E. Grueter
  Journal of the American Heart Association.2016;[Epub]     CrossRef
• Determinants of growth differentiation factor 15 in patients with stable and acute coronary artery disease. A prospective observational study
  Serdar Farhan, Matthias K. Freynhofer, Ivan Brozovic, Veronika Bruno, Birgit Vogel, Ioannis Tentzeris, Sabina Baumgartner-Parzer, Kurt Huber, Alexandra Kautzky-Willer
  Cardiovascular Diabetology.2016;[Epub]     CrossRef
• Effect of Atorvastatin on Growth Differentiation Factor-15 in Patients with Type 2 Diabetes Mellitus and Dyslipidemia
  Ji Min Kim, Min Kyung Back, Hyon-Seung Yi, Kyong Hye Joung, Hyun Jin Kim, Bon Jeong Ku
  Diabetes & Metabolism Journal.2016; 40(1): 70.     CrossRef
• Association between Growth Differentiation Factor 15 (GDF15) and Cardiovascular Risk in Patients with Newly Diagnosed Type 2 Diabetes Mellitus
  Min Young Shin, Ji Min Kim, Yea Eun Kang, Min Kyeong Kim, Kyong Hye Joung, Ju Hee Lee, Koon Soon Kim, Hyun Jin Kim, Bon Jeong Ku, Minho Shong
  Journal of Korean Medical Science.2016; 31(9): 1413.     CrossRef
• Comparison of Transcriptome Between Type 2 Diabetes Mellitus and Impaired Fasting Glucose
  Ying Cui, Wen Chen, Jinfeng Chi, Lei Wang
  Medical Science Monitor.2016; 22: 4699.     CrossRef
• Letter: GDF15 Is a Novel Biomarker for Impaired Fasting Glucose (Diabetes Metab J2014;38:472-9)
  Bo Kyung Koo
  Diabetes & Metabolism Journal.2015; 39(1): 82.     CrossRef
• Relationship between hepcidin and GDF15 in anemic patients with type 2 diabetes without overt renal impairment
  Jun Hwa Hong, Yeon-Kyung Choi, Byong-Keol Min, Kang Seo Park, Kayeon Seong, In Kyu Lee, Jung Guk Kim
  Diabetes Research and Clinical Practice.2015; 109(1): 64.     CrossRef
• Response: GDF15 Is a Novel Biomarker for Impaired Fasting Glucose (Diabetes Metab J2014;38:472-9)
  Jun Hwa Hong, Bon Jeong Ku, Minho Shong
  Diabetes & Metabolism Journal.2015; 39(1): 84.     CrossRef
• Is GDF15 a Novel Biomarker to Predict the Development of Prediabetes or Diabetes?
  Kyu Yeon Hur
  Diabetes & Metabolism Journal.2014; 38(6): 437.     CrossRef

Citations

Citations to this article as recorded by  

• More Rapid Bone Mineral Density Loss in Older Men With Diabetes: The Osteoporotic Fractures in Men (MrOS) Study
  Flavia Tramontana, Nicola Napoli, Stephanie Litwack-Harrison, Douglas C Bauer, Eric S Orwoll, Jane A Cauley, Elsa S Strotmeyer, Ann V Schwartz
  The Journal of Clinical Endocrinology & Metabolism.2024; 109(12): e2283.     CrossRef
• Scientometric analysis of global publications on prediabetes and osteoporosis: 1994–2023
  Raju Vaishya, Brij Mohan Gupta, Ghouse Modin Nabeesab Mamdapur, Anoop Misra, Abhishek Vaish
  Journal of Clinical Orthopaedics and Trauma.2024; 54: 102493.     CrossRef
• Prediabetes and skeletal health
  Catherine Lindsay, Albert Shieh
  Current Opinion in Endocrinology, Diabetes & Obesity.2023; 30(4): 200.     CrossRef
• Serum levels of sclerostin in prediabetes and its correlation with bone mineral density
  Ajay Chauhan, Manoj Kumar Bhakhar, Parul Goyal
  Journal of Family Medicine and Primary Care.2023; 12(11): 2702.     CrossRef
• The risk of hip fractures in individuals over 50 years old with prediabetes and type 2 diabetes – A longitudinal nationwide population-based study
  Ho Youn Park, Kyoungdo Han, Youngwoo Kim, Yoon Hwan Kim, Yoo Joon Sur
  Bone.2021; 142: 115691.     CrossRef
• Bone health in diabetes and prediabetes
  Silvia Costantini, Caterina Conte
  World Journal of Diabetes.2019; 10(8): 421.     CrossRef
• Bone mineral density in obese children with prediabetes
  Ala ÜSTYOL, Mehmet Emre ATABEK
  Ege Tıp Dergisi.2018; 57(2): 94.     CrossRef
• The Prevalence of Osteopenia and Osteoporosis Among Malaysian Type 2 Diabetic Patients Using Quantitative Ultrasound Densitometer
  Shaymaa Abdalwahed Abdulameer, Mohanad Naji Sahib, Syed Azhar Syed Sulaiman
  The Open Rheumatology Journal.2018; 12(1): 50.     CrossRef
• An association between bone mineral density and anabolic hormones in middle-aged and elderly men with prediabetes
  Michał Rabijewski, Lucyna Papierska, Paweł Piątkiewicz
  The Aging Male.2017; : 1.     CrossRef
• Amplification of transcutaneous and percutaneous bone-conduction devices with a test-band in an induced model of conductive hearing loss
  Marn Joon Park, Jae Ryung Lee, Chan Joo Yang, Myung Hoon Yoo, In Suk Jin, Chi Ho Choi, Hong Ju Park
  International Journal of Audiology.2016; 55(11): 653.     CrossRef
• Osteoporosis in Men with Diabetes Mellitus
  Claire Issa, Mira S. Zantout, Sami T. Azar
  Journal of Osteoporosis.2011; 2011: 1.     CrossRef
• Response: Bone Mineral Density in Prediabetic Men (Korean Diabetes J 2010;34:294-302)
  Ju Hee Lee, Hyun Jin Kim, Bon Jeong Ku
  Korean Diabetes Journal.2010; 34(6): 386.     CrossRef
• Letter: Bone Mineral Density in Prediabetic Men (Korean Diabetes J 2010;34:294-302)
  Chul-Hee Kim
  Korean Diabetes Journal.2010; 34(6): 384.     CrossRef