- Metabolic Risk/Epidemiology
- The Association between Pulmonary Functions and Incident Diabetes: Longitudinal Analysis from the Ansung Cohort in Korea
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Hoon Sung Choi, Sung Woo Lee, Jin Taek Kim, Hong Kyu Lee
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Diabetes Metab J. 2020;44(5):699-710. Published online April 16, 2020
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DOI: https://doi.org/10.4093/dmj.2019.0109
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Abstract
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Background
We sought to explore whether reduced pulmonary function is an independent risk factor for incident diabetes in Koreans.
Methods
We conducted a prospective cohort study of pulmonary function as a risk factor for incident diabetes using 10-year follow-up data from 3,864 middle-aged adults from the Ansung cohort study in Korea. The incidence of diabetes was assessed using both oral glucose tolerance tests and glycosylated hemoglobin levels.
Results
During 37,118 person-years of follow-up, 583 participants developed diabetes (incidence rate: 15.7 per 1,000 person-years). The mean follow-up period was 8.0±3.7 years. Forced vital capacity (FVC; % predicted) and forced expiratory volume in 1 second (FEV1; % predicted) were significantly correlated with incident diabetes in a graded manner after adjustment for sex, age, smoking, exercise, and metabolic parameters. The adjusted hazard ratio (HR) and confidence interval (CI) for diabetes were 1.408 (1.106 to 1.792) and 1.469 (1.137 to 1.897) in the first quartiles of FVC and FEV1, respectively, when compared with the highest quartile. Furthermore, the FVC of the lowest first and second quartiles showed a significantly higher 10-year panel homeostasis model assessment of insulin resistance index, with differences of 0.095 (95% CI, 0.010 to 0.018; P=0.028) and 0.127 (95% CI, 0.044 to 0.210; P=0.003), respectively, when compared to the highest quartiles.
Conclusion
FVC and FEV1 are independent risk factors for developing diabetes in Koreans. Pulmonary factors are possible risk factors for insulin resistance and diabetes.
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Citations
Citations to this article as recorded by
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Feng Zhang, Cunjian Bi, Xiaojian Yin, Yuan Liu, Yaru Guo, Pengwei Sun, Jun Hong, Yanyan Hu BMC Public Health.2024;[Epub] CrossRef - Relationships among Dioxin-like Mitochondria Inhibitor Substances (MIS)-Mediated Mitochondria Dysfunction, Obesity, and Lung Function in a Korean Cohort
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