- Obesity and Metabolic Syndrome
- The Protective Effects of Increasing Serum Uric Acid Level on Development of Metabolic Syndrome
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Tae Yang Yu, Sang-Man Jin, Jae Hwan Jee, Ji Cheol Bae, Moon-Kyu Lee, Jae Hyeon Kim
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Diabetes Metab J. 2019;43(4):504-520. Published online February 21, 2019
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DOI: https://doi.org/10.4093/dmj.2018.0079
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- Background
It has not been determined whether changes in serum uric acid (SUA) level are associated with incident metabolic syndrome (MetS). The aim of the current study was to investigate the relationship between changes in SUA level and development of MetS in a large number of subjects. MethodsIn total, 13,057 subjects participating in a medical health check-up program without a diagnosis of MetS at baseline were enrolled. Cox proportional hazards models were used to test the independent association of percent changes in SUA level with development of MetS. ResultsAfter adjustment for age, systolic blood pressure, body mass index, fat-free mass (%), estimated glomerular filtration rate, smoking status, fasting glucose, triglyceride, low density lipoprotein cholesterol, high density lipoprotein cholesterol, and baseline SUA levels, the hazard ratios (HRs) (95% confidence intervals [CIs]) for incident MetS in the second, third, and fourth quartiles compared to the first quartile of percent change in SUA level were 1.055 (0.936 to 1.190), 0.927 (0.818 to 1.050), and 0.807 (0.707 to 0.922) in male (P for trend <0.001) and 1.000 (0.843 to 1.186), 0.744 (0.615 to 0.900), and 0.684 (0.557 to 0.840) in female (P for trend <0.001), respectively. As a continuous variable in the fully-adjusted model, each one-standard deviation increase in percent change in SUA level was associated with an HR (95% CI) for incident MetS of 0.944 (0.906 to 0.982) in male (P=0.005) and 0.851 (0.801 to 0.905) in female (P<0.001). ConclusionThe current study demonstrated that increasing SUA level independently protected against the development of MetS, suggesting a possible role of SUA as an antioxidant in the pathogenesis of incident MetS.
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- High prevalence of hyperuricemia and the association with metabolic syndrome in the rural areas of Southwestern China: A structural equation modeling based on the Zhuang minority cohort
Xiaofen Tang, Shun Liu, Xiaoqiang Qiu, Li Su, Dongping Huang, Jun Liang, Yu Yang, Jennifer Hui Juan Tan, Xiaoyun Zeng, Yihong Xie Nutrition, Metabolism and Cardiovascular Diseases.2024; 34(2): 497. CrossRef - Predictive Value of Collagen Biomarkers in Advanced Chronic Kidney Disease Patients
Carina Ureche, Gianina Dodi, Adela Mihaela Șerban, Andreea Simona Covic, Luminița Voroneanu, Simona Hogaș, Radu Andy Sascău, Cristian Stătescu, Adrian Covic Biomolecules.2023; 13(2): 389. CrossRef - The bidirectional relationship between metabolic syndrome and hyperuricemia in China: A longitudinal study from CHARLS
Wen-Yu Chen, Yan-Peng Fu, Min Zhou Endocrine.2022; 76(1): 62. CrossRef - Correlation between Serum Oxidative Stress Level and Serum Uric Acid and Prognosis in Patients with Hepatitis B-Related Liver Cancer before Operation
Maowen Yu, Chaozhu Zhang, Hongbo Tang, Chaohui Xiao, Hangjun Che Journal of Healthcare Engineering.2022; 2022: 1. CrossRef - Association between metabolic syndrome and uric acid: a systematic review and meta-analysis
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Sen Chen, Nianwei Wu, Chuan Yu, Ying Xu, Chengfu Xu, Yuli Huang, Jian Zhao, Ningxiu Li, Xiong-Fei Pan Nutrition & Metabolism.2021;[Epub] CrossRef - Can biomarkers be used to improve diagnosis and prediction of metabolic syndrome in childhood cancer survivors? A systematic review
Vincent G. Pluimakers, Selveta S. van Santen, Marta Fiocco, Marie‐Christine E. Bakker, Aart J. van der Lelij, Marry M. van den Heuvel‐Eibrink, Sebastian J. C. M. M. Neggers Obesity Reviews.2021;[Epub] CrossRef - Inverse associations between serum urate and glycemic status in a general population and in persons with diabetes mellitus
Ichiro Wakabayashi Diabetology & Metabolic Syndrome.2020;[Epub] CrossRef - Association of Serum Uric Acid with Metabolic Syndrome and Its Components: A Mendelian Randomization Analysis
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- Obesity and Metabolic Syndrome
- Utility of Serum Albumin for Predicting Incident Metabolic Syndrome According to Hyperuricemia
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You-Bin Lee, Ji Eun Jun, Seung-Eun Lee, Jiyeon Ahn, Gyuri Kim, Jae Hwan Jee, Ji Cheol Bae, Sang-Man Jin, Jae Hyeon Kim
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Diabetes Metab J. 2018;42(6):529-537. Published online September 28, 2018
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DOI: https://doi.org/10.4093/dmj.2018.0012
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5,124
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- Background
Serum albumin and uric acid have been positively linked to metabolic syndrome (MetS). However, the association of MetS incidence with the combination of uric acid and albumin levels has not been investigated. We explored the association of albumin and uric acid with the risk of incident MetS in populations divided according to the levels of these two parameters. MethodsIn this retrospective longitudinal study, 11,613 non-MetS participants were enrolled among 24,185 individuals who had undergone at least four annual check-ups between 2006 and 2012. The risk of incident MetS was analyzed according to four groups categorized by the sex-specific medians of serum albumin and uric acid. ResultsDuring 55,407 person-years of follow-up, 2,439 cases of MetS developed. The risk of incident MetS increased as the uric acid category advanced in individuals with lower or higher serum albumin categories with hazard ratios (HRs) of 1.386 (95% confidence interval [CI], 1.236 to 1.554) or 1.314 (95% CI, 1.167 to 1.480). However, the incidence of MetS increased with higher albumin levels only in participants in the lower uric acid category with a HR of 1.143 (95% CI, 1.010 to 1.294). ConclusionHigher levels of albumin were associated with an increased risk of incident MetS only in individuals with lower uric acid whereas higher levels of uric acid were positively linked to risk of incident MetS regardless of albumin level.
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Vincent G. Pluimakers, Selveta S. van Santen, Marta Fiocco, Marie‐Christine E. Bakker, Aart J. van der Lelij, Marry M. van den Heuvel‐Eibrink, Sebastian J. C. M. M. Neggers Obesity Reviews.2021;[Epub] CrossRef - Heart Disease and Stroke Statistics—2020 Update: A Report From the American Heart Association
Salim S. Virani, Alvaro Alonso, Emelia J. Benjamin, Marcio S. Bittencourt, Clifton W. Callaway, April P. Carson, Alanna M. Chamberlain, Alexander R. Chang, Susan Cheng, Francesca N. Delling, Luc Djousse, Mitchell S.V. Elkind, Jane F. Ferguson, Myriam Forn Circulation.2020;[Epub] CrossRef - Association between dairy product consumption and hyperuricemia in an elderly population with metabolic syndrome
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- Obesity and Metabolic Syndrome
- Serum Calcium and the Risk of Incident Metabolic Syndrome: A 4.3-Year Retrospective Longitudinal Study
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Jong Ha Baek, Sang-Man Jin, Ji Cheol Bae, Jae Hwan Jee, Tae Yang Yu, Soo Kyoung Kim, Kyu Yeon Hur, Moon-Kyu Lee, Jae Hyeon Kim
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Diabetes Metab J. 2017;41(1):60-68. Published online December 26, 2016
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DOI: https://doi.org/10.4093/dmj.2017.41.1.60
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- Background
An association between serum calcium level and risk of metabolic syndrome (MetS) has been suggested in cross-sectional studies. This study aimed to evaluate the association between baseline serum calcium level and risk of incident MetS in a longitudinal study. MethodsWe conducted a retrospective longitudinal study of 12,706 participants without MetS who participated in a health screening program, had normal range serum calcium level at baseline (mean age, 51 years), and were followed up for 4.3 years (18,925 person-years). The risk of developing MetS was analyzed according to the baseline serum calcium levels. ResultsA total of 3,448 incident cases (27.1%) of MetS developed during the follow-up period. The hazard ratio (HR) for incident MetS did not increase with increasing tertile of serum calcium level in an age- and sex-matched model (P for trend=0.915). The HRs (95% confidence interval [CI]) for incident MetS comparing the second and the third tertiles to the first tertile of baseline serum calcium level were 0.91 (95% CI, 0.84 to 0.99) and 0.85 (95% CI, 0.78 to 0.92) in a fully adjusted model, respectively (P for trend=0.001). A decreased risk of incident MetS in higher tertiles of serum calcium level was observed in subjects with central obesity and/or a metabolically unhealthy state at baseline. ConclusionThere was no positive correlation between baseline serum calcium levels and incident risk of MetS in this longitudinal study. There was an association between higher serum calcium levels and decreased incident MetS in individuals with central obesity or two components of MetS at baseline.
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