Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal


Author index

Page Path
HOME > Browse > Author index
Jing Chen  (Chen J) 1 Article
Diabetic Cardiomyopathy and Its Prevention by Nrf2: Current Status
Jing Chen, Zhiguo Zhang, Lu Cai
Diabetes Metab J. 2014;38(5):337-345.   Published online October 17, 2014
  • 5,465 View
  • 56 Download
  • 76 Web of Science
  • 76 Crossref
AbstractAbstract PDFPubReader   

Diabetic cardiomyopathy (DCM), as one of the major cardiac complications in diabetic patients, is known to related with oxidative stress that is due to a severe imbalance between reactive oxygen species (ROS) and/or reactive nitrogen species (RNS) generation and their clearance by antioxidant defense systems. Transcription factor nuclear factor NF-E2-related factor 2 (Nrf2) plays an important role in maintaining the oxidative homeostasis by regulating multiple downstream antioxidants. Diabetes may up-regulate several antioxidants in the heart as a compensative mechanism at early stage, but at late stage, diabetes not only generates extra ROS and/or RNS but also impairs antioxidant capacity in the heart, including Nrf2. In an early study, we have established that Nrf2 protect the cardiac cells and heart from high level of glucose in vitro and hyperglycemia in vivo, and in the following study demonstrated the significant down-regulation of cardiac Nrf2 expression in diabetic animals and patients. Using Nrf2-KO mice or Nrf2 inducers, blooming evidence has indicated the important protection by Nrf2 from cardiac pathogenesis in the diabetes. Therefore, this brief review summarizes the status of studies on Nrf2's role in preventing DCM and even other complications, the need for new and safe Nrf2 inducer screening and the precaution for the undesirable side of Nrf2 under certain conditions.


Citations to this article as recorded by  
  • Beyond Hepatoprotection—The Cardioprotective Effects of Bicyclol in Diabetes
    Arun Samidurai, Rakesh C. Kukreja
    Cardiovascular Drugs and Therapy.2024; 38(3): 411.     CrossRef
  • Natural Products and Health
    Joanna Bartkowiak-Wieczorek, Edyta Mądry
    Nutrients.2024; 16(3): 415.     CrossRef
  • Nrf2 prevents diabetic cardiomyopathy via antioxidant effect and normalization of glucose and lipid metabolism in the heart
    Ge Yang, Qihe Zhang, Chao Dong, Guowen Hou, Jinjie Li, Xin Jiang, Ying Xin
    Journal of Cellular Physiology.2024;[Epub]     CrossRef
  • 3,4′,5-Trimethoxy-trans-stilbene ameliorates hepatic insulin resistance and oxidative stress in diabetic obese mice through insulin and Nrf2 signaling pathways
    Yi Tan, Chunxiu Zhou, Lingchao Miao, Xutao Zhang, Haroon Khan, Baojun Xu, Wai San Cheang
    Food & Function.2024; 15(6): 2996.     CrossRef
  • The signaling pathways of selected traditional Chinese medicine prescriptions and their metabolites in the treatment of diabetic cardiomyopathy: a review
    Wencan Li, Xiang Liu, Zheng Liu, Qichang Xing, Renzhu Liu, Qinxuan Wu, Yixiang Hu, Jiani Zhang
    Frontiers in Pharmacology.2024;[Epub]     CrossRef
  • Natural compounds protect against the pathogenesis of osteoarthritis by mediating the NRF2/ARE signaling
    Zhenyu Wu, Zhouxin Yang, Luying Liu, Yong Xiao
    Frontiers in Pharmacology.2023;[Epub]     CrossRef
  • High fat diet exacerbates long-term metabolic, neuropathological, and behavioral derangements in an experimental mouse model of traumatic brain injury
    Stanley Ibeh, Nour-Mounira Z. Bakkar, Fatima Ahmad, Judith Nwaiwu, Chloe Barsa, Sarine Mekhjian, Mohammad Amine Reslan, Ali H. Eid, Hayat Harati, Sanaa Nabha, Yehia Mechref, Ahmed F. El-Yazbi, Firas Kobeissy
    Life Sciences.2023; 314: 121316.     CrossRef
  • The Protective Effect of 11-Keto-β-Boswellic Acid against Diabetic Cardiomyopathy in Rats Entails Activation of AMPK
    Jozaa Z. AlTamimi, Nora A. AlFaris, Ghedeir M. Alshammari, Reham I. Alagal, Dalal H. Aljabryn, Mohammed Abdo Yahya
    Nutrients.2023; 15(7): 1660.     CrossRef
  • Caffeic Acid Phenethyl Ester and Caffeamide Derivatives Suppress Oral Squamous Cell Carcinoma Cells
    Yin-Hwa Shih, Chieh-Chieh Chen, Yueh-Hsiung Kuo, Lih-Jyh Fuh, Wan-Chen Lan, Tong-Hong Wang, Kuo-Chou Chiu, Thanh-Hien Vu Nguyen, Shih-Min Hsia, Tzong-Ming Shieh
    International Journal of Molecular Sciences.2023; 24(12): 9819.     CrossRef
  • The Role of Asiatic Acid in Preventing Dental Pulp Inflammation: An in-vivo Study
    Arlina Nurhapsari, Risya Cilmiaty, Adi Prayitno, Bambang Purwanto, Soetrisno Soetrisno
    Clinical, Cosmetic and Investigational Dentistry.2023; Volume 15: 109.     CrossRef
  • Dexmedetomidine ameliorates diabetic cardiomyopathy by inhibiting ferroptosis through the Nrf2/GPX4 pathway
    Fan Li, Zhenfei Hu, Yidan Huang, Haiting Zhan
    Journal of Cardiothoracic Surgery.2023;[Epub]     CrossRef
  • Metformin-mediated epigenetic modifications in diabetes and associated conditions: Biological and clinical relevance
    Roberta Giordo, Anna Maria Posadino, Arduino Aleksander Mangoni, Gianfranco Pintus
    Biochemical Pharmacology.2023; 215: 115732.     CrossRef
  • Transient receptor potential vanilloid type 1: cardioprotective effects in diabetic models
    Jiaqi Bao, Zhicheng Gao, Yilan Hu, Lifang Ye, Lihong Wang
    Channels.2023;[Epub]     CrossRef
  • Sinapic acid ameliorates cardiac dysfunction and cardiomyopathy by modulating NF-κB and Nrf2/HO-1 signaling pathways in streptozocin induced diabetic rats
    Mohammad Raish, Ajaz Ahmad, Yousef A. Bin Jardan, Mudassar Shahid, Khalid M. Alkharfy, Abdul Ahad, Mushtaq Ahmad Ansari, Ibrahim Abdelsalam Abdelrahman, Fahad I. Al-Jenoobi
    Biomedicine & Pharmacotherapy.2022; 145: 112412.     CrossRef
  • Recent Advances in KEAP1/NRF2-Targeting Strategies by Phytochemical Antioxidants, Nanoparticles, and Biocompatible Scaffolds for the Treatment of Diabetic Cardiovascular Complications
    Andrea Rampin, Michele Carrabba, Martina Mutoli, Charlotte L. Eman, Gianluca Testa, Paolo Madeddu, Gaia Spinetti
    Antioxidants & Redox Signaling.2022; 36(10-12): 707.     CrossRef
  • Exercise and Urtica Dioica extract ameliorate mitochondrial function and the expression of cardiac muscle Nuclear Respiratory Factor 2 and Peroxisome proliferator-activated receptor Gamma Coactivator 1-alpha in STZ-induced diabetic rats
    Seyyedeh Masoumeh Seyydi, Asghar Tofighi, Masoud Rahmati, Javad Tolouei Azar
    Gene.2022; 822: 146351.     CrossRef
  • 3,3′,4,5′-Tetramethoxy-trans-stilbene Improves Insulin Resistance by Activating the IRS/PI3K/Akt Pathway and Inhibiting Oxidative Stress
    Yi Tan, Lingchao Miao, Jianbo Xiao, Wai San Cheang
    Current Issues in Molecular Biology.2022; 44(5): 2175.     CrossRef
  • The Beneficial Effects of Chinese Herbal Monomers on Ameliorating Diabetic Cardiomyopathy via Nrf2 Signaling
    Yiwei Gao, Wu Liu, Xin Su, Xinyi Li, Fangning Yu, Ning Zhang, Yuli Huang
    Oxidative Medicine and Cellular Longevity.2022; 2022: 1.     CrossRef
  • Cardioprotective Effects and in-silico Antioxidant Mechanism of L-Ergothioneine in Experimental Type-2 Diabetic Rats
    Ayobami Dare, Ahmed A Elrashedy, Mahendra L. Channa, Anand Nadar
    Cardiovascular & Hematological Agents in Medicinal Chemistry.2022; 20(2): 133.     CrossRef
  • Molecular Mechanisms of Ferroptosis and Relevance to Cardiovascular Disease
    Lai-Hua Xie, Nadezhda Fefelova, Sri Harika Pamarthi, Judith K. Gwathmey
    Cells.2022; 11(17): 2726.     CrossRef
  • Cardiac adaptation and cardioprotection against arrhythmias and ischemia-reperfusion injury in mammalian hibernators
    Lai-Hua Xie, Judith K. Gwathmey, Zhenghang Zhao
    Pflügers Archiv - European Journal of Physiology.2021; 473(3): 407.     CrossRef
  • Cardioprotective Effect of Glycyrrhizin on Myocardial Remodeling in Diabetic Rats
    Vikram Thakur, Narah Alcoreza, Monica Delgado, Binata Joddar, Munmun Chattopadhyay
    Biomolecules.2021; 11(4): 569.     CrossRef
  • Therapeutic potential of targeting oxidative stress in diabetic cardiomyopathy
    Nikole J. Byrne, Namakkal S. Rajasekaran, E Dale Abel, Heiko Bugger
    Free Radical Biology and Medicine.2021; 169: 317.     CrossRef
  • Punicalagin Protects Against Diabetic Cardiomyopathy by Promoting Opa1-Mediated Mitochondrial Fusion via Regulating PTP1B-Stat3 Pathway
    Feng Fu, Chaoyang Liu, Rui Shi, Man Li, Min Zhang, Yanyan Du, Qiaojuan Wang, Jun Li, Guoen Wang, Jianming Pei, Mingge Ding
    Antioxidants & Redox Signaling.2021; 35(8): 618.     CrossRef
  • Elevated type I interferon responses potentiate metabolic dysfunction, inflammation, and accelerated aging in mtDNA mutator mice
    Yuanjiu Lei, Camila Guerra Martinez, Sylvia Torres-Odio, Samantha L. Bell, Christine E. Birdwell, Joshua D. Bryant, Carl W. Tong, Robert O. Watson, Laura Ciaccia West, A. Phillip West
    Science Advances.2021;[Epub]     CrossRef
  • The potential role of Keap1-Nrf2 pathway in the pathogenesis of Alzheimer’s disease, type 2 diabetes, and type 2 diabetes-related Alzheimer’s disease
    Ling He, Yi Sun
    Metabolic Brain Disease.2021; 36(7): 1469.     CrossRef
  • The impact of mitochondria on cancer treatment resistance
    Michelle van der Merwe, Gustav van Niekerk, Carla Fourie, Manisha du Plessis, Anna-Mart Engelbrecht
    Cellular Oncology.2021; 44(5): 983.     CrossRef
  • Therapeutic Approaches Targeting Proteostasis in Kidney Disease and Fibrosis
    Jia-Huang Chen, Chia-Hsien Wu, Chih-Kang Chiang
    International Journal of Molecular Sciences.2021; 22(16): 8674.     CrossRef
  • Coronary Large Conductance Ca2+-Activated K+ Channel Dysfunction in Diabetes Mellitus
    Tong Lu, Hon-Chi Lee
    Frontiers in Physiology.2021;[Epub]     CrossRef
  • Ferroptosis: New Dawn for Overcoming the Cardio-Cerebrovascular Diseases
    Meng-Yi Luo, Jian-Hui Su, Shao-Xin Gong, Na Liang, Wen-Qian Huang, Wei Chen, Ai-Ping Wang, Ying Tian
    Frontiers in Cell and Developmental Biology.2021;[Epub]     CrossRef
  • Recombinant Human Growth Hormone Inhibits Lipotoxicity, Oxidative Stress, and Apoptosis in a Mouse Model of Diabetic Cardiomyopathy
    Zuowei Pei, Xiang Wang, Chenguang Yang, Min Dong, Fang Wang, Juan Gambini
    Oxidative Medicine and Cellular Longevity.2021; 2021: 1.     CrossRef
  • Hydrogen sulfide mitigates myocardial inflammation by inhibiting nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome activation in diabetic rats
    Qiang Jia, Shomaila Mehmood, Xiaofen Liu, Shanfeng Ma, Rui Yang
    Experimental Biology and Medicine.2020; 245(3): 221.     CrossRef
  • Heme oxygenase-1 in protozoan infections: A tale of resistance and disease tolerance
    Rafael C. M. C. Silva, Leonardo H. Travassos, Claudia N. Paiva, Marcelo T. Bozza, Marc-Jan Gubbels
    PLOS Pathogens.2020; 16(7): e1008599.     CrossRef
  • Distinct Approaches of Raloxifene: Its Far-Reaching Beneficial Effects Implicating the HO-System
    Denise Börzsei, Renáta Szabó, Alexandra Hoffmann, Médea Veszelka, Imre Pávó, Zsolt Turcsán, Csaba Viczián, Krisztina Kupai, Csaba Varga, Anikó Pósa
    Biomolecules.2020; 10(3): 375.     CrossRef
  • The Mitochondria: A Target of Polyphenols in the Treatment of Diabetic Cardiomyopathy
    Humna Bhagani, Suzanne A. Nasser, Ali Dakroub, Ahmed F. El-Yazbi, Assaad A. Eid, Firas Kobeissy, Gianfranco Pintus, Ali H. Eid
    International Journal of Molecular Sciences.2020; 21(14): 4962.     CrossRef
  • The Effects of Dietary Supplements that Overactivate the Nrf2/ARE System
    Robert E. Smith
    Current Medicinal Chemistry.2020; 27(13): 2077.     CrossRef
  • Allopurinol reduces oxidative stress and activates Nrf2/p62 to attenuate diabetic cardiomyopathy in rats
    Jierong Luo, Dan Yan, Sisi Li, Shiming Liu, Fei Zeng, Chi Wai Cheung, Hong Liu, Michael G. Irwin, Huansen Huang, Zhengyuan Xia
    Journal of Cellular and Molecular Medicine.2020; 24(2): 1760.     CrossRef
  • Rg1 protects H9C2 cells from high glucose‐/palmitate‐induced injury via activation of AKT/GSK‐3β/Nrf2 pathway
    Haitao Yu, Juan Zhen, Yang Yang, Jian Du, Jiyan Leng, Qian Tong
    Journal of Cellular and Molecular Medicine.2020; 24(14): 8194.     CrossRef
  • Ranolazine protects against diabetic cardiomyopathy by activating the NOTCH1/NRG1 pathway
    Xi Chen, Long Ren, Xing Liu, Xi Sun, Chaorun Dong, Yanan Jiang, Ying Qin, Huan Qu, Jinfeng Jiao, Shuo Wang, Yunlong Bai, Baofeng Yang
    Life Sciences.2020; 261: 118306.     CrossRef
  • Low Concentration of Withaferin a Inhibits Oxidative Stress-Mediated Migration and Invasion in Oral Cancer Cells
    Tzu-Jung Yu, Jen-Yang Tang, Fu Ou-Yang, Yen-Yun Wang, Shyng-Shiou F. Yuan, Kevin Tseng, Li-Ching Lin, Hsueh-Wei Chang
    Biomolecules.2020; 10(5): 777.     CrossRef
  • Protective Effect of Simplicillium sp. Ethyl Acetate Extract against High Glucose-Induced Oxidative Stress in HUVECs
    Ting-Ting Tian, Qi-Rui Li, Shi-Quan Gan, Chu-Rui Chang, Xiang-Chun Shen
    Evidence-Based Complementary and Alternative Medicine.2020; 2020: 1.     CrossRef
  • Deneysel Diyabet Oluşturulan Sıçanlarda Kalp ve İskelet Kası Nrf2 Yapımı ve Oksidatif Stres Üzerine Melatoninin Etkisinin İncelenmesi
    Turkish Journal of Diabetes and Obesity.2020; 4(1): 46.     CrossRef
  • Nicorandil alleviates apoptosis in diabetic cardiomyopathy through PI3K/Akt pathway
    Xuyang Wang, Jinyu Pan, Dian Liu, Mingjun Zhang, Xiaowei Li, Jingjing Tian, Ming Liu, Tao Jin, Fengshuang An
    Journal of Cellular and Molecular Medicine.2019; 23(8): 5349.     CrossRef
  • Bailcalin Protects against Diabetic Cardiomyopathy through Keap1/Nrf2/AMPK-Mediated Antioxidative and Lipid-Lowering Effects
    Ran Li, Yuan Liu, Ying-guang Shan, Lu Gao, Fang Wang, Chun-guang Qiu
    Oxidative Medicine and Cellular Longevity.2019; 2019: 1.     CrossRef
  • Omega 3 rich diet modulates energy metabolism via GPR120-Nrf2 crosstalk in a novel antioxidant mouse model
    Deborah Amos, Carla Cook, Nalini Santanam
    Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.2019; 1864(4): 466.     CrossRef
  • Increased placental expressions of nuclear factor erythroid 2–related factor 2 and antioxidant enzymes in gestational diabetes: Protective mechanisms against the placental oxidative stress?
    Balachandiran Manoharan, Zachariah Bobby, Gowri Dorairajan, Sajini Elizabeth Jacob, Victorraj Gladwin, Vickneshwaran Vinayagam, Rajaa Muthu Packirisamy
    European Journal of Obstetrics & Gynecology and Reproductive Biology.2019; 238: 78.     CrossRef
  • Another look at phenolic compounds in cancer therapy the effect of polyphenols on ubiquitin-proteasome system
    Aleksandra Golonko, Tomasz Pienkowski, Renata Swislocka, Ryszard Lazny, Marek Roszko, Wlodzimierz Lewandowski
    European Journal of Medicinal Chemistry.2019; 167: 291.     CrossRef
  • Hydrogen sulfide-mediated regulation of cell death signaling ameliorates adverse cardiac remodeling and diabetic cardiomyopathy
    Sumit Kar, Tyler N. Kambis, Paras K. Mishra
    American Journal of Physiology-Heart and Circulatory Physiology.2019; 316(6): H1237.     CrossRef
  • Genomic and Genetic Approaches to Deciphering Acute Respiratory Distress Syndrome Risk and Mortality
    Heather Lynn, Xiaoguang Sun, Nancy Casanova, Manuel Gonzales-Garay, Christian Bime, Joe G.N. Garcia
    Antioxidants & Redox Signaling.2019; 31(14): 1027.     CrossRef
  • Enhanced Keap1-Nrf2 signaling protects the myocardium from isoproterenol-induced pathological remodeling in mice
    Gobinath Shanmugam, Anil Kumar Challa, Silvio H. Litovsky, Asokan Devarajan, Ding Wang, Dean P. Jones, Victor M. Darley-Usmar, Namakkal Soorappan Rajasekaran
    Redox Biology.2019; 27: 101212.     CrossRef
  • Effects of PP2A/Nrf2 on experimental diabetes mellitus-related cardiomyopathy by regulation of autophagy and apoptosis through ROS dependent pathway
    Yanhui Guan, Lichun Zhou, Yu Zhang, Huiqin Tian, Anqi Li, Xiuzhen Han
    Cellular Signalling.2019; 62: 109339.     CrossRef
  • An Aza resveratrol–chalcone derivative 6b protects mice against diabetic cardiomyopathy by alleviating inflammation and oxidative stress
    Shengban You, Jianchang Qian, Chuchu Sun, Hailing Zhang, Shiju Ye, Taiwei Chen, Zheng Xu, Jingying Wang, Weijian Huang, Guang Liang
    Journal of Cellular and Molecular Medicine.2018; 22(3): 1931.     CrossRef
  • Oxidative Stress in Mesenchymal Stem Cell Senescence: Regulation by Coding and Noncoding RNAs
    Rosa Vono, Eva Jover Garcia, Gaia Spinetti, Paolo Madeddu
    Antioxidants & Redox Signaling.2018; 29(9): 864.     CrossRef
  • An overview of the emerging interface between cardiac metabolism, redox biology and the circadian clock
    Rodrigo A. Peliciari-Garcia, Victor Darley-Usmar, Martin E. Young
    Free Radical Biology and Medicine.2018; 119: 75.     CrossRef
  • Klotho protects the heart from hyperglycemia-induced injury by inactivating ROS and NF-κB-mediated inflammation both in vitro and in vivo
    Yue Guo, Xiaodong Zhuang, Zena Huang, Jing Zou, Daya Yang, Xun Hu, Zhimin Du, Lichun Wang, Xinxue Liao
    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2018; 1864(1): 238.     CrossRef
  • Paradoxical cardiotoxicity of intraperitoneally-injected epigallocatechin gallate preparation in diabetic mice
    Nora O. Abdel Rasheed, Lamiaa A. Ahmed, Dalaal M. Abdallah, Bahia M. El-Sayeh
    Scientific Reports.2018;[Epub]     CrossRef
  • Oxidative stress-induced miR-27a targets the redox gene nuclear factor erythroid 2-related factor 2 in diabetic embryopathy
    Yang Zhao, Daoyin Dong, E. Albert Reece, Ashley R. Wang, Peixin Yang
    American Journal of Obstetrics and Gynecology.2018; 218(1): 136.e1.     CrossRef
  • Regulation on SIRT1-PGC-1α/Nrf2 pathway together with selective inhibition of aldose reductase makes compound hr5F a potential agent for the treatment of diabetic complications
    Zhihua Wang, Sheng Yuan, Yanbing Li, Zhe Zhang, Wei Xiao, Dan Tang, Kaihe Ye, Zhijun Liu, Congcong Wang, Yixiong Zheng, Hong Nie, Heru Chen
    Biochemical Pharmacology.2018; 150: 54.     CrossRef
  • Fibroblast growth factor-21 prevents diabetic cardiomyopathy via AMPK-mediated antioxidation and lipid-lowering effects in the heart
    Hong Yang, Anyun Feng, Sundong Lin, Lechu Yu, Xiufei Lin, Xiaoqing Yan, Xuemian Lu, Chi Zhang
    Cell Death & Disease.2018;[Epub]     CrossRef
  • Salusin-β contributes to oxidative stress and inflammation in diabetic cardiomyopathy
    Ming-Xia Zhao, Bing Zhou, Li Ling, Xiao-Qing Xiong, Feng Zhang, Qi Chen, Yue-Hua Li, Yu-Ming Kang, Guo-Qing Zhu
    Cell Death & Disease.2017; 8(3): e2690.     CrossRef
  • Role of Nrf2 Signaling in the Regulation of Vascular BK Channel β1 Subunit Expression and BK Channel Function in High-Fat Diet–Induced Diabetic Mice
    Tong Lu, Xiaojing Sun, Yong Li, Qiang Chai, Xiao-Li Wang, Hon-Chi Lee
    Diabetes.2017; 66(10): 2681.     CrossRef
  • Regulation of vascular large-conductance calcium-activated potassium channels by Nrf2 signalling
    Yong Li, Xiao-Li Wang, Xiaojing Sun, Qiang Chai, Jingchao Li, Benjamin Thompson, Win-Kuang Shen, Tong Lu, Hon-Chi Lee
    Diabetes and Vascular Disease Research.2017; 14(4): 353.     CrossRef
  • Metallothionein Is Downstream of Nrf2 and Partially Mediates Sulforaphane Prevention of Diabetic Cardiomyopathy
    Junlian Gu, Yanli Cheng, Hao Wu, Lili Kong, Shudong Wang, Zheng Xu, Zhiguo Zhang, Yi Tan, Bradley B. Keller, Honglan Zhou, Yuehui Wang, Zhonggao Xu, Lu Cai
    Diabetes.2017; 66(2): 529.     CrossRef
  • Kimchi methanol extracts attenuate hepatic steatosis induced by high cholesterol diet in low-density lipoprotein receptor knockout mice through inhibition of endoplasmic reticulum stress
    Minji Woo, Mijeong Kim, Jeong Sook Noh, Yeong Ok Song
    Journal of Functional Foods.2017; 32: 218.     CrossRef
  • Aspalathin Protects the Heart against Hyperglycemia-Induced Oxidative Damage by Up-Regulating Nrf2 Expression
    Phiwayinkosi Dludla, Christo Muller, Elizabeth Joubert, Johan Louw, M. Essop, Kwazi Gabuza, Samira Ghoor, Barbara Huisamen, Rabia Johnson
    Molecules.2017; 22(1): 129.     CrossRef
  • Intermittent hypoxia-induced cardiomyopathy and its prevention by Nrf2 and metallothionein
    Shanshan Zhou, Xia Yin, Jingpeng Jin, Yi Tan, Daniel J. Conklin, Ying Xin, Zhiguo Zhang, Weixia Sun, Taixing Cui, Jun Cai, Yang Zheng, Lu Cai
    Free Radical Biology and Medicine.2017; 112: 224.     CrossRef
  • Inhibitory effects of rosmarinic acid on pterygium epithelial cells through redox imbalance and induction of extrinsic and intrinsic apoptosis
    Ya-Yu Chen, Chia-Fang Tsai, Ming-Chu Tsai, Yu-Wen Hsu, Fung-Jou Lu
    Experimental Eye Research.2017; 160: 96.     CrossRef
  • Ischemia reperfusion injury, ischemic conditioning and diabetes mellitus
    Anne Lejay, Fei Fang, Rohan John, Julie A.D. Van, Meredith Barr, Fabien Thaveau, Nabil Chakfe, Bernard Geny, James W. Scholey
    Journal of Molecular and Cellular Cardiology.2016; 91: 11.     CrossRef
  • The Role of the Nrf2/ARE Antioxidant System in Preventing Cardiovascular Diseases
    Robert Smith, Kevin Tran, Cynthia Smith, Miranda McDonald, Pushkar Shejwalkar, Kenji Hara
    Diseases.2016; 4(4): 34.     CrossRef
  • Prohibitin overexpression improves myocardial function in diabetic cardiomyopathy
    Wen-qian Dong, Min Chao, Qing-hua Lu, Wei-li Chai, Wei Zhang, Xue-ying Chen, Er-shun Liang, Ling-bo Wang, Hong-liang Tian, Yu-guo Chen, Ming-xiang Zhang
    Oncotarget.2016; 7(1): 66.     CrossRef
  • Restoration of Nrf2 Signaling Normalizes the Regenerative Niche
    Marc A. Soares, Oriana D. Cohen, Yee Cheng Low, Rita A. Sartor, Trevor Ellison, Utkarsh Anil, Lavinia Anzai, Jessica B. Chang, Pierre B. Saadeh, Piul S. Rabbani, Daniel J. Ceradini
    Diabetes.2016; 65(3): 633.     CrossRef
  • Myocardial transcription factors in diastolic dysfunction: clues for model systems and disease
    Alexander T. Mikhailov, Mario Torrado
    Heart Failure Reviews.2016; 21(6): 783.     CrossRef
  • Antioxidant Properties of Whole Body Periodic Acceleration (pGz)
    Arkady Uryash, Jorge Bassuk, Paul Kurlansky, Francisco Altamirano, Jose R. Lopez, Jose A. Adams, Guillermo López Lluch
    PLOS ONE.2015; 10(7): e0131392.     CrossRef
  • Mulberry leaves (Morus alba L.) ameliorate obesity-induced hepatic lipogenesis, fibrosis, and oxidative stress in high-fat diet-fed mice
    Ji-Young Ann, Hyeyoon Eo, Yunsook Lim
    Genes & Nutrition.2015;[Epub]     CrossRef
  • Oxidative Stress and Human Hypertension: Vascular Mechanisms, Biomarkers, and Novel Therapies
    Augusto C. Montezano, Maria Dulak-Lis, Sofia Tsiropoulou, Adam Harvey, Ana M. Briones, Rhian M. Touyz
    Canadian Journal of Cardiology.2015; 31(5): 631.     CrossRef
  • Haeme oxygenase signalling pathway: implications for cardiovascular disease
    Laura E. Fredenburgh, Allison A. Merz, Susan Cheng
    European Heart Journal.2015; 36(24): 1512.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal
Close layer