Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal

Search
OPEN ACCESS

Author index

Page Path
HOME > Browse > Author index
Search
Jung Eun Jang  (Jang JE) 7 Articles
Drug/Regimen
Article image
Efficacy and Safety of Treatment with Quadruple Oral Hypoglycemic Agents in Uncontrolled Type 2 Diabetes Mellitus: A Multi-Center, Retrospective, Observational Study
Jun Sung Moon, Sunghwan Suh, Sang Soo Kim, Heung Yong Jin, Jeong Mi Kim, Min Hee Jang, Kyung Ae Lee, Ju Hyung Lee, Seung Min Chung, Young Sang Lyu, Jin Hwa Kim, Sang Yong Kim, Jung Eun Jang, Tae Nyun Kim, Sung Woo Kim, Eonju Jeon, Nan Hee Cho, Mi-Kyung Kim, Hye Soon Kim, Il Seong Nam-Goong, Eun Sook Kim, Jin Ook Chung, Dong-Hyeok Cho, Chang Won Lee, Young Il Kim, Dong Jin Chung, Kyu Chang Won, In Joo Kim, Tae Sun Park, Duk Kyu Kim, Hosang Shon
Diabetes Metab J. 2021;45(5):675-683.   Published online August 12, 2020
DOI: https://doi.org/10.4093/dmj.2020.0107
  • 36,728 View
  • 388 Download
  • 10 Web of Science
  • 6 Crossref
Graphical AbstractGraphical Abstract AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background

Only few studies have shown the efficacy and safety of glucose-control strategies using the quadruple drug combination. Therefore, the aim of the present study was to investigate the usefulness of the quadruple combination therapy with oral hypoglycemic agents (OHAs) in patients with uncontrolled type 2 diabetes mellitus (T2DM).

Methods

From March 2014 to December 2018, data of patients with T2DM, who were treated with quadruple hypoglycemic medications for over 12 months in 11 hospitals in South Korea, were reviewed retrospectively. We compared glycosylated hemoglobin (HbA1c) levels before and 12 months after quadruple treatment with OHAs. The safety, maintenance rate, and therapeutic patterns after failure of the quadruple therapy were also evaluated.

Results

In total, 357 patients were enrolled for quadruple OHA therapy, and the baseline HbA1c level was 9.0%±1.3% (74.9±14.1 mmol/mol). After 12 months, 270 patients (75.6%) adhered to the quadruple therapy and HbA1c was significantly reduced from 8.9%±1.2% to 7.8%±1.3% (mean change, −1.1%±1.2%; P<0.001). The number of patients with HbA1c <7% increased significantly from 5 to 68 (P<0.005). In addition, lipid profiles and liver enzyme levels were also improved whereas no changes in body weight. There was no significant safety issue in patients treated with quadruple OHA therapy.

Conclusion

This study shows the therapeutic efficacy of the quadruple OHA regimen T2DM and demonstrates that it can be an option for the management of T2DM patients who cannot use insulin or reject injectable therapy.

Citations

Citations to this article as recorded by  
  • Estimating Type 2 Diabetes Prevalence: A Model of Drug Consumption Data
    Rita Oliveira, Matilde Monteiro-Soares, José Pedro Guerreiro, Rúben Pereira, António Teixeira-Rodrigues
    Pharmacy.2024; 12(1): 18.     CrossRef
  • Disease burden and symptom management in type 2 diabetic patients: A phenomenological study
    Sevgi Demir Çam, Sevda Uzun
    Public Health Nursing.2024;[Epub]     CrossRef
  • Efficacy and safety of enavogliflozin versus dapagliflozin added to metformin plus gemigliptin treatment in patients with type 2 diabetes: A double-blind, randomized, comparator-active study: ENHANCE-D study
    Kyung-Soo Kim, Kyung Ah Han, Tae Nyun Kim, Cheol-Young Park, Jung Hwan Park, Sang Yong Kim, Yong Hyun Kim, Kee Ho Song, Eun Seok Kang, Chul Sik Kim, Gwanpyo Koh, Jun Goo Kang, Mi Kyung Kim, Ji Min Han, Nan Hee Kim, Ji Oh Mok, Jae Hyuk Lee, Soo Lim, Sang S
    Diabetes & Metabolism.2023; 49(4): 101440.     CrossRef
  • Effectiveness and safety of teneligliptin added to patients with type 2 diabetes inadequately controlled by oral triple combination therapy: A multicentre, randomized, double‐blind, and placebo‐controlled study
    Minyoung Lee, Woo‐je Lee, Jae Hyeon Kim, Byung‐Wan Lee
    Diabetes, Obesity and Metabolism.2022; 24(6): 1105.     CrossRef
  • A double‐blind, Randomized controlled trial on glucose‐lowering EFfects and safety of adding 0.25 or 0.5 mg lobeglitazone in type 2 diabetes patients with INadequate control on metformin and dipeptidyl peptidase‐4 inhibitor therapy: REFIND study
    Soree Ryang, Sang Soo Kim, Ji Cheol Bae, Ji Min Han, Su Kyoung Kwon, Young Il Kim, Il Seong Nam‐Goong, Eun Sook Kim, Mi‐kyung Kim, Chang Won Lee, Soyeon Yoo, Gwanpyo Koh, Min Jeong Kwon, Jeong Hyun Park, In Joo Kim
    Diabetes, Obesity and Metabolism.2022; 24(9): 1800.     CrossRef
  • Glycaemic control with add‐on thiazolidinedione or a sodium‐glucose co‐transporter‐2 inhibitor in patients with type 2 diabetes after the failure of an oral triple antidiabetic regimen: A 24‐week, randomized controlled trial
    Jaehyun Bae, Ji Hye Huh, Minyoung Lee, Yong‐Ho Lee, Byung‐Wan Lee
    Diabetes, Obesity and Metabolism.2021; 23(2): 609.     CrossRef
Pathophysiology
Mitochondrial Dysfunction in Adipocytes as a Primary Cause of Adipose Tissue Inflammation
Chang-Yun Woo, Jung Eun Jang, Seung Eun Lee, Eun Hee Koh, Ki-Up Lee
Diabetes Metab J. 2019;43(3):247-256.   Published online March 27, 2019
DOI: https://doi.org/10.4093/dmj.2018.0221
  • 9,775 View
  • 278 Download
  • 74 Web of Science
  • 75 Crossref
AbstractAbstract PDFPubReader   

Adipose tissue inflammation is considered a major contributing factor in the development of obesity-associated insulin resistance and cardiovascular diseases. However, the cause of adipose tissue inflammation is presently unclear. The role of mitochondria in white adipocytes has long been neglected because of their low abundance. However, recent evidence suggests that mitochondria are essential for maintaining metabolic homeostasis in white adipocytes. In a series of recent studies, we found that mitochondrial function in white adipocytes is essential to the synthesis of adiponectin, which is the most abundant adipokine synthesized from adipocytes, with many favorable effects on metabolism, including improvement of insulin sensitivity and reduction of atherosclerotic processes and systemic inflammation. From these results, we propose a new hypothesis that mitochondrial dysfunction in adipocytes is a primary cause of adipose tissue inflammation and compared this hypothesis with a prevailing concept that “adipose tissue hypoxia” may underlie adipose tissue dysfunction in obesity. Recent studies have emphasized the role of the mitochondrial quality control mechanism in maintaining mitochondrial function. Future studies are warranted to test whether an inadequate mitochondrial quality control mechanism is responsible for mitochondrial dysfunction in adipocytes and adipose tissue inflammation.

Citations

Citations to this article as recorded by  
  • Aerobic and Resistance Training Attenuate Differently Knee Joint Damage Caused by a High-Fat–High-Sucrose Diet in a Rat Model
    Nada Abughazaleh, Kevin Boldt, Jaqueline Lourdes Rios, Stela Marcia Mattiello, Kelsey H. Collins, Ruth-Anne Seerattan, Walter Herzog
    CARTILAGE.2024; 15(4): 453.     CrossRef
  • Prolonged Endurance Exercise Increases Macrophage Content and Mitochondrial Respiration in Adipose Tissue in Trained Men
    Ronni Eg Sahl, Ioanna Patsi, Mikkel Thunestvedt Hansen, Tue Rømer, Jacob Frandsen, Hanne Kruuse Rasmusen, Arthur Ingersen, Steen Seier Poulsen, Flemming Dela, Steen Larsen, Jørn Wulff Helge
    The Journal of Clinical Endocrinology & Metabolism.2024; 109(2): e799.     CrossRef
  • Diabetes Mellitus, Energy Metabolism, and COVID-19
    Caterina Conte, Elisa Cipponeri, Michael Roden
    Endocrine Reviews.2024; 45(2): 281.     CrossRef
  • The Role of Ion-Transporting Proteins in Human Disease
    Yoshinori Marunaka
    International Journal of Molecular Sciences.2024; 25(3): 1726.     CrossRef
  • The Role of Obesity in Type 2 Diabetes Mellitus—An Overview
    Preethi Chandrasekaran, Ralf Weiskirchen
    International Journal of Molecular Sciences.2024; 25(3): 1882.     CrossRef
  • The Metabolic Syndrome, a Human Disease
    Marià Alemany
    International Journal of Molecular Sciences.2024; 25(4): 2251.     CrossRef
  • Inflammation‐mediated metabolic regulation in adipose tissue
    Shujie Xu, Feng Lu, Jianhua Gao, Yi Yuan
    Obesity Reviews.2024;[Epub]     CrossRef
  • Sleeve Gastrectomy Reduces Oxidative Stress and Reverses Mitochondrial Dysfunction Associated with Metabolic Syndrome
    Micaela M. Rossi, Franco J. Signorini, Tomas A. Castillo, María P. Scribano Parada, Federico Moser, Maria dC Baez
    Obesity Surgery.2024; 34(6): 2042.     CrossRef
  • The relationships between high-fat diet and metabolic syndrome: Potential mechanisms
    Chao Tang, Yuxin Wang, Zeyu Xu, Dan Chen, Jingguo Xu, Duo Yang, Li Zhang, Jun Liu, Juan Kan
    Food Bioscience.2024; 59: 104261.     CrossRef
  • Obesity, Dietary Patterns, and Hormonal Balance Modulation: Gender-Specific Impacts
    Elisa Mazza, Ersilia Troiano, Yvelise Ferro, Fabrizia Lisso, Martina Tosi, Ettore Turco, Roberta Pujia, Tiziana Montalcini
    Nutrients.2024; 16(11): 1629.     CrossRef
  • Mitochondrial quality control in human health and disease
    Bo-Hao Liu, Chen-Zhen Xu, Yi Liu, Zi-Long Lu, Ting-Lv Fu, Guo-Rui Li, Yu Deng, Guo-Qing Luo, Song Ding, Ning Li, Qing Geng
    Military Medical Research.2024;[Epub]     CrossRef
  • Adalimumab Treatment Effects on Inflammation and Adipose Tissue Mitochondrial Respiration in Hidradenitis Suppurativa
    Ronni Eg Sahl, Axel Illeris Poggi, Valdemar Wendelboe Nielsen, Yiqiu Yao, Ioanna Patsi, Steen Seier Poulsen, Flemming Dela, Steen Larsen, Simon Francis Thomsen, Jørn Wulff Helge
    Endocrinology, Diabetes & Metabolism.2024;[Epub]     CrossRef
  • Dietary vegetable Sarcochlamys pulcherrima Gaud. and its bioactive compound myricitrin promotes white adipose browning in obese models via AMPK/SIRT1/UCP1 upregulation.
    Shalini Gurumayum, Devi Basumatary, Pranamika Sarma, Kangkon Saikia, Deepsikha Swargiary, Semim Ahmed Akhtar, Abhipsha Saikia, Jagat Chandra Borah
    Food Bioscience.2024; : 105292.     CrossRef
  • Could very low-calorie ketogenic diets turn off low grade inflammation in obesity? Emerging evidence
    Luigi Barrea, Massimiliano Caprio, Mikiko Watanabe, Giuseppe Cammarata, Alessandra Feraco, Giovanna Muscogiuri, Ludovica Verde, Annamaria Colao, Silvia Savastano
    Critical Reviews in Food Science and Nutrition.2023; 63(26): 8320.     CrossRef
  • The emergent role of mitochondrial RNA modifications in metabolic alterations
    Hatim Boughanem, Yvonne Böttcher, João Tomé‐Carneiro, María‐Carmen López de las Hazas, Alberto Dávalos, Akin Cayir, Manuel Macias‐González
    WIREs RNA.2023;[Epub]     CrossRef
  • Age‐associated adipose tissue inflammation promotes monocyte chemotaxis and enhances atherosclerosis
    Jianrui Song, Diana Farris, Paola Ariza, Smriti Moorjani, Mita Varghese, Muriel Blin, Judy Chen, Daniel Tyrrell, Min Zhang, Kanakadurga Singer, Morgan Salmon, Daniel R. Goldstein
    Aging Cell.2023;[Epub]     CrossRef
  • Obesity, diabetes mellitus, and cardiometabolic risk: An Obesity Medicine Association (OMA) Clinical Practice Statement (CPS) 2023
    Harold Edward Bays, Shagun Bindlish, Tiffany Lowe Clayton
    Obesity Pillars.2023; 5: 100056.     CrossRef
  • A role of STING signaling in obesity-induced lung inflammation
    Yong Qi, Zhuhua Wu, Dan Chen, Li Zhu, Yunlei Yang
    International Journal of Obesity.2023; 47(4): 325.     CrossRef
  • Estrogens in Adipose Tissue Physiology and Obesity-Related Dysfunction
    Alina Kuryłowicz
    Biomedicines.2023; 11(3): 690.     CrossRef
  • White Adipose Tissue Dysfunction: Pathophysiology and Emergent Measurements
    Natalia Santillana, Camila Astudillo-Guerrero, Amanda D’Espessailles, Gonzalo Cruz
    Nutrients.2023; 15(7): 1722.     CrossRef
  • Pleiotropic and multi-systemic actions of physical exercise on PGC-1α signaling during the aging process
    Ivo Vieira de Sousa Neto, Ana Paula Pinto, Vitor Rosetto Muñoz, Rita de Cássia Marqueti, José Rodrigo Pauli, Eduardo Rochete Ropelle, Adelino Sanchez Ramos da Silva
    Ageing Research Reviews.2023; 87: 101935.     CrossRef
  • The impact of metabolic endotoxaemia on the browning process in human adipocytes
    Farah Omran, Alice M. Murphy, Awais Z. Younis, Ioannis Kyrou, Jana Vrbikova, Vojtech Hainer, Petra Sramkova, Martin Fried, Graham Ball, Gyanendra Tripathi, Sudhesh Kumar, Philip G. McTernan, Mark Christian
    BMC Medicine.2023;[Epub]     CrossRef
  • Molecular Mechanisms of Obesity-Induced Development of Insulin Resistance and Promotion of Amyloid-β Accumulation: Dietary Therapy Using Weak Organic Acids via Improvement of Lowered Interstitial Fluid pH
    Yoshinori Marunaka
    Biomolecules.2023; 13(5): 779.     CrossRef
  • From Obesity-Induced Low-Grade Inflammation to Lipotoxicity and Mitochondrial Dysfunction: Altered Multi-Crosstalk between Adipose Tissue and Metabolically Active Organs
    Gina Cavaliere, Fabiano Cimmino, Giovanna Trinchese, Angela Catapano, Lidia Petrella, Margherita D’Angelo, Lucio Lucchin, Maria Pina Mollica
    Antioxidants.2023; 12(6): 1172.     CrossRef
  • Receptor for the Advanced Glycation End Products (RAGE) Pathway in Adipose Tissue Metabolism
    Klaudia Gutowska, Krzysztof Czajkowski, Alina Kuryłowicz
    International Journal of Molecular Sciences.2023; 24(13): 10982.     CrossRef
  • Exercise mitigates age-related metabolic diseases by improving mitochondrial dysfunction
    Dandan Jia, Zhenjun Tian, Ru Wang
    Ageing Research Reviews.2023; 91: 102087.     CrossRef
  • Mitochondrial dynamics and metabolism across skin cells: implications for skin homeostasis and aging
    Ines Martic, Federica Papaccio, Barbara Bellei, Maria Cavinato
    Frontiers in Physiology.2023;[Epub]     CrossRef
  • Influence of Breastfeeding on the State of Meta-Inflammation in Obesity—A Narrative Review
    Dominika Mazur, Małgorzata Satora, Anna K. Rekowska, Zuzanna Kabała, Aleksandra Łomża, Żaneta Kimber-Trojnar, Bożena Leszczyńska-Gorzelak
    Current Issues in Molecular Biology.2023; 45(11): 9003.     CrossRef
  • AGER-1 Long Non-Coding RNA Levels Correlate with the Expression of the Advanced Glycosylation End-Product Receptor, a Regulator of the Inflammatory Response in Visceral Adipose Tissue of Women with Obesity and Type 2 Diabetes Mellitus
    Klaudia Gutowska, Krzysztof Koźniewski, Michał Wąsowski, Marta Izabela Jonas, Zbigniew Bartoszewicz, Wojciech Lisik, Maurycy Jonas, Artur Binda, Paweł Jaworski, Wiesław Tarnowski, Bartłomiej Noszczyk, Monika Puzianowska-Kuźnicka, Krzysztof Czajkowski, Ali
    International Journal of Molecular Sciences.2023; 24(24): 17447.     CrossRef
  • Pharmacological treatment with FGF21 strongly improves plasma cholesterol metabolism to reduce atherosclerosis
    Cong Liu, Milena Schönke, Enchen Zhou, Zhuang Li, Sander Kooijman, Mariëtte R Boon, Mikael Larsson, Kristina Wallenius, Niek Dekker, Louise Barlind, Xiao-Rong Peng, Yanan Wang, Patrick C N Rensen
    Cardiovascular Research.2022; 118(2): 489.     CrossRef
  • Obesity-Related Adipose Tissue Remodeling in the Light of Extracellular Mitochondria Transfer
    Simon Lecoutre, Karine Clément, Isabelle Dugail
    International Journal of Molecular Sciences.2022; 23(2): 632.     CrossRef
  • IL-4 polarized human macrophage exosomes control cardiometabolic inflammation and diabetes in obesity
    Tuan Anh Phu, Martin Ng, Ngan K. Vu, Laura Bouchareychas, Robert L. Raffai
    Molecular Therapy.2022; 30(6): 2274.     CrossRef
  • Insulin-inducible THRSP maintains mitochondrial function and regulates sphingolipid metabolism in human adipocytes
    Maria A. Ahonen, Marcus Höring, Van Dien Nguyen, Sami Qadri, Juuso H. Taskinen, Meghana Nagaraj, Martin Wabitsch, Pamela Fischer-Posovszky, You Zhou, Gerhard Liebisch, P. A. Nidhina Haridas, Hannele Yki-Järvinen, Vesa M. Olkkonen
    Molecular Medicine.2022;[Epub]     CrossRef
  • Modulation of adipose inflammation by cellular retinoic acid-binding protein 1
    Chin-Wen Wei, Jennifer Nhieu, Yu-Lung Lin, Li-Na Wei
    International Journal of Obesity.2022; 46(10): 1759.     CrossRef
  • The Role of Adipokines in Pancreatic Cancer
    Qi Wang, Huizhi Wang, Yuntao Ding, Mengtian Wan, Min Xu
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Epigenetic Reprogramming of the Inflammatory Response in Obesity and Type 2 Diabetes
    Federica Zatterale, Gregory Alexander Raciti, Immacolata Prevenzano, Alessia Leone, Michele Campitelli, Veronica De Rosa, Francesco Beguinot, Luca Parrillo
    Biomolecules.2022; 12(7): 982.     CrossRef
  • Cellular Metabolism and Bioenergetic Function in Human Fibroblasts and Preadipocytes of Type 2 Familial Partial Lipodystrophy
    Cristina Algieri, Chiara Bernardini, Fabiana Trombetti, Elisa Schena, Augusta Zannoni, Monica Forni, Salvatore Nesci
    International Journal of Molecular Sciences.2022; 23(15): 8659.     CrossRef
  • Shared pathobiology identifies AMPK as a therapeutic target for obesity and autosomal dominant polycystic kidney disease
    Ioan-Andrei Iliuta, Xuewen Song, Lauren Pickel, Amirreza Haghighi, Ravi Retnakaran, James Scholey, Hoon-Ki Sung, Gregory R. Steinberg, York Pei
    Frontiers in Molecular Biosciences.2022;[Epub]     CrossRef
  • Hypoxia as a Double-Edged Sword to Combat Obesity and Comorbidities
    Ruwen Wang, Qin Sun, Xianmin Wu, Yiyin Zhang, Xiaorui Xing, Kaiqing Lin, Yue Feng, Mingqi Wang, Yibing Wang, Ru Wang
    Cells.2022; 11(23): 3735.     CrossRef
  • Macrophage and Adipocyte Mitochondrial Dysfunction in Obesity-Induced Metabolic Diseases
    Liwen Wang, Jie Hu, Haiyan Zhou
    The World Journal of Men's Health.2021; 39(4): 606.     CrossRef
  • ESRRA (estrogen related receptor alpha) is a critical regulator of intestinal homeostasis through activation of autophagic flux via gut microbiota
    Sup Kim, June-Young Lee, Seul Gi Shin, Jin Kyung Kim, Prashanta Silwal, Young Jae Kim, Na-Ri Shin, Pil Soo Kim, Minho Won, Sang-Hee Lee, Soo Yeon Kim, Miwa Sasai, Masahiro Yamamoto, Jin-Man Kim, Jin-Woo Bae, Eun-Kyeong Jo
    Autophagy.2021; 17(10): 2856.     CrossRef
  • GDF15 as a central mediator for integrated stress response and a promising therapeutic molecule for metabolic disorders and NASH
    Kook Hwan Kim, Myung-Shik Lee
    Biochimica et Biophysica Acta (BBA) - General Subjects.2021; 1865(3): 129834.     CrossRef
  • The Influence of Obesity and Associated Fatty Acids on Placental Inflammation
    Alison J. Eastman, Rebecca E. Moore, Steven D. Townsend, Jennifer A. Gaddy, David M. Aronoff
    Clinical Therapeutics.2021; 43(2): 265.     CrossRef
  • Targeting the G protein-coupled estrogen receptor (GPER) in obesity and diabetes
    Geetanjali Sharma, Eric R. Prossnitz
    Endocrine and Metabolic Science.2021; 2: 100080.     CrossRef
  • Changes in Body Composition Are Associated with Metabolic Changes and the Risk of Metabolic Syndrome
    Yun Hwan Oh, Seulggie Choi, Gyeongsil Lee, Joung Sik Son, Kyae Hyung Kim, Sang Min Park
    Journal of Clinical Medicine.2021; 10(4): 745.     CrossRef
  • N6-Adenosine Methylation (m6A) RNA Modification: an Emerging Role in Cardiovascular Diseases
    Ye-shi Chen, Xin-ping Ouyang, Xiao-hua Yu, Petr Novák, Le Zhou, Ping-ping He, Kai Yin
    Journal of Cardiovascular Translational Research.2021; 14(5): 857.     CrossRef
  • From Metabolic Syndrome to Neurological Diseases: Role of Autophagy
    Jessica Maiuolo, Micaela Gliozzi, Vincenzo Musolino, Cristina Carresi, Federica Scarano, Saverio Nucera, Miriam Scicchitano, Francesca Bosco, Stefano Ruga, Maria Caterina Zito, Roberta Macri, Rosamaria Bulotta, Carolina Muscoli, Vincenzo Mollace
    Frontiers in Cell and Developmental Biology.2021;[Epub]     CrossRef
  • Absent Exercise-Induced Improvements in Fat Oxidation in Women With Polycystic Ovary Syndrome After High-Intensity Interval Training
    Sofie Lionett, Ida Almenning Kiel, Ragnhild Røsbjørgen, Stian Lydersen, Steen Larsen, Trine Moholdt
    Frontiers in Physiology.2021;[Epub]     CrossRef
  • Roles of interstitial fluid pH and weak organic acids in development and amelioration of insulin resistance
    Yoshinori Marunaka
    Biochemical Society Transactions.2021; 49(2): 715.     CrossRef
  • The Role of Mitochondrial Adaptation and Metabolic Flexibility in the Pathophysiology of Obesity and Insulin Resistance: an Updated Overview
    Dimitrios Tsilingiris, Evangelia Tzeravini, Chrysi Koliaki, Maria Dalamaga, Alexander Kokkinos
    Current Obesity Reports.2021; 10(3): 191.     CrossRef
  • Obesity-Related Inflammation and Endothelial Dysfunction in COVID-19: Impact on Disease Severity
    Andrea De Lorenzo, Vanessa Estato, Hugo C Castro-Faria-Neto, Eduardo Tibirica
    Journal of Inflammation Research.2021; Volume 14: 2267.     CrossRef
  • Thermogenic Fat: Development, Physiological Function, and Therapeutic Potential
    Bruna B. Brandão, Ankita Poojari, Atefeh Rabiee
    International Journal of Molecular Sciences.2021; 22(11): 5906.     CrossRef
  • Metabolic Syndrome in an Aging Society – Role of Oxidant-Antioxidant Imbalance and Inflammation Markers in Disentangling Atherosclerosis
    Sylwia Dziegielewska-Gesiak
    Clinical Interventions in Aging.2021; Volume 16: 1057.     CrossRef
  • Recruitment and remodeling of peridroplet mitochondria in human adipose tissue
    Rebeca Acín-Perez, Anton Petcherski, Michaela Veliova, Ilan Y. Benador, Essam A. Assali, Georgia Colleluori, Saverio Cinti, Alexandra J. Brownstein, Siyouneh Baghdasarian, Masha J. Livhits, Michael W. Yeh, Karthickeyan Chella Krishnan, Laurent Vergnes, Na
    Redox Biology.2021; 46: 102087.     CrossRef
  • New Insights Into Mitochondrial Dysfunction at Disease Susceptibility Loci in the Development of Type 2 Diabetes
    Hannah Maude, Winston Lau, Nikolas Maniatis, Toby Andrew
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Effects of sleeve gastrectomy on bone mass, microstructure of femurs and bone metabolism associated serum factors in obese rats
    Ying Xue, Ran Li, Yong Zhao, Ling Li, Yun Zhou
    BMC Endocrine Disorders.2021;[Epub]     CrossRef
  • The cyclin dependent kinase inhibitor Roscovitine prevents diet-induced metabolic disruption in obese mice
    Nabil Rabhi, Kathleen Desevin, Briana Noel Cortez, Ryan Hekman, Jean Z. Lin, Andrew Emili, Stephen R. Farmer
    Scientific Reports.2021;[Epub]     CrossRef
  • Reliability and variation in mitochondrial respiration in human adipose tissue
    Ronni Eg Sahl, Eva Frederikke Høy Helms, Malte Schmücker, Mathias Flensted-Jensen, Arthur Ingersen, Thomas Morville, Flemming Dela, Jørn Wulff Helge, Steen Larsen
    Adipocyte.2021; 10(1): 605.     CrossRef
  • Inhibition of protein tyrosine phosphatase improves mitochondrial bioenergetics and dynamics, reduces oxidative stress, and enhances adipogenic differentiation potential in metabolically impaired progenitor stem cells
    Katarzyna Kornicka-Garbowska, Lynda Bourebaba, Michael Röcken, Krzysztof Marycz
    Cell Communication and Signaling.2021;[Epub]     CrossRef
  • microRNAs in Human Adipose Tissue Physiology and Dysfunction
    Alina Kurylowicz
    Cells.2021; 10(12): 3342.     CrossRef
  • Aging, obese-insulin resistance, and bone remodeling
    Napatsorn Imerb, Chanisa Thonusin, Nipon Chattipakorn, Siriporn C. Chattipakorn
    Mechanisms of Ageing and Development.2020; 191: 111335.     CrossRef
  • Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes
    Federica Zatterale, Michele Longo, Jamal Naderi, Gregory Alexander Raciti, Antonella Desiderio, Claudia Miele, Francesco Beguinot
    Frontiers in Physiology.2020;[Epub]     CrossRef
  • Is Mitochondrial Dysfunction a Common Root of Noncommunicable Chronic Diseases?
    Alexis Diaz-Vegas, Pablo Sanchez-Aguilera, James R Krycer, Pablo E Morales, Matías Monsalves-Alvarez, Mariana Cifuentes, Beverly A Rothermel, Sergio Lavandero
    Endocrine Reviews.2020;[Epub]     CrossRef
  • Inflammatory Signaling and Brown Fat Activity
    Farah Omran, Mark Christian
    Frontiers in Endocrinology.2020;[Epub]     CrossRef
  • Omega-3 fatty acids as regulators of brown/beige adipose tissue: from mechanisms to therapeutic potential
    Marta Fernández-Galilea, Elisa Félix-Soriano, Ignacio Colón-Mesa, Xavier Escoté, Maria J. Moreno-Aliaga
    Journal of Physiology and Biochemistry.2020; 76(2): 251.     CrossRef
  • Anti-Inflammatory Strategies Targeting Metaflammation in Type 2 Diabetes
    Alina Kuryłowicz, Krzysztof Koźniewski
    Molecules.2020; 25(9): 2224.     CrossRef
  • Obese Adipose Tissue Secretion Induces Inflammation in Preadipocytes: Role of Toll-Like Receptor-4
    Mariana Renovato-Martins, Catharina Moreira-Nunes, Georgia C. Atella, Christina Barja-Fidalgo, João Alfredo de Moraes
    Nutrients.2020; 12(9): 2828.     CrossRef
  • Diabetes and Metabolism Journal in 2020: Good to Great
    In-Kyung Jeong
    Diabetes & Metabolism Journal.2020; 44(1): 1.     CrossRef
  • The Effect of Silibinin on Protein Expression Profile in White Adipose Tissue of Obese Mice
    Fei Wang, Shuchun Chen, Luping Ren, Yichao Wang, Zelin Li, Tiantian Song, He Zhang, Qiwen Yang
    Frontiers in Pharmacology.2020;[Epub]     CrossRef
  • Beneficial Effects of Bariatric Surgery-Induced by Weight Loss on the Proteome of Abdominal Subcutaneous Adipose Tissue
    Bárbara María Varela-Rodríguez, Paula Juiz-Valiña, Luis Varela, Elena Outeiriño-Blanco, Susana Belén Bravo, María Jesús García-Brao, Enrique Mena, José Francisco Noguera, Javier Valero-Gasalla, Fernando Cordido, Susana Sangiao-Alvarellos
    Journal of Clinical Medicine.2020; 9(1): 213.     CrossRef
  • Impact of Skeletal Muscle Mass on Metabolic Health
    Gyuri Kim, Jae Hyeon Kim
    Endocrinology and Metabolism.2020; 35(1): 1.     CrossRef
  • Sea buckthorn (Hippophae rhamnoides L.) oil enhances proliferation, adipocytes differentiation and insulin sensitivity in 3T3-L1 cells
    Ting Zhang, Xuze Qin, Yuxin Cao, Jianxin Zhang, Junxing Zhao
    Food Science and Biotechnology.2020; 29(11): 1511.     CrossRef
  • Adipose tissue secretory profile and cardiometabolic risk in obesity
    Pengcheng Zhang, Daniels Konja, Yu Wang
    Endocrine and Metabolic Science.2020; 1(3-4): 100061.     CrossRef
  • Mitochondrial Dynamics in the Brain Are Associated With Feeding, Glucose Homeostasis, and Whole-Body Metabolism
    Jessica L. Haigh, Lauryn E. New, Beatrice M. Filippi
    Frontiers in Endocrinology.2020;[Epub]     CrossRef
  • Adipogenesis: A Necessary but Harmful Strategy
    Mohammed El Hafidi, Mabel Buelna-Chontal, Fausto Sánchez-Muñoz, Roxana Carbó
    International Journal of Molecular Sciences.2019; 20(15): 3657.     CrossRef
Obesity and Metabolic Syndrome
Statins Increase Mitochondrial and Peroxisomal Fatty Acid Oxidation in the Liver and Prevent Non-Alcoholic Steatohepatitis in Mice
Han-Sol Park, Jung Eun Jang, Myoung Seok Ko, Sung Hoon Woo, Bum Joong Kim, Hyun Sik Kim, Hye Sun Park, In-Sun Park, Eun Hee Koh, Ki-Up Lee
Diabetes Metab J. 2016;40(5):376-385.   Published online April 5, 2016
DOI: https://doi.org/10.4093/dmj.2016.40.5.376
  • 7,275 View
  • 92 Download
  • 68 Web of Science
  • 129 Crossref
AbstractAbstract PDFPubReader   
Background

Non-alcoholic fatty liver disease is the most common form of chronic liver disease in industrialized countries. Recent studies have highlighted the association between peroxisomal dysfunction and hepatic steatosis. Peroxisomes are intracellular organelles that contribute to several crucial metabolic processes, such as facilitation of mitochondrial fatty acid oxidation (FAO) and removal of reactive oxygen species through catalase or plasmalogen synthesis. Statins are known to prevent hepatic steatosis and non-alcoholic steatohepatitis (NASH), but underlying mechanisms of this prevention are largely unknown.

Methods

Seven-week-old C57BL/6J mice were given normal chow or a methionine- and choline-deficient diet (MCDD) with or without various statins, fluvastatin, pravastatin, simvastatin, atorvastatin, and rosuvastatin (15 mg/kg/day), for 6 weeks. Histological lesions were analyzed by grading and staging systems of NASH. We also measured mitochondrial and peroxisomal FAO in the liver.

Results

Statin treatment prevented the development of MCDD-induced NASH. Both steatosis and inflammation or fibrosis grades were significantly improved by statins compared with MCDD-fed mice. Gene expression levels of peroxisomal proliferator-activated receptor α (PPARα) were decreased by MCDD and recovered by statin treatment. MCDD-induced suppression of mitochondrial and peroxisomal FAO was restored by statins. Each statin's effect on increasing FAO and improving NASH was independent on its effect of decreasing cholesterol levels.

Conclusion

Statins prevented NASH and increased mitochondrial and peroxisomal FAO via induction of PPARα. The ability to increase hepatic FAO is likely the major determinant of NASH prevention by statins. Improvement of peroxisomal function by statins may contribute to the prevention of NASH.

Citations

Citations to this article as recorded by  
  • Organelle stress and alterations in interorganelle crosstalk during liver fibrosis
    Saloni Sinha, Nora Hassan, Robert E. Schwartz
    Hepatology.2024; 79(2): 482.     CrossRef
  • Statin therapy: a potential adjuvant to immunotherapies in hepatocellular carcinoma
    Jiao Wang, Chengyu Liu, Ronghua Hu, Licheng Wu, Chuanzhou Li
    Frontiers in Pharmacology.2024;[Epub]     CrossRef
  • Recent Progress in Anti‐Tumor Nanodrugs Based on Tumor Microenvironment Redox Regulation
    Lan Yao, Xiang Zhu, Yunyi Shan, Liang Zhang, Jing Yao, Hui Xiong
    Small.2024;[Epub]     CrossRef
  • Exploration of the Key Genes Involved in Non-alcoholic Fatty Liver Disease and Possible MicroRNA Therapeutic Targets
    Ali Mahmoudi, Amin Jalili, Alexandra E. Butler, Seyed H. Aghaee-Bakhtiari, Tannaz Jamialahmadi, Amirhossein Sahebkar
    Journal of Clinical and Experimental Hepatology.2024; 14(4): 101365.     CrossRef
  • Inflammation drives pathogenesis of early intestinal failure-associated liver disease
    Scott C. Fligor, Savas T. Tsikis, Thomas I. Hirsch, Ashish Jain, Liang Sun, Shira Rockowitz, Kathleen M. Gura, Mark Puder
    Scientific Reports.2024;[Epub]     CrossRef
  • A Systematic Review of Statins for the Treatment of Nonalcoholic Steatohepatitis: Safety, Efficacy, and Mechanism of Action
    Shiqin Zhang, Xiaoling Ren, Bingzheng Zhang, Tian Lan, Bing Liu
    Molecules.2024; 29(8): 1859.     CrossRef
  • Statins in Chronic Liver Disease: Review of the Literature and Future Role
    Nguyen Pham, Jihane N. Benhammou
    Seminars in Liver Disease.2024; 44(02): 191.     CrossRef
  • Team players in the pathogenesis of metabolic dysfunctions-associated steatotic liver disease: The basis of development of pharmacotherapy
    Shahid Habib
    World Journal of Gastrointestinal Pathophysiology.2024;[Epub]     CrossRef
  • Metabolic dysfunction-associated steatotic liver disease-induced changes in the antioxidant system: a review
    Gabriela Svobodová, Martin Horní, Eva Velecká, Iva Boušová
    Archives of Toxicology.2024;[Epub]     CrossRef
  • Effects of metformin and simvastatin treatment on ultrastructural features of liver macrophages in HFD mice
    Darko Ciric, Tamara Kravic-Stevovic, Vladimir Bumbasirevic, Sasa Petricevic, Sofija Jovanovic, Vladimir Trajkovic, Tamara Martinovic
    Ultrastructural Pathology.2023; 47(1): 1.     CrossRef
  • Statins for the Treatment of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis: A Systematic Review and Meta-Analysis
    Weiwei Dai, Baohong Xu, Peng Li, Junhua Weng
    American Journal of Therapeutics.2023; 30(1): e17.     CrossRef
  • Atorvastatin Attenuates Diet-Induced Non-Alcoholic Steatohepatitis in APOE*3-Leiden Mice by Reducing Hepatic Inflammation
    José A. Inia, Geurt Stokman, Elsbet J. Pieterman, Martine C. Morrison, Aswin L. Menke, Lars Verschuren, Martien P. M. Caspers, Martin Giera, J. Wouter Jukema, Anita M. van den Hoek, Hans M. G. Princen
    International Journal of Molecular Sciences.2023; 24(9): 7818.     CrossRef
  • The interplay between nonalcoholic fatty liver disease and atherosclerotic cardiovascular disease
    Alexandra C. Finney, Sandeep Das, Dhananjay Kumar, M. Peyton McKinney, Bishuang Cai, Arif Yurdagul, Oren Rom
    Frontiers in Cardiovascular Medicine.2023;[Epub]     CrossRef
  • Serum metabolomic signatures of fatty acid oxidation defects differentiate host-response subphenotypes of acute respiratory distress syndrome
    Tomeka L. Suber, Stacy G. Wendell, Steven J. Mullett, Benjamin Zuchelkowski, William Bain, Georgios D. Kitsios, Bryan J. McVerry, Prabir Ray, Anuradha Ray, Rama K. Mallampalli, Yingze Zhang, Faraaz Shah, Seyed Mehdi Nouraie, Janet S. Lee
    Respiratory Research.2023;[Epub]     CrossRef
  • Statins on nonalcoholic fatty liver disease: A systematic review and meta-analysis of 14 RCTs
    Haiyan Zhou, Maeda Toshiyoshi,, Wenli Zhao, Ye Zhao, Yan Zhao,
    Medicine.2023; 102(26): e33981.     CrossRef
  • Atorvastatin rescues hyperhomocysteinemia-induced cognitive deficits and neuroinflammatory gene changes
    Erica M. Weekman, Sherika N. Johnson, Colin B. Rogers, Tiffany L. Sudduth, Kevin Xie, Qi Qiao, David W. Fardo, Teodoro Bottiglieri, Donna M. Wilcock
    Journal of Neuroinflammation.2023;[Epub]     CrossRef
  • Crosstalk between Lipids and Non-Alcoholic Fatty Liver Disease
    Divyavani Gowda, Chandra Shekhar, Siddabasave Gowda B. Gowda, Yifan Chen, Shu-Ping Hui
    Livers.2023; 3(4): 687.     CrossRef
  • Empagliflozin: Potential Protective Effects on Hepatocytes and Liver Outcomes in Streptozotocin -Diabetic Rats.
    Alia Khwaldeh, Nour Al-Sawalha, Shefa' Aljabali, Ziad Shraideh, Sokiyna Ababneh, Roba Bdeir
    Biomedical and Pharmacology Journal.2023; 16(4): 2123.     CrossRef
  • Is there a role of lipid-lowering therapies in the management of fatty liver disease?
    Ismini Tzanaki, Aris P Agouridis, Michael S Kostapanos
    World Journal of Hepatology.2022; 14(1): 119.     CrossRef
  • Bifidobacterium animalis subsp. lactis A6 Enhances Fatty Acid β-Oxidation of Adipose Tissue to Ameliorate the Development of Obesity in Mice
    Yanxiong Huo, Guoping Zhao, Jinwang Li, Ran Wang, Fazheng Ren, Yixuan Li, Xiaoyu Wang
    Nutrients.2022; 14(3): 598.     CrossRef
  • PharmOmics: A species- and tissue-specific drug signature database and gene-network-based drug repositioning tool
    Yen-Wei Chen, Graciel Diamante, Jessica Ding, Thien Xuan Nghiem, Jessica Yang, Sung-Min Ha, Peter Cohn, Douglas Arneson, Montgomery Blencowe, Jennifer Garcia, Nima Zaghari, Paul Patel, Xia Yang
    iScience.2022; 25(4): 104052.     CrossRef
  • Pleyotropic Effects of Statins Non-Alcoholic Fat Disease of the Liver Non-Alcoholic Steatohepatitis
    И.Р. Агабабян, Ш.Ш. Садыкова
    Рецепт.2022; (2): 194.     CrossRef
  • PPAR Alpha as a Metabolic Modulator of the Liver: Role in the Pathogenesis of Nonalcoholic Steatohepatitis (NASH)
    Simona Todisco, Anna Santarsiero, Paolo Convertini, Giulio De Stefano, Michele Gilio, Vito Iacobazzi, Vittoria Infantino
    Biology.2022; 11(5): 792.     CrossRef
  • Association between organochlorine pesticides and nonalcoholic fatty liver disease in the National Health and Nutrition Examination Survey 2003–2004
    Hyunji Sang, Kyu-Na Lee, Chang Hee Jung, Kyungdo Han, Eun Hee Koh
    Scientific Reports.2022;[Epub]     CrossRef
  • Integrating the contributions of mitochondrial oxidative metabolism to lipotoxicity and inflammation in NAFLD pathogenesis
    Curtis C. Hughey, Patrycja Puchalska, Peter A. Crawford
    Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.2022; 1867(11): 159209.     CrossRef
  • Supplementation of Lycium barbarum Polysaccharide Combined with Aerobic Exercise Ameliorates High-Fat-Induced Nonalcoholic Steatohepatitis via AMPK/PPARα/PGC-1α Pathway
    Dou-Dou Li, Jia-Min Ma, Ming-Jing Li, Lu-Lu Gao, Yan-Na Fan, Yan-Nan Zhang, Xiu-Juan Tao, Jian-Jun Yang
    Nutrients.2022; 14(15): 3247.     CrossRef
  • Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH)
    Xiaohan Xu, Kyle L. Poulsen, Lijuan Wu, Shan Liu, Tatsunori Miyata, Qiaoling Song, Qingda Wei, Chenyang Zhao, Chunhua Lin, Jinbo Yang
    Signal Transduction and Targeted Therapy.2022;[Epub]     CrossRef
  • Regulation of Hepatic Lipid and Glucose Metabolism by INSP3R1
    Rachel J. Perry
    Diabetes.2022; 71(9): 1834.     CrossRef
  • Effects of SLCO1B1 Genetic Variant on Metabolite Profile in Participants on Simvastatin Treatment
    Lilian Fernandes Silva, Rowmika Ravi, Jagadish Vangipurapu, Anniina Oravilahti, Markku Laakso
    Metabolites.2022; 12(12): 1159.     CrossRef
  • Acute and chronic effects of environmental realistic concentrations of simvastatin in danio rerio: evidences of oxidative alterations and endocrine disruptive activity
    D. Rebelo, A.T. Correia, B. Nunes
    Environmental Toxicology and Pharmacology.2021; 81: 103522.     CrossRef
  • Allopurinol ameliorates high fructose diet induced hepatic steatosis in diabetic rats through modulation of lipid metabolism, inflammation, and ER stress pathway
    In-Jin Cho, Da-Hee Oh, Jin Yoo, You-Cheol Hwang, Kyu Jeung Ahn, Ho-Yeon Chung, Soung Won Jeong, Ju-Young Moon, Sang-Ho Lee, Sung-Jig Lim, In-Kyung Jeong
    Scientific Reports.2021;[Epub]     CrossRef
  • Atorvastatin Modulates Bile Acid Homeostasis in Mice with Diet-Induced Nonalcoholic Steatohepatitis
    Hana Lastuvkova, Fatemeh Alaei Faradonbeh, Jolana Schreiberova, Milos Hroch, Jaroslav Mokry, Hana Faistova, Zuzana Nova, Radomír Hyspler, Ivone Cristina Igreja Sa, Petr Nachtigal, Alzbeta Stefela, Petr Pavek, Stanislav Micuda
    International Journal of Molecular Sciences.2021; 22(12): 6468.     CrossRef
  • PPARs as Metabolic Sensors and Therapeutic Targets in Liver Diseases
    Hugo Christian Monroy-Ramirez, Marina Galicia-Moreno, Ana Sandoval-Rodriguez, Alejandra Meza-Rios, Arturo Santos, Juan Armendariz-Borunda
    International Journal of Molecular Sciences.2021; 22(15): 8298.     CrossRef
  • Simvastatin affects the PPARα signaling pathway and causes oxidative stress and embryonic development interference in Mugilogobius abei
    Chao Wang, Tianli Tang, Yimeng Wang, Xiangping Nie, Kaibin Li
    Aquatic Toxicology.2021; 239: 105951.     CrossRef
  • Impact of statin use on the risk and prognosis of hepatocellular carcinoma: a meta-analysis
    Jianfeng Wang, Xiaogang Li
    European Journal of Gastroenterology & Hepatology.2021; 33(12): 1603.     CrossRef
  • Statins in Non-alcoholic Steatohepatitis
    Jose D. Torres-Peña, Laura Martín-Piedra, Francisco Fuentes-Jiménez
    Frontiers in Cardiovascular Medicine.2021;[Epub]     CrossRef
  • Comparison of the liver findings after simvastatin-treatment between Spontaneously Diabetic Torii-Leprfa (SDT fatty) rats and Sprague-Dawley rats
    Tadakazu Takahashi, Yusuke Suzuki, Naohito Yamada, Kaoru Toyoda, Keisuke Goda, Katsunori Ryoke, Chizuru Matsuura, Akio Kobayashi, Shoichiro Sugai, Kayoko Shimoi
    Fundamental Toxicological Sciences.2020; 7(1): 41.     CrossRef
  • Current and emerging pharmacotherapeutic interventions for the treatment of liver fibrosis
    Joeri Lambrecht, Leo A. van Grunsven, Frank Tacke
    Expert Opinion on Pharmacotherapy.2020; 21(13): 1637.     CrossRef
  • The Influence of Statins on the Aerobic Metabolism of Endothelial Cells
    Izabela Broniarek, Karolina Dominiak, Lukasz Galganski, Wieslawa Jarmuszkiewicz
    International Journal of Molecular Sciences.2020; 21(4): 1485.     CrossRef
  • NADPH Oxidase Inhibition in Fibrotic Pathologies
    Karen Bernard, Victor J. Thannickal
    Antioxidants & Redox Signaling.2020; 33(6): 455.     CrossRef
  • Pleiotropic Effects of Statins in the Light of Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis
    Farah Ahsan, Federico Oliveri, Harshit K Goud, Zainab Mehkari, Lubna Mohammed, Moiz Javed, Aldanah Althwanay, Ian H Rutkofsky
    Cureus.2020;[Epub]     CrossRef
  • Peroxisomal footprint in the pathogenesis of nonalcoholic steatohepatitis
    S.M. Touhidul Islam, Jeseong Won, Mushfiquddin Khan, Kenneth D. Chavin, Inderjit Singh
    Annals of Hepatology.2020; 19(5): 466.     CrossRef
  • Structural Basis for Activation of Human Sirtuin 6 by Fluvastatin
    Weijie You, Clemens Steegborn
    ACS Medicinal Chemistry Letters.2020; 11(11): 2285.     CrossRef
  • Specificity of transaminase activities in the prediction of drug-induced hepatotoxicity
    Akio Kobayashi, Yusuke Suzuki, Shoichiro Sugai
    The Journal of Toxicological Sciences.2020; 45(9): 515.     CrossRef
  • Disease-associated gut microbiome and metabolome changes in patients with chronic obstructive pulmonary disease
    Kate L. Bowerman, Saima Firdous Rehman, Annalicia Vaughan, Nancy Lachner, Kurtis F. Budden, Richard Y. Kim, David L. A. Wood, Shaan L. Gellatly, Shakti D. Shukla, Lisa G. Wood, Ian A. Yang, Peter A. Wark, Philip Hugenholtz, Philip M. Hansbro
    Nature Communications.2020;[Epub]     CrossRef
  • Simvastatin Reduces Hepatic Oxidative Stress and Endoplasmic Reticulum Stress in Nonalcoholic Steatohepatitis Experimental Model
    Graziella Rodrigues, Andrea Janz Moreira, Silvia Bona, Elizângela Schemitt, Cláudio Augusto Marroni, Fábio Cangeri Di Naso, Alexandre Simões Dias, Thienne Rocha Pires, Jaqueline Nascimento Picada, Norma Possa Marroni
    Oxidative Medicine and Cellular Longevity.2019; 2019: 1.     CrossRef
  • Impaired Peroxisomal Fitness in Obese Mice, a Vicious Cycle Exacerbating Adipocyte Dysfunction via Oxidative Stress
    Lingjuan Piao, Debra Dorotea, Songling Jiang, Eun Hee Koh, Goo Taeg Oh, Hunjoo Ha
    Antioxidants & Redox Signaling.2019; 31(18): 1339.     CrossRef
  • (5R)-5-hydroxytriptolide ameliorates liver lipid accumulation by suppressing lipid synthesis and promoting lipid oxidation in mice
    Yunxia Dong, Henglei Lu, Qiang Li, Xinming Qi, Yuanchao Li, Zean Zhang, Jing Chen, Jin Ren
    Life Sciences.2019; 232: 116644.     CrossRef
  • Simvastatin alleviates bone resorption in apical periodontitis possibly by inhibition of mitophagy‐related osteoblast apoptosis
    C.‐N. Yang, S.‐H. Kok, H.‐W. Wang, J. Z.‐C. Chang, E. H.‐H. Lai, C.‐T. Shun, H. Yang, M.‐H. Chen, C.‐Y. Hong, S.‐K. Lin
    International Endodontic Journal.2019; 52(5): 676.     CrossRef
  • Different Effects of Pravastatin on Preeclampsia-like Symptoms in Different Mouse Models
    Jing Huai, Zi Yang, Yan-Hong Yi, Guang-Jiao Wang
    Chinese Medical Journal.2018; 131(4): 461.     CrossRef
  • Ameliorating effects of D-47, a newly developed compound, on lipid metabolism in an animal model of familial hypercholesterolemia (WHHLMI rabbits)
    Shohei Tamura, Yui Koike, Hiroaki Takeda, Tomonari Koike, Yoshihiro Izumi, Ryosuke Nagasaka, Tetsuto Tsunoda, Motoo Tori, Kazuo Ogawa, Takeshi Bamba, Masashi Shiomi
    European Journal of Pharmacology.2018; 822: 147.     CrossRef
  • Fluvastatin activates sirtuin 6 to regulate sterol regulatory element-binding proteins and AMP-activated protein kinase in HepG2 cells
    Ji-Hye Kim, Jun Mi Lee, Jong-Hoon Kim, Kwang Rok Kim
    Biochemical and Biophysical Research Communications.2018; 503(3): 1415.     CrossRef
  • Statin use and the risk of hepatocellular carcinoma in patients at high risk: A nationwide nested case-control study
    Gyuri Kim, Suk-Yong Jang, Chung Mo Nam, Eun Seok Kang
    Journal of Hepatology.2018; 68(3): 476.     CrossRef
  • Membrane Remodeling as a Key Player of the Hepatotoxicity Induced by Co-Exposure to Benzo[a]pyrene and Ethanol of Obese Zebrafish Larvae
    Muhammad Imran, Odile Sergent, Arnaud Tête, Isabelle Gallais, Martine Chevanne, Dominique Lagadic-Gossmann, Normand Podechard
    Biomolecules.2018; 8(2): 26.     CrossRef
  • Corticosterone-Induced Lipogenesis Activation and Lipophagy Inhibition in Chicken Liver Are Alleviated by Maternal Betaine Supplementation
    Yun Hu, Qinwei Sun, Yan Hu, Zhen Hou, Yibo Zong, Nagmeldin A Omer, Halima Abobaker, Ruqian Zhao
    The Journal of Nutrition.2018; 148(3): 316.     CrossRef
  • Simvastatin protects against acetaminophen-induced liver injury in mice
    Huan Liang, Yang Feng, Ruixia Cui, Minglong Qiu, Jingyao Zhang, Chang Liu
    Biomedicine & Pharmacotherapy.2018; 98: 916.     CrossRef
  • Effects of Pitavastatin on Insulin Sensitivity and Liver Fat: A Randomized Clinical Trial
    Laurie R Braun, Meghan N Feldpausch, Natalia Czerwonka, Julian Weiss, Karen Branch, Hang Lee, Edgar L Martinez-Salazar, Martin Torriani, Craig A Sponseller, Steven K Grinspoon, Takara L Stanley
    The Journal of Clinical Endocrinology & Metabolism.2018; 103(11): 4176.     CrossRef
  • Inactivation of SREBP-1a Phosphorylation Prevents Fatty Liver Disease in Mice: Identification of Related Signaling Pathways by Gene Expression Profiles in Liver and Proteomes of Peroxisomes
    Birgit Knebel, Sonja Hartwig, Sylvia Jacob, Ulrike Kettel, Martina Schiller, Waltraud Passlack, Cornelia Koellmer, Stefan Lehr, Dirk Müller-Wieland, Jorg Kotzka
    International Journal of Molecular Sciences.2018; 19(4): 980.     CrossRef
  • MicroRNA-124 Regulates Fatty Acid and Triglyceride Homeostasis
    Tyler A. Shaw, Ragunath Singaravelu, Megan H. Powdrill, Jordan Nhan, Nadine Ahmed, Dennis Özcelik, John Paul Pezacki
    iScience.2018; 10: 149.     CrossRef
  • Liver Disease in Singapore
    Mark Muthiah, Chern H Chong, Seng G Lim
    Euroasian Journal of Hepato-Gastroenterology.2018; 8(1): 66.     CrossRef
  • Accelerating Treatment of Skeletal Class II Malocclusion using Fixed Twin Block Appliances
    Snigdha Pattanaik, Navya Puvvula, Noorjahan Mohammad
    International Journal of Clinical Pediatric Dentistry.2018; 11(2): 146.     CrossRef
  • Effect of a Papain-based Chemomechanical Agent on Structure of Dentin and Bond Strength: Anin vitroStudy
    Veena S Pai, Yashwanth Gowda, Sruthi Nair
    International Journal of Clinical Pediatric Dentistry.2018; 11(3): 161.     CrossRef
  • Perception of Indian Dental Surgeons regarding Molar Incisor Hypomineralization
    Sumita Upadhyay, Jatinder K Dhillon
    International Journal of Clinical Pediatric Dentistry.2018; 11(2): 116.     CrossRef
  • Association between Obesity and Oral Health Status in Schoolchildren: A Survey in Five Districts of West Bengal, India
    Rahul Kaul, Paras Angrish, Subrata Saha, Sonali Halder, Bhaswar Bhattacharya, Malay Mitra
    International Journal of Clinical Pediatric Dentistry.2018; 11(3): 233.     CrossRef
  • Burden of Alcoholic Liver Disease: Bhutan Scenario
    Pelden Wangchuk
    Euroasian Journal of Hepato-Gastroenterology.2018; 8(1): 81.     CrossRef
  • Comparative Evaluation of Effects ofTriphala, Garlic Extracts, and Chlorhexidine Mouthwashes on SalivaryStreptococcus mutansCounts and Oral Hygiene Status
    Shweta Gupta, Narendra Padiyar, Bharathi Padiyar
    International Journal of Clinical Pediatric Dentistry.2018; 11(4): 299.     CrossRef
  • Evaluation of Dentin–Pulp Complex Response after Conservative Clinical Procedures in Primary Teeth
    Thais Marchini Oliveira, Bianca Mello, Tassia C Stafuzza, Luciana Vitor, Daniela Rios, Thiago Silva, Maria Machado
    International Journal of Clinical Pediatric Dentistry.2018; 11(3): 188.     CrossRef
  • Nonalcoholic Fatty Liver Disease: Time to Take the Bull by the Horns
    Preetam Nath, Shivaram P Singh
    Euroasian Journal of Hepato-Gastroenterology.2018; 8(1): 47.     CrossRef
  • F-18 Fluorodeoxyglucose Positron Emission Tomography/ Computed Tomography Findings of Isolated Gastric Tuberculosis mimicking Gastric Cancer and Lymphoma
    Remzi A Akdogan, Halil Rakici, Serkan Güngör, Recep Bedir, Elif Akdogan
    Euroasian Journal of Hepato-Gastroenterology.2018; 8(1): 93.     CrossRef
  • Clinical, Radiological, and Histological Assessment of Magnetic Nanoparticles as Pulpotomy Medicament in Primary Molars
    Manoj K Mallela, Harivinder R Konyala, Ajay R Mareddy, N Venugopal Reddy, Keerthi P Susheela
    International Journal of Clinical Pediatric Dentistry.2018; 11(4): 283.     CrossRef
  • Determination of ABO Blood Groups and Rh Typing from Dry Salivary Samples
    Laxmi Lakade, Priyam R Velani
    International Journal of Clinical Pediatric Dentistry.2018; 11(2): 100.     CrossRef
  • Orofacial Manifestations of Leukemic Children on Treatment: A Descriptive Study
    Keerthilatha M Pai, Aparna Aggarwal
    International Journal of Clinical Pediatric Dentistry.2018; 11(3): 193.     CrossRef
  • Mandibular Regional Odontodysplasia in an 8-year-old Boy showing Teeth Disorders, Gubernaculum Tracts, and Altered Bone Fractal Pattern
    Davi de Sá Cavalcante, Cristiane SR Fonteles, Thyciana R Ribeiro, Lúcio M Kurita, Alynne Vde M Pimenta, Francisco SR Carvalho, Fábio WG Costa
    International Journal of Clinical Pediatric Dentistry.2018; 11(2): 128.     CrossRef
  • Evaluation of Chemokines in the Gingival Crevicular Fluid of Children with Down Syndrome
    Harshini Togaru, Veerakishore Kumar Reddy, Naveen K Kommineni, Prathyusha Padakandla, John P Indupalli, Swapna P Nanga
    International Journal of Clinical Pediatric Dentistry.2018; 11(4): 288.     CrossRef
  • Hepatitis B Virus Infection among Health Care Workers in Indonesia
    David H Muljono, Teguh Wijayadi, Rizalinda Sjahril
    Euroasian Journal of Hepato-Gastroenterology.2018; 8(1): 88.     CrossRef
  • Comparison of the Effectiveness of Probiotic, Chlorhexidine-based Mouthwashes, and Oil Pulling Therapy on Plaque Accumulation and Gingival Inflammation in 10- to 12-year-old Schoolchildren: A Randomized Controlled Trial
    Saravana K Kandaswamy, Asokan Sharath, PR Geetha Priya
    International Journal of Clinical Pediatric Dentistry.2018; 11(2): 66.     CrossRef
  • Evaluation of Changes in Salivary pH after Intake of Different Eatables and Beverages in Children at Different Time Intervals
    Ankit Pachori, Haalaswamy Kambalimath, Garima Bhambhani, Garima Malhotra
    International Journal of Clinical Pediatric Dentistry.2018; 11(3): 177.     CrossRef
  • Customized Hybrid Bluegrass Appliance: An Innovative Technique
    Ziauddin Mohammad, Apeksha Bagalkotkar, Ashank Mishra, Gopi Veerala
    International Journal of Clinical Pediatric Dentistry.2018; 11(2): 141.     CrossRef
  • Postobstructive Cyst Formation in Pancreatic Duct affecting Surgical Approach
    Alper Parlakgumus, Ali Ezer
    Euroasian Journal of Hepato-Gastroenterology.2018; 8(1): 99.     CrossRef
  • Validating the Usage of Cariogram in 5- and 12-year-old School-going Children in Paonta Sahib, Himachal Pradesh, India: A 12-month Prospective Study
    Manish Madan, Pallav Singhal, Anu Garg, Akash Dupper
    International Journal of Clinical Pediatric Dentistry.2018; 11(2): 110.     CrossRef
  • Epidemiology of Chronic Hepatitis B in Turkey
    Hasan Ozkan
    Euroasian Journal of Hepato-Gastroenterology.2018; 8(1): 73.     CrossRef
  • A Comparative Evaluation of Time-dependent Changes on the Surface Hardness of Bulk Cure Composites: Anin vitroStudy
    Anindita Sarma
    International Journal of Clinical Pediatric Dentistry.2018; 11(3): 183.     CrossRef
  • Management of Hepatocellular Carcinoma: Bangladesh Perspective
    Mohammad Noor-E-Alam
    Euroasian Journal of Hepato-Gastroenterology.2018; 8(1): 52.     CrossRef
  • Trichobezoar: Ravenous for Hair
    Aman Kamra
    Euroasian Journal of Hepato-Gastroenterology.2018; 8(1): 97.     CrossRef
  • Comparative Evaluation of the Fracture Resistance of Two Different Fiber-reinforced Composite Restorations with Particulate Filler Composite Restorations
    Vanga V Narasimha Rao, Srinivas K Chandrabhatla, Vabbala R Rajasekhar
    International Journal of Clinical Pediatric Dentistry.2018; 11(4): 277.     CrossRef
  • A Comparative Evaluation of Efficacy ofStreptococcus mutansCounts in Saliva: Anin vivoStudy
    Inder K Pandit
    International Journal of Clinical Pediatric Dentistry.2018; 11(2): 94.     CrossRef
  • Liver Cancer in Nepal
    Ananta Shrestha
    Euroasian Journal of Hepato-Gastroenterology.2018; 8(1): 63.     CrossRef
  • Pre-eruptive Intracoronal Radiolucency in First Permanent Molar
    Mariana C Ilha, Paulo F Kramer, Simone H Ferreira, Henrique C Ruschel
    International Journal of Clinical Pediatric Dentistry.2018; 11(2): 151.     CrossRef
  • Comparative Evaluation of Various Temperature Changes on Stress Distribution in Class II Mesial-occlusal-distal Preparation restored with Different Restorative Materials: A Finite Element Analysis
    Binita Srivastava, Neorem N Devi
    International Journal of Clinical Pediatric Dentistry.2018; 11(3): 167.     CrossRef
  • A Survey on the Use of Antibiotics among the Dentists of Kolkata, West Bengal, India
    Rahul Kaul, Paras Angrish, Subrata Saha, Ashok V Sengupta, Shantanu Mukherjee
    International Journal of Clinical Pediatric Dentistry.2018; 11(2): 122.     CrossRef
  • Changing Etiology in Liver Cirrhosis in Sapporo, Japan
    Jong-Hon Kang, Takeshi Matsui
    Euroasian Journal of Hepato-Gastroenterology.2018; 8(1): 77.     CrossRef
  • Epidemiology, Genotype Distribution, Prognosis, Control, and Management of Viral Hepatitis B, C, D, and Hepatocellular Carcinoma in Mongolia
    Oidov Baatarkhuu, Tsagaantsooj Gerelchimeg, Dashchirev Munkh-Orshikh, Badamnachin Batsukh, Ganbold Sarangua, Jazag Amarsanaa
    Euroasian Journal of Hepato-Gastroenterology.2018; 8(1): 57.     CrossRef
  • Impact of Diabetes Mellitus Type 1 on Lebanese Families’ Quality of Life
    Nahla Nassif, Balsam Noueiri
    International Journal of Clinical Pediatric Dentistry.2018; 11(2): 61.     CrossRef
  • Pediatric Dental Appointments No-show: Rates and Reasons
    Anup Panda, Rupinder Bhatia, Esha C Vora
    International Journal of Clinical Pediatric Dentistry.2018; 11(3): 171.     CrossRef
  • A Case of Painless Excision
    Rupinder Bhatia, Ipshita A Suyash
    International Journal of Clinical Pediatric Dentistry.2018; 11(2): 135.     CrossRef
  • Manuka Honey: A Potent Cariostatic Agent–Anin vitroStudy
    Sapna Konde, Javaregowda P Beena, Punyatoya Sahoo, N Sunil Raj, Narayana C Kumar
    International Journal of Clinical Pediatric Dentistry.2018; 11(2): 105.     CrossRef
  • Reviewing of Research Finding of Hepatitis B Virus Infection in Lao People's Democratic Republic
    Angkham Ounavong
    Euroasian Journal of Hepato-Gastroenterology.2018; 8(1): 75.     CrossRef
  • Nonalcoholic Fatty Liver Disease: Identifying the Disease Burden in Sri Lanka
    Anuradha S Dassanayake
    Euroasian Journal of Hepato-Gastroenterology.2018; 8(1): 69.     CrossRef
  • Comparative Evaluation of Microhardness by Common Drinks on Esthetic Restorative Materials and Enamel: Anin vitroStudy
    Manish Madan, Akash Dupper, Roli Gupta, Trilok Kainthla
    International Journal of Clinical Pediatric Dentistry.2018; 11(3): 155.     CrossRef
  • Hepatocellular Carcinoma Surveillance: Benefit of Serum Alfa-fetoprotein in Real-world Practice
    Patharapan Lersritwimanmaen, Supot Nimanong
    Euroasian Journal of Hepato-Gastroenterology.2018; 8(1): 83.     CrossRef
  • Body Mass Index and Dental Caries: A Systematic Review

    International Journal of Clinical Pediatric Dentistry.2018; 11(3): 228.     CrossRef
  • Evaluation of Surgical Options for Supernumerary Teeth in the Anterior Maxilla
    Gianluca Porcaro, Luca Mirabelli, Ernesto Amosso
    International Journal of Clinical Pediatric Dentistry.2018; 11(4): 294.     CrossRef
  • A Comparative Study to evaluate Parent's Ability to assess Dental Fear in their 6- to 10-year-old Children using Children's Fear Survey Schedule—Dental Subscale
    Ritika Malhotra, Anchal Sahni
    International Journal of Clinical Pediatric Dentistry.2018; 11(3): 205.     CrossRef
  • Estimation of Salivary Glucose, Calcium, Phosphorus, Alkaline Phosphatase, and Immunoglobulin A among Diabetic and Nondiabetic Children: A Case–Control Study
    Kalyani Uppu, Suzan Sahana, Ghanashyam P Madu, Aron AK Vasa, Sowjanya Nalluri
    International Journal of Clinical Pediatric Dentistry.2018; 11(2): 71.     CrossRef
  • Pedodontic Considerations in a Child with Attention Deficit Hyperactivity Disorder: Literature Review and a Case Report
    Siddhi Sinha, Prasanna Praveen, S Prathibha Rani, Athimuthu Anantharaj
    International Journal of Clinical Pediatric Dentistry.2018; 11(3): 254.     CrossRef
  • Salivary Cortisol and Alpha-amylase—Biomarkers of Stress in Children undergoing Extraction: Anin vivoStudy
    Neha Agarwal, Shefali Chaturvedy, Saurabh Chaturvedi, Yogita Chaturvedi
    International Journal of Clinical Pediatric Dentistry.2018; 11(3): 214.     CrossRef
  • Influence of Storage Media and Duration of Fragment in the Media on the Bond Strength of the Reattached Tooth Fragment
    Prashant Jalannavar
    International Journal of Clinical Pediatric Dentistry.2018; 11(2): 83.     CrossRef
  • Comparative Evaluation of Mucosal Vibrator with Topical Anesthetic Gel to reduce Pain during Administration of Local Anesthesia in Pediatric Patients: Anin vivoStudy
    Mahima Gandhi, Garima Kalia, Khushboo Rathore
    International Journal of Clinical Pediatric Dentistry.2018; 11(4): 261.     CrossRef
  • Management of Autistic Patients in Dental Office: A Clinical Update
    Jyothi S Bommangoudar
    International Journal of Clinical Pediatric Dentistry.2018; 11(3): 219.     CrossRef
  • Foreign Body causing Displacement of Immature Fractured Apical Root Fragment: An Unusual Case Report
    Aman Moda, Rajesh Singla, Preeti M Agrawal
    International Journal of Clinical Pediatric Dentistry.2018; 11(3): 247.     CrossRef
  • Validity and Reliability of the Hindi Version of the Modified Child Perceptions Questionnaire 11 to 14
    Mohit Sharma, Prasanna Kumar, Dempsy CM Mandanna
    International Journal of Clinical Pediatric Dentistry.2018; 11(4): 271.     CrossRef
  • Nonsyndromic Gingival Fibromatosis: A Rare Case Report
    Mahima Gandhi, Akshat Vijay
    International Journal of Clinical Pediatric Dentistry.2018; 11(3): 250.     CrossRef
  • Prevalence of Deleterious Oral Habits among 3- to 5-yearold Preschool Children in Bhubaneswar, Odisha, India
    Brahmananda Dutta, Tulika Verma
    International Journal of Clinical Pediatric Dentistry.2018; 11(3): 210.     CrossRef
  • Evaluation of Antimicrobial Activity of Two Endodontic Sealers: Zinc Oxide with Thyme Oil and Zinc Oxide Eugenol against Root Canal Microorganisms—Anin vitroStudy
    Manoj Chandak, Nilima Thosar, Silpi Basak
    International Journal of Clinical Pediatric Dentistry.2018; 11(2): 79.     CrossRef
  • Prevalence and Risk Factors for Dental Caries among Preschool Children: A Cross-sectional Study in Eastern India
    Vinay K Chugh, Kushal K Sahu, Ankita Chugh
    International Journal of Clinical Pediatric Dentistry.2018; 11(3): 238.     CrossRef
  • Squamous Papilloma on Hard Palate: Case Report and Literature Review
    Penmatsa Chaitanya, Satyam Martha, Ramachandran Punithvathy, Madhusudhan Reddy
    International Journal of Clinical Pediatric Dentistry.2018; 11(3): 244.     CrossRef
  • Comparison of Vitamin D Level of Children with Severe Early Childhood Caries and Children with No Caries
    Anchal Chhonkar, Vishal Arya
    International Journal of Clinical Pediatric Dentistry.2018; 11(3): 199.     CrossRef
  • Use of “Surface Analyzer” to evaluate the Effect of Two Polishing Systems on Surface Texture of Four Newer Composites
    Shefally Garg, Munish Goel, Shweta Verma, Nanika Mahajan, Bhawna Kaul, Vikas Garg
    International Journal of Clinical Pediatric Dentistry.2018; 11(4): 266.     CrossRef
  • Clinical Evaluation of Preventive Effect of Fissure Sealants on Initial Carious Lesion of Permanent Mandibular Molars Pretreated with and without Fluoride Varnish by Fluorescence Camera
    Madhagudanahalli S Lakshmi, Kudlapur T Srilatha, Bhojraj Nandlal, Seema Deshmukh
    International Journal of Clinical Pediatric Dentistry.2018; 11(2): 89.     CrossRef
  • Hepatocellular Carcinoma in Malaysia and Its Changing Trend
    Rosmawati Mohamed, Ruksana Raihan, Amirah Azzeri, Fatiha H Shabaruddin
    Euroasian Journal of Hepato-Gastroenterology.2018; 8(1): 54.     CrossRef
  • Advances in the Understanding and Treatment of Mitochondrial Fatty Acid Oxidation Disorders
    Eric S. Goetzman
    Current Genetic Medicine Reports.2017; 5(3): 132.     CrossRef
  • Hepatokines: linking nonalcoholic fatty liver disease and insulin resistance
    Ruth C. R. Meex, Matthew J. Watt
    Nature Reviews Endocrinology.2017; 13(9): 509.     CrossRef
  • In ovo injection of betaine alleviates corticosterone-induced fatty liver in chickens through epigenetic modifications
    Yun Hu, Qinwei Sun, Jie Liu, Yimin Jia, Demin Cai, Abdulrahman A. Idriss, Nagmeldin A. Omer, Ruqian Zhao
    Scientific Reports.2017;[Epub]     CrossRef
  • The therapeutic effect of silymarin in the treatment of nonalcoholic fatty disease
    Sheng Zhong, Yuxiang Fan, Qi Yan, Xingyu Fan, Bo Wu, Yujuan Han, Ying Zhang, Yong Chen, Huimao Zhang, Junqi Niu
    Medicine.2017; 96(49): e9061.     CrossRef
  • Atorvastatin reduces lipid accumulation in the liver by activating protein kinase A-mediated phosphorylation of perilipin 5
    Xing Gao, Yang Nan, Yuanlin Zhao, Yuan Yuan, Bincheng Ren, Chao Sun, Kaiyu Cao, Ming Yu, Xuyang Feng, Jing Ye
    Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.2017; 1862(12): 1512.     CrossRef
  • Aerobic capacity mediates susceptibility for the transition from steatosis to steatohepatitis
    E. Matthew Morris, Colin S. McCoin, Julie A. Allen, Michelle L. Gastecki, Lauren G. Koch, Steven L. Britton, Justin A. Fletcher, Xiarong Fu, Wen‐Xing Ding, Shawn C. Burgess, R. Scott Rector, John P. Thyfault
    The Journal of Physiology.2017; 595(14): 4909.     CrossRef
  • Use of Statins in Patients with Chronic Liver Disease and Cirrhosis: Current Views and Prospects
    Jose Ignacio Vargas, Marco Arrese, Vijay H. Shah, Juan Pablo Arab
    Current Gastroenterology Reports.2017;[Epub]     CrossRef
  • Endogenous catalase delays high-fat diet-induced liver injury in mice
    Lingjuan Piao, Jiyeon Choi, Guideock Kwon, Hunjoo Ha
    The Korean Journal of Physiology & Pharmacology.2017; 21(3): 317.     CrossRef
  • Clinical implications of understanding the association between oxidative stress and pediatric NAFLD
    Jake P. Mann, Massimiliano Raponi, Valerio Nobili
    Expert Review of Gastroenterology & Hepatology.2017; 11(4): 371.     CrossRef
Complications
Serum Total Bilirubin Levels Provide Additive Risk Information over the Framingham Risk Score for Identifying Asymptomatic Diabetic Patients at Higher Risk for Coronary Artery Stenosis
Jaechan Leem, Eun Hee Koh, Jung Eun Jang, Chang-Yun Woo, Jin Sun Oh, Min Jung Lee, Joon-Won Kang, Tae-Hwan Lim, Chang Hee Jung, Woo Je Lee, Joong-Yeol Park, Ki-Up Lee
Diabetes Metab J. 2015;39(5):414-423.   Published online October 22, 2015
DOI: https://doi.org/10.4093/dmj.2015.39.5.414
  • 4,912 View
  • 45 Download
  • 9 Web of Science
  • 9 Crossref
AbstractAbstract PDFPubReader   
Background

The diagnosis of coronary artery disease (CAD) is often delayed in patients with type 2 diabetes. Serum total bilirubin levels are inversely associated with CAD. However, no studies have examined whether this can be used as a biochemical marker for identifying asymptomatic diabetic patients at higher risk for having obstructive CAD.

Methods

We performed a cross-sectional study of 460 consecutive asymptomatic patients with type 2 diabetes. All patients underwent coronary computed tomographic angiography, and their serum total bilirubin levels were measured. Obstructive CAD was defined as ≥50% diameter stenosis in at least one coronary artery.

Results

Serum total bilirubin tertiles showed an inverse association with the prevalence of obstructive CAD. In multivariate logistic regression analysis, the odds ratio for the highest versus the lowest tertile of total bilirubin was 0.227 (95% confidence interval [CI], 0.130 to 0.398), and an increment of 1 µmol/L in serum total bilirubin level was associated with a 14.6% decrease in obstructive CAD after adjustment for confounding variables. Receiver operating characteristic curve analysis showed that the area under the curve for the Framingham Risk Score (FRS) plus serum total bilirubin level was 0.712 (95% CI, 0.668 to 0.753), which is significantly greater than that of the FRS alone (P=0.0028).

Conclusion

Serum total bilirubin level is inversely associated with obstructive CAD and provides additive risk information over the FRS. Serum total bilirubin may be helpful for identifying asymptomatic patients with type 2 diabetes who are at higher risk for obstructive CAD.

Citations

Citations to this article as recorded by  
  • Association between bilirubin and biomarkers of metabolic health and oxidative stress in the MARK-AGE cohort
    Vanessa Schoissengeier, Lina Maqboul, Daniela Weber, Tilman Grune, Alexander Bürkle, Maria Moreno-Villaneuva, Claudio Franceschi, Miriam Capri, Jürgen Bernhard, Olivier Toussaint, Florence Debacq-Chainiaux, Birgit Weinberger, Efstathios S. Gonos, Ewa Siko
    iScience.2024; 27(7): 110234.     CrossRef
  • Nanoparticle-driven biosensors for diagnosis of viral hepatitis
    Chenggong Zhu, Zhen Xun, Ruijie Fu, Qunfang Huang, Qishui Ou, Yunlei Xianyu, Can Liu
    TrAC Trends in Analytical Chemistry.2024; 180: 117985.     CrossRef
  • DECREASE IN SERUM BILIRUBIN AS AN UNFAVORABLE MARKER OF CARDIOVASCULAR DISORDERS
    L. M. Strilchuk, O. O. Zimba, I. B. Zhakun
    Eastern Ukrainian Medical Journal.2020; 8(3): 268.     CrossRef
  • Contemporary diagnostic algorithm for coronary artery disease: achievements and prospects
    A. S. Akselrod, D. Yu. Shchekochikhin, E. S. Tebenkova, A. V. Zhelankin, D. A. Stonogina, E. A. Syrkina, S. K. Ternovoy
    Kardiologiya i serdechno-sosudistaya khirurgiya.2019; 12(5): 418.     CrossRef
  • Pharmacological actions and therapeutic potentials of bilirubin in islet transplantation for the treatment of diabetes
    Qing Yao, Xue Jiang, Longfa Kou, Adelaide T. Samuriwo, He-Lin Xu, Ying-Zheng Zhao
    Pharmacological Research.2019; 145: 104256.     CrossRef
  • Evaluation of genetic effect of NOS3 and G×E interaction on the variability of serum bilirubin in a Han Chinese population
    Yingshui Yao, Zhengmei Fang, Song Yang, Hailong Zhao, Yanchun Chen, Yuelong Jin, Xianghai Zhao, Lijun Zhu, Yuanrui Tian, Chong Shen
    Nitric Oxide.2017; 70: 25.     CrossRef
  • Supplementation with Phycocyanobilin, Citrulline, Taurine, and Supranutritional Doses of Folic Acid and Biotin—Potential for Preventing or Slowing the Progression of Diabetic Complications
    Mark McCarty
    Healthcare.2017; 5(1): 15.     CrossRef
  • Effect of bilirubin concentration on the risk of diabetic complications: A meta-analysis of epidemiologic studies
    Bo Zhu, Xiaomei Wu, Yifei Bi, Yang Yang
    Scientific Reports.2017;[Epub]     CrossRef
  • Role of Bilirubin in Diabetic Vascular Complications: Can Bilirubin Predict More than Just Liver Disease?
    Jun Sung Moon
    Diabetes & Metabolism Journal.2015; 39(5): 384.     CrossRef
Serum Ceruloplasmin Level as a Predictor for the Progression of Diabetic Nephropathy in Korean Men with Type 2 Diabetes Mellitus
Min Jung Lee, Chang Hee Jung, Yu Mi Kang, Jung Eun Jang, Jaechan Leem, Joong-Yeol Park, Woo Je Lee
Diabetes Metab J. 2015;39(3):230-239.   Published online April 22, 2015
DOI: https://doi.org/10.4093/dmj.2015.39.3.230
  • 5,259 View
  • 57 Download
  • 25 Web of Science
  • 26 Crossref
AbstractAbstract PDFPubReader   
Background

Oxidative stress is known to be associated with progression of diabetic kidney disease. Ceruloplasmin acts as a pro-oxidant under conditions of severe oxidative stress. Thus, we conducted a longitudinal observational study to evaluate whether the serum ceruloplasmin level is a predictive biomarker for progression of diabetic nephropathy.

Methods

A total of 643 Korean men with type 2 diabetes mellitus were enrolled. Serum ceruloplasmin was measured using a nephelometric method. Progression of diabetic nephropathy was defined as transition in albuminuria class (i.e., normoalbuminuria to microalbuminuria, microalbuminuria to macroalbuminuria, or normoalbuminuria to macroalbuminuria) and/or a greater than 2-fold increase of serum creatinine at follow-up compared with the baseline value.

Results

During the follow-up period (median, 2.7 years; range, 0.3 to 4.4 years), 49 of 643 patients (7.6%) showed the progression of diabetic nephropathy and three patients (0.5%) developed end-stage renal disease. Baseline ceruloplasmin levels were higher in the progressors than in the nonprogressors (262.6±40.9 mg/L vs. 233.3±37.8 mg/L, P<0.001). Kaplan-Meier analysis showed a significantly higher incidence of nephropathy progression according to ceruloplasmin tertile (log-rank test, P<0.001). The hazard ratio (HR) for progression of diabetic nephropathy was significantly higher in the highest ceruloplasmin tertile category compared with the lowest ceruloplasmin tertile category, even after adjusting for confounding variables (HR, 3.32; 95% confidence interval, 1.28 to 8.61; P=0.003).

Conclusion

Baseline serum ceruloplasmin is an independent predictive factor for the progression of diabetic nephropathy in patients with type 2 diabetes mellitus.

Citations

Citations to this article as recorded by  
  • Proteomic analysis of urinary exosomes reveals ferroptosis-associated proteins are involved in diabetic nephropathy
    Kaida Mu, Yanping Yang, Xiaofei An, Jie Zhu, Jing Zhang, Yanfei Jiang, Xiaorong Yang, Jinan Zhang
    Genes & Diseases.2024; 11(5): 101138.     CrossRef
  • Modulatory role of Annona squamosa extract against streptozotocin-induced diabetic nephropathy in male rats
    Ghaliah Almalki, Norah Alothman, Gamal Mohamed, Mohammed Akeel, Abd El-Fattah B.M. El-Beltagy, Eman T. Salem
    Egyptian Journal of Basic and Applied Sciences.2024; 11(1): 536.     CrossRef
  • WITHDRAWN: Research on Traditional Chinese Medicine Syndrome Animal Models and Multi-omics Biomarkers in Type II Diabetes: A Review
    Yifei Wang, Yan Gao, Bonian Zhao
    Pharmacological Research - Modern Chinese Medicine.2024; : 100471.     CrossRef
  • Key biomarkers in type 2 diabetes patients: A systematic review
    Thien Ngoc Le, Richard Bright, Vi‐Khanh Truong, Jordan Li, Rajiv Juneja, Krasimir Vasilev
    Diabetes, Obesity and Metabolism.2024;[Epub]     CrossRef
  • In-depth urinary and exosome proteome profiling analysis identifies novel biomarkers for diabetic kidney disease
    Shichun Du, Linhui Zhai, Shu Ye, Le Wang, Muyin Liu, Minjia Tan
    Science China Life Sciences.2023; 66(11): 2587.     CrossRef
  • Serum Level of Ceruloplasmin, Angiotensin-Converting Enzyme and Transferrin as Markers of Severity in SARS-CoV-2 Infection in Patients with Type 2 Diabetes
    Patricia-Andrada Reștea, Ștefan Țigan, Laura Grațiela Vicaș, Luminița Fritea, Eleonora Marian, Tunde Jurca, Annamaria Pallag, Iulius Liviu Mureșan, Corina Moisa, Otilia Micle, Mariana Eugenia Mureșan
    Microbiology Research.2023; 14(4): 1670.     CrossRef
  • The nephropathy of sickle cell trait and sickle cell disease
    Kenneth I. Ataga, Santosh L. Saraf, Vimal K. Derebail
    Nature Reviews Nephrology.2022; 18(6): 361.     CrossRef
  • Integrated Analysis of Single-Cell RNA-seq and Bulk RNA-seq in the Identification of a Novel ceRNA Network and Key Biomarkers in Diabetic Kidney Disease
    Yuejun Wang, Mingming Zhao, Yu Zhang
    International Journal of General Medicine.2022; Volume 15: 1985.     CrossRef
  • Molecular Functions of Ceruloplasmin in Metabolic Disease Pathology
    Zhidong Liu, Miao Wang, Chunbo Zhang, Shigao Zhou, Guang Ji
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2022; Volume 15: 695.     CrossRef
  • A correlative study of copper, ceruloplasmin, iron, total iron binding capacity and total antioxidant capacity in diabetic nephropathy
    Ramlingareddy, Shivashankara A Ramachandrayya, Jeena Jacob, Malathi Mala
    Biomedicine.2022; 42(3): 469.     CrossRef
  • Novel biomarkers for prognosticating diabetic kidney disease progression
    Shilna Muttickal Swaminathan, Indu Ramachandra Rao, Srinivas Vinayak Shenoy, Attur Ravindra Prabhu, Pooja Basthi Mohan, Dharshan Rangaswamy, Mohan V Bhojaraja, Shivashankara Kaniyoor Nagri, Shankar Prasad Nagaraju
    International Urology and Nephrology.2022; 55(4): 913.     CrossRef
  • Evaluation of Serum Ceruloplasmin Levels as a Biomarker for Oxidative Stress in Patients With Diabetic Retinopathy
    Gurunadh Satyanarayana, Narendra Keisham, Hitender S Batra, Subrahmanya Murti V, Mansur Khan, Sandeep Gupta, Vikram Mahindra
    Cureus.2021;[Epub]     CrossRef
  • Prospection of plasma proteins as biomarkers for diabetes mellitus monitoring
    Liliane de Paula Silva, Fabiane Gomes de Moraes Rego, Geraldo Picheth, Marcelo Müller-Santos, Dayane Alberton
    Journal of Diabetes & Metabolic Disorders.2021; 20(1): 611.     CrossRef
  • Risk assessment for foot ulcers among Tunisian subjects with diabetes: a cross sectional outpatient study
    B. Zantour, S. Bouchareb, Z. El Ati, F. Boubaker, W. Alaya, W. Kossomtini, M. H. Sfar
    BMC Endocrine Disorders.2020;[Epub]     CrossRef
  • Metalloproteins and apolipoprotein C: candidate plasma biomarkers of T2DM screened by comparative proteomics and lipidomics in ZDF rats
    Shuai Wang, Zhiyuan Lu, Yuxin Wang, Tianran Zhang, Xiaodong He
    Nutrition & Metabolism.2020;[Epub]     CrossRef
  • Emerging vistas on electrochemical detection of diabetic retinopathy biomarkers
    K.S. Shalini Devi, Madhurantakam Sasya, Uma Maheswari Krishnan
    TrAC Trends in Analytical Chemistry.2020; 125: 115838.     CrossRef
  • Oxidative stress in peritoneal dialysis patients: Association with the dialysis adequacy and technique survival
    Natalia Stepanova, Lesya Korol, Olena Burdeyna
    Indian Journal of Nephrology.2019; 29(5): 309.     CrossRef
  • Recent advancements in biopolymer and metal nanoparticle-based materials in diabetic wound healing management
    Veena Vijayakumar, Sushanta K. Samal, Smita Mohanty, Sanjay K. Nayak
    International Journal of Biological Macromolecules.2019; 122: 137.     CrossRef
  • Rat Böbrek Dokusunda Kurşunun Neden Olduğu Oksidatif Strese Karşı Kitosanın Koruyucu etkisi
    Ugur ÖZDEK, Hasan TOZ, Ahmet Ufuk KÖMÜROĞLU, Leyla MİS, Zübeyir HUYUT, Yeter DEĞER
    Van Veterinary Journal.2019; 30(3): 187.     CrossRef
  • Changes in Trace Elements During Early Stages of Chronic Kidney Disease in Type 2 Diabetic Patients
    Ching-Chiang Lin, Ching-Tang Shih, Chien-Hung Lee, Yeou-Lih Huang
    Biological Trace Element Research.2018; 186(2): 330.     CrossRef
  • The Divalent Elements Changes in Early Stages of Chronic Kidney Disease
    Wan-Ju Kung, Ching-Tang Shih, Chien-Hung Lee, Ching-Chiang Lin
    Biological Trace Element Research.2018; 185(1): 30.     CrossRef
  • Long-term expression of glomerular genes in diabetic nephropathy
    Dominik Chittka, Bernhard Banas, Laura Lennartz, Franz Josef Putz, Kathrin Eidenschink, Sebastian Beck, Thomas Stempfl, Christoph Moehle, Simone Reichelt-Wurm, Miriam C Banas
    Nephrology Dialysis Transplantation.2018;[Epub]     CrossRef
  • Incidence of chronic kidney disease among people with diabetes: a systematic review of observational studies
    D. N. Koye, J. E. Shaw, C. M. Reid, R. C. Atkins, A. T. Reutens, D. J. Magliano
    Diabetic Medicine.2017; 34(7): 887.     CrossRef
  • Global epidemiology of diabetic foot ulceration: a systematic review and meta-analysis
    Pengzi Zhang, Jing Lu, Yali Jing, Sunyinyan Tang, Dalong Zhu, Yan Bi
    Annals of Medicine.2017; 49(2): 106.     CrossRef
  • Biomarkers of diabetic nephropathy: A 2017 update
    Nektaria Papadopoulou-Marketou, Christina Kanaka-Gantenbein, Nikolaos Marketos, George P. Chrousos, Ioannis Papassotiriou
    Critical Reviews in Clinical Laboratory Sciences.2017; 54(5): 326.     CrossRef
  • Serum Vascular Adhesion Protein-1 Predicts End-Stage Renal Disease in Patients with Type 2 Diabetes
    Hung-Yuan Li, Hung-An Lin, Feng-Jung Nien, Vin-Cent Wu, Yi-Der Jiang, Tien-Jyun Chang, Hsien-Li Kao, Mao-Shin Lin, Jung-Nan Wei, Cheng-Hsin Lin, Shyang-Rong Shih, Chi-Sheng Hung, Lee-Ming Chuang, Emmanuel A Burdmann
    PLOS ONE.2016; 11(2): e0147981.     CrossRef
Clinical Features and Causes of Endogenous Hyperinsulinemic Hypoglycemia in Korea
Chang-Yun Woo, Ji Yun Jeong, Jung Eun Jang, Jaechan Leem, Chang Hee Jung, Eun Hee Koh, Woo Je Lee, Min-Seon Kim, Joong-Yeol Park, Jung Bok Lee, Ki-Up Lee
Diabetes Metab J. 2015;39(2):126-131.   Published online March 9, 2015
DOI: https://doi.org/10.4093/dmj.2015.39.2.126
  • 6,074 View
  • 91 Download
  • 23 Web of Science
  • 20 Crossref
AbstractAbstract PDFPubReader   
Background

Endogenous hyperinsulinemic hypoglycemia (EHH) is characterized by an inappropriately high plasma insulin level, despite a low plasma glucose level. Most of the EHH cases are caused by insulinoma, whereas nesidioblastosis and insulin autoimmune syndrome (IAS) are relatively rare.

Methods

To evaluate the relative frequencies of various causes of EHH in Korea, we retrospectively analyzed 84 patients who were diagnosed with EHH from 1998 to 2012 in a university hospital.

Results

Among the 84 EHH patients, 74 patients (88%), five (6%), and five (6%) were diagnosed with insulinoma, nesidioblastosis or IAS, respectively. The most common clinical manifestation of EHH was neuroglycopenic symptoms. Symptom duration before diagnosis was 14.5 months (range, 1 to 120 months) for insulinoma, 1.0 months (range, 6 days to 7 months) for nesidioblastosis, and 2.0 months (range, 1 to 12 months) for IAS. One patient, who was diagnosed with nesidioblastosis in 2006, underwent distal pancreatectomy but was later determined to be positive for insulin autoantibodies. Except for one patient who was diagnosed in 2007, the remaining three patients with nesidioblastosis demonstrated severe hyperinsulinemia (157 to 2,719 µIU/mL), which suggests that these patients might have had IAS, rather than nesidioblastosis.

Conclusion

The results of this study suggest that the prevalence of IAS may be higher in Korea than previously thought. Therefore, measurement of insulin autoantibody levels is warranted for EHH patients, especially in patients with very high plasma insulin levels.

Citations

Citations to this article as recorded by  
  • Case report: Insulinomatosis: description of four sporadic cases and review of the literature
    Delmar Muniz Lourenço, Maria Lucia Corrêa-Giannella, Sheila Aparecida Coelho Siqueira, Marcia Nery, Flavio Galvão Ribeiro, Elizangela Pereira de Souza Quedas, Manoel de Souza Rocha, Ramon Marcelino do Nascimento, Maria Adelaide Albergaria Pereira
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • Use of Translational Science, Continuous Glucose Monitoring in the Primary Care Setting for Management of Nesidioblastosis: A Case Report and Literature Review
    Karuna Manandhar, Othman Farahneh, Ahmad Damlakhy, Ali Lattouf, Gerardo Munoz Monaco
    Cureus.2024;[Epub]     CrossRef
  • Insulin Autoimmune Syndrome: A Systematic Review
    MingXu Lin, YuHua Chen, Jie Ning, Tatsuya Kin
    International Journal of Endocrinology.2023; 2023: 1.     CrossRef
  • Diffuse, Adult-Onset Nesidioblastosis/Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome (NIPHS): Review of the Literature of a Rare Cause of Hyperinsulinemic Hypoglycemia
    Martin Philipp Dieterle, Ayman Husari, Sophie Nicole Prozmann, Hendrik Wiethoff, Albrecht Stenzinger, Manuel Röhrich, Uwe Pfeiffer, Wolfgang Rüdiger Kießling, Helena Engel, Harald Sourij, Thorsten Steinberg, Pascal Tomakidi, Stefan Kopf, Julia Szendroedi
    Biomedicines.2023; 11(6): 1732.     CrossRef
  • An Uncommon Cause of Recurrent Presyncope, Dizziness, and Tachycardia: A Case Report of Diffuse, Adult-Onset Nesidioblastosis/Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome (NIPHS)
    Martin Philipp Dieterle, Ayman Husari, Sophie Nicole Prozmann, Hendrik Wiethoff, Albrecht Stenzinger, Manuel Röhrich, Uwe Pfeiffer, Wolfgang Rüdiger Kießling, Helena Engel, Harald Sourij, Thorsten Steinberg, Pascal Tomakidi, Stefan Kopf, Julia Szendroedi
    Biomedicines.2023; 11(6): 1741.     CrossRef
  • An Uncommon Case of Recurrent Hypoglycemic Episodes in a Healthy Non-diabetic Male: Insulin Autoimmune Syndrome
    Kanwarpal K Dhaliwal, Gaurav Bector, Saurabh Arora, Amanpreet Singh, Sanjay Kalra
    Cureus.2023;[Epub]     CrossRef
  • The After-Dinner Dip
    Caren G. Solomon, Gertrud L.G. Haverkamp, Richard G. Ijzerman, Jos Kooter, Yvonne H.M. Krul-Poel
    New England Journal of Medicine.2022; 386(22): 2130.     CrossRef
  • Hirata's disease (insulin autoimmune syndrome) following envenomation by a common krait
    Subramanian Senthilkumaran, Stephen W. Miller, Harry F. Williams, Ponniah Thirumalaikolundusubramanian, Sakthivel Vaiyapuri, Ketan Patel
    Toxicon.2022; 219: 106923.     CrossRef
  • Analysis of the clinical characteristics of insulin autoimmune syndrome induced by methimazole
    Linli Sun, Weijin Fang, Dan Yi, Wei Sun, Chunjiang Wang
    Journal of Clinical Pharmacy and Therapeutics.2021; 46(2): 470.     CrossRef
  • Continuous glucose monitoring and Rituximab treatment in insulin autoimmune syndrome
    Hiya Boro, Uttio Gupta, Charandeep Singh, Rakhi Malhotra, Rajesh Khadgawat
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2021; 15(6): 102294.     CrossRef
  • Insulin Autoimmune Syndrome (Hirata Disease): A Comprehensive Review Fifty Years After Its First Description


    Daniele Cappellani, Enrico Macchia, Alberto Falorni, Piero Marchetti
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2020; Volume 13: 963.     CrossRef
  • Nationwide survey of endogenous hyperinsulinemic hypoglycemia in Japan (2017–2018): Congenital hyperinsulinism, insulinoma, non‐insulinoma pancreatogenous hypoglycemia syndrome and insulin autoimmune syndrome (Hirata’s disease)
    Yuki Yamada, Kana Kitayama, Maki Oyachi, Shinji Higuchi, Rie Kawakita, Yutaka Kanamori, Tohru Yorifuji
    Journal of Diabetes Investigation.2020; 11(3): 554.     CrossRef
  • Insulin Autoimmune Syndrome – A Case Series
    Hiya Boro, Uttio Gupta, Charandeep Singh, Rakhi Malhotra, Rajesh Khadgawat
    European Endocrinology.2020; 16(2): 168.     CrossRef
  • Management of Insulin Autoimmune Hypoglycaemia: Single‐centre experience from Western India with systematic review of world literature
    Muniraj Patel, Ravikumar Shah, Swati Ramteke‐Jadhav, Virendra Patil, Shivendra Kumar Patel, Anurag Lila, Nalini Shah, Tushar Bandgar
    Clinical Endocrinology.2020; 92(5): 409.     CrossRef
  • Is insulin intoxication still the perfect crime? Analysis and interpretation of postmortem insulin: review and perspectives in forensic toxicology
    Charline Bottinelli, Nathalie Cartiser, Fabien Bévalot, Laurent Fanton, Jérôme Guitton
    Critical Reviews in Toxicology.2020; 50(4): 324.     CrossRef
  • Insulin autoimmune syndrome induced by exogenous insulin injection: a four-case series
    Yimin Shen, Xiaoxiao Song, Yuezhong Ren
    BMC Endocrine Disorders.2019;[Epub]     CrossRef
  • An observational analysis of insulinoma from a single institution
    S Shao, Z Zeng, S Hu
    QJM: An International Journal of Medicine.2018; 111(4): 237.     CrossRef
  • Anti-tuberculosis Treatment-Induced Insulin Autoimmune Syndrome
    Jung Suk Han, Han Ju Moon, Jin Seo Kim, Hong Il Kim, Cheol Hyeon Kim, Min Joo Kim
    The Ewha Medical Journal.2016; 39(4): 122.     CrossRef
  • Spontaneous hypoglycemia: diagnostic evaluation and management
    Leelavathy Kandaswamy, Rajeev Raghavan, Joseph M. Pappachan
    Endocrine.2016; 53(1): 47.     CrossRef
  • Hypoglycemia due to Insulin Autoimmune Syndrome: A rare cause not to be forgotten
    Sarah Alam, Maaz Ozair, Jamal Ahmad
    Journal of Clinical and Translational Endocrinology: Case Reports.2016; 2: 7.     CrossRef
A Novel Therapeutic Agent for Type 2 Diabetes Mellitus: SGLT2 Inhibitor
Chang Hee Jung, Jung Eun Jang, Joong-Yeol Park
Diabetes Metab J. 2014;38(4):261-273.   Published online August 20, 2014
DOI: https://doi.org/10.4093/dmj.2014.38.4.261
  • 8,530 View
  • 161 Download
  • 64 Web of Science
  • 60 Crossref
AbstractAbstract PDFPubReader   

Type 2 diabetes mellitus (T2DM) is a complex endocrine and metabolic disorder, and a major public health problem that is rapidly increasing in prevalence. Although a wide range of pharmacotherapies for glycemic control is now available, management of T2DM remains complex and challenging. The kidneys contribute immensely to glucose homeostasis by reabsorbing glucose from the glomerular filtrate. Sodium-glucose cotransporter 2 (SGLT2) inhibitors, a new class of antidiabetic agents that inhibit glucose absorption from the kidney independent of insulin, offer a unique opportunity to improve the outcomes of patients with T2DM. In this review, we provide an overview of two globally-approved SGLT2 inhibitors, dapagliflozin and canagliflozin, and discuss their effects and safety. This information will help clinicians to decide whether these drugs will benefit their patients.

