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Ki-Cheor Bae  (Bae KC) 1 Article
Effect of Green Tea Extract/Poly-γ-Glutamic Acid Complex in Obese Type 2 Diabetic Mice
Ki-Cheor Bae, Jae-Hyung Park, Ann-Yae Na, Sun-Joo Kim, Shinbyoung Ahn, Sang-Pyo Kim, Byung-Chul Oh, Ho-Chan Cho, Yong Woon Kim, Dae-Kyu Song
Diabetes Metab J. 2013;37(3):196-206.   Published online June 14, 2013
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AbstractAbstract PDFPubReader   

The increasing prevalence of type 2 diabetes mellitus (T2DM) is associated with the rapid spread of obesity. Obesity induces insulin resistance, resulting in β-cell dysfunction and thus T2DM. Green tea extract (GTE) has been known to prevent obesity and T2DM, but this effect is still being debated. Our previous results suggested that circulating green tea gallated catechins (GCs) hinders postprandial blood glucose lowering, regardless of reducing glucose and cholesterol absorption when GCs are present in the intestinal lumen. This study aimed to compare the effect of GTE with that of GTE coadministered with poly-γ-glutamic acid (γ-PGA), which is likely to inhibit the intestinal absorption of GCs.


The db/db mice and age-matched nondiabetic mice were provided with normal chow diet containing GTE (1%), γ-PGA (0.1%), or GTE+γ-PGA (1%:0.1%) for 4 weeks.


In nondiabetic mice, none of the drugs showed any effects after 4 weeks. In db/db mice, however, weight gain and body fat gain were significantly reduced in the GTE+γ-PGA group compared to nondrug-treated db/db control mice without the corresponding changes in food intake and appetite. Glucose intolerance was also ameliorated in the GTE+γ-PGA group. Histopathological analyses showed that GTE+γ-PGA-treated db/db mice had a significantly reduced incidence of fatty liver and decreased pancreatic islet size. Neither GTE nor γ-PGA treatment showed any significant results.


These results suggest that GTE+γ-PGA treatment than GTE or γ-PGA alone may be a useful tool for preventing both obesity and obesity-induced T2DM.


Citations to this article as recorded by  
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    Foods.2023; 12(9): 1748.     CrossRef
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  • Anti-inflammatory activities of green tea catechins along the gut–liver axis in nonalcoholic fatty liver disease: lessons learned from preclinical and human studies
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  • Role of PCK1 gene on oil tea-induced glucose homeostasis and type 2 diabetes: an animal experiment and a case-control study
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    Nutrition & Metabolism.2019;[Epub]     CrossRef
  • Oil tea improves glucose and lipid levels and alters gut microbiota in type 2 diabetic mice
    Rui Lin, Xuan He, Huafeng Chen, Qin He, Ziting Yao, Yuanfan Li, Hui Yang, Steve Simpson
    Nutrition Research.2018; 57: 67.     CrossRef
  • Isomalto-oligosaccharides, a prebiotic, functionally augment green tea effects against high fat diet-induced metabolic alterations via preventing gut dysbacteriosis in mice
    Dhirendra Pratap Singh, Jagdeep Singh, Ravneet Kaur Boparai, JianHua Zhu, Shrikant Mantri, Pragyanshu Khare, Romesh Khardori, Kanthi Kiran Kondepudi, Kanwaljit Chopra, Mahendra Bishnoi
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  • Hypoglycemic, Hypolipidemic and Antioxidant Effects of Peptides from Red Deer Antlers in Streptozotocin-Induced Diabetic Mice
    Ning Jiang, Shuangjian Zhang, Jing Zhu, Jing Shang, Xiangdong Gao
    The Tohoku Journal of Experimental Medicine.2015; 236(1): 71.     CrossRef
  • Coffee but not green tea consumption is associated with prevalence and severity of hepatic steatosis: the impact on leptin level
    T Imatoh, S Kamimura, M Miyazaki
    European Journal of Clinical Nutrition.2015; 69(9): 1023.     CrossRef
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    Jae-Hyung Park, Jae-Hoon Bae, Sung-Soon Im, Dae-Kyu Song
    Integrative Medicine Research.2014; 3(1): 4.     CrossRef
  • The Effects of Green Tea on Obesity and Type 2 Diabetes
    Hyun Min Kim, Jaetaek Kim
    Diabetes & Metabolism Journal.2013; 37(3): 173.     CrossRef

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