Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal

Search
OPEN ACCESS

Author index

Page Path
HOME > Browse > Author index
Search
James D. Johnson 2 Articles
Hyperinsulinemia in Obesity, Inflammation, and Cancer
Anni M.Y. Zhang, Elizabeth A. Wellberg, Janel L. Kopp, James D. Johnson
Diabetes Metab J. 2021;45(4):622-622.   Published online July 30, 2021
DOI: https://doi.org/10.4093/dmj.2021.0131
Corrects: Diabetes Metab J 2021;45(3):285
  • 3,828 View
  • 96 Download
  • 2 Web of Science
  • 10 Crossref
PDFPubReader   ePub   

Citations

Citations to this article as recorded by  
  • Dietary insulin indices and low-carbohydrate diet and the odds of colorectal cancer: a case-control study
    Alireza Bahrami, Karim Parastouei, Maryam Taghdir, Mojtaba Ghadyani
    European Journal of Cancer Prevention.2024; 33(4): 363.     CrossRef
  • Cushing Syndrome Is Associated With a Higher Risk of Cancer—A Nationwide Cohort Study
    Wan-Chen Wu, Jia-Ling Wu, Tien-Shang Huang, Chung-Yi Li, Hung-Yuan Li
    The Journal of Clinical Endocrinology & Metabolism.2024;[Epub]     CrossRef
  • Body‐Wide Inactivation of the Myc‐Like Mlx Transcription Factor Network Accelerates Aging and Increases the Lifetime Cancer Incidence
    Huabo Wang, Taylor Stevens, Jie Lu, Alexander Roberts, Clinton Van't Land, Radhika Muzumdar, Zhenwei Gong, Jerry Vockley, Edward V. Prochownik
    Advanced Science.2024;[Epub]     CrossRef
  • The Interlinking Metabolic Association between Type 2 Diabetes Mellitus and Cancer: Molecular Mechanisms and Therapeutic Insights
    Abutaleb Asiri, Ali Al Qarni, Ahmed Bakillah
    Diagnostics.2024; 14(19): 2132.     CrossRef
  • Non-alcoholic fatty liver disease and diabetes mellitus as growing aetiologies of hepatocellular carcinoma
    Stephanie Talamantes, Michela Lisjak, Eduardo H. Gilglioni, Camilo J. Llamoza-Torres, Bruno Ramos-Molina, Esteban N. Gurzov
    JHEP Reports.2023; : 100811.     CrossRef
  • The impact of poor metabolic health on aggressive breast cancer: adipose tissue and tumor metabolism
    Barbara Mensah Sankofi, Estefania Valencia-Rincón, Malika Sekhri, Adriana L. Ponton-Almodovar, Jamie J. Bernard, Elizabeth A. Wellberg
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Riesgo cardiovascular en adultos: El papel de la Hiperinsulinemia
    María Eugenia Lucena de Ustáriz, Katherine Jazmín Bonilla Adriano, Mónica Gabriela Moncayo Romero, Rosa Elisa Cruz Tenempaguay
    Anatomía Digital.2023; 6(4.3): 777.     CrossRef
  • Obesity history, physical exam, laboratory, body composition, and energy expenditure: An Obesity Medicine Association (OMA) Clinical Practice Statement (CPS) 2022
    Karlijn Burridge, Sandra M. Christensen, Angela Golden, Amy B. Ingersoll, Justin Tondt, Harold E. Bays
    Obesity Pillars.2022; 1: 100007.     CrossRef
  • Special Issue: Emerging Paradigms in Insulin Resistance
    J. Jason Collier, Susan J. Burke
    Biomedicines.2022; 10(7): 1471.     CrossRef
  • Obesity-Associated ECM Remodeling in Cancer Progression
    Junyan Li, Ren Xu
    Cancers.2022; 14(22): 5684.     CrossRef
Pathophysiology
Article image
Hyperinsulinemia in Obesity, Inflammation, and Cancer
Anni M.Y. Zhang, Elizabeth A. Wellberg, Janel L. Kopp, James D. Johnson
Diabetes Metab J. 2021;45(3):285-311.   Published online March 29, 2021
DOI: https://doi.org/10.4093/dmj.2020.0250
Correction in: Diabetes Metab J 2021;45(4):622
  • 29,101 View
  • 996 Download
  • 111 Web of Science
  • 117 Crossref
Graphical AbstractGraphical Abstract AbstractAbstract PDFPubReader   ePub   
The relative insufficiency of insulin secretion and/or insulin action causes diabetes. However, obesity and type 2 diabetes mellitus can be associated with an absolute increase in circulating insulin, a state known as hyperinsulinemia. Studies are beginning to elucidate the cause-effect relationships between hyperinsulinemia and numerous consequences of metabolic dysfunctions. Here, we review recent evidence demonstrating that hyperinsulinemia may play a role in inflammation, aging and development of cancers. In this review, we will focus on the consequences and mechanisms of excess insulin production and action, placing recent findings that have challenged dogma in the context of the existing body of literature. Where relevant, we elaborate on the role of specific signal transduction components in the actions of insulin and consequences of chronic hyperinsulinemia. By discussing the involvement of hyperinsulinemia in various metabolic and other chronic diseases, we may identify more effective therapeutics or lifestyle interventions for preventing or treating obesity, diabetes and cancer. We also seek to identify pertinent questions that are ripe for future investigation.

Citations

Citations to this article as recorded by  
  • High adherence to Western dietary pattern increases breast cancer risk (an EPIC-Spain study)
    Adela Castelló, Miguel Rodríguez-Barranco, Virginia Lope, Marcela Guevara, Sandra Colorado-Yohar, Ane Dorronsoro, José Ramón Quirós, Carlota Castro-Espin, Carmen Sayon-Orea, Carmen Santiuste, Pilar Amiano, Cristina Lasheras, María-José Sanchez, Marina Pol
    Maturitas.2024; 179: 107868.     CrossRef
  • Dietary Diabetes Risk Reduction Score (DDRRS) and Breast Cancer Risk: A Case-Control Study in Iran
    Milad Mohammadzadeh, Alireza Bahrami, Fatemeh Abdi, Fatemeh Ghafouri-Taleghani, Amin Paydareh, Saba Jalali, Zeinab Heidari, Bahram Rashidkhani
    Nutrition and Cancer.2024; 76(1): 106.     CrossRef
  • White adipocyte dysfunction and obesity-associated pathologies in humans
    Carolina E. Hagberg, Kirsty L. Spalding
    Nature Reviews Molecular Cell Biology.2024; 25(4): 270.     CrossRef
  • Cumulative exposure to impaired fasting glucose and gastrointestinal cancer risk: A nationwide cohort study
    Byeong Yun Ahn, Bokyung Kim, Sanghyun Park, Sang Gyun Kim, Kyungdo Han, Soo‐Jeong Cho
    Cancer.2024; 130(10): 1807.     CrossRef
  • Leptin receptor deficiency impedes metabolic surgery related-weight loss through inhibition of energy expenditure in db/db mice
    Dan Tong, Jie Xiang, Wei Liu, Fang Sun, Lijuan Wang, Aidi Mou, Tingbing Cao, Qing Zhou, Mei You, Yingying Liao, Peng Gao, Daoyan Liu, Zongshi Lu, Zhiming Zhu
    Diabetology & Metabolic Syndrome.2024;[Epub]     CrossRef
  • Obesity and Cancer Rehabilitation for Functional Recovery and Quality of Life in Breast Cancer Survivors: A Comprehensive Review
    Lorenzo Lippi, Alessandro de Sire, Arianna Folli, Alessio Turco, Stefano Moalli, Marco Marcasciano, Antonio Ammendolia, Marco Invernizzi
    Cancers.2024; 16(3): 521.     CrossRef
  • Exploring Promising Therapies for Non-Alcoholic Fatty Liver Disease: A ClinicalTrials.gov Analysis
    Omar Hegazi, Samer Alalalmeh, Moyad Shahwan, Ammar Jairoun, Mansour Alourfi, Ghfran Bokhari, Abdullah Alkhattabi, Saeed Alsharif, Mohannad Aljehani, Abdulmalik Alsabban, Mohammad Almtrafi, Ysear Zakri, Abdullah AlMahmoud, Khalid Alghamdi, Ahmed Ashour, Na
    Diabetes, Metabolic Syndrome and Obesity.2024; Volume 17: 545.     CrossRef
  • Predictors of Cardiac Autonomic Dysfunction in Obesity-Related Hypertension
    Aqsa Mujaddadi, Saima Zaki, Majumi M Noohu, Irshad Husain Naqvi, Zubia Veqar
    High Blood Pressure & Cardiovascular Prevention.2024; 31(1): 77.     CrossRef
  • The obesity-autophagy-cancer axis: Mechanistic insights and therapeutic perspectives
    Amir Barzegar Behrooz, Marco Cordani, Alessandra Fiore, Massimo Donadelli, Joseph W. Gordon, Daniel J. Klionsky, Saeid Ghavami
    Seminars in Cancer Biology.2024; 99: 24.     CrossRef
  • Metformin’s role in lowering colorectal cancer risk among individuals with diabetes from the Southern Community Cohort Study
    Thomas Lawler, Zoe L. Walts, Lauren Giurini, Mark Steinwandel, Loren Lipworth, Harvey J. Murff, Wei Zheng, Shaneda Warren Andersen
    Cancer Epidemiology.2024; 90: 102566.     CrossRef
  • Sex differences in insulin regulation of skeletal muscle glycogen synthase and changes during weight loss and exercise in adults
    Alice S. Ryan, Guoyan Li, Shawna McMillin, Heidi K. Ortmeyer
    Obesity.2024; 32(4): 667.     CrossRef
  • Therapeutic Repurposing of Antidiabetic Drugs in Diabetes-associated Comorbidities
    Kalyani Pathak, Manash Pratim Pathak, Riya Saikia, Urvashee Gogoi, Ratna Jyoti Das, Pompy Patowary, Partha Pratim Kaishap, Smita Bordoloi, Jyotirmoy Das, Himangshu Sarma, Mohammad Zaki Ahmad, Aparoop Das
    Current Drug Therapy.2024; 19(2): 178.     CrossRef
  • The effect of metabolic syndrome on prognosis of diffuse large B-cell lymphoma
    Wenjing Xiong, Liru Li, Xue Hui, Yue Liu, Hongbin Li, Yue Zhang, Shu Zhao
    Clinical and Translational Oncology.2024; 26(9): 2240.     CrossRef
  • Impact of Obesity-Related Endoplasmic Reticulum Stress on Cancer and Associated Molecular Targets
    Joud AlBashtawi, Hend Al-Jaber, Sara Ahmed, Layla Al-Mansoori
    Biomedicines.2024; 12(4): 793.     CrossRef
  • Healthcare Management of an Obese Person
    Syeda Rida Baqir, Shafaque Aslam Khan, Bushra Marium Zaman, Tahira Hamid Ali, Nazish Saeed Bangash, Muhammad Amjad Ali, Fatima Zaidi, Jahan Ara Farooq
    DIET FACTOR (Journal of Nutritional and Food Sciences).2024; : 10.     CrossRef
  • Associations between diabetes and cancer: A 10-year national population-based retrospective cohort study
    Heléna Safadi, Ágnes Balogh, Judit Lám, Attila Nagy, Éva Belicza
    Diabetes Research and Clinical Practice.2024; 211: 111665.     CrossRef
  • Association of adipose tissue mediators with the development of cancer in patients with metabolic syndrome
    E. E. Sereda, A. L. Chernyshova, T. Yu. Mamonova, G. V. Kakurina, N. V. Yunusova, E. A. Sidenko, D. A. Korshunov, I. V. Kondakova
    Siberian journal of oncology.2024; 23(2): 101.     CrossRef
  • DIABETES MELLITUS TIPO 2 E OBESIDADE, PRÓGONOS DE NEOPLASIAS?
