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Majken K. Jensen  (Jensen MK) 2 Articles
Metabolic Risk/Epidemiology
Plasma CD36 and Incident Diabetes: A Case-Cohort Study in Danish Men and Women
Yeli Wang, Jingwen Zhu, Sarah Aroner, Kim Overvad, Tianxi Cai, Ming Yang, Anne Tjønneland, Aase Handberg, Majken K. Jensen
Diabetes Metab J. 2020;44(1):134-142.   Published online October 18, 2019
DOI: https://doi.org/10.4093/dmj.2018.0273
  • 4,241 View
  • 70 Download
  • 2 Web of Science
  • 2 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   
Background

Membrane CD36 is a fatty acid transporter implicated in the pathogenesis of metabolic disease. We aimed to evaluate the association between plasma CD36 levels and diabetes risk and to examine if the association was independent of adiposity among Danish population.

Methods

We conducted a case-cohort study nested within the Danish Diet, Cancer and Health study among participants free of cardiovascular disease, diabetes and cancer and with blood samples and anthropometric measurements (height, weight, waist circumference, and body fat percentage) at baseline (1993 to 1997). CD36 levels were measured in 647 incident diabetes cases that occurred before December 2011 and a total of 3,515 case-cohort participants (236 cases overlap).

Results

Higher plasma CD36 levels were associated with higher diabetes risk after adjusting for age, sex and other lifestyle factors. The hazard ratio (HR) comparing high versus low tertile of plasma CD36 levels was 1.36 (95% confidence interval [CI], 1.00 to 1.86). However, the association lost its significance after further adjustment for different adiposity indices such as body mass index (HR, 1.23; 95% CI, 0.87 to 1.73), waist circumference (HR, 1.21; 95% CI, 0.88 to 1.68) or body fat percentage (HR, 1.20; 95% CI, 0.86 to 1.66). Moreover, raised plasma CD36 levels were moderately associated with diabetes risk among lean participants, but the association was not present among overweight/obese individuals.

Conclusion

Higher plasma CD36 levels were associated with higher diabetes risk, but the association was not independent of adiposity. In this Danish population, the association of CD36 with diabetes risk could be either mediated or confounded by adiposity.

Citations

Citations to this article as recorded by  
  • The Multifunctionality of CD36 in Diabetes Mellitus and Its Complications—Update in Pathogenesis, Treatment and Monitoring
    Kamila Puchałowicz, Monika Ewa Rać
    Cells.2020; 9(8): 1877.     CrossRef
  • The Role of CD36 in Type 2 Diabetes Mellitus: β-Cell Dysfunction and Beyond
    Jun Sung Moon, Udayakumar Karunakaran, Elumalai Suma, Seung Min Chung, Kyu Chang Won
    Diabetes & Metabolism Journal.2020; 44(2): 222.     CrossRef
Epidemiology
Plasma Fetuin-A Levels and Risk of Type 2 Diabetes Mellitus in A Chinese Population: A Nested Case-Control Study
Yeli Wang, Woon-Puay Koh, Majken K. Jensen, Jian-Min Yuan, An Pan
Diabetes Metab J. 2019;43(4):474-486.   Published online March 20, 2019
DOI: https://doi.org/10.4093/dmj.2018.0171
  • 4,538 View
  • 71 Download
  • 8 Web of Science
  • 8 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   
Background

Fetuin-A is a hepatokine that involved in the pathogenesis of insulin resistance. Previous epidemiological studies have found a positive association between blood fetuin-A and type 2 diabetes mellitus (T2DM) risk among Caucasians and African Americans. We aimed to investigate the prospective relationship between fetuin-A and T2DM in an Asian population for the first time.

Methods

A nested case-control study was established within a prospective cohort of Chinese living in Singapore. At blood collection (1999 to 2004), all participants were free of diagnosed T2DM and aged 50 to 79 years. At subsequent follow-up (2006 to 2010), 558 people reported to have T2DM and were classified as incident cases, and 558 controls were randomly chosen from the participants who did not develop T2DM to match with cases on age, sex, dialect group, and date of blood collection. Plasma fetuin-A levels were measured retrospectively in cases and controls using samples collected at baseline. Conditional logistic regression models were used to compute the odds ratio (OR) and 95% confidence interval (CI). Restricted cubic spline analysis was used to examine a potential non-linear association between fetuin-A levels and T2DM risk.

Results

Compared with those in the lowest fetuin-A quintile, participants in the highest quintile had a two-fold increased risk of developing T2DM (OR, 2.06; 95% CI, 1.21 to 3.51). A non-linear association was observed (P nonlinearity=0.005), where the association between fetuin-A levels and T2DM risk plateaued at plasma concentrations around 830 µg/mL.

Conclusion

There is a positive association between plasma fetuin-A levels and risk of developing T2DM in this Chinese population.

Citations

Citations to this article as recorded by  
  • Type 2 diabetes and gut health - Narrative review
    Janeline Lunghar, A. Thahira Banu
    International Journal of Noncommunicable Diseases.2024; 9(1): 4.     CrossRef
  • The predicted mechanisms and evidence of probiotics on type 2 diabetes mellitus (T2DM)
    Ousman Bajinka, Kodzovi Sylvain Dovi, Lucette Simbilyabo, Ishmail Conteh, Yurong Tan
    Archives of Physiology and Biochemistry.2023; : 1.     CrossRef
  • Multiplexed measurements of salivary fetuin-A, insulin, and adiponectin as potential non-invasive biomarkers in childhood obesity
    Vaithinathan Selvaraju, Jeganathan R. Babu, Thangiah Geetha
    Cytokine.2022; 153: 155843.     CrossRef
  • Recent Developments in Biomarkers for Diagnosis and Screening of Type 2 Diabetes Mellitus
    Margarita Ortiz-Martínez, Mirna González-González, Alexandro J. Martagón, Victoria Hlavinka, Richard C. Willson, Marco Rito-Palomares
    Current Diabetes Reports.2022; 22(3): 95.     CrossRef
  • Serum Fetuin-A and Risk of Gestational Diabetes Mellitus: An Observational Study and Mendelian Randomization Analysis
    Ping Wu, Yi Wang, Yi Ye, Xue Yang, Qi Lu, Jiaying Yuan, Li Zha, Yan Liu, Xingyue Song, Shijiao Yan, Ying Wen, Xiaorong Qi, Chun-Xia Yang, Yixin Wang, Gang Liu, Chuanzhu Lv, Xiong-Fei Pan, An Pan
    The Journal of Clinical Endocrinology & Metabolism.2022; 107(9): e3841.     CrossRef
  • Hepatokines as a Molecular Transducer of Exercise
    Dae Yun Seo, Se Hwan Park, Jubert Marquez, Hyo-Bum Kwak, Tae Nyun Kim, Jun Hyun Bae, Jin-Ho Koh, Jin Han
    Journal of Clinical Medicine.2021; 10(3): 385.     CrossRef
  • Serum Fetuin-B Levels Are Elevated in Women with Metabolic Syndrome and Associated with Increased Oxidative Stress
    Shiyao Xue, Hongdong Han, Shunli Rui, Mengliu Yang, Yizhou Huang, Bin Zhan, Shan Geng, Hua Liu, Chen Chen, Gangyi Yang, Ling Li, Colin Murdoch
    Oxidative Medicine and Cellular Longevity.2021; 2021: 1.     CrossRef
  • CD44, a Predominant Protein in Methylglyoxal-Induced Secretome of Muscle Cells, is Elevated in Diabetic Plasma
    Shakuntala Bai, Arvindkumar H. Chaurasiya, Reema Banarjee, Prachi B. Walke, Faraz Rashid, Ambika G. Unnikrishnan, Mahesh J. Kulkarni
    ACS Omega.2020; 5(39): 25016.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal