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Jung Hwa Jung  (Jung JH) 2 Articles
Current Antiplatelet Treatment Strategy in Patients with Diabetes Mellitus
Jung Hwa Jung, Udaya S. Tantry, Paul A. Gurbel, Young-Hoon Jeong
Diabetes Metab J. 2015;39(2):95-113.   Published online April 20, 2015
DOI: https://doi.org/10.4093/dmj.2015.39.2.95
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  • 88 Download
  • 30 Web of Science
  • 24 Crossref
AbstractAbstract PDFPubReader   

Patients with diabetes mellitus (DM) have accelerated atherosclerosis with an increased risk for atherothrombotic cardiovascular complications. A state of high platelet reactivity and activation, hypercoagulability (prothrombotic state) and a subdued response to standard antiplatelet agents may explain high rate of adverse cardiovascular events in patients with DM. Several antithrombotic treatment strategies have been developed to control the prothrombotic state in patients with DM: dose modification of commonly used agents; use of potent agents; and addition of a third antithrombotic drug (triple therapy) to commonly prescribed dual antiplatelet therapy of aspirin and a P2Y12 inhibitor. The present review aims to provide an overview of the current knowledge on platelet abnormalities in patients with DM, focusing on the challenges and perspectives of antiplatelet treatment strategies in this population.