Citations

Citations to this article as recorded by  
  • Clinical outcomes with the use of sodium-glucose cotransporter-2 inhibitors in patients with atrial fibrillation and type 2 diabetes mellitus: a multi-centre, real-world cohort study
    Jaehyuk Jang, Soyoon Park, Soohyun Kim, Sung-Hwan Kim, Yong-Seog Oh, Young Kyoung Sa, Youmi Hwang, Sung-Won Jang, Sang-Hyun Ihm, Young Choi
    European Journal of Preventive Cardiology.2024; 31(3): 320.     CrossRef
  • Quantitative analysis of low-content impurity crystal forms in canagliflozin tablets by NIR solid-state analysis technique
    Mingdi Liu, Jichao Liu, Qiuhong Wang, Ping Song, Haichao Li, Zan Sun, Chenglong Shi, Weibing Dong
    Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy.2024; 311: 124000.     CrossRef
  • A Randomized Crossover Trial of Mixed Meal Tolerance Test Response in People with Type 1 Diabetes on Insulin Pump Therapy and YG1699 or Dapagliflozin
    Pablo Lapuerta, Silvia Urbina, Jiaojuan He, Alyssa Wittle, Chenghai Li, Tong Li, Helen Wang, Marcus Hompesch
    Clinical Pharmacology & Therapeutics.2024; 115(6): 1383.     CrossRef
  • Ketoacidosis and SGLT2 Inhibitors: A Narrative Review
    Carmela Morace, Giuseppe Lorello, Federica Bellone, Cristina Quartarone, Domenica Ruggeri, Annalisa Giandalia, Giuseppe Mandraffino, Letteria Minutoli, Giovanni Squadrito, Giuseppina T. Russo, Herbert Ryan Marini
    Metabolites.2024; 14(5): 264.     CrossRef
  • Comparison of the effects of empagliflozin and sitagliptin, as add-on to metformin, on serum levels of asprosin and metabolic parameters in patients with type 2 diabetes mellitus
    Seyed Saman Talebi, Shabnam Rezaie, Minoo Sadat Hajmiri, Maryam Zamanirafe, Akram Ranjbar, Heresh Moridi, Mahtabalsadat Mirjalili, Maryam Mehrpooya
    Naunyn-Schmiedeberg's Archives of Pharmacology.2024; 397(11): 9149.     CrossRef
  • Canagliflozin independently reduced plasma volume from conventional diuretics in patients with type 2 diabetes and chronic heart failure: a subanalysis of the CANDLE trial
    Kazuki Shiina, Hirofumi Tomiyama, Atsushi Tanaka, Takumi Imai, Itaru Hisauchi, Isao Taguchi, Akira Sezai, Shigeru Toyoda, Kaoru Dohi, Haruo Kamiya, Keisuke Kida, Toshihisa Anzai, Taishiro Chikamori, Koichi Node, Masayoshi Ajioka, Junya Ako, Rie Amano, Mit
    Hypertension Research.2023; 46(2): 495.     CrossRef
  • Ecofriendly appraisal of stability‐indicating high‐performance chromatographic assay of canagliflozin and metformin with their toxic impurities; in silico toxicity prediction
    Raghda A. Emam, Aml A. Emam
    Journal of Separation Science.2023;[Epub]     CrossRef
  • Effect of sodium‐glucose cotransporter 2 inhibitors on the rate of decline in kidney function: A systematic review and meta‐analysis
    Yanbei Duo, Junxiang Gao, Tao Yuan, Weigang Zhao
    Journal of Diabetes.2023; 15(1): 58.     CrossRef
  • Quantitative analysis of low content polymorphic impurities in canagliflozin tablets by PXRD, NIR, ATR-FITR and Raman solid-state analysis techniques combined with stoichiometry
    Mingdi Liu, Jichao Liu, Qiuhong Wang, Ping Song, Haichao Li, Songgu Wu, Junbo Gong
    Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy.2023; 293: 122458.     CrossRef
  • SGLT2 Inhibitors vs. GLP-1 Agonists to Treat the Heart, the Kidneys and the Brain
    Bartosz Rolek, Mateusz Haber, Magdalena Gajewska, Sylwester Rogula, Arkadiusz Pietrasik, Aleksandra Gąsecka
    Journal of Cardiovascular Development and Disease.2023; 10(8): 322.     CrossRef
  • Cardiorenal Protections of SGLT2 Inhibitors in the Treatment of Type 2 Diabetes
    Somayeh Nazari, Hossein Mirkhani
    Current Diabetes Reviews.2023;[Epub]     CrossRef
  • Efficacy and Safety of Evogliptin Add-on Therapy to Dapagliflozin/Metformin Combinations in Patients with Poorly Controlled Type 2 Diabetes Mellitus: A 24-Week Multicenter Randomized Placebo-Controlled Parallel-Design Phase-3 Trial with a 28-Week Extensio
    Jun Sung Moon, Il Rae Park, Hae Jin Kim, Choon Hee Chung, Kyu Chang Won, Kyung Ah Han, Cheol-Young Park, Jong Chul Won, Dong Jun Kim, Gwan Pyo Koh, Eun Sook Kim, Jae Myung Yu, Eun-Gyoung Hong, Chang Beom Lee, Kun-Ho Yoon
    Diabetes & Metabolism Journal.2023; 47(6): 808.     CrossRef
  • Novel perspective on cardiovascular adverse event profiles due to treatment with sodium-glucose transport protein 2 (SGLT2) inhibitors in the Japanese Adverse Drug Event Report (JADER) database
    Koji Suematsu
    Personalized Medicine Universe.2023; 12: 23.     CrossRef
  • The fate of flavonoids after oral administration: a comprehensive overview of its bioavailability
    Abid Naeem, Yang Ming, Hu Pengyi, Kang Yong Jie, Liu Yali, Zhang Haiyan, Xiao Shuai, Li Wenjing, Wu Ling, Zhang Ming Xia, Liu Shan Shan, Zheng Qin
    Critical Reviews in Food Science and Nutrition.2022; 62(22): 6169.     CrossRef
  • Add-on therapy with dapagliflozin in routine outpatient care of type 2 diabetes patients from Turkey: a retrospective cohort study on HbA1c, body weight, and blood pressure outcomes
    Derun Taner Ertugrul, Erdal Kan, Cigdem Bahadir Tura, Haci Bayram Tugtekin, Hayati Ayakta, Mehmet Celebioglu, Ceren Yılmaz, Onur Utebay, Ilhan Yetkin, Eren Gurkan, Kerem Sezer, Ramazan Gen, Suleyman Ozcaylak, Yildiz Okuturlar, Mehmet Coskun, Nilgun Govec
    International Journal of Diabetes in Developing Countries.2022; 42(1): 147.     CrossRef
  • Sodium–glucose cotransporter 2 inhibitors do not increase the risk of fractures in real‐world clinical practice in Korea: A national observational cohort study
    Kyoung Hwa Ha, Dae Jung Kim, Yong Jun Choi
    Journal of Diabetes Investigation.2022; 13(6): 986.     CrossRef
  • Luseogliflozin preserves the pancreatic beta-cell mass and function in db/db mice by improving mitochondrial function
    Yuki Yamauchi, Akinobu Nakamura, Takashi Yokota, Kiyohiko Takahashi, Shinichiro Kawata, Kazuhisa Tsuchida, Kazuno Omori, Hiroshi Nomoto, Hiraku Kameda, Kyu Yong Cho, Toshihisa Anzai, Shinya Tanaka, Yasuo Terauchi, Hideaki Miyoshi, Tatsuya Atsumi
    Scientific Reports.2022;[Epub]     CrossRef
  • Blood glucose levels and bodyweight change after dapagliflozin administration
    Hyunah Kim, Seung‐Hwan Lee, Hyunyong Lee, Hyeon Woo Yim, Jae‐Hyoung Cho, Kun‐Ho Yoon, Hun‐Sung Kim
    Journal of Diabetes Investigation.2021; 12(9): 1594.     CrossRef
  • Dapagliflozin Improves Cardiac Hemodynamics and Mitigates Arrhythmogenesis in Mitral Regurgitation‐Induced Myocardial Dysfunction
    Yu‐Wen Lin, Chin‐Yu Chen, Jhih‐Yuan Shih, Bor‐Chih Cheng, Ching‐Ping Chang, Mao‐Tsun Lin, Chung‐Han Ho, Zhih‐Cherng Chen, Sudeshna Fisch, Wei‐Ting Chang
    Journal of the American Heart Association.2021;[Epub]     CrossRef
  • Cardiovascular Safety of Sodium Glucose Cotransporter 2 Inhibitors as Add-on to Metformin Monotherapy in Patients with Type 2 Diabetes Mellitus
    Ja Young Jeon, Kyoung Hwa Ha, Dae Jung Kim
    Diabetes & Metabolism Journal.2021; 45(4): 505.     CrossRef
  • Ipragliflozin, an SGLT2 Inhibitor, Ameliorates High-Fat Diet-Induced Metabolic Changes by Upregulating Energy Expenditure through Activation of the AMPK/ SIRT1 Pathway
    Ji-Yeon Lee, Minyoung Lee, Ji Young Lee, Jaehyun Bae, Eugene Shin, Yong-ho Lee, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha
    Diabetes & Metabolism Journal.2021; 45(6): 921.     CrossRef
  • SGLT2i: beyond the glucose-lowering effect
    Lihua Ni, Cheng Yuan, Guopeng Chen, Changjiang Zhang, Xiaoyan Wu
    Cardiovascular Diabetology.2020;[Epub]     CrossRef
  • Ipragliflozin Additively Ameliorates Non-Alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Controlled with Metformin and Pioglitazone: A 24-Week Randomized Controlled Trial
    Eugene Han, Yong-ho Lee, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha
    Journal of Clinical Medicine.2020; 9(1): 259.     CrossRef
  • Stability Indicating, pH and pKa Dependent HPLC–DAD Method for the Simultaneous Determination of Weakly Ionizable Empagliflozin, Dapagliflozin and Canagliflozin in Pharmaceutical Formulations
    Shahzad Sharif, Rashida Bashir, Ahmad Adnan, Sabiha Mansoor, Izaz Ahmad, Ayoub Rashid Ch, Muhammad Saqlain Tahir
    Chromatographia.2020; 83(12): 1453.     CrossRef
  • Cardiorenal protection with SGLT2: Lessons from the cardiovascular outcome trials
    José Silva‐Cardoso, Omar Sheikh, Mouhamed Nashawi, Son Pham, Kelly M. Gallegos, Laith R. Dinkha, Robert J. Chilton
    Journal of Diabetes.2020; 12(4): 279.     CrossRef
  • Effect of the Sodium-Glucose Cotransporter 2 Inhibitor, Dapagliflozin, on Genitourinary Infection in an Animal Model of Type 2 Diabetes
    Jin Bong Choi, Je Mo Yoo, Ye-Jee Lee, Jae Woong Kim, Seung-Ju Lee, Hee Youn Kim, Dong Sup Lee, Seung-Hyun Ko, Hyun-Sop Choe
    International Neurourology Journal.2020; 24(1): 21.     CrossRef
  • Sodium‐glucose cotransporter 2 inhibitors regulate ketone body metabolism via inter‐organ crosstalk
    Jin Hee Kim, Minyoung Lee, Soo Hyun Kim, So Ra Kim, Byung‐Wan Lee, Eun Seok Kang, Bong‐Soo Cha, Jin Won Cho, Yong‐ho Lee
    Diabetes, Obesity and Metabolism.2019; 21(4): 801.     CrossRef
  • Effects of Sodium-Glucose Cotransporter 2 Inhibitors on Renal Outcomes in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
    Jae Hyun Bae, Eun-Gee Park, Sunhee Kim, Sin Gon Kim, Seokyung Hahn, Nam Hoon Kim
    Scientific Reports.2019;[Epub]     CrossRef
  • SGLT2 inhibition with empagliflozin attenuates myocardial oxidative stress and fibrosis in diabetic mice heart
    Chenguang Li, Jie Zhang, Mei Xue, Xiaoyu Li, Fei Han, Xiangyang Liu, Linxin Xu, Yunhong Lu, Ying Cheng, Ting Li, Xiaochen Yu, Bei Sun, Liming Chen
    Cardiovascular Diabetology.2019;[Epub]     CrossRef
  • An update of SGLT1 and SGLT2 inhibitors in early phase diabetes-type 2 clinical trials
    Ernest Adeghate, Sahar Mohsin, Faisal Adi, Fares Ahmed, Ali Yahya, Huba Kalász, Kornelia Tekes, Ernest A. Adeghate
    Expert Opinion on Investigational Drugs.2019; 28(9): 811.     CrossRef
  • Stability‐indicating chromatographic and chemometric methods for environmentally benign determination of canagliflozin and its major degradation product; A comparative study and greenness assessment
    Aml A. Emam, Nada S. Abdelwahab
    Biomedical Chromatography.2019;[Epub]     CrossRef
  • A Lower Baseline Urinary Glucose Excretion Predicts a Better Response to the Sodium Glucose Cotransporter 2 Inhibitor
    You-Cheol Hwang, Jae Hyeon Kim, Byung-Wan Lee, Woo Je Lee
    Diabetes & Metabolism Journal.2019; 43(6): 898.     CrossRef
  • Predictors of the Therapeutic Efficacy and Consideration of the Best Combination Therapy of Sodium-Glucose Co-transporter 2 Inhibitors
    Ji-Yeon Lee, Yongin Cho, Minyoung Lee, You Jin Kim, Yong-ho Lee, Byung-Wan Lee, Bong-Soo Cha, Eun Seok Kang
    Diabetes & Metabolism Journal.2019; 43(2): 158.     CrossRef
  • Comparative Efficacy and Safety Among Sodium-glucose Cotransporter-2 Inhibitors in Type 2 Diabetes – Results from a Retrospective Single-centre Study
    Manash P Baruah, Sanjay Kalra
    European Endocrinology.2019; 15(2): 113.     CrossRef
  • Canagliflozin stability study and ecofriendly chromatographic determination of its degradation product: A comparative study
    Aml A. Emam
    Journal of Separation Science.2018; 41(4): 822.     CrossRef
  • Efficacy and tolerability of novel triple combination therapy in drug-naïve patients with type 2 diabetes from the TRIPLE-AXEL trial: protocol for an open-label randomised controlled trial
    Nam Hoon Kim, Soo Lim, Soo Heon Kwak, Min Kyong Moon, Jun Sung Moon, Yong-ho Lee, Ho Chan Cho, Juneyoung Lee, Sin Gon Kim
    BMJ Open.2018; 8(9): e022448.     CrossRef
  • Short-term outcomes of patients with Type 2 diabetes mellitus treated with canagliflozin compared with sitagliptin in a real-world setting
    YL Shao, KH Yee, SK, Koh, YF Wong, LY Yeoh, S Low, CF Sum
    Singapore Medical Journal.2018; 59(5): 251.     CrossRef
  • Clinical implications of current cardiovascular outcome trials with sodium glucose cotransporter-2 (SGLT2) inhibitors
    Soo Lim, Robert H. Eckel, Kwang Kon Koh
    Atherosclerosis.2018; 272: 33.     CrossRef
  • Effect of Empagliflozin, a Selective Sodium-Glucose Cotransporter 2 Inhibitor, on Kidney and Peripheral Nerves in Streptozotocin-Induced Diabetic Rats
    Kyung Ae Lee, Heung Yong Jin, Na Young Lee, Yu Ji Kim, Tae Sun Park
    Diabetes & Metabolism Journal.2018; 42(4): 338.     CrossRef
  • The effect of Ramadan fasting and continuing sodium-glucose co-transporter-2 (SGLT2) inhibitor use on ketonemia, blood pressure and renal function in Muslim patients with type 2 diabetes
    Yanli Shao, Gwyneth Joy Lim, Chin Lian Chua, Yip Fong Wong, Ester Chai Kheng Yeoh, Serena Kiat Mun Low, Chee Fang Sum
    Diabetes Research and Clinical Practice.2018; 142: 85.     CrossRef
  • Effect of Dapagliflozin on Alanine Aminotransferase Improvement in Type 2 Diabetes Mellitus with Non-alcoholic Fatty Liver Disease
    Dug-Hyun Choi, Chan-Hee Jung, Ji-Oh Mok, Chul-Hee Kim, Sung-Koo Kang, Bo-Yeon Kim
    Endocrinology and Metabolism.2018; 33(3): 387.     CrossRef
  • Comparison between sodium–glucose cotransporter 2 inhibitors and pioglitazone as additions to insulin therapy in type 2 diabetes patients: A systematic review with an indirect comparison meta‐analysis
    Yun Kyung Cho, Ye‐Jee Kim, Yu Mi Kang, Seung Eun Lee, Joong‐Yeol Park, Woo Je Lee, Chang Hee Jung
    Journal of Diabetes Investigation.2018; 9(4): 882.     CrossRef
  • Characteristics of Dapagliflozin Responders: A Longitudinal, Prospective, Nationwide Dapagliflozin Surveillance Study in Korea
    Eugene Han, Ari Kim, Sung Jae Lee, Je-Yon Kim, Jae Hyeon Kim, Woo Je Lee, Byung-Wan Lee
    Diabetes Therapy.2018; 9(4): 1689.     CrossRef
  • Combining SGLT2 Inhibition With a Thiazolidinedione Additively Attenuate the Very Early Phase of Diabetic Nephropathy Progression in Type 2 Diabetes Mellitus
    Eugene Han, Eugene Shin, Gyuri Kim, Ji-Yeon Lee, Yong-ho Lee, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha
    Frontiers in Endocrinology.2018;[Epub]     CrossRef
  • Clinical parameters affecting dapagliflozin response in patients with type 2 diabetes
    J.-Y. Lee, G. Kim, S.R. Kim, Y.-H. Lee, B.-W. Lee, B.-S. Cha, E.S. Kang
    Diabetes & Metabolism.2017; 43(2): 191.     CrossRef
  • Glucagon and glucagon-like peptide-1 as novel anti-inflammatory and immunomodulatory compounds
    Daniella B.R. Insuela, Vinicius F. Carvalho
    European Journal of Pharmacology.2017; 812: 64.     CrossRef
  • Efficacy and safety of tofogliflozin in Japanese patients with type 2 diabetes mellitus with inadequate glycaemic control on insulin therapy (J‐STEP/INS): Results of a 16‐week randomized, double‐blind, placebo‐controlled multicentre trial
    Yasuo Terauchi, Masahiro Tamura, Masayuki Senda, Ryoji Gunji, Kohei Kaku
    Diabetes, Obesity and Metabolism.2017; 19(10): 1397.     CrossRef
  • A comparison of effects of DPP-4 inhibitor and SGLT2 inhibitor on lipid profile in patients with type 2 diabetes
    Seon-Ah Cha, Yong-Moon Park, Jae-Seung Yun, Tae-Seok Lim, Ki-Ho Song, Ki-Dong Yoo, Yu-Bae Ahn, Seung-Hyun Ko
    Lipids in Health and Disease.2017;[Epub]     CrossRef
  • Morning Spot Urine Glucose-to-Creatinine Ratios Predict Overnight Urinary Glucose Excretion in Patients With Type 2 Diabetes
    So Ra Kim, Yong-ho Lee, Sang-Guk Lee, Sun Hee Lee, Eun Seok Kang, Bong-Soo Cha, Hyun Chul Lee, Jeong-Ho Kim, Byung-Wan Lee
    Annals of Laboratory Medicine.2017; 37(1): 9.     CrossRef
  • The Relationship between Increases in Morning Spot Urinary Glucose Excretion and Decreases in HbA1C in Patients with Type 2 Diabetes After Taking an SGLT2 Inhibitor: A Retrospective, Longitudinal Study
    So Ra Kim, Yong-ho Lee, Eun Seok Kang, Bong-Soo Cha, Byung-Wan Lee
    Diabetes Therapy.2017; 8(3): 601.     CrossRef
  • Clinical and Genetic Features of Patients With Type 2 Diabetes and Renal Glycosuria
    Siqian Gong, Jiandong Guo, Xueyao Han, Meng Li, Lingli Zhou, Xiaoling Cai, Yu Zhu, Yingying Luo, Simin Zhang, Xianghai Zhou, Yumin Ma, Linong Ji
    The Journal of Clinical Endocrinology & Metabolism.2017; 102(5): 1548.     CrossRef
  • Effect of Sodium-Glucose Co-Transporter 2 Inhibitor, Dapagliflozin, on Renal Renin-Angiotensin System in an Animal Model of Type 2 Diabetes
    Seok Joon Shin, Sungjin Chung, Soo Jung Kim, Eun-Mi Lee, Young-Hye Yoo, Ji-Won Kim, Yu-Bae Ahn, Eun-Sook Kim, Sung-Dae Moon, Myung-Jun Kim, Seung-Hyun Ko, Kwang-Hyun Baek
    PLOS ONE.2016; 11(11): e0165703.     CrossRef
  • Sodium–glucose cotransporter 2 inhibitors: an evidence-based practice approach to their use in the natural history of type 2 diabetes
    Stanley S. Schwartz, Intekhab Ahmed
    Current Medical Research and Opinion.2016; 32(5): 907.     CrossRef
  • Insulin resistance, role of metformin and other non-insulin therapies in pediatric type 1 diabetes
    Fida Bacha, Sara Klinepeter Bartz
    Pediatric Diabetes.2016; 17(8): 545.     CrossRef
  • Renal threshold for glucose reabsorption predicts diabetes improvement by sodium‐glucose cotransporter 2 inhibitor therapy
    Aya Osaki, Shuichi Okada, Tsugumichi Saito, Eijiro Yamada, Kumeo Ono, Yawara Niijima, Hiroto Hoshi, Masanobu Yamada
    Journal of Diabetes Investigation.2016; 7(5): 751.     CrossRef
  • Sodium-glucose co-transporter inhibition in the treatment of diabetes: Sweetening the pot
    Carlos A Alvarez, Ian J Neeland, Darren K McGuire
    Diabetes and Vascular Disease Research.2015; 12(2): 74.     CrossRef
  • A simple and sensitive high performance liquid chromatography assay with a fluorescence detector for determination of canagliflozin in human plasma
    Muzaffar Iqbal, Nasr Y. Khalil, Amer M. Alanazi, Khalid A. Al-Rashood
    Analytical Methods.2015; 7(7): 3028.     CrossRef
  • Efficacy and safety of sodium–glucose cotransporter 2 inhibitors in type 2 diabetes: a meta-analysis of randomized controlled trials for 1 to 2 years
    Xiang-Yang Liu, Ning Zhang, Rui Chen, Jia-Guo Zhao, Pei Yu
    Journal of Diabetes and its Complications.2015; 29(8): 1295.     CrossRef
  • Severe hypercalcemia and hypernatremia in a patient treated with canagliflozin
    Arshpreet Kaur, Stephen J Winters
    Endocrinology, Diabetes & Metabolism Case Reports.2015;[Epub]     CrossRef
  • Pharmacological treatment and therapeutic perspectives of metabolic syndrome
    Soo Lim, Robert H. Eckel
    Reviews in Endocrine and Metabolic Disorders.2014; 15(4): 329.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal
Close layer
TOP