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Jung Hwa Jung  (Jung JH) 2 Articles
Current Antiplatelet Treatment Strategy in Patients with Diabetes Mellitus
Jung Hwa Jung, Udaya S. Tantry, Paul A. Gurbel, Young-Hoon Jeong
Diabetes Metab J. 2015;39(2):95-113.   Published online April 20, 2015
  • 6,519 View
  • 92 Download
  • 31 Web of Science
  • 25 Crossref
AbstractAbstract PDFPubReader   

Patients with diabetes mellitus (DM) have accelerated atherosclerosis with an increased risk for atherothrombotic cardiovascular complications. A state of high platelet reactivity and activation, hypercoagulability (prothrombotic state) and a subdued response to standard antiplatelet agents may explain high rate of adverse cardiovascular events in patients with DM. Several antithrombotic treatment strategies have been developed to control the prothrombotic state in patients with DM: dose modification of commonly used agents; use of potent agents; and addition of a third antithrombotic drug (triple therapy) to commonly prescribed dual antiplatelet therapy of aspirin and a P2Y12 inhibitor. The present review aims to provide an overview of the current knowledge on platelet abnormalities in patients with DM, focusing on the challenges and perspectives of antiplatelet treatment strategies in this population.


Citations to this article as recorded by  
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    Blood.2024; 143(2): 105.     CrossRef
  • New Score Models for Predicting Bleeding and Ischemic of Ticagrelor Therapy in Patients with Diabetes Mellitus
    Xiaotong Xia, Shu Chen, Chang Cao, YanRong Ye, Yun Shen
    Clinical and Applied Thrombosis/Hemostasis.2024;[Epub]     CrossRef
  • On‐Treatment Platelet Reactivity and Ischemic Outcomes in Patients With Diabetes Mellitus: Two‐Year Results From ADAPT‐DES
    Bahira Shahim, Björn Redfors, Thomas D. Stuckey, Mengdan Liu, Zhipeng Zhou, Bernhard Witzenbichler, Giora Weisz, Michael J. Rinaldi, Franz‐Josef Neumann, D. Christopher Metzger, Timothy D. Henry, David A. Cox, Peter L. Duffy, Bruce R. Brodie, Iva Srdanovi
    Journal of the American Heart Association.2023;[Epub]     CrossRef
  • Platelet Glycoprotein-Ib (GPIb) May Serve as a Bridge between Type 2 Diabetes Mellitus (T2DM) and Atherosclerosis, Making It a Potential Target for Antiplatelet Agents in T2DM Patients
    Muttia Amalia, Meidi Utami Puteri, Fadlina Chany Saputri, Rani Sauriasari, Bambang Widyantoro
    Life.2023; 13(7): 1473.     CrossRef
  • Polymorphisms of Genes Related to Phase II Metabolism and Resistance to Clopidogrel
    Abdullah Alkattan, Ahmed Alkhalifah, Eman Alsalameen, Fatimah Alghanim, Nashwa Radwan
    Pharmacogenomics.2022; 23(1): 61.     CrossRef
  • Prolonged dual antiplatelet therapy after drug-eluting stent implantation in patients with diabetes mellitus: A nationwide retrospective cohort study
    Seung-Jun Lee, Dong-Woo Choi, Choongki Kim, Yongsung Suh, Sung-Jin Hong, Chul-Min Ahn, Jung-Sun Kim, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Eun-Cheol Park, Yangsoo Jang, Chung-Mo Nam, Myeong-Ki Hong
    Frontiers in Cardiovascular Medicine.2022;[Epub]     CrossRef
  • New opportunities of antithrombotic therapy in patients with type 2 diabetes mellitus and stable coronary heart disease for reducing the cardiovascular risk and cardiovascular complications: THEMIS, THEMIS-PCI trials
    Victor I. Kalashnikov, Marina S. Michurova
    Terapevticheskii arkhiv.2022; 94(10): 1204.     CrossRef
  • Ischemic and Bleeding Events of Ticagrelor Monotherapy in Korean Patients With and Without Diabetes Mellitus: Insights From the TICO Trial
    Kyeong Ho Yun, Jae Young Cho, Seung Yul Lee, Sang Jae Rhee, Byeong Keuk Kim, Myeong Ki Hong, Yangsoo Jang, Seok Kyu Oh
    Frontiers in Pharmacology.2021;[Epub]     CrossRef
  • Long-term outcomes of ischaemic stroke patients with diabetes in a multi-ethnic cohort in Singapore
    Ei Zune The, Mei Yen Ng, Geelyn JL Ng, Bernadette GC Er, Amy ML Quek, Prakash Paliwal, Leonard L Yeo, Bernard PL Chan, Vijay K Sharma, Hock Luen Teoh, Eric YH Khoo, Raymond CS Seet
    Annals of the Academy of Medicine, Singapore.2021; 50(1): 16.     CrossRef
  • Protective Role of Platelets in Myocardial Infarction and Ischemia/Reperfusion Injury
    Kornela Hałucha, Alina Rak-Pasikowska, Iwona Bil-Lula, David J. Chambers
    Cardiology Research and Practice.2021; 2021: 1.     CrossRef
  • Pre- and Post-Conditioning of the Heart: An Overview of Cardioprotective Signaling Pathways
    Denise Coutinho de Miranda, Gabriela de Oliveira Faria, Milla Marques Hermidorff, Fernanda Cacilda dos Santos Silva, Leonardo Vinícius Monteiro de Assis, Mauro César Isoldi
    Current Vascular Pharmacology.2021; 19(5): 499.     CrossRef
  • Post-Transcriptional Expression Control in Platelet Biogenesis and Function
    Carolin T. Neu, Tony Gutschner, Monika Haemmerle
    International Journal of Molecular Sciences.2020; 21(20): 7614.     CrossRef
  • The impact of metformin and aspirin on T-cell mediated inflammation: A systematic review of in vitro and in vivo findings
    Tawanda Maurice Nyambuya, Phiwayinkosi Vusi Dludla, Vuyolwethu Mxinwa, Kabelo Mokgalaboni, Siphamandla Raphael Ngcobo, Luca Tiano, Bongani Brian Nkambule
    Life Sciences.2020; 255: 117854.     CrossRef
  • Short- versus long-term dual antiplatelet therapy after second-generation drug-eluting stent implantation in patients with diabetes mellitus: A meta-analysis of randomized controlled trials
    Hongyu Zhang, Junsong Ke, Jun Huang, Kai Xu, Yun Chen, Timir Paul
    PLOS ONE.2020; 15(12): e0242845.     CrossRef
  • Long non-coding RNA metallothionein 1 pseudogene 3 promotes p2y12 expression by sponging miR-126 to activate platelet in diabetic animal model
    Ming Zhou, Meng Gao, Yanwei Luo, Rong Gui, Hongwen Ji
    Platelets.2019; 30(4): 452.     CrossRef
  • Circulating blood cells and extracellular vesicles in acute cardioprotection
    Sean M Davidson, Ioanna Andreadou, Lucio Barile, Yochai Birnbaum, Hector A Cabrera-Fuentes, Michael V Cohen, James M Downey, Henrique Girao, Pasquale Pagliaro, Claudia Penna, John Pernow, Klaus T Preissner, Péter Ferdinandy
    Cardiovascular Research.2019; 115(7): 1156.     CrossRef
  • Comparison of 1-year clinical outcomes between prasugrel and ticagrelor versus clopidogrel in type 2 diabetes patients with acute myocardial infarction underwent successful percutaneous coronary intervention
    Kye Taek Ahn, Seok-Woo Seong, Ung Lim Choi, Seon-Ah Jin, Jun Hyung Kim, Jae-Hwan Lee, Si Wan Choi, Myung Ho Jeong, Shung Chull Chae, Young Jo Kim, Chong Jin Kim, Hyo-Soo Kim, Myeong-Chan Cho, Hyeon-Cheol Gwon, Jin-Ok Jeong, In-Whan Seong
    Medicine.2019; 98(11): e14833.     CrossRef
  • Fibrin Clot Strength in Patients with Diabetes Mellitus Measured by Thrombelastography
    Benjamin T. Maatman, Glen Schmeisser, Rolf P. Kreutz
    Journal of Diabetes Research.2018; 2018: 1.     CrossRef
  • Role of proprotein convertase subtilisin/kexin type 9 inhibitors in patients with coronary artery disease undergoing percutaneous coronary intervention
    Eliano P. Navarese, Michalina Kołodziejczak, Aniela Petrescu, Bernhard Wernly, Michael Lichtenauer, Alexander Lauten, Antonino Buffon, Wojciech Wanha, Vincenzo Pestrichella, Gennaro Sardella, Gaetano Contegiacomo, Udaya Tantry, Kevin Bliden, Jacek Kubica,
    Expert Review of Cardiovascular Therapy.2018; 16(6): 419.     CrossRef
  • Cardioprotective Properties of Human Platelets Are Lost in Uncontrolled Diabetes Mellitus: A Study in Isolated Rat Hearts
    Isabella Russo, Saveria Femminò, Cristina Barale, Francesca Tullio, Stefano Geuna, Franco Cavalot, Pasquale Pagliaro, Claudia Penna
    Frontiers in Physiology.2018;[Epub]     CrossRef
  • Aortic thrombosis in dogs
    Trevor P.E. Williams, Scott Shaw, Adam Porter, Larry Berkwitt
    Journal of Veterinary Emergency and Critical Care.2017; 27(1): 9.     CrossRef
  • Challenges in Patients with Diabetes: Improving Clinical Outcomes After Percutaneous Coronary Intervention Through EVOlving Stent Technology
    Robert A Byrne, Shmuel Banai, Roisin Colleran, Antonio Colombo
    Interventional Cardiology Review.2017; 13(01): 40.     CrossRef
  • Adding CABG to the Dual Antiplatelet Salad
    Glenn N. Levine, Faisal G. Bakaeen
    Journal of the American College of Cardiology.2017; 69(2): 128.     CrossRef
  • The association between arterial stiffness and tongue manifestations of blood stasis in patients with type 2 diabetes
    Po-Chi Hsu, Yu-Chuen Huang, John Y. Chiang, Hen-Hong Chang, Pei-Yung Liao, Lun-Chien Lo
    BMC Complementary and Alternative Medicine.2016;[Epub]     CrossRef
  • Platelet phenotype changes associated with breast cancer and its treatment
    Chris E. Holmes, Jamie E. Levis, David J. Schneider, Nadia M. Bambace, Deva Sharma, Inder Lal, Marie E. Wood, Hyman B. Muss
    Platelets.2016; 27(7): 703.     CrossRef
Clinical Significance of the Presence of Autonomic and Vestibular Dysfunction in Diabetic Patients with Peripheral Neuropathy
Soo Kyoung Kim, Kyeong Ju Lee, Jong Ryeal Hahm, Sang Min Lee, Tae Sik Jung, Jung Hwa Jung, Sungsu Kim, Deok Ryong Kim, Seong-Ki Ahn, Won-Hee Choi, Soon Il Chung
Diabetes Metab J. 2012;36(1):64-69.   Published online February 17, 2012
  • 4,076 View
  • 47 Download
  • 18 Crossref
AbstractAbstract PDFPubReader   

