Diabetes & Metabolism Journal

Kyung Ah Han (Han KA)

17 Articles

Drug/Regimen
Pioglitazone as Add-on Therapy in Patients with Type 2 Diabetes Mellitus Inadequately Controlled with Dapagliflozin and Metformin: Double-Blind, Randomized, Placebo-Controlled Trial: Ji Hye Heo, Kyung Ah Han, Jun Hwa Hong, Hyun-Ae Seo, Eun-Gyoung Hong, Jae Myung Yu, Hye Seung Jung, Bong-Soo Cha; Diabetes Metab J. 2024;48(5):937-948. Published online February 2, 2024; DOI: https://doi.org/10.4093/dmj.2023.0314

6,811 View
483 Download
1 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background
This study assessed the efficacy and safety of triple therapy with pioglitazone 15 mg add-on versus placebo in patients with type 2 diabetes mellitus (T2DM) inadequately controlled with metformin and dapagliflozin.
Methods
In this multicenter, double-blind, randomized, phase 3 study, patients with T2DM with an inadequate response to treatment with metformin (≥1,000 mg/day) plus dapagliflozin (10 mg/day) were randomized to receive additional pioglitazone 15 mg/day (n=125) or placebo (n=125) for 24 weeks. The primary endpoint was the change in glycosylated hemoglobin (HbA1c) levels from baseline to week 24 (ClinicalTrials.gov identifier: NCT05101135).
Results
At week 24, the adjusted mean change from baseline in HbA1c level compared with placebo was significantly greater with pioglitazone treatment (–0.47%; 95% confidence interval, –0.61 to –0.33; P<0.0001). A greater proportion of patients achieved HbA1c <7% or <6.5% at week 24 with pioglitazone compared to placebo as add-on to 10 mg dapagliflozin and metformin (56.8% vs. 28% for HbA1c <7%, and 23.2% vs. 9.6% for HbA1c <6.5%; P<0.0001 for all). The addition of pioglitazone also significantly improved triglyceride, highdensity lipoprotein cholesterol levels, and homeostatic model assessment of insulin resistance levels, while placebo did not. The incidence of treatment-emergent adverse events was similar between the groups, and the incidence of fluid retention-related side effects by pioglitazone was low (1.5%).
Conclusion
Triple therapy with the addition of 15 mg/day of pioglitazone to dapagliflozin plus metformin was well tolerated and produced significant improvements in HbA1c in patients with T2DM inadequately controlled with dapagliflozin plus metformin.

Citations

Citations to this article as recorded by

Ideal Combination of Oral Hypoglycemic Agents for Patients with Type 2 Diabetes Mellitus
Hye Soon Kim
Diabetes & Metabolism Journal.2024; 48(5): 882. CrossRef

Drug/Regimen
Efficacy and Safety of Alogliptin-Pioglitazone Combination for Type 2 Diabetes Mellitus Poorly Controlled with Metformin: A Multicenter, Double-Blind Randomized Trial: Ji-Yeon Park, Joonyub Lee, Yoon-Hee Choi, Kyung Wan Min, Kyung Ah Han, Kyu Jeung Ahn, Soo Lim, Young-Hyun Kim, Chul Woo Ahn, Kyung Mook Choi, Kun-Ho Yoon, the Practical Evidence of Antidiabetic Combination Therapy in Korea (PEAK) study investigators; Diabetes Metab J. 2024;48(5):915-928. Published online April 23, 2024; DOI: https://doi.org/10.4093/dmj.2023.0259

3,145 View
278 Download

Abstract PDF Supplementary Material PubReader ePub: Background
Guidelines for switching to triple combination therapy directly after monotherapy failure are limited. This study investigated the efficacy, long-term sustainability, and safety of either mono or dual add-on therapy using alogliptin and pioglitazone for patients with type 2 diabetes mellitus (T2DM) who did not achieve their target glycemic range with metformin monotherapy.
Methods
The Practical Evidence of Antidiabetic Combination Therapy in Korea (PEAK) was a multicenter, placebo-controlled, double-blind, randomized trial. A total of 214 participants were randomized to receive alogliptin+pioglitazone (Alo+Pio group, n=70), alogliptin (Alo group, n=75), or pioglitazone (Pio group, n=69). The primary outcome was the difference in glycosylated hemoglobin (HbA1c) levels between the three groups at baseline to 24 weeks. For durability, the achievement of HbA1c levels <7% and <6.5% was compared in each group. The number of adverse events was investigated for safety.
Results
After 24 weeks of treatment, the change of HbA1c in the Alo+Pio, Alo, and Pio groups were –1.38%±0.08%, –1.03%±0.08%, and –0.84%±0.08%, respectively. The Alo+Pio group had significantly lower HbA1c levels than the other groups (P=0.0063, P<0.0001) and had a higher proportion of patients with target HbA1c achievement. In addition, insulin sensitivity and β-cell function, lipid profiles, and other metabolic indicators were also improved. There were no significant safety issues in patients treated with triple combination therapy.
Conclusion
Early combination triple therapy showed better efficacy and durability than the single add-on (dual) therapy. Therefore, combination therapy with metformin, alogliptin, and pioglitazone is a valuable early treatment option for T2DM poorly controlled with metformin monotherapy.

Drug Regimen
Efficacy and Safety of Enavogliflozin versus Dapagliflozin as Add-on to Metformin in Patients with Type 2 Diabetes Mellitus: A 24-Week, Double-Blind, Randomized Trial: Kyung Ah Han, Yong Hyun Kim, Doo Man Kim, Byung Wan Lee, Suk Chon, Tae Seo Sohn, In Kyung Jeong, Eun-Gyoung Hong, Jang Won Son, Jae Jin Nah, Hwa Rang Song, Seong In Cho, Seung-Ah Cho, Kun Ho Yoon; Diabetes Metab J. 2023;47(6):796-807. Published online February 9, 2023; DOI: https://doi.org/10.4093/dmj.2022.0315

43,046 View
707 Download
7 Web of Science
8 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background
Enavogliflozin is a novel sodium-glucose cotransporter-2 inhibitor currently under clinical development. This study evaluated the efficacy and safety of enavogliflozin as an add-on to metformin in Korean patients with type 2 diabetes mellitus (T2DM) against dapagliflozin.
Methods
In this multicenter, double-blind, randomized, phase 3 study, 200 patients were randomized to receive enavogliflozin 0.3 mg/day (n=101) or dapagliflozin 10 mg/day (n=99) in addition to ongoing metformin therapy for 24 weeks. The primary objective of the study was to prove the non-inferiority of enavogliflozin to dapagliflozin in glycosylated hemoglobin (HbA1c) change at week 24 (non-inferiority margin of 0.35%) (Clinical trial registration number: NCT04634500).
Results
Adjusted mean change of HbA1c at week 24 was –0.80% with enavogliflozin and –0.75% with dapagliflozin (difference, –0.04%; 95% confidence interval, –0.21% to 0.12%). Percentages of patients achieving HbA1c <7.0% were 61% and 62%, respectively. Adjusted mean change of fasting plasma glucose at week 24 was –32.53 and –29.14 mg/dL. An increase in urine glucose-creatinine ratio (60.48 vs. 44.94, P<0.0001) and decrease in homeostasis model assessment of insulin resistance (–1.85 vs. –1.31, P=0.0041) were significantly greater with enavogliflozin than dapagliflozin at week 24. Beneficial effects of enavogliflozin on body weight (–3.77 kg vs. –3.58 kg) and blood pressure (systolic/diastolic, –5.93/–5.41 mm Hg vs. –6.57/–4.26 mm Hg) were comparable with those of dapagliflozin, and both drugs were safe and well-tolerated.
Conclusion
Enavogliflozin added to metformin significantly improved glycemic control in patients with T2DM and was non-inferior to dapagliflozin 10 mg, suggesting enavogliflozin as a viable treatment option for patients with inadequate glycemic control on metformin alone.

Citations

Citations to this article as recorded by

Efficacy and safety of enavogliflozin vs. dapagliflozin as add-on therapy in patients with type 2 diabetes mellitus based on renal function: a pooled analysis of two randomized controlled trials
Young Sang Lyu, Sangmo Hong, Si Eun Lee, Bo Young Cho, Cheol-Young Park
Cardiovascular Diabetology.2024;[Epub] CrossRef
A 52‐week efficacy and safety study of enavogliflozin versus dapagliflozin as an add‐on to metformin in patients with type 2 diabetes mellitus: ENHANCE‐M extension study
Tae Seo Sohn, Kyung‐Ah Han, Yonghyun Kim, Byung‐Wan Lee, Suk Chon, In‐Kyung Jeong, Eun‐Gyoung Hong, Jang Won Son, JaeJin Na, Jae Min Cho, Seong In Cho, Wan Huh, Kun‐Ho Yoon
Diabetes, Obesity and Metabolism.2024; 26(6): 2248. CrossRef
The effect of renal function on the pharmacokinetics and pharmacodynamics of enavogliflozin, a potent and selective sodium‐glucose cotransporter‐2 inhibitor, in type 2 diabetes
Sae Im Jeong, Mu Seong Ban, Jun‐Gi Hwang, Min‐Kyu Park, Soo Lim, Sejoong Kim, Soon Kil Kwon, Yoonjin Kim, Jae Min Cho, Jae Jin Na, Wan Huh, Jae‐Yong Chung
Diabetes, Obesity and Metabolism.2024; 26(7): 2588. CrossRef
Long‐term efficacy and safety of enavogliflozin in Korean people with type 2 diabetes: A 52‐week extension of a Phase 3 randomized controlled trial
Soo Heon Kwak, Kyung Ah Han, Eun Sook Kim, Sung Hee Choi, Jong Chul Won, Jae Myung Yu, Seungjoon Oh, Hye Jin Yoo, Chong Hwa Kim, Kyung‐Soo Kim, SungWan Chun, Yong Hyun Kim, Seung Ah Cho, Da Hye Kim, Kyong Soo Park
Diabetes, Obesity and Metabolism.2024; 26(10): 4203. CrossRef
Role of novel sodium glucose co-transporter-2 inhibitor enavogliflozin in type-2 diabetes: A systematic review and meta-analysis
Deep Dutta, B.G. Harish, Beatrice Anne, Lakshmi Nagendra
Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2023; 17(8): 102816. CrossRef
Characteristics of the Latest Therapeutic Agent for Diabetes
Nuri Yun
The Journal of Korean Diabetes.2023; 24(3): 148. CrossRef
Prospects of using sodium-glucose co-transporter-2 (SGLT-2) inhibitors in patients with metabolic-associated fatty liver disease (MAFLD)
Iryna Kostitska, Nadia Protas, Liliia Petrovska
Diabetes Obesity Metabolic Syndrome.2023; (5): 8. CrossRef
Navigating the Future of Diabetes Treatment with New Drugs: Focusing on the Possibilities and Prospects of Enavogliflozin
Sang Youl Rhee
Diabetes & Metabolism Journal.2023; 47(6): 769. CrossRef

Drug Regimen
Efficacy and Safety of Evogliptin Add-on Therapy to Dapagliflozin/Metformin Combinations in Patients with Poorly Controlled Type 2 Diabetes Mellitus: A 24-Week Multicenter Randomized Placebo-Controlled Parallel-Design Phase-3 Trial with a 28-Week Extension: Jun Sung Moon, Il Rae Park, Hae Jin Kim, Choon Hee Chung, Kyu Chang Won, Kyung Ah Han, Cheol-Young Park, Jong Chul Won, Dong Jun Kim, Gwan Pyo Koh, Eun Sook Kim, Jae Myung Yu, Eun-Gyoung Hong, Chang Beom Lee, Kun-Ho Yoon; Diabetes Metab J. 2023;47(6):808-817. Published online September 26, 2023; DOI: https://doi.org/10.4093/dmj.2022.0387

4,823 View
412 Download
1 Web of Science
1 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background
This study investigates the long-term efficacy and safety of evogliptin add-on therapy in patients with inadequately controlled type 2 diabetes mellitus (T2DM) previously received dapagliflozin and metformin (DAPA/MET) combination.
Methods
In this multicenter randomized placebo-controlled phase 3 trial, patients with glycosylated hemoglobin (HbA1c) levels 7.0% to 10.5% (n=283) previously used DAPA 10 mg plus MET (≥1,000 mg) were randomly assigned to the evogliptin 5 mg once daily or placebo group (1:1). The primary endpoint was the difference in the HbA1c level from baseline at week 24, and exploratory endpoints included the efficacy and safety of evogliptin over 52 weeks (trial registration: ClinicalTrials.gov NCT04170998).
Results
Evogliptin add-on to DAPA/MET therapy was superior in HbA1c reduction compared to placebo at weeks 24 and 52 (least square [LS] mean difference, –0.65% and –0.55%; 95% confidence interval [CI], –0.79 to –0.51 and –0.71 to –0.39; P<0.0001). The proportion of patients achieving HbA1c <7% was higher in the triple combination group at week 52 (32.14% vs. 8.51% in placebo; odds ratio, 5.62; P<0.0001). Evogliptin significantly reduced the fasting glucose levels and mean daily glucose levels with improvement in homeostatic model assessment of β-cell function (LS mean difference, 9.04; 95% CI, 1.86 to 16.21; P=0.0138). Adverse events were similar between the groups, and no serious adverse drug reactions were reported in the evogliptin group.
Conclusion
Long-term triple combination with evogliptin added to DAPA/MET showed superior HbA1c reduction and glycemic control compared to placebo at 52 weeks and was well tolerated.

Citations

Citations to this article as recorded by

Efficacy and safety of dapagliflozin add‐on to evogliptin plus metformin therapy in patients with type 2 diabetes: A randomized, double‐blind, placebo‐controlled study
In‐Kyung Jeong, Kyung Mook Choi, Kyung Ah Han, Kyoung‐Ah Kim, In Joo Kim, Seung Jin Han, Won Young Lee, Soon Jib Yoo
Diabetes, Obesity and Metabolism.2024; 26(11): 5065. CrossRef

Lifestyle
Body Fat Is Related to Sedentary Behavior and Light Physical Activity but Not to Moderate-Vigorous Physical Activity in Type 2 Diabetes Mellitus: Keun Hee An, Kyung Ah Han, Tae Seo Sohn, Ie Byung Park, Hae Jin Kim, Sung Dae Moon, Kyung Wan Min; Diabetes Metab J. 2020;44(2):316-325. Published online November 12, 2019; DOI: https://doi.org/10.4093/dmj.2019.0029

6,721 View
149 Download
11 Web of Science
12 Crossref

Abstract PDF PubReader

Background

Sedentary behavior (SB) has emerged as a new risk factor for cardiovascular accidents. We investigated whether physical activity levels or SB were related to percent body fat (%BF) in type 2 diabetes mellitus (T2DM).

Methods

In this cross sectional study, we measured the duration of SB, light physical activity (LPA), moderate to vigorous physical activity (MVPA), total energy expenditure, and step counts using a wireless activity tracker (Fitbit HR; FB) for 7 days in free-living conditions, along with %BF using a bio impedance analyzer (Inbody; Biospace) in 120 smartphone users with T2DM. Subjects were divided into exercise (Exe, n=68) and non-exercise (nonExe, n=52) groups based on self-reports of whether the recommended exercises (30 min/day, 3 days/week for 3 months) were performed. SBt, LPAt, MVPAt were transformed from SB, LPA, MVPA for normally distributed variables.

Results

Participants were: female, 59.2%; age, 59.3±8.4 years; body mass index, 25.5±3.4 kg/m²; glycosylated hemoglobin (HbA1c), 7.6%±1.2%; %BF, 30.4%±7.1%. They performed SB for 15.7±3.7 hr/day, LPA for 4.4±1.7 hr/day, and MVPA for 0.9±0.8 hr/day. The %BF was related to SBt and LPAt, but not to MVPA after adjustments for age, gender, and HbA1c. VPA was significantly higher in the Exe group than in the nonExe group, but SB, LPA, and moderate physical activity were not different. Predicted %BF was 89.494 to 0.105 (age), −13.047 (gender), −0.507 (HbA1c), −7.655 (LPAt) (F[4, 64]=62.929, P<0.001), with an R² of 0.785 in multiple linear regression analysis.

Conclusion

Reduced body fat in elderly diabetic patients might be associated with reduced inactivity and increased LPA.

Citations

Citations to this article as recorded by

The Power of Movement: Linking Physical Activity with Nutritional Health and Blood Sugar Balance in a Dalmatian Type 2 Diabetic Population
Josipa Radić, Andrej Belančić, Hana Đogaš, Marijana Vučković, Tina Đogaš, Leida Tandara, Marina Grubić, Lucija Šolić Šegvić, Ivana Novak, Mislav Radić
Nutrients.2025; 17(1): 187. CrossRef
Explanatory variables of objectively measured 24-h movement behaviors in people with prediabetes and type 2 diabetes: A systematic review
Lotte Bogaert, Iris Willems, Patrick Calders, Eveline Dirinck, Manon Kinaupenne, Marga Decraene, Bruno Lapauw, Boyd Strumane, Margot Van Daele, Vera Verbestel, Marieke De Craemer
Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2024; 18(4): 102995. CrossRef
Associations of nonoccupational sedentary behaviors with cardiometabolic outcomes: coronary artery risk development in young adults (CARDIA)
Gabriel Zieff, Michael P Bancks, Kelley Pettee Gabriel, Bethany Barone Gibbs, Justin B Moore, Jared P Reis, Keeron Stone, Lee Stoner
Annals of Behavioral Medicine.2024;[Epub] CrossRef
Association between depression, anemia and physical activity using isotemporal substitution analysis
Hee-kyoung Nam, Jungmi Park, Sung-il Cho
BMC Public Health.2023;[Epub] CrossRef
The Impact of Wearable Technologies in Health Research: Scoping Review
Sophie Huhn, Miriam Axt, Hanns-Christian Gunga, Martina Anna Maggioni, Stephen Munga, David Obor, Ali Sié, Valentin Boudo, Aditi Bunker, Rainer Sauerborn, Till Bärnighausen, Sandra Barteit
JMIR mHealth and uHealth.2022; 10(1): e34384. CrossRef
The Correlation of Prediabetes and Type 2 Diabetes With Adiposity in Adults
Juan Sun, Zhen Liu, Zimu Zhang, Ziyang Zeng, Weiming Kang
Frontiers in Nutrition.2022;[Epub] CrossRef
The Physical Activity Assessment of Adults With Type 2 Diabetes Using Accelerometer-Based Cut Points: Scoping Review
Ioana A Moldovan, Alexa Bragg, Anna S Nidhiry, Barbara A De La Cruz, Suzanne E Mitchell
Interactive Journal of Medical Research.2022; 11(2): e34433. CrossRef
Effects of 4 Weeks of a Technique-Specific Protocol with High-Intensity Intervals on General and Specific Physical Fitness in Taekwondo Athletes: An Inter-Individual Analysis
Alex Ojeda-Aravena, Tomás Herrera-Valenzuela, Pablo Valdés-Badilla, Jorge Cancino-López, José Zapata-Bastias, José Manuel García-García
International Journal of Environmental Research and Public Health.2021; 18(7): 3643. CrossRef
Inter-Individual Variability of a High-Intensity Interval Training With Specific Techniques vs. Repeated Sprints Program in Sport-Related Fitness of Taekwondo Athletes
Alex Ojeda-Aravena, Tomás Herrera-Valenzuela, Pablo Valdés-Badilla, Jorge Cancino-López, José Zapata-Bastias, José Manuel García-García
Frontiers in Physiology.2021;[Epub] CrossRef
EFFECT OF SPORTS MEDICINE ON REDUCING BODY FAT PERCENTAGE AND LEAN BODY MASS
Chunyan Fan
Revista Brasileira de Medicina do Esporte.2021; 27(7): 714. CrossRef
Validation of the effectiveness of a digital integrated healthcare platform utilizing an AI-based dietary management solution and a real-time continuous glucose monitoring system for diabetes management: a randomized controlled trial
Sung Woon Park, Gyuri Kim, You-Cheol Hwang, Woo Je Lee, Hyunjin Park, Jae Hyeon Kim
BMC Medical Informatics and Decision Making.2020;[Epub] CrossRef
Brain activity during a working memory task in different postures: an EEG study
Ju-Yeon Jung, Hwi-Young Cho, Chang-Ki Kang
Ergonomics.2020; 63(11): 1359. CrossRef

Arterial Stiffness by Aerobic Exercise Is Related with Aerobic Capacity, Physical Activity Energy Expenditure and Total Fat but not with Insulin Sensitivity in Obese Female Patients with Type 2 Diabetes: Ji Yeon Jung, Kyung Wan Min, Hee Jung Ahn, Hwi Ryun Kwon, Jae Hyuk Lee, Kang Seo Park, Kyung Ah Han; Diabetes Metab J. 2014;38(6):439-448. Published online December 15, 2014; DOI: https://doi.org/10.4093/dmj.2014.38.6.439

5,728 View
39 Download
11 Web of Science
7 Crossref

Abstract PDF PubReader

Background

Arterial stiffness is an important factor in atherosclerosis. Thus we examined whether aerobic exercise could reduce arterial stiffness in obese women with type 2 diabetes without diabetic complication.

Methods

A total of 35 women with type 2 diabetes (body mass index, 26.6±2.8 kg/m²; age, 56.4±1.9 years; duration of diabetes, 4.7±4.8 years) were assigned to aerobic exercise group (AEG) or control group (CG). AEG completed a 12-week exercise program (3.6 to 5.2 metabolic equivalents, 3 day/week, 60 min/day), with their exercise activities monitored by accelerometers. We measured abdominal total fat area (TFA), visceral fat area (VFA), and subcutaneous fat area (SFA) by computed tomography, insulin sensitivity by insulin tolerance test (K_ITT), and augmentation index (AIx) by SphygmoCor at baseline and at the end of the 12-week program.

Results

The AIx was improved in the AEG compared with the CG (P<0.001). The percent change of AIx had significant correlation with the improvement of physical activity energy expenditure (PAEE), aerobic capacity, TFA, and SFA (r=-0.416, P=0.013; r=0.560, P<0.001; r=0.489, P=0.003; r=0.531, P=0.001, respectively), but not with insulin sensitivity, energy intake, or VFA.

Conclusion

Improvement in aortic stiffness by aerobic exercise is related with the improvement of aerobic capacity, PAEE, and total fat but not with insulin sensitivity or energy intake in obese women with type 2 diabetes.

Citations

Citations to this article as recorded by

Relationship between objectively measured physical activity and subclinical cardiovascular disease: a systematic review
Aparna Narendrula, Ellen Brinza, Christine Horvat Davey, Chris T Longenecker, Allison R Webel
BMJ Open Sport & Exercise Medicine.2024; 10(1): e001596. CrossRef
The Effects of Exercise Interventions on Ectopic and Subcutaneous Fat in Patients with Type 2 Diabetes Mellitus: A Systematic Review, Meta-Analysis, and Meta-Regression
Fatemeh Kazeminasab, Ali Bahrami Kerchi, Nasim Behzadnejad, Saba Belyani, Sara K. Rosenkranz, Reza Bagheri, Fred Dutheil
Journal of Clinical Medicine.2024; 13(17): 5005. CrossRef
Aerobic training reduces pancreatic fat content and improves β‐cell function: A randomized controlled trial using IDEAL‐IQ magnetic resonance imaging
Min Li, Qidong Zheng, Joshua D. Miller, Panpan Zuo, Xiaodan Yuan, Jitao Feng, Chao Liu, Shan Bao, Qingqing Lou
Diabetes/Metabolism Research and Reviews.2022;[Epub] CrossRef
Effect of aerobic exercise on waist circumference in adults with overweight or obesity: A systematic review and meta‐analysis
Alex Armstrong, Klaus Jungbluth Rodriguez, Angelo Sabag, Yorgi Mavros, Helen M. Parker, Shelley E. Keating, Nathan A. Johnson
Obesity Reviews.2022;[Epub] CrossRef
Aortic waveform responses to insulin in late versus early chronotype with metabolic syndrome
Mary‐Margaret E. Remchak, Emily M. Heiston, Anna Ballantyne, Brielle L. Dotson, Steven K. Malin
Physiological Reports.2022;[Epub] CrossRef
Exercise and ectopic fat in type 2 diabetes: A systematic review and meta-analysis
A. Sabag, K.L. Way, S.E. Keating, R.N. Sultana, H.T. O’Connor, M.K. Baker, V.H. Chuter, J. George, N.A. Johnson
Diabetes & Metabolism.2017; 43(3): 195. CrossRef
Arterial Stiffness Measured with the Cuff Oscillometric Method Is Predictive of Exercise Capacity in Patients with Cardiac Diseases
Yasushi Tazawa, Nobuyoshi Mori, Yoshiko Ogawa, Osamu Ito, Masahiro Kohzuki
The Tohoku Journal of Experimental Medicine.2016; 239(2): 127. CrossRef

Effects of Aerobic Exercise Intensity on Abdominal and Thigh Adipose Tissue and Skeletal Muscle Attenuation in Overweight Women with Type 2 Diabetes Mellitus: Ji Yeon Jung, Kyung Ah Han, Hee Jung Ahn, Hwi Ryun Kwon, Jae Hyuk Lee, Kang Seo Park, Kyung Wan Min; Diabetes Metab J. 2012;36(3):211-221. Published online June 14, 2012; DOI: https://doi.org/10.4093/dmj.2012.36.3.211

5,460 View
47 Download
24 Crossref

Abstract PDF PubReader

Background

We investigated the effects of exercise intensity on abdominal and mid-thigh adipose tissue, attenuation of skeletal muscle, and insulin sensitivity in overweight women with type 2 diabetes mellitus (T2DM).

Methods

Twenty-eight patients were randomly assigned to control (CG, n=12), moderate intensity exercise (MEG, n=8), or vigorous intensity exercise (VEG, n=8) group. Subjects in both exercise groups completed a 12-week exercise program (MEG, 3.6 to 5.2 METs; VEG, ≥5.2 METs) that was monitored by accelerometers. We assessed body mass index (BMI), total fat area (TFA), visceral fat area (VFA), subcutaneous fat area (SFA), mid-thigh intramuscular adipose tissue (TIMAT), total skeletal muscle (TTM), low density skeletal muscle (TLDM), and normal density skeletal muscle (TNDM) using computed tomography, and measured insulin sensitivity with an insulin tolerance test (K_ITT), before and after the intervention.

Results

At baseline, the mean age was 53.8±7.9 years, duration of diabetes was 3.8±2.3 years, and BMI was 26.6±2.6 kg/m². After 12 weeks, the percent change (%C) in BMI, TIMAT, and TLDM were not different among three groups. However, %C in TFA and VFA were significantly reduced in MEG compared to CG (P=0.026 and P=0.008, respectively). %C SFA was significantly reduced in VEG compared to CG (P=0.038) and %C TTM, TNDM, and K_ITT were significantly increased in VEG compared to the CG (P=0.044, P=0.007, and P=0.016, respectively).

Conclusion

Although there was no difference in the change in BMI among groups, TFA and VFA were more reduced in MEG, and only VEG increased TTM, TNDM, and insulin sensitivity compared to CG.

Citations

Citations to this article as recorded by

The Effects of Exercise Interventions on Ectopic and Subcutaneous Fat in Patients with Type 2 Diabetes Mellitus: A Systematic Review, Meta-Analysis, and Meta-Regression
Fatemeh Kazeminasab, Ali Bahrami Kerchi, Nasim Behzadnejad, Saba Belyani, Sara K. Rosenkranz, Reza Bagheri, Fred Dutheil
Journal of Clinical Medicine.2024; 13(17): 5005. CrossRef
Aerobic Exercise and Weight Loss in Adults
Ahmad Jayedi, Sepideh Soltani, Alireza Emadi, Mahdieh-Sadat Zargar, Ali Najafi
JAMA Network Open.2024; 7(12): e2452185. CrossRef
Intermuscular adipose tissue in metabolic disease
Bret H. Goodpaster, Bryan C. Bergman, Andrea M. Brennan, Lauren M. Sparks
Nature Reviews Endocrinology.2023; 19(5): 285. CrossRef
Dose–response effects of exercise and caloric restriction on visceral adiposity in overweight and obese adults: a systematic review and meta-analysis of randomised controlled trials
Francesco Recchia, Chit K. Leung, Angus P. Yu, Welton Leung, Danny J. Yu, Daniel Y. Fong, David Montero, Chi-Ho Lee, Stephen H.S. Wong, Parco M. Siu
British Journal of Sports Medicine.2023; 57(16): 1035. CrossRef
Muscle quality: the assessment, prognosis, and intervention
翔畑中, 洋祐大須賀
Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics.2023; 60(2): 103. CrossRef
Associations of Muscle Density and Area With Coronary Artery Plaque and Physical Function
Kristine M. Erlandson, Triin Umbleja, Michael T. Lu, Jana Taron, Heather J. Ribaudo, Edgar T. Overton, Rachel M. Presti, David W. Haas, Paul E. Sax, Michael T. Yin, Bingxue Kris Zhai, Rochelle Louis, Namrata Upadhyay, Parastou Eslami, Pamela S. Douglas, M
JAIDS Journal of Acquired Immune Deficiency Syndromes.2023; 94(2): 174. CrossRef
Aerobic training reduces pancreatic fat content and improves β‐cell function: A randomized controlled trial using IDEAL‐IQ magnetic resonance imaging
Min Li, Qidong Zheng, Joshua D. Miller, Panpan Zuo, Xiaodan Yuan, Jitao Feng, Chao Liu, Shan Bao, Qingqing Lou
Diabetes/Metabolism Research and Reviews.2022;[Epub] CrossRef
Effect of aerobic exercise on waist circumference in adults with overweight or obesity: A systematic review and meta‐analysis
Alex Armstrong, Klaus Jungbluth Rodriguez, Angelo Sabag, Yorgi Mavros, Helen M. Parker, Shelley E. Keating, Nathan A. Johnson
Obesity Reviews.2022;[Epub] CrossRef
Effect of exercise on myosteatosis in adults: a systematic review and meta-analysis
Robinson Ramírez-Vélez, Yasmin Ezzatvar, Mikel Izquierdo, Antonio García-Hermoso
Journal of Applied Physiology.2021; 130(1): 245. CrossRef
Effect of exercise intervention dosage on reducing visceral adipose tissue: a systematic review and network meta-analysis of randomized controlled trials
Yu-Hsuan Chang, Hui-Ying Yang, Shiow-Ching Shun
International Journal of Obesity.2021; 45(5): 982. CrossRef
Exercise Training to Decrease Ectopic Intermuscular Adipose Tissue in Individuals With Chronic Diseases: A Systematic Review and Meta-Analysis
Mauro Tuñón-Suárez, Alvaro Reyes-Ponce, Rodrigo Godoy-Órdenes, Nicolás Quezada, Marcelo Flores-Opazo
Physical Therapy.2021;[Epub] CrossRef
Low-attenuation muscle is a predictor of diabetes mellitus: A population-based cohort study
Muhei Tanaka, Hiroshi Okada, Yoshitaka Hashimoto, Muneaki Kumagai, Hiromi Nishimura, Michiaki Fukui
Nutrition.2020; 74: 110752. CrossRef
Drop-out ratio between moderate to high-intensity physical exercise treatment by patients with, or at risk of, type 2 diabetes mellitus: A systematic review and meta-analysis
Guillem Jabardo-Camprubí, Rafel Donat-Roca, Mercè Sitjà-Rabert, Raimon Milà-Villarroel, Judit Bort-Roig
Physiology & Behavior.2020; 215: 112786. CrossRef
High-Intensity Interval Training Versus Moderate-Intensity Continuous Training in Middle-Aged and Older Patients with Type 2 Diabetes: A Randomized Controlled Crossover Trial of the Acute Effects of Treadmill Walking on Glycemic Control
Romeu Mendes, Nelson Sousa, José Luís Themudo-Barata, Victor Machado Reis
International Journal of Environmental Research and Public Health.2019; 16(21): 4163. CrossRef
Trunk muscle quality assessed by computed tomography: Association with adiposity indices and glucose tolerance in men
Alexandre Maltais, Natalie Alméras, Isabelle Lemieux, Angelo Tremblay, Jean Bergeron, Paul Poirier, Jean-Pierre Després
Metabolism.2018; 85: 205. CrossRef
Counting Footsteps with a Pedometer to Improve HMW Adiponectin and Metabolic Syndrome among Young Female Adults in the United Arab Emirates
Hayder Hasan, Amita Attlee, Hamid Jan Bin Jan Mohamed, Norliyana Aris, Wan Abdul Manan Bin Wan Muda
Journal of Obesity.2018; 2018: 1. CrossRef
Exercise and ectopic fat in type 2 diabetes: A systematic review and meta-analysis
A. Sabag, K.L. Way, S.E. Keating, R.N. Sultana, H.T. O’Connor, M.K. Baker, V.H. Chuter, J. George, N.A. Johnson
Diabetes & Metabolism.2017; 43(3): 195. CrossRef
Effect of aerobic exercise intensity on glycemic control in type 2 diabetes: a meta-analysis of head-to-head randomized trials
Yilina Liubaoerjijin, Tasuku Terada, Kevin Fletcher, Normand G. Boulé
Acta Diabetologica.2016; 53(5): 769. CrossRef
A systematic review and meta‐analysis on the effects of exercise training versus hypocaloric diet: distinct effects on body weight and visceral adipose tissue
R. J. H. M. Verheggen, M. F. H. Maessen, D. J. Green, A. R. M. M. Hermus, M. T. E. Hopman, D. H. T. Thijssen
Obesity Reviews.2016; 17(8): 664. CrossRef
Muscle wasting and aging: Experimental models, fatty infiltrations, and prevention
Thomas Brioche, Allan F. Pagano, Guillaume Py, Angèle Chopard
Molecular Aspects of Medicine.2016; 50: 56. CrossRef
Arterial Stiffness by Aerobic Exercise Is Related with Aerobic Capacity, Physical Activity Energy Expenditure and Total Fat but not with Insulin Sensitivity in Obese Female Patients with Type 2 Diabetes
Ji Yeon Jung, Kyung Wan Min, Hee Jung Ahn, Hwi Ryun Kwon, Jae Hyuk Lee, Kang Seo Park, Kyung Ah Han
Diabetes & Metabolism Journal.2014; 38(6): 439. CrossRef
Intermuscular Fat: A Review of the Consequences and Causes
Odessa Addison, Robin L. Marcus, Paul C. LaStayo, Alice S. Ryan
International Journal of Endocrinology.2014; 2014: 1. CrossRef
Relative Skeletal Muscle Mass Is Associated with Development of Metabolic Syndrome
Byung Sam Park, Ji Sung Yoon
Diabetes & Metabolism Journal.2013; 37(6): 458. CrossRef
Effect of exercise on abdominal fat loss in men and women with and without type 2 diabetes
Devon A Dobrosielski, Bethany Barone Gibbs, Sameer Chaudhari, Pamela Ouyang, Harry A Silber, Kerry J Stewart
BMJ Open.2013; 3(11): e003897. CrossRef

Cardiovascular Risk Assessment with Vascular Function, Carotid Atherosclerosis and the UKPDS Risk Engine in Korean Patients with Newly Diagnosed Type 2 Diabetes: Choon Sik Seon, Kyung Wan Min, Seung Yup Lee, Kyoung Woo Nho, Se Hwan Park, Bo Kyung Koo, Kyung Ah Han; Diabetes Metab J. 2011;35(6):619-627. Published online December 26, 2011; DOI: https://doi.org/10.4093/dmj.2011.35.6.619

4,698 View
39 Download
10 Crossref

Abstract PDF PubReader

Background

Patients with type 2 diabetes have an increased risk of cardiovascular disease. Few studies have evaluated the cardiovascular disease (CVD) risk simultaneously using the United Kingdom Prospective Diabetes Study (UKPDS) risk engine and non-invasive vascular tests in patients with newly diagnosed type 2 diabetes.

Methods

Participants (n=380; aged 20 to 81 years) with newly diagnosed type 2 diabetes were free of clinical evidence of CVD. The 10-year coronary heart disease (CHD) and stroke risks were calculated for each patient using the UKPDS risk engine. Carotid intima media thickness (CIMT), flow mediated dilation (FMD), pulse wave velocity (PWV) and augmentation index (AI) were measured. The correlations between the UKPDS risk engine and the non-invasive vascular tests were assessed using partial correlation analysis, after adjusting for age, and multiple regression analysis.

Results

The mean 10-year CHD and 10-year stroke risks were 14.92±11.53% and 4.03±3.95%, respectively. The 10-year CHD risk correlated with CIMT (P<0.001), FMD (P=0.017), and PWV (P=0.35) after adjusting for age. The 10-year stroke risk correlated only with the mean CIMT (P<0.001) after adjusting for age. FMD correlated with age (P<0.01) and systolic blood pressure (P=0.09). CIMT correlated with age (P<0.01), HbA1c (P=0.05), and gender (P<0.01).

Conclusion

The CVD risk is increased at the onset of type 2 diabetes. CIMT, FMD, and PWV along with the UKPDS risk engine should be considered to evaluate cardiovascular disease risk in patients with newly diagnosed type 2 diabetes.

Citations

Citations to this article as recorded by

Association of cardiovascular risk estimate with degree of atherosclerosis in patients with type 2 diabetes mellitus
Mashkura Riyazuddeen, AliHasan Faiz Karnam, L Gopinath, Nayyar Iqbal
Journal of Current Research in Scientific Medicine.2019; 5(2): 94. CrossRef
Carotid atherosclerosis and its relationship to coronary heart disease and stroke risk in patients with type 2 diabetes mellitus
Yan Wu, Jie He, Xue Sun, Yi-Ming Zhao, Han-Yu Lou, Xiao-li Ji, Xiao-Hong Pang, Li-Zhen Shan, Ying-Xiu Kang, Jun Xu, Song-Zhao Zhang, Yong-Jian Wang, Yue-Zhong Ren, Peng-Fei Shan
Medicine.2017; 96(39): e8151. CrossRef
Diabetes Associated to Atherosclerosis Risk Factors in Patients of Family Health Unity
Polyane Medeiros Alves, Raiane dos Santos Pereira, Ariel Gustavo Letti, Álvaro Luís Müller da Fonseca
Open Journal of Preventive Medicine.2015; 05(04): 177. CrossRef
Independent Association of Circulating Level of Chemerin With Functional and Early Morphological Vascular Changes in Newly Diagnosed Type 2 Diabetic Patients
Bin Lu, Ming Zhao, Weimin Jiang, Jian Ma, Cuihua Yang, Jiaqing Shao, Ping Gu
Medicine.2015; 94(47): e1990. CrossRef
Assessment of Cardiovascular Risk in Adults With Type 2 Diabetes and Metabolic Syndrome
Chun-Ja Kim, Hee Sun Kang, Elizabeth A. Schlenk, Sun-Mi Chae
The Diabetes Educator.2015; 41(2): 203. CrossRef
Urinary adiponectin concentration is positively associated with micro- and macro-vascular complications
Won Seon Jeon, Ji Woo Park, Namseok Lee, Se Eun Park, Eun Jung Rhee, Won Young Lee, Ki Won Oh, Sung Woo Park, Cheol-Young Park, Byung-Soo Youn
Cardiovascular Diabetology.2013;[Epub] CrossRef
Development and a Pilot Test of an Internet-Based Cardiovascular Risk Reduction Program for Korean Male Workers With Metabolic Syndrome
CHUN-JA KIM, SEWON KANG
CIN: Computers, Informatics, Nursing.2013; 31(4): 157. CrossRef
Risk Factors for the Progression of Intima-Media Thickness of Carotid Arteries: A 2-Year Follow-Up Study in Patients with Newly Diagnosed Type 2 Diabetes
Sang Ouk Chin, Jin Kyung Hwang, Sang Youl Rhee, Suk Chon, You-Cheol Hwang, Seungjoon Oh, Kyu Jeung Ahn, Ho Yeon Chung, Jeong-taek Woo, Sung-Woon Kim, Young Seol Kim, Ja-Heon Kang, In-Kyung Jeong
Diabetes & Metabolism Journal.2013; 37(5): 365. CrossRef
Epicardial adipose tissue thickness is an indicator for coronary artery stenosis in asymptomatic type 2 diabetic patients: its assessment by cardiac magnetic resonance
Hyun Kim, Kwang Kim, Hye-Jeong Lee, Hee Yu, Jae Moon, Eun Kang, Bong Cha, Hyun Lee, Byung-Wan Lee, Young Kim
Cardiovascular Diabetology.2012; 11(1): 83. CrossRef
Potential association between coronary artery disease and the inflammatory biomarker YKL-40 in asymptomatic patients with type 2 diabetes mellitus
Hyun Min Kim, Byung-Wan Lee, Young-Mi Song, Won Jin Kim, Hyuk-Jae Chang, Dong-Hoon Choi, Hee Tae Yu, EunSeok Kang, Bong Soo Cha, Hyun Chul Lee
Cardiovascular Diabetology.2012;[Epub] CrossRef

Effects of Aerobic Exercise vs. Resistance Training on Endothelial Function in Women with Type 2 Diabetes Mellitus: Hwi Ryun Kwon, Kyung Wan Min, Hee Jung Ahn, Hee Geum Seok, Jae Hyuk Lee, Gang Seo Park, Kyung Ah Han; Diabetes Metab J. 2011;35(4):364-373. Published online August 31, 2011; DOI: https://doi.org/10.4093/dmj.2011.35.4.364

8,317 View
115 Download
69 Crossref

Abstract PDF PubReader

Background

There is controversy over whether aerobic or resistance exercise is more effective for improving endothelial function in type 2 diabetes mellitus (T2DM). This study was aimed to investigate the effects of an aerobic and resistance training program on endothelial function, and the influences of glycemic control, body weight changes, and aerobic capacity in T2DM.

Methods

Total 40 overweight women with T2DM were assigned into 3 groups: an aerobic exercise group (AEG, n=13), resistance exercise group (REG, n=12), and control group (CG, n=15), and followed either brisk walking for the AEG or resistance band training for the REG, 60 minutes per day, 5 days per week for 12 weeks with monitoring daily activity using accelerometers. We assessed endothelial function by flow-mediated dilation (FMD), and aerobic capacity by oxygen uptake at anaerobic threshold (AT_VO₂) at baseline and following training program.

Results

The mean participants' age was 57.0±6.8 years, and body mass index (BMI) was 27.0±2.3 kg/m². After intervention, FMD increased by 2.2±1.9% in AEG, which differed from REG and CG (P=0.002), despite of decreased body weight (BW) in both AG and RG (2.8±2.5%, P=0.002; 1.6±2.0%, P=0.017, respectively). A significant increased AT_VO₂ and decreased HbA1c were found only in AEG. In all participants, FMD was changed with the significant relations to the AT_VO₂ (r=0.348, P=0.035), but not to HbA1c levels or BW.

Conclusion

Aerobic exercise appears to be more beneficial than resistance exercise for improving endothelial function in T2DM. In addition, aerobic capacity could be a better predictor of changes in FMD than BW and glycemic control.

Citations

Citations to this article as recorded by

Influence of different exercise types on vascular endothelial function in middle-aged and older adults – A systematic review and network meta-analysis
Qin Chen, Xin Gao, Chen Wang, Peizhen Zhang
Archives of Gerontology and Geriatrics.2025; 128: 105624. CrossRef
Optimal strategies for exercise intervention in older people diabetic patients: The impacts of intensity, form, and frequency on glycemic control
Xueru Yan, Yujuan Lu, Haoda Zhang, Chen Zhu, Lan Tian, Jishuai Chen, Enpeng He, Yingying Li
Archives of Gerontology and Geriatrics.2025; 128: 105621. CrossRef
The effect of exercise on flow-mediated dilation in people with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials
Bopeng Qiu, Yilun Zhou, Xifeng Tao, Xiao Hou, Liwen Du, Yuanyuan Lv, Laikang Yu
Frontiers in Endocrinology.2024;[Epub] CrossRef
The Impact of Resistance Exercise Training on Glycemic Control Among Adults with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Yuwen Wan, Zhanguo Su
Biological Research For Nursing.2024; 26(4): 597. CrossRef
The effects of resistance training on cardiovascular factors and anti-inflammation in diabetic rats
Jin Yoo, Jinsu Hwang, Jiyun Choi, Mahesh Ramalingam, Haewon Jeong, Sujeong Jang, Han-Seong Jeong, Daeyeol Kim
Heliyon.2024; 10(17): e37081. CrossRef
Protocol for a randomized controlled trial of moderate intensity interval training in individuals with chronic obstructive pulmonary disease and obstructive sleep apnea overlap syndrome who have excessive daytime sleepiness
Madalina Macrea, Richard Casaburi, Richard ZuWallack, Atul Malhotra, Kris Ann Oursler
Contemporary Clinical Trials.2024; 145: 107663. CrossRef
A systematic review and meta‐analysis on effect of different exercise training on grip strength and upper extremity muscle strength in patients with type 2 diabetes mellitus
Mamta Boora, Manoj Malik, Jaspreet Kaur
Physiotherapy Research International.2024;[Epub] CrossRef
The Impact of Various Types of Exercise on Lipid Metabolism in Patients with Type 2 Diabetes and Concurrent Overweight/Obesity: A Narrative Review
Sameer Badri Al-mhanna, Wan Syaheedah Wan Ghazali, Alexios Batrakoulis, Nouf H. Alkhamees, Clemens Drenowatz, Mahaneem Mohamed, Mehmet Gülü, Hafeez Abiola Afolabi, Georgian Badicu
Annals of Applied Sport Science.2024;[Epub] CrossRef
Effects of resistance training on cardiovascular risk factors in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials
Yan Sun, Mingwei Sun, Xia Zeng, Liojuan Xiang Je, Zhannguo Su Guo
Acta Diabetologica.2024;[Epub] CrossRef
Low-Intensity Resistance Training Improves Flow-Mediated Dilation in Young Hispanic Adults
José M. Briceño-Torres, Elizabeth Carpio-Rivera, Andrea Solera-Herrera, Jeffrey Forsse, Peter W. Grandjean, José Moncada-Jiménez
Journal of Strength and Conditioning Research.2023; 37(2): 298. CrossRef
Intensity Differences of Resistance Training for Type 2 Diabetic Patients: A Systematic Review and Meta-Analysis
Tenglong Fan, Man-Hsu Lin, Kijin Kim
Healthcare.2023; 11(3): 440. CrossRef
Effect of continuous aerobic exercise on endothelial function: A systematic review and meta-analysis of randomized controlled trials
Xifeng Tao, Yiyan Chen, Kai Zhen, Shiqi Ren, Yuanyuan Lv, Laikang Yu
Frontiers in Physiology.2023;[Epub] CrossRef
Original article – Effect of different resistance training intensities on endothelial function in people with type 2 diabetes mellitus: A systematic review
Thiago Borges Madureira Sabino, Denise Maria Martins Vancea, Manoel da Cunha Costa, Raphael José Perrier de Melo, Iago Vilela Dantas, Jonathan Nicolas dos Santos Ribeiro
Diabetes Research and Clinical Practice.2023; 200: 110676. CrossRef
장기간의 저항성 트레이닝이 전문 보디빌더의 중심 동맥 혈압 및 경직도에 미치는 영향
동현 이, 원일 박, 재성 이, 형진 백, 광석 홍
The Korean Journal of Physical Education.2023; 62(4): 1. CrossRef
Dose-response relationships of resistance training in Type 2 diabetes mellitus: a meta-analysis of randomized controlled trials
Wanying Su, Meiyi Tao, Lin Ma, Ke Tang, Fang Xiong, Xuan Dai, Yuelan Qin
Frontiers in Endocrinology.2023;[Epub] CrossRef
Insight into type 2 diabetes impaired exercising mitochondrial oxidative flux: is it blood flow, mitochondria, or neither?
Noah A. John, Liam T. O'Brien
The Journal of Physiology.2022; 600(4): 707. CrossRef
Does exercise training improve the function of vascular smooth muscle? A systematic review and meta-analysis
Yujia Liu, Zhenjia Sun, Tong Chen, Chen Yang
Research in Sports Medicine.2022; 30(6): 577. CrossRef
Effect of resistance training on HbA1c in adults with type 2 diabetes mellitus and the moderating effect of changes in muscular strength: a systematic review and meta-analysis
Anna K Jansson, Li X Chan, David R Lubans, Mitch J Duncan, Ronald C Plotnikoff
BMJ Open Diabetes Research & Care.2022; 10(2): e002595. CrossRef
Does Aerobic plus Machine-Assisted Resistance Training Improve Vascular Function in Type 2 Diabetes? A Systematic Review and Meta-Analysis of Randomized Controlled Trials with Trial Sequential Analysis
Xianshan Guo, Shizhe Guo, Hongmei Zhang, Zhen Li
Journal of Clinical Medicine.2022; 11(15): 4257. CrossRef
Endurance Training Depletes Antioxidant System but Does Not Affect Endothelial Functions in Women with Abdominal Obesity: A Randomized Trial with a Comparison to Endurance-Strength Training
Małgorzata Jamka, Paweł Bogdański, Patrycja Krzyżanowska-Jankowska, Anna Miśkiewicz-Chotnicka, Joanna Karolkiewicz, Monika Duś-Żuchowska, Radosław Mądry, Aleksandra Lisowska, Anna Gotz-Więckowska, Saule Iskakova, Jarosław Walkowiak, Edyta Mądry
Journal of Clinical Medicine.2021; 10(8): 1639. CrossRef
The Role of Physical Therapy in the Combined Treatment of Patients with Lower Extremities Diabetic Angiopathies
Denis V. Frolov
Bulletin of Rehabilitation Medicine.2021; 20(2): 80. CrossRef
Low-to-Moderate-Intensity Resistance Exercise Is More Effective than High-Intensity at Improving Endothelial Function in Adults: A Systematic Review and Meta-Analysis
Yong Zhang, Ya-Jun Zhang, Hong-Wei Zhang, Wei-Bing Ye, Mallikarjuna Korivi
International Journal of Environmental Research and Public Health.2021; 18(13): 6723. CrossRef
Effects of resistance training on endothelial function: A systematic review and meta-analysis
Jessika Karla T.N.F. Silva, Annelise L. Menêses, Belinda J. Parmenter, Raphael M. Ritti-Dias, Breno Q. Farah
Atherosclerosis.2021; 333: 91. CrossRef
Vascular Ageing and Aerobic Exercise
Michaela Kozakova, Carlo Palombo
International Journal of Environmental Research and Public Health.2021; 18(20): 10666. CrossRef
High-Intensity Endurance and Strength Training in Water Polo Olympic Team Players: Impact on Arterial Wall Properties
Evangelos Oikonomou, Gerasimos Siasos, Georgios Marinos, Marina Zaromitidou, Dimitris Athanasiou, Petros Fountoulakis, Sotiris Tsalamandris, Georgios Charalambous, Georgios Lazaros, Charalambos Vlachopoulos, Dimitris Tousoulis
Cardiology.2021; 146(1): 119. CrossRef
Beyond general resistance training. Hypertrophy versus muscular endurance training as therapeutic interventions in adults with type 2 diabetes mellitus: A systematic review and meta‐analysis
Pedro Acosta‐Manzano, María Rodriguez‐Ayllon, Francisco M. Acosta, David Niederseer, Josef Niebauer
Obesity Reviews.2020;[Epub] CrossRef
Aerobic Exercise Increases Tear Secretion and Decreases Inflammatory Cytokines in Healthy Subjects
Hao Li, Fei Li, Rouxi Zhou, Kai Gao, Lingyi Liang, Xiulan Zhang
Asia-Pacific Journal of Ophthalmology.2020; 9(5): 404. CrossRef
The Role of Aerobic Training Variables Progression on Glycemic Control of Patients with Type 2 Diabetes: a Systematic Review with Meta-analysis
Rodrigo Sudatti Delevatti, Cláudia Gomes Bracht, Salime Donida Chedid Lisboa, Rochelle Rocha Costa, Elisa Corrêa Marson, Nathalie Netto, Luiz Fernando Martins Kruel
Sports Medicine - Open.2019;[Epub] CrossRef
Effect of Exercise on Risk Factors of Diabetic Foot Ulcers
Fuyuan Liao, Ruopeng An, Fang Pu, Stephanie Burns, Sa Shen, Yih-Kuen Jan
American Journal of Physical Medicine & Rehabilitation.2019; 98(2): 103. CrossRef
Therapeutic Options Targeting Oxidative Stress, Mitochondrial Dysfunction and Inflammation to Hinder the Progression of Vascular Complications of Diabetes
João S. Teodoro, Sara Nunes, Anabela P. Rolo, Flávio Reis, Carlos M. Palmeira
Frontiers in Physiology.2019;[Epub] CrossRef
Effects of short-term resistance training on endothelial function and inflammation markers in elderly patients with type 2 diabetes: A randomized controlled trial
Anderson Rech, Cíntia Ehlers Botton, Pedro Lopez, André Quincozes-Santos, Daniel Umpierre, Ronei Silveira Pinto
Experimental Gerontology.2019; 118: 19. CrossRef
Resistance Exercise Intensity is Correlated with Attenuation of HbA1c and Insulin in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis
Yubo Liu, Weibing Ye, Qian Chen, Yong Zhang, Chia-Hua Kuo, Mallikarjuna Korivi
International Journal of Environmental Research and Public Health.2019; 16(1): 140. CrossRef
Effects of Resistance Exercise on Glycated Hemoglobin and Functional Performance in Older Patients with Comorbid Diabetes Mellitus and Knee Osteoarthritis: A Randomized Trial
Shu-Mei Chen, Feng-Chih Shen, Jung-Fu Chen, Wen-Dien Chang, Nai-Jen Chang
International Journal of Environmental Research and Public Health.2019; 17(1): 224. CrossRef
Endothelial function following interval exercise plus low‐calorie diet treatment in obese females
Nicole M. Gilbertson, Stephanie L. Miller, Natalie Z.M. Eichner, Steven K. Malin
Physiological Reports.2019;[Epub] CrossRef
The effects of exercise on vascular endothelial function in type 2 diabetes: a systematic review and meta-analysis
Jung-Hoon Lee, Ruda Lee, Moon-Hyon Hwang, Marc T. Hamilton, Yoonjung Park
Diabetology & Metabolic Syndrome.2018;[Epub] CrossRef
Exercise training and endothelial function in patients with type 2 diabetes: a meta-analysis
Shanhu Qiu, Xue Cai, Han Yin, Zilin Sun, Martina Zügel, Jürgen Michael Steinacker, Uwe Schumann
Cardiovascular Diabetology.2018;[Epub] CrossRef
Responses of healthy young males to fine-particle exposure are modified by exercise habits: a panel study
Xi Chen, Wu Chen, Yanwen Wang, Yiqun Han, Tong Zhu
Environmental Health.2018;[Epub] CrossRef
Aerobic exercise regulates blood lipid and insulin resistance via the toll‑like receptor 4‑mediated extracellular signal‑regulated kinases/AMP‑activated protein kinases signaling pathway
Mei Wang, Sen Li, Fubaihui Wang, Jinhui Zou, Yanfeng Zhang
Molecular Medicine Reports.2018;[Epub] CrossRef
Efectos del ejercicio físico en los factores de riesgo cardiovascular que constituyen el síndrome metabólico: una alternativa para reducir su tendencia
Adrián Hernández Alonso
Revista Colombiana de Médicina Física y Rehabilitación.2017; 27(2): 140. CrossRef
Anti-inflammatory effects of active commuting and leisure time exercise in overweight and obese women and men: A randomized controlled trial
Anne Sofie Gram, Else-Marie Bladbjerg, Jonas Salling Quist, Martin Bæk Petersen, Mads Rosenkilde, Bente Stallknecht
Atherosclerosis.2017; 265: 318. CrossRef
The Effects of Exercise Training on Brachial Artery Flow-Mediated Dilation
Kate S. Early, Abigail Stewart, Neil Johannsen, Carl J. Lavie, Jerry R. Thomas, Michael Welsch
Journal of Cardiopulmonary Rehabilitation and Prevention.2017; 37(2): 77. CrossRef
Effects of Self-directed Exercise Programmes on Individuals with Type 2 Diabetes Mellitus: A Systematic Review Evaluating Their Effect on HbA1c and Other Metabolic Outcomes, Physical Characteristics, Cardiorespiratory Fitness and Functional Outcomes
Hugh Byrne, Brian Caulfield, Giuseppe De Vito
Sports Medicine.2017; 47(4): 717. CrossRef
Effects of Combination of Baduanjin and Elastic Band on Physical Fitness and Glycemic Control in Patients with Type 2 Diabetes Mellitus
强庄
Advances in Physical Sciences.2017; 05(01): 5. CrossRef
Effects of progressive resistance training and weight loss versus weight loss alone on inflammatory and endothelial biomarkers in older adults with type 2 diabetes
Eliza G. Miller, Parneet Sethi, Caryl A. Nowson, David W. Dunstan, Robin M. Daly
European Journal of Applied Physiology.2017; 117(8): 1669. CrossRef
Endurance exercise per se reduces the cardiovascular risk marker t-PA antigen in healthy, younger, overweight men
Else-Marie Bladbjerg, Jane Skov, Pernille Nordby, Bente Stallknecht
Thrombosis Research.2017; 152: 69. CrossRef
Effect of Exercise Intervention on Flow-Mediated Dilation in Overweight and Obese Adults: Meta-Analysis
Younsun Son, Kyungun Kim, Soeun Jeon, Minsoo Kang, Sukho Lee, Yoonjung Park
International Journal of Vascular Medicine.2017; 2017: 1. CrossRef
Effects of Elastic Band Resistance Training on Glucose Control, Body Composition, and Physical Function in Women With Short- vs. Long-Duration Type-2 Diabetes
Bong-Sup Park, Andy V. Khamoui, Lee E. Brown, Do-Youn Kim, Kyung-Ah Han, Kyung-Wan Min, Geun-Hee An
Journal of Strength and Conditioning Research.2016; 30(6): 1688. CrossRef
Glycemic reductions following water- and land-based exercise in patients with type 2 diabetes mellitus
Rodrigo Sudatti Delevatti, Carolina Dertzbocher Feil Pinho, Ana Carolina Kanitz, Cristine Lima Alberton, Elisa Corrêa Marson, Luciana Peruchena Bregagnol, Salime Chedid Lisboa, Beatriz D. Schaan, Luiz Fernando Martins Kruel
Complementary Therapies in Clinical Practice.2016; 24: 73. CrossRef
Short-term exercise training improves flow-mediated dilation and circulating angiogenic cell number in older sedentary adults
Rian Q. Landers-Ramos, Kelsey J. Corrigan, Lisa M. Guth, Christine N. Altom, Espen E. Spangenburg, Steven J. Prior, James M. Hagberg
Applied Physiology, Nutrition, and Metabolism.2016; 41(8): 832. CrossRef
Glucose control can be similarly improved after aquatic or dry-land aerobic training in patients with type 2 diabetes: A randomized clinical trial
Rodrigo S. Delevatti, Ana Carolina Kanitz, Cristine L. Alberton, Elisa Corrêa Marson, Salime Chedid Lisboa, Carolina Dertzbocher Feil Pinho, Gisele A. Lovatel, Arthiese Korb, Karine Bertoldi, Rodrigo C.O. Macedo, Ionara R. Siqueira, Beatriz D. Schaan, Lui
Journal of Science and Medicine in Sport.2016; 19(8): 688. CrossRef
Assessment of endothelial function by flow-mediated dilation in diabetic patients: Effects of physical exercise
Aline P Jarrete, Angelina Zanesco, Maria Andréia Delbin
Motriz: Revista de Educação Física.2016; 22(1): 3. CrossRef
Psychosocial Variables Related to Why Women are Less Active than Men and Related Health Implications
Elizabeth Skidmore Edwards, Sarah Carson Sackett
Clinical Medicine Insights: Women's Health.2016; 9s1: CMWH.S34668. CrossRef
In Search of the Ideal Resistance Training Program to Improve Glycemic Control and its Indication for Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis
Hajime Ishiguro, Satoru Kodama, Chika Horikawa, Kazuya Fujihara, Ayumi Sugawara Hirose, Reiko Hirasawa, Yoko Yachi, Nobumasa Ohara, Hitoshi Shimano, Osamu Hanyu, Hirohito Sone
Sports Medicine.2016; 46(1): 67. CrossRef
Effects of exercise training using resistance bands on glycaemic control and strength in type 2 diabetes mellitus: a meta-analysis of randomised controlled trials
Samantha K. McGinley, Marni J. Armstrong, Normand G. Boulé, Ronald J. Sigal
Acta Diabetologica.2015; 52(2): 221. CrossRef
Impact of combined exercise training on cardiovascular autonomic control and mortality in diabetic ovariectomized rats
Iris C. Sanches, Filipe F. Conti, Nathalia Bernardes, Janaina de O Brito, Elia G. Galdini, Cláudia R. Cavaglieri, Maria-Cláudia Irigoyen, Kátia De Angelis
Journal of Applied Physiology.2015; 119(6): 656. CrossRef
Three months of strictly controlled daily endurance exercise reduces thrombin generation and fibrinolytic risk markers in younger moderately overweight men
Anne Sofie Gram, Else-Marie Bladbjerg, Jane Skov, Thorkil Ploug, Anders Sjödin, Mads Rosenkilde, Daniel Elenius Madsen, Bente Merete Stallknecht
European Journal of Applied Physiology.2015; 115(6): 1331. CrossRef
Exercise Modalities and Endothelial Function: A Systematic Review and Dose–Response Meta-Analysis of Randomized Controlled Trials
Ammar W. Ashor, Jose Lara, Mario Siervo, Carlos Celis-Morales, Clio Oggioni, Djordje G. Jakovljevic, John C. Mathers
Sports Medicine.2015; 45(2): 279. CrossRef
The Impact of High-Intensity Interval Training Versus Moderate-Intensity Continuous Training on Vascular Function: a Systematic Review and Meta-Analysis
Joyce S. Ramos, Lance C. Dalleck, Arnt Erik Tjonna, Kassia S. Beetham, Jeff S. Coombes
Sports Medicine.2015; 45(5): 679. CrossRef
Safety of Aerobic Exercise in People With Diabetic Peripheral Neuropathy: Single-Group Clinical Trial
Patricia M. Kluding, Mamatha Pasnoor, Rupali Singh, Linda J. D'Silva, Min Yoo, Sandra A. Billinger, Joseph W. LeMaster, Mazen M. Dimachkie, Laura Herbelin, Douglas E. Wright
Physical Therapy.2015; 95(2): 223. CrossRef
Sleep and exercise: A reciprocal issue?
Mounir Chennaoui, Pierrick J. Arnal, Fabien Sauvet, Damien Léger
Sleep Medicine Reviews.2015; 20: 59. CrossRef
Blood glucose response to aerobic exercise training program among patients with type 2 diabetes mellitus at the University of Nigeria Teaching Hospital, Enugu South-East, Nigeria
C. I. Ezema, S. Lamina, Amarachi A. Onwunali, U. A. Ezugwu, A. A. Amaeze, M. J. Nwankwo
International Journal of Diabetes in Developing Countries.2015; 35(S2): 88. CrossRef
Endothelial Function Increases after a 16-Week Diet and Exercise Intervention in Overweight and Obese Young Women
Lisa M. Cotie, Andrea R. Josse, Stuart M. Phillips, Maureen J. MacDonald
BioMed Research International.2014; 2014: 1. CrossRef
Impact of different training modalities on glycaemic control and blood lipids in patients with type 2 diabetes: a systematic review and network meta-analysis
Lukas Schwingshackl, Benjamin Missbach, Sofia Dias, Jürgen König, Georg Hoffmann
Diabetologia.2014; 57(9): 1789. CrossRef
Exercise as a Therapeutic Strategy for Primary Mitochondrial Cytopathies
Mark A. Tarnopolsky
Journal of Child Neurology.2014; 29(9): 1225. CrossRef
Effects of weight management by exercise modes on markers of subclinical atherosclerosis and cardiometabolic profile among women with abdominal obesity: a randomized controlled trial
Jina Choo, Juneyoung Lee, Jeong-Hyun Cho, Lora E Burke, Akira Sekikawa, Sae Young Jae
BMC Cardiovascular Disorders.2014;[Epub] CrossRef
Walking disability in patients with peripheral artery disease is associated with arterial endothelial function
S. Marlene Grenon, Karen Chong, Hugh Alley, Emily Nosova, Warren Gasper, Jade Hiramoto, W. John Boscardin, Christopher D. Owens
Journal of Vascular Surgery.2014; 59(4): 1025. CrossRef
Cardiovascular Function and Predictors of Exercise Capacity in Patients With Colorectal Cancer
Larissa Cramer, Bert Hildebrandt, Thomas Kung, Kristin Wichmann, Jochen Springer, Wolfram Doehner, Anja Sandek, Miroslava Valentova, Tatjana Stojakovic, Hubert Scharnagl, Hanno Riess, Stefan D. Anker, Stephan von Haehling
Journal of the American College of Cardiology.2014; 64(13): 1310. CrossRef
Effects of Exercise Training on Arterial Function in Type 2 Diabetes Mellitus
David Montero, Guillaume Walther, Eric Benamo, Antonia Perez-Martin, Agnès Vinet
Sports Medicine.2013; 43(11): 1191. CrossRef
A randomized trial of exercise for blood pressure reduction in type 2 diabetes: Effect on flow-mediated dilation and circulating biomarkers of endothelial function
Bethany Barone Gibbs, Devon A. Dobrosielski, Susanne Bonekamp, Kerry J. Stewart, Jeanne M. Clark
Atherosclerosis.2012; 224(2): 446. CrossRef

The Correlations between Extremity Circumferences with Total and Regional Amounts of Skeletal Muscle and Muscle Strength in Obese Women with Type 2 Diabetes: Hwi Ryun Kwon, Kyung Ah Han, Hee Jung Ahn, Jae Hyuk Lee, Gang Seo Park, Kyung Wan Min; Diabetes Metab J. 2011;35(4):374-383. Published online August 31, 2011; DOI: https://doi.org/10.4093/dmj.2011.35.4.374

5,324 View
47 Download
14 Crossref

Abstract PDF PubReader

Background

Insulin resistance is related to central obesity and the amount of skeletal muscle. A simple and practical anthropometric marker for muscle mass is not known, although waist circumference (WC) is used as an indicator of abdominal obesity. The aims of this study were to investigate whether arm (AC) and thigh circumferences (TC) can be used as an indicator of muscle mass and if they are related to muscle strength.

Methods

A total of 110 obese (body mass index [BMI]≥25 kg/m²) women with type 2 diabetes were enrolled, and WC, AC, and TC were measured. Abdominal visceral fat (AVF), subcutaneous fat (ASF), and total fat (ATF) were assessed by computed tomography, regional muscle (MM), and fat mass by dual-energy X-ray absorptiometry, muscle strength by one repetition maximum (1RM) of both extremities (chest and leg press) and insulin resistance by K_ITT.

Results

The mean age was 56.2±7.3 years, duration of diabetes was 4.2±4.4 years, and BMI was 27.2±2.8 kg/m². WC was correlated with ATF, AVF, and ASF (r=0.728, P<0.001; r=0.515, P<0.001; r=0.608, P<0.001, respectively). Arm MM was correlated with AC (r=0.500, P<0.001), and leg MM with TC (r=0.291, P=0.002). Upper 1RM was related to AC/WC ratio (r=0.359, P<0.001), and lower 1RM was to TC/WC ratio (r=0.286, P=0.003). Insulin resistance had significant relations with AVF, WC, and total MM (r=-0.262, P=0.008; r=-0.217, P=0.029; r=0.160, P=0.031, respectively).

Conclusion

The muscle mass was related to extremity circumferences, and muscle strength was to extremity/waist circumference ratio in obese women with type 2 diabetes.

Citations

Citations to this article as recorded by

Inflammation and Loss of Skeletal Muscle Mass in Chronic Limb Threatening Ischemia
Joana Ferreira, Alexandre Carneiro, Isabel Vila, Cristina Silva, Cristina Cunha, Adhemar Longatto-Filho, Amílcar Mesquita, Jorge Cotter, Armando Mansilha, Margarida Correia-Neves, Pedro Cunha
Annals of Vascular Surgery.2023; 88: 164. CrossRef
Thigh-hip ratio is significantly associated with all-cause mortality among Japanese community-dwelling men
Ryuichi Kawamoto, Asuka Kikuchi, Daisuke Ninomiya, Teru Kumagi, Fredirick Lazaro mashili
PLOS ONE.2023; 18(10): e0292287. CrossRef
Association of Skeletal Muscle and Cardiovascular Risk Factors in Patients with Lower Extremity Arterial Disease
Joana Ferreira, Alexandre Lima Carneiro, Isabel Vila, Cristina Cunha, C ristina Silva, Adhemar Longatto-Filho, Amesqui Mesquita, Jorge Cotter, Armando Mansilha, Margarida Correia-Neves, Pedro Cunha
Annals of Vascular Surgery.2022; 80: 223. CrossRef
A randomized, double-blind, placebo-controlled trial to evaluate the hypoglycemic efficacy of the mcIRBP-19-containing Momordica charantia L. fruit extracts in the type 2 diabetic subjects
Yi-Sun Yang, Nian-Yi Wu, Edy Kornelius, Chien-Ning Huang, Nae-Cherng Yang
Food & Nutrition Research.2022;[Epub] CrossRef
Thigh circumference and handgrip strength are significantly associated with all-cause mortality: findings from a study on Japanese community-dwelling persons
Ryuichi Kawamoto, Asuka Kikuchi, Taichi Akase, Daisuke Ninomiya, Teru Kumagi
European Geriatric Medicine.2021; 12(6): 1191. CrossRef
Thigh Circumference and Risk of All-Cause, Cardiovascular and Cerebrovascular Mortality: A Cohort Study

Chao-lei Chen, Lin Liu, Jia-yi Huang, Yu-ling Yu, Geng Shen, Kenneth Lo, Yu-qing Huang, Ying-qing Feng
Risk Management and Healthcare Policy.2020; Volume 13: 1977. CrossRef
Mid-arm muscle circumference as an indicator of osteoporosis in community-dwelling older men
Yuan-Ping Chao, Tung-Wei Kao, Wei-Liang Chen, Tao-Chun Peng, Li-Wei Wu
Archives of Gerontology and Geriatrics.2020; 87: 103998. CrossRef
Carnitine deficiency is associated with decreased exercise activity in hemodialysis patients
Junko Yano, Yusuke Kaida, Yosuke Nakayama, Sakuya Ito, Yuka Kurokawa, Nao Nakamura, Takuma Hazama, Takashi Maeda, Ryuki Hashida, Kyoko Tashiro, Takahiro Inokuchi, Hiroo Matsuse, Kei Fukami
Renal Replacement Therapy.2019;[Epub] CrossRef
Preliminary study of the anabolic/catabolic balance in patients with interstitial pulmonary fibrosis
Ahmed El Hosainy, Safy Kaddah, Mohamed Saied, Aml Ibrahim, Rania Darwish
Egyptian Journal of Chest Diseases and Tuberculosis.2017; 66(3): 497. CrossRef
Anthropometric dimensions provide reliable estimates of abdominal adiposity: A validation study
Z. Pintér, A. Pósa, C. Varga, I. Horváth, A. Palkó, Z. Just, G. Pálfi
HOMO.2017; 68(5): 398. CrossRef
Creatine kinase in the U.S. population
Michael D. George, Neilia-Kay McGill, Joshua F. Baker
Medicine.2016; 95(33): e4344. CrossRef
Relationship of calf circumference with bone mineral density and hip geometry: a hospital-based cross-sectional study
Rekha Singh, Sushil Gupta
Archives of Osteoporosis.2015;[Epub] CrossRef
Acupuncture for Management of Balance Impairment in a Patient with Bipolar Disorder
Kun Hyung Kim, Jae Kyu Kim, Gi Young Yang, Byung Ryul Lee, Seung Hee Noh
Journal of Acupuncture and Meridian Studies.2013; 6(1): 56. CrossRef
The association of insulin resistance and carotid atherosclerosis with thigh and calf circumference in patients with type 2 diabetes
Jong Suk Park, Min Ho Cho, Chul Woo Ahn, Kyung Rae Kim, Kap Bum Huh
Cardiovascular Diabetology.2012;[Epub] CrossRef

Response: The Effect of an Angiotensin Receptor Blocker on Arterial Stiffness in Type 2 Diabetes Mellitus Patients with Hypertension (Diabetes Metab J 2011;35:236-42): Ji Hyun Kim, Su Jin Oh, Jung Min Lee, Eun Gyoung Hong, Jae Myung Yu, Kyung Ah Han, Kyung Wan Min, Hyun Shik Son, Sang Ah Chang; Diabetes Metab J. 2011;35(4):429-430. Published online August 31, 2011; DOI: https://doi.org/10.4093/dmj.2011.35.4.429

4,214 View
35 Download

PDF PubReader

The Effect of an Angiotensin Receptor Blocker on Arterial Stiffness in Type 2 Diabetes Mellitus Patients with Hypertension: Ji Hyun Kim, Su Jin Oh, Jung Min Lee, Eun Gyoung Hong, Jae Myung Yu, Kyung Ah Han, Kyung Wan Min, Hyun Shik Son, Sang Ah Chang; Diabetes Metab J. 2011;35(3):236-242. Published online June 30, 2011; DOI: https://doi.org/10.4093/dmj.2011.35.3.236

29,897 View
40 Download
7 Crossref

Abstract PDF PubReader

Background

Hypertension and type 2 diabetes mellitus are major risk factors for cardiovascular disease. This study analyzed the changes in central aortic waveforms and pulse wave velocity as well as related parameters after treatment with valsartan, an angiotensin II type 1 receptor blocker, in patients with type 2 diabetes and hypertension.

Methods

We used pulse wave analysis to measure central aortic waveform in a total of 98 subjects. In 47 of these patients, pulse wave velocity measurements were obtained before and after 12 weeks of treatment with valsartan.

Results

In the central aortic waveform analysis, the aortic pulse pressure and augmentation index were significantly decreased after valsartan treatment, as was the aortic pulse wave velocity. Factors contributing to the improvement in pulse wave velocity were the fasting blood glucose and haemoglobin A1c levels.

Conclusion

Short-term treatment with valsartan improves arterial stiffness in patients with type 2 diabetes and hypertension, and the glucose status at baseline was associated with this effect.

Citations

Citations to this article as recorded by

Mechanisms underlying the blood pressure‐lowering effects of empagliflozin, losartan and their combination in people with type 2 diabetes: A secondary analysis of a randomized crossover trial
Rosalie A. Scholtes, Charlotte M. Mosterd, Anne C. Hesp, Mark M. Smits, Hiddo J. L. Heerspink, Daniël H. van Raalte
Diabetes, Obesity and Metabolism.2023; 25(1): 198. CrossRef
Distinct effects of losartan and atenolol on vascular stiffness in Marfan syndrome
Ami B Bhatt, J Stewart Buck, Jonah P Zuflacht, Jessica Milian, Samoneh Kadivar, Kimberlee Gauvreau, Michael N Singh, Mark A Creager
Vascular Medicine.2015; 20(4): 317. CrossRef
The impact of angiotensin receptor blockers on arterial stiffness: a meta-analysis
Feng Peng, Hongming Pan, Bin Wang, Jinxiu Lin, Wenquan Niu
Hypertension Research.2015; 38(9): 613. CrossRef
Arterial stiffness in atherosclerotic renovascular hypertension
Ljiljana Fodor, Vedran Premužić, Vanja Ivković, Dražen Perkov, Mario Laganović, Tajana Željković Vrkić, Živka Dika, Marijana Živko, Bojan Jelaković
Journal of Hypertension.2014; 32(11): 2238. CrossRef
Improvement of arterial wall characteristics by the low-dose fluvastatin and valsartan combination in type 1 diabetes mellitus patients
Vedran Savić, Barbara Eržen, Miodrag Janić, Mojca Lunder, Maja Boncelj, Karin Kanc, Andrej Janež, Mišo Šabovič
Diabetes and Vascular Disease Research.2013; 10(5): 420. CrossRef
The association between regional arterial stiffness and diabetic retinopathy in type 2 diabetes
Won Jun Kim, Cheol-Young Park, Se Eun Park, Eun Jung Rhee, Won Young Lee, Ki Won Oh, Sung Woo Park, Sun Woo Kim, SuJeong Song
Atherosclerosis.2012; 225(1): 237. CrossRef
Letter: The Effect of an Angiotensin Receptor Blocker on Arterial Stiffness in Type 2 Diabetes Mellitus Patients with Hypertension (Diabetes Metab J 2011;35:236-42)
Chul-Hee Kim
Diabetes & Metabolism Journal.2011; 35(4): 427. CrossRef

Small Rice Bowl-Based Meal Plan for Energy and Marcronutrient Intake in Korean Men with Type 2 Diabetes: A Pilot Study: Hee Jung Ahn, Kyung Ah Han, Jin Young Jang, Jae Hyuk Lee, Kang Seo Park, Kyung Wan Min; Diabetes Metab J. 2011;35(3):273-281. Published online June 30, 2011; DOI: https://doi.org/10.4093/dmj.2011.35.3.273

65,535 View
40 Download
3 Crossref

Abstract PDF PubReader

Background

Koreans eat rice, which is usually served in a rice bowl. We investigated the effect of a meal plan using small rice bowls on the total energy intake (TEI) and the marcronutrient intake in Korean men with type 2 diabetes.

Methods

A total of 62 men with type 2 diabetes were divided by body mass index (BMI) (normal weight [NW], BMI<23 kg/m²; overweight [OW], 23≤BMI<25 kg/m²; obese [OB], BMI≥25 kg/m²) and proportions of carbohydrate intake to TEI (PCI) (low carbohydrate intake [LC], <55%; recommended carbohydrate intake [RC], ≥55% and ≤60%; high carbohydrate intake [HC], >60%). The 3-day dietary records were analyzed for TEI and proportions of macronutrients, before and 2 weeks after a small-sized (300 mL) rice bowl based education was given.

Results

There were no significant differences in the age and BMI within the sub-groups by BMI and PCI groups. In baseline, the ratio of TEI to recommended total energy intake (RTR) of OW and OB were higher than that of NW. The PCI of HC was higher than that of LC and alcohol intake of HC was lower than that of LC. After education, the reduction of RTREI in OB was higher than that in OW and NW. The reduction of PCI in HC was higher than that of LC.

Conclusion

A small rice bowl based meal plan was effective for the reduction of energy intake and control of marcronutrient intake in Korean obese men with type 2 diabetes consuming a high carbohydrate diet.

Citations

Citations to this article as recorded by

Comprehensive Understanding for Application in Korean Patients with Type 2 Diabetes Mellitus of the Consensus Statement on Carbohydrate-Restricted Diets by Korean Diabetes Association, Korean Society for the Study of Obesity, and Korean Society of Hyperte
Jong Han Choi, Jee-Hyun Kang, Suk Chon
Diabetes & Metabolism Journal.2022; 46(3): 377. CrossRef
The association between measurement sites of visceral adipose tissue and cardiovascular risk factors after caloric restriction in obese Korean women
Hye-Ok Lee, Jung-Eun Yim, Jeong-Sook Lee, Young-Seol Kim, Ryowon Choue
Nutrition Research and Practice.2013; 7(1): 43. CrossRef
Daily Rice Intake Strongly Influences the Incidence of Metabolic Syndrome in Japanese Men Aged 40-59 Years
Yoko Watanabe, Isao Saito, Yasuhiko Asada, Taro Kishida, Tatsuhiro Matsuo, Masamitsu Yamaizumi, Tadahiro Kato
Journal of Rural Medicine.2013; 8(1): 161. CrossRef

The Small Rice Bowl-Based Meal Plan was Effective at Reducing Dietary Energy Intake, Body Weight, and Blood Glucose Levels in Korean Women with Type 2 Diabetes Mellitus: Hee Jung Ahn, Kyung Ah Han, Hwi Ryun Kwon, Kyung Wan Min; Korean Diabetes J. 2010;34(6):340-349. Published online December 31, 2010; DOI: https://doi.org/10.4093/kdj.2010.34.6.340

3,977 View
41 Download
5 Crossref

Abstract PDF PubReader

Background

The typical Korean diet includes rice, which is usually served in a rice bowl. We investigated the effects of a meal plan using rice bowls of varying sizes on dietary energy intake (EI), body weight (BW), and blood glucose levels.

Methods

Forty-two obese women with type 2 diabetes mellitus were randomly assigned to use either a 200 mL small rice bowl (SB), a 380 mL regular rice bowl (RB), or to a control group (C). Both intervention groups were asked to reduce their EI by 500 kcal/day for 12 weeks and simple instructions for using the assigned bowl were provided. Dietary EI and proportion of macronutrients (PMN) were estimated from 3-day dietary records.

Results

Reduction of EI was more prominent in the SB group compared to the RB and C group, although EI decreased significantly from baseline in all groups. Carbohydrate and fat intakes of the SB group were decreased greater than those of the RB and C group. However, changes in PMN were not significant across the 3 groups. Reduction of BW and HbA1c levels in the SB group was more prominent compared to the C group. Although, BW and HbA1c were decreased significantly from baseline in both bowl groups. There was no statistical difference between the two groups.

Conclusion

The small rice bowl-based meal plan was effective at reducing EI, BW, and blood glucose levels, and the observed reductions in EI, carbohydrate, and fat intake were greater than those of the regular rice bowl-based meal plan.

Citations

Citations to this article as recorded by

Impact of Portion Control Tools on Portion Size Awareness, Choice and Intake: Systematic Review and Meta-Analysis
M. Angeles Vargas-Alvarez, Santiago Navas-Carretero, Luigi Palla, J. Alfredo Martínez, Eva Almiron-Roig
Nutrients.2021; 13(6): 1978. CrossRef
Do adults draw differently-sized meals on larger or smaller plates? Examining plate size in a community sample
David Sharp, Jeffery Sobal, Elaine Wethington
Food Quality and Preference.2019; 74: 72. CrossRef
Use and effectiveness of behavioural economics in interventions for lifestyle risk factors of non-communicable diseases: a systematic review with policy implications
Oana M Blaga, Livia Vasilescu, Razvan M Chereches
Perspectives in Public Health.2018; 138(2): 100. CrossRef
Whether Smaller Plates Reduce Consumption Depends on Who's Serving and Who's Looking: A Meta-Analysis
Stephen S. Holden, Natalina Zlatevska, Chris Dubelaar
SSRN Electronic Journal .2015;[Epub] CrossRef
Portion, package or tableware size for changing selection and consumption of food, alcohol and tobacco
Gareth J Hollands, Ian Shemilt, Theresa M Marteau, Susan A Jebb, Hannah B Lewis, Yinghui Wei, Julian P T Higgins, David Ogilvie
Cochrane Database of Systematic Reviews.2015;[Epub] CrossRef

The Usefulness of an Accelerometer for Monitoring Total Energy Expenditure and Its Clinical Application for Predicting Body Weight Changes in Type 2 Diabetic Korean Women: Ji Yeon Jung, Kyung Ah Han, Hwi Ryun Kwon, Hee Jung Ahn, Jae Hyuk Lee, Kang Seo Park, Kyung Wan Min; Korean Diabetes J. 2010;34(6):374-383. Published online December 31, 2010; DOI: https://doi.org/10.4093/kdj.2010.34.6.374

8,576 View
27 Download
1 Crossref

Abstract PDF PubReader

Background

The purpose of this study was to evaluate the usefulness of an accelerometer in predicting body weight (BW) change during a lifestyle intervention and to find out whether exercise or overall physical activity is associated with change in insulin sensitivity and body composition.

Methods

A total of 49 overweight (body mass index [BMI] ≥ 23 kg/m²) women with diabetes were enrolled and performed lifestyle intervention while monitoring BW, total energy expenditure (TEE) and physical activity energy expenditure (PAEE) using an accelerometer, and energy intake (EI) using a three-day dietary record at baseline and every 2 weeks for 12 weeks. We assessed body composition using bioimpedance analysis and compared the actual BW change to the predicted BW change, which was calculated from the energy deficit (ED) between EI and TEE (ED = EI-TEE).

Results

Mean age was 57.2 years, duration of diabetes was 8.0 years, and BMI was 27.8 kg/m². There was no significant difference between EI and TEE at baseline. For 12 weeks, the ED was 474.0 kcal·day^-1, which was significantly correlated with BW change (-3.1 kg) (r = 0.725, P < 0.001). However, the actual BW change was 50% lower than the predicted BW change. Both TEE and PAEE correlated with change in K_ITT (r = 0.334, P = 0.019; r = 0.358, P = 0.012, respectively), BMI (r = -0.395, P = 0.005; r = -0.347, P = 0.015, respectively), and fat mass (r = -0.383, P = 0.007; r = -0.395, P = 0.005, respectively), but only TEE correlated with fat free mass change (r = -0.314, P = 0.030).

Conclusion

The accelerometer appears to be a useful tool for measuring TEE under free-living conditions for both short- and long-term periods.

Citations

Citations to this article as recorded by

Whether Smaller Plates Reduce Consumption Depends on Who’s Serving and Who’s Looking: A Meta-Analysis
Stephen S. Holden, Natalina Zlatevska, Chris Dubelaar
Journal of the Association for Consumer Research.2016; 1(1): 134. CrossRef

The Effects of Resistance Training on Muscle and Body Fat Mass and Muscle Strength in Type 2 Diabetic Women: Hwi Ryun Kwon, Kyung Ah Han, Yun Hyi Ku, Hee Jung Ahn, Bo-Kyung Koo, Ho Chul Kim, Kyung Wan Min; Korean Diabetes J. 2010;34(2):101-110. Published online April 30, 2010; DOI: https://doi.org/10.4093/kdj.2010.34.2.101

6,414 View
91 Download
59 Crossref

Abstract PDF PubReader

Background

Our goal was to investigate the effects of low intensity resistance training on body fat, muscle mass and strength, cardiovascular fitness, and insulin sensitivity in type 2 diabetes.

Methods

Twenty-eight overweight women with type 2 diabetes were randomly assigned to a resistance training group (RG, n = 13) or a control group (CG, n = 15). RG performed resistance training using elastic bands, of which strength was equal to 40 to 50% of one repetition maximum (1RM), for three days per week. Each exercise consisted of three sets for 60 minutes. We assessed abdominal fat using computed tomography, muscle mass using dual-energy X-ray absorptiometry, and muscle strength using Keiser's chest and leg press. Insulin sensitivity was measured using the insulin tolerance test, and aerobic capacity was expressed as oxygen uptake at the anaerobic threshold (AT-VO₂) before and after the 12-week exercise program.

Results

The age of participants was 56.4 ± 7.1 years, duration of diabetes was 5.9 ± 5.5 years, and BMI was 27.4 ± 2.5 kg/m², without significant differences between two groups. During intervention, a greater increase in muscle mass and greater decreases in both total fat mass and abdominal fat were observed in RG compared to those of CG (P = 0.015, P = 0.011, P = 0.010, respectively). Increase in 1RM of upper and lower extremities was observed in the RG (P = 0.004, P = 0.040, respectively), without changes in AT-VO₂ and insulin resistance in either group.

Conclusion

In conclusion, the low intensity resistance training was effective in increasing muscle mass and strength and reducing total fat mass without change of insulin sensitivity in type 2 diabetic patients.

Citations

Citations to this article as recorded by

Optimal strategies for exercise intervention in older people diabetic patients: The impacts of intensity, form, and frequency on glycemic control
Xueru Yan, Yujuan Lu, Haoda Zhang, Chen Zhu, Lan Tian, Jishuai Chen, Enpeng He, Yingying Li
Archives of Gerontology and Geriatrics.2025; 128: 105621. CrossRef
The Impact of Resistance Exercise Training on Glycemic Control Among Adults with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Yuwen Wan, Zhanguo Su
Biological Research For Nursing.2024; 26(4): 597. CrossRef
Effect of a home‐based physical activity program on metabolic syndrome in Ghanaian adults with type 2 diabetes: Protocol for a feasibility randomized controlled trial
Mohammed Amin, Debra Kerr, Yacoba Atiase, Misbah Muhammad Samir, Andrea Driscoll
Nursing Open.2024;[Epub] CrossRef
The Effects of Exercise Interventions on Ectopic and Subcutaneous Fat in Patients with Type 2 Diabetes Mellitus: A Systematic Review, Meta-Analysis, and Meta-Regression
Fatemeh Kazeminasab, Ali Bahrami Kerchi, Nasim Behzadnejad, Saba Belyani, Sara K. Rosenkranz, Reza Bagheri, Fred Dutheil
Journal of Clinical Medicine.2024; 13(17): 5005. CrossRef
Effects of resistance training on cardiovascular risk factors in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials
Yan Sun, Mingwei Sun, Xia Zeng, Liojuan Xiang Je, Zhannguo Su Guo
Acta Diabetologica.2024;[Epub] CrossRef
Current trends in the development of soy-based foods containing probiotics and paving the path for soy-synbiotics
Minnu Sasi, Sandeep Kumar, Muzaffar Hasan, Arpitha S. R., Enriqueta Garcia-Gutierrez, Sweta Kumari, Om Prakash, Lata Nain, Archana Sachdev, Anil Dahuja
Critical Reviews in Food Science and Nutrition.2023; 63(29): 9995. CrossRef
Communication Strategies and Resources for Health and Fitness Professionals to Minimize Diabetes-Related Social Stigma
Lindsay J. Della, Annika Reitenga, Kristi M. King
ACSM'S Health & Fitness Journal.2023; 27(2): 54. CrossRef
IMPACTS OF MUSCLE TRAINING LOADS ON COLLEGE STUDENTS' PHYSICAL FITNESS
Wang Lu, Zheng Hua, Wang Tailin, Wei Xuanxi
Revista Brasileira de Medicina do Esporte.2023;[Epub] CrossRef
Effect of resistance training on HbA1c in adults with type 2 diabetes mellitus and the moderating effect of changes in muscular strength: a systematic review and meta-analysis
Anna K Jansson, Li X Chan, David R Lubans, Mitch J Duncan, Ronald C Plotnikoff
BMJ Open Diabetes Research & Care.2022; 10(2): e002595. CrossRef
Role of genetic factors (biology of telomeres) in cardiac rehabilitation
D. M. Aronov, O. M. Drapkina, M. G. Bubnova
Cardiovascular Therapy and Prevention.2022; 21(6): 3272. CrossRef
Effects of 12-Week Progressive Sandbag Exercise Training on Glycemic Control and Muscle Strength in Patients with Type 2 Diabetes Mellitus Combined with Possible Sarcopenia
Yu-Hsuan Chien, Chia-Jen Tsai, Dean-Chuan Wang, Pin-Hung Chuang, Hwai-Ting Lin
International Journal of Environmental Research and Public Health.2022; 19(22): 15009. CrossRef
Effects of Online Live Pilates Training during the COVID-19 Pandemic on Body Composition, Cardiovascular Function, and Physical Fitness in Sedentary Middle-aged Obese Women
Jung-Heon Choi, Ko-Eun Choi, Man-Gyoon Lee
Korean Journal of Sport Science.2022; 33(4): 521. CrossRef
Muscular Strength, Functional Fitness, Body Composition, and Quality of Life after 12 Weeks of Detraining in Older Females
Matúš Krčmár, Nora Halmová, Jaroslav Krajčovič, Bohumila Krčmárová
Physical & Occupational Therapy In Geriatrics.2021; 39(2): 129. CrossRef
Comparison between different types of exercise training in patients with type 2 diabetes mellitus: A systematic review and network metanalysis of randomized controlled trials
Edoardo Mannucci, Allegra Bonifazi, Matteo Monami
Nutrition, Metabolism and Cardiovascular Diseases.2021; 31(7): 1985. CrossRef
DETERMINING NEW ANTHROPOMETRIC MARKERS FOR SCREENING TYPE 2 DM IN A CARIBBEAN REGION.
Amruta Rajput, Upendra K Gupta, Guri Tzivion, Ravindrasingh Rajput
INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH.2021; : 58. CrossRef
Effect of elastic band resistance training with green coffee extract supplementation on adiposity indices and TyG-related Indicators in Obese Women
Zahra Rashidi, Rezvan Beigi, Majid Mardaniyan Ghahfarrokhi, Mohammad Faramarzi, Ebrahim Banitalebi, Tina Jafari, Conrad P. Earnest, Julien S. Baker
Obesity Medicine.2021; 24: 100351. CrossRef
Effect of resistance training with and without caloric restriction on visceral fat: A systemic review and meta‐analysis
Mousa Khalafi, Abbas Malandish, Sara K. Rosenkranz, Ali A. Ravasi
Obesity Reviews.2021;[Epub] CrossRef
The Effect of Elastic Resistance Band Training on Postural Control and Body Composition in Sedentary Women
Yağmur KOCAOĞLU, Nurtekin ERKMEN
Spor Bilimleri Araştırmaları Dergisi.2021; 6(1): 233. CrossRef
Strength Training and Insulin Resistance: The Mediating Role of Body Composition
McKayla J. Niemann, Larry A. Tucker, Bruce W. Bailey, Lance E. Davidson
Journal of Diabetes Research.2020; 2020: 1. CrossRef
Beyond general resistance training. Hypertrophy versus muscular endurance training as therapeutic interventions in adults with type 2 diabetes mellitus: A systematic review and meta‐analysis
Pedro Acosta‐Manzano, María Rodriguez‐Ayllon, Francisco M. Acosta, David Niederseer, Josef Niebauer
Obesity Reviews.2020;[Epub] CrossRef
Resistance Exercise Intensity is Correlated with Attenuation of HbA1c and Insulin in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis
Yubo Liu, Weibing Ye, Qian Chen, Yong Zhang, Chia-Hua Kuo, Mallikarjuna Korivi
International Journal of Environmental Research and Public Health.2019; 16(1): 140. CrossRef
Effectiveness of Exercise Intervention in Reducing Body Weight and Glycosylated Hemoglobin Levels in Patients with Type 2 Diabetes Mellitus in Korea: A Systematic Review and Meta-Analysis
Ji-Eun Jang, Yongin Cho, Byung Wan Lee, Ein-Soon Shin, Sun Hee Lee
Diabetes & Metabolism Journal.2019; 43(3): 302. CrossRef
Effects of a moderate-to-high intensity resistance circuit training on fat mass, functional capacity, muscular strength, and quality of life in elderly: A randomized controlled trial
Pablo Jorge Marcos-Pardo, Francisco Javier Orquin-Castrillón, Gemma María Gea-García, Ruperto Menayo-Antúnez, Noelia González-Gálvez, Rodrigo Gomes de Souza Vale, Alejandro Martínez-Rodríguez
Scientific Reports.2019;[Epub] CrossRef
Effects of Resistance Exercise on Glycated Hemoglobin and Functional Performance in Older Patients with Comorbid Diabetes Mellitus and Knee Osteoarthritis: A Randomized Trial
Shu-Mei Chen, Feng-Chih Shen, Jung-Fu Chen, Wen-Dien Chang, Nai-Jen Chang
International Journal of Environmental Research and Public Health.2019; 17(1): 224. CrossRef
Effects of low‐intensity resistance training on muscular function and glycemic control in older adults with type 2 diabetes
Eri Takenami, ShinMin Iwamoto, Noriko Shiraishi, Akiko Kato, Yuichi Watanabe, Yoshifumi Yamada, Satoru Yamada, Naokata Ishii
Journal of Diabetes Investigation.2019; 10(2): 331. CrossRef
Effect of 12-Month Resistance Training on Changes in Abdominal Adipose Tissue and Metabolic Variables in Patients with Prediabetes: A Randomized Controlled Trial
Juan Yan, Xia Dai, Jitao Feng, Xiaodan Yuan, Jianing Li, Lihong Yang, Panpan Zuo, Zhaohui Fang, Chao Liu, Cunyi Hsue, Junya Zhu, Joshua D. Miller, Qingqing Lou
Journal of Diabetes Research.2019; 2019: 1. CrossRef
Positive Effects of a Short-Term Intense Elastic Resistance Training Program on Body Composition and Physical Functioning in Overweight Older Women
Nicole B. Fritz, Álvaro Juesas, Pedro Gargallo, Joaquín Calatayud, Julio Fernández-Garrido, Michael E. Rogers, Juan C. Colado
Biological Research For Nursing.2018; 20(3): 321. CrossRef
Protein timing during the day and its relevance for muscle strength and lean mass
Samuel L. Buckner, Jeremy P. Loenneke, Paul D. Loprinzi
Clinical Physiology and Functional Imaging.2018; 38(2): 332. CrossRef
Exercise training modalities in patients with type 2 diabetes mellitus: a systematic review and network meta-analysis
Bei Pan, Long Ge, Yang-qin Xun, Ya-jing Chen, Cai-yun Gao, Xue Han, Li-qian Zuo, Hou-qian Shan, Ke-hu Yang, Guo-wu Ding, Jin-hui Tian
International Journal of Behavioral Nutrition and Physical Activity.2018;[Epub] CrossRef
Resistance training reduces metabolic syndrome and inflammatory markers in older women: A randomized controlled trial
Crisieli M. Tomeleri, Mariana F. Souza, Roberto C. Burini, Cláudia R. Cavaglieri, Alex S. Ribeiro, Melissa Antunes, João P. Nunes, Danielle Venturini, Décio S. Barbosa, Luís B. Sardinha, Edilson S. Cyrino
Journal of Diabetes.2018; 10(4): 328. CrossRef
Effect of Resistance Training with Blood Flow Restriction on Follistatin to Myostatin Ratio, Body Composition and Anaerobic Power of Trained-Volleyball Players
Reza Bagheri, Amir Rashidlamir, Seyyed Reza Attarzadeh Hosseini
Medical Laboratory Journal.2018; 12(6): 28. CrossRef
Effects of 8-week kettlebell training on body composition, muscle strength, pulmonary function, and chronic low-grade inflammation in elderly women with sarcopenia
Hung-Ting Chen, Huey-June Wu, Yu-Jen Chen, Sung-Yen Ho, Yu-Chun Chung
Experimental Gerontology.2018; 112: 112. CrossRef
F inding the O ptimal volume and intensity of R esistance T raining E xercise for Type 2 Diabetes: The FORTE Study, a Randomized Trial
Pearl Yang, Walter Swardfager, Daniel Fernandes, Sheila Laredo, George Tomlinson, Paul I. Oh, Scott Thomas
Diabetes Research and Clinical Practice.2017; 130: 98. CrossRef
Exercise and ectopic fat in type 2 diabetes: A systematic review and meta-analysis
A. Sabag, K.L. Way, S.E. Keating, R.N. Sultana, H.T. O’Connor, M.K. Baker, V.H. Chuter, J. George, N.A. Johnson
Diabetes & Metabolism.2017; 43(3): 195. CrossRef
Resistance training to improve type 2 diabetes: working toward a prescription for the future
Dominik H. Pesta, Renata L. S. Goncalves, Anila K. Madiraju, Barbara Strasser, Lauren M. Sparks
Nutrition & Metabolism.2017;[Epub] CrossRef
Improvement of obesity-linked skeletal muscle insulin resistance by strength and endurance training
Sergio Di Meo, Susanna Iossa, Paola Venditti
Journal of Endocrinology.2017; 234(3): R159. CrossRef
Leisure time sedentary behavior, physical activity and frequency of protein consumption on lower extremity strength and lean mass
P D Loprinzi, J P Loenneke, D L Hamilton
European Journal of Clinical Nutrition.2017; 71(12): 1399. CrossRef
Strength Training Prevents Hyperinsulinemia, Insulin Resistance, and Inflammation Independent of Weight Loss in Fructose-Fed Animals
José D. Botezelli, Andressa Coope, Ana C. Ghezzi, Lucieli T. Cambri, Leandro P. Moura, Pedro P. M. Scariot, Rodrigo Stellzer Gaspar, Rania A. Mekary, Eduardo Rochete Ropelle, José Rodrigo Pauli
Scientific Reports.2016;[Epub] CrossRef
Effects of Elastic Band Resistance Training on Glucose Control, Body Composition, and Physical Function in Women With Short- vs. Long-Duration Type-2 Diabetes
Bong-Sup Park, Andy V. Khamoui, Lee E. Brown, Do-Youn Kim, Kyung-Ah Han, Kyung-Wan Min, Geun-Hee An
Journal of Strength and Conditioning Research.2016; 30(6): 1688. CrossRef
Neuromuscular dysfunction in type 2 diabetes: underlying mechanisms and effect of resistance training
Giorgio Orlando, Stefano Balducci, Ilenia Bazzucchi, Giuseppe Pugliese, Massimo Sacchetti
Diabetes/Metabolism Research and Reviews.2016; 32(1): 40. CrossRef
Physical exercises with free weights and elastic bands can improve body composition parameters in postmenopausal women
Simoni T. Bittar, Sergio S. Maeda, Marília M.S. Marone, Cláudio Santili
Menopause.2016; 23(4): 383. CrossRef
Effects of exercise training using resistance bands on glycaemic control and strength in type 2 diabetes mellitus: a meta-analysis of randomised controlled trials
Samantha K. McGinley, Marni J. Armstrong, Normand G. Boulé, Ronald J. Sigal
Acta Diabetologica.2015; 52(2): 221. CrossRef
Effect of exercise training on neuromuscular function of elbow flexors and knee extensors of type 2 diabetic patients
I. Bazzucchi, G. De Vito, F. Felici, S. Dewhurst, A. Sgadari, M. Sacchetti
Journal of Electromyography and Kinesiology.2015; 25(5): 815. CrossRef
Effects of short term elastic resistance training on muscle mass and strength in untrained older adults: a randomized clinical trial
Wagner Rodrigues Martins, Marisete Peralta Safons, Martim Bottaro, Juscelino Castro Blasczyk, Leonardo Rios Diniz, Romulo Maia Carlos Fonseca, Ana Clara Bonini-Rocha, Ricardo Jacó de Oliveira
BMC Geriatrics.2015;[Epub] CrossRef
Brain-derived neurotrophic factor correlated with muscle strength in subjects undergoing stationary bicycle exercise training
Sen-Wei Tsai, Yin-Ching Chan, Francois Liang, Chiann-Yi Hsu, I-Te Lee
Journal of Diabetes and its Complications.2015; 29(3): 367. CrossRef
Implementation of Resources to Support Patient Physical Activity through Diabetes Centres in Nova Scotia: The Effectiveness of Enhanced Support for Exercise Participation
Jonathon R. Fowles, Chris Shields, Lisette d’Entremont, Stephanie McQuaid, Brittany Barron, Peggy Dunbar
Canadian Journal of Diabetes.2014; 38(6): 423. CrossRef
Changes in insulin sensitivity in response to different modalities of exercise: a review of the evidence
S. Mann, C. Beedie, S. Balducci, S. Zanuso, J. Allgrove, F. Bertiato, A. Jimenez
Diabetes/Metabolism Research and Reviews.2014; 30(4): 257. CrossRef
The surprising influence of family history to type 2 diabetes on anaerobic performance of young male élite athletes
Antonino Bianco, Francesco Pomara, Antonino Patti, Ewan Thomas, Marco Petrucci, Marianna Bellafiore, Giuseppe Battaglia, Antonio Paoli, Antonio Palma
SpringerPlus.2014;[Epub] CrossRef
Skeletal muscle and organ masses differ in overweight adults with type 2 diabetes
Lance E. Davidson, David E. Kelley, Stanley Heshka, John Thornton, F. Xavier Pi-Sunyer, Lawrence Boxt, Ashok Balasubramanyam, Dympna Gallagher
Journal of Applied Physiology.2014; 117(4): 377. CrossRef
The effects of elastic band resistance training combined with blood flow restriction on strength, total bone‐free lean body mass and muscle thickness in postmenopausal women
Robert S. Thiebaud, Jeremy P. Loenneke, Christopher A. Fahs, Lindy M. Rossow, Daeyeol Kim, Takashi Abe, Mark A. Anderson, Kaelin C. Young, Debra A. Bemben, Michael G. Bemben
Clinical Physiology and Functional Imaging.2013; 33(5): 344. CrossRef
Predicting Aerobic Fitness Improvements after Participation in a Hybrid Supervised and Home-Based Exercise Program in People with Type 2 Diabetes
Pearl Yang, Paul Oh
Canadian Journal of Diabetes.2013; 37(6): 388. CrossRef
Impacto do treinamento resistido na força e hipertrofia muscular em HIV-soropositivos
Ciro José Brito, Edmar Lacerda Mendes, Aparecido Pimentel Ferreira, Sérgio Oliveira De Paula, Otávio de Tolêdo Nóbrega, Cláudio Córdova
Motriz: Revista de Educação Física.2013; 19(2): 313. CrossRef
Resistance Training for Diabetes Prevention and Therapy: Experimental Findings and Molecular Mechanisms
Barbara Strasser, Dominik Pesta
BioMed Research International.2013; 2013: 1. CrossRef
Resistance training, visceral obesity and inflammatory response: a review of the evidence
B. Strasser, M. Arvandi, U. Siebert
Obesity Reviews.2012; 13(7): 578. CrossRef
The effects of resistance training on ApoB/ApoA-I ratio, Lp(a) and inflammatory markers in patients with type 2 diabetes
Nikolaos P. E. Kadoglou, Grigorios Fotiadis, Zoi Athanasiadou, Ioulia Vitta, Stylianos Lampropoulos, Ioannis S. Vrabas
Endocrine.2012; 42(3): 561. CrossRef
A systematic review and meta‐analysis of the effect of aerobic vs. resistance exercise training on visceral fat
I. Ismail, S. E. Keating, M. K. Baker, N. A. Johnson
Obesity Reviews.2012; 13(1): 68. CrossRef
Aging, Resistance Training, and Diabetes Prevention
Kyle D. Flack, Kevin P. Davy, Matthew W. Hulver, Richard A. Winett, Madlyn I. Frisard, Brenda M. Davy
Journal of Aging Research.2011; 2011: 1. CrossRef
The Effects of Aerobic/Resistance Exercise on Body Fat Mass, Muscle Strength and Endothelial Function in Korean Type 2 Diabetes mellitus Patients
Kyung Wan Min
Journal of Korean Diabetes.2011; 12(1): 6. CrossRef
Exercise and Type 2 Diabetes
Sheri R. Colberg, Ronald J. Sigal, Bo Fernhall, Judith G. Regensteiner, Bryan J. Blissmer, Richard R. Rubin, Lisa Chasan-Taber, Ann L. Albright, Barry Braun
Diabetes Care.2010; 33(12): e147. CrossRef

Effects of Aerobic Exercise on Abdominal Fat, Thigh Muscle Mass and Muscle Strength in Type 2 Diabetic Subject: Hwi Ryun Kwon, Kyung Wan Min, Hee Jung Ahn, Hee Geum Seok, Bo Kyung Koo, Ho Chul Kim, Kyung Ah Han; Korean Diabetes J. 2010;34(1):23-31. Published online February 28, 2010; DOI: https://doi.org/10.4093/kdj.2010.34.1.23

4,573 View
49 Download
19 Crossref

Abstract PDF PubReader

Background

Aerobic exercise can effectively reduce visceral fat. However, few studies have examined the effect of daily physical activity on obesity and cardiopulmonary function in the subjects with diabetes. We examined the effect of moderate intensity of walking in obese diabetes patients by monitoring of daily activity and measuring the change in abdominal fat area, muscle are and maximal muscle strength.

Methods

We randomly assigned 27 obese women with type 2 diabetes to an aerobic exercise group (AG, n = 13) and control group (CG, n = 14). The AG performed moderate intensity walking for 60 minutes per exercise, 5 times per week, and for 12 weeks. The activity energy expenditure was monitored by a multi-record accelerometer. The CG maintained routine daily activities. At the time of the initiation of the study and after 12 weeks of exercise, the aerobic exercise capacity was assessed using oxygen consumption rate at anaerobic threshold (VO₂-AT). The abdominal fat area and the quadriceps muscle area were measured by computed tomography, and the maximum muscle strength of the upper and lower limbs was measured by a chest press and a leg press, respectively.

Results

The mean age of the study subjects was 56.6 ± 8.0 years, the mean duration of diabetes was 6.3 ± 6.0 years, and the body weight index (BMI) was 27.3 ± 2.7 kg/m². The BMI of the AG was significantly decreased (P = 0.003). In the AG, the visceral fat area and subcutaneous fat area were also significantly decreased (P = 0.018 and P < 0.001, respectively) but not in CG. VO₂-AT of the AG was significantly improved, while that of the CG did not change (P = 0.009 and P = 0.115, respectively). The quadriceps muscle mass and the maximal muscle strength of the AG did not change, however, the CG showed a significant decrease. Duration of moderate intensity exercise was correlated with the decrease in total abdominal fat area (r = -0.484; P = 0.011) and that of high intensity exercise was correlated with improvement of cardiopulmonary function (r = 0.414; P = 0.032).

Conclusion

Daily moderate intensity aerobic exercise is effective at reducing abdominal fat mass, while high intensity exercise improves cardiopulmonary function.

Citations

Citations to this article as recorded by

Relationship Between Visceral Fat Tissue and Exercise
Ebru Ceviz
Türk Spor Bilimleri Dergisi.2024; 7(1): 10. CrossRef
The Effects of Exercise Interventions on Ectopic and Subcutaneous Fat in Patients with Type 2 Diabetes Mellitus: A Systematic Review, Meta-Analysis, and Meta-Regression
Fatemeh Kazeminasab, Ali Bahrami Kerchi, Nasim Behzadnejad, Saba Belyani, Sara K. Rosenkranz, Reza Bagheri, Fred Dutheil
Journal of Clinical Medicine.2024; 13(17): 5005. CrossRef
Walking for subjects with type 2 diabetes: a systematic review and joint AMD/SID/SISMES evidence-based practical guideline
P. Moghetti, S. Balducci, L. Guidetti, P. Mazzuca, E. Rossi, F. Schena, P. Moghetti, S. Balducci, L. Guidetti, F. Schena, P. Mazzuca, E. Rossi
Sport Sciences for Health.2021; 17(1): 1. CrossRef
Effect of exercise intervention dosage on reducing visceral adipose tissue: a systematic review and network meta-analysis of randomized controlled trials
Yu-Hsuan Chang, Hui-Ying Yang, Shiow-Ching Shun
International Journal of Obesity.2021; 45(5): 982. CrossRef
Comparison between different types of exercise training in patients with type 2 diabetes mellitus: A systematic review and network metanalysis of randomized controlled trials
Edoardo Mannucci, Allegra Bonifazi, Matteo Monami
Nutrition, Metabolism and Cardiovascular Diseases.2021; 31(7): 1985. CrossRef
The Therapeutic Effects of Mild to Moderate Intensity Aerobic Exercise on Glycemic Control in Patients with Type 2 Diabetes Mellitus: A Meta-Analysis of Randomized Trials
Siyao Gao, Jialing Tang, Guozhong Yi, Zhong Li, Zhenyin Chen, Ling Yu, Feng Zheng, Yajing Hu, Zhangui Tang
Diabetes Therapy.2021; 12(10): 2767. CrossRef
Walking for subjects with type 2 diabetes: A systematic review and joint AMD/SID/SISMES evidence-based practical guideline
P. Moghetti, S. Balducci, L. Guidetti, P. Mazzuca, E. Rossi, F. Schena
Nutrition, Metabolism and Cardiovascular Diseases.2020; 30(11): 1882. CrossRef
Effect of Coordinative Locomotor Training Program on Body Fat and Muscle mass of Male University students
Hyung chun Nam, Nam jeong Cho, Jae yong Choi
Archives of Orthopedic and Sports Physical Therapy.2019; 15(2): 109. CrossRef
Exercise training modalities in patients with type 2 diabetes mellitus: a systematic review and network meta-analysis
Bei Pan, Long Ge, Yang-qin Xun, Ya-jing Chen, Cai-yun Gao, Xue Han, Li-qian Zuo, Hou-qian Shan, Ke-hu Yang, Guo-wu Ding, Jin-hui Tian
International Journal of Behavioral Nutrition and Physical Activity.2018;[Epub] CrossRef
Exercise and ectopic fat in type 2 diabetes: A systematic review and meta-analysis
A. Sabag, K.L. Way, S.E. Keating, R.N. Sultana, H.T. O’Connor, M.K. Baker, V.H. Chuter, J. George, N.A. Johnson
Diabetes & Metabolism.2017; 43(3): 195. CrossRef
A systematic review and meta‐analysis on the effects of exercise training versus hypocaloric diet: distinct effects on body weight and visceral adipose tissue
R. J. H. M. Verheggen, M. F. H. Maessen, D. J. Green, A. R. M. M. Hermus, M. T. E. Hopman, D. H. T. Thijssen
Obesity Reviews.2016; 17(8): 664. CrossRef
Effects of Aerobic Exercise Associated with Abdominal Microcurrent: A Preliminary Study
Andreia Noites, Rita Nunes, Ana Isabel Gouveia, Alexandra Mota, Cristina Melo, Ágata Viera, Nuno Adubeiro, José Mesquita Bastos
The Journal of Alternative and Complementary Medicine.2015; 21(4): 229. CrossRef
Brain-derived neurotrophic factor correlated with muscle strength in subjects undergoing stationary bicycle exercise training
Sen-Wei Tsai, Yin-Ching Chan, Francois Liang, Chiann-Yi Hsu, I-Te Lee
Journal of Diabetes and its Complications.2015; 29(3): 367. CrossRef
Impact of Walking on Glycemic Control and Other Cardiovascular Risk Factors in Type 2 Diabetes: A Meta-Analysis
Shanhu Qiu, Xue Cai, Uwe Schumann, Martina Velders, Zilin Sun, Jürgen Michael Steinacker, Lamberto Manzoli
PLoS ONE.2014; 9(10): e109767. CrossRef
A systematic review and meta‐analysis of the effect of aerobic vs. resistance exercise training on visceral fat
I. Ismail, S. E. Keating, M. K. Baker, N. A. Johnson
Obesity Reviews.2012; 13(1): 68. CrossRef
The Effects of Regular Pilates Exercise on Blood pressure and Pulmonary Variables
Gyu-Chang Lee, Dong-Yeop Lee, Jae-Ho Yu
Journal of the Korea Academia-Industrial cooperation Society.2011; 12(7): 3088. CrossRef
The Effects of Aerobic/Resistance Exercise on Body Fat Mass, Muscle Strength and Endothelial Function in Korean Type 2 Diabetes mellitus Patients
Kyung Wan Min
Journal of Korean Diabetes.2011; 12(1): 6. CrossRef
The Evaluation of Workplace Obesity Intervention Program using Six Sigma Methodology
Ji Yeon Kang, Ill Keun Park, Yun Kyun Chang, Sook Hee Sung, Yoo Kyoung Park, Sang Woon Cho, Yun Mi Paek, Tae In Choi
The Korean Journal of Obesity.2011; 20(4): 193. CrossRef
How Can We Measure the Effects of Exercise in Daily Life?
Sang Yong Kim
Korean Diabetes Journal.2010; 34(1): 21. CrossRef

Author index