Citations

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  • Platelet Glycoprotein-Ib (GPIb) May Serve as a Bridge between Type 2 Diabetes Mellitus (T2DM) and Atherosclerosis, Making It a Potential Target for Antiplatelet Agents in T2DM Patients
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    Life.2023; 13(7): 1473.     CrossRef
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    Pharmacogenomics.2022; 23(1): 61.     CrossRef
  • Prolonged dual antiplatelet therapy after drug-eluting stent implantation in patients with diabetes mellitus: A nationwide retrospective cohort study
    Seung-Jun Lee, Dong-Woo Choi, Choongki Kim, Yongsung Suh, Sung-Jin Hong, Chul-Min Ahn, Jung-Sun Kim, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Eun-Cheol Park, Yangsoo Jang, Chung-Mo Nam, Myeong-Ki Hong
    Frontiers in Cardiovascular Medicine.2022;[Epub]     CrossRef
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    Terapevticheskii arkhiv.2022; 94(10): 1204.     CrossRef
  • Ischemic and Bleeding Events of Ticagrelor Monotherapy in Korean Patients With and Without Diabetes Mellitus: Insights From the TICO Trial
    Kyeong Ho Yun, Jae Young Cho, Seung Yul Lee, Sang Jae Rhee, Byeong Keuk Kim, Myeong Ki Hong, Yangsoo Jang, Seok Kyu Oh
    Frontiers in Pharmacology.2021;[Epub]     CrossRef
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  • Protective Role of Platelets in Myocardial Infarction and Ischemia/Reperfusion Injury
    Kornela Hałucha, Alina Rak-Pasikowska, Iwona Bil-Lula, David J. Chambers
    Cardiology Research and Practice.2021; 2021: 1.     CrossRef
  • Pre- and Post-Conditioning of the Heart: An Overview of Cardioprotective Signaling Pathways
    Denise Coutinho de Miranda, Gabriela de Oliveira Faria, Milla Marques Hermidorff, Fernanda Cacilda dos Santos Silva, Leonardo Vinícius Monteiro de Assis, Mauro César Isoldi
    Current Vascular Pharmacology.2021; 19(5): 499.     CrossRef
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    Hongyu Zhang, Junsong Ke, Jun Huang, Kai Xu, Yun Chen, Timir Paul
    PLOS ONE.2020; 15(12): e0242845.     CrossRef
  • Long non-coding RNA metallothionein 1 pseudogene 3 promotes p2y12 expression by sponging miR-126 to activate platelet in diabetic animal model
    Ming Zhou, Meng Gao, Yanwei Luo, Rong Gui, Hongwen Ji
    Platelets.2019; 30(4): 452.     CrossRef
  • Circulating blood cells and extracellular vesicles in acute cardioprotection
    Sean M Davidson, Ioanna Andreadou, Lucio Barile, Yochai Birnbaum, Hector A Cabrera-Fuentes, Michael V Cohen, James M Downey, Henrique Girao, Pasquale Pagliaro, Claudia Penna, John Pernow, Klaus T Preissner, Péter Ferdinandy
    Cardiovascular Research.2019; 115(7): 1156.     CrossRef
  • Comparison of 1-year clinical outcomes between prasugrel and ticagrelor versus clopidogrel in type 2 diabetes patients with acute myocardial infarction underwent successful percutaneous coronary intervention
    Kye Taek Ahn, Seok-Woo Seong, Ung Lim Choi, Seon-Ah Jin, Jun Hyung Kim, Jae-Hwan Lee, Si Wan Choi, Myung Ho Jeong, Shung Chull Chae, Young Jo Kim, Chong Jin Kim, Hyo-Soo Kim, Myeong-Chan Cho, Hyeon-Cheol Gwon, Jin-Ok Jeong, In-Whan Seong
    Medicine.2019; 98(11): e14833.     CrossRef
  • Fibrin Clot Strength in Patients with Diabetes Mellitus Measured by Thrombelastography
    Benjamin T. Maatman, Glen Schmeisser, Rolf P. Kreutz
    Journal of Diabetes Research.2018; 2018: 1.     CrossRef
  • Role of proprotein convertase subtilisin/kexin type 9 inhibitors in patients with coronary artery disease undergoing percutaneous coronary intervention
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    Expert Review of Cardiovascular Therapy.2018; 16(6): 419.     CrossRef
  • Cardioprotective Properties of Human Platelets Are Lost in Uncontrolled Diabetes Mellitus: A Study in Isolated Rat Hearts
    Isabella Russo, Saveria Femminò, Cristina Barale, Francesca Tullio, Stefano Geuna, Franco Cavalot, Pasquale Pagliaro, Claudia Penna
    Frontiers in Physiology.2018;[Epub]     CrossRef
  • Aortic thrombosis in dogs
    Trevor P.E. Williams, Scott Shaw, Adam Porter, Larry Berkwitt
    Journal of Veterinary Emergency and Critical Care.2017; 27(1): 9.     CrossRef
  • Challenges in Patients with Diabetes: Improving Clinical Outcomes After Percutaneous Coronary Intervention Through EVOlving Stent Technology
    Robert A Byrne, Shmuel Banai, Roisin Colleran, Antonio Colombo
    Interventional Cardiology Review.2017; 13(01): 40.     CrossRef
  • Adding CABG to the Dual Antiplatelet Salad
    Glenn N. Levine, Faisal G. Bakaeen
    Journal of the American College of Cardiology.2017; 69(2): 128.     CrossRef
  • The association between arterial stiffness and tongue manifestations of blood stasis in patients with type 2 diabetes
    Po-Chi Hsu, Yu-Chuen Huang, John Y. Chiang, Hen-Hong Chang, Pei-Yung Liao, Lun-Chien Lo
    BMC Complementary and Alternative Medicine.2016;[Epub]     CrossRef
  • Platelet phenotype changes associated with breast cancer and its treatment
    Chris E. Holmes, Jamie E. Levis, David J. Schneider, Nadia M. Bambace, Deva Sharma, Inder Lal, Marie E. Wood, Hyman B. Muss
    Platelets.2016; 27(7): 703.     CrossRef
Clinical Significance of the Presence of Autonomic and Vestibular Dysfunction in Diabetic Patients with Peripheral Neuropathy
Soo Kyoung Kim, Kyeong Ju Lee, Jong Ryeal Hahm, Sang Min Lee, Tae Sik Jung, Jung Hwa Jung, Sungsu Kim, Deok Ryong Kim, Seong-Ki Ahn, Won-Hee Choi, Soon Il Chung
Diabetes Metab J. 2012;36(1):64-69.   Published online February 17, 2012
DOI: https://doi.org/10.4093/dmj.2012.36.1.64
  • 3,821 View
  • 46 Download
  • 18 Crossref
AbstractAbstract PDFPubReader   
Background

We investigated the prevalence of diabetic autonomic neuropathy (DAN) and vestibular dysfunction (VD) in diabetic patients with peripheral neuropathy.

Methods

Thirty-five diabetic patients with peripheral neuropathy were enrolled from August 2008 to July 2009. All subjects underwent autonomic function tests. Nineteen of the patients (54.3%) underwent videonystagmography.

Results

Diabetic autonomic neuropathy was observed in 28 patients (80%). A mild degree of autonomic failure was observed in 18 patients (64.3%), and a moderate degree of autonomic failure was observed in ten patients (35.7%). Factors related to DAN included diabetic nephropathy (P=0.032), degree of chronic kidney disease (P=0.003), and duration of diabetes (P=0.044). Vestibular dysfunction was observed in 11 of 19 patients (57.9%). There was no significant association between DAN and VD.

Conclusion

Diabetic autonomic neuropathy was observed in 28 diabetic patients (80%) with peripheral neuropathy. Vestibular dysfunction was observed in nearly 60% of diabetic patients with peripheral neuropathy who complained of dizziness but showed no significant association with DAN. Diabetic patients who complained of dizziness need to examine both autonomic function and vestibular function.

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Diabetes Metab J : Diabetes & Metabolism Journal