Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal

Search
OPEN ACCESS

Author index

Page Path
HOME > Browse > Author index
Search
Kun Chen  (Chen K) 1 Article
Epidemiology
Association of Visit-to-Visit Variability of Blood Pressure with Cardiovascular Disease among Type 2 Diabetes Mellitus Patients: A Cohort Study
Zhe-Bin Yu, Die Li, Xue-Yu Chen, Pei-Wen Zheng, Hong-Bo Lin, Meng-Ling Tang, Ming-Juan Jin, Jian-Bing Wang, Kun Chen
Diabetes Metab J. 2019;43(3):350-367.   Published online March 6, 2019
DOI: https://doi.org/10.4093/dmj.2018.0108
  • 5,186 View
  • 79 Download
  • 10 Web of Science
  • 11 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   
Background

Increasing evidence has shown that visit-to-visit variability (VVV) of blood pressure (BP) is associated with an increased risk of cardiovascular disease (CVD). The objective of this study was to evaluate the impact of VVV of systolic blood pressure (SBP) and diastolic blood pressure (DBP) on the risk of CVD among patients with type 2 diabetes mellitus (T2DM) in China.

Methods

We conducted a retrospective cohort study of 10,163 T2DM patients who were not previously diagnosed with CVD from January 2008 to December 2012 in Ningbo, China. The VVV of BP was calculated using five metrics, including standard deviation (SD), coefficient of variation (CV), variation independent of mean, average real variability, and successive variability (SV) of measurements, obtained over a 24-month measurement period. Hazard ratios and 95% confidence intervals (CIs) were estimated by Cox proportional hazards regression models for the associations of variability in BP with risk of CVD.

Results

A total of 894 CVD events were observed during a median follow-up of 49.5 months. The hazard ratio in the highest quintile of SD of SBP was 1.24 (95% CI, 1.01 to 1.52) compared with patients in the lowest quintile. The association between higher VVV of DBP and risk of CVD was not consistent across different metrics and sensitivity analyses.

Conclusion

Higher VVV of SBP was associated with an increased risk of CVD, irrespective of the mean SBP level. Future studies are needed to confirm these findings.

Citations

Citations to this article as recorded by  
  • Association between Variability of Metabolic Risk Factors and Cardiometabolic Outcomes
    Min Jeong Park, Kyung Mook Choi
    Diabetes & Metabolism Journal.2022; 46(1): 49.     CrossRef
  • Joint effect of blood pressure and glycemic variation on the risk of cardiovascular morbidity and mortality in persons with type 2 diabetes
    Cheng-Chieh Lin, Chia-Ing Li, Ya-Ling Juan, Chiu-Shong Liu, Chih-Hsueh Lin, Shing-Yu Yang, Tsai-Chung Li
    Metabolism.2022; 136: 155308.     CrossRef
  • Visit‐to‐visit variability of blood pressure and risk of macrovascular and microvascular complications in patients with type 2 diabetes: A Chinese primary‐care cohort study
    Ying Deng, Yin Liu, Shengchao Zhang, Hanbing Yu, Xiaozhou Zeng, Rongrong An, Zhenyuan Chen, Na Sun, Xiaoxv Yin, Yue Dong
    Journal of Diabetes.2022; 14(11): 767.     CrossRef
  • Visit‑to‑visit blood pressure variability is associated with arterial stiffness in Chinese adults: A prospective analysis
    Yuwen Zhang, Lizhan Bie, Mian Li, Tiange Wang, Min Xu, Jieli Lu, Shuangyuan Wang, Jie Zhang, Yufang Bi, Weiqing Wang, Guang Ning, Yuhong Chen, Yu Xu
    The Journal of Clinical Hypertension.2021; 23(4): 802.     CrossRef
  • Variability of risk factors and diabetes complications
    Antonio Ceriello, Francesco Prattichizzo
    Cardiovascular Diabetology.2021;[Epub]     CrossRef
  • Effectiveness of statin intensive therapy in type 2 diabetes mellitus with high visit-to-visit blood pressure variability
    Shota Ikeda, Keisuke Shinohara, Nobuyuki Enzan, Shouji Matsushima, Takeshi Tohyama, Kouta Funakoshi, Junji Kishimoto, Hiroshi Itoh, Issei Komuro, Hiroyuki Tsutsui
    Journal of Hypertension.2021; 39(7): 1435.     CrossRef
  • Prognostic importance of visit-to-visit blood pressure variability for micro- and macrovascular outcomes in patients with type 2 diabetes: The Rio de Janeiro Type 2 Diabetes Cohort Study
    Claudia R. L. Cardoso, Nathalie C. Leite, Gil F. Salles
    Cardiovascular Diabetology.2020;[Epub]     CrossRef
  • Impact of visit-to-visit variability in blood pressure on coronary plaque as assessed by integrated backscatter intravascular ultrasound
    Yuta Kato, Atsushi Iwata, Makito Futami, Motoki Yamashita, Eiji Shigemoto, Takashi Kuwano, Makoto Sugihara, Shin-Ichiro Miura
    Clinical and Experimental Hypertension.2020; 42(7): 608.     CrossRef
  • VISIT-TO-VISIT BLOOD PRESSURE VARIABILITY IN RURAL MALES WITH ARTERIAL HYPERTENSION: ASSOCIATION WITH NON-VALVULAR ATRIAL FIBRILLATION
    T.I. Nimtsovych, A.M. Kravchenko, O.Yu. Mishcheniuk, К.О. Mikhaliev, T.Ya. Chursina
    Клінічна та профілактична медицина.2020; (2): 90.     CrossRef
  • VISIT-TO-VISIT BLOOD PRESSURE VARIABILITY AND TARGET ORGAN DAMAGE IN RURAL DWELLERS WITH UNCOMPLICATED ARTERIAL HYPERTENSION
    Tetiana I. Nimtsovych, Anatolii M. Kravchenko, Olha Yu. Mishcheniuk, Tamara Ya. Chursina, Кyrylo О. Mikhaliev, Viktor P. Polovyi
    Wiadomości Lekarskie.2020; 73(12): 2591.     CrossRef
  • HDL-Cholesterol, Its Variability, and the Risk of Diabetes: A Nationwide Population-Based Study
    Seung-Hwan Lee, Hun-Sung Kim, Yong-Moon Park, Hyuk-Sang Kwon, Kun-Ho Yoon, Kyungdo Han, Mee Kyoung Kim
    The Journal of Clinical Endocrinology & Metabolism.2019; 104(11): 5633.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal