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Hyo Jeong Kim  (Kim HJ) 2 Articles
Fracture Incidence and Risk of Osteoporosis in Female Type 2 Diabetic Patients in Korea
Jong Kwan Jung, Hyo Jeong Kim, Hong Kyu Lee, Sang Soo Kim, Chan Soo Shin, Jin Taek Kim
Diabetes Metab J. 2012;36(2):144-150.   Published online April 17, 2012
DOI: https://doi.org/10.4093/dmj.2012.36.2.144
  • 4,221 View
  • 38 Download
  • 15 Crossref
AbstractAbstract PDFPubReader   
Background

There are no published data regarding fracture risk in type 2 diabetic patients in Korea. In this study, we compared the fracture incidence and risk of osteoporosis of type 2 diabetic female patients with those in a non-diabetic hypertensive cohort.

Methods

The incidence of fracture in a type 2 diabetic cohort was compared with that in a non-diabetic hypertensive cohort over the course of 7 years. Female type 2 diabetic and non-diabetic hypertensive patients who visited Eulji General Hospital outpatient clinic from January 2004 to April 2004 were assigned to the diabetic cohort and the non-diabetic hypertensive cohort, respectively. Surveys on fracture event, use of anti-osteoporosis medications, and bone mineral density were performed.

Results

The number of fractures was 88 in the female diabetic cohort (n=1,268, 60.6±11.5 years) and 57 in the female non-diabetic hypertensive cohort (n=1,014, 61.4±11.7 years). The RR in the diabetic cohort was 1.38 (P=0.064; 95% confidence interval [CI], 0.98 to 1.94) when adjusted for age. Diabetic patients with microvascular complications (61.0%) showed a higher RR of 1.81 (P=0.014; 95% CI, 1.13 to 2.92) compared with those without these complications. The prevalence of osteoporosis was comparable between the groups, while use of anti-osteoporosis medication was more common in the diabetic cohort (12.8%) than in the hypertensive cohort (4.5%) (P<0.001).

Conclusion

In our study, a higher fracture risk was observed in female type 2 diabetics with microvascular complications. Special concern for this risk group is warranted.

Citations

Citations to this article as recorded by  
  • Research Progress on How to Prevent Osteoporosis in Diabetic Patients
    婷玉 牛
    Advances in Clinical Medicine.2022; 12(02): 1178.     CrossRef
  • Differences in the roles of types 1 and 2 diabetes in the susceptibility to the risk of fracture: a systematic review and meta-analysis
    Jiaqing Dou, Jing Wang, Qiu Zhang
    Diabetology & Metabolic Syndrome.2021;[Epub]     CrossRef
  • The risk of hip and non-vertebral fractures in type 1 and type 2 diabetes: A systematic review and meta-analysis update
    Tatiane Vilaca, Marian Schini, Susan Harnan, Anthea Sutton, Edith Poku, Isabel E. Allen, Steven R. Cummings, Richard Eastell
    Bone.2020; 137: 115457.     CrossRef
  • Diabetes mellitus and risk of low-energy fracture: a meta-analysis
    Jing Bai, Qian Gao, Chen Wang, Jia Dai
    Aging Clinical and Experimental Research.2020; 32(11): 2173.     CrossRef
  • Diabetes mellitus and the risk of fractures at specific sites: a meta-analysis
    Hao Wang, Ying Ba, Qian Xing, Jian-Ling Du
    BMJ Open.2019; 9(1): e024067.     CrossRef
  • The use of metformin, insulin, sulphonylureas, and thiazolidinediones and the risk of fracture: Systematic review and meta‐analysis of observational studies
    Khemayanto Hidayat, Xuan Du, Meng‐Jiao Wu, Bi‐Min Shi
    Obesity Reviews.2019; 20(10): 1494.     CrossRef
  • Bei Diabetikern an eine Osteoporose denken!
    Stephan Scharla
    MMW - Fortschritte der Medizin.2018; 160(21-22): 65.     CrossRef
  • Type 2 diabetes and risk of low-energy fractures in postmenopausal women: meta-analysis of observational studies
    Joanna Dytfeld, Michał Michalak
    Aging Clinical and Experimental Research.2017; 29(2): 301.     CrossRef
  • Risk of low-energy fracture in type 2 diabetes patients: a meta-analysis of observational studies
    P. Jia, L. Bao, H. Chen, J. Yuan, W. Liu, F. Feng, J. Li, H. Tang
    Osteoporosis International.2017; 28(11): 3113.     CrossRef
  • Comorbidity and its relationship with health service use and cost in community-living older adults with diabetes: A population-based study in Ontario, Canada
    Kathryn Fisher, Lauren Griffith, Andrea Gruneir, Dilzayn Panjwani, Sima Gandhi, Li (Lisa) Sheng, Amiram Gafni, Patterson Chris, Maureen Markle-Reid, Jenny Ploeg
    Diabetes Research and Clinical Practice.2016; 122: 113.     CrossRef
  • Type 2 diabetes mellitus and bone fragility: Special focus on bone imaging
    Yong Jun Choi, Yoon-Sok Chung
    Osteoporosis and Sarcopenia.2016; 2(1): 20.     CrossRef
  • Epidemiology of fractures in type 2 diabetes
    Ann V. Schwartz
    Bone.2016; 82: 2.     CrossRef
  • Efficacy and Safety of Weekly Alendronate Plus Vitamin D35600 IU versus Weekly Alendronate Alone in Korean Osteoporotic Women: 16-Week Randomized Trial
    Kwang Joon Kim, Yong-Ki Min, Jung-Min Koh, Yoon-Sok Chung, Kyoung Min Kim, Dong-Won Byun, In Joo Kim, Mikyung Kim, Sung-Soo Kim, Kyung Wan Min, Ki Ok Han, Hyoung Moo Park, Chan Soo Shin, Sung Hee Choi, Jong Suk Park, Dong Jin Chung, Ji Oh Mok, Hong Sun Ba
    Yonsei Medical Journal.2014; 55(3): 715.     CrossRef
  • Increased Risk of Fracture and Postfracture Adverse Events in Patients With Diabetes: Two Nationwide Population-Based Retrospective Cohort Studies
    Chien-Chang Liao, Chao-Shun Lin, Chun-Chuan Shih, Chun-Chieh Yeh, Yi-Cheng Chang, Yuan-Wen Lee, Ta-Liang Chen
    Diabetes Care.2014; 37(8): 2246.     CrossRef
  • Aortic Calcification and Bone Metabolism: The Relationship between Aortic Calcification, BMD, Vertebral Fracture, 25-Hydroxyvitamin D, and Osteocalcin
    Kwang Joon Kim, Kyoung Min Kim, Kyeong Hye Park, Han Seok Choi, Yumie Rhee, Yong Ho Lee, Bong Soo Cha, Myong Jin Kim, Sun Min Oh, J. Keenan Brown, Sung Kil Lim
    Calcified Tissue International.2012; 91(6): 370.     CrossRef
Increasing Trend in the Number of Severe Hypoglycemia Patients in Korea
Jin Taek Kim, Tae Jung Oh, Ye An Lee, Jun Ho Bae, Hyo Jeong Kim, Hye Seung Jung, Young Min Cho, Kyong Soo Park, Soo Lim, Hak Chul Jang, Hong Kyu Lee
Diabetes Metab J. 2011;35(2):166-172.   Published online April 30, 2011
DOI: https://doi.org/10.4093/dmj.2011.35.2.166
  • 65,535 View
  • 66 Download
  • 30 Crossref
AbstractAbstract PDFPubReader   
Background

To investigate whether the number of subjects with severe hypoglycemia who are brought to a hospital emergency department is increasing and to identify whether there have been changes in the demographic and clinical characteristics of those subjects.

Methods

We analyzed data from the Emergency Departments of two general hospitals in Seoul, Korea. We included data from all adult subjects with type 2 diabetes who presented to an emergency department with severe hypoglycemia between January 1, 2004 and December 30, 2009.

Results

A total of 740 cases of severe hypoglycemia were identified. The mean subject age was 69±12 years, mean duration of diabetes was 13.8±9.3 years, and 53.2% of subjects were receiving insulin therapy. We observed a sharp rise in the number of cases between 2006 and 2007. Stages 3-5 chronic kidney disease was diagnosed in 31.5% of subjects, and low C-peptide levels (<0.6 ng/mL) were found in 25.5%. The mean subject age, duration of diabetes, HbA1c level, and renal and insulin secretory function values did not change significantly during the study period. The proportion of glimepiride use increased, while use of gliclazide decreased among sulfonylurea users. Use of insulin analogues increased, while use of NPH/RI decreased among insulin users.

Conclusion

We identified a sharp increase in the number of subjects with severe hypoglycemia presenting to an emergency room since 2006. The clinical characteristics of these subjects did not change markedly during the study period. Nationwide studies are warranted to further clarify this epidemic of severe hypoglycemia.

Citations

Citations to this article as recorded by  
  • Hypoglycemia Unawareness—A Review on Pathophysiology and Clinical Implications
    Laura Hölzen, Bernd Schultes, Sebastian M. Meyhöfer, Svenja Meyhöfer
    Biomedicines.2024; 12(2): 391.     CrossRef
  • Hospital admissions trends for severe hypoglycemia in diabetes patients in Spain, 2005 to 2015
    Domingo Orozco-Beltrán, Alberto Guillen-Mollá, Ana María Cebrián-Cuenca, Jorge Navarro-Pérez, Vicente F. Gil-Guillén, Jose A. Quesada, Francisco J. Pomares-Gómez, Adriana Lopez-Pineda, Concepción Carratalá-Munuera
    Diabetes Research and Clinical Practice.2021; 171: 108565.     CrossRef
  • Trends and risk factors in severe hypoglycemia among individuals with type 2 diabetes in Korea
    Seung Eun Lee, Kyoung-Ah Kim, Kang Ju Son, Sun Ok Song, Kyeong Hye Park, Se Hee Park, Joo Young Nam
    Diabetes Research and Clinical Practice.2021; 178: 108946.     CrossRef
  • Predisposing factors of hypoglycemia in patients with type 2 diabetes mellitus presented with symptomatic hypoglycemia in a tertiary hospital of Bangladesh
    AjitK Paul, A.B.M. Kamrul-Hasan
    Journal of Diabetology.2020; 11(3): 163.     CrossRef
  • Real-world risk of hypoglycemia-related hospitalization in Japanese patients with type 2 diabetes using SGLT2 inhibitors: a nationwide cohort study
    Takeshi Horii, Yoichi Oikawa, Narumi Kunisada, Akira Shimada, Koichiro Atsuda
    BMJ Open Diabetes Research & Care.2020; 8(2): e001856.     CrossRef
  • Association between BMI and risk of severe hypoglycaemia in type 2 diabetes
    J.-S. Yun, Y.-M. Park, K. Han, S.-A. Cha, Y.-B. Ahn, S.-H. Ko
    Diabetes & Metabolism.2019; 45(1): 19.     CrossRef
  • The effects of hypoglycaemia and dementia on cardiovascular events, falls and fractures and all‐cause mortality in older individuals: A retrospective cohort study
    Katharina Mattishent, Kathryn Richardson, Ketan Dhatariya, George M. Savva, Chris Fox, Yoon K. Loke
    Diabetes, Obesity and Metabolism.2019; 21(9): 2076.     CrossRef
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    K. Mattishent, Y.K. Loke
    Journal of Diabetes and its Complications.2018; 32(8): 805.     CrossRef
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    Yuika Ikeda, Takekazu Kubo, Eisei Oda, Machiko Abe, Shigeru Tokita
    Journal of Diabetes Investigation.2018; 9(4): 925.     CrossRef
  • A study to evaluate the prevalence of impaired awareness of hypoglycaemia in adults with type 2 diabetes in outpatient clinic in a tertiary care centre in Singapore
    Ling Zhu, Li Chang Ang, Wee Boon Tan, Xiaohui Xin, Yong Mong Bee, Su-Yen Goh, Ming Ming Teh
    Therapeutic Advances in Endocrinology and Metabolism.2017; 8(5): 69.     CrossRef
  • Baseline-Corrected QT (QTc) Interval Is Associated with Prolongation of QTc during Severe Hypoglycemia in Patients with Type 2 Diabetes Mellitus
    Seon-Ah Cha, Jae-Seung Yun, Tae-Seok Lim, Yoon-Goo Kang, Kang-Min Lee, Ki-Ho Song, Ki-Dong Yoo, Yong-Moon Park, Seung-Hyun Ko, Yu-Bae Ahn
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    Jae-Seung Yun, Yu-Bae Ahn
    Diabetes & Metabolism Journal.2016; 40(1): 85.     CrossRef
