- Obesity and Metabolic Syndrome
- Regulating Hypothalamus Gene Expression in Food Intake: Dietary Composition or Calorie Density?
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Mi Jang, So-Young Park, Yong-Woon Kim, Seung-Pil Jung, Jong-Yeon Kim
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Diabetes Metab J. 2017;41(2):121-127. Published online December 16, 2016
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DOI: https://doi.org/10.4093/dmj.2017.41.2.121
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Abstract
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- Background
The proportion of saturated fatty acids/unsaturated fatty acids in the diet seems to act as a physiological regulation on obesity, cardiovascular diseases, and diabetes. Differently composed fatty acid diets may induce satiety of the hypothalamus in different ways. However, the direct effect of the different fatty acid diets on satiety in the hypothalamus is not clear. MethodsThree experiments in mice were conducted to determine whether: different compositions of fatty acids affects gene mRNA expression of the hypothalamus over time; different types of fatty acids administered into the stomach directly affect gene mRNA expression of the hypothalamus; and fat composition changes in the diet affects gene mRNA expression of the hypothalamus. ResultsThe type of fat in cases of purified fatty acid administration directly into the stomach may cause changes of gene expressions in the hypothalamus. Gene expression by dietary fat may be regulated by calorie amount ingested rather than weight amount or type of fat. ConclusionTherefore, the calorie density factor of the diet in regulating hypothalamic gene in food intake may be detrimental, although the possibility of type of fat cannot be ruled out.
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Citations
Citations to this article as recorded by
- Prepartum fatty acid supplementation in sheep. III. Effect of eicosapentaenoic acid and docosahexaenoic acid during finishing on performance, hypothalamus gene expression, and muscle fatty acids composition in lambs1
Ana Cristina Carranza Martin, Danielle Nicole Coleman, Lyda Guadalupe Garcia, Cecilia C Furnus, Alejandro E Relling Journal of Animal Science.2018; 96(12): 5300. CrossRef - Acute anti‐obesity effects of intracerebroventricular 11β‐HSD1 inhibitor administration in diet‐induced obese mice
M. Seo, S. A. Islam, S.‐S. Moon Journal of Neuroendocrinology.2018;[Epub] CrossRef - Letter: Regulating Hypothalamus Gene Expression in Food Intake: Dietary Composition or Calorie Density? (Diabetes Metab J 2017;41:121-7)
Bo Kyung Koo Diabetes & Metabolism Journal.2017; 41(3): 223. CrossRef - Response: Regulating Hypothalamus Gene Expression in Food Intake: Dietary Composition or Calorie Density? (Diabetes Metab J2017;41:121-7)
Mi Jang, So-Young Park, Yong-Woon Kim, Seung-Pil Jung, Jong-Yeon Kim Diabetes & Metabolism Journal.2017; 41(3): 225. CrossRef
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