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Kyung Taek Park  (Park KT) 1 Article
Effect of Granulocyte Colony-Stimulating Factor on the Peripheral Nerves in Streptozotocin-Induced Diabetic Rat
Kyung Ae Lee, Kyung Taek Park, Hea Min Yu, Heung Yong Jin, Hong Sun Baek, Tae Sun Park
Diabetes Metab J. 2013;37(4):286-290.   Published online August 14, 2013
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AbstractAbstract PDFPubReader   

There are controversial reports about the effect of granulocyte colony-stimulating factor (G-CSF) in peripheral nerve protection. Therefore, the present study aimed to investigate the effect of G-CSF on peripheral nerves in streptozotocin (STZ) induced diabetic rats. After STZ or vehicle injection, rats were divided into five groups (n=6) as follows: normal+vehicle, normal+G-CSF (50 µg/kg for 5 days), diabetes mellitus (DM)+vehicle, DM+G-CSF (50 µg/kg for 5 days), and DM+G-CSF extension (50 µg/kg for 5 days and followed by two injections per week up to 24 weeks). Our results showed that the current perception threshold was not significantly different among experimental groups. G-CSF treatment inhibited the loss of cutaneous nerves and gastric mucosal small nerve fibers in morphometric comparison, but statistical significance was not observed. The present results demonstrated that G-CSF has no harmful but minimal beneficial effects with respect to peripheral nerve preservation in diabetic rats.


Citations to this article as recorded by  
  • Colony stimulating factors in the nervous system
    Violeta Chitu, Fabrizio Biundo, E. Richard Stanley
    Seminars in Immunology.2021; 54: 101511.     CrossRef
  • Non-glucose risk factors in the pathogenesis of diabetic peripheral neuropathy
    Kyung Ae Lee, Tae Sun Park, Heung Yong Jin
    Endocrine.2020; 70(3): 465.     CrossRef
  • Two to Tango: Dialogue between Adaptive and Innate Immunity in Type 1 Diabetes
    Lin Sun, Shugang Xi, Guangyu He, Zhuo Li, Xiaokun Gang, Chenglin Sun, Weiying Guo, Guixia Wang
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  • Transplantation of human mobilized mononuclear cells improved diabetic neuropathy
    Se Hee Min, Jung Hee Kim, Yu Mi Kang, Seung Hak Lee, Byung-Mo Oh, Kyou-Sup Han, Meihua Zhang, Hoe Suk Kim, Woo Kyung Moon, Hakmo Lee, Kyong Soo Park, Hye Seung Jung
    Journal of Endocrinology.2018; 239(3): 277.     CrossRef
  • Granulocyte-colony stimulating factor as a treatment for diabetic neuropathy in rat
    Kyung-Soo Kim, Yi-Sun Song, Jiyong Jin, Jun-Ho Joe, Byung-Im So, Jun-Young Park, Cheng-Hu Fang, Mi Jung Kim, Youl-Hee Cho, Sejin Hwang, Young-Suck Ro, Hyuck Kim, You-Hern Ahn, Hak-Joon Sung, Jung-Joon Sung, Sung-Hye Park, Stuart A. Lipton
    Molecular and Cellular Endocrinology.2015; 414: 64.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal