- Drug/Regimen
- Pioglitazone as Add-on Therapy in Patients with Type 2 Diabetes Mellitus Inadequately Controlled with Dapagliflozin and Metformin: Double-Blind, Randomized, Placebo-Controlled Trial
-
Ji Hye Heo, Kyung Ah Han, Jun Hwa Hong, Hyun-Ae Seo, Eun-Gyoung Hong, Jae Myung Yu, Hye Seung Jung, Bong-Soo Cha
-
Diabetes Metab J. 2024;48(5):937-948. Published online February 2, 2024
-
DOI: https://doi.org/10.4093/dmj.2023.0314
-
-
5,145
View
-
393
Download
-
1
Crossref
-
Abstract
PDFSupplementary MaterialPubReader ePub
- Background
This study assessed the efficacy and safety of triple therapy with pioglitazone 15 mg add-on versus placebo in patients with type 2 diabetes mellitus (T2DM) inadequately controlled with metformin and dapagliflozin.
Methods In this multicenter, double-blind, randomized, phase 3 study, patients with T2DM with an inadequate response to treatment with metformin (≥1,000 mg/day) plus dapagliflozin (10 mg/day) were randomized to receive additional pioglitazone 15 mg/day (n=125) or placebo (n=125) for 24 weeks. The primary endpoint was the change in glycosylated hemoglobin (HbA1c) levels from baseline to week 24 (ClinicalTrials.gov identifier: NCT05101135).
Results At week 24, the adjusted mean change from baseline in HbA1c level compared with placebo was significantly greater with pioglitazone treatment (–0.47%; 95% confidence interval, –0.61 to –0.33; P<0.0001). A greater proportion of patients achieved HbA1c <7% or <6.5% at week 24 with pioglitazone compared to placebo as add-on to 10 mg dapagliflozin and metformin (56.8% vs. 28% for HbA1c <7%, and 23.2% vs. 9.6% for HbA1c <6.5%; P<0.0001 for all). The addition of pioglitazone also significantly improved triglyceride, highdensity lipoprotein cholesterol levels, and homeostatic model assessment of insulin resistance levels, while placebo did not. The incidence of treatment-emergent adverse events was similar between the groups, and the incidence of fluid retention-related side effects by pioglitazone was low (1.5%).
Conclusion Triple therapy with the addition of 15 mg/day of pioglitazone to dapagliflozin plus metformin was well tolerated and produced significant improvements in HbA1c in patients with T2DM inadequately controlled with dapagliflozin plus metformin.
-
Citations
Citations to this article as recorded by
- Ideal Combination of Oral Hypoglycemic Agents for Patients with Type 2 Diabetes Mellitus
Hye Soon Kim Diabetes & Metabolism Journal.2024; 48(5): 882. CrossRef
- Basic Research
- Glucolipotoxicity Suppressed Autophagy and Insulin Contents in Human Islets, and Attenuation of PERK Activity Enhanced Them in an ATG7-Dependent Manner
-
Seoil Moon, Ji Yoon Lim, Mirang Lee, Youngmin Han, Hongbeom Kim, Wooil Kwon, Jin-Young Jang, Mi Na Kim, Kyong Soo Park, Hye Seung Jung
-
Diabetes Metab J. 2024;48(2):231-241. Published online September 6, 2023
-
DOI: https://doi.org/10.4093/dmj.2022.0366
-
-
2,951
View
-
257
Download
-
2
Crossref
-
Abstract
PDFSupplementary MaterialPubReader ePub
- Background
Administration of pancreatic endoplasmic reticulum kinase inhibitor (PERKi) improved insulin secretion and hyperglycemia in obese diabetic mice. In this study, autophagic balance was studied whether to mediate it.
Methods Human islets were isolated from living patients without diabetes. PERKi GSK2606414 effects were evaluated in the islets under glucolipotoxicity by palmitate. Islet insulin contents and secretion were measured. Autophagic flux was assessed by microtubule associated protein 1 light chain 3 (LC3) conversion, a red fluorescent protein (RFP)-green fluorescent protein (GFP)- LC3 tandem assay, and P62 levels. For mechanical analyses, autophagy was suppressed using 3-methyladenine in mouse islets. Small interfering RNA for an autophagy-related gene autophagy related 7 (Atg7) was transfected to interfere autophagy.
Results PERKi administration to mice decreased diabetes-induced P62 levels in the islets. Glucolipotoxicity significantly increased PERK phosphorylation by 70% and decreased insulin contents by 50% in human islets, and addition of PERKi (40 to 80 nM) recovered both. PERKi also enhanced glucose-stimulated insulin secretion (6-fold). PERKi up-regulated LC3 conversion suppressed by glucolipotoxicity, and down-regulated P62 contents without changes in P62 transcription, indicating enhanced autophagic flux. Increased autophagosome-lysosome fusion by PERKi was visualized in mouse islets, where PERKi enhanced ATG7 bound to LC3. Suppression of Atg7 eliminated PERKi-induced insulin contents and secretion.
Conclusion This study provided functional changes of human islets with regard to autophagy under glucolipotoxicity, and suggested modulation of autophagy as an anti-diabetic mechanism of PERKi.
-
Citations
Citations to this article as recorded by
- Genetic knock-in of EIF2AK3 variants reveals differences in PERK activity in mouse liver and pancreas under endoplasmic reticulum stress
Shivesh Ghura, Noah R. Beratan, Xinglong Shi, Elena Alvarez-Periel, Sarah E. Bond Newton, Cagla Akay-Espinoza, Kelly L. Jordan-Sciutto Scientific Reports.2024;[Epub] CrossRef - Pancreatic β-Cells, Diabetes and Autophagy
Yang Ou, Yan-Li Zhao, Heng Su Endocrine Research.2024; : 1. CrossRef
- Pathophysiology
- Endoplasmic Reticulum Stress and Dysregulated Autophagy in Human Pancreatic Beta Cells
-
Seoil Moon, Hye Seung Jung
-
Diabetes Metab J. 2022;46(4):533-542. Published online July 27, 2022
-
DOI: https://doi.org/10.4093/dmj.2022.0070
-
-
5,649
View
-
271
Download
-
16
Web of Science
-
16
Crossref
-
Abstract
PDFPubReader ePub
- Pancreatic beta cell homeostasis is crucial for the synthesis and secretion of insulin; disruption of homeostasis causes diabetes, and is a treatment target. Adaptation to endoplasmic reticulum (ER) stress through the unfolded protein response (UPR) and adequate regulation of autophagy, which are closely linked, play essential roles in this homeostasis. In diabetes, the UPR and autophagy are dysregulated, which leads to beta cell failure and death. Various studies have explored methods to preserve pancreatic beta cell function and mass by relieving ER stress and regulating autophagic activity. To promote clinical translation of these research results to potential therapeutics for diabetes, we summarize the current knowledge on ER stress and autophagy in human insulin-secreting cells.
-
Citations
Citations to this article as recorded by
- Glucolipotoxicity Suppressed Autophagy and Insulin Contents in Human Islets, and Attenuation of PERK Activity Enhanced Them in an ATG7-Dependent Manner
Seoil Moon, Ji Yoon Lim, Mirang Lee, Youngmin Han, Hongbeom Kim, Wooil Kwon, Jin-Young Jang, Mi Na Kim, Kyong Soo Park, Hye Seung Jung Diabetes & Metabolism Journal.2024; 48(2): 231. CrossRef - Endoplasmic reticulum stress: A possible connection between intestinal inflammation and neurodegenerative disorders
Giorgio Vivacqua, Romina Mancinelli, Stefano Leone, Rosa Vaccaro, Ludovica Garro, Simone Carotti, Ludovica Ceci, Paolo Onori, Luigi Pannarale, Antonio Franchitto, Eugenio Gaudio, Arianna Casini Neurogastroenterology & Motility.2024;[Epub] CrossRef - Docosahexanoic Acid Attenuates Palmitate-Induced Apoptosis by Autophagy Upregulation via GPR120/mTOR Axis in Insulin-Secreting Cells
Seok-Woo Hong, Jinmi Lee, Sun Joon Moon, Hyemi Kwon, Se Eun Park, Eun-Jung Rhee, Won-Young Lee Endocrinology and Metabolism.2024; 39(2): 353. CrossRef - HIV-1 Tat-Mediated Human Müller Glial Cell Senescence Involves Endoplasmic Reticulum Stress and Dysregulated Autophagy
Uma Maheswari Deshetty, Nivedita Chatterjee, Shilpa Buch, Palsamy Periyasamy Viruses.2024; 16(6): 903. CrossRef - Gallic acid suppresses the progression of clear cell renal cell carcinoma through inducing autophagy via the PI3K/Akt/Atg16L1 signaling pathway
Tianxiang Zhang, Xi Zhang, Yang Fei, Jinsen Lu, Dairan Zhou, Li Zhang, Song Fan, Jun Zhou, Chaozhao Liang, Yang Su International Journal of Oncology.2024;[Epub] CrossRef - Dysregulation of pancreatic β-cell autophagy and the risk of type 2 diabetes
Hayder M. Al-kuraishy, Majid S. Jabir, Ali I. Al-Gareeb, Daniel J. Klionsky, Ali K. Albuhadily Autophagy.2024; : 1. CrossRef - Endoplasmic reticulum stress mechanisms and exercise intervention in type 2 diabetes mellitus
Qianyu Chen, Xiaoqin Zhao, Zujie Xu, Yiyao Liu Biomedicine & Pharmacotherapy.2024; 177: 117122. CrossRef - Tangningtongluo Tablet ameliorates pancreatic damage in diabetic mice by inducing autophagy and inhibiting the PI3K/Akt/mTOR signaling pathway
Ying Ren, Xiangka Hu, Mushuang Qi, Wanjun Zhu, Jin Li, Shuyu Yang, Chunmei Dai International Immunopharmacology.2024; 142: 113032. CrossRef - Ambient air fine particulate matter (PM10 and PM2.5) and risk of type 2 diabetes mellitus and mechanisms of effects: a global systematic review and meta-analysis
Salah Azizi, Mohammad Hadi Dehghani, Ramin Nabizadeh International Journal of Environmental Health Research.2024; : 1. CrossRef - Pancreatic islet remodeling in cotadutide-treated obese mice
Renata Spezani, Thatiany Souza Marinho, Luiz E. Macedo Cardoso, Marcia Barbosa Aguila, Carlos Alberto Mandarim-de-Lacerda Life Sciences.2023; 327: 121858. CrossRef - Modulation of Unfolded Protein Response Restores Survival and Function of β-Cells Exposed to the Endocrine Disruptor Bisphenol A
Laura Maria Daian, Gabriela Tanko, Andrei Mircea Vacaru, Luiza Ghila, Simona Chera, Ana-Maria Vacaru International Journal of Molecular Sciences.2023; 24(3): 2023. CrossRef - Interplay of skeletal muscle and adipose tissue: sarcopenic obesity
Min Jeong Park, Kyung Mook Choi Metabolism.2023; 144: 155577. CrossRef - Identification and analysis of type 2 diabetes-mellitus-associated autophagy-related genes
Kun Cui, Zhizheng Li Frontiers in Endocrinology.2023;[Epub] CrossRef - Sestrin2 in diabetes and diabetic complications
Xiaodan Zhang, Zirui Luo, Jiahong Li, Yaxuan Lin, Yu Li, Wangen Li Frontiers in Endocrinology.2023;[Epub] CrossRef - Crosstalk between autophagy and insulin resistance: evidence from different tissues
Asie Sadeghi, Maryam Niknam, Mohammad Amin Momeni-Moghaddam, Maryam Shabani, Hamid Aria, Alireza Bastin, Maryam Teimouri, Reza Meshkani, Hamed Akbari European Journal of Medical Research.2023;[Epub] CrossRef - Beta cell lipotoxicity in the development of type 2 diabetes: the need for species-specific understanding
Patricia Thomas, Meurig T. Gallagher, Gabriela Da Silva Xavier Frontiers in Endocrinology.2023;[Epub] CrossRef
- Drug/Regimen
- Comparison of Prevailing Insulin Regimens at Different Time Periods in Hospitalized Patients: A Real-World Experience from a Tertiary Hospital
-
Sun Joon Moon, Hun Jee Choe, Soo Heon Kwak, Hye Seung Jung, Kyong Soo Park, Young Min Cho
-
Diabetes Metab J. 2022;46(3):439-450. Published online October 20, 2021
-
DOI: https://doi.org/10.4093/dmj.2021.0065
-
-
Abstract
PDFSupplementary MaterialPubReader ePub
- Background
Prevailing insulin regimens for glycemic control in hospitalized patients have changed over time. We aimed to determine whether the current basal-bolus insulin (BBI) regimen is superior to the previous insulin regimen, mainly comprising split-mixed insulin therapy.
Methods This was a single tertiary center, retrospective observational study that included non-critically ill patients with type 2 diabetes mellitus who were treated with split-mixed insulin regimens from 2004 to 2007 (period 1) and with BBI from 2008 to 2018 (period 2). Patients from each period were analyzed after propensity score matching. The mean difference in glucose levels and the achievement of fasting and preprandial glycemic targets by day 6 of admission were assessed. The total daily insulin dose, incidence of hypoglycemia, and length of hospital stay were also evaluated.
Results Among 244 patients from each period, both fasting glucose (estimated mean±standard error, 147.4±3.1 mg/dL vs. 129.4±3.2 mg/dL, P<0.001, day 6) and preprandial glucose (177.7±2.8 mg/dL vs. 152.8±2.8 mg/dL, P<0.001, day 6) were lower in period 2 than in period 1. By day 6 of hospital admission, 42.6% and 67.2% of patients achieved a preprandial glycemic target of <140 mg/dL in periods 1 and 2, respectively (relative risk, 2.00; 95% confidence interval, 1.54 to 2.59), without an increased incidence of hypoglycemia. Length of stay was shorter in period 2 (10.23±0.26 days vs. 8.70±0.26 days, P<0.001).
Conclusion BBI improved glycemic control in a more efficacious manner than a split-mixed insulin regimen without increasing the risk of hypoglycemia in a hospital setting.
- Drug/Regimen
- Efficacy and Safety of Self-Titration Algorithms of Insulin Glargine 300 units/mL in Individuals with Uncontrolled Type 2 Diabetes Mellitus (The Korean TITRATION Study): A Randomized Controlled Trial
-
Jae Hyun Bae, Chang Ho Ahn, Ye Seul Yang, Sun Joon Moon, Soo Heon Kwak, Hye Seung Jung, Kyong Soo Park, Young Min Cho
-
Diabetes Metab J. 2022;46(1):71-80. Published online June 16, 2021
-
DOI: https://doi.org/10.4093/dmj.2020.0274
-
-
10,469
View
-
468
Download
-
2
Web of Science
-
4
Crossref
-
Graphical Abstract
Abstract
PDFSupplementary MaterialPubReader ePub
- Background
To compare the efficacy and safety of two insulin self-titration algorithms, Implementing New Strategies with Insulin Glargine for Hyperglycemia Treatment (INSIGHT) and EDITION, for insulin glargine 300 units/mL (Gla-300) in Korean individuals with uncontrolled type 2 diabetes mellitus (T2DM).
Methods In a 12-week, randomized, open-label trial, individuals with uncontrolled T2DM requiring basal insulin were randomized to either the INSIGHT (adjusted by 1 unit/day) or EDITION (adjusted by 3 units/week) algorithm to achieve a fasting self-monitoring of blood glucose (SMBG) in the range of 4.4 to 5.6 mmol/L. The primary outcome was the proportion of individuals achieving a fasting SMBG ≤5.6 mmol/L without noct urnal hypoglycemia at week 12.
Results Of 129 individuals (age, 64.1±9.5 years; 66 [51.2%] women), 65 and 64 were randomized to the INSIGHT and EDITION algorithms, respectively. The primary outcome of achievement was comparable between the two groups (24.6% vs. 23.4%, P=0.876). Compared with the EDITION group, the INSIGHT group had a greater reduction in 7-point SMBG but a similar decrease in fasting plasma glucose and glycosylated hemoglobin. The increment of total daily insulin dose was significantly higher in the INSIGHT group than in the EDITION group (between-group difference: 5.8±2.7 units/day, P=0.033). However, body weight was significantly increased only in the EDITION group (0.6±2.4 kg, P=0.038). There was no difference in the occurrence of hypoglycemia between the two groups. Patient satisfaction was significantly increased in the INSIGHT group (P=0.014).
Conclusion The self-titration of Gla-300 using the INSIGHT algorithm was effective and safe compared with that using the EDITION algorithm in Korean individuals with uncontrolled T2DM (ClinicalTrials.gov number: NCT03406663).
-
Citations
Citations to this article as recorded by
- Time for Using Machine Learning for Dose Guidance in Titration of People With Type 2 Diabetes? A Systematic Review of Basal Insulin Dose Guidance
Camilla Heisel Nyholm Thomsen, Stine Hangaard, Thomas Kronborg, Peter Vestergaard, Ole Hejlesen, Morten Hasselstrøm Jensen Journal of Diabetes Science and Technology.2024; 18(5): 1185. CrossRef - Comparative efficacy and safety of weekly tirzepatide versus weekly insulin in type 2 diabetes: A network meta‐analysis of randomized clinical trials
Hazem Ayesh, Sajida Suhail, Suhail Ayesh, Kevin Niswender Diabetes, Obesity and Metabolism.2024; 26(9): 3801. CrossRef - Basal insulin titration algorithms in patients with type 2 diabetes: the simplest is the best (?)
V.I. Katerenchuk INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine).2023; 19(1): 72. CrossRef - Issues of insulin therapy for type 2 diabetes and ways to solve them
V.I. Katerenchuk, A.V. Katerenchuk INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine).2023; 19(3): 240. CrossRef
- Letter: Early Assessment of the Risk for Gestational Diabetes Mellitus: Can Fasting Parameters of Glucose Metabolism Contribute to Risk Prediction? (Diabetes Metab J 2019;43:785–93)
-
Ye Seul Yang, Hye Seung Jung
-
Diabetes Metab J. 2020;44(1):199-200. Published online February 21, 2020
-
DOI: https://doi.org/10.4093/dmj.2020.0023
-
-
3,458
View
-
54
Download
-
1
Crossref
-
PDFPubReader
-
Citations
Citations to this article as recorded by
- Comparison of the Effect of Face-to-face and Social Media-based Training on the Self-care of Women with Gestational Diabetes Mellitus (GDM) in Birjand
Mohaddeseh Hosseinzadeh, Gholamreza Sharifzadeh, Mostafa Hosseinzadeh, Marzieh Torshizi Modern Care Journal.2022;[Epub] CrossRef
- Genetics
- Identification of Two Cases of Ciliopathy-Associated Diabetes and Their Mutation Analysis Using Whole Exome Sequencing
-
Min Kyeong Kim, Soo Heon Kwak, Shinae Kang, Hye Seung Jung, Young Min Cho, Seong Yeon Kim, Kyong Soo Park
-
Diabetes Metab J. 2015;39(5):439-443. Published online October 22, 2015
-
DOI: https://doi.org/10.4093/dmj.2015.39.5.439
-
-
5,249
View
-
60
Download
-
5
Web of Science
-
6
Crossref
-
Abstract
PDFPubReader
- Background
Alström syndrome and Bardet-Biedl syndrome are autosomal recessively inherited ciliopathies with common characteristics of obesity, diabetes, and blindness. Alström syndrome is caused by a mutation in the ALMS1 gene, and Bardet-Biedl syndrome is caused by mutations in BBS1-16 genes. Herein we report genetically confirmed cases of Alström syndrome and Bardet-Biedl syndrome in Korea using whole exome sequencing. MethodsExome capture was done using SureSelect Human All Exon Kit V4+UTRs (Agilent Technologies). HiSeq2000 system (Illumina) was used for massive parallel sequencing. Sanger sequencing was used for genotype confirmation and familial cosegregation analysis. ResultsA 21-year old Korean woman was clinically diagnosed with Alström syndrome. She had diabetes, blindness, obesity, severe insulin resistance, and hearing loss. Whole exome sequencing revealed a nonsense mutation in exon 10 of ALMS1 (c.8776C>T, p.R2926X) and a seven base-pair deletion resulting in frameshift mutation in exon 8 (c.6410_6416del, p.2137_2139del). A 24-year-old Korean man had Bardet-Biedl syndrome with diabetes, blindness, obesity, and a history of polydactyly. Whole exome sequencing revealed a nonsynonymous mutation in exon 11 of the BBS1 gene (c.1061A>G, p.E354G) and mutation at the normal splicing recognition site of exon 7 of the BBS1 gene (c.519-1G>T). ConclusionWe found novel compound heterozygous mutations of Alström syndrome and Bardet-Biedl syndrome using whole exome sequencing. The whole exome sequencing successfully identified novel genetic variants of ciliopathy-associated diabetes.
-
Citations
Citations to this article as recorded by
- Genotype–phenotype associations in Alström syndrome: a systematic review and meta-analysis
Brais Bea-Mascato, Diana Valverde Journal of Medical Genetics.2024; 61(1): 18. CrossRef - Differentiating monogenic and syndromic obesities from polygenic obesity: Assessment, diagnosis, and management
Angela K. Fitch, Sonali Malhotra, Rushika Conroy Obesity Pillars.2024; 11: 100110. CrossRef - Whole exome sequencing identifies rare biallelic ALMS1 missense and stop gain mutations in familial Alström syndrome patients
Naglaa M. Kamal, Ahmed N. Sahly, Babajan Banaganapalli, Omran M. Rashidi, Preetha J. Shetty, Jumana Y. Al-Aama, Noor A. Shaik, Ramu Elango, Omar I. Saadah Saudi Journal of Biological Sciences.2020; 27(1): 271. CrossRef - Established and emerging strategies to crack the genetic code of obesity
V. Tam, M. Turcotte, D. Meyre Obesity Reviews.2019; 20(2): 212. CrossRef - Identifying Pathogenic Variants of Monogenic Diabetes Using Targeted Panel Sequencing in an East Asian Population
Seung Shin Park, Se Song Jang, Chang Ho Ahn, Jung Hee Kim, Hye Seung Jung, Young Min Cho, Young Ah Lee, Choong Ho Shin, Jong Hee Chae, Jae Hyun Kim, Sung Hee Choi, Hak C Jang, Jee Cheol Bae, Jong Cheol Won, Sung-Hoon Kim, Jong-Il Kim, Soo Heon Kwak, Kyong The Journal of Clinical Endocrinology & Metabolism.2019; 104(9): 4188. CrossRef - Whole exome sequencing as a diagnostic tool for patients with ciliopathy-like phenotypes
Sheila Castro-Sánchez, María Álvarez-Satta, Mohamed A. Tohamy, Sergi Beltran, Sophia Derdak, Diana Valverde, Anand Swaroop PLOS ONE.2017; 12(8): e0183081. CrossRef
- Response: Normal Glucose Tolerance with a High 1-Hour Postload Plasma Glucose Level Exhibits Decreased β-Cell Function Similar to Impaired Glucose Tolerance (Diabetes Metab J 2015;39:147-53)
-
Tae Jung Oh, Se Hee Min, Chang Ho Ahn, Eun Ky Kim, Soo Heon Kwak, Hye Seung Jung, Kyong Soo Park, Young Min Cho
-
Diabetes Metab J. 2015;39(3):270-271. Published online June 15, 2015
-
DOI: https://doi.org/10.4093/dmj.2015.39.3.270
-
-
3,725
View
-
36
Download
-
1
Crossref
-
PDFPubReader
-
Citations
Citations to this article as recorded by
- Prevalence of Impaired Glucose Tolerance/Prediabetes in Local Adult Obese Population Presenting to A Tertiary Care Hospital
Niktash Khan Hadi, Muhammad Salman Aamir, Tahir Ghaffar, Sulaiman Khan, Siraj ul Islam, Shafiullah Khan, Nizamuddin ., Muhammad Ali Pakistan Journal of Health Sciences.2023; : 84. CrossRef
- Normal Glucose Tolerance with a High 1-Hour Postload Plasma Glucose Level Exhibits Decreased β-Cell Function Similar to Impaired Glucose Tolerance
-
Tae Jung Oh, Se Hee Min, Chang Ho Ahn, Eun Ky Kim, Soo Heon Kwak, Hye Seung Jung, Kyong Soo Park, Young Min Cho
-
Diabetes Metab J. 2015;39(2):147-153. Published online March 9, 2015
-
DOI: https://doi.org/10.4093/dmj.2015.39.2.147
-
-
4,939
View
-
51
Download
-
18
Web of Science
-
16
Crossref
-
Abstract
PDFPubReader
- Background
Subjects with normal glucose tolerance (NGT) who have a high 1-hour postload plasma glucose level (≥155 mg/dL; NGT 1 hour-high) have been shown to be at higher risk for type 2 diabetes than subjects with NGT 1 hour-low postload plasma glucose level (<155 mg/dL). We compared β-cell function in subjects with NGT 1 hour-high, NGT 1 hour-low, and impaired glucose tolerance (IGT). MethodsWe classified subjects into NGT 1 hour-low (n=149), NGT 1 hour-high (n=43), and IGT (n=52). The β-cell function was assessed based on insulinogenic index (IGI), oral disposition index (DI), and insulin secretion-sensitivity index-2 (ISSI-2). ResultsInsulin sensitivity was comparable between the subjects with NGT 1 hour-high and NGT 1 hour-low. The β-cell function with/without adjusting insulin sensitivity was significantly different among the three groups. The IGI (pmol/mmol) was 116.8±107.3 vs. 64.8±47.8 vs. 65.8±80.6 (P=0.141), oral DI was 3.5±4.2 vs. 1.8±1.4 vs. 1.8±3.1 (P<0.001), and ISSI-2 was 301.2±113.7 vs. 213.2±67.3 vs. 172.5±87.5 (P<0.001) in NGT 1 hour-low, NGT 1 hour-high, and IGT, respectively. Post hoc analyses revealed that oral DI and ISSI-2 were significantly different between NGT 1 hour-low and NGT 1 hour-high but comparable between NGT 1 hour-high and IGT. ConclusionAmong Korean subjects with NGT, those who have a higher 1-hour postload glucose level have a compromised insulin-sensitivity adjusted β-cell function to a similar degree as IGT subjects.
-
Citations
Citations to this article as recorded by
- Triglyceride-glucose index predicts type 2 diabetes mellitus more effectively than oral glucose tolerance test-derived insulin sensitivity and secretion markers
Min Jin Lee, Ji Hyun Bae, Ah Reum Khang, Dongwon Yi, Mi Sook Yun, Yang Ho Kang Diabetes Research and Clinical Practice.2024; 210: 111640. CrossRef - Pathophysiological characteristics of subjects with intermediate hyperglycemia and type 2 diabetes identified by 1-hour plasma glucose during an oral glucose tolerance test
Chiara M.A. Cefalo, Alessia Riccio, Teresa Vanessa Fiorentino, Elena Succurro, Gaia Chiara Mannino, Maria Perticone, Angela Sciacqua, Francesco Andreozzi, Giorgio Sesti Diabetes Research and Clinical Practice.2024; 217: 111856. CrossRef - Lipid profile is similar in both subjects with high 1-hour postload glucose and 2-hour postload glucose and is related to cardio-metabolic profile in prediabetes
Rumyana Dimova, Nevena Chakarova, Mina Serdarova, Tsvetalina Tankova Journal of Diabetes and its Complications.2024; 38(11): 108869. CrossRef - 1-Hour Postload Glucose: Early Screening for High Risk of Type 2 Diabetes in Koreans With Normal Fasting Glucose
Min Jin Lee, Ji Hyun Bae, Ah Reum Khang, Dongwon Yi, Joo Yeon Kim, Su Hyun Kim, Dong Hee Kim, Dasol Kang, Sujin Park, Yun Kyung Jeon, Sang Soo Kim, Bo Hyun Kim, Mi Sook Yun, Yang Ho Kang The Journal of Clinical Endocrinology & Metabolism.2024;[Epub] CrossRef - Pancreatic fat accumulation is associated with decreased β‐cell function and deterioration in glucose tolerance in Korean adults
Sang Ouk Chin, You‐Cheol Hwang, In‐Jin Cho, In‐Kyung Jeong, Kyu Jeung Ahn, Ho Yeon Chung Diabetes/Metabolism Research and Reviews.2021;[Epub] CrossRef - Indirect insulin resistance detection: Current clinical trends and laboratory limitations
Sylwia Placzkowska, Lilla Pawlik-Sobecka, Izabela Kokot, Agnieszka Piwowar Biomedical Papers.2019; 163(3): 187. CrossRef - Clinical Implications of Using Post-Challenge Plasma Glucose Levels for Early Diagnosis of Type 2 Diabetes Mellitus in Older Individuals
Kyong Hye Joung, Sang Hyun Ju, Ji Min Kim, Sorim Choung, Jae Min Lee, Kang Seo Park, Hyun Jin Kim, Bon Jeong Ku Diabetes & Metabolism Journal.2018; 42(2): 147. CrossRef - The 1-h post-load plasma glucose as a novel biomarker for diagnosing dysglycemia
Ram Jagannathan, Martin Buysschaert, José Luis Medina, Karin Katz, Sarah Musleh, Brenda Dorcely, Michael Bergman Acta Diabetologica.2018; 55(6): 519. CrossRef - Elevated 1‐hour post‐load plasma glucose identifies obese youth with abnormal glucose metabolism and an unfavourable inflammatory profile
Anastasios Serbis, Vasileios Giapros, Anna Challa, Nikolaos Chaliasos, Ekaterini Siomou Clinical Endocrinology.2018; 89(6): 757. CrossRef - One‐hour postload plasma glucose concentration in people with normal glucose homeostasis predicts future diabetes mellitus: a 12‐year community‐based cohort study
Tae Jung Oh, Soo Lim, Kyoung Min Kim, Jae Hoon Moon, Sung Hee Choi, Young Min Cho, Kyong Soo Park, HakChul Jang, Nam H. Cho Clinical Endocrinology.2017; 86(4): 513. CrossRef - An elevated 1-h post- load glucose level during the oral glucose tolerance test detects prediabetes
Martin Buysschaert, Michael Bergman, Donald Yanogo, Ram Jagannathan, Benoit Buysschaert, Vanessa Preumont Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2017; 11(2): 137. CrossRef - Delayed insulin secretion response during an OGTT is associated with an increased risk for incidence of diabetes in NGT subjects
Yun Sun, Junfeng Han, Ziwei Lin, Lige Song, Chen Wang, Weiping Jia Journal of Diabetes and its Complications.2016; 30(8): 1537. CrossRef - Postprandial Hyperglycemia
Tae Jung Oh The Journal of Korean Diabetes.2016; 17(4): 233. CrossRef - β-Cell Function and Insulin Sensitivity in Normal Glucose-Tolerant Subjects Stratified by 1-Hour Plasma Glucose Values
Miranda M. Priya, Anandakumar Amutha, T.A. Pramodkumar, Harish Ranjani, Saravanan Jebarani, Kuppan Gokulakrishnan, Rajendra Pradeepa, Ranjit Unnikrishnan, Ranjit Mohan Anjana, Viswanathan Mohan Diabetes Technology & Therapeutics.2016; 18(1): 29. CrossRef - Response: Normal Glucose Tolerance with a High 1-Hour Postload Plasma Glucose Level Exhibits Decreased β-Cell Function Similar to Impaired Glucose Tolerance (Diabetes Metab J2015;39:147-53)
Tae Jung Oh, Se Hee Min, Chang Ho Ahn, Eun Ky Kim, Soo Heon Kwak, Hye Seung Jung, Kyong Soo Park, Young Min Cho Diabetes & Metabolism Journal.2015; 39(3): 270. CrossRef - Letter: Normal Glucose Tolerance with a High 1-Hour Postload Plasma Glucose Level Exhibits Decreased β-Cell Function Similar to Impaired Glucose Tolerance (Diabetes Metab J2015;39:147-53)
Hee Kyung Kim Diabetes & Metabolism Journal.2015; 39(3): 268. CrossRef
- Increasing Trend in the Number of Severe Hypoglycemia Patients in Korea
-
Jin Taek Kim, Tae Jung Oh, Ye An Lee, Jun Ho Bae, Hyo Jeong Kim, Hye Seung Jung, Young Min Cho, Kyong Soo Park, Soo Lim, Hak Chul Jang, Hong Kyu Lee
-
Diabetes Metab J. 2011;35(2):166-172. Published online April 30, 2011
-
DOI: https://doi.org/10.4093/dmj.2011.35.2.166
-
-
65,535
View
-
68
Download
-
30
Crossref
-
Abstract
PDFPubReader
- Background
To investigate whether the number of subjects with severe hypoglycemia who are brought to a hospital emergency department is increasing and to identify whether there have been changes in the demographic and clinical characteristics of those subjects. MethodsWe analyzed data from the Emergency Departments of two general hospitals in Seoul, Korea. We included data from all adult subjects with type 2 diabetes who presented to an emergency department with severe hypoglycemia between January 1, 2004 and December 30, 2009. ResultsA total of 740 cases of severe hypoglycemia were identified. The mean subject age was 69±12 years, mean duration of diabetes was 13.8±9.3 years, and 53.2% of subjects were receiving insulin therapy. We observed a sharp rise in the number of cases between 2006 and 2007. Stages 3-5 chronic kidney disease was diagnosed in 31.5% of subjects, and low C-peptide levels (<0.6 ng/mL) were found in 25.5%. The mean subject age, duration of diabetes, HbA1c level, and renal and insulin secretory function values did not change significantly during the study period. The proportion of glimepiride use increased, while use of gliclazide decreased among sulfonylurea users. Use of insulin analogues increased, while use of NPH/RI decreased among insulin users. ConclusionWe identified a sharp increase in the number of subjects with severe hypoglycemia presenting to an emergency room since 2006. The clinical characteristics of these subjects did not change markedly during the study period. Nationwide studies are warranted to further clarify this epidemic of severe hypoglycemia.
-
Citations
Citations to this article as recorded by
- Hypoglycemia Unawareness—A Review on Pathophysiology and Clinical Implications
Laura Hölzen, Bernd Schultes, Sebastian M. Meyhöfer, Svenja Meyhöfer Biomedicines.2024; 12(2): 391. CrossRef - Hospital admissions trends for severe hypoglycemia in diabetes patients in Spain, 2005 to 2015
Domingo Orozco-Beltrán, Alberto Guillen-Mollá, Ana María Cebrián-Cuenca, Jorge Navarro-Pérez, Vicente F. Gil-Guillén, Jose A. Quesada, Francisco J. Pomares-Gómez, Adriana Lopez-Pineda, Concepción Carratalá-Munuera Diabetes Research and Clinical Practice.2021; 171: 108565. CrossRef - Trends and risk factors in severe hypoglycemia among individuals with type 2 diabetes in Korea
Seung Eun Lee, Kyoung-Ah Kim, Kang Ju Son, Sun Ok Song, Kyeong Hye Park, Se Hee Park, Joo Young Nam Diabetes Research and Clinical Practice.2021; 178: 108946. CrossRef - Predisposing factors of hypoglycemia in patients with type 2 diabetes mellitus presented with symptomatic hypoglycemia in a tertiary hospital of Bangladesh
AjitK Paul, A.B.M. Kamrul-Hasan Journal of Diabetology.2020; 11(3): 163. CrossRef - Real-world risk of hypoglycemia-related hospitalization in Japanese patients with type 2 diabetes using SGLT2 inhibitors: a nationwide cohort study
Takeshi Horii, Yoichi Oikawa, Narumi Kunisada, Akira Shimada, Koichiro Atsuda BMJ Open Diabetes Research & Care.2020; 8(2): e001856. CrossRef - Association between BMI and risk of severe hypoglycaemia in type 2 diabetes
J.-S. Yun, Y.-M. Park, K. Han, S.-A. Cha, Y.-B. Ahn, S.-H. Ko Diabetes & Metabolism.2019; 45(1): 19. CrossRef - The effects of hypoglycaemia and dementia on cardiovascular events, falls and fractures and all‐cause mortality in older individuals: A retrospective cohort study
Katharina Mattishent, Kathryn Richardson, Ketan Dhatariya, George M. Savva, Chris Fox, Yoon K. Loke Diabetes, Obesity and Metabolism.2019; 21(9): 2076. CrossRef - Detection of asymptomatic drug-induced hypoglycemia using continuous glucose monitoring in older people – Systematic review
K. Mattishent, Y.K. Loke Journal of Diabetes and its Complications.2018; 32(8): 805. CrossRef - Incidence rate and patient characteristics of severe hypoglycemia in treated type 2 diabetes mellitus patients in Japan: Retrospective Diagnosis Procedure Combination database analysis
Yuika Ikeda, Takekazu Kubo, Eisei Oda, Machiko Abe, Shigeru Tokita Journal of Diabetes Investigation.2018; 9(4): 925. CrossRef - A study to evaluate the prevalence of impaired awareness of hypoglycaemia in adults with type 2 diabetes in outpatient clinic in a tertiary care centre in Singapore
Ling Zhu, Li Chang Ang, Wee Boon Tan, Xiaohui Xin, Yong Mong Bee, Su-Yen Goh, Ming Ming Teh Therapeutic Advances in Endocrinology and Metabolism.2017; 8(5): 69. CrossRef - Baseline-Corrected QT (QTc) Interval Is Associated with Prolongation of QTc during Severe Hypoglycemia in Patients with Type 2 Diabetes Mellitus
Seon-Ah Cha, Jae-Seung Yun, Tae-Seok Lim, Yoon-Goo Kang, Kang-Min Lee, Ki-Ho Song, Ki-Dong Yoo, Yong-Moon Park, Seung-Hyun Ko, Yu-Bae Ahn Diabetes & Metabolism Journal.2016; 40(6): 463. CrossRef - Response: Cardiovascular Disease Predicts Severe Hypoglycemia in Patients with Type 2 Diabetes (Diabetes Metab J 2015;39:498-506)
Jae-Seung Yun, Yu-Bae Ahn Diabetes & Metabolism Journal.2016; 40(1): 85. CrossRef - 1,5-Anhydro-D-Glucitol Could Reflect Hypoglycemia Risk in Patients with Type 2 Diabetes Receiving Insulin Therapy
Min Kyeong Kim, Hye Seung Jung, Soo Heon Kwak, Young Min Cho, Kyong Soo Park, Seong Yeon Kim Endocrinology and Metabolism.2016; 31(2): 284. CrossRef - Severe Hypoglycemia and Cardiovascular or All-Cause Mortality in Patients with Type 2 Diabetes
Seon-Ah Cha, Jae-Seung Yun, Tae-Seok Lim, Seawon Hwang, Eun-Jung Yim, Ki-Ho Song, Ki-Dong Yoo, Yong-Moon Park, Yu-Bae Ahn, Seung-Hyun Ko Diabetes & Metabolism Journal.2016; 40(3): 202. CrossRef - Hypoglycemia and Health Costs
Yong-ho Lee, Gyuri Kim, Eun Seok Kang The Journal of Korean Diabetes.2016; 17(1): 11. CrossRef - Bi‐directional interaction between hypoglycaemia and cognitive impairment in elderly patients treated with glucose‐lowering agents: a systematic review and meta‐analysis
K. Mattishent, Y. K. Loke Diabetes, Obesity and Metabolism.2016; 18(2): 135. CrossRef - Trend of antihyperglycaemic therapy and glycaemic control in 184,864 adults with type 1 or 2 diabetes between 2002 and 2014: Analysis of real-life data from the DPV registry from Germany and Austria
Barbara Bohn, Wolfgang Kerner, Jochen Seufert, Hans-Peter Kempe, Peter M. Jehle, Frank Best, Martin Füchtenbusch, Andreas Knauerhase, Martin Hofer, Joachim Rosenbauer, Reinhard W. Holl Diabetes Research and Clinical Practice.2016; 115: 31. CrossRef - Characteristics of Hypoglycemia Pateints Visiting the Emergency Department of a University Hospital
Sang-Hyeon Choi, Deok-Ki Youn, Moon-Gi Choi, Ohk-Hyun Ryu The Journal of Korean Diabetes.2016; 17(3): 202. CrossRef - Increasing trend in emergency department visits for hypoglycemia from patients with type 2 diabetes mellitus in Taiwan
Ying-Ju Chen, Chen-Chang Yang, Lynn-Chu Huang, Likwang Chen, Chii-Min Hwu Primary Care Diabetes.2015; 9(6): 490. CrossRef - Intensive Individualized Reinforcement Education Is Important for the Prevention of Hypoglycemia in Patients with Type 2 Diabetes
Yun-Mi Yong, Kyung-Mi Shin, Kang-Min Lee, Jae-Young Cho, Sun-Hye Ko, Min-Hyang Yoon, Tae-Won Kim, Jong-Hyun Jeong, Yong-Moon Park, Seung-Hyun Ko, Yu-Bae Ahn Diabetes & Metabolism Journal.2015; 39(2): 154. CrossRef - 1,5-Anhydroglucitol as a Useful Marker for Assessing Short-Term Glycemic Excursions in Type 1 Diabetes
Hannah Seok, Ji Hye Huh, Hyun Min Kim, Byung-Wan Lee, Eun Seok Kang, Hyun Chul Lee, Bong Soo Cha Diabetes & Metabolism Journal.2015; 39(2): 164. CrossRef - A nationwide population-based study on the risk of coma, ketoacidosis and hypoglycemia in patients with celiac disease and type 1 diabetes
Matthew Kurien, Kaziwe Mollazadegan, David S. Sanders, Jonas F. Ludvigsson Acta Diabetologica.2015; 52(6): 1167. CrossRef - Blood electrolyte disturbances during severe hypoglycemia in Korean patients with type 2 diabetes
Mi Yeon Kang The Korean Journal of Internal Medicine.2015; 30(5): 648. CrossRef - Cardiovascular Disease Predicts Severe Hypoglycemia in Patients with Type 2 Diabetes
Jae-Seung Yun, Seung-Hyun Ko, Sun-Hye Ko, Ki-Ho Song, Ki-Dong Yoo, Kun-Ho Yoon, Yong-Moon Park, Yu-Bae Ahn Diabetes & Metabolism Journal.2015; 39(6): 498. CrossRef - The Influence of Admission Hypoglycemia on Clinical Outcomes in Acute Myocardial Infarction Patients with Diabetes Mellitus
Eun Jung Kim, Myung Ho Jeong, In Seok Jeong, Sang Gi Oh, Sang Hyung Kim, Young keun Ahn, Ju Han Kim, Young Jo Kim, Shung Chull Chae, Taek Jong Hong, In Whan Seong, Jei Keon Chae, Chong Jin Kim, Myeong Chan Cho, Ki Bae Seung, Hyo Soo Kim Korean Journal of Medicine.2014; 87(5): 565. CrossRef - Corrected QT Interval Prolongation during Severe Hypoglycemia without Hypokalemia in Patients with Type 2 Diabetes
Jae Won Beom, Jung Min Kim, Eun Joo Chung, Ju Yeong Kim, Seung Yeong Ko, Sang Don Na, Cheol Hwan Kim, Gun Park, Mi Yeon Kang Diabetes & Metabolism Journal.2013; 37(3): 190. CrossRef - Presence of Macroalbuminuria Predicts Severe Hypoglycemia in Patients With Type 2 Diabetes
Jae-Seung Yun, Sun-Hye Ko, Sun-Hee Ko, Ki-Ho Song, Yu-Bae Ahn, Kun-Ho Yoon, Yong-Moon Park, Seung-Hyun Ko Diabetes Care.2013; 36(5): 1283. CrossRef - Severe Hypoglycemia in Patients with Diabetes
Jae Seung Yun, Seung-Hyun Ko Diabetes & Metabolism Journal.2012; 36(4): 273. CrossRef - Severe hypoglycaemia requiring the assistance of emergency medical services - frequency, causes and symptoms
Veronika Krnacova, Ales Kubena, Karel Macek, Martin Bezdek, Alena Smahelova, Jiri Vlcek Biomedical Papers.2012; 156(3): 271. CrossRef - Higher Morning to Evening Ratio in Total Dose of Twice-Daily Biphasic Insulin Analog Might Be Effective in Achieving Glucose Control in Patients with Poorly Controlled Type 2 Diabetes
Yong-Ho Lee, Byung-Wan Lee, Hea Jin Kwon, Eun Seok Kang, Bong Soo Cha, Hyun Chul Lee Diabetes Technology & Therapeutics.2012; 14(6): 508. CrossRef
- A Survey on Ubiquitous Healthcare Service Demand among Diabetic Patients
-
Soo Lim, So-Youn Kim, Jung Im Kim, Min Kyung Kwon, Sei Jin Min, Soo Young Yoo, Seon Mee Kang, Hong Il Kim, Hye Seung Jung, Kyong Soo Park, Jun Oh Ryu, Hayley Shin, Hak Chul Jang
-
Diabetes Metab J. 2011;35(1):50-57. Published online February 28, 2011
-
DOI: https://doi.org/10.4093/dmj.2011.35.1.50
-
-
7,389
View
-
31
Download
-
23
Crossref
-
Abstract
PDFPubReader
- Background
Advanced information technology can be used when developing diagnostic and treatment strategies to provide better care for diabetic patients. However, the levels of need and demand for the use of technological advances have not been investigated in diabetic patients. We proposed and developed an individualized, ubiquitous (U)-healthcare service using advanced information technology for more effective glucose control. Prior to our service initiation, we surveyed patient needs and other pertinent information. MethodsDuring August 2009, we conducted a 34-item questionnaire survey among patients with diabetes who were older than 40 years in two certain hospitals in Korea. ResultsThe mean age of the 228 participants was 61.2±9 years, and males made up 49.1% of the sample. Seventy-one percent replied that they wanted individualized healthcare service, and they also wanted their health information to be delivered through mobile devices such as a cellular phone or a personal digital assistant (40.4%). Most patients had never heard of U-healthcare services (81.1%); however, after explaining the concept, 71.1% of participants responded that they would use the service if it was provided. Despite their willingness, participants were concerned about technical difficulty in using the service (26.3%) as well as the cost of the service (29.8%). ConclusionThe current study suggests that more than 70% of diabetic patients are interested in using U-healthcare services. To encourage widespread use, the application program or device of U-healthcare services should be simple, easy to use and affordable while also including a policy for the protection of private information.
-
Citations
Citations to this article as recorded by
- Willingness of diabetes mellitus patients to use mHealth applications and its associated factors for self-care management in a low-income country: an input for digital health implementation
Agmasie Damtew Walle, Tigist Andargie Ferede, Adamu Ambachew Shibabaw, Sisay Maru Wubante, Habtamu Alganeh Guadie, Chalachew Msganaw Yehula, Addisalem Workie Demsash BMJ Health & Care Informatics.2023; 30(1): e100761. CrossRef - Development and Operation of a Video Teleconsultation System Using Integrated Medical Equipment Gateway: a National Project for Workers in Underserved Areas
Hyun Sang Park, Kwang il Kim, Jae Young Soh, Young Ho Hyun, Bang Eun Lee, Jong Hwa Lee, Jung Gwon Jo, Han Chae Lee, Hwa Sun Kim Journal of Medical Systems.2020;[Epub] CrossRef - Patient experience with an educational mobile health application: A pilot study on usability and feasibility in a Saudi population
Sireen Abdul Rahim Shilbayeh, Sahar Abd El Rahman Ismail, Meihua Qian Cogent Psychology.2020;[Epub] CrossRef - Smart Care Based on Telemonitoring and Telemedicine for Type 2 Diabetes Care: Multi-Center Randomized Controlled Trial
Ji Yun Jeong, Jae-Han Jeon, Kwi-Hyun Bae, Yeon-Kyung Choi, Keun-Gyu Park, Jung-Guk Kim, Kyu Chang Won, Bong Soo Cha, Chul Woo Ahn, Dong Won Kim, Chang Hee Lee, In-Kyu Lee Telemedicine and e-Health.2018; 24(8): 604. CrossRef - Satisfaction Survey on Information Technology-Based Glucose Monitoring System Targeting Diabetes Mellitus in Private Local Clinics in Korea
Hun-Sung Kim, So Jung Yang, Yoo Jin Jeong, Young-Eun Kim, Seok-Won Hong, Jae Hyoung Cho Diabetes & Metabolism Journal.2017; 41(3): 213. CrossRef - Willingness of patients with diabetes to use an ICT-based self-management tool: a cross-sectional study
