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Kanako Iwasaki 1 Article
Basic Research
Regulation of Cellular Senescence in Type 2 Diabetes Mellitus: From Mechanisms to Clinical Applications
Kanako Iwasaki, Cristian Abarca, Cristina Aguayo-Mazzucato
Diabetes Metab J. 2023;47(4):441-453.   Published online March 6, 2023
DOI: https://doi.org/10.4093/dmj.2022.0416
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  • 3 Web of Science
  • 5 Crossref
AbstractAbstract PDFPubReader   ePub   
Cellular senescence is accelerated by hyperglycemia through multiple pathways. Therefore, senescence is an important cellular mechanism to consider in the pathophysiology of type 2 diabetes mellitus (T2DM) and an additional therapeutic target. The use of drugs that remove senescent cells has led to improvements in blood glucose levels and diabetic complications in animal studies. Although the removal of senescent cells is a promising approach for the treatment of T2DM, two main challenges limit its clinical application: the molecular basis of cellular senescence in each organ is yet to be understood, and the specific effect of removing senescent cells in each organ has to be determined. This review aims to discuss future applications of targeting senescence as a therapeutic option in T2DM and elucidate the characteristics of cellular senescence and senescence-associated secretory phenotype in the tissues important for regulating glucose levels: pancreas, liver, adipocytes, and skeletal muscle.

Citations

Citations to this article as recorded by  
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    Journal of Natural Products.2024; 87(3): 617.     CrossRef
  • Study on the Pathogenesis of Cell Senescence in Non-Alcoholic Fatty Liver
    丽媛 黄
    Medical Diagnosis.2024; 14(01): 76.     CrossRef
  • Senescent adipocytes and type 2 diabetes – current knowledge and perspective concepts
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    Biomolecular Concepts.2024;[Epub]     CrossRef
  • The Effect of Long-Term Passage on Porcine SMCs’ Function and the Improvement of TGF-β1 on Porcine SMCs’ Secretory Function in Late Passage
    Yan-Yan Zheng, Ze-Nan Hu, Zheng Liu, Yi-Chen Jiang, Ren-Peng Guo, Shi-Jie Ding, Guang-Hong Zhou
    Foods.2023; 12(14): 2682.     CrossRef
  • Exploring the Relationship between Cellular Senescence Markers and Aging-Related Diseases
    怡 罗
    Advances in Clinical Medicine.2023; 13(08): 12298.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal