Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal

Search
OPEN ACCESS

Author index

Page Path
HOME > Browse > Author index
Search
Jiyin Zhou 1 Article
Pathophysiology
Glial and Vascular Cell Regulation of the Blood-Brain Barrier in Diabetes
Xiaolong Li, Yan Cai, Zuo Zhang, Jiyin Zhou
Diabetes Metab J. 2022;46(2):222-238.   Published online March 18, 2022
DOI: https://doi.org/10.4093/dmj.2021.0146
  • 6,580 View
  • 314 Download
  • 13 Web of Science
  • 14 Crossref
AbstractAbstract PDFPubReader   ePub   
As a structural barrier, the blood-brain barrier (BBB) is located at the interface between the brain parenchyma and blood, and modulates communication between the brain and blood microenvironment to maintain homeostasis. The BBB is composed of endothelial cells, basement membrane, pericytes, and astrocytic end feet. BBB impairment is a distinguishing and pathogenic factor in diabetic encephalopathy. Diabetes causes leakage of the BBB through downregulation of tight junction proteins, resulting in impaired functioning of endothelial cells, pericytes, astrocytes, microglia, nerve/glial antigen 2-glia, and oligodendrocytes. However, the temporal regulation, mechanisms of molecular and signaling pathways, and consequences of BBB impairment in diabetes are not well understood. Consequently, the efficacy of therapies diabetes targeting BBB leakage still lags behind the requirements. This review summarizes the recent research on the effects of diabetes on BBB composition and the potential roles of glial and vascular cells as therapeutic targets for BBB disruption in diabetic encephalopathy.

Citations

Citations to this article as recorded by  
  • Gut microbiota and type 2 diabetes mellitus: a focus on the gut-brain axis
    Yi Pan, Tong Bu, Xia Deng, Jue Jia, Guoyue Yuan
    Endocrine.2024; 84(1): 1.     CrossRef
  • Long-Term Exposure of Cultured Astrocytes to High Glucose Impact on Their LPS-Induced Activation
    Ayna Abdyeva, Ekaterina Kurtova, Irina Savinkova, Maksim Galkov, Liubov Gorbacheva
    International Journal of Molecular Sciences.2024; 25(2): 1122.     CrossRef
  • Role of autophagy in angiogenic potential of vascular pericytes
    Soheil Zamen Milani, Aysa Rezabakhsh, Mohammad Karimipour, Leila Salimi, Narges Mardi, Maryam Taghavi Narmi, Fatemeh Sadeghsoltani, Ferzane Valioglu, Reza Rahbarghazi
    Frontiers in Cell and Developmental Biology.2024;[Epub]     CrossRef
  • Hyperglycaemia perturbs blood-brain barrier integrity through its effects on endothelial cell characteristics and function
    Arshad Hashmat, Jingyuan Ya, Rais Kadir, Mansour Alwjwaj, Ulvi Bayraktutan
    Tissue Barriers.2024;[Epub]     CrossRef
  • Endothelial dysfunction in neurodegenerative disease: Is endothelial inflammation an overlooked druggable target?
    Megan Ritson, Caroline P.D. Wheeler-Jones, Helen B. Stolp
    Journal of Neuroimmunology.2024; 391: 578363.     CrossRef
  • The NG2-glia is a potential target to maintain the integrity of neurovascular unit after acute ischemic stroke
    Xiaoyan Hu, Panpan Geng, Xiaoyun Zhao, Qian Wang, Changqing Liu, Chun Guo, Wen Dong, Xinchun Jin
    Neurobiology of Disease.2023; 180: 106076.     CrossRef
  • Tight junction disruption and the pathogenesis of the chronic complications of diabetes mellitus: A narrative review
    Ma Ludivina Robles-Osorio, Ernesto Sabath
    World Journal of Diabetes.2023; 14(7): 1013.     CrossRef
  • Function and therapeutic value of astrocytes in diabetic cognitive impairment
    Fanyu Meng, Jiafeng Fu, Lin Zhang, Mengqing Guo, Pengwei Zhuang, Qingsheng Yin, Yanjun Zhang
    Neurochemistry International.2023; 169: 105591.     CrossRef
  • Exploring the Molecular Targets for Type 2 Diabetes-Induced Alzheimer’s Disease Through Bioinformatics Analysis
    Lin Gao, Chengyu Huang, Hui Li, Shidi Wu, Xiaoyan Zhou, Changjiang Ying
    Epigenomics.2023; 15(11): 619.     CrossRef
  • In vivo retinal imaging is associated with cognitive decline, blood-brain barrier disruption and neuroinflammation in type 2 diabetic mice
    May Majimbi, Samuel McLenachan, Michael Nesbit, Fred K. Chen, Virginie Lam, John Mamo, Ryu Takechi
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Diabetic microvascular disease in non-classical beds: the hidden impact beyond the retina, the kidney, and the peripheral nerves
    Dídac Mauricio, Mònica Gratacòs, Josep Franch-Nadal
    Cardiovascular Diabetology.2023;[Epub]     CrossRef
  • Transcranial photobiomodulation improves insulin therapy in diabetic microglial reactivity and the brain drainage system
    Shaojun Liu, Dongyu Li, Tingting Yu, Jingtan Zhu, Oxana Semyachkina-Glushkovskaya, Dan Zhu
    Communications Biology.2023;[Epub]     CrossRef
  • NG2‐glia crosstalk with microglia in health and disease
    Zuo Zhang, Xiaolong Li, Hongli Zhou, Jiyin Zhou
    CNS Neuroscience & Therapeutics.2022; 28(11): 1663.     CrossRef
  • Accelerated amyloid angiopathy and related vascular alterations in a mixed murine model of Alzheimer´s disease and type two diabetes
    Maria Vargas-Soria, Juan Jose Ramos-Rodriguez, Angel del Marco, Carmen Hierro-Bujalance, Maria Jose Carranza-Naval, Maria Calvo-Rodriguez, Susanne J. van Veluw, Alan W. Stitt, Rafael Simó, Brian J. Bacskai, Carmen Infante-Garcia, Monica Garcia-Alloza
    Fluids and Barriers of the CNS.2022;[Epub]     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal