Obesity and diabetes has become a major epidemic across the globe. Controlling obesity has been a challenge since this would require either increased physical activity or reduced caloric intake; both are difficult to enforce. There has been renewed interest in exploiting pathways such as uncoupling protein 1 (UCP1)-mediated uncoupling in brown adipose tissue (BAT) and white adipose tissue to increase energy expenditure to control weight gain. However, relying on UCP1-based thermogenesis alone may not be sufficient to control obesity in humans. On the other hand, skeletal muscle is the largest organ and a major contributor to basal metabolic rate and increasing energy expenditure in muscle through nonshivering thermogenic mechanisms, which can substantially affect whole body metabolism and weight gain. In this review we will describe the role of Sarcolipin-mediated uncoupling of Sarcoplasmic Reticulum Calcium ATPase (SERCA) as a potential mechanism for increased energy expenditure both during cold and diet-induced thermogenesis.

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• Nutrition as the foundation for successful aging: a focus on dietary protein and omega-3 polyunsaturated fatty acids
  Aubree L Hawley, Jamie I Baum
  Nutrition Reviews.2024; 82(3): 389.     CrossRef
• Seasonal adaptation of Mangalica pigs in terms of muscle morphology and metabolism
  Sangwoo Kim, Chisato Nakayama, Daisuke Kondoh, Tatsuki Okazaki, Erina Yoneda, Kisaki Tomita, Motoki Sasaki, Yuki Muranishi
  Anatomia, Histologia, Embryologia.2024;[Epub]     CrossRef
• In vivo heat production dynamics during a contraction-relaxation cycle in rat single skeletal muscle fibers
  Ayaka Tabuchi, Yoshinori Tanaka, Hiroshi Horikawa, Takuto Tazawa, David C. Poole, Yutaka Kano
  Journal of Thermal Biology.2024; 119: 103760.     CrossRef
• Echinacoside stimulates myogenesis and ATP-dependent thermogenesis in the skeletal muscle via the activation of D1-like dopaminergic receptors
  Kiros Haddish, Jong Won Yun
  Archives of Biochemistry and Biophysics.2024; 752: 109886.     CrossRef
• Ectodysplasin A2 receptor signaling in skeletal muscle pathophysiology
  Sevgi Döndü Özen, Serkan Kir
  Trends in Molecular Medicine.2024; 30(5): 471.     CrossRef
• Chronic melatonin treatment improves obesity by inducing uncoupling of skeletal muscle SERCA-SLN mediated by CaMKII/AMPK/PGC1α pathway and mitochondrial biogenesis in female and male Zücker diabetic fatty rats
  D. Salagre, M. Navarro-Alarcón, M. Villalón-Mir, B. Alcázar-Navarrete, G. Gómez-Moreno, F. Tamimi, A. Agil
  Biomedicine & Pharmacotherapy.2024; 172: 116314.     CrossRef
• Homotaurine exhibits contrasting effects of DRD1-mediated thermogenesis-related regulators in C2C12 myoblasts and 3T3−L1 white adipocytes
  Kiros Haddish, Jong Won Yun
  Biotechnology and Bioprocess Engineering.2024; 29(4): 673.     CrossRef
• Hairless (Hr) Deficiency Mitigates High‐Fat Diet‐Induced Obesity and Insulin Resistance in Mice
  Hongwei Wang, Haoyu Guo, Kuicheng Zhu, Long He, Jian‐jun Yang
  Advanced Biology.2024;[Epub]     CrossRef
• Prediction of resting energy expenditure for adolescents with severe obesity: A multi‐centre analysis
  Amy A. Rydin, Cameron Severn, Laura Pyle, Nazeen Morelli, Ashley H. Shoemaker, Stephanie T. Chung, Jack A. Yanovski, Joan C. Han, Janine A. Higgins, Kristen J. Nadeau, Claudia Fox, Aaron S. Kelly, Melanie G. Cree
  Pediatric Obesity.2024;[Epub]     CrossRef
• Bile acid metabolism and signaling in health and disease: molecular mechanisms and therapeutic targets
  Joshua S. Fleishman, Sunil Kumar
  Signal Transduction and Targeted Therapy.2024;[Epub]     CrossRef
• Unveiling the Potential of Natural Compounds: A Comprehensive Review on Adipose Thermogenesis Modulation
  Jaeeun Shin, Yeonho Lee, Seong Hun Ju, Young Jae Jung, Daehyeon Sim, Sung-Joon Lee
  International Journal of Molecular Sciences.2024; 25(9): 4915.     CrossRef
• 3D Printing of Polysaccharide-Based Hydrogel Scaffolds for Tissue Engineering Applications: A Review
  Arnaud Kamdem Tamo, Lesly Dasilva Wandji Djouonkep, Naomie Beolle Songwe Selabi
  International Journal of Biological Macromolecules.2024; 270: 132123.     CrossRef
• Remodeling of skeletal muscle myosin metabolic states in hibernating mammals
  Christopher TA Lewis, Elise G Melhedegaard, Marija M Ognjanovic, Mathilde S Olsen, Jenni Laitila, Robert AE Seaborne, Magnus Gronset, Changxin Zhang, Hiroyuki Iwamoto, Anthony L Hessel, Michel N Kuehn, Carla Merino, Nuria Amigo, Ole Frobert, Sylvain Girou
  eLife.2024;[Epub]     CrossRef
• Relative sarcolipin (SLN) and sarcoplasmic reticulum Ca2+ ATPase (SERCA1) transcripts levels in closely related endothermic and ectothermic scombrid fishes: Implications for molecular basis of futile calcium cycle non-shivering thermogenesis (NST)
  Sean Robinson, Nicholas C. Wegner, Chugey A. Sepulveda, Jens P.C. Franck
  Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology.2024; 295: 111667.     CrossRef
• WITHDRAWN: COVID-19: Post infection implications in different age groups, mechanism, diagnosis, effective prevention, treatment, and recommendations
  Muhammad Akmal Raheem, Muhammad Ajwad Rahim, Ijaz Gul, Md. Reyad-ul-Ferdous, Can Yang Zhang, Dongmei Yu, Vijay Pandey, Ke Du, Runming Wang, Sanyang Han, Yuxing Han, Peiwu Qin
  Life Sciences.2024; : 122861.     CrossRef
• Effects of 3-(4-Hydroxy-3-methoxyphenyl)propionic Acid on Enhancing Grip Strength and Inhibiting Protein Catabolism Induced by Exhaustive Exercise
  Yishan Tong, Jiapeng Huang, Shuo Wang, Riyo Awa, Takashi Tagawa, Ziwei Zhang, Tiehan Cao, Haruki Kobori, Katsuhiko Suzuki
  International Journal of Molecular Sciences.2024; 25(12): 6627.     CrossRef
• FOXO-regulated DEAF1 controls muscle regeneration through autophagy
  Kah Yong Goh, Wen Xing Lee, Sze Mun Choy, Gopal Krishnan Priyadarshini, Kenon Chua, Qian Hui Tan, Shin Yi Low, Hui San Chin, Chee Seng Wong, Shu-Yi Huang, Nai Yang Fu, Jun Nishiyama, Nathan Harmston, Hong-Wen Tang
  Autophagy.2024; : 1.     CrossRef
• ROS-Induced Autophagy of Skeletal Muscle Confers Resistance of Rice Flower Carp (Cyprinus carpio) to Short-Term Fasting
  Jia Cheng, Junhan Luo, Ziyang Xu, Zhouying Liu, Lingsheng Bao, Liangyi Xue
  Genes.2024; 15(7): 840.     CrossRef
• Cold environments and human metabolism: A traditional chinese medicine perspective
  Tengyu Zhao, Yifu Ma, Jian Zhang, Xiaojie Zhou, Yanyan Zhou, Jingdong Yan
  Frigid Zone Medicine.2024; 4(2): 78.     CrossRef
• Skeletal muscle: molecular structure, myogenesis, biological functions, and diseases
  Lan‐Ting Feng, Zhi‐Nan Chen, Huijie Bian
  MedComm.2024;[Epub]     CrossRef
• The novel chimeric multi-agonist peptide (GEP44) reduces energy intake and body weight in male and female diet-induced obese mice in a glucagon-like peptide-1 receptor-dependent manner
  James E. Blevins, Mackenzie K. Honeycutt, Jared D. Slattery, Matvey Goldberg, June R. Rambousek, Edison Tsui, Andrew D. Dodson, Kyra A. Shelton, Therese S. Salemeh, Clinton T. Elfers, Kylie S. Chichura, Emily F. Ashlaw, Sakeneh Zraika, Robert P. Doyle, Ch
  Frontiers in Endocrinology.2024;[Epub]     CrossRef
• Sympathetic innervation of interscapular brown adipose tissue is not a predominant mediator of oxytocin-elicited reductions of body weight and adiposity in male diet-induced obese mice
  Melise M. Edwards, Ha K. Nguyen, Andrew D. Dodson, Adam J. Herbertson, Tami Wolden-Hanson, Tomasz A. Wietecha, Mackenzie K. Honeycutt, Jared D. Slattery, Kevin D. O’Brien, James L. Graham, Peter J. Havel, Thomas O. Mundinger, Carl L. Sikkema, Elaine R. Pe
  Frontiers in Endocrinology.2024;[Epub]     CrossRef
• Timing of acute cold exposure determines UCP1 and FGF21 expression - Possible interactions between the thermal environment, thermoregulatory responses, and peripheral clocks
  Phong KT. Chau, Elin Ryan, Knut Tomas Dalen, Fred Haugen
  Journal of Thermal Biology.2024; 124: 103938.     CrossRef
• Critical variables regulating age-related anabolic responses to protein nutrition in skeletal muscle
  Colleen S. Deane, Jake Cox, Philip J. Atherton
  Frontiers in Nutrition.2024;[Epub]     CrossRef
• Can non-invasive motor unit analysis reveal distinct neural strategies of force production in young with uncomplicated type 1 diabetes?
  Giacomo Valli, Rui Wu, Dean Minnock, Giuseppe Sirago, Giosuè Annibalini, Andrea Casolo, Alessandro Del Vecchio, Luana Toniolo, Elena Barbieri, Giuseppe De Vito
  European Journal of Applied Physiology.2024;[Epub]     CrossRef
• Spatial Transcriptomics Analysis: Maternal Obesity Impairs Myogenic Cell Migration and Differentiation during Embryonic Limb Development
  Yao Gao, Md Nazmul Hossain, Liang Zhao, Jeanene Marie Deavila, Nathan C. Law, Mei-Jun Zhu, Gordon K. Murdoch, Min Du
  International Journal of Molecular Sciences.2024; 25(17): 9488.     CrossRef
• How Multifunctioning Joints Produce Highly Agile Limbs in Animals with Lessons for Robotics
  Stuart C. Burgess
  Biomimetics.2024; 9(9): 529.     CrossRef
• Incretin-Based Weight Loss Pharmacotherapy: Can Resistance Exercise Optimize Changes in Body Composition?
