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Hyun Hee Chung  (Chung HH) 2 Articles
The Relationship between Metformin and Cancer in Patients with Type 2 Diabetes
Hyun Hee Chung, Jun Sung Moon, Ji Sung Yoon, Hyoung Woo Lee, Kyu Chang Won
Diabetes Metab J. 2013;37(2):125-131.   Published online April 16, 2013
  • 3,734 View
  • 29 Download
  • 13 Crossref
AbstractAbstract PDFPubReader   

Recently, several studies reported that the cancer incidence in type 2 diabetes patients is higher than in the general population. Although a number of risks are shared between cancer and diabetes patients, there have been few studies of its correlation. We evaluated the influences of several factors including low density lipoprotein cholesterol (LDL-C), albuminuria and use of metformin on the risk of cancer in patients with type 2 diabetes.


We enrolled 1,320 patients with at least 5 years of follow-up and 73 patients were diagnosed with cancer during this period. The associations of the risk factors with cancer incidence were evaluated by multiple regression analysis. The subjects were placed into two subgroups based on metformin dosage (<1,000 mg/day, ≥1,000 mg/day) and we compared cancer incidence using analysis of covariance.


LDL-C and albuminuria were not significantly correlated with cancer risk. In contrast, metformin showed a reverse correlation with cancer risk (P=0.006; relative risk, 0.574). In the metformin nonadministration group, smoking, male gender, and high triglyceride levels tended to be contributing factors without statistical significance. Cancer occurence was lower in the low dose metformin group (less than 1,000 mg/day) (P=0.00).


These results suggest that the administration of low dose metformin in patients with type 2 diabetes may be associated with a reduced risk of cancer.


Citations to this article as recorded by  
  • Metformin Reduces Tumor Growth in a Murine Flank Schwannoma Model
    Sudhir Manickavel, Yolanda Hartman, Andrew Burns, Manuel A. Lora Gonzalez, Jason Warram, Erika Walsh, Jacob B. Hunter, Daniel E. Killeen
    Otology & Neurotology.2023; 44(9): 941.     CrossRef
  • Metformin induces TPC-1 cell apoptosis through endoplasmic reticulum stress-associated pathways in vitro and in vivo
    Jianwen Ye, Lei Qi, Kunlun Chen, Renfeng Li, Shengping Song, Chuang Zhou, Wenlong Zhai
    International Journal of Oncology.2019;[Epub]     CrossRef
  • Metformin Promotes Apoptosis but Suppresses Autophagy in Glucose-Deprived H4IIE Hepatocellular Carcinoma Cells
    Deok-Bae Park
    Diabetes & Metabolism Journal.2015; 39(6): 518.     CrossRef
  • Combination Therapy of Metformin and Statin May Decrease Hepatocellular Carcinoma Among Diabetic Patients in Asia
    Hsin-Hung Chen, Ming-Chia Lin, Chih-Hsin Muo, Su-Yin Yeh, Fung-Chang Sung, Chia-Hung Kao
    Medicine.2015; 94(24): e1013.     CrossRef
  • mitoNEET as a novel drug target for mitochondrial dysfunction
    Werner J. Geldenhuys, Thomas C. Leeper, Richard T. Carroll
    Drug Discovery Today.2014; 19(10): 1601.     CrossRef
  • Diabetes - Increased Risk for Cancers through Chromosomal Aberrations?
    Sudhaa Anand, Badari Nath, Radha Saraswathy
    Asian Pacific Journal of Cancer Prevention.2014; 15(11): 4571.     CrossRef
  • Oleanolic Acid Induces Metabolic Adaptation in Cancer Cells by Activating the AMP-Activated Protein Kinase Pathway
    Jia Liu, Lanhong Zheng, Ning Wu, Leina Ma, Jiateng Zhong, Ge Liu, Xiukun Lin
    Journal of Agricultural and Food Chemistry.2014; 62(24): 5528.     CrossRef
  • Association of Vitamin B12Deficiency and Metformin Use in Patients with Type 2 Diabetes
    Sun-Hye Ko, Sun-Hee Ko, Yu-Bae Ahn, Ki-Ho Song, Kyung-Do Han, Yong-Moon Park, Seung-Hyun Ko, Hye-Soo Kim
    Journal of Korean Medical Science.2014; 29(7): 965.     CrossRef
  • Metformin and Cancer Risk and Mortality: A Systematic Review and Meta-analysis Taking into Account Biases and Confounders
    Sara Gandini, Matteo Puntoni, Brandy M. Heckman-Stoddard, Barbara K. Dunn, Leslie Ford, Andrea DeCensi, Eva Szabo
    Cancer Prevention Research.2014; 7(9): 867.     CrossRef
  • Effects of Metformin on CD133+ Colorectal Cancer Cells in Diabetic Patients
    Yanfei Zhang, Meiping Guan, Zongji Zheng, Qian Zhang, Fang Gao, Yaoming Xue, Chunming Liu
    PLoS ONE.2013; 8(11): e81264.     CrossRef
  • AACE Comprehensive Diabetes Management Algorithm 2013 Endocrine Practice
    Héctor Eloy Tamez-Pérez, Stephanie Lissette Proskauer-Peña, Mayra Ivonne Hernández-Coria
    Endocrine Practice.2013; 19(4): 736.     CrossRef
  • Complications of Diabetes Therapy
    Sarah D. Corathers, Shawn Peavie, Marzieh Salehi
    Endocrinology and Metabolism Clinics of North America.2013; 42(4): 947.     CrossRef
  • Metformin and Cancer in Type 2 Diabetes
    Hyeong Kyu Park
    Diabetes & Metabolism Journal.2013; 37(2): 113.     CrossRef
Prevalence, Awareness, and Control of Hypertension among Diabetic Koreans
Hyun Hee Chung, Kyu Chang Won
Diabetes Metab J. 2011;35(4):337-339.   Published online August 31, 2011
  • 2,650 View
  • 35 Download
  • 5 Crossref


Citations to this article as recorded by  
  • The practice of consanguineous marriage and the risk of diabetes among offspring in the province of Tetouan (Morocco)
    Mohamed Hajjaji, AbdErrazzak Khadmaoui, Mohamed El Bakkali
    Arab Gulf Journal of Scientific Research.2024; 42(1): 30.     CrossRef
  • Insulin Resistance and Hypertension among Type 2 Diabetes Subjects in a Tertiary Institution in South East Nigeria
    Michael Chinweuba Abonyi, Ekenechukwu Esther Young, Chidinma Brenda Nwatu, Chidiebere Valentine Ugwueze, Marcellinus Okafor Nkpozi, Uzoma Chukwunonso Okechukwu, Maryann Kanayo Oham, John Aniebo Maluze, Fintan Chinweike Ekochin, Ginikachi Ginikachi Ucheze
    Nigerian Journal of Medicine.2023; 32(4): 422.     CrossRef
  • The prevalence of hypertension and its progression among patients with type 2 diabetes in Jordan
    Ahlam Bani Salameh, Dana Hyassat, Ahmad Suhail, Zaina Makahleh, Yousef Khader, Mohammed EL-Khateeb, Kamel Ajlouni
    Annals of Medicine and Surgery.2022; 73: 103162.     CrossRef
  • Gender dependent effects of fasting blood glucose levels and disease duration on biochemical markers in type 2 diabetics: A pilot study
    Abhijit A. Ghadge, Arundhati G. Diwan, Abhay M. Harsulkar, Aniket A. Kuvalekar
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2017; 11: S481.     CrossRef
  • Understanding Epistatic Interactions between Genes Targeted by Non-coding Regulatory Elements in Complex Diseases
    Min Kyung Sung, Hyoeun Bang, Jung Kyoon Choi
    Genomics & Informatics.2014; 12(4): 181.     CrossRef

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