  • 1,5-Anhydro-D-Glucitol Could Reflect Hypoglycemia Risk in Patients with Type 2 Diabetes Receiving Insulin Therapy
    Min Kyeong Kim, Hye Seung Jung, Soo Heon Kwak, Young Min Cho, Kyong Soo Park, Seong Yeon Kim
    Endocrinology and Metabolism.2016; 31(2): 284.     CrossRef
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    Seon-Ah Cha, Jae-Seung Yun, Tae-Seok Lim, Seawon Hwang, Eun-Jung Yim, Ki-Ho Song, Ki-Dong Yoo, Yong-Moon Park, Yu-Bae Ahn, Seung-Hyun Ko
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    Yong-ho Lee, Gyuri Kim, Eun Seok Kang
    The Journal of Korean Diabetes.2016; 17(1): 11.     CrossRef
  • Bi‐directional interaction between hypoglycaemia and cognitive impairment in elderly patients treated with glucose‐lowering agents: a systematic review and meta‐analysis
    K. Mattishent, Y. K. Loke
    Diabetes, Obesity and Metabolism.2016; 18(2): 135.     CrossRef
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    Barbara Bohn, Wolfgang Kerner, Jochen Seufert, Hans-Peter Kempe, Peter M. Jehle, Frank Best, Martin Füchtenbusch, Andreas Knauerhase, Martin Hofer, Joachim Rosenbauer, Reinhard W. Holl
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    Primary Care Diabetes.2015; 9(6): 490.     CrossRef
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    Yun-Mi Yong, Kyung-Mi Shin, Kang-Min Lee, Jae-Young Cho, Sun-Hye Ko, Min-Hyang Yoon, Tae-Won Kim, Jong-Hyun Jeong, Yong-Moon Park, Seung-Hyun Ko, Yu-Bae Ahn
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  • 1,5-Anhydroglucitol as a Useful Marker for Assessing Short-Term Glycemic Excursions in Type 1 Diabetes
    Hannah Seok, Ji Hye Huh, Hyun Min Kim, Byung-Wan Lee, Eun Seok Kang, Hyun Chul Lee, Bong Soo Cha
    Diabetes & Metabolism Journal.2015; 39(2): 164.     CrossRef
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    Mi Yeon Kang
    The Korean Journal of Internal Medicine.2015; 30(5): 648.     CrossRef
  • Cardiovascular Disease Predicts Severe Hypoglycemia in Patients with Type 2 Diabetes
    Jae-Seung Yun, Seung-Hyun Ko, Sun-Hye Ko, Ki-Ho Song, Ki-Dong Yoo, Kun-Ho Yoon, Yong-Moon Park, Yu-Bae Ahn
    Diabetes & Metabolism Journal.2015; 39(6): 498.     CrossRef
  • The Influence of Admission Hypoglycemia on Clinical Outcomes in Acute Myocardial Infarction Patients with Diabetes Mellitus
    Eun Jung Kim, Myung Ho Jeong, In Seok Jeong, Sang Gi Oh, Sang Hyung Kim, Young keun Ahn, Ju Han Kim, Young Jo Kim, Shung Chull Chae, Taek Jong Hong, In Whan Seong, Jei Keon Chae, Chong Jin Kim, Myeong Chan Cho, Ki Bae Seung, Hyo Soo Kim
    Korean Journal of Medicine.2014; 87(5): 565.     CrossRef
  • Corrected QT Interval Prolongation during Severe Hypoglycemia without Hypokalemia in Patients with Type 2 Diabetes
    Jae Won Beom, Jung Min Kim, Eun Joo Chung, Ju Yeong Kim, Seung Yeong Ko, Sang Don Na, Cheol Hwan Kim, Gun Park, Mi Yeon Kang
    Diabetes & Metabolism Journal.2013; 37(3): 190.     CrossRef
  • Presence of Macroalbuminuria Predicts Severe Hypoglycemia in Patients With Type 2 Diabetes
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  • Higher Morning to Evening Ratio in Total Dose of Twice-Daily Biphasic Insulin Analog Might Be Effective in Achieving Glucose Control in Patients with Poorly Controlled Type 2 Diabetes
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    Diabetes Technology & Therapeutics.2012; 14(6): 508.     CrossRef

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