- Metabolic Risk/Epidemiology
- Maternal Hyperglycemia during Pregnancy Increases Adiposity of Offspring
-
Hye Rim Chung, Joon Ho Moon, Jung Sub Lim, Young Ah Lee, Choong Ho Shin, Joon-Seok Hong, Soo Heon Kwak, Sung Hee Choi, Hak Chul Jang
-
Diabetes Metab J. 2021;45(5):730-738. Published online February 22, 2021
-
DOI: https://doi.org/10.4093/dmj.2020.0154
-
-
6,942
View
-
201
Download
-
11
Web of Science
-
10
Crossref
-
Graphical Abstract
Abstract
PDF Supplementary Material PubReader ePub

- Background
The effect of intrauterine hyperglycemia on fat mass and regional fat proportion of the offspring of mothers with gestational diabetes mellitus (OGDM) remains to be determined.
Methods The body composition of OGDM (n=25) and offspring of normoglycemic mothers (n=49) was compared using dualenergy X-ray absorptiometry at age 5 years. The relationship between maternal glucose concentration during a 100 g oral glucose tolerance test (OGTT) and regional fat mass or proportion was analyzed after adjusting for maternal prepregnancy body mass index (BMI).
Results BMI was comparable between OGDM and control (median, 16.0 kg/m2 vs. 16.1 kg/m2 ). Total, truncal, and leg fat mass were higher in OGDM compared with control (3,769 g vs. 2,245 g, P=0.004; 1,289 g vs. 870 g, P=0.017; 1,638 g vs. 961 g, P=0.002, respectively), whereas total lean mass was lower in OGDM (15,688 g vs. 16,941 g, P=0.001). Among OGDM, total and truncal fat mass were correlated with fasting and 3-hour glucose concentrations of maternal 100 g OGTT during pregnancy (total fat mass, r=0.49, P=0.018 [fasting], r=0.473, P=0.023 [3-hour]; truncal fat mass, r=0.571, P=0.004 [fasting], r=0.558, P=0.006 [3-hour]), but there was no correlation between OGDM leg fat mass and maternal OGTT during pregnancy. Regional fat indices were not correlated with concurrent maternal 75 g OGTT values.
Conclusion Intrauterine hyperglycemia is associated with increased fat mass, especially truncal fat, in OGDM aged 5 years.
-
Citations
Citations to this article as recorded by 
- Maternal high-fat diet programs offspring airway hyperinnervation and hyperresponsiveness
Kayla R. Williams, Hoyt A.T.K. Bright, Allison D. Fryer, David B. Jacoby, Zhenying Nie JCI Insight.2025;[Epub] CrossRef - Advances in free fatty acid profiles in gestational diabetes mellitus
Haoyi Du, Danyang Li, Laura Monjowa Molive, Na Wu Journal of Translational Medicine.2024;[Epub] CrossRef - 2023 Clinical Practice Guidelines for Diabetes Management in Korea: Full Version Recommendation of the Korean Diabetes Association
Jun Sung Moon, Shinae Kang, Jong Han Choi, Kyung Ae Lee, Joon Ho Moon, Suk Chon, Dae Jung Kim, Hyun Jin Kim, Ji A Seo, Mee Kyoung Kim, Jeong Hyun Lim, Yoon Ju Song, Ye Seul Yang, Jae Hyeon Kim, You-Bin Lee, Junghyun Noh, Kyu Yeon Hur, Jong Suk Park, Sang Diabetes & Metabolism Journal.2024; 48(4): 546. CrossRef - Type 1 Diabetes and Pregnancy: Challenges in Glycemic Control and Maternal–Fetal Outcomes
Tejumola Apata, Dennis Samuel, Laticia Valle, Sarah D. Crimmins Seminars in Reproductive Medicine.2024; 42(03): 239. CrossRef - Association between serum free fatty acids and gestational diabetes mellitus
Danyang Li, Haoyi Du, Na Wu Frontiers in Endocrinology.2024;[Epub] CrossRef - High-fat diet during pregnancy lowers fetal weight and has a long-lasting adverse effect on brown adipose tissue in the offspring
Mihoko Yamaguchi, Jun Mori, Nozomi Nishida, Satoshi Miyagaki, Yasuhiro Kawabe, Takeshi Ota, Hidechika Morimoto, Yusuke Tsuma, Shota Fukuhara, Takehiro Ogata, Takuro Okamaura, Naoko Nakanishi, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Tomoko I Journal of Developmental Origins of Health and Disease.2023; 14(2): 261. CrossRef - Prediction of gestational diabetes mellitus in Asian women using machine learning algorithms
Byung Soo Kang, Seon Ui Lee, Subeen Hong, Sae Kyung Choi, Jae Eun Shin, Jeong Ha Wie, Yun Sung Jo, Yeon Hee Kim, Kicheol Kil, Yoo Hyun Chung, Kyunghoon Jung, Hanul Hong, In Yang Park, Hyun Sun Ko Scientific Reports.2023;[Epub] CrossRef - Effects of early standardized management on the growth trajectory of offspring with gestational diabetes mellitus at 0–5 years old: a preliminary longitudinal study
Bingbing Guo, Jingjing Pei, Yin Xu, Yajie Wang, Xinye Jiang Scientific Reports.2023;[Epub] CrossRef - Gestational Diabetes Mellitus: Diagnostic Approaches and Maternal-Offspring Complications
Joon Ho Moon, Hak Chul Jang Diabetes & Metabolism Journal.2022; 46(1): 3. CrossRef - Increased Pro-Inflammatory T Cells, Senescent T Cells, and Immune-Check Point Molecules in the Placentas of Patients With Gestational Diabetes Mellitus
Yea Eun Kang, Hyon-Seung Yi, Min-Kyung Yeo, Jung Tae Kim, Danbit Park, Yewon Jung, Ok Soon Kim, Seong Eun Lee, Ji Min Kim, Kyong Hye Joung, Ju Hee Lee, Bon Jeong Ku, Mina Lee, Hyun Jin Kim Journal of Korean Medical Science.2022;[Epub] CrossRef
- Clinical Care/Education
- Pregnancy Outcomes of Women Additionally Diagnosed as Gestational Diabetes by the International Association of the Diabetes and Pregnancy Study Groups Criteria
-
Min Hyoung Kim, Soo Heon Kwak, Sung-Hoon Kim, Joon Seok Hong, Hye Rim Chung, Sung Hee Choi, Moon Young Kim, Hak C. Jang
-
Diabetes Metab J. 2019;43(6):766-775. Published online February 28, 2019
-
DOI: https://doi.org/10.4093/dmj.2018.0192
-
-
7,457
View
-
110
Download
-
30
Web of Science
-
32
Crossref
-
Abstract
PDF PubReader
- Background
We investigated the pregnancy outcomes in women who were diagnosed with gestational diabetes mellitus (GDM) by the International Association of the Diabetes and Pregnancy Study Groups (IADPSG) criteria but not by the Carpenter-Coustan (CC) criteria. MethodsA total of 8,735 Korean pregnant women were identified at two hospitals between 2014 and 2016. Among them, 2,038 women participated in the prospective cohort to investigate pregnancy outcomes. Diagnosis of GDM was made via two-step approach with 50-g glucose challenge test for screening followed by diagnostic 2-hour 75-g oral glucose tolerance test. Women were divided into three groups: non-GDM, GDM diagnosed exclusively by the IADPSG criteria, and GDM diagnosed by the CC criteria. ResultsThe incidence of GDM was 2.1% according to the CC criteria, and 4.1% by the IADPSG criteria. Women diagnosed with GDM by the IADPSG criteria had a higher body mass index (22.0±3.1 kg/m2 vs. 21.0±2.8 kg/m2, P<0.001) and an increased risk of preeclampsia (odds ratio [OR], 6.90; 95% confidence interval [CI], 1.84 to 25.87; P=0.004) compared to non-GDM women. Compared to neonates of the non-GDM group, those of the IADPSG GDM group had an increased risk of being large for gestational age (OR, 2.39; 95% CI, 1.50 to 3.81; P<0.001), macrosomia (OR, 2.53; 95% CI, 1.26 to 5.10; P=0.009), and neonatal hypoglycemia (OR, 3.84; 95% CI, 1.01 to 14.74; P=0.049); they were also at an increased risk of requiring phototherapy (OR, 1.57; 95% CI, 1.07 to 2.31; P=0.022) compared to the non-GDM group. ConclusionThe IADPSG criteria increased the incidence of GDM by nearly three-fold, and women diagnosed with GDM by the IADPSG criteria had an increased risk of adverse pregnancy outcomes in Korea.
-
Citations
Citations to this article as recorded by 
- Gestational diabetes mellitus and adverse maternal and perinatal outcomes in twin and singleton pregnancies: a systematic review and meta-analysis
Elena Greco, Maria Calanducci, Kypros H. Nicolaides, Eleanor V.H. Barry, Mohammed S.B. Huda, Stamatina Iliodromiti American Journal of Obstetrics and Gynecology.2024; 230(2): 213. CrossRef - Neonatal outcomes according to different glucose threshold values in gestational diabetes: a register-based study
Kaisa Kariniemi, Marja Vääräsmäki, Tuija Männistö, Sanna Mustaniemi, Eero Kajantie, Sanna Eteläinen, Elina Keikkala, Anneli Pouta, Risto Kaaja, Johan G Eriksson, Hannele Laivuori, Mika Gissler BMC Pregnancy and Childbirth.2024;[Epub] CrossRef - The problem of diabetes mellitus in obstetrics
E.V. Popova-Petrosyan, A.A. Dovgan’, E.R. Kulieva Russian Bulletin of Obstetrician-Gynecologist.2024; 24(3): 25. CrossRef - 2023 Clinical Practice Guidelines for Diabetes Management in Korea: Full Version Recommendation of the Korean Diabetes Association
Jun Sung Moon, Shinae Kang, Jong Han Choi, Kyung Ae Lee, Joon Ho Moon, Suk Chon, Dae Jung Kim, Hyun Jin Kim, Ji A Seo, Mee Kyoung Kim, Jeong Hyun Lim, Yoon Ju Song, Ye Seul Yang, Jae Hyeon Kim, You-Bin Lee, Junghyun Noh, Kyu Yeon Hur, Jong Suk Park, Sang Diabetes & Metabolism Journal.2024; 48(4): 546. CrossRef - Association between gestational diabetes mellitus diagnostic criteria and adverse pregnancy outcomes—a systematic review and meta-analysis of adjusted effect sizes from studies using current diagnostic criteria
Elhassan Mahmoud, Abdalla Moustafa Elsayed, Basant Elsayed, Yasmin Elsalakawi, Aswathy Gopinath, Tawanda Chivese BMJ Open.2024; 14(11): e091258. CrossRef - Usefulness of Glycated Albumin Levels in Predicting the Maternal or Neonatal Complications of Gestational Diabetes Mellitus during Late Pregnancy in South Korea: A Retrospective Study
Jihan Kim, Sami Lee, Jong Sung Kim Korean Journal of Family Medicine.2024;[Epub] CrossRef - Pregnancy complications in women with pregestational and gestational diabetes mellitus
Lukas Reitzle, Christin Heidemann, Jens Baumert, Matthias Kaltheuner, Heinke Adamczewski, Andrea Icks, Christa Scheidt-Nave Deutsches Ärzteblatt international.2023;[Epub] CrossRef - Predicting the Risk of Insulin-Requiring Gestational Diabetes before Pregnancy: A Model Generated from a Nationwide Population-Based Cohort Study in Korea
Seung-Hwan Lee, Jin Yu, Kyungdo Han, Seung Woo Lee, Sang Youn You, Hun-Sung Kim, Jae-Hyoung Cho, Kun-Ho Yoon, Mee Kyoung Kim Endocrinology and Metabolism.2023; 38(1): 129. CrossRef - Treatment of women with mild gestational diabetes mellitus decreases the risk of adverse perinatal outcomes
Fanny Goyette, Bi Lan Wo, Marie-Hélène Iglesias, Evelyne Rey, Ariane Godbout Diabetes & Metabolism.2023; 49(4): 101458. CrossRef - Maternal and fetal outcomes of pregnancies associated with single versus double abnormal values in 100 gr glucose tolerance test
Mohammadali Shahriari, Ali Shahriari, Maryam Khooshideh, Anahita Dehghaninezhad, Arezoo Maleki-Hajiagha, Rana Karimi Journal of Diabetes & Metabolic Disorders.2023; 22(2): 1347. CrossRef - Diagnosis and management of gestational diabetes mellitus
Tae Jung Oh Journal of the Korean Medical Association.2023; 66(7): 414. CrossRef - Update on gestational diabetes and adverse pregnancy outcomes
Bryan Ugwudike, ManHo Kwok Current Opinion in Obstetrics & Gynecology.2023; 35(5): 453. CrossRef - Effects of early standardized management on the growth trajectory of offspring with gestational diabetes mellitus at 0–5 years old: a preliminary longitudinal study
Bingbing Guo, Jingjing Pei, Yin Xu, Yajie Wang, Xinye Jiang Scientific Reports.2023;[Epub] CrossRef - Can Triglyceride/Glucose Index (TyG) and Triglyceride/HDL-Cholesterol Ratio (TG/HDL-c) Predict Gestational Diabetes Mellitus?
Seval YILMAZ ERGANİ, Tolgay Tuyan İLHAN, Betül TOKGÖZ, Burak BAYRAKTAR, Mevlüt BUCAK, Müjde Can İBANOĞLU, Kadriye YAKUT YÜCEL, Kadriye ERDOĞAN, Cantekin İSKENDER, Yaprak ÜSTÜN Ankara Eğitim ve Araştırma Hastanesi Tıp Dergisi.2023; 56(2): 117. CrossRef - Risk factors for postpartum urinary incontinence: The impact of early-onset and late-onset Gestational Diabetes Mellitus in a nested case-control study
Carlos I. Sartorão Filho, Fabiane A. Pinheiro, Luiz Takano, Caroline B. Prudêncio, Sthefanie K. Nunes, Hallur RLS, Iracema M.P. Calderon, Angélica M.P. Barbosa, Marilza V.C. Rudge European Journal of Obstetrics & Gynecology and Reproductive Biology.2023; 290: 5. CrossRef - Review of the Screening Guidelines for Gestational Diabetes Mellitus: How to Choose Wisely
Ravleen Kaur Bakshi, Akshay Kumar, Vandana Gupta, A.G. Radhika, Puneet Misra, Pankaj Bhardwaj Indian Journal of Community Medicine.2023; 48(6): 828. CrossRef - Postprandial Free Fatty Acids at Mid-Pregnancy Increase the Risk of Large-for-Gestational-Age Newborns in Women with Gestational Diabetes Mellitus
So-Yeon Kim, Young Shin Song, Soo-Kyung Kim, Yong-Wook Cho, Kyung-Soo Kim Diabetes & Metabolism Journal.2022; 46(1): 140. CrossRef - Gestational Diabetes Mellitus: Diagnostic Approaches and Maternal-Offspring Complications
Joon Ho Moon, Hak Chul Jang Diabetes & Metabolism Journal.2022; 46(1): 3. CrossRef - Risk and Risk Factors for Postpartum Type 2 Diabetes Mellitus in Women with Gestational Diabetes: A Korean Nationwide Cohort Study
Mi Jin Choi, Jimi Choi, Chae Weon Chung Endocrinology and Metabolism.2022; 37(1): 112. CrossRef - Gestational diabetes mellitus: current screening problems
N. I. Volkova, S. O. Panenko Diabetes mellitus.2022; 25(1): 72. CrossRef - Gestational diabetes mellitus and adverse pregnancy outcomes: systematic review and meta-analysis