Tomomi Shibuta, Kayo Waki, Nobuko Tomizawa, Ayumi Igarashi, Noriko Yamamoto-Mitani, Satoko Yamaguchi, Hideo Fujita, Shigeko Kimura, Katsuhito Fujiu, Hironori Waki, Yoshihiko Izumida, Takayoshi Sasako, Masatoshi Kobayashi, Ryo Suzuki, Toshimasa Yamauchi, T BMJ Open Diabetes Research & Care.2017; 5(1): e000322. CrossRef - Evaluating the Effect of Web-Based Iranian Diabetic Personal Health Record App on Self-Care Status and Clinical Indicators: Randomized Controlled Trial
Amirabbas Azizi, Robab Aboutorabi, Zahra Mazloum-Khorasani, Monavar Afzal-Aghaea, Hamed Tabesh, Mahmood Tara JMIR Medical Informatics.2016; 4(4): e32. CrossRef - Development, Validation, and Evaluation of Web-Based Iranian Diabetic Personal Health Record: Rationale for and Protocol of a Randomized Controlled Trial
Amirabbas Azizi, Robab Aboutorabi, Zahra Mazloum-Khorasani, Monavar Afzal-Aghaea, Mahmood Tara JMIR Research Protocols.2016; 5(1): e39. CrossRef - Randomized, Open-Label, Parallel Group Study to Evaluate the Effect of Internet-Based Glucose Management System on Subjects with Diabetes in China
Hun-Sung Kim, Chenglin Sun, So Jung Yang, Lin Sun, Fei Li, In Young Choi, Jae-Hyoung Cho, Guixia Wang, Kun-Ho Yoon Telemedicine and e-Health.2016; 22(8): 666. CrossRef - Environment and Its Influence on Health and Demographics in South Korea
Ramiro Bravo Santisteban, Young Kim, Umar Farooq, Tae-Seong Kim, Sekyoung Youm, Seung-Hun Park International Journal of Environmental Research and Public Health.2016; 13(2): 183. CrossRef - U-Healthcare Center Service in Busan City, South Korea: An Empirical Analysis and the Results of 1 Year of Service
Ramiro D. Bravo Santisteban, Sekyoung Youm, Seung-Hun Park Telemedicine and e-Health.2015; 21(10): 774. CrossRef - Users’ perception on telemedicine service: a comparative study of public healthcare and private healthcare
Mi Jung Rho, Kun Ho Yoon, Hun-Sung Kim, In Young Choi Multimedia Tools and Applications.2015; 74(7): 2483. CrossRef - An Activity Recognition Model Using Inertial Sensor Nodes in a Wireless Sensor Network for Frozen Shoulder Rehabilitation Exercises
Hsueh-Chun Lin, Shu-Yin Chiang, Kai Lee, Yao-Chiang Kan Sensors.2015; 15(1): 2181. CrossRef - Current Clinical Status of Telehealth in Korea: Categories, Scientific Basis, and Obstacles
Hun-Sung Kim, Hyunah Kim, Suehyun Lee, Kye Hwa Lee, Ju Han Kim Healthcare Informatics Research.2015; 21(4): 244. CrossRef - New Directions in Chronic Disease Management
Hun-Sung Kim, Jae-Hyoung Cho, Kun-Ho Yoon Endocrinology and Metabolism.2015; 30(2): 159. CrossRef - Using mobile phones in healthcare management for the elderly
Hun-Sung Kim, Kye-Hwa Lee, Hyunah Kim, Ju Han Kim Maturitas.2014; 79(4): 381. CrossRef - Future Prospects of Health Management Systems Using Cellular Phones
Hun-Sung Kim, Yunji Hwang, Jae-Ho Lee, Hye Young Oh, Yi-Jun Kim, Hyeon Yoon Kwon, Hyoseung Kang, Hyunah Kim, Rae Woong Park, Ju Han Kim Telemedicine and e-Health.2014; 20(6): 544. CrossRef - Exploring the Relationship Among User Satisfaction, Compliance, and Clinical Outcomes of Telemedicine Services for Glucose Control
Mi Jung Rho, Si Ra Kim, Hun-Sung Kim, Jae-Hyoung Cho, Kun-Ho Yoon, Seong K. Mun, In Young Choi Telemedicine and e-Health.2014; 20(8): 712. CrossRef - Impact of Information Technology on the Therapy of Type-1 Diabetes: A Case Study of Children and Adolescents in Germany
Rolf-Dietrich Berndt, Claude Takenga, Petra Preik, Sebastian Kuehn, Luise Berndt, Herbert Mayer, Alexander Kaps, Ralf Schiel Journal of Personalized Medicine.2014; 4(2): 200. CrossRef - Perception of Influencing Factors on Acceptance of Mobile Health Monitoring Service: A Comparison between Users and Non-users
Jaebeom Lee, Mi Jung Rho Healthcare Informatics Research.2013; 19(3): 167. CrossRef - Telerehabilitation Needs: A Bidirectional Survey of Health Professionals and Individuals with Spinal Cord Injury in South Korea
Jongbae Kim, Shinyoung Lim, Jayeon Yun, Da-hye Kim Telemedicine and e-Health.2012; 18(9): 713. CrossRef - Development of a smartphone-based diabetes self-care management system
Sang Youl Rhee, Jeong-taek Woo, Young Seol Kim, Young Kil Choi Personalized Medicine Universe.2012; 1(1): 85. CrossRef - Features of Mobile Diabetes Applications: Review of the Literature and Analysis of Current Applications Compared Against Evidence-Based Guidelines
Taridzo Chomutare, Luis Fernandez-Luque, Eirik Årsand, Gunnar Hartvigsen Journal of Medical Internet Research.2011; 13(3): e65. CrossRef
- Type 1 Diabetes
- In Vivo Differentiation of Endogenous Bone Marrow-Derived Cells into Insulin-Producing Cells Using Four Soluble Factors
-
Seung-Ah Lee, Subin Kim, Seog-Young Kim, Jong Yoen Park, Hye Seung Jung, Sung Soo Chung, Kyong Soo Park
-
Received April 2, 2024 Accepted June 17, 2024 Published online October 24, 2024
-
DOI: https://doi.org/10.4093/dmj.2024.0174
[Epub ahead of print]
-
-
Abstract
PDFSupplementary MaterialPubReader ePub
- Four soluble factors—putrescine, glucosamine, nicotinamide, and signal transducer and activator of transcription 3 (STAT3) inhibitor BP-1-102—were shown to differentiate bone marrow mononucleated cells (BMNCs) into functional insulin-producing cells (IPCs) in vitro. Transplantation of these IPCs improved hyperglycemia in diabetic mice. However, the role of endogenous BMNC regeneration in this effect was unclear. This study aimed to evaluate the effect of these factors on in vivo BMNC differentiation into IPCs in diabetic mice. Mice were orally administered the factors for 5 days, twice at 2-week intervals, and monitored for 45–55 days. Glucose tolerance, glucose-stimulated insulin secretion, and pancreatic insulin content were measured. Chimeric mice harboring BMNCs from insulin promoter luciferase/green fluorescent protein (GFP) transgenic mice were used to track endogenous BMNC fate. These factors lowered blood glucose levels, improved glucose tolerance, and enhanced insulin secretion. Immunostaining confirmed IPCs in the pancreas, showing the potential of these factors to induce β-cell regeneration and improve diabetes treatment.
|