- Obesity and Metabolic Syndrome
- Statins Increase Mitochondrial and Peroxisomal Fatty Acid Oxidation in the Liver and Prevent Non-Alcoholic Steatohepatitis in Mice
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Han-Sol Park, Jung Eun Jang, Myoung Seok Ko, Sung Hoon Woo, Bum Joong Kim, Hyun Sik Kim, Hye Sun Park, In-Sun Park, Eun Hee Koh, Ki-Up Lee
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Diabetes Metab J. 2016;40(5):376-385. Published online April 5, 2016
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DOI: https://doi.org/10.4093/dmj.2016.40.5.376
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Abstract
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- Background
Non-alcoholic fatty liver disease is the most common form of chronic liver disease in industrialized countries. Recent studies have highlighted the association between peroxisomal dysfunction and hepatic steatosis. Peroxisomes are intracellular organelles that contribute to several crucial metabolic processes, such as facilitation of mitochondrial fatty acid oxidation (FAO) and removal of reactive oxygen species through catalase or plasmalogen synthesis. Statins are known to prevent hepatic steatosis and non-alcoholic steatohepatitis (NASH), but underlying mechanisms of this prevention are largely unknown. MethodsSeven-week-old C57BL/6J mice were given normal chow or a methionine- and choline-deficient diet (MCDD) with or without various statins, fluvastatin, pravastatin, simvastatin, atorvastatin, and rosuvastatin (15 mg/kg/day), for 6 weeks. Histological lesions were analyzed by grading and staging systems of NASH. We also measured mitochondrial and peroxisomal FAO in the liver. ResultsStatin treatment prevented the development of MCDD-induced NASH. Both steatosis and inflammation or fibrosis grades were significantly improved by statins compared with MCDD-fed mice. Gene expression levels of peroxisomal proliferator-activated receptor α (PPARα) were decreased by MCDD and recovered by statin treatment. MCDD-induced suppression of mitochondrial and peroxisomal FAO was restored by statins. Each statin's effect on increasing FAO and improving NASH was independent on its effect of decreasing cholesterol levels. ConclusionStatins prevented NASH and increased mitochondrial and peroxisomal FAO via induction of PPARα. The ability to increase hepatic FAO is likely the major determinant of NASH prevention by statins. Improvement of peroxisomal function by statins may contribute to the prevention of NASH.
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Citations
Citations to this article as recorded by
- Organelle stress and alterations in interorganelle crosstalk during liver fibrosis
Saloni Sinha, Nora Hassan, Robert E. Schwartz Hepatology.2024; 79(2): 482. CrossRef - Statin therapy: a potential adjuvant to immunotherapies in hepatocellular carcinoma
Jiao Wang, Chengyu Liu, Ronghua Hu, Licheng Wu, Chuanzhou Li Frontiers in Pharmacology.2024;[Epub] CrossRef - Recent Progress in Anti‐Tumor Nanodrugs Based on Tumor Microenvironment Redox Regulation
Lan Yao, Xiang Zhu, Yunyi Shan, Liang Zhang, Jing Yao, Hui Xiong Small.2024;[Epub] CrossRef - Exploration of the Key Genes Involved in Non-alcoholic Fatty Liver Disease and Possible MicroRNA Therapeutic Targets
Ali Mahmoudi, Amin Jalili, Alexandra E. Butler, Seyed H. Aghaee-Bakhtiari, Tannaz Jamialahmadi, Amirhossein Sahebkar Journal of Clinical and Experimental Hepatology.2024; 14(4): 101365. CrossRef - Inflammation drives pathogenesis of early intestinal failure-associated liver disease
Scott C. Fligor, Savas T. Tsikis, Thomas I. Hirsch, Ashish Jain, Liang Sun, Shira Rockowitz, Kathleen M. Gura, Mark Puder Scientific Reports.2024;[Epub] CrossRef - A Systematic Review of Statins for the Treatment of Nonalcoholic Steatohepatitis: Safety, Efficacy, and Mechanism of Action
Shiqin Zhang, Xiaoling Ren, Bingzheng Zhang, Tian Lan, Bing Liu Molecules.2024; 29(8): 1859. CrossRef - Statins in Chronic Liver Disease: Review of the Literature and Future Role
Nguyen Pham, Jihane N. Benhammou Seminars in Liver Disease.2024; 44(02): 191. CrossRef - Team players in the pathogenesis of metabolic dysfunctions-associated steatotic liver disease: The basis of development of pharmacotherapy
Shahid Habib World Journal of Gastrointestinal Pathophysiology.2024;[Epub] CrossRef - Effects of metformin and simvastatin treatment on ultrastructural features of liver macrophages in HFD mice
Darko Ciric, Tamara Kravic-Stevovic, Vladimir Bumbasirevic, Sasa Petricevic, Sofija Jovanovic, Vladimir Trajkovic, Tamara Martinovic Ultrastructural Pathology.2023; 47(1): 1. CrossRef - Statins for the Treatment of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis: A Systematic Review and Meta-Analysis
Weiwei Dai, Baohong Xu, Peng Li, Junhua Weng American Journal of Therapeutics.2023; 30(1): e17. CrossRef - Atorvastatin Attenuates Diet-Induced Non-Alcoholic Steatohepatitis in APOE*3-Leiden Mice by Reducing Hepatic Inflammation
José A. Inia, Geurt Stokman, Elsbet J. Pieterman, Martine C. Morrison, Aswin L. Menke, Lars Verschuren, Martien P. M. Caspers, Martin Giera, J. Wouter Jukema, Anita M. van den Hoek, Hans M. G. Princen International Journal of Molecular Sciences.2023; 24(9): 7818. CrossRef - The interplay between nonalcoholic fatty liver disease and atherosclerotic cardiovascular disease
Alexandra C. Finney, Sandeep Das, Dhananjay Kumar, M. Peyton McKinney, Bishuang Cai, Arif Yurdagul, Oren Rom Frontiers in Cardiovascular Medicine.2023;[Epub] CrossRef - Serum metabolomic signatures of fatty acid oxidation defects differentiate host-response subphenotypes of acute respiratory distress syndrome
Tomeka L. Suber, Stacy G. Wendell, Steven J. Mullett, Benjamin Zuchelkowski, William Bain, Georgios D. Kitsios, Bryan J. McVerry, Prabir Ray, Anuradha Ray, Rama K. Mallampalli, Yingze Zhang, Faraaz Shah, Seyed Mehdi Nouraie, Janet S. Lee Respiratory Research.2023;[Epub] CrossRef - Statins on nonalcoholic fatty liver disease: A systematic review and meta-analysis of 14 RCTs
Haiyan Zhou, Maeda Toshiyoshi,, Wenli Zhao, Ye Zhao, Yan Zhao, Medicine.2023; 102(26): e33981. CrossRef - Atorvastatin rescues hyperhomocysteinemia-induced cognitive deficits and neuroinflammatory gene changes
Erica M. Weekman, Sherika N. Johnson, Colin B. Rogers, Tiffany L. Sudduth, Kevin Xie, Qi Qiao, David W. Fardo, Teodoro Bottiglieri, Donna M. Wilcock Journal of Neuroinflammation.2023;[Epub] CrossRef - Crosstalk between Lipids and Non-Alcoholic Fatty Liver Disease
Divyavani Gowda, Chandra Shekhar, Siddabasave Gowda B. Gowda, Yifan Chen, Shu-Ping Hui Livers.2023; 3(4): 687. CrossRef - Empagliflozin: Potential Protective Effects on Hepatocytes and Liver Outcomes in Streptozotocin -Diabetic Rats.
Alia Khwaldeh, Nour Al-Sawalha, Shefa' Aljabali, Ziad Shraideh, Sokiyna Ababneh, Roba Bdeir Biomedical and Pharmacology Journal.2023; 16(4): 2123. CrossRef - Is there a role of lipid-lowering therapies in the management of fatty liver disease?