Wenrui Ye, Cong Luo, Jing Huang, Chenglong Li, Zhixiong Liu, Fangkun Liu BMJ.2022; : e067946. CrossRef - Effect of Different Types of Diagnostic Criteria for Gestational Diabetes Mellitus on Adverse Neonatal Outcomes: A Systematic Review, Meta-Analysis, and Meta-Regression
Fahimeh Ramezani Tehrani, Marzieh Saei Ghare Naz, Razieh Bidhendi-Yarandi, Samira Behboudi-Gandevani Diabetes & Metabolism Journal.2022; 46(4): 605. CrossRef - Triglyceride and glucose index and the risk of gestational diabetes mellitus: A nationwide population-based cohort study
Jung A Kim, Jinsil Kim, Eun Roh, So-hyeon Hong, You-Bin Lee, Sei Hyun Baik, Kyung Mook Choi, Eunjin Noh, Soon Young Hwang, Geum Joon Cho, Hye Jin Yoo Diabetes Research and Clinical Practice.2021; 171: 108533. CrossRef - Effect of the IADPSG screening strategy for gestational diabetes on perinatal outcomes in Switzerland
Evelyne M. Aubry, Luigi Raio, Stephan Oelhafen Diabetes Research and Clinical Practice.2021; 175: 108830. CrossRef - Estimated impact of introduction of new diagnostic criteria for gestational diabetes mellitus
Leon de Wit, Anna B Zijlmans, Doortje Rademaker, Christiana A Naaktgeboren, J Hans DeVries, Arie Franx, Rebecca C Painter, Bas B van Rijn World Journal of Diabetes.2021; 12(6): 868. CrossRef - The Clinical Characteristics of Gestational Diabetes Mellitus in Korea: A National Health Information Database Study
Kyung-Soo Kim, Sangmo Hong, Kyungdo Han, Cheol-Young Park Endocrinology and Metabolism.2021; 36(3): 628. CrossRef - Fetal Abdominal Obesity Detected At 24 to 28 Weeks of Gestation Persists Until Delivery Despite Management of Gestational Diabetes Mellitus
Wonjin Kim, Soo Kyung Park, Yoo Lee Kim Diabetes & Metabolism Journal.2021; 45(4): 547. CrossRef - Nonalcoholic fatty liver disease and the risk of insulin-requiring gestational diabetes
Sang Youn You, Kyungdo Han, Seung-Hawn Lee, Mee Kyoung Kim Diabetology & Metabolic Syndrome.2021;[Epub] CrossRef - Maternal Hyperglycemia during Pregnancy Increases Adiposity of Offspring
Hye Rim Chung, Joon Ho Moon, Jung Sub Lim, Young Ah Lee, Choong Ho Shin, Joon-Seok Hong, Soo Heon Kwak, Sung Hee Choi, Hak Chul Jang Diabetes & Metabolism Journal.2021; 45(5): 730. CrossRef - Prepregnancy smoking and the risk of gestational diabetes requiring insulin therapy
Mee Kyoung Kim, Kyungdo Han, Sang Youn You, Hyuk-Sang Kwon, Kun-Ho Yoon, Seung-Hwan Lee Scientific Reports.2020;[Epub] CrossRef - Gestational Diabetes Mellitus: Diagnosis and Glycemic Control
Tae Jung Oh, Hak Chul Jang The Journal of Korean Diabetes.2020; 21(2): 69. CrossRef - New Diagnostic Criteria for Gestational Diabetes Mellitus and Pregnancy Outcomes in Korea
Kyu Yeon Hur Diabetes & Metabolism Journal.2019; 43(6): 763. CrossRef
|