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Lwin Aung  (Aung L) 1 Article
Obesity and Metabolic Syndrome
Metabolic Surgery for Type 2 Diabetes Mellitus: Experience from Asia
Wei-Jei Lee, Lwin Aung
Diabetes Metab J. 2016;40(6):433-443.   Published online December 2, 2016
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  • 15 Web of Science
  • 16 Crossref
AbstractAbstract PDFPubReader   

Type 2 diabetes mellitus (T2DM) is a current global health priority and Asia is the epicenter of this epidemic disease. Unlike in the west, where older population is most affected, the burden of diabetes in Asian countries is disproportionately high in young to middle-age adults. The incidence of diabetic nephropathy is alarmingly high in patients with early onset T2DM, especially in those with poor glycemic control. How to control this chronic and debilitating disease is currently a very important health issue in Asia. Bariatric surgery has proven successful in treating not just obesity but also T2DM in morbid obese patients (body mass index [BMI] >35 kg/m2). Gastrointestinal metabolic surgery recently has been proposed as a new treatment modality for obesity related T2DM for patients with BMI <35 kg/m2. Many studies from Asia reported promising results of metabolic surgery to treat obese patients with T2DM which is not well controlled. It has been demonstrated that changes in gastrointestinal hormone secretion after gastrointestinal surgery would favor an early improvement of T2DM in Asians. New procedures have also been designed and proposed specifically for the treatment of diabetes in Asia. This article examines clinical trial data and accepted algorithms with a view toward elucidating the application of metabolic surgery for the treatment of T2DM in the Asia. We propose a systematic approach to surgical treatment, addressing current evidences, patient selection, procedure of choice, and timing and guideline for new procedures.


Citations to this article as recorded by  
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  • Diabetes resolution after one anastomosis gastric bypass
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  • Laparoscopic sleeve gastrectomy combined with single-anastomosis duodenal-jejunal bypass in the treatment of type 2 diabetes mellitus of patients with body mass index higher than 27.5 kg/m2 but lower than 32.5 kg/m2
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  • Comparison of Great Curvature Plication with Duodenal-Jejunal Bypass (GCP-DJB) and Sleeve Gastrectomy (SG) on Metabolic Indices and Gut Hormones in Type 2 Diabetes Mellitus Rats
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  • Ethnicity Does Not Influence Glycemic Outcomes or Diabetes Remission After Sleeve Gastrectomy or Gastric Bypass in a Multiethnic Asian Cohort
    Phong Ching Lee, Kwang Wei Tham, Sonali Ganguly, Hong Chang Tan, Alvin Kim Hock Eng, John B. Dixon
    Obesity Surgery.2018; 28(6): 1511.     CrossRef
  • Effects of GABAB receptor activation on spatial cognitive function and hippocampal neurones in rat models of type 2 diabetes mellitus
    Xiao-Jun Cai, Lei Wang, Chun-Mei Hu
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  • Metabolic surgery ameliorates cardiovascular risk in obese diabetic patients: Influence of different surgical procedures
    Jih-Hua Wei, Ruey-Hsing Chou, Po-Hsun Huang, Wei-Jei Lee, Shu-Chun Chen, Shing-Jong Lin
    Surgery for Obesity and Related Diseases.2018; 14(12): 1832.     CrossRef
  • Pulmonary function evaluation in type 2 diabetes mellitus patients submitted to metabolic surgery
    Ariana de Melo Tosta, Marisa de Carvalho Borges, Élida Mara Carneiro da Silva, Tharsus Dias Takeuti, Júverson Alves Terra Júnior, Eduardo Crema
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Diabetes Metab J : Diabetes & Metabolism Journal