Ismini Tzanaki, Aris P Agouridis, Michael S Kostapanos World Journal of Hepatology.2022; 14(1): 119. CrossRef - Bifidobacterium animalis subsp. lactis A6 Enhances Fatty Acid β-Oxidation of Adipose Tissue to Ameliorate the Development of Obesity in Mice
Yanxiong Huo, Guoping Zhao, Jinwang Li, Ran Wang, Fazheng Ren, Yixuan Li, Xiaoyu Wang Nutrients.2022; 14(3): 598. CrossRef - PharmOmics: A species- and tissue-specific drug signature database and gene-network-based drug repositioning tool
Yen-Wei Chen, Graciel Diamante, Jessica Ding, Thien Xuan Nghiem, Jessica Yang, Sung-Min Ha, Peter Cohn, Douglas Arneson, Montgomery Blencowe, Jennifer Garcia, Nima Zaghari, Paul Patel, Xia Yang iScience.2022; 25(4): 104052. CrossRef - Pleyotropic Effects of Statins Non-Alcoholic Fat Disease of the Liver Non-Alcoholic Steatohepatitis
И.Р. Агабабян, Ш.Ш. Садыкова Рецепт.2022; (2): 194. CrossRef - PPAR Alpha as a Metabolic Modulator of the Liver: Role in the Pathogenesis of Nonalcoholic Steatohepatitis (NASH)
Simona Todisco, Anna Santarsiero, Paolo Convertini, Giulio De Stefano, Michele Gilio, Vito Iacobazzi, Vittoria Infantino Biology.2022; 11(5): 792. CrossRef - Association between organochlorine pesticides and nonalcoholic fatty liver disease in the National Health and Nutrition Examination Survey 2003–2004
Hyunji Sang, Kyu-Na Lee, Chang Hee Jung, Kyungdo Han, Eun Hee Koh Scientific Reports.2022;[Epub] CrossRef - Integrating the contributions of mitochondrial oxidative metabolism to lipotoxicity and inflammation in NAFLD pathogenesis
Curtis C. Hughey, Patrycja Puchalska, Peter A. Crawford Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.2022; 1867(11): 159209. CrossRef - Supplementation of Lycium barbarum Polysaccharide Combined with Aerobic Exercise Ameliorates High-Fat-Induced Nonalcoholic Steatohepatitis via AMPK/PPARα/PGC-1α Pathway
Dou-Dou Li, Jia-Min Ma, Ming-Jing Li, Lu-Lu Gao, Yan-Na Fan, Yan-Nan Zhang, Xiu-Juan Tao, Jian-Jun Yang Nutrients.2022; 14(15): 3247. CrossRef - Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH)
Xiaohan Xu, Kyle L. Poulsen, Lijuan Wu, Shan Liu, Tatsunori Miyata, Qiaoling Song, Qingda Wei, Chenyang Zhao, Chunhua Lin, Jinbo Yang Signal Transduction and Targeted Therapy.2022;[Epub] CrossRef - Regulation of Hepatic Lipid and Glucose Metabolism by INSP3R1
Rachel J. Perry Diabetes.2022; 71(9): 1834. CrossRef - Effects of SLCO1B1 Genetic Variant on Metabolite Profile in Participants on Simvastatin Treatment
Lilian Fernandes Silva, Rowmika Ravi, Jagadish Vangipurapu, Anniina Oravilahti, Markku Laakso Metabolites.2022; 12(12): 1159. CrossRef - Acute and chronic effects of environmental realistic concentrations of simvastatin in danio rerio: evidences of oxidative alterations and endocrine disruptive activity
D. Rebelo, A.T. Correia, B. Nunes Environmental Toxicology and Pharmacology.2021; 81: 103522. CrossRef - Allopurinol ameliorates high fructose diet induced hepatic steatosis in diabetic rats through modulation of lipid metabolism, inflammation, and ER stress pathway
In-Jin Cho, Da-Hee Oh, Jin Yoo, You-Cheol Hwang, Kyu Jeung Ahn, Ho-Yeon Chung, Soung Won Jeong, Ju-Young Moon, Sang-Ho Lee, Sung-Jig Lim, In-Kyung Jeong Scientific Reports.2021;[Epub] CrossRef - Atorvastatin Modulates Bile Acid Homeostasis in Mice with Diet-Induced Nonalcoholic Steatohepatitis
Hana Lastuvkova, Fatemeh Alaei Faradonbeh, Jolana Schreiberova, Milos Hroch, Jaroslav Mokry, Hana Faistova, Zuzana Nova, Radomír Hyspler, Ivone Cristina Igreja Sa, Petr Nachtigal, Alzbeta Stefela, Petr Pavek, Stanislav Micuda International Journal of Molecular Sciences.2021; 22(12): 6468. CrossRef - PPARs as Metabolic Sensors and Therapeutic Targets in Liver Diseases
Hugo Christian Monroy-Ramirez, Marina Galicia-Moreno, Ana Sandoval-Rodriguez, Alejandra Meza-Rios, Arturo Santos, Juan Armendariz-Borunda International Journal of Molecular Sciences.2021; 22(15): 8298. CrossRef - Simvastatin affects the PPARα signaling pathway and causes oxidative stress and embryonic development interference in Mugilogobius abei
Chao Wang, Tianli Tang, Yimeng Wang, Xiangping Nie, Kaibin Li Aquatic Toxicology.2021; 239: 105951. CrossRef - Impact of statin use on the risk and prognosis of hepatocellular carcinoma: a meta-analysis
Jianfeng Wang, Xiaogang Li European Journal of Gastroenterology & Hepatology.2021; 33(12): 1603. CrossRef - Statins in Non-alcoholic Steatohepatitis
Jose D. Torres-Peña, Laura Martín-Piedra, Francisco Fuentes-Jiménez Frontiers in Cardiovascular Medicine.2021;[Epub] CrossRef - Comparison of the liver findings after simvastatin-treatment between Spontaneously Diabetic Torii-Leprfa (SDT fatty) rats and Sprague-Dawley rats
Tadakazu Takahashi, Yusuke Suzuki, Naohito Yamada, Kaoru Toyoda, Keisuke Goda, Katsunori Ryoke, Chizuru Matsuura, Akio Kobayashi, Shoichiro Sugai, Kayoko Shimoi Fundamental Toxicological Sciences.2020; 7(1): 41. CrossRef - Current and emerging pharmacotherapeutic interventions for the treatment of liver fibrosis
Joeri Lambrecht, Leo A. van Grunsven, Frank Tacke Expert Opinion on Pharmacotherapy.2020; 21(13): 1637. CrossRef - The Influence of Statins on the Aerobic Metabolism of Endothelial Cells
Izabela Broniarek, Karolina Dominiak, Lukasz Galganski, Wieslawa Jarmuszkiewicz International Journal of Molecular Sciences.2020; 21(4): 1485. CrossRef - NADPH Oxidase Inhibition in Fibrotic Pathologies
Karen Bernard, Victor J. Thannickal Antioxidants & Redox Signaling.2020; 33(6): 455. CrossRef - Pleiotropic Effects of Statins in the Light of Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis
Farah Ahsan, Federico Oliveri, Harshit K Goud, Zainab Mehkari, Lubna Mohammed, Moiz Javed, Aldanah Althwanay, Ian H Rutkofsky Cureus.2020;[Epub] CrossRef - Peroxisomal footprint in the pathogenesis of nonalcoholic steatohepatitis
S.M. Touhidul Islam, Jeseong Won, Mushfiquddin Khan, Kenneth D. Chavin, Inderjit Singh Annals of Hepatology.2020; 19(5): 466. CrossRef - Structural Basis for Activation of Human Sirtuin 6 by Fluvastatin
Weijie You, Clemens Steegborn ACS Medicinal Chemistry Letters.2020; 11(11): 2285. CrossRef - Specificity of transaminase activities in the prediction of drug-induced hepatotoxicity
Akio Kobayashi, Yusuke Suzuki, Shoichiro Sugai The Journal of Toxicological Sciences.2020; 45(9): 515. CrossRef - Disease-associated gut microbiome and metabolome changes in patients with chronic obstructive pulmonary disease
Kate L. Bowerman, Saima Firdous Rehman, Annalicia Vaughan, Nancy Lachner, Kurtis F. Budden, Richard Y. Kim, David L. A. Wood, Shaan L. Gellatly, Shakti D. Shukla, Lisa G. Wood, Ian A. Yang, Peter A. Wark, Philip Hugenholtz, Philip M. Hansbro Nature Communications.2020;[Epub] CrossRef - Simvastatin Reduces Hepatic Oxidative Stress and Endoplasmic Reticulum Stress in Nonalcoholic Steatohepatitis Experimental Model
Graziella Rodrigues, Andrea Janz Moreira, Silvia Bona, Elizângela Schemitt, Cláudio Augusto Marroni, Fábio Cangeri Di Naso, Alexandre Simões Dias, Thienne Rocha Pires, Jaqueline Nascimento Picada, Norma Possa Marroni Oxidative Medicine and Cellular Longevity.2019; 2019: 1. CrossRef - Impaired Peroxisomal Fitness in Obese Mice, a Vicious Cycle Exacerbating Adipocyte Dysfunction via Oxidative Stress
Lingjuan Piao, Debra Dorotea, Songling Jiang, Eun Hee Koh, Goo Taeg Oh, Hunjoo Ha Antioxidants & Redox Signaling.2019; 31(18): 1339. CrossRef - (5R)-5-hydroxytriptolide ameliorates liver lipid accumulation by suppressing lipid synthesis and promoting lipid oxidation in mice
Yunxia Dong, Henglei Lu, Qiang Li, Xinming Qi, Yuanchao Li, Zean Zhang, Jing Chen, Jin Ren Life Sciences.2019; 232: 116644. CrossRef - Simvastatin alleviates bone resorption in apical periodontitis possibly by inhibition of mitophagy‐related osteoblast apoptosis
C.‐N. Yang, S.‐H. Kok, H.‐W. Wang, J. Z.‐C. Chang, E. H.‐H. Lai, C.‐T. Shun, H. Yang, M.‐H. Chen, C.‐Y. Hong, S.‐K. Lin International Endodontic Journal.2019; 52(5): 676. CrossRef - Different Effects of Pravastatin on Preeclampsia-like Symptoms in Different Mouse Models
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Ji-Hye Kim, Jun Mi Lee, Jong-Hoon Kim, Kwang Rok Kim Biochemical and Biophysical Research Communications.2018; 503(3): 1415. CrossRef - Statin use and the risk of hepatocellular carcinoma in patients at high risk: A nationwide nested case-control study
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