- Clinical Diabetes & Therapeutics
- Effects of Lobeglitazone, a Novel Thiazolidinedione, on Bone Mineral Density in Patients with Type 2 Diabetes Mellitus over 52 Weeks
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Soo Lim, Kyoung Min Kim, Sin Gon Kim, Doo Man Kim, Jeong-Taek Woo, Choon Hee Chung, Kyung Soo Ko, Jeong Hyun Park, Yongsoo Park, Sang Jin Kim, Hak Chul Jang, Dong Seop Choi
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Diabetes Metab J. 2017;41(5):377-385. Published online October 24, 2017
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DOI: https://doi.org/10.4093/dmj.2017.41.5.377
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- Background
The aim of this multicenter, randomized, double-blind study was to examine the effect of lobeglitazone, a novel thiazolidinedione, on the changes in bone mineral density (BMD) in patients with type 2 diabetes mellitus. MethodsA 24-week, double-blinded phase was followed by a 28-week, open-label phase, in which the placebo group also started to receive lobeglitazone. A total of 170 patients aged 34 to 76 years were randomly assigned in a 2:1 ratio to receive lobeglitazone 0.5 mg or a matching placebo orally, once daily. BMD was assessed using dual-energy X-ray absorptiometry at week 24 and at the end of the study (week 52). ResultsDuring the double-blinded phase, the femur neck BMD showed decreasing patterns in both groups, without statistical significance (−0.85%±0.36% and −0.78%±0.46% in the lobeglitazone and placebo groups, respectively). The treatment difference between the groups was 0.07%, which was also not statistically significant. Further, minimal, nonsignificant decreases were observed in both groups in the total hip BMD compared to values at baseline, and these differences also did not significantly differ between the groups. During the open-label phase, the BMD was further decreased, but not significantly, by −0.32% at the femur neck and by −0.60% at the total hip in the lobeglitazone group, and these changes did not significantly differ compared with the original placebo group switched to lobeglitazone. ConclusionOur results indicate that treatment with lobeglitazone 0.5 mg over 52 weeks showed no detrimental effect on the BMD compared to the placebo.
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Laraib Javed, Aemen Khakwani, Uzair Khan, Mary Beth Humphrey The American Journal of the Medical Sciences.2024;[Epub] CrossRef - Efficacy and safety of novel thiazolidinedione lobeglitazone for managing type-2 diabetes a meta-analysis
Deep Dutta, Saptarshi Bhattacharya, Manoj Kumar, Priyankar K. Datta, Ritin Mohindra, Meha Sharma Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2023; 17(1): 102697. CrossRef - Efficacy and safety of lobeglitazone, a new Thiazolidinedione, as compared to the standard of care in type 2 diabetes mellitus: A systematic review and meta-analysis
Shashank R. Joshi, Saibal Das, Suja Xaviar, Shambo Samrat Samajdar, Indranil Saha, Sougata Sarkar, Shatavisa Mukherjee, Santanu Kumar Tripathi, Jyotirmoy Pal, Nandini Chatterjee Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2023; 17(1): 102703. CrossRef - The benefits of adipocyte metabolism in bone health and regeneration
Lisa-Marie Burkhardt, Christian H. Bucher, Julia Löffler, Charlotte Rinne, Georg N. Duda, Sven Geissler, Tim J. Schulz, Katharina Schmidt-Bleek Frontiers in Cell and Developmental Biology.2023;[Epub] CrossRef - Will lobeglitazone rival pioglitazone? A systematic review and critical appraisal
Kalyan Kumar Gangopadhyay, Awadhesh Kumar Singh Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2023; 17(4): 102747. CrossRef - Comparison of therapeutic efficacy and safety of sitagliptin, dapagliflozin, or lobeglitazone adjunct therapy in patients with type 2 diabetes mellitus inadequately controlled on sulfonylurea and metformin: Third agent study
Jun Hwa Hong, Jun Sung Moon, Kayeon Seong, Soo Lim Diabetes Research and Clinical Practice.2023; 203: 110872. CrossRef - Bone Mineral Density Evaluation Among Type 2 Diabetic Patients in Rural Haryana, India: An Analytical Cross-Sectional Study
Nitish Khandelwal, Surbhi Rajauria, Siddhesh Pandurang Kanjalkar, Omkar Shivaji Chavanke, Sanjay Rai Cureus.2023;[Epub] CrossRef - Lobeglitazone and Its Therapeutic Benefits: A Review
Balamurugan M, Sarumathy S, Robinson R Cureus.2023;[Epub] CrossRef - A double‐blind, Randomized controlled trial on glucose‐lowering EFfects and safety of adding 0.25 or 0.5 mg lobeglitazone in type 2 diabetes patients with INadequate control on metformin and dipeptidyl peptidase‐4 inhibitor therapy: REFIND study
Soree Ryang, Sang Soo Kim, Ji Cheol Bae, Ji Min Han, Su Kyoung Kwon, Young Il Kim, Il Seong Nam‐Goong, Eun Sook Kim, Mi‐kyung Kim, Chang Won Lee, Soyeon Yoo, Gwanpyo Koh, Min Jeong Kwon, Jeong Hyun Park, In Joo Kim Diabetes, Obesity and Metabolism.2022; 24(9): 1800. CrossRef - A Real-World Study of Long-Term Safety and Efficacy of Lobeglitazone in Korean Patients with Type 2 Diabetes Mellitus
Bo-Yeon Kim, Hyuk-Sang Kwon, Suk Kyeong Kim, Jung-Hyun Noh, Cheol-Young Park, Hyeong-Kyu Park, Kee-Ho Song, Jong Chul Won, Jae Myung Yu, Mi Young Lee, Jae Hyuk Lee, Soo Lim, Sung Wan Chun, In-Kyung Jeong, Choon Hee Chung, Seung Jin Han, Hee-Seok Kim, Ju-Y Diabetes & Metabolism Journal.2022; 46(6): 855. CrossRef - Comparative Efficacy of Lobeglitazone Versus Pioglitazone on Albuminuria in Patients with Type 2 Diabetes Mellitus
Kyung-Soo Kim, Sangmo Hong, Hong-Yup Ahn, Cheol-Young Park Diabetes Therapy.2021; 12(1): 171. CrossRef - Lobeglitazone: A Novel Thiazolidinedione for the Management of Type 2 Diabetes Mellitus
Jaehyun Bae, Taegyun Park, Hyeyoung Kim, Minyoung Lee, Bong-Soo Cha Diabetes & Metabolism Journal.2021; 45(3): 326. CrossRef - Effect of lobeglitazone on motor function in rat model of Parkinson’s disease with diabetes co-morbidity
Kambiz Hassanzadeh, Arman Rahimmi, Mohammad Raman Moloudi, Rita Maccarone, Massimo Corbo, Esmael Izadpanah, Marco Feligioni Brain Research Bulletin.2021; 173: 184. CrossRef - Recent Perspective on Thiazolidinedione
Won Jun Kim The Journal of Korean Diabetes.2021; 22(2): 97. CrossRef - Use of in vitro bone models to screen for altered bone metabolism, osteopathies, and fracture healing: challenges of complex models
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Khemayanto Hidayat, Xuan Du, Meng‐Jiao Wu, Bi‐Min Shi Obesity Reviews.2019; 20(10): 1494. CrossRef - Diabetes pharmacotherapy and effects on the musculoskeletal system
Evangelia Kalaitzoglou, John L. Fowlkes, Iuliana Popescu, Kathryn M. Thrailkill Diabetes/Metabolism Research and Reviews.2019;[Epub] CrossRef - Morin Exerts Anti‐Arthritic Effects by Attenuating Synovial Angiogenesis via Activation of Peroxisome Proliferator Activated Receptor‐γ
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- Clinical Care/Education
- Clinical Evaluation of OneTouch Diabetes Management Software System in Patients with Type 2 Diabetes Mellitus
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Jung Min Kim, Hey Jean Lee, Keum Ok Kim, Jong Chul Won, Kyung Soo Ko, Byung Doo Rhee
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Diabetes Metab J. 2016;40(2):129-139. Published online April 5, 2016
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DOI: https://doi.org/10.4093/dmj.2016.40.2.129
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- Background
OneTouch Diabetes Management Software (OTDMS) is an efficient way to track and monitor the blood glucose level. It is possible to download data from the OneTouch Ultra via the meter's data port, and to transform the numbers of the blood glucose level into a graph, a chart, or statistics. The objectives of this study were to evaluate whether the use of OTDMS in consultation hours would improve patients' knowledge of diabetes mellitus (DM), compliance, satisfaction with doctor and medical treatment, doctor-patient reliability, and glucose control. MethodsAll patients were randomized into either the OTDMS group using OneTouch Ultra or the control groups not using it. Both groups had conventional DM education and only the OTDMS group used data from OTDMS as explanation materials during consultation hours. At enrollment and after 6 months, we performed a questionnaire survey consisting of the diabetes knowledge test, items for compliance of treatment, patient's satisfaction, doctor-patient reliability, and glycosylated hemoglobin (HbA1c). ResultsWe analyzed 6-month follow-up data from 92 patients (OTDMS 42 vs. control 50). Both groups showed significant improvements in HbA1c, diabetes knowledge, compliance, reliability, and satisfaction after 6 months. However, there were no significant differences between OTDMS and control groups overall. Only "weekly frequency of checking blood glucose level" of compliance and "trying to follow doctor's order" of reliability showed better results in the OTDMS group. ConclusionUsing the OTDMS system for explanation during consultation hours seems to be more helpful to improve patient's compliance and reliability, especially for checking blood glucose level and trying to follow the doctor's order.
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Kristin J Konnyu, Sharlini Yogasingam, Johanie Lépine, Katrina Sullivan, Mostafa Alabousi, Alun Edwards, Michael Hillmer, Sathya Karunananthan, John N Lavis, Stefanie Linklater, Braden J Manns, David Moher, Sameh Mortazhejri, Samir Nazarali, P. Alison Pap Cochrane Database of Systematic Reviews.2023;[Epub] CrossRef - Emerging technologies for the management of type 2 diabetes mellitus
Nirali A. Shah, Carol J. Levy Journal of Diabetes.2021; 13(9): 713. CrossRef - Peripartum Management of Gestational Diabetes Using a Digital Health Care Service: A Pilot, Randomized Controlled Study
Ji-Hee Sung, Da Young Lee, Kyoung Pil Min, Cheol-Young Park Clinical Therapeutics.2019; 41(11): 2426. CrossRef - Impact of initial active engagement in self-monitoring with a telemonitoring device on glycemic control among patients with type 2 diabetes
Min-Kyung Lee, Kwang-Hyeon Lee, Seung-Hyun Yoo, Cheol-Young Park Scientific Reports.2017;[Epub] CrossRef - Potential of OneTouch Diabetes Management Software System in Real Field for Korean Type 2 Diabetes Patients
Borami Kang, Jae Hyoung Cho Diabetes & Metabolism Journal.2016; 40(2): 115. CrossRef
- Epidemiology
- Data Analytic Process of a Nationwide Population-Based Study Using National Health Information Database Established by National Health Insurance Service
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Yong-ho Lee, Kyungdo Han, Seung-Hyun Ko, Kyung Soo Ko, Ki-Up Lee
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Diabetes Metab J. 2016;40(1):79-82. Published online February 19, 2016
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DOI: https://doi.org/10.4093/dmj.2016.40.1.79
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In 2014, the National Health Insurance Service (NHIS) signed a memorandum of understanding with the Korean Diabetes Association to provide limited open access to its databases for investigating the past and current status of diabetes and its management. NHIS databases include the entire Korean population; therefore, it can be used as a population-based nationwide study for various diseases, including diabetes and its complications. This report presents how we established the analytic system of nation-wide population-based studies using the NHIS database as follows: the selection of database study population and its distribution and operational definition of diabetes and patients of currently ongoing collaboration projects.
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Jung Eun Yoo, Youn Huh, Sang-Hyun Park, Kyungdo Han, Hye Soon Park, Kyung Hwan Cho, Jin-Soo Ahn, Sang Ho Jun, Ga Eun Nam Journal of the American Medical Directors Association.2023; 24(12): 1924. CrossRef - The Effect of Cataract Surgery on the Risk of Dementia: A Nationwide Cohort Study
Chaeyeon Lee, Eunhae Shin, Mina Kim, Yoonjong Bae, Tae-Young Chung, Sang Won Seo, Hyemin Jang, Dong Hui Lim Journal of Clinical Medicine.2023; 12(20): 6441. CrossRef - The Impact of Neighborhood Deprivation on the Survival Rates of Patients with Cancer in Korea
Wonyoung Jung, Dong Wook Shin, Kyu-Won Jung, Dongjin Kim, Juwon Park, Fatima Nari, Mina Suh Healthcare.2023; 11(24): 3171. CrossRef - Declined incidence of patients treated for vision-threatening diabetic retinopathy in South Korea: a 12-year nationwide population-based study
Jiwon Kim, Hyojin Seong, Kang Ju Son, Eun Jee Chung Graefe's Archive for Clinical and Experimental Ophthalmology.2022; 260(1): 101. CrossRef - Female reproductive factors and risk of joint replacement arthroplasty of the knee and hip due to osteoarthritis in postmenopausal women: a nationwide cohort study of 1.13 million women
Y. Eun, J.E. Yoo, K. Han, D. Kim, K.N. Lee, J. Lee, D.-Y. Lee, D.-H. Lee, H. Kim, D.W. Shin Osteoarthritis and Cartilage.2022; 30(1): 69. CrossRef - Blood Pressure Levels and Risks of Dementia: a Nationwide Study of 4.5 Million People
Chan Joo Lee, Ji-Yeon Lee, Kyungdo Han, Da Hye Kim, Hanna Cho, Kwang Joon Kim, Eun Seok Kang, Bong-Soo Cha, Yong-ho Lee, Sungha Park Hypertension.2022; 79(1): 218. CrossRef - Changes in Metabolic Syndrome Status are Associated With Altered Risk of Pancreatic Cancer: A Nationwide Cohort Study
Joo-Hyun Park, Kyungdo Han, Jung Yong Hong, Young Suk Park, Kyu Yeon Hur, Gunseog Kang, Joon Oh Park Gastroenterology.2022; 162(2): 509. CrossRef - Acromegaly and cardiovascular outcomes: a cohort study
Sangmo Hong, Kyung-Soo Kim, Kyungdo Han, Cheol-Young Park European Heart Journal.2022; 43(15): 1491. CrossRef - Blood Pressure Variability and the Risk of Fracture: A Nationwide Cohort Study
Jung Eun Yoo, Ji Won Yoon, Hyo Eun Park, Kyungdo Han, Dong Wook Shin The Journal of Clinical Endocrinology & Metabolism.2022; 107(4): e1488. CrossRef - Cost-effectiveness analysis of intensive blood pressure control in Korea
Ye Seol Lee, Hae-Young Lee, Tae Hyun Kim Hypertension Research.2022; 45(3): 507. CrossRef - Associations of variability in body weight and glucose levels with the risk of hip fracture in people with diabetes
Jeongmin Lee, Kyungdo Han, Sang Hyun Park, Mee Kyoung Kim, Dong-Jun Lim, Kun-Ho Yoon, Moo-Il Kang, Seung-Hwan Lee Metabolism.2022; 129: 155135. CrossRef - Severe Hypoglycemia Increases Dementia Risk and Related Mortality: A Nationwide, Population-based Cohort Study
Eugene Han, Kyung-do Han, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Seung-Hyun Ko, Yong-ho Lee The Journal of Clinical Endocrinology & Metabolism.2022; 107(5): e1976. CrossRef - Association between alcohol consumption and pancreatic cancer risk differs by glycaemic status: A nationwide cohort study
Joo-Hyun Park, Kyungdo Han, Jung Yong Hong, Young Suk Park, Joon Oh Park European Journal of Cancer.2022; 163: 119. CrossRef - The risk of dementia in adults with abdominal aortic aneurysm
Hyung-jin Cho, Ju-hwan Yoo, Mi-hyeong Kim, Kyung-jai Ko, Kang-woong Jun, Kyung-do Han, Jeong-kye Hwang Scientific Reports.2022;[Epub] CrossRef - Female Reproductive Factors and the Risk of Bronchiectasis: A Nationwide Population-Based Longitudinal Study
Bumhee Yang, Dong-Hwa Lee, Kyungdo Han, Hayoung Choi, Hyung Koo Kang, Dong Wook Shin, Hyun Lee Biomedicines.2022; 10(2): 303. CrossRef - Incidence of Depression after Traumatic Brain Injury: A Nationwide Longitudinal Study of 2.2 Million Adults
Yoonjeong Choi, Eun Young Kim, Jiyu Sun, Han-Kyoul Kim, Ye Seol Lee, Byung-Mo Oh, Hye Yoon Park, Ja-Ho Leigh Journal of Neurotrauma.2022; 39(5-6): 390. CrossRef - Blood pressure and mortality after percutaneous coronary intervention: a population-based cohort study
Chung-woo Lee, Joo Kyung Lee, Yeon Joo Choi, Hyunjin Kim, Kyungdo Han, Jin-hyung Jung, Do Hoon Kim, Joo-Hyun Park Scientific Reports.2022;[Epub] CrossRef - Impaired Lung Function and Lung Cancer Incidence: A Nationwide Population-Based Cohort Study
Hye Seon Kang, Yong-Moon Park, Seung-Hyun Ko, Seung Hoon Kim, Shin Young Kim, Chi Hong Kim, Kyungdo Han, Sung Kyoung Kim Journal of Clinical Medicine.2022; 11(4): 1077. CrossRef - Analysis of Severe Hypoglycemia Among Adults With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease
Ji-Yeon Lee, Young-eun Kim, Kyungdo Han, Eugene Han, Byung Wan Lee, Eun Seok Kang, Bong-Soo Cha, Seung-Hyun Ko, Yong-ho Lee JAMA Network Open.2022; 5(2): e220262. CrossRef - Smoking, Alcohol Consumption, and the Risk of Thyroid Cancer: A Population-Based Korean Cohort Study of 10 Million People
Yohwan Yeo, Dong Wook Shin, Kyungdo Han, Dahye Kim, Tae Hyuk Kim, Sohyun Chun, Su-Min Jeong, Yun-Mi Song Thyroid.2022; 32(4): 440. CrossRef - The Influence of Obesity and Metabolic Health on Vascular Health
Eun-Jung Rhee Endocrinology and Metabolism.2022; 37(1): 1. CrossRef - Association between lung function and the risk of atrial fibrillation in a nationwide population cohort study
Su Nam Lee, Seung-Hyun Ko, Sung-Ho Her, Kyungdo Han, Donggyu Moon, Sung Kyoung Kim, Ki-Dong Yoo, Yu-Bae Ahn Scientific Reports.2022;[Epub] CrossRef - Hip Fracture Risk According to Diabetic Kidney Disease Phenotype in a Korean Population
Seung Eun Lee, Juhwan Yoo, Kyoung-Ah Kim, Kyungdo Han, Han Seok Choi Endocrinology and Metabolism.2022; 37(1): 148. CrossRef - Medical Utilization and Costs in Preterm Infants in the First 6 Years of Life After Discharge From Neonatal Intensive Care Unit: A Nationwide Population-Based Study in Korea
Ju Hyun Jin, Sang Ah Lee, Shin Won Yoon Journal of Korean Medical Science.2022;[Epub] CrossRef - Low waist circumference prior to percutaneous coronary intervention predict the risk for end-stage renal disease: a nationwide Korean population based-cohort study
Eun Hui Bae, Sang Yup Lim, Eun Mi Yang, Tae Ryom Oh, Hong Sang Choi, Chang Seong Kim, Seong Kwon Ma, Bongseong Kim, Kyung-Do Han, Soo Wan Kim The Korean Journal of Internal Medicine.2022; 37(3): 639. CrossRef - Comparative analysis of cardio-cerebrovascular complications in immigrants and native-born Koreans with diabetes: Risk factors and perspectives
Hyemin Cho, Sohyun Jeoung, Cinoo Kang, Sunmee Jang, Chaisiri Angkurawaranon PLOS ONE.2022; 17(4): e0263046. CrossRef - Changes in Physical Activity and the Risk of Dementia in Patients With New-Onset Type 2 Diabetes: A Nationwide Cohort Study
Jung Eun Yoo, Kyungdo Han, Bongseong Kim, Sang-Hyun Park, Seon Mee Kim, Hye Soon Park, Ga Eun Nam Diabetes Care.2022; 45(5): 1091. CrossRef - Understanding and Utilizing Claim Data from the Korean National Health Insurance Service (NHIS) and Health Insurance Review & Assessment (HIRA) Database for Research
Dae-Sung Kyoung, Hun-Sung Kim Journal of Lipid and Atherosclerosis.2022; 11(2): 103. CrossRef - Annual Trends in the Incidence and Prevalence of Alzheimer's Disease in South Korea: A Nationwide Cohort Study
Min Seok Baek, Han-Kyeol Kim, Kyungdo Han, Hyuk-Sung Kwon, Han Kyu Na, Chul Hyoung Lyoo, Hanna Cho Frontiers in Neurology.2022;[Epub] CrossRef - Combined Effects of Chronic Kidney Disease and Nonalcoholic Fatty Liver Disease on the Risk of Cardiovascular Disease in Patients with Diabetes
Goh-Eun Chung, Kyungdo Han, Kyu-Na Lee, Eun-Ju Cho, Jung-Ho Bae, Sun-Young Yang, Su-Jong Yu, Seung-Ho Choi, Jeong-Yoon Yim, Nam-Ju Heo Biomedicines.2022; 10(6): 1245. CrossRef - Light-to-Moderate Alcohol Consumption Increases the Risk of Biliary Tract Cancer in Prediabetes and Diabetes, but Not in Normoglycemic Status: A Nationwide Cohort Study
Joo-Hyun Park, Jung Yong Hong, Kyungdo Han, Young Suk Park, Joon Oh Park Journal of Clinical Oncology.2022; 40(31): 3623. CrossRef - Nationwide population-based incidence of cancer among patients with HIV/AIDS in South Korea
Soon Ok Lee, Jeong Eun Lee, Shinwon Lee, Sun Hee Lee, Jin Suk Kang, Hyunjin Son, Hyungi Lee, Jinmi Kim Scientific Reports.2022;[Epub] CrossRef - Increased risk of pancreatic cancer in individuals with non-alcoholic fatty liver disease
Joo-Hyun Park, Jung Yong Hong, Kyungdo Han, Wonseok Kang, Joo Kyung Park Scientific Reports.2022;[Epub] CrossRef - Colonoscopy decreases mortality in colorectal cancer patients compared with fecal immunochemical test
Soo‐Yoon Sung, Hyun Ho Choi, Sukil Kim, Bo Ram Park, Young Ki Kim, Hyung‐Keun Kim, Young‐Seok Cho, Sang Woo Kim, Sung Soo Kim, Hiun‐Suk Chae Journal of Gastroenterology and Hepatology.2022; 37(10): 1991. CrossRef - Factors Affecting the Occurrence of Mental Health Problems in Female Cancer Survivors: A Nationwide Cohort Study
So Young Kim, Yeonju Lee, Sang Baek Koh International Journal of Environmental Research and Public Health.2022; 19(14): 8615. CrossRef - Risk for Behçet’s disease gauged via high-density lipoprotein cholesterol: a nationwide population-based study in Korea
Yeong Ho Kim, Hyun Jee Kim, Jin Woo Park, Kyung Do Han, Yong Gyu Park, Young Bok Lee, Ji Hyun Lee Scientific Reports.2022;[Epub] CrossRef - Comparative Effects of Sodium-Glucose Cotransporter 2 Inhibitor and Thiazolidinedione Treatment on Risk of Stroke among Patients with Type 2 Diabetes Mellitus
Seung Eun Lee, Hyewon Nam, Han Seok Choi, Hoseob Kim, Dae-Sung Kyoung, Kyoung-Ah Kim Diabetes & Metabolism Journal.2022; 46(4): 567. CrossRef - Current Trends of Big Data Research Using the Korean National Health Information Database
Mee Kyoung Kim, Kyungdo Han, Seung-Hwan Lee Diabetes & Metabolism Journal.2022; 46(4): 552. CrossRef - Recent Increases in Influenza-Related Hospitalizations, Critical Care Resource Use, and In-Hospital Mortality: A 10-Year Population-Based Study in South Korea
Tae Hwa Hong, Hyung Seok Lee, Nam-Eun Kim, Kyu Jin Lee, Yong Kyun Kim, Jung Nam An, Joo-Hee Kim, Hyung Won Kim, Sunghoon Park Journal of Clinical Medicine.2022; 11(16): 4911. CrossRef - Myocardial Infarction, Stroke, and All-Cause Mortality according to Low-Density Lipoprotein Cholesterol Level in the Elderly, a Nationwide Study
You-Bin Lee, Minji Koo, Eunjin Noh, Soon Young Hwang, Jung A Kim, Eun Roh, So-hyeon Hong, Kyung Mook Choi, Sei Hyun Baik, Geum Joon Cho, Hye Jin Yoo Diabetes & Metabolism Journal.2022; 46(5): 722. CrossRef - Severe hypoglycemia and risk of hospitalization for heart failure in adults with diabetes treated with oral medications with or without insulin: A population-based study
You-Bin Lee, Yoon-Jong Bae, Hoseob Kim, Jiyun Park, So Yoon Kwon, So Hee Park, Gyuri Kim, Kyu Yeon Hur, Jae Hyeon Kim, Sang-Man Jin Diabetes Research and Clinical Practice.2022; 192: 110083. CrossRef - Real-World Prescription Patterns and Barriers Related to the Use of Sodium-Glucose Cotransporter 2 Inhibitors among Korean Patients with Type 2 Diabetes Mellitus and Cardiovascular Disease
Jong Ha Baek, Ye Seul Yang, Seung-Hyun Ko, Kyung Do Han, Jae Hyeon Kim, Min Kyong Moon, Jong Suk Park, Byung-Wan Lee, Tae Jung Oh, Suk Chon, Jong Han Choi, Kyu Yeon Hur Diabetes & Metabolism Journal.2022; 46(5): 701. CrossRef - Association between Age-Related Macular Degeneration and the Risk of Diabetes Mellitus: A Nationwide Cohort Study
Wonyoung Jung, Je Moon Yoon, Kyungdo Han, Bongseong Kim, Sungsoon Hwang, Dong Hui Lim, Dong Wook Shin Biomedicines.2022; 10(10): 2435. CrossRef - Development and Evaluation of Machine Learning-Based High-Cost Prediction Model Using Health Check-Up Data by the National Health Insurance Service of Korea
Yeongah Choi, Jiho An, Seiyoung Ryu, Jaekyeong Kim International Journal of Environmental Research and Public Health.2022; 19(20): 13672. CrossRef - The presence of hypertension during pregnancy determines the future risk of metabolic syndrome: An observational study
Da-Hye Ju, Hyeyoun Lee, Sang Jin Ha Medicine.2022; 101(42): e31272. CrossRef - Association of height loss and cardiovascular disease: Data from a large Korean cohort
Jeonggeun Moon, Pyung Chun Oh, Kyounghoon Lee, Ho-Jun Jang, Tae-Hoon Kim, Sang-Don Park, Sung Woo Kwon, Min Gyu Kong, Jon Suh, Woong Chol Kang Frontiers in Cardiovascular Medicine.2022;[Epub] CrossRef - Association between serum ferritin levels and colorectal cancer risk in Korea
Hyunho Kim, Kyungdo Han, Seung-Hyun Ko, Ho Jung An The Korean Journal of Internal Medicine.2022; 37(6): 1205. CrossRef - Fasting Glucose Variability and the Risk of Dementia in Individuals with Diabetes: A Nationwide Cohort Study
Da Young Lee, Jaeyoung Kim, Sanghyun Park, So Young Park, Ji Hee Yu, Ji A Seo, Nam Hoon Kim, Hye Jin Yoo, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Kyungdo Han, Nan Hee Kim Diabetes & Metabolism Journal.2022; 46(6): 923. CrossRef - Associations between migraine and major cardiovascular events in type 2 diabetes mellitus
Dae Young Cheon, Kyungdo Han, Ye Seul Yang, Yerim Kim, Sang-Hwa Lee, Chulho Kim, Jong-Hee Sohn, Mi Sun Oh, Byung-Chul Lee, Minwoo Lee, Kyung-Ho Yu Cardiovascular Diabetology.2022;[Epub] CrossRef - The Dose-Response Association between Smoking and the Risk of Gallbladder Cancer Differs by Glycemic Status: A Nationwide Cohort Study
Joo-Hyun Park, Jung Yong Hong, Kyungdo Han SSRN Electronic Journal .2022;[Epub] CrossRef - Threshold Dose-Response Association between Smoking Pack-Years and the Risk of Gallbladder Cancer: A Nationwide Cohort Study
Joo-Hyun Park, Jung Yong Hong, Kyungdo Han SSRN Electronic Journal .2022;[Epub] CrossRef - Cardiovascular and renal effectiveness of empagliflozin in routine care in East Asia: Results from the EMPRISE East Asia study
Yutaka Seino, Dae Jung Kim, Daisuke Yabe, Elise Chia‐Hui Tan, Wook‐Jin Chung, Kyoung Hwa Ha, Masaomi Nangaku, Koichi Node, Riho Klement, Atsutaka Yasui, Wei‐Yu Lei, Sunwoo Lee, Moe H. Kyaw, Anouk Deruaz‐Luyet, Kimberly G. Brodovicz, Wayne H.‐H. Sheu Endocrinology, Diabetes & Metabolism.2021;[Epub] CrossRef - Tooth loss and risk of end‐stage renal disease: A nationwide cohort study
Kyungdo Han, Jun‐Beom Park Journal of Periodontology.2021; 92(3): 371. CrossRef - Both cardiovascular and cerebrovascular events are decreased following long‐term narrowband ultraviolet B phototherapy in patients with vitiligo: a propensity score matching analysis
J.M. Bae, Y.‐S. Kim, E.H. Choo, M.‐Y. Kim, J.Y. Lee, H.‐O. Kim, Y.M. Park Journal of the European Academy of Dermatology and Venereology.2021; 35(1): 222. CrossRef - The risk of hip fractures in individuals over 50 years old with prediabetes and type 2 diabetes – A longitudinal nationwide population-based study
Ho Youn Park, Kyoungdo Han, Youngwoo Kim, Yoon Hwan Kim, Yoo Joon Sur Bone.2021; 142: 115691. CrossRef - Association of Female Reproductive Factors With Incidence of Fracture Among Postmenopausal Women in Korea
Jung Eun Yoo, Dong Wook Shin, Kyungdo Han, Dahye Kim, Ji Won Yoon, Dong-Yun Lee JAMA Network Open.2021; 4(1): e2030405. CrossRef - Status of Diabetic Neuropathy in Korea: A National Health Insurance Service-National Sample Cohort Analysis (2006 to 2015)
Seong-Su Moon, Chong Hwa Kim, Seon Mee Kang, Eun Sook Kim, Tae Jung Oh, Jae-Seung Yun, Ho Chan Cho, Dae Jung Kim, Tae Sun Park Diabetes & Metabolism Journal.2021; 45(1): 115. CrossRef - High-Density Lipoprotein Cholesterol and the Risk of Myocardial Infarction, Stroke, and Cause-Specific Mortality: a Nationwide Cohort Study in Korea
Yeoree Yang, Kyungdo Han, Sang Hyun Park, Mee Kyoung Kim, Kun-Ho Yoon, Seung-Hwan Lee Journal of Lipid and Atherosclerosis.2021; 10(1): 74. CrossRef - Estimated Incidence and Projections of Treatment Cost for Vision-threatening Diabetic Retinopathy in Korea
Hyo Jin Seong, Jiwon Kim, Sunok Song, Kangju Son, Sungyong Park, Eun Jee Chung Journal of the Korean Ophthalmological Society.2021; 62(1): 55. CrossRef - Risk of gastrointestinal cancer in patients with an elevated level of gamma-glutamyltransferase: A nationwide population-based study
Seung Wook Hong, Hyun Jung Lee, Kyungdo Han, Jung Min Moon, Seona Park, Hosim Soh, Eun Ae Kang, Jaeyoung Chun, Jong Pil Im, Joo Sung Kim, Wisit Cheungpasitporn PLOS ONE.2021; 16(2): e0245052. CrossRef - Descriptive epidemiology on the trends and sociodemographic risk factors of disease burden in years of life lost due to suicide in South Korea from 2000 to 2018
Keun A Kim, Young-Eun Kim, Seok-Jun Yoon BMJ Open.2021; 11(2): e043662. CrossRef - Obesity, Abdominal Obesity and Chronic Kidney Disease in Young Adults: A Nationwide Population-Based Cohort Study
Eun Hui Bae, Sang Yeob Lim, Jin-Hyung Jung, Tae Ryom Oh, Hong Sang Choi, Chang Seong Kim, Seong Kwon Ma, Kyung-Do Han, Soo Wan Kim Journal of Clinical Medicine.2021; 10(5): 1065. CrossRef - Association of particulate matter with autoimmune rheumatic diseases among adults in South Korea
Jun Seok Park, Seulggie Choi, Kyuwoong Kim, Jooyoung Chang, Sung Min Kim, Seong Rae Kim, Gyeongsil Lee, Joung Sik Son, Kyae Hyung Kim, Eun Young Lee, Sang Min Park Rheumatology.2021; 60(11): 5117. CrossRef - Chronic Kidney Disease Risk of Isolated Systolic or Diastolic Hypertension in Young Adults: A Nationwide Sample Based‐Cohort Study
Eun Hui Bae, Sang Yeob Lim, Jin‐Hyung Jung, Tae Ryom Oh, Hong Sang Choi, Chang Seong Kim, Seong Kwon Ma, Kyung‐Do Han, Soo Wan Kim Journal of the American Heart Association.2021;[Epub] CrossRef - Association between non-alcoholic fatty liver disease and the risk of biliary tract cancers: A South Korean nationwide cohort study
Joo-Hyun Park, Jung Yong Hong, Minsuk Kwon, Jiyun Lee, Kyungdo Han, In Woong Han, Wonseok Kang, Joo Kyung Park European Journal of Cancer.2021; 150: 73. CrossRef - Deep Spinal Infection after Outpatient Epidural Injections for Pain: A Retrospective Sample Cohort Study Using a Claims Database in South Korea
Chang-Soon Lee, Young Jae Park, Jee Youn Moon, Yong-Chul Kim Anesthesiology.2021; 134(6): 925. CrossRef - Obesity, metabolic health, and urological disorders in adults: a nationwide population-based study
Jong Keun Kim, Young Goo Lee, Kyungdo Han, Jun Hyun Han Scientific Reports.2021;[Epub] CrossRef - Risks and Prognoses of Alzheimer's Disease and Vascular Dementia in Patients With Insomnia: A Nationwide Population-Based Study
Min Seok Baek, Kyungdo Han, Hyuk-Sung Kwon, Yong-ho Lee, Hanna Cho, Chul Hyoung Lyoo Frontiers in Neurology.2021;[Epub] CrossRef - Cumulative Exposure to Metabolic Syndrome Components and the Risk of Dementia: A Nationwide Population-Based Study
Yunjung Cho, Kyungdo Han, Da Hye Kim, Yong-Moon Park, Kun-Ho Yoon, Mee Kyoung Kim, Seung-Hwan Lee Endocrinology and Metabolism.2021; 36(2): 424. CrossRef - Changes in Smoking, Alcohol Consumption, and the Risk of Thyroid Cancer: A Population-Based Korean Cohort Study
Yohwan Yeo, Kyungdo Han, Dong-Wook Shin, Dahye Kim, Su-Min Jeong, Sohyun Chun, In-Young Choi, Keun-Hye Jeon, Tae-Hyuk Kim Cancers.2021; 13(10): 2343. CrossRef - Association between obesity and the risk of gastric cancer in premenopausal and postmenopausal women: A nationwide cohort study
In Young Choi, Yoon Jin Choi, Dong Wook Shin, Kyung Do Han, Keun Hye Jeon, Su‐Min Jeong, Jung Eun Yoo Journal of Gastroenterology and Hepatology.2021; 36(10): 2834. CrossRef - Reproductive risk factors of pterygium in postmenopausal women: a nationwide study in the Republic of Korea
Eunhae Shin, Dong Hui Lim, Tae-Young Chung, Gyule Han, Jung Eun Yoo, Keun Hye Jeon, Kyungdo Han, Dong Wook Shin Scientific Reports.2021;[Epub] CrossRef - Association of mortality with drug-coated devices in femoropopliteal artery based on the nationwide data
Hyunsook Choi, Haine Lee, Sang-Soo Lee, Jeonghoon Ahn, Jin Hyun Joh, Moo-Yeol Lee Annals of Surgical Treatment and Research.2021; 101(1): 20. CrossRef - Trends and risk factors in severe hypoglycemia among individuals with type 2 diabetes in Korea
Seung Eun Lee, Kyoung-Ah Kim, Kang Ju Son, Sun Ok Song, Kyeong Hye Park, Se Hee Park, Joo Young Nam Diabetes Research and Clinical Practice.2021; 178: 108946. CrossRef - Association between Relative Preference for Vegetables and Meat and Cancer Incidence in Korean Adults: A Nationwide Population-based Retrospective Cohort Study
Ga-Eun Yie, An Na Kim, Hyun Jeong Cho, Minji Kang, Sungji Moon, Inah Kim, Kwang-Pil Ko, Jung Eun Lee, Sue K. Park Korean Journal of Community Nutrition.2021; 26(3): 211. CrossRef - Comparison of fracture risk between type 1 and type 2 diabetes: a comprehensive real-world data
J. Ha, C. Jeong, K.-D. Han, Y. Lim, M.K. Kim, H.-S. Kwon, K.-H. Song, M.I. Kang, K.-H. Baek Osteoporosis International.2021; 32(12): 2543. CrossRef - Dose-Dependent Effect of Smoking on Risk of Diabetes Remains after Smoking Cessation: A Nationwide Population-Based Cohort Study in Korea
Se Eun Park, Mi Hae Seo, Jung-Hwan Cho, Hyemi Kwon, Yang-Hyun Kim, Kyung-Do Han, Jin-Hyung Jung, Yong-Gyu Park, Eun-Jung Rhee, Won-Young Lee Diabetes & Metabolism Journal.2021; 45(4): 539. CrossRef - Development and Validation of a Deep Learning Based Diabetes Prediction System Using a Nationwide Population-Based Cohort
Sang Youl Rhee, Ji Min Sung, Sunhee Kim, In-Jeong Cho, Sang-Eun Lee, Hyuk-Jae Chang Diabetes & Metabolism Journal.2021; 45(4): 515. CrossRef - The beneficial effects of menopausal hormone therapy on renal survival in postmenopausal Korean women from a nationwide health survey
Shin Young Ahn, Yoon Jin Choi, Jieun Kim, Gang Jee Ko, Young Joo Kwon, Kyungdo Han Scientific Reports.2021;[Epub] CrossRef - Association of prediabetes, diabetes, and diabetes duration with biliary tract cancer risk: A nationwide cohort study
Joo-Hyun Park, Jung Yong Hong, Young Suk Park, Gunseog Kang, Kyungdo Han, Joon Oh Park Metabolism.2021; 123: 154848. CrossRef - Early mortality and cardiovascular disease, varied association with body mass index and its changes in insulin-treated diabetes: a nationwide study
You-Bin Lee, Bongsung Kim, Jiyun Park, Minyoung Kim, Min Sun Choi, Gyuri Kim, Sang-Man Jin, Kyu Yeon Hur, Kyungdo Han, Jae Hyeon Kim International Journal of Obesity.2021; 45(11): 2482. CrossRef - Patient-Level Cancer Prediction Models From a Nationwide Patient Cohort: Model Development and Validation
Eunsaem Lee, Se Young Jung, Hyung Ju Hwang, Jaewoo Jung JMIR Medical Informatics.2021; 9(8): e29807. CrossRef - Impact of COVID-19 on Heart Failure Patients in South Korea
Minkook Son, Yoon Sung Jo, Sangyong Jo, Kyungil Park International Heart Journal.2021; 62(5): 1083. CrossRef - Statin use for primary prevention in patients with type 2 diabetes: Can it benefit all ages? – A nationwide propensity-matched cohort study
Ji Eun Jun, In-Kyung Jeong, Kyu Jeung Ahn, Ho Yeon Chung, You-Cheol Hwang Diabetes Research and Clinical Practice.2021; 180: 109044. CrossRef - Blood pressure prior to percutaneous coronary intervention is associated with the risk of end-stage renal disease: a nationwide population based-cohort study
Eun Hui Bae, Sang Yup Lim, Bongseong Kim, Kyung-Do Han, Tae Ryom Oh, Hong Sang Choi, Chang Seong Kim, Seong Kwon Ma, Soo Wan Kim Kidney Research and Clinical Practice.2021; 40(3): 432. CrossRef - Combination of Statin and Ezetimibe versus Statin Monotherapy on Cardiovascular Disease and Type 2 Diabetes Incidence among Adults with Impaired Fasting Glucose: a Propensity-Matched Nationwide Cohort Study
You-Bin Lee, Bongsung Kim, Kyungdo Han, Jung A Kim, Eun Roh, So-hyeon Hong, Kyung Mook Choi, Sei Hyun Baik, Hye Jin Yoo Journal of Lipid and Atherosclerosis.2021; 10(3): 303. CrossRef - The association of hepatic steatosis and fibrosis with heart failure and mortality
Jiyun Park, Gyuri Kim, Hasung Kim, Jungkuk Lee, You-Bin Lee, Sang-Man Jin, Kyu Yeon Hur, Jae Hyeon Kim Cardiovascular Diabetology.2021;[Epub] CrossRef - Increased depression risk in patients with abdominal aortic aneurysm: a nationwide cohort study
Mi-hyeong Kim, Ju-hwan Yoo, Hyung-jin Cho, Kyung-Jai Ko, Kang-woong Jun, Kyung-do Han, Jeong-kye Hwang Annals of Surgical Treatment and Research.2021; 101(5): 291. CrossRef - Relationship between blood pressure levels and ischemic stroke, myocardial infarction, and mortality in very elderly patients taking antihypertensives: a nationwide population-based cohort study
Myung-Sun Song, Yeon joo Choi, Hyunjin Kim, Myung Ji Nam, Chung-woo Lee, Kyungdo Han, Jin-Hyung Jung, Yong-Gyu Park, Do-Hoon Kim, Joo-Hyun Park BMC Geriatrics.2021;[Epub] CrossRef - Risk of Diabetes in Subjects with Positive Fecal Immunochemical Test: A Nationwide Population-Based Study
Kwang Woo Kim, Hyun Jung Lee, Kyungdo Han, Jung Min Moon, Seung Wook Hong, Eun Ae Kang, Jooyoung Lee, Hosim Soh, Seong-Joon Koh, Jong Pil Im, Joo Sung Kim Endocrinology and Metabolism.2021; 36(5): 1069. CrossRef - The Impact of Abdominal Aortic Aneurysm on Cardiovascular Diseases
Kyung Jai Ko, Ju Hwan Yoo, Hyung Jin Cho, Mi Hyeong Kim, Kang Woong Jun, Kyung Do Han, Jeong Kye Hwang International Heart Journal.2021; 62(6): 1235. CrossRef - A Study on Metabolic Health Status as a Risk Factor for Female Bladder Cancer Incidence: Analysis From the National Health Checkups Database of Korea
Da Eun Han, Sun Tae Ahn, Jong Wook Kim, Mi Mi Oh, Du Geon Moon, Kyungdo Han, Hong Seok Park The Korean Journal of Urological Oncology.2021; 19(4): 223. CrossRef - Fasting Glucose Variability as a Risk Indicator for End-Stage Kidney Disease in Patients with Diabetes: A Nationwide Population-Based Study
Da Young Lee, Jaeyoung Kim, Sanghyun Park, So Young Park, Ji Hee Yu, Ji A. Seo, Nam Hoon Kim, Hye Jin Yoo, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Kyungdo Han, Nan Hee Kim Journal of Clinical Medicine.2021; 10(24): 5948. CrossRef - Female Reproductive Factors and Risk of Bronchiectasis: A Nationwide Population-Based Longitudinal Study
Bumhee Yang, Dong-Hwa Lee, Kyungdo Han, Hayoung Choi, Hyung Koo Kang, Dong Wook Shin, Hyun Lee SSRN Electronic Journal .2021;[Epub] CrossRef - Changes in Direct Healthcare Costs before and after the Diagnosis of Inflammatory Bowel Disease: A Nationwide Population-Based Study
Jooyoung Lee, Jong Pil Im, Kyungdo Han, Jihye Kim, Hyun Jung Lee, Jaeyoung Chun, Joo Sung Kim Gut and Liver.2020; 14(1): 89. CrossRef - Non‐melanoma skin cancer as a clinical marker for internal malignancies: a nationwide population‐based cohort study
S.J. Yun, J.M. Bae, H. Kim, B.C. Park, J.S. Kim, S.H. Seo, H.H. Ahn, D.Y. Lee, Y.C. Kim, H.J. Park, K.Y. Chung Journal of the European Academy of Dermatology and Venereology.2020; 34(4): 746. CrossRef - The prognoses and postoperative outcomes of patients with both colorectal cancer and liver cirrhosis based on a nationwide cohort in Korea
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Cheol Min Shin, Nayoung Kim, Kyungdo Han, Bongseong Kim, Jin Hyung Jung, Tae Jung Oh, Dong Ho Lee Cancer Epidemiology.2020; 64: 101658. CrossRef - Longitudinal Study of Diabetic Differences between International Migrants and Natives among the Asian Population
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Ji Hee Yu, Kyungdo Han, Sanghyun Park, Hanna Cho, Da Young Lee, Jin-Wook Kim, Ji A Seo, Sin Gon Kim, Sei Hyun Baik, Yong Gyu Park, Kyung Mook Choi, Seon Mee Kim, Nan Hee Kim Diabetes & Metabolism Journal.2020; 44(1): 113. CrossRef - Sex differences in smoking, alcohol consumption, and risk of Parkinson's disease: A nationwide cohort study
Ryul Kim, Dallah Yoo, Yu Jin Jung, Kyungdo Han, Jee-Young Lee Parkinsonism & Related Disorders.2020; 71: 60. CrossRef - Blood Pressure Variability and Incidence of New-Onset Atrial Fibrillation
So-Ryoung Lee, You-Jung Choi, Eue-Keun Choi, Kyung-Do Han, Euijae Lee, Myung-Jin Cha, Seil Oh, Gregory Y.H. Lip Hypertension.2020; 75(2): 309. CrossRef - Annual Prevalence, Health Expenditures, and Co-Morbidities Trend of Iron Deficiency Anemia in Korea: National Health Insurance Service Data from 2002 to 2013
Yoo-Jin Park, Hee-Sook Lim, Tae-Hee Kim International Journal of Environmental Research and Public Health.2020; 17(12): 4433. CrossRef - Changes in Metabolic Syndrome Status and Risk of Dementia
Ji Eun Lee, Dong Wook Shin, Kyungdo Han, Dahye Kim, Jung Eun Yoo, Jinkook Lee, SangYun Kim, Ki Young Son, Belong Cho, Moon Jong Kim Journal of Clinical Medicine.2020; 9(1): 122. CrossRef - Blood Pressure Variability and the Risk of Dementia
Jung Eun Yoo, Dong Wook Shin, Kyungdo Han, Dahye Kim, Seung-Pyo Lee, Su-Min Jeong, Jinkook Lee, SangYun Kim Hypertension.2020; 75(4): 982. CrossRef - Gliclazide monotherapy increases risks of all-cause mortality and has similar risk of acute myocardial infarction and stroke with glimepiride monotherapy in Korean type 2 diabetes mellitus
Eun-Hee Cho, Kyungdo Han, Bongseong Kim, Dae Ho Lee Medicine.2020; 99(29): e21236. CrossRef - Risk of Cardiovascular Disease and Chronic Kidney Disease According to 2017 Blood Pressure Categories in Diabetes Mellitus
Yong Tae Kim, Hyung Joon Chung, Bo Ram Park, Yeon Yong Kim, Jun Hyeok Lee, Dae Ryong Kang, Jang-Young Kim, Mi Young Lee, Jun Young Lee Hypertension.2020; 76(3): 766. CrossRef - The Burden of Cervical Cancer in Korea: A Population-Based Study
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Hyun Ju Kim, Yun Jin Kim, Seung In Seo, Woon Geon Shin, Chan Hyuk Park Gastrointestinal Endoscopy.2020; 92(3): 613. CrossRef - Site-specific cancer risk in patients with type 2 diabetes: a nationwide population-based cohort study in Korea
Suk Kyeong Kim, Ju-Young Jang, Dong-Lim Kim, Young A Rhyu, Suh Eun Lee, Seung-Hyun Ko, Kyungdo Han, Kee-Ho Song The Korean Journal of Internal Medicine.2020; 35(3): 641. CrossRef - Cardiovascular Research Using the Korean National Health Information Database
Eue-Keun Choi Korean Circulation Journal.2020; 50(9): 754. CrossRef - Gamma‐glutamyl transferase variability and risk of dementia: A nationwide study
You‐Bin Lee, Kyungdo Han, Sanghyun Park, Seon Mee Kim, Nan Hee Kim, Kyung Mook Choi, Sei Hyun Baik, Yong Gyu Park, Hye Jin Yoo International Journal of Geriatric Psychiatry.2020; 35(10): 1105. CrossRef - Gamma-glutamyl transferase variability can predict the development of end-stage of renal disease: a nationwide population-based study
Da Young Lee, Kyungdo Han, Ji Hee Yu, Sanghyun Park, Jee-In Heo, Ji A. Seo, Nam Hoon Kim, Hye Jin Yoo, Sin Gon Kim, Seon Mee Kim, Kyung Mook Choi, Sei Hyun Baik, Yong Gyu Park, Nan Hee Kim Scientific Reports.2020;[Epub] CrossRef - Hospitalization for heart failure incidence according to the transition in metabolic health and obesity status: a nationwide population-based study
You-Bin Lee, Da Hye Kim, Seon Mee Kim, Nan Hee Kim, Kyung Mook Choi, Sei Hyun Baik, Yong Gyu Park, Kyungdo Han, Hye Jin Yoo Cardiovascular Diabetology.2020;[Epub] CrossRef - Statins and metachronous recurrence after endoscopic resection of early gastric cancer: a nationwide Korean cohort study
Hyunsoo Chung, Hyun Ju Kim, Hyun Chae Jung, Sang Kil Lee, Sang Gyun Kim Gastric Cancer.2020; 23(4): 659. CrossRef - Sex Differences in Cardiovascular Disease Risk by Socioeconomic Status (SES) of Workers Using National Health Information Database
Hosihn Ryu, Jihyun Moon, Jiyeon Jung International Journal of Environmental Research and Public Health.2020; 17(6): 2047. CrossRef - Impact of Mean and Variability of High‐Density Lipoprotein‐Cholesterol on the Risk of Myocardial Infarction, Stroke, and Mortality in the General Population
Byung‐Hun Han, Kyungdo Han, Kun‐Ho Yoon, Mee Kyoung Kim, Seung‐Hwan Lee Journal of the American Heart Association.2020;[Epub] CrossRef - Trends in the prevalence and treatment of bipolar affective disorder in South Korea
Yoon-Sun Jung, Young-Eun Kim, Arim Kim, Seok-Jun Yoon Asian Journal of Psychiatry.2020; 53: 102194. CrossRef - Social Inequalities of Oral Anticoagulation after the Introduction of Non-Vitamin K Antagonists in Patients with Atrial Fibrillation
Hee Tae Yu, Pil-Sung Yang, Jinseub Hwang, Soorack Ryu, Eunsun Jang, Tae-Hoon Kim, Jae-Sun Uhm, Jong-Youn Kim, Hui-Nam Pak, Moon-Hyoung Lee, Gregory Y.H. Lip, Boyoung Joung Korean Circulation Journal.2020; 50(3): 267. CrossRef - Increased incidence of bladder cancer with metabolically unhealthy status: analysis from the National Health Checkup database in Korea
Jong Wook Kim, Sun Tae Ahn, Mi Mi Oh, Du Geon Moon, Jun Cheon, Kyungdo Han, Seon Mee Kim, Hong Seok Park Scientific Reports.2020;[Epub] CrossRef - Prevalence and Current Management of Cardiovascular Risk Factors in Korean Adults Based on Fact Sheets
Eun-Jung Rhee Endocrinology and Metabolism.2020; 35(1): 85. CrossRef - Risk of type 2 diabetes according to the cumulative exposure to metabolic syndrome or obesity: A nationwide population‐based study
You‐Bin Lee, Da Hye Kim, Seon Mee Kim, Nan Hee Kim, Kyung Mook Choi, Sei Hyun Baik, Yong Gyu Park, Kyungdo Han, Hye Jin Yoo Journal of Diabetes Investigation.2020; 11(6): 1583. CrossRef - Sex differences in the blood pressure level associated with increased risks of cardiovascular events: a Korean nationwide population‐based cohort study
Youn Kyung Kee, Min‐ho Kim, Jongmin Oh, Hyung Jung Oh, Dong‐Ryeol Ryu The Journal of Clinical Hypertension.2020; 22(9): 1638. CrossRef - Fasting plasma glucose level and the risk of open angle glaucoma: Nationwide population-based cohort study in Korea
Jin A. Choi, Yong-Moon Park, Kyungdo Han, Jiyoung Lee, Jae-Seung Yun, Seung-Hyun Ko, Bang V Bui PLOS ONE.2020; 15(9): e0239529. CrossRef - Prognostic value of long-term gamma-glutamyl transferase variability in individuals with diabetes: a nationwide population-based study
Da Young Lee, Kyungdo Han, Ji Hee Yu, Sanghyun Park, Ji A Seo, Nam Hoon Kim, Hye Jin Yoo, Sin Gon Kim, Seon Mee Kim, Kyung Mook Choi, Sei Hyun Baik, Yong Gyu Park, Nan Hee Kim Scientific Reports.2020;[Epub] CrossRef - Predicting the Development of Myocardial Infarction in Middle-Aged Adults with Type 2 Diabetes: A Risk Model Generated from a Nationwide Population-Based Cohort Study in Korea
Seung-Hwan Lee, Kyungdo Han, Hun-Sung Kim, Jae-Hyoung Cho, Kun-Ho Yoon, Mee Kyoung Kim Endocrinology and Metabolism.2020; 35(3): 636. CrossRef - Exposure-weighted scoring for metabolic syndrome and the risk of myocardial infarction and stroke: a nationwide population-based study
Eun Young Lee, Kyungdo Han, Da Hye Kim, Yong-Moon Park, Hyuk-Sang Kwon, Kun-Ho Yoon, Mee Kyoung Kim, Seung-Hwan Lee Cardiovascular Diabetology.2020;[Epub] CrossRef - Outcomes in relation to antithrombotic therapy among patients with atrial fibrillation after percutaneous coronary intervention
Jiesuck Park, Eue-Keun Choi, Kyung-Do Han, Bongseong Kim, You-Jung Choi, So-Ryoung Lee, Jeehoon Kang, Myung-Jin Cha, Kyung Woo Park, Seil Oh, Gregory Y. H. Lip, Chun Chieh Yeh PLOS ONE.2020; 15(10): e0240161. CrossRef - Glucose variability and the risks of stroke, myocardial infarction, and all-cause mortality in individuals with diabetes: retrospective cohort study
Da Young Lee, Kyungdo Han, Sanghyun Park, Ji Hee Yu, Ji A. Seo, Nam Hoon Kim, Hye Jin Yoo, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Yong Gyu Park, Nan Hee Kim Cardiovascular Diabetology.2020;[Epub] CrossRef - Polypharmacy, hospitalization, and mortality risk: a nationwide cohort study
Tae Ik Chang, Haeyong Park, Dong Wook Kim, Eun Kyung Jeon, Connie M. Rhee, Kamyar Kalantar-Zadeh, Ea Wha Kang, Shin-Wook Kang, Seung Hyeok Han Scientific Reports.2020;[Epub] CrossRef - Effect of Variability in Blood Pressure, Glucose and Cholesterol Concentrations, and Body Weight on Emergency Hospitalization and 30‐Day Mortality in the General Population
Seung‐Hwan Lee, Kyungdo Han, Hyuk‐Sang Kwon, Kun‐Ho Yoon, Mee Kyoung Kim Journal of the American Heart Association.2020;[Epub] CrossRef - Incident cardiovascular disease and particulate matter air pollution in South Korea using a population-based and nationwide cohort of 0.2 million adults
Ok-Jin Kim, Soo Hyun Lee, Si-Hyuck Kang, Sun-Young Kim Environmental Health.2020;[Epub] CrossRef - Effects of BMI and LDL-cholesterol change pattern on cardiovascular disease in normal adults and diabetics
Tae Mi Youk, Min Jin Kang, Sun Ok Song, Eun-Cheol Park BMJ Open Diabetes Research & Care.2020; 8(2): e001340. CrossRef - Clinical Outcomes of COVID-19 Patients with Type 2 Diabetes: A Population-Based Study in Korea
Ji Hong You, Sang Ah Lee, Sung-Youn Chun, Sun Ok Song, Byung-Wan Lee, Dae Jung Kim, Edward J. Boyko Endocrinology and Metabolism.2020; 35(4): 901. CrossRef - Variability in estimated glomerular filtration rate and the incidence of type 2 diabetes: a nationwide population-based study
You-Bin Lee, Da Hye Kim, Eun Roh, So-Hyeon Hong, Jung A Kim, Hye Jin Yoo, Sei Hyun Baik, Kyungdo Han, Kyung Mook Choi BMJ Open Diabetes Research & Care.2020; 8(1): e001187. CrossRef - Appropriate Medical Technology in the Era of the 4th Industrial Revolution
Sang Youl Rhee The Korean Journal of Medicine.2019; 94(5): 387. CrossRef - Validation of diagnostic codes of major clinical outcomes in a National Health Insurance database
Jiesuck Park, Soonil Kwon, Eue-Keun Choi, You-jung Choi, Euijae Lee, Wonseok Choe, So-Ryoung Lee, Myung-Jin Cha, Woo-Hyun Lim, Seil Oh International Journal of Arrhythmia.2019;[Epub] CrossRef - Incidence of Prostate Cancer according to Metabolic Health Status: a Nationwide Cohort Study
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Ju Hee Han, Ji Hyun Lee, Kyung Do Han, Ha‐Na Kim, Chul Hwan Bang, Young Min Park, Jun Young Lee, Tae Yoon Kim The Journal of Dermatology.2019; 46(8): 695. CrossRef - Risk of Incident Dementia According to Metabolic Health and Obesity Status in Late Life: A Population-Based Cohort Study
Ji-Yeon Lee, Kyungdo Han, Eugene Han, Gyuri Kim, Hanna Cho, Kwang Joon Kim, Byung Wan Lee, Eun Seok Kang, Bong-Soo Cha, Carol Brayne, Yong-ho Lee The Journal of Clinical Endocrinology & Metabolism.2019; 104(7): 2942. CrossRef - Blood Pressure and Development of Cardiovascular Disease in Koreans With Type 2 Diabetes Mellitus
Mee Kyoung Kim, Kyungdo Han, Eun Sil Koh, Eun Sook Kim, Min-Kyung Lee, Ga Eun Nam, Hyuk-Sang Kwon Hypertension.2019; 73(2): 319. CrossRef - Association between BMI and risk of severe hypoglycaemia in type 2 diabetes
J.-S. Yun, Y.-M. Park, K. Han, S.-A. Cha, Y.-B. Ahn, S.-H. Ko Diabetes & Metabolism.2019; 45(1): 19. CrossRef - Effects of Variability in Blood Pressure, Glucose, and Cholesterol Concentrations, and Body Mass Index on End-Stage Renal Disease in the General Population of Korea
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Hyunsoo Chung, Su Young Kim, Hyun-Soo Kim The Korean Journal of Medicine.2019; 94(6): 463. CrossRef - Obesity Fact Sheet in Korea, 2018: Data Focusing on Waist Circumference and Obesity-Related Comorbidities
Ga Eun Nam, Yang-Hyun Kim, Kyungdo Han, Jin-Hyung Jung, Yong Gyu Park, Kwan-Woo Lee, Eun-Jung Rhee, Jang Won Son, Seong-Su Lee, Hyuk-Sang Kwon, Won-Young Lee, Soon Jib Yoo Journal of Obesity & Metabolic Syndrome.2019; 28(4): 236. CrossRef - Risk of end‐stage renal disease from chronic kidney disease defined by decreased glomerular filtration rate in type 1 diabetes: A comparison with type 2 diabetes and the effect of metabolic syndrome
You‐Bin Lee, Kyungdo Han, Bongsung Kim, Ji Eun Jun, Seung‐Eun Lee, Jiyeon Ahn, Gyuri Kim, Sang‐Man Jin, Jae Hyeon Kim Diabetes/Metabolism Research and Reviews.2019;[Epub] CrossRef - Weight change and mortality and cardiovascular outcomes in patients with new-onset diabetes mellitus: a nationwide cohort study
Mee Kyoung Kim, Kyungdo Han, Eun Sil Koh, Eun Sook Kim, Min-Kyung Lee, Ga Eun Nam, Hyuk-Sang Kwon Cardiovascular Diabetology.2019;[Epub] CrossRef - Risk of early mortality and cardiovascular disease in type 1 diabetes: a comparison with type 2 diabetes, a nationwide study
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Jung A Kim, Da Hye Kim, Seon Mee Kim, Yong Gyu Park, Nan Hee Kim, Sei Hyun Baik, Kyung Mook Choi, Kyungdo Han, Hye Jin Yoo Endocrinology and Metabolism.2019; 34(4): 406. CrossRef - The protective effect of klotho against contrast-associated acute kidney injury via the antioxidative effect
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Inki Moon, Eue-Keun Choi, Jin-Hyung Jung, Kyung-Do Han, You-Jung Choi, Jiesuck Park, Jun Hwan Cho, Euijae Lee, Wonseok Choe, So-Ryoung Lee, Myung-Jin Cha, Woo-Hyun Lim, Seil Oh International Journal of Cardiology.2019; 275: 77. CrossRef - Impact of Cytomegalovirus Disease on New-Onset Type 2 Diabetes Mellitus: Population-Based Matched Case-Control Cohort Study
Seul Gi Yoo, Kyung Do Han, Kyoung Hwa Lee, Yeonju La, Da Eun Kwon, Sang Hoon Han Diabetes & Metabolism Journal.2019; 43(6): 815. CrossRef - Body Mass Index Variability and Long-term Risk of New-Onset Atrial Fibrillation in the General Population: A Korean Nationwide Cohort Study
Yeong-Min Lim, Pil-Sung Yang, Eunsun Jang, Hee Tae Yu, Tae-Hoon Kim, Jae-Sun Uhm, Jong-Youn Kim, Hui-Nam Pak, Moon-Hyoung Lee, Boyoung Joung, Gregory Y.H. Lip Mayo Clinic Proceedings.2019; 94(2): 225. CrossRef - Effect of hypertension duration and blood pressure level on ischaemic stroke risk in atrial fibrillation: nationwide data covering the entire Korean population
Tae-Hoon Kim, Pil-Sung Yang, Hee Tae Yu, Eunsun Jang, Hyejung Shin, Ha Yan Kim, Jae-Sun Uhm, Jong-Youn Kim, Jung-Hoon Sung, Hui-Nam Pak, Moon-Hyoung Lee, Boyoung Joung, Gregory Y H Lip European Heart Journal.2019; 40(10): 809. CrossRef - Increased Risk of Diabetes in Inflammatory Bowel Disease Patients: A Nationwide Population-Based Study in Korea
Eun Ae Kang, Kyungdo Han, Jaeyoung Chun, Hosim Soh, Seona Park, Jong Pil Im, Joo Sung Kim Journal of Clinical Medicine.2019; 8(3): 343. CrossRef - High Proportion of Adult Cases and Prevalence of Metabolic Syndrome in Type 1 Diabetes Mellitus Population in Korea: A Nationwide Study
You-Bin Lee, Kyungdo Han, Bongsung Kim, Sang-Man Jin, Seung-Eun Lee, Ji Eun Jun, Jiyeon Ahn, Gyuri Kim, Jae Hyeon Kim Diabetes & Metabolism Journal.2019; 43(1): 76. CrossRef - Long-term evolution of direct healthcare costs for inflammatory bowel diseases: a population-based study (2006–2015)
Jung-Wook Kim, Chang Kyun Lee, Jung Kuk Lee, Su Jin Jeong, Shin Ju Oh, Jung Rock Moon, Hyun-Soo Kim, Hyo Jong Kim Scandinavian Journal of Gastroenterology.2019; 54(4): 419. CrossRef - Association Between Systolic and Diastolic Blood Pressure Variability and the Risk of End-Stage Renal Disease
Eun Hui Bae, Sang Yup Lim, Kyung-Do Han, Tae Ryom Oh, Hong Sang Choi, Chang Seong Kim, Seong Kwon Ma, Soo Wan Kim Hypertension.2019; 74(4): 880. CrossRef - Effect of Dipeptidyl Peptidase-4 Inhibitors on the Risk of Bone Fractures in a Korean Population
Morena Ustulin, So Young Park, Hangseok Choi, Suk Chon, Jeong-Taek Woo, Sang Youl Rhee Journal of Korean Medical Science.2019;[Epub] CrossRef - Temporal trends in prevalence and antithrombotic treatment among Asians with atrial fibrillation undergoing percutaneous coronary intervention: A nationwide Korean population-based study
Jiesuck Park, Eue-Keun Choi, Kyung-Do Han, You-jung Choi, Euijae Lee, Wonseok Choe, So-Ryoung Lee, Myung-Jin Cha, Woo-Hyun Lim, Jeehoon Kang, Kyung Woo Park, Seil Oh, Gregory Y. H. Lip, Chiara Lazzeri PLOS ONE.2019; 14(1): e0209593. CrossRef - Severe hypoglycemia and the risk of cardiovascular disease and mortality in type 2 diabetes: a nationwide population-based cohort study
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Yun-Kyung Kim, Joon Young Song, Hyeongap Jang, Tae Hyun Kim, Heejo Koo, Lijoy Varghese, Euna Han PharmacoEconomics.2018; 36(12): 1475. CrossRef - Trends in the prevalence of metabolic syndrome and its components in South Korea: Findings from the Korean National Health Insurance Service Database (2009–2013)
Seung Eun Lee, Kyungdo Han, Yu Mi Kang, Seon-Ok Kim, Yun Kyung Cho, Kyung Soo Ko, Joong-Yeol Park, Ki-Up Lee, Eun Hee Koh, Ying-Mei Feng PLOS ONE.2018; 13(3): e0194490. CrossRef - Appropriate Amount of Regular Exercise Is Associated with a Reduced Mortality Risk
DA YOUNG LEE, EUN-JUNG RHEE, JUNG HWAN CHO, HYEMI KWON, SE EUN PARK, YANG-HYUN KIM, KYUNGDO HAN, YONG-KYU PARK, SOON JIB YOO, WON-YOUNG LEE Medicine & Science in Sports & Exercise.2018; 50(12): 2451. CrossRef - Association of blood pressure components with mortality and cardiovascular events in prehypertensive individuals: a nationwide population-based cohort study
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Su Jeong Song, Kyungdo Han, Kyung Seek Choi, Seung‐Hyun Ko, Eun‐jung Rhee, Cheol‐Young Park, Joong‐Yeol Park, Ki‐Up Lee, Kyung‐Soo Ko Journal of Diabetes Investigation.2018; 9(1): 173. CrossRef - Optimal Blood Pressure in Elderly Hypertensive Subjects: A Korean National Health Insurance Service Health Examinee Cohort Study
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- Glycated Hemoglobin Value for Fasting Plasma Glucose of 126 mg/dL in Korean: The 2011 Korea National Health and Nutrition Examination Survey
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Jung Min Kim, Jae Won Hong, Jong Chul Won, Jung Hyun Noh, Kyung Soo Ko, Byoung Doo Rhee, Dong-Jun Kim
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Diabetes Metab J. 2014;38(6):480-483. Published online December 15, 2014
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DOI: https://doi.org/10.4093/dmj.2014.38.6.480
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Abstract
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We aimed to estimate the cutoff value of glycated hemoglobin (HbA1c, A1c) for fasting plasma glucose (FPG) of 126 mg/dL in the Korean adult population, using the 2011 Korea National Health and Nutrition Examination Survey. A total of 5,421 participants without a history of diabetes and over 19 years of age were included in the analysis. A point-wise area under the receiver operating characteristic curve was used to estimate the optimal A1c cutoff value. A1c threshold of 6.1% produced the highest sum of sensitivity (85.2%) and specificity (90.5%) for FPG of 126 mg/dL (area under the curve, 0.941, P<0.001). A1c of 6.5% produced a sensitivity of 67.7% and specificity of 98.0% for FPG of 126 mg/dL. Considering A1c as one of three criteria for the diagnosis of diabetes and the specificity of an A1c cutoff of 6.5%, the current diagnostic criteria of A1c≥6.5% might be acceptable in the Korean adult population.
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- 2023 Clinical Practice Guidelines for Diabetes Management in Korea: Full Version Recommendation of the Korean Diabetes Association
Jun Sung Moon, Shinae Kang, Jong Han Choi, Kyung Ae Lee, Joon Ho Moon, Suk Chon, Dae Jung Kim, Hyun Jin Kim, Ji A Seo, Mee Kyoung Kim, Jeong Hyun Lim, Yoon Ju Song, Ye Seul Yang, Jae Hyeon Kim, You-Bin Lee, Junghyun Noh, Kyu Yeon Hur, Jong Suk Park, Sang Diabetes & Metabolism Journal.2024; 48(4): 546. CrossRef - The Effect of an Empowerment Program on the Perceived Risk and Physical Health of Patients With Coronary Artery Disease
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Sangmo Hong, Jun Goo Kang, Chul Sik Kim, Seong Jin Lee, Cheol-Young Park, Chang Beom Lee, Sung-Hee Ihm Diabetes & Metabolism Journal.2016; 40(2): 167. CrossRef - Is an Oral Glucose Tolerance Test Still Valid for Diagnosing Diabetes Mellitus?
Dong-Lim Kim, Sun-Doo Kim, Suk Kyeong Kim, Sooyoun Park, Kee-Ho Song Diabetes & Metabolism Journal.2016; 40(2): 118. CrossRef - Comparison of the clinical characteristics of diabetes mellitus diagnosed using fasting plasma glucose and haemoglobin A1c: The 2011 Korea National Health and Nutrition Examination Survey
Sangmo Hong, Jun Goo Kang, Chul Sik Kim, Seong Jin Lee, Chang Beom Lee, Sung-Hee Ihm Diabetes Research and Clinical Practice.2016; 113: 23. CrossRef - Effects of diabetes definition on global surveillance of diabetes prevalence and diagnosis: a pooled analysis of 96 population-based studies with 331 288 participants
G Danaei, S Fahimi, Y Lu, B Zhou, K Hajifathalian, M Di Cesare, WC Lo, B Reis-Santos, MJ Cowan, JE Shaw, J Bentham, JK Lin, H Bixby, D Magliano, P Bovet, JJ Miranda, YH Khang, GA Stevens, LM Riley, MK Ali, M Ezzati, ZA Abdeen, KA Kadir, M Abu-Rmeileh, B A The Lancet Diabetes & Endocrinology.2015; 3(8): 624. CrossRef - The Optimal Cutoff Value of Glycated Hemoglobin for Detection of Diabetic Retinopathy
Jung Min Kim, Dong-Jun Kim Diabetes & Metabolism Journal.2015; 39(1): 16. CrossRef
- Background and Data Configuration Process of a Nationwide Population-Based Study Using the Korean National Health Insurance System
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Sun Ok Song, Chang Hee Jung, Young Duk Song, Cheol-Young Park, Hyuk-Sang Kwon, Bong Soo Cha, Joong-Yeol Park, Ki-Up Lee, Kyung Soo Ko, Byung-Wan Lee
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Diabetes Metab J. 2014;38(5):395-403. Published online October 17, 2014
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DOI: https://doi.org/10.4093/dmj.2014.38.5.395
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- Background
The National Health Insurance Service (NHIS) recently signed an agreement to provide limited open access to the databases within the Korean Diabetes Association for the benefit of Korean subjects with diabetes. Here, we present the history, structure, contents, and way to use data procurement in the Korean National Health Insurance (NHI) system for the benefit of Korean researchers. MethodsThe NHIS in Korea is a single-payer program and is mandatory for all residents in Korea. The three main healthcare programs of the NHI, Medical Aid, and long-term care insurance (LTCI) provide 100% coverage for the Korean population. The NHIS in Korea has adopted a fee-for-service system to pay health providers. Researchers can obtain health information from the four databases of the insured that contain data on health insurance claims, health check-ups and LTCI. ResultsMetabolic disease as chronic disease is increasing with aging society. NHIS data is based on mandatory, serial population data, so, this might show the time course of disease and predict some disease progress, and also be used in primary and secondary prevention of disease after data mining. ConclusionThe NHIS database represents the entire Korean population and can be used as a population-based database. The integrated information technology of the NHIS database makes it a world-leading population-based epidemiology and disease research platform.
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Yongjae Yoo, Joo Hyeon Oh, Haine Lee, Hyunsook Choi, Somin Joo, Andrew Hogyu Han, Jee Youn Moon Pain Medicine.2023; 24(1): 79. CrossRef - Epidemiology of idiopathic sudden sensorineural hearing loss in the era of big data
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Siin Kim, Hae Sun Suh International Journal of Drug Policy.2023; 112: 103953. CrossRef - The effects of sociodemographic factors on help-seeking for depression: Based on the 2017–2020 Korean Community Health Survey
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Sanghyun Oh, Jihwan Lee, Yoo S Hong, Kyuwoong Kim European Journal of Preventive Cardiology.2023; 30(8): 670. CrossRef - Association between familial aggregation of chronic kidney disease and its incidence and progression
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Siin Kim, Hae Sun Suh Journal of Clinical Medicine.2023; 12(8): 2860. CrossRef - Trends in the Incidence and Etiology of Non-Traumatic Spinal Cord Injury in Korea: A Nationwide Population-Based Study From 2007 to 2020
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Dayong Lee, Taek Sang Lee Journal of Clinical Medicine.2023; 12(8): 2954. CrossRef - Long‐term adverse neurodevelopmental outcomes of discordant twins delivered at term: A nationwide population‐based study
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Young Ju Choi, Kyungdo Han, Won Kyoung Cho, Min Ho Jung, Byung-Kyu Suh Clinical Epidemiology.2023; Volume 15: 535. CrossRef - Association of Waist Circumference with the Risk of Inflammatory Bowel Disease: a Nationwide Cohort Study of 10 Million Individuals in Korea
Yeonjin Je, Kyungdo Han, Jaeyoung Chun, Yuna Kim, Jie-Hyun Kim, Young Hoon Youn, Hyojin Park, Jong Pil Im, Joo Sung Kim Journal of Crohn's and Colitis.2023; 17(5): 681. CrossRef - Lifestyle factors and long-term survival in patients with chronic non-cancer pain: a nationwide cohort study in South Korea
Tak Kyu Oh, In-Ae Song Journal of Anesthesia.2023; 37(4): 522. CrossRef - Long term renal outcome after hypertensive disease during pregnancy: a nationwide population-based study
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Bokyung Kim, Kyungdo Han, Hyunsoo Chung, Sang Gyun Kim, Soo‐Jeong Cho Cancer.2023; 129(18): 2893. CrossRef - Acute Pancreatitis and the Risk of Dementia in Diabetes: A Nationwide Cohort Study Using Korean Healthcare Claims Database
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Zhi Da Soh, Ching-Yu Cheng Taiwan Journal of Ophthalmology.2023; 13(2): 123. CrossRef - Impact of mental disorders on the risk of heart failure among Korean patients with diabetes: a cohort study
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Sangmo Hong, Kyungdo Han, Jung Hwan Park, Sung Hoon Yu, Chang Beom Lee, Dong Sun Kim Journal of Lipid and Atherosclerosis.2023; 12(2): 164. CrossRef - Impact of Allergic Disease on the Risk of Mycobacterial Disease
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Kyeong Ik Na, Won June Lee, Young Kook Kim Journal of Korean Medical Science.2023;[Epub] CrossRef - Association between regular physical activity and lower incidence of colorectal cancer in patients with diabetes mellitus: a nationwide cohort study
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Jin Su Jang, Hyun Woo Jung BMC Health Services Research.2023;[Epub] CrossRef - Long-term clinical outcomes of tricuspid valve replacement using bovine versus porcine valves: a nationwide population-based study
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Inha Jung, Kyung-Do Han, Sun Joon Moon, Hyemi Kwon, Se Eun Park, Eun-Jung Rhee, Won-Young Lee Diabetes Research and Clinical Practice.2023; 202: 110819. CrossRef - The Association Between Institutional Case Volume of Hematopoietic Stem Cell Transplantation and Mortality
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Jung-Hyun Park, Hyungwoo Lee, Jin-Woo Kim, Tae-Jin Song BMC Oral Health.2023;[Epub] CrossRef - Trends in the incidence and prevalence of dysphagia requiring medical attention among adults in South Korea, 2006–2016: A nationwide population study
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Jae Woo Choi Tobacco Induced Diseases.2023; 21(July): 1. CrossRef - A cohort study found a high risk of end-stage kidney disease associated with acromegaly
Sangmo Hong, Kyung-Soo Kim, Kyungdo Han, Cheol-Young Park Kidney International.2023; 104(4): 820. CrossRef - Comparative cardiovascular outcomes in type 2 diabetes patients taking dapagliflozin versus empagliflozin: a nationwide population-based cohort study
Jaehyun Lim, You-Jung Choi, Bong Sung Kim, Tae-Min Rhee, Hyun-Jung Lee, Kyung-Do Han, Jun-Bean Park, Jin Oh Na, Yong-Jin Kim, Heesun Lee, Hyung-Kwan Kim Cardiovascular Diabetology.2023;[Epub] CrossRef - Effects of Statin Treatment on the Development of Tendinopathy: A Nationwide Population-Based Cohort Study
Donghee Kwak, Seok-joo Moon, Jong Woong Park, Duk Hee Lee, Jung Il Lee Orthopaedic Journal of Sports Medicine.2023;[Epub] CrossRef - Incident dementia in kidney transplantation recipients: a matched comparative nationwide cohort study in South Korea
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Ji Min Lee, Kyungdo Han, Kang-Moon Lee, Jae-Seung Yun Journal of Korean Medical Science.2023;[Epub] CrossRef - Sex differences in mortality in patients with acromegaly: a nationwide cohort study in Korea
Jiwon Kim, Namki Hong, Jimi Choi, Ju Hyung Moon, Eui Hyun Kim, Jae Won Hong, Eun Jig Lee, Sin Gon Kim, Cheol Ryong Ku European Journal of Endocrinology.2023; 189(2): 225. CrossRef - Proton pump inhibitor use and the risk of metachronous gastric cancer after H. pylori eradication in patients who underwent endoscopic resection for gastric neoplasms: A population‐based cohort study
Eun Jeong Gong, Hye‐Kyung Jung, Bora Lee, Jitaek Hong, Jong Wook Kim, Cheol Min Shin, Young Hoon Youn, Kwang Jae Lee Alimentary Pharmacology & Therapeutics.2023; 58(7): 668. CrossRef - National Trends in Rotavirus Enteritis among Infants in South Korea, 2010–2021: A Nationwide Cohort
Hyun Jee Lee, Yujin Choi, Jaeyu Park, Yong-Sung Choi, Dong Keon Yon, Do Hyun Kim Children.2023; 10(9): 1436. CrossRef - Impact of Concomitant Use of Proton Pump Inhibitors and Clopidogrel on Recurrent Stroke and Myocardial Infarction
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Tak Kyu Oh, Hye Yoon Park, In-Ae Song Psychiatry Investigation.2023; 20(9): 834. CrossRef - Increased risk of venous and arterial thromboembolism in patients with colorectal cancer receiving cetuximab-based combination chemotherapy: A population-based study in Korea
Ho-Young Yhim, Juhyun Lee, Kyoung Ha Kim, Sang-A Kim, Ji Yun Lee, Hun-Gyu Hwang, Junshik Hong, Jeong-Ok Lee, Soo-Mee Bang Thrombosis Research.2023; 231: 50. CrossRef - Volatile Anesthetic Use Versus Total Intravenous Anesthesia for Patients Undergoing Heart Valve Surgery: A Nationwide Population-Based Study
Jae-Woo Ju, Ho-Jin Lee, Karam Nam, Seungwook Kim, Hyunsook Hong, Seung Ho Yoo, Seohee Lee, Youn Joung Cho, Yunseok Jeon Anesthesia & Analgesia.2023;[Epub] CrossRef - Incidence, Morbidity, and Mortality of Achalasia: A Nationwide, Population-Based Cohort Study in South Korea
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Tae Kyung Yoo, Kyung-Do Han, Yang-Hyun Kim, Ga Eun Nam, Sang Hyun Park, Eun-Jung Rhee, Won-Young Lee Diabetes & Metabolism Journal.2023; 47(6): 846. CrossRef - Association between preoperative modifiable lifestyle factors and mortality after cancer surgery: a population-based cohort study in South Korea
Tak Kyu Oh, In-Ae Song Annals of Surgical Treatment and Research.2023; 105(4): 179. CrossRef - Classification of long-term clinical course of Parkinson’s disease using clustering algorithms on social support registry database
Dougho Park, Su Yun Lee, Jong Hun Kim, Hyoung Seop Kim Journal of Big Data.2023;[Epub] CrossRef - Association between Proteinuria Status and Risk of Hypertension: A Nationwide Population-Based Cohort Study
Hyungwoo Lee, Moo-Suk Park, Min Kyoung Kang, Tae-Jin Song Journal of Personalized Medicine.2023; 13(9): 1414. CrossRef - Association of physical activity with the risk of Parkinson's disease in depressive disorder: A nationwide longitudinal cohort study
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Hye Hyeon Kim, Jin Hyuk Lee, In Han Song, Yu Rang Park Psychiatry Research.2023; 330: 115613. CrossRef - Association Between Premature Menopause and Cardiovascular Diseases and All‐Cause Mortality in Korean Women
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Jae Hyun Kim, Gaeun Lee, Jinseub Hwang, Ji‐Won Kim, Jin‐Won Kwon, Yun‐Kyoung Song Journal of the American Heart Association.2023;[Epub] CrossRef - Impact of Propofol-based Total Intravenous Anesthesia Versus Inhalation Anesthesia on Long-term Survival After Cancer Surgery in a Nationwide Cohort
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Dong Hwan Lee, Hwa Sung Lee, Soo Hyun Jang, Jun-Young Heu, Kyungdo Han, Se-Won Lee Journal of Clinical Medicine.2023; 13(1): 92. CrossRef - Cost-effectiveness of the anti-vascular endothelial growth factor intravitreal injection and panretinal photocoagulation for patients with proliferative diabetic retinopathy in South Korea
Hyeon-Jeong Lee, Songhee Cho, Jungeun Park, Yan Jin, Hyung Min Kim, Donghyun Jee BMC Health Services Research.2023;[Epub] CrossRef - Prior Evaluation of Nutritional Status and Mortality in Patients with Sepsis in South Korea
Tak Kyu Oh, In-Ae Song Nutrients.2023; 15(24): 5040. CrossRef - Increased Risk of Hip Fracture in Patients with Acromegaly: A Nationwide Cohort Study in Korea
Jiwon Kim, Namki Hong, Jimi Choi, Ju Hyung Moon, Eui Hyun Kim, Eun Jig Lee, Sin Gon Kim, Cheol Ryong Ku Endocrinology and Metabolism.2023; 38(6): 690. CrossRef - Cancer risks in patients with ankylosing spondylitis and the effects of biologic agents: a population-based study
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So-Ryoung Lee, Soonil Kwon, Eue-Keun Choi, Jin-Hyung Jung, Kyung-Do Han, Seil Oh, Gregory Y. H. Lip Cardiovascular Drugs and Therapy.2022; 36(4): 679. CrossRef - Institutional case volume-incorporated mortality risk prediction model for cardiac surgery
Seohee Lee, Eun Jin Jang, Junwoo Jo, Dongnyeok Park, Ho Geol Ryu Asian Journal of Surgery.2022; 45(1): 189. CrossRef - Does Surgical Ablation of Atrial Fibrillation Benefit Patients Undergoing Bioprosthetic Valve Replacement?
Won Kyung Pyo, Ho Jin Kim, Joon Bum Kim, Sung-Ho Jung, Suk Jung Choo, Cheol Hyun Chung, Jae Won Lee Seminars in Thoracic and Cardiovascular Surgery.2022; 34(3): 906. CrossRef - Burden of comorbidities and medication use in childbearing women with rheumatic diseases: a nationwide population-based study
Min Kyung Chung, Chan Hee Lee, Jin Su Park, Hyunsun Lim, Jisoo Lee The Korean Journal of Internal Medicine.2022; 37(6): 1250. CrossRef - Validation of Dynamic Aspartate‐to–Alanine Aminotransferase Ratio for Predicting Liver Disease Mortality
In‐Ae Song, Eun Sun Jang, Tak Kyu Oh Hepatology Communications.2022; 6(4): 740. CrossRef - Blood Pressure Levels and Risks of Dementia: a Nationwide Study of 4.5 Million People
Chan Joo Lee, Ji-Yeon Lee, Kyungdo Han, Da Hye Kim, Hanna Cho, Kwang Joon Kim, Eun Seok Kang, Bong-Soo Cha, Yong-ho Lee, Sungha Park Hypertension.2022; 79(1): 218. CrossRef - Continuing regular physical activity and maintaining body weight have a synergistic interaction in improving survival: a population-based cohort study including 6.5 million people
Chang-Hoon Lee, Kyung-Do Han, Da Hye Kim, Min-Sun Kwak European Journal of Preventive Cardiology.2022; 29(3): 547. CrossRef - Liver enzymes and risk of ocular motor cranial nerve palsy: a nationwide population-based study
Joonhyoung Kim, Kyungdo Han, Juhwan Yoo, Kyung-Ah Park, Sei Yeul Oh Neurological Sciences.2022; 43(5): 3395. CrossRef - Underutilisation of prophylactic G-CSF in breast cancer patients receiving adjuvant docetaxel/cyclophosphamide chemotherapy
Minhee Ku, Nam Kyung Je Journal of Chemotherapy.2022; 34(8): 534. CrossRef - Epidemiologic study of bladder and urethral injury in Korea: A nationwide population-based study
Bum Sik Tae, Young Eun Yoon, Woong Na, Kyung Jin Oh, Sung Yul Park, Jae Young Park, Hong Sang Moon Investigative and Clinical Urology.2022; 63(1): 92. CrossRef - Acromegaly and cardiovascular outcomes: a cohort study
Sangmo Hong, Kyung-Soo Kim, Kyungdo Han, Cheol-Young Park European Heart Journal.2022; 43(15): 1491. CrossRef - Pericardial Versus Porcine Valves for Surgical Aortic Valve Replacement
Hong Ju Shin, Wan Kee Kim, Jin Kyoung Kim, Joon Bum Kim, Sung-Ho Jung, Suk Jung Choo, Cheol Hyun Chung, Jae Won Lee Korean Circulation Journal.2022; 52(2): 136. CrossRef - Effect of obesity and metabolic health on urolithiasis: A nationwide population-based study
Changil Choi, Jong Keun Kim, Kyungdo Han, Young Goo Lee, Jun Hyun Han Investigative and Clinical Urology.2022; 63(1): 63. CrossRef - Comprehensive risk assessment for hospital-acquired pneumonia: sociodemographic, clinical, and hospital environmental factors associated with the incidence of hospital-acquired pneumonia
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Won Kyung Pyo, Ho Jin Kim, Joon Bum Kim, Sung-Ho Jung, Suk Jung Choo, Cheol Hyun Chung, Jae Won Lee Korean Circulation Journal.2021; 51(6): 504. CrossRef - Analysis of application of dental sedation in attention deficit hyperactivity disorder (ADHD) patients using the Korean National Health Insurance data
Seong In Chi, Hyuk Kim, Kwang-Suk Seo Journal of Dental Anesthesia and Pain Medicine.2021; 21(2): 99. CrossRef - Deep Spinal Infection after Outpatient Epidural Injections for Pain: A Retrospective Sample Cohort Study Using a Claims Database in South Korea
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Tak Kyu Oh, In-Ae Song Cancer Epidemiology, Biomarkers & Prevention.2021; 30(7): 1440. CrossRef - Association of mortality with drug-coated devices in femoropopliteal artery based on the nationwide data
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S Lee, S-W Choi, J Kim, H M Lee, S-J Oh, S-K Kong The Journal of Laryngology & Otology.2021; 135(8): 695. CrossRef - Clinical Study Using Healthcare Claims Database
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Dong Hyun Sinn, Danbee Kang, Yun Soo Hong, Kwang Cheol Koh, Eliseo Guallar, Juhee Cho, Geum-Youn Gwak, Luca Rinaldi PLOS ONE.2021; 16(8): e0255624. CrossRef - Relationship between total cholesterol level and tuberculosis risk in a nationwide longitudinal cohort
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Ho-Geol Woo, Yoon-Kyung Chang, Ji-Sung Lee, Tae-Jin Song Medicina.2021; 57(9): 910. CrossRef - Synergistic harmful interaction between sustained physical inactivity and hypertension/diabetes mellitus on the risk of all-cause mortality: a retrospective observational cohort study
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Bumhee Yang, Kyungdo Han, Sang Hyuk Kim, Dong-Hwa Lee, Sang Hyun Park, Jung Eun Yoo, Dong Wook Shin, Hayoung Choi, Hyun Lee Nutrients.2021; 13(9): 3206. CrossRef - Particular matter influences the incidence of acute otitis media in children
Mina Park, Jiyeon Han, Jiwon Park, Myoung-jin Jang, Moo Kyun Park Scientific Reports.2021;[Epub] CrossRef - Changes in the Prosthesis Types Used for Aortic Valve Replacement after the Introduction of Sutureless and Rapid Deployment Valves in Korea: A Nationwide Population-Based Cohort Study
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Jaehoon Lee, Yuntae Kim, Hyunji Park, Changsoo Kim, Sihyun Cho, Jongyoun Kim Journal of Clinical Medicine.2021; 10(23): 5497. CrossRef - Rheumatoid Arthritis in Silica-Exposed Workers
Young-Sun Min, Min-Gi Kim, Yeon-Soon Ahn International Journal of Environmental Research and Public Health.2021; 18(23): 12776. CrossRef - Changes in metabolic syndrome and risk of psoriasis: a nationwide population-based study
Hyun Ji Lee, Kyung Do Han, Hae Eun Park, Ju Hee Han, Chul Hwan Bang, Young Min Park, Ji Hyun Lee Scientific Reports.2021;[Epub] CrossRef - Fasting Glucose Variability as a Risk Indicator for End-Stage Kidney Disease in Patients with Diabetes: A Nationwide Population-Based Study
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Young Su Joo, Jong Hyun Jhee, Hyung-Woo Kim, Seung Hyeok Han, Tae-Hyun Yoo, Shin-Wook Kang, Jung Tak Park Aging.2020; 12(17): 17393. CrossRef - Association Between Income Disparities and Risk of Chronic Kidney Disease
Tae Ik Chang, Hyunsun Lim, Cheol Ho Park, Connie M. Rhee, Kamyar Kalantar-Zadeh, Ea Wha Kang, Shin-Wook Kang, Seung Hyeok Han Mayo Clinic Proceedings.2020; 95(2): 231. CrossRef - Pre-transplant depression decreased overall survival of patients receiving allogeneic hematopoietic stem cell transplantation: a nationwide cohort study