    Victor Becchi, Luísa Emanoela Bandolin Goinski, Ana Letícia Loesch Wojcik, Patrícia Costa Mincoff Barbanti
    Revista Contemporânea.2024; 4(7): e5071.     CrossRef
  • Therapeutic Insulin Analogue Concentrations at Infusion Sites Enhanced the Pro-Inflammatory Response and Apoptosis in an In Vitro Macrophage-Material Interaction Model
    Yuxi Zhang, Luke Kuo, Kimberly A. Woodhouse, Lindsay E. Fitzpatrick
    ACS Pharmacology & Translational Science.2024; 7(8): 2544.     CrossRef
  • Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease
    Jelena Kolic, WenQing Grace Sun, Haoning Howard Cen, Jessica D. Ewald, Jason C. Rogalski, Shugo Sasaki, Han Sun, Varsha Rajesh, Yi Han Xia, Renata Moravcova, Søs Skovsø, Aliya F. Spigelman, Jocelyn E. Manning Fox, James Lyon, Leanne Beet, Jianguo Xia, Fra
    Cell Metabolism.2024; 36(7): 1619.     CrossRef
  • Aging and “Age-Related” Diseases - What Is the Relation?
    Wolfgang Kopp
    Aging and disease.2024;[Epub]     CrossRef
  • The Complex Connection between Obesity and Cancer: Signaling Pathways and Therapeutic Implications
    Mohamed El-Tanani, Syed Arman Rabbani, Alaa A. Aljabali, Ismail I. Matalka, Yahia El-Tanani, Manfredi Rizzo, Murtaza M. Tambuwala
    Nutrition and Cancer.2024; 76(8): 683.     CrossRef
  • Gut microbiota and fecal volatilome profile inspection in metabolically healthy and unhealthy obesity phenotypes
    F. M. Calabrese, V. A. Genchi, N. Serale, G. Celano, M. Vacca, G. Palma, M. Svelto, L. Gesualdo, M. De Angelis, F. Giorgino, S. Perrini
    Journal of Endocrinological Investigation.2024;[Epub]     CrossRef
  • Targeting SIRT3 signaling alleviates lung carcinoma progression by reducing hyperinsulinemia in postmenopausal obese mice: Protective intervention of betaxanthin
    Bobo Li, Jie Liu, Yuhui Sun, Mengmeng Song, Xiaoming Zhao, Yulan Sun
    Journal of Functional Foods.2024; 119: 106313.     CrossRef
  • Mechanisms Underlying the Rarity of Skeletal Muscle Cancers
    David S. Kump
    International Journal of Molecular Sciences.2024; 25(12): 6480.     CrossRef
  • Unbiasedly decoding the tumor microenvironment with single-cell multiomics analysis in pancreatic cancer
    Yifan Fu, Jinxin Tao, Tao Liu, Yueze Liu, Jiangdong Qiu, Dan Su, Ruobing Wang, Wenhao Luo, Zhe Cao, Guihu Weng, Taiping Zhang, Yupei Zhao
    Molecular Cancer.2024;[Epub]     CrossRef
  • Beta-Hydroxybutyrate Promotes Basal Insulin Secretion While Decreasing Glucagon Secretion in Mouse and Human Islets
    Risha Banerjee, Ying Zhu, George P Brownrigg, Renata Moravcova, Jason C Rogalski, Leonard J Foster, James D Johnson, Jelena Kolic
    Endocrinology.2024;[Epub]     CrossRef
  • Oligomalt, a New Slowly Digestible Carbohydrate, Reduces Post-Prandial Glucose and Insulin Trajectories Compared to Maltodextrin across Different Population Characteristics: Double-Blind Randomized Controlled Trials in Healthy Individuals, People with Obe
    Odd Erik Johansen, Joel Neutel, Sanjay Gupta, Barbara Mariani, Gerhard Ufheil, Emilie Perrin, Andreas Rytz, Anirban Lahiry, Frederik Delodder, Jaclyn Lerea-Antes, Naomi Ocampo, Maximilian von Eynatten
    Metabolites.2024; 14(8): 410.     CrossRef
  • Forkhead box protein FOXK1 disrupts the circadian rhythm to promote breast tumorigenesis in response to insulin resistance
    Zhaohan Zhang, Minghui Zhao, Qian Wang, Xilin Wang, Yu Wang, Yuze Ge, Zicheng Wu, Wenjuan Wang, Lin Shan
    Cancer Letters.2024; 599: 217147.     CrossRef
  • Protein Arginine Methyltransferases: Emerging Targets in Cardiovascular and Metabolic Disease
    Yan Zhang, Shibo Wei, Eun-Ju Jin, Yunju Jo, Chang-Myung Oh, Gyu-Un Bae, Jong-Sun Kang, Dongryeol Ryu
    Diabetes & Metabolism Journal.2024; 48(4): 487.     CrossRef
  • Body Mass Index and Metabolic Phenotypes in Breast Cancer Risk: A Meta-Analysis and Systematic Review
    Víctor Juan Vera-Ponce, Joan A. Loayza-Castro, Luisa Erika Milagros Vásquez-Romero, Fiorella Elvira Zuzunaga-Montoya
    International Journal of Statistics in Medical Research.2024; 13: 107.     CrossRef
  • The Association Between Telomere Length and Diabetes Mellitus: Accumulated Evidence From Observational Studies
    Xinxin He, Lu Cao, Xueru Fu, Yuying Wu, Hongwei Wen, Yajuan Gao, Weifeng Huo, Mengdi Wang, Mengna Liu, Yijia Su, Ge Liu, Ming Zhang, Fulan Hu, Dongsheng Hu, Yang Zhao
    The Journal of Clinical Endocrinology & Metabolism.2024;[Epub]     CrossRef
  • Metabolic dysfunction-associated steatotic liver disease and its link to cancer
    Markos Kalligeros, Linda Henry, Zobair M. Younossi
    Metabolism.2024; 160: 156004.     CrossRef
  • Uncovering the Links Between Dietary Sugar and Cancer: A Narrative Review Exploring the Impact of Dietary Sugar and Fasting on Cancer Risk and Prevention
    Ashik Anil , Ronak Raheja, Diya Gibu, Aravind S Raj, S Spurthi
    Cureus.2024;[Epub]     CrossRef
  • Carbohydrate quality indices and lung cancer risk: a case–control study from Iran
    Milad Mohammadzadeh, Fatemeh Abdi, Melika Mamaghanian, Amin Paydareh, Alireza Bahrami, Zahra Sheikhi, Ehsan Hejazi
    European Journal of Cancer Prevention.2024;[Epub]     CrossRef
  • Effects of T2DM on cancer progression: pivotal precipitating factors and underlying mechanisms
    Yu-Yuan Zhang, Yong-Jiang Li, Chun-Dong Xue, Shen Li, Zheng-Nan Gao, Kai-Rong Qin
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • Associations between different insulin resistance indices and the risk of all-cause mortality in peritoneal dialysis patients
    Guowen Zhao, Sijia Shang, Na Tian, Xiaojiang Zhan, Fenfen Peng, Xiaoyang Wang, Yueqiang Wen, Qingdong Xu, Xiaoran Feng, Xingming Tang, Xianfeng Wu, Qian Zhou, Yuanyuan Yang, Xing Zhang, Ning Su
    Lipids in Health and Disease.2024;[Epub]     CrossRef
  • Relationship between the Mediterranean Diet and Vascular Function in Subjects with and without Increased Insulin Resistance
    Marta Gómez-Sánchez, Leticia Gómez-Sánchez, Rocío Llamas-Ramos, Emiliano Rodríguez-Sánchez, Luis García-Ortiz, Ruth Martí-Lluch, María Cortés Rodríguez, Inés Llamas-Ramos, Manuel A. Gómez-Marcos
    Nutrients.2024; 16(18): 3106.     CrossRef
  • Influence of Type 2 Diabetes and Adipose Tissue Dysfunction on Breast Cancer and Potential Benefits from Nutraceuticals Inducible in Microalgae
    Domenico Sergi, Mattia Melloni, Angelina Passaro, Luca Maria Neri
    Nutrients.2024; 16(19): 3243.     CrossRef
  • Intestinal ABC transporters: Influence on the metronomic cyclophosphamide-induced toxic effect in an obese mouse mammary cancer model
    María Manuela Barranco, Felipe Zecchinati, Virginia Gabriela Perdomo, Martín José Habib, María José Rico, Viviana Rosa Rozados, Mario Salazar, Matías Ezequiel Fusini, Olga Graciela Scharovsky, Silvina Stella Maris Villanueva, Leandro Ernesto Mainetti, Fab
    Toxicology and Applied Pharmacology.2024; 492: 117130.     CrossRef
  • Association between different patterns of obesity and the short-term outcomes of gastric cancer surgery
    Guoqing Shi, Tianyu Gao, Peng Du, Jiwu Guo, Yan Dong, Jie Mao
    European Journal of Cancer Prevention.2024;[Epub]     CrossRef
  • Association Between Physical Activity and Pancreatic Cancer Risk and Mortality: A Systematic Review and Meta-Analysis
    Mylena D. Bos, Jelmer E. Oor, Lucas Goense, N. Helge Meyer, Maximilian Bockhorn, Frederik J. H. Hoogwater, Joost M. Klaase, Maarten W. Nijkamp
    Cancers.2024; 16(21): 3594.     CrossRef
  • The risk of cancer among insulin glargine users in Lithuania: A retrospective population-based study
    Justinas Jonusas, Mingailė Drevinskaitė, Donata Linkeviciute-Ulinskiene, Adomas Ladukas, Aušvydas Patašius, Lina Zabulienė, Giedrė Smailytė
    Open Medicine.2024;[Epub]     CrossRef
  • Risk Factors for Early Post-transplant Weight Changes Among Simultaneous Pancreas-kidney Recipients and Impact on Outcomes
    Sandesh Parajuli, Riccardo Tamburrini, Fahad Aziz, Ban Dodin, Brad C. Astor, Didier Mandelbrot, Dixon Kaufman, Jon Odorico
    Transplantation Direct.2024; 10(11): e1720.     CrossRef
  • Transitions in metabolic syndrome and metabolic obesity status over time and risk of urologic cancer: A prospective cohort study
    Xia Wang, Runxue Jiang, Jianglun Shen, Shuohua Chen, Shouling Wu, Hailong Hu, Haifeng Cai, Yuki Arita
    PLOS ONE.2024; 19(10): e0311492.     CrossRef
  • Advances in “adiponcosis”: Insights in the inner mechanisms at the base of adipose and tumour tissues interplay
    Cristina Pagano, Erika di Zazzo, Giorgio Avilia, Beatrice Savarese, Giovanna Navarra, Maria Chiara Proto, Donatella Fiore, Monica Rienzo, Patrizia Gazzerro, Chiara Laezza, Maurizio Bifulco
    International Journal of Cancer.2023; 152(12): 2464.     CrossRef
  • Influence of antidiabetic drugs on glucose metabolism and immune response in patients with metastatic pancreatic ductal adenocarcinoma receiving gemcitabine plus nab-paclitaxel as first-line treatment
    Andrea Pretta, Pina Ziranu, Riccardo Giampieri, Clelia Donisi, Erika Cimbro, Dario Spanu, Eleonora Lai, Federica Pecci, Francesca Balconi, Alessio Lupi, Marta Pozzari, Mara Persano, Sara Murgia, Valeria Pusceddu, Marco Puzzoni, Rossana Berardi, Mario Scar
    Digestive and Liver Disease.2023; 55(5): 655.     CrossRef
  • Islet amyloid polypeptide does not suppress pancreatic cancer
    Austin J. Taylor, Evgeniy Panzhinskiy, Paul C. Orban, Francis C. Lynn, David F. Schaeffer, James D. Johnson, Janel L. Kopp, C. Bruce Verchere
    Molecular Metabolism.2023; 68: 101667.     CrossRef
  • Pathophysiology of obesity and its associated diseases
    Xin Jin, Tingting Qiu, Li Li, Rilei Yu, Xiguang Chen, Changgui Li, Christopher G. Proud, Tao Jiang
    Acta Pharmaceutica Sinica B.2023; 13(6): 2403.     CrossRef
  • Metabolic syndrome as a risk factor for oncogenesis
    M.A. Osadchuk, I.N. Vasilieva, V.V. Kozlov, O.I. Mitrokhina
    Profilakticheskaya meditsina.2023; 26(1): 70.     CrossRef
  • Polycystic ovary syndrome: Causes, symptoms, pathophysiology, and remedies
    Ananya Chaudhuri
    Obesity Medicine.2023; 39: 100480.     CrossRef
  • Metformin and long non-coding RNAs in breast cancer
    Morteza Gholami, Zeynab Nickhah Klashami, Pirooz Ebrahimi, Amir Ali Mahboobipour, Amir Salehi Farid, Aida Vahidi, Marziyeh Zoughi, Mojgan Asadi, Mahsa M. Amoli
    Journal of Translational Medicine.2023;[Epub]     CrossRef
  • Host-Related Factors in the Interplay among Inflammation, Immunity and Dormancy in Breast Cancer Recurrence and Prognosis: An Overview for Clinicians
    Lorenzo Ruggieri, Anna Moretti, Rossana Berardi, Maria Silvia Cona, Davide Dalu, Cecilia Villa, Davide Chizzoniti, Sheila Piva, Anna Gambaro, Nicla La Verde
    International Journal of Molecular Sciences.2023; 24(5): 4974.     CrossRef
  • Degree of obesity and gastrointestinal adverse reactions influence the weight loss effect of liraglutide in overweight or obese patients with type 2 diabetes
    Fang Zhou, Lu Jiang, Jiamei Guo, Yuting Fan, Qin Pan, Tianlian Li, Xiaoshi Sun, Ping Li
    Therapeutic Advances in Chronic Disease.2023;[Epub]     CrossRef
  • Both early and late maternal age at childbirth is associated with increasing odds of central obesity in offspring
    Hongyun Chen, Yinhua Feng, Changying Chen, Songcheng Yu
    American Journal of Human Biology.2023;[Epub]     CrossRef
  • Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings
    Teresa L. Mastracci, Minoti Apte, Laufey T. Amundadottir, Alexandra Alvarsson, Steven Artandi, Melena D. Bellin, Ernesto Bernal-Mizrachi, Alejandro Caicedo, Martha Campbell-Thompson, Zobeida Cruz-Monserrate, Abdelfattah El Ouaamari, Kyle J. Gaulton, Andre
    Diabetes.2023; 72(4): 433.     CrossRef
  • Obesity-induced changes in cancer cells and their microenvironment: Mechanisms and therapeutic perspectives to manage dysregulated lipid metabolism
    Miriam Lee-Rueckert, Marina Canyelles, Mireia Tondo, Noemi Rotllan, Petri T. Kovanen, Vicenta Llorente-Cortes, Joan Carles Escolà-Gil
    Seminars in Cancer Biology.2023; 93: 36.     CrossRef
  • PIK3CA mutation in endometriotic epithelial cells promotes viperin-dependent inflammatory response to insulin
    Mike R. Wilson, Shannon Harkins, Jake J. Reske, Rebecca A. Siwicki, Marie Adams, Victoria L. Bae-Jump, Jose M. Teixeira, Ronald L. Chandler
    Reproductive Biology and Endocrinology.2023;[Epub]     CrossRef
  • Gut microbiome modified by bariatric surgery improves insulin sensitivity and correlates with increased brown fat activity and energy expenditure
    Jitender Yadav, Tao Liang, Tairan Qin, Nayanan Nathan, Katherine J.P. Schwenger, Lauren Pickel, Li Xie, Helena Lei, Daniel A. Winer, Heather Maughan, Susan J. Robertson, Minna Woo, Wendy Lou, Kate Banks, Timothy Jackson, Allan Okrainec, Susy S. Hota, Susa
    Cell Reports Medicine.2023; 4(5): 101051.     CrossRef
  • Prevalence of Type 2 Diabetes, Impaired Fasting Glucose, and Diabetes Risk in an Adult and Older North-Eastern Portuguese Population
    Pedro M. Magalhães, José E. Teixeira, João P. Bragada, Carlos M. Duarte, José A. Bragada
    Healthcare.2023; 11(12): 1712.     CrossRef
  • Hyperinsulinemia Influences the Short-Term Efficiency of Laparoscopic Sleeve Gastrectomy for Patients with Obesity and Insulin Resistance
    Zilong Yue, Long Qian, Yan Jin, Yabin Xia, Hui Sha, Qin Wu, Kaifeng Hu
    Diabetes, Metabolic Syndrome and Obesity.2023; Volume 16: 1745.     CrossRef
  • Acetyl-11-Keto-Beta-Boswellic Acid Has Therapeutic Benefits for NAFLD Rat Models That Were Given a High Fructose Diet by Ameliorating Hepatic Inflammation and Lipid Metabolism
    Reza Ataei Kachouei, Alireza Doagoo, Maral Jalilzadeh, Seyyed Hossein Khatami, Shima Rajaei, Ali Jahanbazi Jahan-Abad, Farzaneh Salmani, Roya Pakrad, Somayeh Mahmoodi Baram, Mitra Nourbakhsh, Mohammad-Amin Abdollahifar, Hojjat Allah Abbaszadeh, Shokoofeh
    Inflammation.2023; 46(5): 1966.     CrossRef
  • Cancer Risk and its Association With Diabetes Mellitus in Patients With Acromegaly: A Two Center-based Study
    Zhe-Hao Xiao, Cheng Wang, Yong Wang, Shang-Kun Yuan, Cheng Huang, Ren-Fang Chen, Yong Li
    Endocrine Practice.2023; 29(9): 699.     CrossRef
  • Obesity, diabetes, and cancer: epidemiology, pathophysiology, and potential interventions
    Leonardo de Andrade Mesquita, Laura Fink Wayerbacher, Gilberto Schwartsmann, Fernando Gerchman
    Archives of Endocrinology and Metabolism.2023;[Epub]     CrossRef
  • Insulin Stimulates IL-23 Expression in Human Adipocytes: A Possible Explanation for the Higher Prevalence of Psoriasis in Obesity
    Angelo Di Vincenzo, Marnie Granzotto, Marika Crescenzi, Camilla Costa, Stefano Piaserico, Vincenzo Vindigni, Roberto Vettor, Marco Rossato
    Diabetes, Metabolic Syndrome and Obesity.2023; Volume 16: 1885.     CrossRef
  • Immunometabolic aspects of chronic nonspecific inflammation in obesity
    O. V. Skvortsova, N. B. Migacheva, E. G. Mikhailova
    Meditsinskiy sovet = Medical Council.2023; (12): 75.     CrossRef
  • The Reponic Classification of Insulin
    Joshua Moen
    Canadian Journal of Diabetes.2023; 47(8): 680.     CrossRef
  • Dietary Acid Load and Cancer Risk: A Review of the Uruguayan Experience
    Alvaro Luis Ronco, Maximilian Andreas Storz
    Nutrients.2023; 15(14): 3098.     CrossRef
  • Non-alcoholic fatty liver disease and diabetes mellitus as growing aetiologies of hepatocellular carcinoma
    Stephanie Talamantes, Michela Lisjak, Eduardo H. Gilglioni, Camilo J. Llamoza-Torres, Bruno Ramos-Molina, Esteban N. Gurzov
    JHEP Reports.2023; 5(9): 100811.     CrossRef
  • Alteration of Metabolic Syndrome Is Associated with the Decreased Risk of Colorectal Cancer
    Eun Hyo Jin, Yoon Jin Choi, Joo Hyun Lim, Cheol Min Shin, Kyungdo Han, Dong Ho Lee
    Journal of Clinical Medicine.2023; 12(15): 4889.     CrossRef
  • Dietary interventions improve diabetic kidney disease, but not peripheral neuropathy, in a db/db mouse model of type 2 diabetes
    Stephanie A. Eid, Phillipe D. O'Brien, Katharina H. Kretzler, Dae‐Gyu Jang, Faye E. Mendelson, John M. Hayes, Andrew Carter, Hongyu Zhang, Subramaniam Pennathur, Frank C. Brosius, Emily J. Koubek, Eva L. Feldman
    The FASEB Journal.2023;[Epub]     CrossRef
  • Decoding the role of leptin and adiponectin in obesity-related gastrointestinal cancer
    Vanda Marques, Fabiola Arella, Marta B. Afonso, André A. Santos, Cecília M.P. Rodrigues
    Clinical Science.2023; 137(15): 1095.     CrossRef
  • Metformin Can Attenuate Beta-Cell Hypersecretion—Implications for Treatment of Children with Obesity
    Quan Wen, Rasmus Stenlid, Azazul Islam Chowdhury, Iris Ciba, Banu Aydin, Sara Y. Cerenius, Hannes Manell, Anders Forslund, Peter Bergsten
    Metabolites.2023; 13(8): 917.     CrossRef
  • The Effectiveness of a Low Glycemic Index/Load Diet on Cardiometabolic, Glucometabolic, and Anthropometric Indices in Children with Overweight or Obesity: A Systematic Review and Meta-Analysis
    Ioustini Kalaitzopoulou, Xenophon Theodoridis, Evangelia Kotzakioulafi, Kleo Evripidou, Michail Chourdakis
    Children.2023; 10(9): 1481.     CrossRef
  • A review of the last decade: pancreatic cancer and type 2 diabetes
    Jiaqi Wu, Liang Tang, Feng Zheng, Xun Chen, Lei Li
    Archives of Physiology and Biochemistry.2023; : 1.     CrossRef
  • Characteristics of Children and Adolescents with Hyperinsulinemia Undergoing Oral Glucose Tolerance Test: A Single-Center Retrospective Observational Study
    Clelia Cipolla, Ilaria Lazzareschi, Antonietta Curatola, Claudia Lasorella, Lucia Celeste Pane, Linda Sessa, Giulia Rotunno, Donato Rigante, Giorgio Sodero
    Diseases.2023; 11(3): 110.     CrossRef
  • Hyperinsulinemia acts via acinar insulin receptors to initiate pancreatic cancer by increasing digestive enzyme production and inflammation
    Anni M.Y. Zhang, Yi Han Xia, Jeffrey S.H. Lin, Ken H. Chu, Wei Chuan K. Wang, Titine J.J. Ruiter, Jenny C.C. Yang, Nan Chen, Justin Chhuor, Shilpa Patil, Haoning Howard Cen, Elizabeth J. Rideout, Vincent R. Richard, David F. Schaeffer, Rene P. Zahedi, Chr
    Cell Metabolism.2023; 35(12): 2119.     CrossRef
  • Dairy Intake Modifies the Level of the Bile Acid Precursor and Its Correlation with Serum Proteins Associated with Cholesterol Clearance in Subjects with Hyperinsulinemia
    Atena Mahdavi, Jocelyn Trottier, Olivier Barbier, Michel Lebel, Iwona Rudkowska
    Nutrients.2023; 15(22): 4707.     CrossRef
  • Trapa Bispinosa Roxb. Inhibits the Insulin-Dependent AKT/WNK1 Pathway to Induce Autophagy in Mice with Type 2 Diabetes
    Takahiro Suzuki, Takehito Sato, Kaori Masuhara, Mizuki Tokusanai, Hisako Akatsuka, Tomohiro Kashikawa, Yasuyuki Suzuki
    Diabetes, Metabolic Syndrome and Obesity.2023; Volume 16: 3095.     CrossRef
  • Effects of Functional and Nutraceutical Foods in the Context of the Mediterranean Diet in Patients Diagnosed with Breast Cancer
    Giovanna Flore, Andrea Deledda, Mauro Lombardo, Andrea Armani, Fernanda Velluzzi
    Antioxidants.2023; 12(10): 1845.     CrossRef
  • A systematic review exploring the mechanisms by which citrus bioflavonoid supplementation benefits blood glucose levels and metabolic complications in type 2 diabetes mellitus
    Ankit Gupta, Abdulsatar Jamal, Dina A. Jamil, Hayder A. Al-Aubaidy
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2023; 17(11): 102884.     CrossRef
  • Diabetes Mellitus and Gastric Cancer: Correlation and Potential Mechanisms
    Li Wang, Zhe Zhang, Eusebio Chiefari
    Journal of Diabetes Research.2023; 2023: 1.     CrossRef
  • EXPLORATORY ANALYSIS OF DIETARY PATTERNS OF PATIENTS WITH GASTRIC ADENOCARCINOMA: A CASE-CONTROL STUDY IN CENTRAL BRAZIL
    Silvana Barbosa SANTIAGO, Gabriela Rodrigues de SOUSA, Amanda Ferreira Paes Landim RAMOS, Gisele Aparecida FERNANDES, Maria Paula CURADO, Mônica Santiago BARBOSA
    Arquivos de Gastroenterologia.2023; 60(4): 419.     CrossRef
  • Risk of cancer in acromegaly patients: An updated meta-analysis and systematic review
    Zhehao Xiao, Pingping Xiao, Yong Wang, Chen Fang, Yong Li, Alvaro Galli
    PLOS ONE.2023; 18(11): e0285335.     CrossRef
  • Long Follow-Up Times Weaken Observational Diet–Cancer Study Outcomes: Evidence from Studies of Meat and Cancer Risk
    William B. Grant
    Nutrients.2023; 16(1): 26.     CrossRef
  • Serum Lipid Profiles and Cholesterol-Lowering Medication Use in Relation to Subsequent Risk of Colorectal Cancer in the UK Biobank Cohort
    Fangcheng Yuan, Wanqing Wen, Guochong Jia, Jirong Long, Xiao-Ou Shu, Wei Zheng
    Cancer Epidemiology, Biomarkers & Prevention.2023; 32(4): 524.     CrossRef
  • Exploring the role of hyperinsulinemia in obesity-associated tumor development
    Ericka Vélez-Bonet, Kristyn Gumpper-Fedus, Zobeida Cruz-Monserrate
    Cancer Research.2023;[Epub]     CrossRef
  • Prevalence of diabetes mellitus among 80,193 gastrointestinal cancer patients in five European and three Asian countries
    Christoph Roderburg, Sven H. Loosen, Laura Hoyer, Tom Luedde, Karel Kostev
    Journal of Cancer Research and Clinical Oncology.2022; 148(5): 1057.     CrossRef
  • The Intricate Crosstalk Between Insulin and Pancreatic Ductal Adenocarcinoma: A Review From Clinical to Molecular
    Junyuan Deng, Yujie Guo, Jiali Du, Jichun Gu, Lei Kong, Boan Tao, Ji Li, Deliang Fu
    Frontiers in Cell and Developmental Biology.2022;[Epub]     CrossRef
  • Effects of hyperinsulinemia on pancreatic cancer development and the immune microenvironment revealed through single-cell transcriptomics
    Anni M. Y. Zhang, Ken H. Chu, Brian F. Daly, Titine Ruiter, Yan Dou, Jenny C. C. Yang, Twan J. J. de Winter, Justin Chhuor, Su Wang, Stephane Flibotte, Yiwei Bernie Zhao, Xiaoke Hu, Hong Li, Elizabeth J. Rideout, David F. Schaeffer, James D. Johnson, Jane
    Cancer & Metabolism.2022;[Epub]     CrossRef
  • Ghrelin and Cancer: Examining the Roles of the Ghrelin Axis in Tumor Growth and Progression
    Anuhya S. Kotta, Abigail S. Kelling, Karen A. Corleto, Yuxiang Sun, Erin D. Giles
    Biomolecules.2022; 12(4): 483.     CrossRef
  • Influence of obesity on reproductive health before andduring pregnancy
    A. Konwisser, O. Korytko
    INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine).2022; 18(8): 446.     CrossRef
  • Research Status of the Correlation between Type 2 Diabetes Mellitus and the Occurrence and Development of Breast Cancer
    聪 李
    Advances in Clinical Medicine.2022; 12(04): 3010.     CrossRef
  • Effect of Carbohydrate-Restricted Diets and Intermittent Fasting on Obesity, Type 2 Diabetes Mellitus, and Hypertension Management: Consensus Statement of the Korean Society for the Study of Obesity, Korean Diabetes Association, and Korean Society of Hype
    Jong Han Choi, Yoon Jeong Cho, Hyun-Jin Kim, Seung-Hyun Ko, Suk Chon, Jee-Hyun Kang, Kyoung-Kon Kim, Eun Mi Kim, Hyun Jung Kim, Kee-Ho Song, Ga Eun Nam, Kwang Il Kim
    Diabetes & Metabolism Journal.2022; 46(3): 355.     CrossRef
  • Obesity and Pancreatic Cancer: Recent Progress in Epidemiology, Mechanisms and Bariatric Surgery
    Shuhei Shinoda, Naohiko Nakamura, Brett Roach, David A. Bernlohr, Sayeed Ikramuddin, Masato Yamamoto
    Biomedicines.2022; 10(6): 1284.     CrossRef
  • Effect of carbohydrate-restricted diets and intermittent fasting on obesity, type 2 diabetes mellitus, and hypertension management: consensus statement of the Korean Society for the Study of obesity, Korean Diabetes Association, and Korean Society of Hype
    Jong Han Choi, Yoon Jeong Cho, Hyun-Jin Kim, Seung-Hyun Ko, Suk Chon, Jee-Hyun Kang, Kyoung-Kon Kim, Eun Mi Kim, Hyun Jung Kim, Kee-Ho Song, Ga Eun Nam, Kwang Il Kim
    Clinical Hypertension.2022;[Epub]     CrossRef
  • Vitamin D and Risk of Obesity-Related Cancers: Results from the SUN (‘Seguimiento Universidad de Navarra’) Project
    Rodrigo Sánchez-Bayona, Maira Bes-Rastrollo, Cesar I. Fernández-Lázaro, Maite Bastyr, Ainhoa Madariaga, Juan J. Pons, Miguel A. Martínez-González, Estefanía Toledo
    Nutrients.2022; 14(13): 2561.     CrossRef
  • Metabolically Defined Body Size Phenotypes and Risk of Endometrial Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)
    Nathalie Kliemann, Romain Ould Ammar, Carine Biessy, Audrey Gicquiau, Verena Katzke, Rudolf Kaaks, Anne Tjønneland, Anja Olsen, Maria-Jose Sánchez, Marta Crous-Bou, Fabrizio Pasanisi, Sandar Tin Tin, Aurora Perez-Cornago, Dagfinn Aune, Sofia Christakoudi,
    Cancer Epidemiology, Biomarkers & Prevention.2022; 31(7): 1359.     CrossRef
  • Effect of Carbohydrate-Restricted Diets and Intermittent Fasting on Obesity, Type 2 Diabetes Mellitus, and Hypertension Management: Consensus Statement of the Korean Society for the Study of Obesity, Korean Diabetes Association, and Korean Society of Hype
    Jong Han Choi, Yoon Jeong Cho, Hyun-Jin Kim, Seung-Hyun Ko, Suk Chon, Jee-Hyun Kang, Kyoung-Kon Kim, Eun Mi Kim, Hyun Jung Kim, Kee-Ho Song, Ga Eun Nam, Kwang Il Kim
    Journal of Obesity & Metabolic Syndrome.2022; 31(2): 100.     CrossRef
  • Detangling the interrelations between MAFLD, insulin resistance, and key hormones
    Shreya C. Pal, Mohammed Eslam, Nahum Mendez-Sanchez
    Hormones.2022; 21(4): 573.     CrossRef
  • Obesity, cancer risk, and time-restricted eating
    Manasi Das, Nicholas J. G. Webster
    Cancer and Metastasis Reviews.2022; 41(3): 697.     CrossRef
  • Associations between early-life growth pattern and body size and follicular lymphoma risk and survival: a family-based case-control study
    Michael K. Odutola, Marina T. van Leeuwen, Jennifer Turner, Fiona Bruinsma, John F. Seymour, H. Miles Prince, Samuel T. Milliken, Mark Hertzberg, Judith Trotman, Stephen S. Opat, Robert Lindeman, Fernando Roncolato, Emma Verner, Michael Harvey, Campbell T
    Cancer Epidemiology.2022; 80: 102241.     CrossRef
  • Differential expression of Ago2‐mediated microRNA signaling in adipose tissue is associated with food‐induced obesity
    Hansi Zhang, Liang Qiao, Xiaoxuan Liu, Xiaojing Han, Jing Kang, Yanli Liu, Juntang Lin, Xin Yan
    FEBS Open Bio.2022; 12(10): 1828.     CrossRef
  • Proposal for standardizing normal insulin ranges in Brazilian patients and a new classification of metabolic syndrome
    Pedro Renato Chocair, Precil Diego Miranda de Menezes Neves, Victor Augusto Hamamoto Sato, Sara Mohrbacher, Érico Souza Oliveira, Leonardo Victor Barbosa Pereira, Alessandra Martins Bales, Fagner Pereira da Silva, John A. Duley, Américo Lourenço Cuvello-N
    Frontiers in Medicine.2022;[Epub]     CrossRef
  • Two models of insulin resistance development and the strategy to combat age-related diseases: literature review
    A. V. Martyushev-Poklad, D. S. Yankevich, M. V. Petrova, N. G. Savitskaya
    Problems of Endocrinology.2022; 68(4): 59.     CrossRef
  • In Vitro Mimicking of Obesity-Induced Biochemical Environment to Study Obesity Impacts on Cells and Tissues
    Abdelaziz Ghanemi, Mayumi Yoshioka, Jonny St-Amand
    Diseases.2022; 10(4): 76.     CrossRef
  • Long‐term survival analysis of patients with stage IIIB‐IV non‐small cell lung cancer complicated by type 2 diabetes mellitus: A retrospective propensity score matching analysis
    Xuejiao Li, Haiyan Fang, Dongwei Zhang, Liming Xia, Xiang Wang, Jingping Yang, Shaohu Zhang, Ya Su, Yongfu Zhu
    Thoracic Cancer.2022; 13(23): 3268.     CrossRef
  • Diabetes and skin cancers: Risk factors, molecular mechanisms and impact on prognosis
    Elena-Codruta Dobrică, Madalina Laura Banciu, Vincent Kipkorir, Mohammad Amin Khazeei Tabari, Madeleine Jemima Cox, L V Simhachalam Kutikuppala, Mihnea-Alexandru Găman
    World Journal of Clinical Cases.2022; 10(31): 11214.     CrossRef
  • The role of the mTOR pathway in diabetic retinopathy
    Fabio Casciano, Enrico Zauli, Erika Rimondi, Marco Mura, Maurizio Previati, Massimo Busin, Giorgio Zauli
    Frontiers in Medicine.2022;[Epub]     CrossRef
  • Hyperinsulinemia-induced microglial mitochondrial dynamic and metabolic alterations lead to neuroinflammation in vivo and in vitro
    Xiaohan Yang, Yuan Xu, Wenting Gao, Li Wang, Xinnan Zhao, Gang Liu, Kai Fan, Shuang Liu, Huimin Hao, Siyan Qu, Renhou Dong, Xiaokai Ma, Jianmei Ma
    Frontiers in Neuroscience.2022;[Epub]     CrossRef
  • Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases
    Teresa L. Mastracci, Minoti Apte, Laufey T. Amundadottir, Alexandra Alvarsson, Steven Artandi, Melena D. Bellin, Ernesto Bernal-Mizrachi, Alejandro Caicedo, Martha Campbell-Thompson, Zobeida Cruz-Monserrate, Abdelfattah El Ouaamari, Kyle J. Gaulton, Andre
    Pancreas.2022; 51(9): 1061.     CrossRef
  • Intestinal Microbiome Modified by Bariatric Surgery Improves Insulin Sensitivity and Correlates with Increased Brown Fat Activity and Energy Expenditure
    jitender Yadav, Tao Liang, Tairan Qin, Nayanan N. Nathan, Katherine J.P Schwenger, Lauren Pickel, Li Xie, Helena Lei, Daniel A. Winer, Heather Maughan, Susan J. Robertson, Minna Woo, Wendy Y. W. Lou, Kate Banks, Timothy Jackson, Allan Okrainec, Susy S. Ho
    SSRN Electronic Journal .2022;[Epub]     CrossRef
  • Severe hyperglycemia and insulin resistance in patients with SARS-CoV-2 infection: a report of two cases
    Alison H. Affinati, Amisha Wallia, Roma Y. Gianchandani
    Clinical Diabetes and Endocrinology.2021;[Epub]     CrossRef
  • Promises and pitfalls of beta cell–replacement therapies
    Jelena Kolic, James D. Johnson
    Nature Metabolism.2021; 3(8): 1036.     CrossRef
  • Hiding unhealthy heart outcomes in a low-fat diet trial: the Women’s Health Initiative Randomized Controlled Dietary Modification Trial finds that postmenopausal women with established coronary heart disease were at increased risk of an adverse outcome if
    Timothy David Noakes
    Open Heart.2021; 8(2): e001680.     CrossRef
  • On the causal relationships between hyperinsulinaemia, insulin resistance, obesity and dysglycaemia in type 2 diabetes
    James D. Johnson
    Diabetologia.2021; 64(10): 2138.     CrossRef
  • Diabetes mellitus and cancer: a system of insulin-like growth factors
    E. M. Frantsiyants, E. I. Surikova, I. V. Kaplieva, V. A. Bandovkina, I. V. Neskubina, E. A. Sheiko, M. I. Morozova, I. M. Kotieva
    Problems of Endocrinology.2021; 67(5): 34.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal
Close layer
TOP