  João Carlos Locatelli, Juliene Gonçalves Costa, Andrew Haynes, Louise H. Naylor, P. Gerry Fegan, Bu B. Yeap, Daniel J. Green
  Diabetes Care.2024; 47(10): 1718.     CrossRef
• The effect of high fat diet and endurance training on newly discovery of nonshivering-thermogenic factors under thermoneutrality in mice
  S. Daneshyar, A. Ghasemnian, Z. Mirakhori, S.J. Daneshyar
  Science & Sports.2023; 38(3): 293.     CrossRef
• Redox‐metabolic reprogramming of skin in mice lacking functional Nrf2 under basal conditions and cold acclimation
  Tamara Zakic, Sara Stojanovic, Aleksandra Jankovic, Aleksandra Korac, Vanja Pekovic‐Vaughan, Bato Korac
  BioFactors.2023; 49(3): 600.     CrossRef
• Rats lackingUcp1present a novel translational tool for the investigation of thermogenic adaptation during cold challenge
  Jaycob D. Warfel, Carrie M. Elks, David S. Bayless, Bolormaa Vandanmagsar, Allison C. Stone, Samuel E. Velasquez, Paola Olivares‐Nazar, Robert C. Noland, Sujoy Ghosh, Jingying Zhang, Randall L. Mynatt
  Acta Physiologica.2023;[Epub]     CrossRef
• SENP2 knockdown in human adipocytes reduces glucose metabolism and lipid accumulation, while increases lipid oxidation
  Solveig A. Krapf, Jenny Lund, Hege G. Bakke, Tuula A. Nyman, Stefano Bartesaghi, Xiao-Rong Peng, Arild C. Rustan, G. Hege Thoresen, Eili T. Kase
  Metabolism Open.2023; 18: 100234.     CrossRef
• Physiological and molecular mechanisms of cold-induced improvements in glucose homeostasis in humans beyond brown adipose tissue
  Sten van Beek, Dzhansel Hashim, Tore Bengtsson, Joris Hoeks
  International Journal of Obesity.2023; 47(5): 338.     CrossRef
• Distinct Transcriptional Responses of Skeletal Muscle to Short-Term Cold Exposure in Tibetan Pigs and Bama Pigs
  Chunhuai Yang, Chunwei Cao, Jiali Liu, Ying Zhao, Jianfei Pan, Cong Tao, Yanfang Wang
  International Journal of Molecular Sciences.2023; 24(8): 7431.     CrossRef
• Distinct and shared endothermic strategies in the heat producing tissues of tuna and other teleosts
  Baosheng Wu, Xueli Gao, Mingling Hu, Jing Hu, Tianming Lan, Tingfeng Xue, Wenjie Xu, Chenglong Zhu, Yuan Yuan, Jiangmin Zheng, Tao Qin, Peidong Xin, Ye Li, Li Gong, Chenguang Feng, Shunping He, Huan Liu, Haimeng Li, Qing Wang, Zhenhua Ma, Qiang Qiu, Kun W
  Science China Life Sciences.2023; 66(11): 2629.     CrossRef
• Macrophage Involvement in Aging-Associated Skeletal Muscle Regeneration
  Chang-Yi Cui, Luigi Ferrucci, Myriam Gorospe
  Cells.2023; 12(9): 1214.     CrossRef
• Anti-nucleolin aptamer, iSN04, inhibits the inflammatory responses in C2C12 myoblasts by modulating the β-catenin/NF-κB signaling pathway
  Machi Yamamoto, Mana Miyoshi, Kamino Morioka, Takakazu Mitani, Tomohide Takaya
  Biochemical and Biophysical Research Communications.2023; 664: 1.     CrossRef
• Building Cetacean Locomotor Muscles throughout Ontogeny to Support High-Performance Swimming into Adulthood
  S R Noren
  Integrative And Comparative Biology.2023; 63(3): 785.     CrossRef
• Filbertone, (2E)-5-methyl-2-hepten-4-one, regulates thermogenesis and lipid metabolism in skeletal muscle of a high-fat diet fed mice
  Hyemee Kim, Byungyong Ahn
  Applied Biological Chemistry.2023;[Epub]     CrossRef
• Silencing of dopamine receptor D5 inhibits the browning of 3T3-L1 adipocytes and ATP-consuming futile cycles in C2C12 muscle cells
  Kiros Haddish, Jong Won Yun
  Archives of Physiology and Biochemistry.2023; : 1.     CrossRef
• Dynamic of irisin secretion change after moderate-intensity chronic physical exercise on obese female
  Desiana Merawati, Sugiharto, Hendra Susanto, Ahmad Taufiq, Adi Pranoto, Dessy Amelia, Purwo Sri Rejeki
  Journal of Basic and Clinical Physiology and Pharmacology.2023; 34(4): 539.     CrossRef
• Polyamines and Physical Activity in Musculoskeletal Diseases: A Potential Therapeutic Challenge
  Letizia Galasso, Annalisa Cappella, Antonino Mulè, Lucia Castelli, Andrea Ciorciari, Alessandra Stacchiotti, Angela Montaruli
  International Journal of Molecular Sciences.2023; 24(12): 9798.     CrossRef
• Phosphate toxicity and SERCA2a dysfunction in sudden cardiac arrest
  Ronald B. Brown
  The FASEB Journal.2023;[Epub]     CrossRef
• Hepatic protein kinase Cbeta deficiency mitigates late-onset obesity
  Yaoling Shu, Nikhil Gumma, Faizule Hassan, Daniel A. Branch, Lisa A. Baer, Michael C. Ostrowski, Kristin I. Stanford, Kedryn K. Baskin, Kamal D. Mehta
  Journal of Biological Chemistry.2023; 299(8): 104917.     CrossRef
• Functional expression of the thermally activated transient receptor potential channels TRPA1 and TRPM8 in human myotubes
  Christine Skagen, Nils Gunnar Løvsletten, Lucia Asoawe, Zeineb Al-Karbawi, Arild C. Rustan, G. Hege Thoresen, Fred Haugen
  Journal of Thermal Biology.2023; 116: 103623.     CrossRef
• Natural products as novel anti-obesity agents: insights into mechanisms of action and potential for therapeutic management
  Ummul Fathima Shaik Mohamed Sayed, Said Moshawih, Hui Poh Goh, Nurolaini Kifli, Gaurav Gupta, Sachin Kumar Singh, Dinesh Kumar Chellappan, Kamal Dua, Andi Hermansyah, Hooi Leng Ser, Long Chiau Ming, Bey Hing Goh
  Frontiers in Pharmacology.2023;[Epub]     CrossRef
• Recent advancements in pharmacological strategies to modulate energy balance for combating obesity
  Benudhara Pati, Satyabrata Sendh, Bijayashree Sahu, Sunil Pani, Nivedita Jena, Naresh Chandra Bal
  RSC Medicinal Chemistry.2023; 14(8): 1429.     CrossRef
• CCE and EODF as two distinct non-shivering thermogenesis models inducing weight loss
  Tianyi Xu, Juan Wang, Hongwei Shi, Xiaofang Wei, Huiling Zhang, Yunyan Ji, Shiting Lu, Yi Yan, Xiuju Yu, Xiaomao Luo, Haidong Wang
  Pflügers Archiv - European Journal of Physiology.2023; 475(8): 961.     CrossRef
• Birth and the Pathway to Adulthood: Integration across Development, Environment, and Evolution
  Christopher J Mayerl, Terry R Dial, Mark C Mainwaring, Ashley M Heers, Rebecca Z German
  Integrative And Comparative Biology.2023; 63(3): 548.     CrossRef
• Adipose Tissue and Metabolic Health
  Sung-Min An, Seung-Hee Cho, John C. Yoon
  Diabetes & Metabolism Journal.2023; 47(5): 595.     CrossRef
• The RANK-RANK-L-OPG pathway: trait d’union between bone and muscle
  Giovanni Iolascon, Sara Liguori, Marco Paoletta, Federica Tomaino, Antimo Moretti
  International Journal of Bone Fragility.2023; 3(2): 56.     CrossRef
• Warm Cells, Hot Mitochondria: Achievements and Problems of Ultralocal Thermometry
  Alexey G. Kruglov, Alexey M. Romshin, Anna B. Nikiforova, Arina Plotnikova, Igor I. Vlasov
  International Journal of Molecular Sciences.2023; 24(23): 16955.     CrossRef
• Plant extracts in prevention of obesity
  Han-Ning Wang, Jin-Zhu Xiang, Zhi Qi, Min Du
  Critical Reviews in Food Science and Nutrition.2022; 62(8): 2221.     CrossRef
• Transcription factor EB enhances autophagy and ameliorates palmitate‐induced insulin resistance at least partly via upregulating AMPK activity in skeletal muscle cells
  Ping Wang, Chun Guang Li, Xian Zhou, Shuzhe Ding
  Clinical and Experimental Pharmacology and Physiology.2022; 49(2): 302.     CrossRef
• ATP-consuming futile cycles as energy dissipating mechanisms to counteract obesity
  Alexandra J. Brownstein, Michaela Veliova, Rebeca Acin-Perez, Marc Liesa, Orian S. Shirihai
  Reviews in Endocrine and Metabolic Disorders.2022; 23(1): 121.     CrossRef
• Skeletal muscle plasticity and thermogenesis: Insights from sea otters
  Traver Wright, Melinda Sheffield-Moore
  Temperature.2022; 9(2): 119.     CrossRef
• Augmented CCL5/CCR5 signaling in brown adipose tissue inhibits adaptive thermogenesis and worsens insulin resistance in obesity
  Pei-Chi Chan, Li-Man Hung, Jiung-Pang Huang, Yuan-Ji Day, Chao-Lan Yu, Feng-Chih Kuo, Chieh-Hua Lu, Yu-Feng Tian, Po-Shiuan Hsieh
  Clinical Science.2022; 136(1): 121.     CrossRef
• Altered muscle mitochondrial, inflammatory and trophic markers, and reduced exercise training adaptations in type 1 diabetes
  Dean Minnock, Giosuè Annibalini, Giacomo Valli, Roberta Saltarelli, Mauricio Krause, Elena Barbieri, Giuseppe De Vito
  The Journal of Physiology.2022; 600(6): 1405.     CrossRef
• Maternal exercise intergenerationally drives muscle-based thermogenesis via activation of apelin-AMPK signaling
  Jun Seok Son, Song Ah Chae, Liang Zhao, Hongyang Wang, Jeanene M. de Avila, Mei-Jun Zhu, Zhihua Jiang, Min Du
  eBioMedicine.2022; 76: 103842.     CrossRef
• Ca 2+ leak through ryanodine receptor 1 regulates thermogenesis in resting skeletal muscle
  Aldo Meizoso-Huesca, Luke Pearce, Christopher J. Barclay, Bradley S. Launikonis
  Proceedings of the National Academy of Sciences.2022;[Epub]     CrossRef
• Deep transcranial magnetic stimulation in combination with skin thermography in obesity: a window on sympathetic nervous system
  Anna Ferrulli, Sara Gandini, Giulio Cammarata, Veronica Redaelli, Stefano Massarini, Concetta Macrì, Ileana Terruzzi, Daniele Cannavaro, Fabio Luzi, Livio Luzi
  Acta Diabetologica.2022; 59(5): 729.     CrossRef
• Knockdown of sarcolipin (SLN) impairs substrate utilization in human skeletal muscle cells
  Abel M. Mengeste, Parmeshwar Katare, Andrea Dalmao Fernandez, Jenny Lund, Hege G. Bakke, David Baker, Stefano Bartesaghi, Xiao-Rong Peng, Arild C. Rustan, G. Hege Thoresen, Eili Tranheim Kase
  Molecular Biology Reports.2022; 49(7): 6005.     CrossRef
• The Role of Thyroid Hormones on Skeletal Muscle Thermogenesis
  Nadia Sawicka-Gutaj, Abikasinee Erampamoorthy, Ariadna Zybek-Kocik, Angelos Kyriacou, Małgorzata Zgorzalewicz-Stachowiak, Agata Czarnywojtek, Marek Ruchała
  Metabolites.2022; 12(4): 336.     CrossRef
• SS‐31 does not prevent or reduce muscle atrophy 7 days after a 65 kdyne contusion spinal cord injury in young male mice
  Zachary A. Graham, Jennifer J. DeBerry, Christopher P. Cardozo, Marcas M. Bamman
  Physiological Reports.2022;[Epub]     CrossRef
• Exercise, Mitohormesis, and Mitochondrial ORF of the 12S rRNA Type-C (MOTS-c)
  Tae Kwan Yoon, Chan Hee Lee, Obin Kwon, Min-Seon Kim
  Diabetes & Metabolism Journal.2022; 46(3): 402.     CrossRef
• Insight Into the Metabolic Adaptations of Electrically Pulse-Stimulated Human Myotubes Using Global Analysis of the Transcriptome and Proteome
  Abel M. Mengeste, Nataša Nikolić, Andrea Dalmao Fernandez, Yuan Z. Feng, Tuula A. Nyman, Sander Kersten, Fred Haugen, Eili Tranheim Kase, Vigdis Aas, Arild C. Rustan, G. Hege Thoresen
  Frontiers in Physiology.2022;[Epub]     CrossRef
• The Role of Thermogenic Fat Tissue in Energy Consumption
  Masato Horino, Kenji Ikeda, Tetsuya Yamada
  Current Issues in Molecular Biology.2022; 44(7): 3166.     CrossRef
• Investigation of obesogenic effects of hexachlorobenzene, DDT and DDE in male rats
  Zeyad Ayad Fadhil Al-Obaidi, Cihan Süleyman Erdogan, Engin Sümer, Hüseyin Bugra Özgün, Burcu Gemici, Süleyman Sandal, Bayram Yilmaz
  General and Comparative Endocrinology.2022; 327: 114098.     CrossRef
• Avian adjustments to cold and non‐shivering thermogenesis: whats, wheres and hows
  Punyadhara Pani, Naresh C. Bal
  Biological Reviews.2022; 97(6): 2106.     CrossRef
• Thirty Obesity Myths, Misunderstandings, and/or Oversimplifications: An Obesity Medicine Association (OMA) Clinical Practice Statement (CPS) 2022
  Harold Edward Bays, Angela Golden, Justin Tondt
  Obesity Pillars.2022; 3: 100034.     CrossRef
• Myogenetic Oligodeoxynucleotide Restores Differentiation and Reverses Inflammation of Myoblasts Aggravated by Cancer-Conditioned Medium
  Yuma Nihashi, Machi Yamamoto, Takeshi Shimosato, Tomohide Takaya
  Muscles.2022; 1(2): 111.     CrossRef
• Altered skeletal muscle sarco-endoplasmic reticulum Ca2+-ATPase calcium transport efficiency after a thermogenic stimulus
  Lydia A. Heemstra, Lauren G. Koch, Steven L. Britton, Colleen M. Novak
  American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.2022; 323(5): R628.     CrossRef
• Animal Welfare Compromises Associated with Causes of Death in Neonatal Piglets
  Kirsty L. Chidgey, Nutnapong Udomteerasuwat, Patrick C. H. Morel, Fernanda Castillo-Alcala
  Animals.2022; 12(21): 2933.     CrossRef
• Brown to White Fat Transition Overlap With Skeletal Muscle During Development of Larger Mammals: Is it a Coincidence?
  Sunil Pani, Suchanda Dey, Benudhara Pati, Unmod Senapati, Naresh C Bal
  Journal of the Endocrine Society.2022;[Epub]     CrossRef
• Anti‐adiposity and lipid‐lowering effects of schisandrol A in diet‐induced obese mice
  Sang Ryong Kim, Hyo Jin Park, Un Ju Jung
  Journal of Food Biochemistry.2022;[Epub]     CrossRef
• Changes in spike protein antibody titer over 90 days after the second dose of SARS-CoV-2 vaccine in Japanese dialysis patients
  Haruki Wakai, Natsumi Abe, Touno Tokuda, Rika Yamanaka, Satoshi Ebihara, Kensuke Izumaru, Daisuke Ishii, Toru Hyodo, Kazunari Yoshida
  BMC Infectious Diseases.2022;[Epub]     CrossRef
• Organotypic cultures as aging associated disease models
  Martina M. Sanchez, Isabella A. Bagdasarian, William Darch, Joshua T. Morgan
  Aging.2022; 14(22): 9338.     CrossRef
• Divergent remodeling of the skeletal muscle metabolome over 24 h between young, healthy men and older, metabolically compromised men
  Jan-Frieder Harmsen, Michel van Weeghel, Rex Parsons, Georges E. Janssens, Jakob Wefers, Dirk van Moorsel, Jan Hansen, Joris Hoeks, Matthijs K.C. Hesselink, Riekelt H. Houtkooper, Patrick Schrauwen
  Cell Reports.2022; 41(11): 111786.     CrossRef
• Structural functionality of skeletal muscle mitochondria and its correlation with metabolic diseases
  Gourabamani Swalsingh, Punyadhara Pani, Naresh C. Bal
  Clinical Science.2022; 136(24): 1851.     CrossRef
• Trans-anethole Induces Thermogenesis via Activating SERCA/SLN Axis in C2C12 Muscle Cells
  Sulagna Mukherjee, Minji Choi, Jong Won Yun
  Biotechnology and Bioprocess Engineering.2022; 27(6): 938.     CrossRef
• Umbilical Cord-Mesenchymal Stem Cell-Conditioned Medium Improves Insulin Resistance in C2C12 Cell
  Kyung-Soo Kim, Yeon Kyung Choi, Mi Jin Kim, Jung Wook Hwang, Kyunghoon Min, Sang Youn Jung, Soo-Kyung Kim, Yong-Soo Choi, Yong-Wook Cho
  Diabetes & Metabolism Journal.2021; 45(2): 260.     CrossRef
• Nutmeg extract potentially alters characteristics of white adipose tissue in rats
  Ronny Lesmana, Melisa Siannoto, Gaga I. Nugraha, Hanna Goenawan, Astrid K. Feinisa, Yuni S. Pratiwi, Fifi Veronica, Vita M. Tarawan, Susianti Susianti, Unang Supratman
  Veterinary Medicine and Science.2021; 7(2): 512.     CrossRef
• Contribution of thermogenic mechanisms by male and female mice lacking pituitary adenylate cyclase-activating polypeptide in response to cold acclimation
  Ekaterina Filatov, Landon I. Short, Maeghan A. M. Forster, Simon S. Harris, Erik N. Schien, Malcolm C. Hughes, Daemon L. Cline, Colin J. Appleby, Sarah L. Gray
  American Journal of Physiology-Endocrinology and Metabolism.2021; 320(3): E475.     CrossRef
• Skeletal muscle non-shivering thermogenesis as an attractive strategy to combat obesity
  Hanbing Li, Can Wang, Linghuan Li, Lingqiao Li
  Life Sciences.2021; 269: 119024.     CrossRef
• Restriction of an intron sizeen routeto endothermy
  Jana Královičová, Ivana Borovská, Reuben Pengelly, Eunice Lee, Pavel Abaffy, Radek Šindelka, Frank Grutzner, Igor Vořechovský
  Nucleic Acids Research.2021; 49(5): 2460.     CrossRef
• Skeletal muscle specific mitochondrial dysfunction and altered energy metabolism in a murine model (oim/oim) of severe osteogenesis imperfecta
  Victoria L. Gremminger, Emily N. Harrelson, Tara K. Crawford, Adrienne Ohler, Laura C. Schulz, R. Scott Rector, Charlotte L. Phillips
  Molecular Genetics and Metabolism.2021; 132(4): 244.     CrossRef
• Body Protein Sparing in Hibernators: A Source for Biomedical Innovation
  Fabrice Bertile, Caroline Habold, Yvon Le Maho, Sylvain Giroud
  Frontiers in Physiology.2021;[Epub]     CrossRef
• The Genomes of Two Billfishes Provide Insights into the Evolution of Endothermy in Teleosts
  Baosheng Wu, Chenguang Feng, Chenglong Zhu, Wenjie Xu, Yuan Yuan, Mingliang Hu, Ke Yuan, Yongxin Li, Yandong Ren, Yang Zhou, Haifeng Jiang, Qiang Qiu, Wen Wang, Shunping He, Kun Wang, Guang Yang
  Molecular Biology and Evolution.2021; 38(6): 2413.     CrossRef
• Is Upregulation of Sarcolipin Beneficial or Detrimental to Muscle Function?
