Diabetes & Metabolism Journal

Mijin Kim (Kim M)

2 Articles

Pharmacotherapy
Use of Glucagon-Like Peptide-1 Receptor Agonists Does Not Increase the Risk of Cancer in Patients with Type 2 Diabetes Mellitus: Mijin Kim, Seung Chan Kim, Jinmi Kim, Bo Hyun Kim; Diabetes Metab J. 2025;49(1):49-59. Published online October 24, 2024; DOI: https://doi.org/10.4093/dmj.2024.0105

1,056 View
116 Download

Abstract PDF Supplementary Material PubReader ePub: Background
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are increasingly used for the treatment of type 2 diabetes mellitus (T2DM) given their extra-pancreatic effects. However, there are concerns about carcinogenesis in the pancreas and thyroid gland. We aimed to evaluate the site-specific incidence of cancer in patients with T2DM-treated GLP-1 RAs using a nationwide cohort.
Methods
This study included data obtained from the Korean National Health Insurance Service (between 2004 and 2021). The primary outcome was newly diagnosed cancer, and the median follow-up duration for all participants was 8 years.
Results
After propensity score matching, 7,827 participants were analyzed; 2,609 individuals each were included in the GLP-1 RA, diabetes mellitus (DM) control, and non-DM control groups. The incidence rate ratio (IRR) of subsequent cancer in patients with T2DM was 1.73, which was higher than that of individuals without DM, and it increased in both men and women. Analysis of patients with T2DM showed no increased cancer risk associated with the use of GLP-1 RA, and similar results were observed in both men and women. The IRRs of pancreatic cancer (0.74), thyroid cancer (1.32), and medullary thyroid cancer (0.34) did not significantly increase in the GLP-1 RA group compared with those in the DM control group.
Conclusion
There was a 73% higher risk of cancer in patients with T2DM compared with the general population. However, among patients with T2DM, there was no association between the use of GLP-1 RAs and new-onset cancers, including pancreatic and medullary thyroid cancers.

Obesity and Metabolic Syndrome
The Relationship between Thyroid Function and Different Obesity Phenotypes in Korean Euthyroid Adults: Jeong Mi Kim, Bo Hyun Kim, Hyungi Lee, Eun Heui Kim, Mijin Kim, Jong Ho Kim, Yun Kyung Jeon, Sang Soo Kim, In Joo Kim, Yong Ki Kim; Diabetes Metab J. 2019;43(6):867-878. Published online April 3, 2019; DOI: https://doi.org/10.4093/dmj.2018.0130

7,198 View
79 Download
20 Web of Science
19 Crossref

Abstract PDF Supplementary Material PubReader

Background

Thyroid disease and metabolic syndrome are both associated with cardiovascular disease. The aim of this study was to investigate the correlation between thyroid hormones and obesity sub-phenotypes using nationwide data from Korea, a country known to be iodine replete.

Methods

This study was based on data obtained from the sixth Korea National Health and Nutrition Examination Survey, administered from 2013 to 2015. A total of 13,873 participants aged ≥19 years were included, and classified into four groups: metabolically healthy non-obesity (MHNO), metabolically healthy obesity (MHO), metabolically unhealthy non-obesity (MUNO), and metabolically unhealthy obesity (MUO) by body fat on the basis of body mass index and metabolic health.

Results

At baseline, serum free thyroxine (fT4) values were significantly higher in the MHNO phenotype (MHNO, 1.27±0.01 ng/dL; MHO, 1.25±0.01 ng/dL; MUNO, 1.24±0.01 ng/dL; MUO, 1.24±0.01 ng/dL, P<0.001) in total study population. However, this significant association no longer remained after adjustment for age, urine iodine concentration, and smoking (P=0.085). After adjustment for confounders, statistically significant association was observed between lower thyroid stimulating hormone (TSH) and MHNO phenotype (P=0.044). In men participants (not women), higher fT4 values were significantly associated with MHNO phenotype (P<0.001). However, no significant association was observed between thyroid function (TSH or fT4) and obesity phenotypes in groups classified by age (cutoff age of 55 years).

Conclusion

Although there was a difference by age and sex, we found that the decrease of TSH and the increase of fT4 values were associated with MHNO.

Citations

Citations to this article as recorded by

Causal association between obesity and hypothyroidism: a two-sample bidirectional Mendelian randomization study
Yingkun Qiu, Qinyu Liu, Yinghua Luo, Jiadi Chen, Qingzhu Zheng, Yuping Xie, Yingping Cao
Frontiers in Endocrinology.2024;[Epub] CrossRef
Exploring the diagnostic performance of machine learning in prediction of metabolic phenotypes focusing on thyroid function
Hyeong Jun Ahn, Kyle Ishikawa, Min-Hee Kim, Vijayalakshmi Kakulapati
PLOS ONE.2024; 19(6): e0304785. CrossRef
Association between thyroid hormone resistance and obesity: a cross‐sectional study and mouse stimulation test
Zhihui Wang, Huimin Yu, Kai Wang, Junming Han, Yongfeng Song
Obesity.2024; 32(8): 1483. CrossRef
Association between sensitivity to thyroid hormone indices and type 2 diabetic microvascular complications in euthyroid patients
Junping Zhang, Zhanpeng Luo, Jie Zhang, Ruohao Zhang, Xinnan Liu, Jinying Wang, Shasha He, Jiao Wang, Dandan Chen, Cuiyun Chen, Jiancheng Wang, Shen Chen, Jixiong Xu
Scientific Reports.2024;[Epub] CrossRef
Association between thyroid function and obesity phenotypes in healthy euthyroid individuals: an investigation based on Tehran Thyroid Study
Behnaz Abiri, Amirhossein Ramezani Ahmadi, Maryam Mahdavi, Atieh Amouzegar, Majid Valizadeh
European Journal of Medical Research.2023;[Epub] CrossRef
Characteristics of the metabolically unhealthy phenotype in menopausal resistance training practitioners
Ana Carla Leocadio de Magalhaes, Vilma Fernandes Carvalho, Sabrina Pereira da Cruz, Andréa Ramalho
Nutrición Hospitalaria.2023;[Epub] CrossRef
A systematic review and meta-analysis investigating the relationship between metabolic syndrome and the incidence of thyroid diseases
Heba Alwan, Valerie Aponte Ribero, Orestis Efthimiou, Cinzia Del Giovane, Nicolas Rodondi, Leonidas Duntas
Endocrine.2023; 84(2): 320. CrossRef
Higher Sensitivity to Thyroid Hormones May Be Linked to Maintaining the Healthy Metabolic Condition in People with Obesity: New Insight from NHANES
Ying-shan Liu, Xiao-cong Liu, Jian Kuang, Hai-xia Guan
Obesity Facts.2023; 16(5): 497. CrossRef
Is there a link between obesity phenotype and thyroid diseases? A mini-review of current concepts
Ewa Malwina Milewska-Kobos, Ewelina Szczepanek-Parulska, Marek Ruchala
Postępy Higieny i Medycyny Doświadczalnej.2023; 77(1): 107. CrossRef
Sex-specific Association of Subclinical Hypothyroidism With Incident Metabolic Syndrome: A Population-based Cohort Study
Zhiyuan Wu, Yue Jiang, Di Zhou, Shuo Chen, Yu Zhao, Haiping Zhang, Yue Liu, Xia Li, Wei Wang, Jingbo Zhang, Xiaoping Kang, Lixin Tao, Bo Gao, Xiuhua Guo
The Journal of Clinical Endocrinology & Metabolism.2022; 107(6): e2365. CrossRef
Determination of age and sex specific TSH and FT4 reference limits in overweight and obese individuals in an iodine-replete region: Tehran Thyroid Study (TTS)
Hengameh Abdi, Bita Faam, Safoora Gharibzadeh, Ladan Mehran, Maryam Tohidi, Fereidoun Azizi, Atieh Amouzegar
Endocrine Research.2021; 46(1): 37. CrossRef
Association of Metabolic Obesity Phenotypes and Total Testosterone in Chinese Male Population
Luna Liu, Shuang Liu, Qianmei Song, Dandan Luo, Yu Su, Xiangyu Qi, Qian Wang, Jing Ning, Youyuan Lv, Qingbo Guan
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2021; Volume 14: 399. CrossRef
Insulin Resistance in Association with Thyroid Function, Psychoemotional State, and Cardiovascular Risk Factors
Nijole Kazukauskiene, Aurelija Podlipskyte, Giedrius Varoneckas, Narseta Mickuviene
International Journal of Environmental Research and Public Health.2021; 18(7): 3388. CrossRef
Association between different obesity phenotypes and hypothyroidism: a study based on a longitudinal health management cohort
Yupeng Wang, Haiyan Lin, Qihang Li, Liying Guan, Meng Zhao, Fang Zhong, Jing Liu, Zhongshang Yuan, Honglin Guo, Yongfeng Song, Ling Gao, Jiajun Zhao
Endocrine.2021; 72(3): 688. CrossRef
Causal Association Between Serum Thyrotropin and Obesity: A Bidirectional, Mendelian Randomization Study
Xichang Wang, Xiaotong Gao, Yutong Han, Fan Zhang, Zheyu Lin, Hong Wang, Weiping Teng, Zhongyan Shan
The Journal of Clinical Endocrinology & Metabolism.2021; 106(10): e4251. CrossRef
Effect of body mass index on peak growth hormone level after growth hormone stimulation test in children with short stature
Na Yeong Lee, Sung Eun Kim, Seulki Kim, Moon Bae Ahn, Shin Hee Kim, Won Kyoung Cho, Kyoung Soon Cho, Min Ho Jung, Byung-Kyu Suh
Annals of Pediatric Endocrinology & Metabolism.2021; 26(3): 192. CrossRef
Interaction effect of obesity and thyroid autoimmunity on the prevalence of hyperthyrotropinaemia
Xiaoyong Guo, Zhao He, Shanshan Shao, Yilin Fu, Dongmei Zheng, Lu Liu, Ling Gao, Liying Guan, Meng Zhao, Jiajun Zhao
Endocrine.2020; 68(3): 573. CrossRef
The role of thyroid hormone in metabolism and metabolic syndrome
Patrícia de Fátima dos Santos Teixeira, Patrícia Borges dos Santos, Carmen Cabanelas Pazos-Moura
Therapeutic Advances in Endocrinology and Metabolism.2020;[Epub] CrossRef
Characteristics of Serum Thyroid Hormones in Different Metabolic Phenotypes of Obesity
Xiaomin Nie, Xiaojing Ma, Yiting Xu, Yun Shen, Yufei Wang, Yuqian Bao
Frontiers in Endocrinology.2020;[Epub] CrossRef

Author index