We investigated the prevalence of diabetic autonomic neuropathy (DAN) and vestibular dysfunction (VD) in diabetic patients with peripheral neuropathy.


Thirty-five diabetic patients with peripheral neuropathy were enrolled from August 2008 to July 2009. All subjects underwent autonomic function tests. Nineteen of the patients (54.3%) underwent videonystagmography.


Diabetic autonomic neuropathy was observed in 28 patients (80%). A mild degree of autonomic failure was observed in 18 patients (64.3%), and a moderate degree of autonomic failure was observed in ten patients (35.7%). Factors related to DAN included diabetic nephropathy (P=0.032), degree of chronic kidney disease (P=0.003), and duration of diabetes (P=0.044). Vestibular dysfunction was observed in 11 of 19 patients (57.9%). There was no significant association between DAN and VD.


Diabetic autonomic neuropathy was observed in 28 diabetic patients (80%) with peripheral neuropathy. Vestibular dysfunction was observed in nearly 60% of diabetic patients with peripheral neuropathy who complained of dizziness but showed no significant association with DAN. Diabetic patients who complained of dizziness need to examine both autonomic function and vestibular function.


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  • Subclinical vestibular dysfunction in type 1 diabetes mellitus
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  • Potential Applications of Nanomaterials and Technology for Diabetic Wound Healing

    Que Bai, Kai Han, Kai Dong, Caiyun Zheng, Yanni Zhang, Qianfa Long, Tingli Lu
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  • Recent advancements in biopolymer and metal nanoparticle-based materials in diabetic wound healing management
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    International Journal of Biological Macromolecules.2019; 122: 137.     CrossRef
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  • Impact of Diabetic Complications on Balance and Falls: Contribution of the Vestibular System
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    Journal of Molecular and Cellular Cardiology.2016; 92: 203.     CrossRef
  • Augmented asymmetrical visual field dependence in asymptomatic diabetics: Evidence of subclinical asymmetrical bilateral vestibular dysfunction
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