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H‐Y Moon, M‐r Kim, D‐S Hwang, J‐B Jang, J Lee, J‐S Shin, I Ha, YJ Lee BJOG: An International Journal of Obstetrics & Gynaecology.2020; 127(1): 79. CrossRef - Bell’s palsy and obesity, alcohol consumption and smoking: A nested case-control study using a national health screening cohort
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Da Young Lee, Kyungdo Han, Ji Hee Yu, Sanghyun Park, Ji A Seo, Nam Hoon Kim, Hye Jin Yoo, Sin Gon Kim, Seon Mee Kim, Kyung Mook Choi, Sei Hyun Baik, Yong Gyu Park, Nan Hee Kim Scientific Reports.2020;[Epub] CrossRef - Trends and risk factors of elderly-onset Crohn’s disease: A nationwide cohort study
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Yoonkyung Chang, Ji Sung Lee, Ki-Jung Lee, Ho Geol Woo, Tae-Jin Song Diabetologia.2020; 63(5): 924. CrossRef - Development of stroke identification algorithm for claims data using the multicenter stroke registry database
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Hyun-Jung Lee, Eue-Keun Choi, Kyung-Do Han, Euijae Lee, Inki Moon, So-Ryoung Lee, Myung-Jin Cha, Seil Oh, Gregory Y.H. Lip Heart Rhythm.2020; 17(3): 365. CrossRef - Longitudinal Study of Diabetic Differences between International Migrants and Natives among the Asian Population
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Sangmo Hong, Kyungdo Han, Cheol-Young Park Mayo Clinic Proceedings.2020; 95(1): 101. CrossRef - Impact of Mean and Variability of High‐Density Lipoprotein‐Cholesterol on the Risk of Myocardial Infarction, Stroke, and Mortality in the General Population
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Yang-Hyun Kim, Jun Goo Kang, Seong Jin Lee, Kyung-do Han, Sung-Hee Ihm, Kyung-Hwan Cho, Yong-Gyu Park Diabetes Care.2020; 43(5): 1118. CrossRef - Pneumonia risk and its associated factors in Parkinson's disease: A National Database Study
Jun Hee Won, Seong Jun Byun, Byung-Mo Oh, Han-Joon Kim, Sang Jun Park, Han Gil Seo Journal of the Neurological Sciences.2020; 415: 116949. CrossRef - The Association with rhegmatogenous retinal detachment and paediatric atopic dermatitis: a 12-year Nationwide Cohort Study
M. Choi, S. J. Byun, D. H. Lee, K. H. Kim, K. H. Park, S. J. Park Eye.2020; 34(10): 1909. CrossRef Peripartum Blood Transfusions are Associated with Increased Risk of Cancer: A National Retrospective Cohort Study Geum Joon Cho, Michael S Oh, Min-Jeong Oh, Keon Vin Park, Sung Won Han, Young Kwang Chae Clinical Epidemiology.2020; Volume 12: 659. CrossRef- The Burden of Cervical Cancer in Korea: A Population-Based Study
Jinhee Kim, Donghwan Lee, Kyung-Bok Son, SeungJin Bae International Journal of Environmental Research and Public Health.2020; 17(17): 6308. CrossRef - Temporal trends of catheter ablation for patients with atrial fibrillation: A Korean nationwide population‐based study
Euijae Lee, So‐Ryoung Lee, Eue‐Keun Choi, Kyung‐Do Han, Myung‐Jin Cha, Gregory Y.H. Lip, Seil Oh Journal of Cardiovascular Electrophysiology.2020; 31(10): 2616. CrossRef - Trend of prevalence and incidence of systemic lupus erythematosus in South Korea, 2005 to 2015: a nationwide population-based study
Eun Hui Bae, Sang Yeob Lim, Kyung-Do Han, Jin-Hyung Jung, Hong Sang Choi, Ha Yeon Kim, Chang Seong Kim, Seong Kwon Ma, Soo Wan Kim The Korean Journal of Internal Medicine.2020; 35(3): 652. CrossRef - Achievement of the low-density lipoprotein cholesterol goal among patients with dyslipidemia in South Korea
Siin Kim, Sola Han, Pratik P. Rane, Yi Qian, Zhongyun Zhao, Hae Sun Suh, Luigina Guasti PLOS ONE.2020; 15(1): e0228472. CrossRef - Oral health and gastrointestinal cancer: A nationwide cohort study
Kijeong Lee, Ji Sung Lee, Jinkwon Kim, Huisong Lee, Yoonkyung Chang, Ho Geol Woo, Jin‐Woo Kim, Tae‐Jin Song Journal of Clinical Periodontology.2020; 47(7): 796. CrossRef - Site-specific cancer risk in patients with type 2 diabetes: a nationwide population-based cohort study in Korea
Suk Kyeong Kim, Ju-Young Jang, Dong-Lim Kim, Young A Rhyu, Suh Eun Lee, Seung-Hyun Ko, Kyungdo Han, Kee-Ho Song The Korean Journal of Internal Medicine.2020; 35(3): 641. CrossRef - Data Configuration and Publication Trends for the Korean National Health Insurance and Health Insurance Review & Assessment Database
Hae Kyung Kim, Sun Ok Song, Junghyun Noh, In-Kyung Jeong, Byung-Wan Lee Diabetes & Metabolism Journal.2020; 44(5): 671. CrossRef - Metformin and Gastrointestinal Cancer Development in Newly Diagnosed Type 2 Diabetes: A Population-Based Study in Korea
Ji Hong You, Sun Ok Song, Min Jin Kang, Yoon Young Cho, Sun Wook Kim, Sung Hwan Suh, Sujin Lee, Yong-ho Lee, Byung-Wan Lee Clinical and Translational Gastroenterology.2020; 11(11): e00254. CrossRef - Machine learning prediction for mortality of patients diagnosed with COVID-19: a nationwide Korean cohort study
Chansik An, Hyunsun Lim, Dong-Wook Kim, Jung Hyun Chang, Yoon Jung Choi, Seong Woo Kim Scientific Reports.2020;[Epub] CrossRef - The association between hospital case volume and in-hospital and one-year mortality after hip fracture surgery
Seokha Yoo, Eun Jin Jang, Junwoo Jo, Jun Gi Jo, Seungpyo Nam, Hansol Kim, Hannah Lee, Ho Geol Ryu The Bone & Joint Journal.2020; 102-B(10): 1384. CrossRef - Association between physical activity and conversion from mild cognitive impairment to dementia
Yeo Jin Kim, Kyung-Do Han, Min Seok Baek, Hanna Cho, Eun Joo Lee, Chul Hyoung Lyoo Alzheimer's Research & Therapy.2020;[Epub] CrossRef - Clinical Outcomes of COVID-19 Patients with Type 2 Diabetes: A Population-Based Study in Korea
Ji Hong You, Sang Ah Lee, Sung-Youn Chun, Sun Ok Song, Byung-Wan Lee, Dae Jung Kim, Edward J. Boyko Endocrinology and Metabolism.2020; 35(4): 901. CrossRef - Does Diabetes Increase the Risk of Contracting COVID-19? A Population-Based Study in Korea
Sung-Youn Chun, Dong Wook Kim, Sang Ah Lee, Su Jung Lee, Jung Hyun Chang, Yoon Jung Choi, Seong Woo Kim, Sun Ok Song Diabetes & Metabolism Journal.2020; 44(6): 897. CrossRef - The triglyceride glucose index is a simple and low-cost marker associated with atherosclerotic cardiovascular disease: a population-based study
Sangmo Hong, Kyungdo Han, Cheol-Young Park BMC Medicine.2020;[Epub] CrossRef - The durability and effectiveness of sensor-augmented insulin pump therapy in pediatric and young adult patients with type 1 diabetes
Yun Jeong Lee, Young Ah Lee, Jae Hyun Kim, Hye Rim Chung, Min Jeong Gu, Ji Young Kim, Choong Ho Shin Annals of Pediatric Endocrinology & Metabolism.2020; 25(4): 248. CrossRef - Impact of comorbid asthma on severity of coronavirus disease (COVID-19)
Sang Chul Lee, Kang Ju Son, Chang Hoon Han, Ji Ye Jung, Seon Cheol Park Scientific Reports.2020;[Epub] CrossRef - Big Data in Ophthalmology
Ching-Yu Cheng, Zhi Da Soh, Shivani Majithia, Sahil Thakur, Tyler Hyungtaek Rim, Yih Chung Tham, Tien Yin Wong Asia-Pacific Journal of Ophthalmology.2020; 9(4): 291. CrossRef - Maintenance of body weight is an important determinant for the risk of ischemic stroke: A nationwide population-based cohort study
Jung-Hwan Cho, Eun-Jung Rhee, Se Eun Park, Hyemi Kwon, Jin-Hyung Jung, Kyung-Do Han, Yong-Gyu Park, Soon-Jib Yoo, Yang-Hyun Kim, Won-Young Lee, Sabine Rohrmann PLOS ONE.2019; 14(1): e0210153. CrossRef - Effect of Institutional Case Volume on In-Hospital and Long-Term Mortality in Critically Ill Patients Requiring Mechanical Ventilation for 48 Hours or More
Hannah Lee, Seongmi Choi, Eun Jin Jang, Juhee Lee, Dalho Kim, Seokha Yoo, Seung Young Oh, Ho Geol Ryu Journal of Korean Medical Science.2019;[Epub] CrossRef - Impact of the 2015 Middle East Respiratory Syndrome Outbreak on Emergency Care Utilization and Mortality in South Korea
Sun Young Lee, Young-Ho Khang, Hwa-Kyung Lim Yonsei Medical Journal.2019; 60(8): 796. CrossRef - Effect of Institutional Case Volume on In-hospital Mortality After Living Donor Liver Transplantation: Analysis of 7073 Cases Between 2007 and 2016 in Korea
Seokha Yoo, Eun Jin Jang, Nam-Joon Yi, Ga Hee Kim, Dal Ho Kim, Hannah Lee, Chul-Woo Jung, Ho Geol Ryu Transplantation.2019; 103(5): 952. CrossRef - Increased risk of benign paroxysmal positional vertigo in osteoporosis: a nationwide population-based cohort study
Hayoung Byun, Jae Ho Chung, Seung Hwan Lee, Chul Won Park, Eun Mi Kim, Inah Kim Scientific Reports.2019;[Epub] CrossRef - Incremental economic burden associated with exudative age-related macular degeneration: a population-based study
Siin Kim, Sang Jun Park, Seong Jun Byun, Kyu Hyung Park, Hae Sun Suh BMC Health Services Research.2019;[Epub] CrossRef - Patients with Inflammatory Bowel Disease Are at an Increased Risk of Parkinson’s Disease: A South Korean Nationwide Population-Based Study
Seona Park, Jihye Kim, Jaeyoung Chun, Kyungdo Han, Hosim Soh, Eun Ae Kang, Hyun Jung Lee, Jong Pil Im, Joo Sung Kim Journal of Clinical Medicine.2019; 8(8): 1191. CrossRef - Effect of hypertension duration and blood pressure level on ischaemic stroke risk in atrial fibrillation: nationwide data covering the entire Korean population
Tae-Hoon Kim, Pil-Sung Yang, Hee Tae Yu, Eunsun Jang, Hyejung Shin, Ha Yan Kim, Jae-Sun Uhm, Jong-Youn Kim, Jung-Hoon Sung, Hui-Nam Pak, Moon-Hyoung Lee, Boyoung Joung, Gregory Y H Lip European Heart Journal.2019; 40(10): 809. CrossRef - Perioperative red blood cell transfusion and mortality following heart transplantation: A retrospective nationwide population‐based study between 2007 and 2016 in Korea
Karam Nam, Eun Jin Jang, Ga Hee Kim, Hyung Been Yhim, Hannah Lee, Dal Ho Kim, Ho Geol Ryu Journal of Cardiac Surgery.2019; 34(10): 927. CrossRef - The Effect of Health-Related Behaviors on Disease Progression and Mortality in Early Stages of Chronic Kidney Disease: A Korean Nationwide Population-Based Study
Yookyung Lee, SuYeon Kwon, Jong Joo Moon, Kyungdo Han, Nam-Jong Paik, Won-Seok Kim Journal of Clinical Medicine.2019; 8(8): 1100. CrossRef - Association of body mass index with bladder cancer risk in men depends on abdominal obesity
Jin Bong Choi, Jung Ho Kim, Sung-Hoo Hong, Kyung-Do Han, U-Syn Ha World Journal of Urology.2019; 37(11): 2393. CrossRef - Time‐ and Dose‐Dependent Association of Statin Use With Risk of Clinically Relevant New‐Onset Diabetes Mellitus in Primary Prevention: A Nationwide Observational Cohort Study
Min Jung Ko, Ae Jeong Jo, Yun Jung Kim, Shin Hee Kang, Songhee Cho, Sang‐Ho Jo, Cheol‐Young Park, Sung‐Cheol Yun, Woo Je Lee, Duk‐Woo Park Journal of the American Heart Association.2019;[Epub] CrossRef - Association of Long-term Use of Low-Dose Aspirin as Chemoprevention With Risk of Lung Cancer
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J.-S. Yun, Y.-M. Park, K. Han, S.-A. Cha, Y.-B. Ahn, S.-H. Ko Diabetes & Metabolism.2019; 45(1): 19. CrossRef - Risk of Incident Dementia According to Metabolic Health and Obesity Status in Late Life: A Population-Based Cohort Study
Ji-Yeon Lee, Kyungdo Han, Eugene Han, Gyuri Kim, Hanna Cho, Kwang Joon Kim, Byung Wan Lee, Eun Seok Kang, Bong-Soo Cha, Carol Brayne, Yong-ho Lee The Journal of Clinical Endocrinology & Metabolism.2019; 104(7): 2942. CrossRef - Increased Risk of Osteoporotic Fracture in Postgastrectomy Gastric Cancer Survivors Compared With Matched Controls: A Nationwide Cohort Study in Korea
Dong Wook Shin, Beomseok Suh, Hyunsun Lim, Yun-Suhk Suh, Yoon Jin Choi, Su-Min Jeong, Jae Moon Yun, Sun Ok Song, Youngmin Park American Journal of Gastroenterology.2019; 114(11): 1735. CrossRef - Metabolic syndrome is associated with an increased risk of psoriasis: A nationwide population-based study
Ha-Na Kim, Kyungdo Han, Yong-Gyu Park, Ji Hyun Lee Metabolism.2019; 99: 19. CrossRef - Association of Exposure to Diagnostic Low-Dose Ionizing Radiation With Risk of Cancer Among Youths in South Korea
Jae-Young Hong, Kyungdo Han, Jin-Hyung Jung, Jung Sun Kim JAMA Network Open.2019; 2(9): e1910584. CrossRef - Long‐term clinical outcomes in patients with autoimmune hepatitis according to treatment response in Asian country
Jonggi Choi, Gwang Hyeon Choi, Danbi Lee, Ju Hyun Shim, Young‐Suk Lim, Han Chu Lee, Young‐Hwa Chung, Yung‐Sang Lee, Kang Mo Kim Liver International.2019; 39(5): 985. CrossRef - Effectiveness and Safety of Direct Oral Anticoagulant for Secondary Prevention in Asians with Atrial Fibrillation
Jiesuck Park, So-Ryoung Lee, Eue-Keun Choi, Soonil Kwon, Jin-Hyung Jung, Kyung-Do Han, Myung-Jin Cha, Sang-Bae Ko, Seil Oh, Gregory Y. H. Lip Journal of Clinical Medicine.2019; 8(12): 2228. CrossRef - Optimal Rivaroxaban Dose in Asian Patients With Atrial Fibrillation and Normal or Mildly Impaired Renal Function
So-Ryoung Lee, Eue-Keun Choi, Kyung-Do Han, Jin-Hyung Jung, Seil Oh, Gregory Y.H. Lip Stroke.2019; 50(5): 1140. CrossRef - Tobacco Smoking and Alcohol Consumption Are Related to Benign Parotid Tumor: A Nested Case-Control Study Using a National Health Screening Cohort
So Young Kim, Chanyang Min, Dong Jun Oh, Hyo Geun Choi Clinical and Experimental Otorhinolaryngology.2019; 12(4): 412. CrossRef - Increased Risk of Diabetes in Inflammatory Bowel Disease Patients: A Nationwide Population-Based Study in Korea
Eun Ae Kang, Kyungdo Han, Jaeyoung Chun, Hosim Soh, Seona Park, Jong Pil Im, Joo Sung Kim Journal of Clinical Medicine.2019; 8(3): 343. CrossRef - Changes in the Diagnostic Efficiency of Thyroid Fine-Needle Aspiration Biopsy during the Era of Increased Thyroid Cancer Screening in Korea
Young Ki Lee, Kyeong Hye Park, Young Duk Song, Taemi Youk, Joo Young Nam, Sun Ok Song, Dong Yeob Shin, Eun Jig Lee Cancer Research and Treatment.2019; 51(4): 1430. CrossRef -
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12
Inhibitors in an East Asian Population With Acute Coronary Syndrome: A Nationwide Population‐Based Cohort Study
Ji Eun Yun, Yun Jung Kim, Ji Jeong Park, Sehee Kim, Keunhui Park, Min Soo Cho, Gi‐Byoung Nam, Duk‐Woo Park Journal of the American Heart Association.2019;[Epub] CrossRef - Direct Oral Anticoagulants in Patients With Nonvalvular Atrial Fibrillation and Low Body Weight
So-Ryoung Lee, Eue-Keun Choi, Chan Soon Park, Kyung-Do Han, Jin-Hyung Jung, Seil Oh, Gregory Y.H. Lip Journal of the American College of Cardiology.2019; 73(8): 919. CrossRef - Trends in varicella and herpes zoster epidemiology before and after the implementation of universal one-dose varicella vaccination over one decade in South Korea, 2003–2015
Jae-Ki Choi, Sun Hee Park, Sanghyun Park, Su-Mi Choi, Si-Hyun Kim, Dong-Gun Lee, Jin-Hong Yoo, Jung-Hyun Choi, Jin Han Kang Human Vaccines & Immunotherapeutics.2019; 15(11): 2554. CrossRef - Obesity Fact Sheet in Korea, 2018: Data Focusing on Waist Circumference and Obesity-Related Comorbidities
Ga Eun Nam, Yang-Hyun Kim, Kyungdo Han, Jin-Hyung Jung, Yong Gyu Park, Kwan-Woo Lee, Eun-Jung Rhee, Jang Won Son, Seong-Su Lee, Hyuk-Sang Kwon, Won-Young Lee, Soon Jib Yoo Journal of Obesity & Metabolic Syndrome.2019; 28(4): 236. CrossRef - Long-Term Impact of Newly Diagnosed Atrial Fibrillation During Critical Care
Kyu Kim, Pil-Sung Yang, Eunsun Jang, Hee Tae Yu, Tae-Hoon Kim, Jae-Sun Uhm, Jong-Youn Kim, Jung-Hoon Sung, Hui-Nam Pak, Moon-Hyoung Lee, Gregory Y.H. Lip, Boyoung Joung Chest.2019; 156(3): 518. CrossRef - Correlation of Androgen Deprivation Therapy with Cognitive Dysfunction in Patients with Prostate Cancer: A Nationwide Population-Based Study Using the National Health Insurance Service Database
Bum Sik Tae, Byung Jo Jeon, Seung Hun Shin, Hoon Choi, Jae Hyun Bae, Jae Young Park Cancer Research and Treatment.2019; 51(2): 593. CrossRef - Non-Vitamin K Antagonist Oral Anticoagulants in Patients with Atrial Fibrillation and Valvular Heart Disease
Inki Moon, So-Ryoung Lee, Eue-Keun Choi, Euijae Lee, Jin-Hyung Jung, Kyung-Do Han, Myung-Jin Cha, Seil Oh, Gregory Y.H. Lip Journal of Clinical Medicine.2019; 8(10): 1624. CrossRef - Relation between Baseline Height and New Diabetes Development: A Nationwide Population-Based Study
Eun-Jung Rhee, Jung-Hwan Cho, Hyemi Kwon, Se-Eun Park, Jin-Hyung Jung, Kyung-Do Han, Yong-Gyu Park, Yang-Hyun Kim, Won-Young Lee Diabetes & Metabolism Journal.2019; 43(6): 794. CrossRef - The Risk of Myocardial Infarction and Ischemic Stroke According to Waist Circumference in 21,749,261 Korean Adults: A Nationwide Population-Based Study
Jung-Hwan Cho, Eun-Jung Rhee, Se-Eun Park, Hyemi Kwon, Jin-Hyung Jung, Kyung-Do Han, Yong-Gyu Park, Hye Soon Park, Yang-Hyun Kim, Soon-Jib Yoo, Won-Young Lee Diabetes & Metabolism Journal.2019; 43(2): 206. CrossRef - The risk of end-stage renal disease in systemic lupus erythematosus
Hong Sang Choi, Kyung-Do Han, Jin-Hyung Jung, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Soo Wan Kim Medicine.2019; 98(28): e16420. CrossRef - Antithrombotic Therapy in Patients With Atrial Fibrillation After Percutaneous Coronary Intervention During 2-Year Follow-Up, from a Nationwide Population Study
Jiesuck Park, Eue-Keun Choi, Kyung-Do Han, You-Jung Choi, So-Ryoung Lee, Myung-Jin Cha, Jeehoon Kang, Kyung Woo Park, Seil Oh, Gregory Y.H. Lip The American Journal of Cardiology.2019; 123(12): 1921. CrossRef - Outcomes After Use of Standard- and Low-Dose Non–Vitamin K Oral Anticoagulants in Asian Patients With Atrial Fibrillation
Min Soo Cho, Ji Eun Yun, Ji Jeong Park, Yun Jung Kim, Jessie Lee, Hyungmin Kim, Duk-Woo Park, Gi-Byoung Nam Stroke.2019; 50(1): 110. CrossRef - Association between Atrial Fibrillation, Myocardial Infarction, Heart Failure and Mortality in Patients with Nontuberculous Mycobacterial Infection: a nationwide population-based study
Chan Soon Park, Eue-Keun Choi, Bongseong Kim, Kyung-Do Han, So-Ryoung Lee, Myung-Jin Cha, Seil Oh Scientific Reports.2019;[Epub] CrossRef - National practice patterns and direct medical costs for prostate cancer in Korea across a 10 year period: a nationwide population-based study using a national health insurance database
Ho Won Kang, Seok-Joong Yun, Jae Il Chung, Hoon Choi, Jae Heon Kim, Ho Song Yu, Yun-Sok Ha, In-Chang Cho, Hyung Joon Kim, Hyun Chul Chung, Jun Sung Koh, Wun-Jae Kim, Jong-Hyock Park, Ji Youl Lee, So-Young Kim BMC Health Services Research.2019;[Epub] CrossRef - Institutional Case-Volume and Mortality After Heart Transplantation
Karam Nam, Eun Jin Jang, Ga Hee Kim, Hannah Lee, Dal Ho Kim, Ho Geol Ryu International Heart Journal.2019; 60(3): 695. CrossRef - Weight change is significantly associated with risk of thyroid cancer: A nationwide population-based cohort study
Hyemi Kwon, Kyung-Do Han, Cheol-Young Park Scientific Reports.2019;[Epub] CrossRef - Venous thromboembolism in relapsed or refractory multiple myeloma patients treated with lenalidomide plus dexamethasone
Junghoon Shin, Je-Jung Lee, Kihyun Kim, Chang-Ki Min, Jeong-Ok Lee, Cheolwon Suh, Jin Seok Kim, Yoo Jin Lee, Sung-Soo Yoon, Jae-Cheol Jo, Ho Sup Lee, Soo-Mee Bang International Journal of Hematology.2019; 109(1): 79. CrossRef - Actinic keratosis and diabetes complications: A nationwide population-based study in South Korea (2009–2015)
YoungBok Lee, JiHyun Lee, JinYoung Choi, DongSoo Yu, KyungDo Han, Yong-Gyu Park Diabetes & Metabolism.2019; 45(1): 32. CrossRef - Ankylosing spondylitis: A novel risk factor for atrial fibrillation — A nationwide population-based study
Inki Moon, Eue-Keun Choi, Jin-Hyung Jung, Kyung-Do Han, You-Jung Choi, Jiesuck Park, Jun Hwan Cho, Euijae Lee, Wonseok Choe, So-Ryoung Lee, Myung-Jin Cha, Woo-Hyun Lim, Seil Oh International Journal of Cardiology.2019; 275: 77. CrossRef - Cancer risk among young men with weight gain after smoking cessation: A population-based cohort study
Kyuwoong Kim, Seulggie Choi, Gyeongsil Lee, Su-Min Jeong, Sung Min Kim, Joung Sik Son, Jae-Moon Yun, Yeon-Yong Kim, Seong Yong Park, Sang Min Park Cancer Epidemiology.2019; 60: 86. CrossRef - Effect of drug compliance on health care costs in newly-diagnosed dementia: Analysis of nationwide population-based data
Seung-Taek Oh, Kyu-Tae Han, Won-Jung Choi, Jaesub Park Journal of Psychiatric Research.2019; 118: 31. CrossRef - Colorectal Cancer Risks According to Sex Differences in Patients With Type II Diabetes Mellitus: A Korean Nationwide Population-Based Cohort Study
Ji Min Lee, Kang-Moon Lee, Dae Bum Kim, Seung-Hyun Ko, Yong Gyu Park Clinical and Translational Gastroenterology.2019; 10(10): e00090. CrossRef - Body Mass Index Variability and Long-term Risk of New-Onset Atrial Fibrillation in the General Population: A Korean Nationwide Cohort Study
Yeong-Min Lim, Pil-Sung Yang, Eunsun Jang, Hee Tae Yu, Tae-Hoon Kim, Jae-Sun Uhm, Jong-Youn Kim, Hui-Nam Pak, Moon-Hyoung Lee, Boyoung Joung, Gregory Y.H. Lip Mayo Clinic Proceedings.2019; 94(2): 225. CrossRef - Childbirth in young Korean women with previously treated breast cancer: The SMARTSHIP study
Hak Min Lee, Bo Wook Kim, Seho Park, Sungmin Park, Jeon Eon Lee, Young Jin Choi, Sung Yong Kim, Sang Uk Woo, Hyun Jo Youn, Ilkyun Lee Breast Cancer Research and Treatment.2019; 176(2): 419. CrossRef - Obstructive sleep apnea as a risk factor for incident end stage renal disease: a nationwide population-based cohort study from Korea
Hong Sang Choi, Ha Yeon Kim, Kyung-Do Han, Jin-Hyung Jung, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Soo Wan Kim Clinical and Experimental Nephrology.2019; 23(12): 1391. CrossRef - Severe hypoglycemia and the risk of cardiovascular disease and mortality in type 2 diabetes: a nationwide population-based cohort study
Jae-Seung Yun, Yong-Moon Park, Kyungdo Han, Seon-Ah Cha, Yu-Bae Ahn, Seung-Hyun Ko Cardiovascular Diabetology.2019;[Epub] CrossRef - Severity of dental caries and risk of coronary heart disease in middle-aged men and women: a population-based cohort study of Korean adults, 2002–2013
Kyuwoong Kim, Seulggie Choi, Jooyoung Chang, Sung Min Kim, Seon Jip Kim, Ryan Jin-Young Kim, Hyun-Jae Cho, Sang Min Park Scientific Reports.2019;[Epub] CrossRef - Risk of Anxiety and Depression in Patients with Inflammatory Bowel Disease: A Nationwide, Population-Based Study
Kookhwan Choi, Jaeyoung Chun, Kyungdo Han, Seona Park, Hosim Soh, Jihye Kim, Jooyoung Lee, Hyun Lee, Jong Im, Joo Kim Journal of Clinical Medicine.2019; 8(5): 654. CrossRef - The Effects after Implementing a Drug Utilization Review System on Contraindicated Drug use: A Systematic Review
Heeyoung Lee, Hyea Suk Choi, Eunhee Ji Korean Journal of Clinical Pharmacy.2019; 29(1): 9. CrossRef - Nationwide Trends in Pancreatitis and Pancreatic Cancer Risk Among Patients With Newly Diagnosed Type 2 Diabetes Receiving Dipeptidyl Peptidase 4 Inhibitors
Minyoung Lee, Jiyu Sun, Minkyung Han, Yongin Cho, Ji-Yeon Lee, Chung Mo Nam, Eun Seok Kang Diabetes Care.2019; 42(11): 2057. CrossRef - Dose–response relationship between cigarette smoking and risk of ulcerative colitis: a nationwide population-based study
Seona Park, Jaeyoung Chun, Kyung-Do Han, Hosim Soh, Eun Ae Kang, Hyun Jung Lee, Jong Pil Im, Joo Sung Kim Journal of Gastroenterology.2019; 54(10): 881. CrossRef - Is androgen deprivation therapy associated with cerebral infarction in patients with prostate cancer? A Korean nationwide population‐based propensity score matching study
Bum Sik Tae, Byeong Jo Jeon, Hoon Choi, Jae Hyun Bae, Jae Young Park Cancer Medicine.2019; 8(9): 4475. CrossRef - Adult lung transplantation case-volume and in-hospital and long-term mortality in Korea
Susie Yoon, Eun Jin Jang, Ga Hee Kim, Dal Ho Kim, Tae-Yoon Lim, Hannah Lee, Ho Geol Ryu Journal of Cardiothoracic Surgery.2019;[Epub] CrossRef - Systemic lupus erythematosus is a risk factor for cancer: a nationwide population-based study in Korea
E.H. Bae, S.Y. Lim, K.-D. Han, J.-Hy. Jung, H.S. Choi, C.S. Kim, S.K. Ma, SW Kim Lupus.2019; 28(3): 317. CrossRef - Association Between Drug Exposure and Occurrence of Parkinsonism in Korea: A Population-Based Case-Control Study
Siin Kim, Sang-Myung Cheon, Hae Sun Suh Annals of Pharmacotherapy.2019; 53(11): 1102. CrossRef - Validation of diagnostic codes of major clinical outcomes in a National Health Insurance database
Jiesuck Park, Soonil Kwon, Eue-Keun Choi, You-jung Choi, Euijae Lee, Wonseok Choe, So-Ryoung Lee, Myung-Jin Cha, Woo-Hyun Lim, Seil Oh International Journal of Arrhythmia.2019;[Epub] CrossRef - HDL-Cholesterol, Its Variability, and the Risk of Diabetes: A Nationwide Population-Based Study
Seung-Hwan Lee, Hun-Sung Kim, Yong-Moon Park, Hyuk-Sang Kwon, Kun-Ho Yoon, Kyungdo Han, Mee Kyoung Kim The Journal of Clinical Endocrinology & Metabolism.2019; 104(11): 5633. CrossRef - Prognostic influence of Korean public medical insurance system on breast cancer patients
Ki-Tae Hwang, Young Wook Ju, Young A Kim, Jongjin Kim, Sohee Oh, Jiwoong Jung, Young Jun Chai, In Sil Choi, So Won Oh Annals of Surgical Treatment and Research.2019; 96(2): 58. CrossRef - Effect of Case Volume on Mortality After Pediatric Liver Transplantation in Korea
Hannah Lee, Eun Jin Jang, Ga Hee Kim, Nam Joon Yi, Dal Ho Kim, Seokha Yoo, Hyung Sang Row, Chul-Woo Jung, Seung-Young Oh, Ho Geol Ryu Transplantation.2019; 103(8): 1649. CrossRef - Prescription Patterns and Burden of Pediatric Asthma in Korea
In Suk Sol, Yoon Hee Kim, Soo Yeon Kim, Sun Ha Choi, Jong Deok Kim, Bo Ok Kim, Ji Eun Moon, Kyung Won Kim, Myung Hyun Sohn Allergy, Asthma & Immunology Research.2019; 11(2): 280. CrossRef - Increased risk of coronary heart disease and stroke in lung cancer survivors: A Korean nationwide study of 20,458 patients
Dong Woog Yoon, Dong Wook Shin, Jong Ho Cho, Jeong Hoon Yang, Su-Min Jeong, Kyungdo Han, Sang Hyun Park Lung Cancer.2019; 136: 115. CrossRef - Waist Circumference and All-Cause Mortality Independent of Body Mass Index in Korean Population from the National Health Insurance Health Checkup 2009–2015
Yang-Hyun Kim, Seon Mee Kim, Kyung-Do Han, Jin-Hyung Jung, Seong-Su Lee, Sang Woo Oh, Hye Soon Park, Eun-Jung Rhee, Won-Young Lee, Soon Jib Yoo Journal of Clinical Medicine.2019; 8(1): 72. CrossRef - Temporal trends in prevalence and antithrombotic treatment among Asians with atrial fibrillation undergoing percutaneous coronary intervention: A nationwide Korean population-based study
Jiesuck Park, Eue-Keun Choi, Kyung-Do Han, You-jung Choi, Euijae Lee, Wonseok Choe, So-Ryoung Lee, Myung-Jin Cha, Woo-Hyun Lim, Jeehoon Kang, Kyung Woo Park, Seil Oh, Gregory Y. H. Lip, Chiara Lazzeri PLOS ONE.2019; 14(1): e0209593. CrossRef - Factors influencing the incidence and treatment of intracranial aneurysm and subarachnoid hemorrhage: time trends and socioeconomic disparities under an universal healthcare system
Won Kyung Lee, Chang Wan Oh, Heeyoung Lee, Kun Sei Lee, Hyeonseon Park Journal of NeuroInterventional Surgery.2019; 11(2): 159. CrossRef - Increasing trends in hospital care burden of atrial fibrillation in Korea, 2006 through 2015
Daehoon Kim, Pil-Sung Yang, Eunsun Jang, Hee Tae Yu, Tae-Hoon Kim, Jae-Sun Uhm, Jong Youn Kim, Hui-Nam Pak, Moon-Hyoung Lee, Boyoung Joung, Gregory Y H Lip Heart.2018; 104(24): 2010. CrossRef - Appropriate Amount of Regular Exercise Is Associated with a Reduced Mortality Risk
DA YOUNG LEE, EUN-JUNG RHEE, JUNG HWAN CHO, HYEMI KWON, SE EUN PARK, YANG-HYUN KIM, KYUNGDO HAN, YONG-KYU PARK, SOON JIB YOO, WON-YOUNG LEE Medicine & Science in Sports & Exercise.2018; 50(12): 2451. CrossRef - The effect of continuity of care on the incidence of end-stage renal disease in patients with newly detected type 2 diabetic nephropathy: a retrospective cohort study
Yun Jung Jang, Yoon Soo Choy, Chung Mo Nam, Ki Tae Moon, Eun-Cheol Park BMC Nephrology.2018;[Epub] CrossRef - Increased end-stage renal disease risk in patients with inflammatory bowel disease: A nationwide population-based study
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- Factors Associated for Mild Cognitive Impairment in Older Korean Adults with Type 2 Diabetes Mellitus
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Yun Jeong Lee, Hye Mi Kang, Na Kyung Kim, Ju Yeon Yang, Jung Hyun Noh, Kyung Soo Ko, Byoung Doo Rhee, Dong-Jun Kim
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Diabetes Metab J. 2014;38(2):150-157. Published online April 18, 2014
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DOI: https://doi.org/10.4093/dmj.2014.38.2.150
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Abstract
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- Background
The aim of this study was to identify factors associated with mild cognitive impairment (MCI) in older Korean adults with type 2 diabetes mellitus. MethodsA total of 226 older (age ≥65 years) adults without a history of cerebrovascular disease or dementia participated in this study. Cognitive function was assessed with the Montreal Cognitive Assessment-Korean version (MoCA-K). A MoCA-K score <23 was defined as MCI. ResultsThe prevalence of MCI was 32.7%. In a logistic regression analysis, age (≥74 years old vs. 65-68 years old; odds ratio [OR], 3.69; 95% confidence interval [CI], 1.55 to 8.82; P=0.003), educational background (college graduation vs. no school or elementary school graduation; OR, 0.16; 95% CI, 0.05 to 0.46; P=0.001), and systolic blood pressure (≥135 mm Hg vs. ≤120 mm Hg; OR, 3.25; 95% CI, 1.29 to 8.17; P=0.012) were associated with MCI. ConclusionMore concentrated efforts focused on early detection and appropriate management of MCI may be required in older Korean adults with type 2 diabetes mellitus.
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Citations
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Insa Feinkohl, Markéta Keller, Christine M. Robertson, Joanne R. Morling, Stela McLachlan, Brian M. Frier, Ian J. Deary, Mark W. J. Strachan, Jackie F. Price Diabetologia.2015; 58(7): 1637. CrossRef - Association between obesity and depression in patients with diabetes mellitus type 2; a study protocol
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- Current Status of Diabetic Peripheral Neuropathy in Korea: Report of a Hospital-Based Study of Type 2 Diabetic Patients in Korea by the Diabetic Neuropathy Study Group of the Korean Diabetes Association
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Jong Chul Won, Sang Soo Kim, Kyung Soo Ko, Bong-Yun Cha
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Diabetes Metab J. 2014;38(1):25-31. Published online February 19, 2014
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DOI: https://doi.org/10.4093/dmj.2014.38.1.25
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Abstract
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Diabetic peripheral neuropathy (DPN) is the most common complication associated with diabetes. DPN can present as a loss of sensation, may lead to neuropathic ulcers, and is a leading cause of amputation. Reported estimates of the prevalence of DPN vary due to differences in study populations and diagnostic criteria. Furthermore, the epidemiology and clinical characteristics of DPN in Korean patients with type 2 diabetes mellitus (T2DM) are not as well understood as those of other complications of diabetes such as retinal and renal disease. Recently, the Diabetic Neuropathy Study Group of the Korean Diabetes Association (KDA) conducted a study investigating the impact of DPN on disease burden and quality of life in patients with T2DM and has published some data that are representative of the nation. This review investigated the prevalence and associated clinical implications of DPN in Korean patients with diabetes based on the KDA study.
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Stefan Kopf, Jan B. Groener, Zoltan Kender, Thomas Fleming, Sandra Bischoff, Johann Jende, Carsten Schumann, Stefan Ries, Martin Bendszus, Sigrid Schuh-Hofer, Rolf-Detlef Treede, Peter P. Nawroth Diabetes Research and Clinical Practice.2018; 146: 191. CrossRef - Role of neopterin as a biochemical marker for peripheral neuropathy in pediatric patients with type 1 diabetes: Relation to nerve conduction studies
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- Efficacy and Safety of Biphasic Insulin Aspart 30/70 in Type 2 Diabetes Suboptimally Controlled on Oral Antidiabetic Therapy in Korea: A Multicenter, Open-Label, Single-Arm Study
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Kee-Ho Song, Jung Min Kim, Jung-Hyun Noh, Yongsoo Park, Hyun-Shik Son, Kyong Wan Min, Kyung Soo Ko
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Diabetes Metab J. 2013;37(2):117-124. Published online April 16, 2013
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DOI: https://doi.org/10.4093/dmj.2013.37.2.117
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Abstract
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- Background
The purpose of this study was to evaluate change in glycosylated hemoglobin (HbA1c), side effects, and quality of life (QOL) after a 16-week treatment period with Biphasic insulin aspart 30/70 (BIasp30) in patients with type 2 diabetes mellitus (T2DM) who had been suboptimally controlled with oral antidiabetic drugs (OADs). MethodsThe study consisted of a 4-week titration period when concurrent OAD(s) were replaced with BIasp30 and followed by a 12-week maintenance period. All patients completed the Diabetes Treatment Satisfaction Questionnaire at the beginning and the end of the trial. Hypoglycemic episodes were recorded by the patient throughout the trial. ResultsSixty patients were included, of whom 55 patients (92%) completed the full 16-week treatment period. Seven-point blood glucose was significantly improved as compared with the baseline, except for the postlunch blood glucose level. HbA1c at the end of period was significantly improved from 9.2% to 8.2% (P<0.001). Eleven percent (n=6) of patients achieved HbA1c values ≤6.5% and 22% (n=12) of patients achieved <7.0%. There were 3.4 episodes/patients-year of minor hypoglycemia and 0.05 episodes/patients-year of major hypoglycemia. QOL showed significant changes only in the acceptability of high blood glucose category (P=0.003). ConclusionTreatment with once or twice daily BIasp30 may be an option for the patients with T2DM suboptimally controlled with OADs in Korea. However, considering the low number of patients achieving the HbA1c target and the high postlunch blood glucose levels, additional management with another modality may be required for optimal control.
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- 15 Years of Experience with Biphasic Insulin Aspart 30 in Type 2 Diabetes
Andreas Liebl, Viswanathan Mohan, Wenying Yang, Krzysztof Strojek, Sultan Linjawi Drugs in R&D.2018; 18(1): 27. CrossRef - Basal‐prandial versus premixed insulin in patients with type 2 diabetes requiring insulin intensification after basal insulin optimization: A 24‐week randomized non‐inferiority trial
Sang‐Man Jin, Jae Hyeon Kim, Kyung Wan Min, Ji Hyun Lee, Kue Jeong Ahn, Jeong Hyun Park, Hak Chul Jang, Seok Won Park, Kwan Woo Lee, Kyu Chang Won, Young‐Il Kim, Choon Hee Chung, Tae Sun Park, Jee‐Hyun Lee, Moon‐Kyu Lee Journal of Diabetes.2016; 8(3): 405. CrossRef - The optimal morning:evening ratio in total dose of twice‐daily biphasic insulin analogue in poorly controlled Type 2 diabetes: a 24‐week multi‐centre prospective, randomized controlled, open‐labelled clinical study
C. H. Jung, J.‐Y. Park, J. H. Cho, K.‐H. Yoon, H. K. Yang, Y.‐H. Lee, B. S. Cha, B.‐W. Lee Diabetic Medicine.2014; 31(1): 68. CrossRef - Response: Efficacy and Safety of Biphasic Insulin Aspart 30/70 in Type 2 Diabetes Suboptimally Controlled on Oral Antidiabetic Therapy in Korea: A Multicenter, Open-Label, Single-Arm Study (Diabetes Metab J2013;37:117-24)
Kee-Ho Song, Jung Min Kim, Jung-Hyun Noh, Yongsoo Park, Hyun-Shik Son, Kyong Wan Min, Kyung Soo Ko Diabetes & Metabolism Journal.2013; 37(3): 214. CrossRef - Letter: Efficacy and Safety of Biphasic Insulin Aspart 30/70 in Type 2 Diabetes Suboptimally Controlled on Oral Antidiabetic Therapy in Korea: A Multicenter, Open-Label, Single-Arm Study (Diabetes Metab J2013;37:117-24)
Byung-Wan Lee Diabetes & Metabolism Journal.2013; 37(3): 212. CrossRef
- The Effects of Glyburide on Apoptosis and Endoplasmic Reticulum Stress in INS-1 Cells in a Glucolipotoxic Condition
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Min Jeong Kwon, Hye Suk Chung, Chang Shin Yoon, Jung Hae Ko, Hae Jung Jun, Tae Kyun Kim, Soon Hee Lee, Kyung Soo Ko, Byoung Doo Rhee, Mi Kyung Kim, Jeong Hyun Park
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Diabetes Metab J. 2011;35(5):480-488. Published online October 31, 2011
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DOI: https://doi.org/10.4093/dmj.2011.35.5.480
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4,486
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Abstract
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- Background
β-cell death due to endoplasmic reticulum (ER) stress has been regarded as an important pathogenic component of type 2 diabetes. The possibility has been suggested that sulfonylurea, currently being used as one of the main oral hypoglycemic agents of type 2 diabetes, increases ER stress, which could lead to sulfonylurea failure. The authors of the present study examined ER stress of β-cells in a glucolipotoxic condition using glyburide (GB) in an environment mimicking type 2 diabetes. MethodsApoptosis was induced by adding various concentrations of GB (0.001 to 200 µM) to a glucolipotoxic condition using 33 mM glucose, and the effects of varied concentrations of palmitate were evaluated via annexin V staining. The markers of ER stress and pro-apoptotic markers were assessed by Western blotting and semi-quantitative reverse transcription-polymerase chain reaction. Additionally, the anti-apoptotic markers were evaluated. ResultsAddition of any concentration of GB in 150 µM palmitate and 33 mM glucose did not increase apoptosis. The expression of phosphorylated eukaryotic initiation factor (eIF-2α) was increased and cleaved caspase 3 was decreased by adding GB to a glucolipotoxic condition. However, other ER stress-associated markers such as Bip-1, X-box binding protein-1, ATF-4 and C/EBP-homologous protein transcription factor and anti-apoptotic markers phosphor-p85 phosphatidylinositol 3-kinase and phosphorylation of Akt did not change significantly. ConclusionGB did not show further deleterious effects on the degree of apoptosis or ER stress of INS-1 cells in a glucolipotoxic condition. Increased phosphorylation of eIF-2α may attenuate ER stress for adaptation to increased ER protein load.
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- The antagonistic atorvastatin-glibenclamide interactions suppressed the atorvastatin-induced Bax/cytochrome c/p53 mRNA expressions and increased Rho A mRNA expression in B16f10 melanoma cell culture
Maryam Malek, Nasim Dana, Ahmad Ghasemi, Maedeh Ghasemi Gene Reports.2021; 23: 101156. CrossRef - Expression profiles of stress-related genes in islets from donors with progressively impaired glucose metabolism
Marcus Lundberg, Anton Stenwall, Angie Tegehall, Olle Korsgren, Oskar Skog Islets.2018; 10(2): 69. CrossRef - Pharmacological Modulators of Endoplasmic Reticulum Stress in Metabolic Diseases
Tae Jung, Kyung Choi International Journal of Molecular Sciences.2016; 17(2): 192. CrossRef - The TRPA1 channel and oral hypoglycemic agents
Carlos Manlio Diaz-Garcia Channels.2013; 7(6): 420. CrossRef - Dimethyl sulfoxide reduces hepatocellular lipid accumulation through autophagy induction
Young Mi Song, Sun-Ok Song, Yong-Keun Jung, Eun-Seok Kang, Bong Soo Cha, Hyun Chul Lee, Byung-Wan Lee Autophagy.2012; 8(7): 1085. CrossRef - The Duration of Sulfonylurea Treatment Is Associated withβ-Cell Dysfunction in Patients with Type 2 Diabetes Mellitus
Mi-Seon Shin, Jee Hee Yu, Chang Hee Jung, Jenie Yoonoo Hwang, Woo Je Lee, Min-Seon Kim, Joong-Yeol Park Diabetes Technology & Therapeutics.2012; 14(11): 1033. CrossRef
- Polymorphisms of the Reg1α Gene and Early Onset Type 2 Diabetes in the Korean Population
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Bo Kyung Koo, Young Min Cho, Kuchan Kimm, Jong-Young Lee, Bermseok Oh, Byung Lae Park, Hyun Sub Cheong, Hyoung Doo Shin, Kyung Soo Ko, Sang Gyu Park, Hong Kyu Lee, Kyong Soo Park
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Korean Diabetes J. 2010;34(4):229-236. Published online August 31, 2010
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DOI: https://doi.org/10.4093/kdj.2010.34.4.229
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Abstract
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- Background
The Reg gene has been reported to be expressed in regenerating islets and Reg1 protein to be up-regulated at an early stage of diabetes in mice. As human Reg1α is homologous with murine Reg1, we investigated whether common variants in Reg1α are associated with type 2 diabetes in the Korean population. MethodsWe sequenced the Reg1α gene to identify common polymorphisms using 24 Korean DNA samples. Of 11 polymorphisms found, five common ones (g.-385T>C [rs10165462], g.-36T>G [rs25689789], g.209G>T [rs2070707], g.1385C>G [novel], and g.2199G>A [novel]) were genotyped in 752 type 2 diabetic patients and 642 non-diabetic subjects. ResultsNo polymorphism was associated with the risk of type 2 diabetes. However, g.-385C and g.2199A lowered the risk of early-onset type 2 diabetes, defined as a diagnosis in subjects whose age at diagnosis was 25 years or more but less than 40 years (odds ratio [OR], 0.721 [0.535 to 0.971] and 0.731 [0.546 to 0.977] for g.-385C and g.2199A, respectively) and g.1385G increased the risk of early-onset diabetes (OR, 1.398 [1.055 to 1.854]). Although adjusting for errors in multiple hypotheses-testing showed no statistically significant association between the three individual polymorphisms and early-onset diabetes, the haplotype H1, composed of g.-385C, g.1385C, and g.2199A, was associated with a reduced risk of early-onset diabetes (OR, 0.590 [0.396 to 0.877], P = 0.009). ConclusionPolymorphisms in the Reg1α were not found to be associated with overall susceptibility to type 2 diabetes, though some showed modest associations with early-onset type 2 diabetes in the Korean population.
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- A Novel Variant Of Regenerating Iα Gene (REG) In Type II Diabetics Among Pakistani Targeted Population
Sadaf Saleem, Saeeda Baig, Sadia Farrukh, Mazhar Shafiq Journal of Rawalpindi Medical College.2023;[Epub] CrossRef - Glycemic Effects of Once-a-Day Rapid-Acting Insulin Analogue Addition on a Basal Insulin Analogue in Korean Subjects with Poorly Controlled Type 2 Diabetes Mellitus
Eun Yeong Choe, Yong-ho Lee, Byung-Wan Lee, Eun-Seok Kang, Bong Soo Cha, Hyun Chul Lee Diabetes & Metabolism Journal.2012; 36(3): 230. CrossRef
- Regulation of Glucose Control in People with Type 2 Diabetes: A Review and Consensus
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Jeong-Taek Woo, Kyung Soo Park, Dong-Won Byun, Kyung Soo Ko, Yoon-Sok Chung, Doo Man Kim, Tae Sun Park, Bong Soo Cha, In Kyu Lee, Joong Yeol Park, Hyun Shik Son, Moon-Kyu Lee, Kwang Won Kim, Ho Young Son
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Korean Diabetes J. 2010;34(1):16-20. Published online February 28, 2010
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DOI: https://doi.org/10.4093/kdj.2010.34.1.16
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A conference was convened by the Korean Diabetes Association and the Korean Endocrine Society on September 7, 2009 to discuss and organize the results of research on intensive glucose control for the prevention of cardiovascular disease in patients with type 2 diabetes. Professor Kyung Soo Park led the conference, and Professors Kwang Won Kim and Ho Young Son acted as chairmen. Professors Doo Man Kim, Tae Sun Park, and Bong Soo Cha reported on intensive glucose control and diabetic complications, including the UK Prospective Diabetes Study (UKPDS), Diabetes Control and Complication Trial (DCCT) research results, the recently published Action to Control Cardiovascular Risk in Diabetes (ACCORD), Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE), and Veterans Affairs Diabetes Trial (VADT) research, as well as meta-analyses. Professor Jeong-Taek Woo reported on the manuscript written by the committee for the Korean Diabetes Association which dealt with the treatment of diabetes mellitus. Professors Kyung Soo Ko, Joong Yeol Park, Hyun Shik Son, Moon-Kyu Lee, Dong-Won Byun, and Yoon-Sok Chung participated in the discussion and collected information for the manuscript from all of the participants. The aim of the debate was to determine how to establish target goals for intensive glucose control and how to individualize those goals. The participants concluded that there was no need to modify the recommendation of maintaining an HbA1c under 6.5%, the current blood glucose treatment goal that is recommended by the Korean Diabetes Association. In addition, individual target goals for glucose control were recommended depending on the situation of each patient. We report on the consensus statement from the meeting.
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- Long-term quality-of-care score for predicting the occurrence of acute myocardial infarction in patients with type 2 diabetes mellitus
Pi-I Li, How-Ran Guo World Journal of Diabetes.2023; 14(7): 1091. CrossRef
- Risk Factors Associated with Left Ventricular Diastolic Dysfunction in Type 2 Diabetic Patients without Hypertension
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Jung Hyun Noh, Joon Hyung Doh, Sung Yun Lee, Tae Nyun Kim, Hyuk Lee, Hwa Young Song, Jeong Hyun Park, Kyung Soo Ko, Byoung Doo Rhee, Dong Jun Kim
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Korean Diabetes J. 2010;34(1):40-46. Published online February 28, 2010
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DOI: https://doi.org/10.4093/kdj.2010.34.1.40
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Abstract
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- Background
Hypertension and age are recognized as important risk factors for left ventricular (LV) diastolic dysfunction. Some studies have shown that diabetes itself may also be an independent risk factor for LV diastolic dysfunction, although this is controversial. The aim of this study was to determine the factors associated with LV diastolic dysfunction in patients with type 2 diabetes in the absence of hypertension or ischemic heart disease (IHD). MethodsParticipants in this study consisted of 65 type 2 diabetes patients (M : F = 45 : 20; mean age 51 [26 to 76] years; mean body mass index [BMI] 25.0 ± 2.5 kg/m2) without hypertension, heart disease, or renal disease. Individuals with ischemic electrocardiographic changes were excluded. LV diastolic function was evaluated by Doppler echocardiographic studies. ResultsFifteen patients (23.1%) showed LV diastolic dysfunction on Doppler echocardiographic studies. Patients with LV diastolic dysfunction were older than those without diastolic dysfunction (60.0 ± 2.5 vs. 50.5 ± 1.9 years; P < 0.01). After adjusting for age and sex, BMI was higher (26.6 ± 0.7 vs. 24.6 ± 0.3 kg/m2; P < 0.01) and diabetes duration was longer (9.65 ± 1.48 vs. 4.71 ± 0.78 years; P < 0.01) in patients with LV diastolic dysfunction than in those without diastolic dysfunction. There were no differences in sex, smoking, blood pressure, lipid profiles, hemoglobin A1C, fasting glucose, fasting insulin, or diabetic microvascular complications between the LV diastolic dysfunction group and the normal diastolic function group. After adjusting for age, sex, and BMI, diabetes duration was found to be independently associated with LV diastolic dysfunction (odds ratio 1.38; confidence interval 1.12 to 1.72; P = 0.003). ConclusionThese results suggest that diabetes duration may be a risk factor for LV diastolic dysfunction in type 2 diabetic patients without hypertension or IHD.
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- Reducing Cardiac Steatosis: Interventions to Improve Diastolic Function: A Narrative Review
Kiyan Heshmat-Ghahdarijani, Roya Modaresi, Sobhan Pourmasjedi, Setayesh Sotoudehnia Korani, Ali Rezazadeh Roudkoli, Razieh Ziaei, Armita Farid, Mehrnaz Salehi, Afshin Heidari, Sina Neshat Current Problems in Cardiology.2023; 48(8): 101739. CrossRef - Glycemic variability is associated with diastolic dysfunction in patients with type 2 diabetes
Yana Dzhun, Georgy Mankovsky, Nadiya Rudenko, Yevgen Marushko, Yanina Saienko, Borys Mankovsky Journal of Diabetes and its Complications.2023; 37(11): 108519. CrossRef - Lipids and diastolic dysfunction: Recent evidence and findings
Padideh Daneii, Sina Neshat, Monir Sadat Mirnasiry, Zahra Moghimi, Fatemeh Dehghan Niri, Armita Farid, Setayesh Sotoudehnia Korani, Masood Shekarchizadeh, Kiyan Heshmat-Ghahdarijani Nutrition, Metabolism and Cardiovascular Diseases.2022; 32(6): 1343. CrossRef - Does diabetes increase the risk of cardiovascular events in patients with negative treadmill stress echocardiography?
So Young Yang, Hui-Jeong Hwang Endocrine Journal.2022; 69(7): 785. CrossRef - Factors associated with left ventricular diastolic dysfunction in patients with septic shock
Wei-Dong Ge, Feng-Zhi Li, Bang-Chuan Hu, Li-Hong Wang, Ding-Yuan Ren European Journal of Medical Research.2022;[Epub] CrossRef - An in-depth analysis of glycosylated haemoglobin level, body mass index and left ventricular diastolic dysfunction in patients with type 2 diabetes
Xin Zuo, Xueting Liu, Runtian Chen, Huiting Ou, Jiabao Lai, Youming Zhang, Dewen Yan BMC Endocrine Disorders.2019;[Epub] CrossRef - Early detection of left ventricular diastolic dysfunction using conventional and speckle tracking echocardiography in a large animal model of metabolic dysfunction
Mark M. P. van den Dorpel, Ilkka Heinonen, Sanne M. Snelder, Hendrik J. Vos, Oana Sorop, Ron T. van Domburg, Daphne Merkus, Dirk J. Duncker, Bas M. van Dalen The International Journal of Cardiovascular Imaging.2017;[Epub] CrossRef - Risk Factors Associated with Left Ventricular Diastolic Dysfunction in Type 2 Diabetic Patients without Hypertension (Korean Diabetes J 2010;34:40-6)
Dong-Lim Kim Korean Diabetes Journal.2010; 34(2): 135. CrossRef
- The Effect of Glucose Fluctuation on Apoptosis and Function of INS-1 Pancreatic Beta Cells
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Mi Kyung Kim, Hye Sook Jung, Chang Shin Yoon, Jung Hae Ko, Hae Jung Jun, Tae Kyun Kim, Min Jeong Kwon, Soon Hee Lee, Kyung Soo Ko, Byoung Doo Rhee, Jeong Hyun Park
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Korean Diabetes J. 2010;34(1):47-54. Published online February 28, 2010
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DOI: https://doi.org/10.4093/kdj.2010.34.1.47
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4,439
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Abstract
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- Background
Blood glucose level continuously fluctuates within a certain range in the human body. In diabetes patients, the extent of such fluctuation is large, despite the strict control of blood glucose. Blood glucose fluctuation has been shown to mediate more adverse effects on vascular endothelial cells and diabetes complications than chronic hyperglycemia, which has been explained as due to oxidative stress. As few previous studies have reported the effects of chronic and intermittent hyperglycemia on the apoptosis and function of pancreatic beta cells, this study reported herein was performed to investigate such effects on these cells. MethodsFor chronic hyperglycemia, INS-1 cells were cultured for 5 days with changes of RPMI 1640 medium containing 33 mM glucose every 12 hours. For intermittent hyperglycemia, the medium containing 11 mM glucose was exchanged with the medium containing 33 mM glucose every 12 hours. Apoptosis was assessed by TUNEL assay Hoechst staining and cleaved caspase 3. Insulin secretory capacity was assessed, and the expression of Mn-SOD and Bcl-2 was measured by Western blotting. ResultsIn comparison to the control group, INS-1 cells exposed to chronic hyperglycemia and intermittent hyperglycemia showed an increase in apoptosis. The apoptosis of INS-1 cells exposed to intermittent hyperglycemia increased significantly more than the apoptosis of INS-1 cells exposed to chronic hyperglycemia. In comparison to the control group, the insulin secretory capacity in the two hyperglycemic states was decreased, and more with intermittent hyperglycemia than with chronic hyperglycemia. The expression of Mn-SOD and Bcl-2 increased more with chronic hyperglycemia than with intermittent hyperglycemia. ConclusionIntermittent hyperglycemia induced a higher degree of apoptosis and decreased the insulin secretory capacity more in pancreatic beta cells than chronic hyperglycemia. This activity may be mediated by the anti-oxidative enzyme Mn-SOD and the anti-apoptotic signal Bcl-2.
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Laily Adninta, Indranila Samsuria, Edward Kurnia Setiawan Limijadi Open Access Macedonian Journal of Medical Sciences.2022; 10(B): 944. CrossRef - Age‐specific associations of glycated haemoglobin variability with cardiovascular disease and mortality in patients with type 2 diabetes mellitus: A 10‐ year cohort study
Eric Yuk Fai Wan, Esther Yee Tak Yu, Weng Yee Chin, Florence Ting Yan Ng, Shu Ming Cheryl Chia, Ian Chi Kei Wong, Esther Wai Yin Chan, Cindy Lo Kuen Lam Diabetes, Obesity and Metabolism.2020; 22(8): 1316. CrossRef - Molecular Mechanisms of Glucose Fluctuations on Diabetic Complications
Zhen-Ye Zhang, Ling-Feng Miao, Ling-Ling Qian, Ning Wang, Miao-Miao Qi, Yu-Min Zhang, Shi-Peng Dang, Ying Wu, Ru-Xing Wang Frontiers in Endocrinology.2019;[Epub] CrossRef - Resolution on the results of the first working meeting of the scientific advisory board «Actual problems of glycemic variability as a new criterion of glycemic control and safety of diabetes therapy»
Mikhail B. Antsiferov, Gagik R. Galstyan, Alexey V. Zilov, Alexander Y. Mayorov, Tatyana N. Markova, Nikolay A. Demidov, Olga M. Koteshkova, Dmitry N. Laptev, Alisa V. Vitebskaya Diabetes mellitus.2019; 22(3): 281. CrossRef - Intermittent High Glucose Enhances the Proliferation of Rat Aortic Vascular Smooth Muscle Cells More Than Constant High Glucose via the Mitogen-Activated Protein Kinase Pathway
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Eric Yuk Fai Wan, Colman Siu Cheung Fung, Daniel Yee Tak Fong, Cindy Lo Kuen Lam Journal of Diabetes and its Complications.2016; 30(7): 1240. CrossRef - Ginsenoside Rg3 prevents INS-1 cell death from intermittent high glucose stress
You Jeong Kim, Su Min Park, Hye Sook Jung, Eun Ju Lee, Tae Kyoon Kim, Tae-Nyun Kim, Min Jeong Kwon, Soon Hee Lee, Byoung Doo Rhee, Mi-kyung Kim, Jeong Hyun Park Islets.2016; 8(3): 57. CrossRef - Different antihyperglycaemic drug effects on glycaemic variability in Type 2 diabetic patients
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