  Naresh C. Bal, Subash C. Gupta, Meghna Pant, Danesh H. Sopariwala, Geoffrey Gonzalez-Escobedo, Joanne Turner, John S. Gunn, Christopher R. Pierson, Scott Q. Harper, Jill A. Rafael-Fortney, Muthu Periasamy
  Frontiers in Physiology.2021;[Epub]     CrossRef
• Real‐Time Assessment of Mitochondrial Toxicity in HepG2 Cells Using the Seahorse Extracellular Flux Analyzer
  Jether Amos Espinosa, Grace Pohan, Michelle R. Arkin, Sarine Markossian
  Current Protocols.2021;[Epub]     CrossRef
• Effects of Ecklonia stolonifera extract on the obesity and skeletal muscle regeneration in high-fat diet-fed mice
  Heegu Jin, Hyun-Ji Oh, Junghee Kim, Kang-Pyo Lee, Xionggao Han, Ok-Hwan Lee, Boo-Yong Lee
  Journal of Functional Foods.2021; 82: 104511.     CrossRef
• The Effect of Dietary Intake and Nutritional Status on Anthropometric Development and Systemic Inflammation: An Observational Study
  Roxana Maria Martin-Hadmaș, Ștefan Adrian Martin, Adela Romonți, Cristina Oana Mărginean
  International Journal of Environmental Research and Public Health.2021; 18(11): 5635.     CrossRef
• Thermographic imaging of mouse across circadian time reveals body surface temperature elevation associated with non-locomotor body movements
  Hiroyuki Shimatani, Yuichi Inoue, Yota Maekawa, Takahito Miyake, Yoshiaki Yamaguchi, Masao Doi, Nicolas Cermakian
  PLOS ONE.2021; 16(5): e0252447.     CrossRef
• Human umbilical cord mesenchymal stem cells in type 2 diabetes mellitus: the emerging therapeutic approach
  Andreia Gomes, Pedro Coelho, Raquel Soares, Raquel Costa
  Cell and Tissue Research.2021; 385(3): 497.     CrossRef
• Central vs. Peripheral Action of Thyroid Hormone in Adaptive Thermogenesis: A Burning Topic
  Yanis Zekri, Frédéric Flamant, Karine Gauthier
  Cells.2021; 10(6): 1327.     CrossRef
• Myogenetic Oligodeoxynucleotide (myoDN) Recovers the Differentiation of Skeletal Muscle Myoblasts Deteriorated by Diabetes Mellitus
  Shunichi Nakamura, Shinichi Yonekura, Takeshi Shimosato, Tomohide Takaya
  Frontiers in Physiology.2021;[Epub]     CrossRef
• Lipophorin receptor 1 (LpR1) in Drosophila muscle influences life span by regulating mitochondrial aging
  Ae-kyeong Kim, Dae-Woo Kwon, Eunbyul Yeom, Kwang-Pyo Lee, Ki-Sun Kwon, Kweon Yu, Kyu-Sun Lee
  Biochemical and Biophysical Research Communications.2021; 568: 95.     CrossRef
• Skeletal muscle thermogenesis enables aquatic life in the smallest marine mammal
  Traver Wright, Randall W. Davis, Heidi C. Pearson, Michael Murray, Melinda Sheffield-Moore
  Science.2021; 373(6551): 223.     CrossRef
• Myoglobin, expressed in brown adipose tissue of mice, regulates the content and activity of mitochondria and lipid droplets
  Mostafa A. Aboouf, Julia Armbruster, Markus Thiersch, Max Gassmann, Axel Gödecke, Erich Gnaiger, Glen Kristiansen, Anne Bicker, Thomas Hankeln, Hao Zhu, Thomas A. Gorr
  Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.2021; 1866(12): 159026.     CrossRef
• Skeletal muscle energy metabolism in obesity
  Abel M. Mengeste, Arild C. Rustan, Jenny Lund
  Obesity.2021; 29(10): 1582.     CrossRef
• Cellular senescence in musculoskeletal homeostasis, diseases, and regeneration
  Mei Wan, Elise F. Gray-Gaillard, Jennifer H. Elisseeff
  Bone Research.2021;[Epub]     CrossRef
• The small molecule SERCA activator CDN1163 increases energy metabolism in human skeletal muscle cells
  Abel M. Mengeste, Jenny Lund, Parmeshwar Katare, Roya Ghobadi, Hege G. Bakke, Per Kristian Lunde, Lars Eide, Gavin O’ Mahony, Sven Göpel, Xiao-Rong Peng, Eili Tranheim Kase, G. Hege Thoresen, Arild C. Rustan
  Current Research in Pharmacology and Drug Discovery.2021; 2: 100060.     CrossRef
• Antioxidant Properties and Cytoprotective Effect of Pistacia lentiscus L. Seed Oil against 7β-Hydroxycholesterol-Induced Toxicity in C2C12 Myoblasts: Reduction in Oxidative Stress, Mitochondrial and Peroxisomal Dysfunctions and Attenuation of Cell Death
  Imen Ghzaiel, Amira Zarrouk, Thomas Nury, Michela Libergoli, Francesca Florio, Souha Hammouda, Franck Ménétrier, Laure Avoscan, Aline Yammine, Mohammad Samadi, Norbert Latruffe, Stefano Biressi, Débora Levy, Sérgio Paulo Bydlowski, Sonia Hammami, Anne Vej
  Antioxidants.2021; 10(11): 1772.     CrossRef
• Role of Peroxisome Proliferator-Activated Receptors (PPARs) in Energy Homeostasis of Dairy Animals: Exploiting Their Modulation through Nutrigenomic Interventions
  Faiz-ul Hassan, Asif Nadeem, Zhipeng Li, Maryam Javed, Qingyou Liu, Jahanzaib Azhar, Muhammad Saif-ur Rehman, Kuiqing Cui, Saif ur Rehman
  International Journal of Molecular Sciences.2021; 22(22): 12463.     CrossRef
• Differential Effects of 25-Hydroxyvitamin D3 versus 1α 25-Dihydroxyvitamin D3 on Adipose Tissue Browning in CKD-Associated Cachexia
  Robert H. Mak, Uwe Querfeld, Alex Gonzalez, Sujana Gunta, Wai W. Cheung
  Cells.2021; 10(12): 3382.     CrossRef
• Effects of Starvation on Antioxidant-Related Signaling Molecules, Oxidative Stress, and Autophagy in Juvenile Chinese Perch Skeletal Muscle
  Ping Wu, Aimin Wang, Jia Cheng, Lin Chen, Yaxiong Pan, Honghui Li, Qi Zhang, Jiaqi Zhang, Wuying Chu, Jianshe Zhang
  Marine Biotechnology.2020; 22(1): 81.     CrossRef
• Thermogenic adipocytes: lineage, function and therapeutic potential
  Alice E. Pollard, David Carling
  Biochemical Journal.2020; 477(11): 2071.     CrossRef
• Hypoglycaemic effect of catalpol in a mouse model of high-fat diet-induced prediabetes
  Dengqiu Xu, Xiaofei Huang, Hozeifa M. Hassan, Lu Wang, Sijia Li, Zhenzhou Jiang, Luyong Zhang, Tao Wang
  Applied Physiology, Nutrition, and Metabolism.2020; 45(10): 1127.     CrossRef
• The evolution of mechanisms involved in vertebrate endothermy
  Lucas J. Legendre, Donald Davesne
  Philosophical Transactions of the Royal Society B: Biological Sciences.2020; 375(1793): 20190136.     CrossRef
• Uncoupling of sarcoendoplasmic reticulum calcium ATPase pump activity by sarcolipin as the basis for muscle non-shivering thermogenesis
  Naresh C. Bal, Muthu Periasamy
  Philosophical Transactions of the Royal Society B: Biological Sciences.2020; 375(1793): 20190135.     CrossRef
• Prediction of muscle mass in arms and legs based on 3D laser-based photonic body scans’ standard dimensions in a homogenous sample of young men
  Cristine Cavegn, Frank Rühli, Nicole Bender, Kaspar Staub
  Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization.2020; 8(5): 562.     CrossRef
• Thermogenesis in Adipose Tissue Activated by Thyroid Hormone
  Winifred W. Yau, Paul M. Yen
  International Journal of Molecular Sciences.2020; 21(8): 3020.     CrossRef
• Interaction of a Sarcolipin Pentamer and Monomer with the Sarcoplasmic Reticulum Calcium Pump, SERCA
  John Paul Glaves, Joseph O. Primeau, Przemek A. Gorski, L. Michel Espinoza-Fonseca, M. Joanne Lemieux, Howard S. Young
  Biophysical Journal.2020; 118(2): 518.     CrossRef
• Automated CT-derived skeletal muscle mass determination in lower hind limbs of mice using a 3D U-Net deep learning network
  Brent van der Heyden, Wouter R. P. H. van de Worp, Ardy van Helvoort, Jan Theys, Annemie M. W. J. Schols, Ramon C. J. Langen, Frank Verhaegen
  Journal of Applied Physiology.2020; 128(1): 42.     CrossRef
• Modified creatinine index and risk for long-term infection-related mortality in hemodialysis patients: ten-year outcomes of the Q-Cohort Study
  Hokuto Arase, Shunsuke Yamada, Hiroto Hiyamuta, Masatomo Taniguchi, Masanori Tokumoto, Kazuhiko Tsuruya, Toshiaki Nakano, Takanari Kitazono
  Scientific Reports.2020;[Epub]     CrossRef
• Ticking for Metabolic Health: The Skeletal‐Muscle Clocks
  Miguel A. Gutierrez‐Monreal, Jan‐Frieder Harmsen, Patrick Schrauwen, Karyn A. Esser
  Obesity.2020;[Epub]     CrossRef
• Gut microbiota and regulation of myokine-adipokine function
  Francesco Suriano, Matthias Van Hul, Patrice D Cani
  Current Opinion in Pharmacology.2020; 52: 9.     CrossRef
• P2X7 Receptor in the Management of Energy Homeostasis: Implications for Obesity, Dyslipidemia, and Insulin Resistance
  Roberto Coccurello, Cinzia Volonté
  Frontiers in Endocrinology.2020;[Epub]     CrossRef
• Primary Active Ca2+ Transport Systems in Health and Disease
  Jialin Chen, Aljona Sitsel, Veronick Benoy, M. Rosario Sepúlveda, Peter Vangheluwe
  Cold Spring Harbor Perspectives in Biology.2020; 12(2): a035113.     CrossRef
• Sex‐specific alterations in whole body energetics and voluntary activity in heterozygous R163C malignant hyperthermia‐susceptible mice
  Jennifer M. Rutkowsky, Trina A. Knotts, Paul D. Allen, Isaac N. Pessah, Jon J. Ramsey
  The FASEB Journal.2020; 34(6): 8721.     CrossRef
• The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review
  Adrian M. Gonzalez-Gil, Leticia Elizondo-Montemayor
  Nutrients.2020; 12(6): 1899.     CrossRef
• Emergent Coordination of the CHKB and CPT1B Genes in Eutherian Mammals: Implications for the Origin of Brown Adipose Tissue
  Bhavin V. Patel, Fanrong Yao, Aidan Howenstine, Risa Takenaka, Jacob A. Hyatt, Karen E. Sears, Brian M. Shewchuk
  Journal of Molecular Biology.2020; 432(23): 6127.     CrossRef
• Chronic cold exposure induces mitochondrial plasticity in deer mice native to high altitudes
  Sajeni Mahalingam, Zachary A. Cheviron, Jay F. Storz, Grant B. McClelland, Graham R. Scott
  The Journal of Physiology.2020; 598(23): 5411.     CrossRef
• Adaptive thermogenesis enhances the life-threatening response to heat in mice with an Ryr1 mutation
  Hui J. Wang, Chang Seok Lee, Rachel Sue Zhen Yee, Linda Groom, Inbar Friedman, Lyle Babcock, Dimitra K. Georgiou, Jin Hong, Amy D. Hanna, Joseph Recio, Jong Min Choi, Ting Chang, Nadia H. Agha, Jonathan Romero, Poonam Sarkar, Nicol Voermans, M. Waleed Gab
  Nature Communications.2020;[Epub]     CrossRef
• Sclerostin Influences Exercise-Induced Adaptations in Body Composition and White Adipose Tissue Morphology in Male Mice
  Nigel Kurgan, Joshua Stoikos, Bradley J. Baranowski, Jenalyn Yumol, Roopan Dhaliwal, Jake B. Sweezey-Munroe, Val A. Fajardo, William Gittings, Rebecca E.K. Macpherson, Panagiota Klentrou
  Journal of Bone and Mineral Research.2020; 38(4): 541.     CrossRef
• Mitochondrial dysfunction and inhibition of myoblast differentiation in mice with high‐fat‐diet‐induced pre‐diabetes
  Dengqiu Xu, Zhenzhou Jiang, Zeren Sun, Lu Wang, Guolin Zhao, Hozeifa M. Hassan, Sisi Fan, Wang Zhou, Shuangshuang Han, Luyong Zhang, Tao Wang
  Journal of Cellular Physiology.2019; 234(5): 7510.     CrossRef
• Noninvasive and in vivo assessment of upper and lower limb skeletal muscle oxidative metabolism activity and microvascular responses to glucose ingestion in humans
  Rogério Nogueira Soares, Alessandro L. Colosio, Juan Manuel Murias, Silvia Pogliaghi
  Applied Physiology, Nutrition, and Metabolism.2019; 44(10): 1105.     CrossRef
• Fpr2 Deficiency Alleviates Diet-Induced Insulin Resistance Through Reducing Body Weight Gain and Inhibiting Inflammation Mediated by Macrophage Chemotaxis and M1 Polarization
  Xiaofang Chen, Shu Zhuo, Tengfei Zhu, Pengle Yao, Mengmei Yang, Hong Mei, Na Li, Fengguang Ma, Ji Ming Wang, Shiting Chen, Richard D. Ye, Yu Li, Yingying Le
  Diabetes.2019; 68(6): 1130.     CrossRef
• Taurine protects against arsenic trioxide-induced insulin resistance via ROS-Autophagy pathway in skeletal muscle
  Lei Yang, Tianming Qiu, Xiaofeng Yao, Liping Jiang, Sen Wei, Pei Pei, Zhidong Wang, Jie Bai, Xiaofang Liu, Guang Yang, Shuang Liu, Xiance Sun
  The International Journal of Biochemistry & Cell Biology.2019; 112: 50.     CrossRef
• Increased triacylglycerol - Fatty acid substrate cycling in human skeletal muscle cells exposed to eicosapentaenoic acid
  Nils G. Løvsletten, Siril S. Bakke, Eili T. Kase, D. Margriet Ouwens, G. Hege Thoresen, Arild C. Rustan, Juan J. Loor
  PLOS ONE.2018; 13(11): e0208048.     CrossRef
• Transient receptor potential (TRP) channels: a metabolic TR(i)P to obesity prevention and therapy
  M. Bishnoi, P. Khare, L. Brown, S. K. Panchal
  Obesity Reviews.2018; 19(9): 1269.     CrossRef
• Pivotal Roles of Peroxisome Proliferator-Activated Receptors (PPARs) and Their Signal Cascade for Cellular and Whole-Body Energy Homeostasis
  Shreekrishna Lamichane, Babita Dahal Lamichane, Sang-Mo Kwon
  International Journal of Molecular Sciences.2018; 19(4): 949.     CrossRef
• Antiobesity Effect of Astilbe chinensis Franch. et Savet. Extract through Regulation of Adipogenesis and AMP‐Activated Protein Kinase Pathways in 3T3‐L1 Adipocyte and High‐Fat Diet‐Induced C57BL/6N Obese Mice
  Xian Hua Zhang, Zhiqiang Wang, Bueom-Goo Kang, Seung Hwan Hwang, Jae-Young Lee, Soon Sung Lim, Bo Huang, Toshiaki Makino
  Evidence-Based Complementary and Alternative Medicine.2018;[Epub]     CrossRef
• Loss of P2X7 receptor function dampens whole body energy expenditure and fatty acid oxidation
  Giacomo Giacovazzo, Savina Apolloni, Roberto Coccurello
  Purinergic Signalling.2018; 14(3): 299.     CrossRef
• Chromatin and Metabolism
  Tamaki Suganuma, Jerry L. Workman
  Annual Review of Biochemistry.2018; 87(1): 27.     CrossRef
• Zebrafish as a Model for Obesity and Diabetes
  Liqing Zang, Lisette A. Maddison, Wenbiao Chen
  Frontiers in Cell and Developmental Biology.2018;[Epub]     CrossRef
• Comparison between Dual-Energy X-ray Absorptiometry and Bioelectrical Impedance Analyses for Accuracy in Measuring Whole Body Muscle Mass and Appendicular Skeletal Muscle Mass
  Seo Young Lee, Soyeon Ahn, Young Ji Kim, Myoung Jin Ji, Kyoung Min Kim, Sung Hee Choi, Hak Chul Jang, Soo Lim
  Nutrients.2018; 10(6): 738.     CrossRef