- Complications
- Impact of Gender on the Association between Low Serum Prolactin and Left Ventricular Mass in Subjects with Prediabetes
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Mervat M. El-Eshmawy, Enas M. Elkhamisy, Eman Elsayed, Shaheer Kamal
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Diabetes Metab J. 2017;41(3):195-204. Published online June 21, 2017
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DOI: https://doi.org/10.4093/dmj.2017.41.3.195
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- Background
Low circulating prolactin hormone was associated with increased risk for type 2 diabetes mellitus. An inverse association of serum prolactin with cardiac remodeling was also previously suggested. Thus, the first question arises whether low serum prolactin is associated with adverse cardiac remodeling in subjects with prediabetes and if so what the impact of gender is? Second, could serum prolactin be considered a predictor of cardiac morbidity in those subjects? This study was conducted to assess prolactin level variations in relation to echocardiographic indices of cardiac remodeling among adult men and women with prediabetes. MethodsThis cross sectional study enrolled 80 subjects with prediabetic; 40 men and 40 women. Anthropometric measurements, plasma glucose, lipid profile, homeostasis model assessment of insulin resistance, white blood cells count, prolactin and echocardiography were assessed. ResultsProlactin was significantly lower in men than in women with prediabetes. Left ventricular mass (LVM) was significantly higher in men than in women with prediabetes. The proportion of left ventricular hypertrophy (LVH) in men with prediabetes was 45% compared with 22.5% in women (P=0.03). We also found inverse independent associations of serum prolactin with LVM and LVH in men, but not in women. ConclusionIn prediabetes, physiologically low serum prolactin is an independent predictor of increased LVM and LVH in adult men, but not in women. Prolactin may be a potential diagnostic biomarker for cardiac remodeling in adult men with prediabetes.
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Citations
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- The influence of diabetes and prediabetes on left heart remodeling: A population-based study
Tan Li, Guangxiao Li, Xiaofan Guo, Zhao Li, Jun Yang, Yingxian Sun Journal of Diabetes and its Complications.2021; 35(2): 107771. CrossRef - The regulatory effect of bromocriptine on cardiac hypertrophy by prolactin and D2 receptor modulation
Karla Aidee Aguayo-Cerón, Claudia Camelia Calzada-Mendoza, Enrique Méndez-Bolaina, Rodrigo Romero-Nava, María Esther Ocharan-Hernández Clinical and Experimental Hypertension.2020; 42(7): 675. CrossRef - Serum Prolactin and Cardiac Remodeling in Subjects with Prediabetes
Jin Hwa Kim Diabetes & Metabolism Journal.2017; 41(3): 168. CrossRef
- Response: Subclinical Hypothyroidism Is Independently Associated with Microalbuminuria in a Cohort of Prediabetic Egyptian Adults (Diabetes Metab J 2013;37:450-7)
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Mervat M. El-Eshmawy, Hala A. Abd El-Hafez, Walaa Othman El Shabrawy, Ibrahim A. Abdel Aal
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Diabetes Metab J. 2014;38(1):85-86. Published online February 19, 2014
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DOI: https://doi.org/10.4093/dmj.2014.38.1.85
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- ЦУКРОВИЙ ДІАБЕТ 2 ТИПУ ТА ЗАХВОРЮВАННЯ ЩИТОПОДІБНОЇ ЗАЛОЗИ: ПОШУК СПІЛЬНИХ МЕХАНІЗМІВ
V. A. Musiienko, M. I. Marushchak Вісник медичних і біологічних досліджень.2020; (1): 74. CrossRef - Association between thyroid function and diabetic nephropathy in euthyroid subjects with type 2 diabetes mellitus: a cross-sectional study in China
Jian Wang, Huiqin Li, Mingjuan Tan, Gu Gao, Ying Zhang, Bo Ding, Xiaofei Su, Xiaocen Kong, Jianhua Ma Oncotarget.2019; 10(2): 88. CrossRef - Poor glycemic control is associated with the risk of subclinical hypothyroidism in patients with type 2 diabetes mellitus
Jae Ho Cho, Ho Jin Kim, Jun Ho Lee, Il Rae Park, Jun Sung Moon, Ji Sung Yoon, In-Kyu Lee, Kyu Chang Won, Hyoung Woo Lee The Korean Journal of Internal Medicine.2016; 31(4): 703. CrossRef
- Subclinical Hypothyroidism Is Independently Associated with Microalbuminuria in a Cohort of Prediabetic Egyptian Adults
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Mervat M. El-Eshmawy, Hala A. Abd El-Hafez, Walaa Othman El Shabrawy, Ibrahim A. Abdel Aal
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Diabetes Metab J. 2013;37(6):450-457. Published online December 12, 2013
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DOI: https://doi.org/10.4093/dmj.2013.37.6.450
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Recent evidence has suggested an association between subclinical hypothyroidism (SCH) and microalbuminuria in patients with type 2 diabetes. However, whether SCH is related to microalbuminuria among subjects with prediabetes has not been studied. Thus, we evaluated the association between SCH and microalbuminuria in a cohort of prediabetic Egyptian adults. MethodsA total of 147 prediabetic subjects and 150 healthy controls matched for age and sex were enrolled in this study. Anthropometric measurements, plasma glucose, lipid profile, homeostasis model assessment of insulin resistance (HOMA-IR), thyroid stimulating hormone (TSH), free thyroxine, triiodothyronine levels, and urinary albumin-creatinine ratio (UACR) were assessed. ResultsThe prevalence of SCH and microalbuminuria in the prediabetic subjects was higher than that in the healthy controls (16.3% vs. 4%, P<0.001; and 12.9% vs. 5.3%, P=0.02, respectively). Prediabetic subjects with SCH were characterized by significantly higher HOMA-IR, TSH levels, UACR, and prevalence of microalbuminuria than those with euthyroidism. TSH level was associated with total cholesterol (P=0.05), fasting insulin (P=0.01), HOMA-IR (P=0.01), and UACR (P=0.005). UACR was associated with waist circumference (P=0.01), fasting insulin (P=0.05), and HOMA-IR (P=0.02). With multiple logistic regression analysis, SCH was associated with microalbuminuria independent of confounding variables (β=2.59; P=0.01). ConclusionOur findings suggest that prediabetic subjects with SCH demonstrate higher prevalence of microalbuminuria than their non-SCH counterparts. SCH is also independently associated with microalbuminuria in prediabetic subjects. Screening and treatment for SCH may be warranted in those patients.
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