Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal

Search
OPEN ACCESS

Author index

Page Path
HOME > Browse > Author index
Search
Mi Jeong Kang  (Kang MJ) 1 Article
Basic Research
Article image
Role of Intestinal Microbiota in Metabolism of Voglibose In Vitro and In Vivo
Mahesh Raj Nepal, Mi Jeong Kang, Geon Ho Kim, Dong Ho Cha, Ju-Hyun Kim, Tae Cheon Jeong
Diabetes Metab J. 2020;44(6):908-918.   Published online April 6, 2020
DOI: https://doi.org/10.4093/dmj.2019.0147
  • 6,346 View
  • 127 Download
  • 6 Web of Science
  • 6 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background

Voglibose, an α-glucosidase inhibitor, inhibits breakdown of complex carbohydrates into simple sugar units in intestine. Studies showed that voglibose metabolism in the liver might be negligible due to its poor intestinal absorption. Numerous microorganisms live in intestine and have several roles in metabolism and detoxification of various xenobiotics. Due to the limited information, the possible metabolism of voglibose by intestinal microbiota was investigated in vitro and in vivo.

Methods

For the in vitro study, different concentrations of voglibose were incubated with intestinal contents, prepared from both vehicle- and antibiotics-treated mice, to determine the decreased amount of voglibose over time by using liquid chromatography-mass spectrometry. Similarly, in vivo pharmacodynamic effect of voglibose was determined following the administration of voglibose and starch in vehicle- and antibiotic-pretreated non-diabetic and diabetic mice, by measuring the modulatory effects of voglibose on blood glucose levels.

Results

The in vitro results indicated that the remaining voglibose could be significantly decreased when incubated with the intestinal contents from normal mice compared to those from antibiotic-treated mice, which had less enzyme activities. The in vivo results showed that the antibiotic pretreatment resulted in reduced metabolism of voglibose. This significantly lowered blood glucose levels in antibiotic-pretreated mice compared to the control animals.

Conclusion

The present results indicate that voglibose would be metabolized by the intestinal microbiota, and that this metabolism might be pharmacodynamically critical in lowering blood glucose levels in mice.

Citations

Citations to this article as recorded by  
  • Pharmacomicrobiomics and type 2 diabetes mellitus: A novel perspective towards possible treatment
    Liyang Jia, Shiqiong Huang, Boyu Sun, Yongguang Shang, Chunsheng Zhu
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Phenolics from endophytic fungi as natural α-glucosidase inhibitors: A comprehensive review
    Muhammad Imran Tousif, Saba Tauseef, Sadeer Nabeelah, Jugreet Sharmeen, Gokhan Zengin, Lesetja Legoabe, Muhammad Imran, Mohamad Fawzi Mahomoodally
    Journal of Molecular Structure.2023; 1291: 135852.     CrossRef
  • Ligand-targeted fishing of α-glucosidase inhibitors from Tribulus terrestris L. based on chitosan-functionalized multi-walled carbon nanotubes with immobilized α-glucosidase
    Xin Meng, Hou Zong, Zhong Zheng, Junpeng Xing, Zhiqiang Liu, Fengrui Song, Shu Liu
    Analytical and Bioanalytical Chemistry.2023; 415(14): 2677.     CrossRef
  • Isolation, structure elucidation, and biological activities of sesquiterpenes and phthalides from two edible mushrooms Pleurotus species
    Jewel C De Padua, Emi Fukushima-Sakuno, Kotomi Ueno, Thomas Edison E dela Cruz, Atsushi Ishihara
    Bioscience, Biotechnology, and Biochemistry.2023; 87(12): 1429.     CrossRef
  • Effects of Oral Glucose-Lowering Agents on Gut Microbiota and Microbial Metabolites
    Dongmei Wang, Jieying Liu, Liyuan Zhou, Qian Zhang, Ming Li, Xinhua Xiao
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • 18:0 Lyso PC, a natural product with potential PPAR-γ agonistic activity, plays hypoglycemic effect with lower liver toxicity and cardiotoxicity in db/db mice
    Yiming Ma, Xinyi Du, Dandan Zhao, Kegong Tang, Xiaona Wang, Shaoting Guo, Xiaobei Li, Song Mei, Na Sun, Jiaqi Liu, Chengyu Jiang
    Biochemical and Biophysical Research Communications.2021; 579: 168.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal
Close layer
TOP