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Hirofumi Kai  (Kai H) 1 Article
The Role of Heat Shock Response in Insulin Resistance and Diabetes
Tatsuya Kondo, Hiroyuki Motoshima, Motoyuki Igata, Junji Kawashima, Takeshi Matsumura, Hirofumi Kai, Eiichi Araki
Diabetes Metab J. 2014;38(2):100-106.   Published online April 18, 2014
DOI: https://doi.org/10.4093/dmj.2014.38.2.100
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  • 7 Web of Science
  • 10 Crossref
AbstractAbstract PDFPubReader   

The expansion of life-style related diseases, such as metabolic syndrome (MS) and type 2 diabetes mellitus (T2DM), appears to be unstoppable. It is also difficult to cease their complications in spite of many antidiabetic medications or intervention of public administration. We and our collaborators found that physical medicine using simultaneous stimulation of heat with mild electric current activates heat shock response, thereby reducing visceral adiposity, insulin resistance, chronic inflammation and improving glucose homeostasis in mice models of T2DM, as well as in humans with MS or T2DM. This combination therapy exerts novel action on insulin signaling, β-cell protection and body compositions, and may provide a new therapeutic alternative in diabetic treatment strategy.

Citations

Citations to this article as recorded by  
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    Current Hypertension Reports.2016;[Epub]     CrossRef
  • αB-crystallin and HspB2 deficiency is protective from diet-induced glucose intolerance
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    Genomics Data.2016; 9: 10.     CrossRef
  • DNAJB3/HSP-40 cochaperone improves insulin signaling and enhances glucose uptake in vitro through JNK repression
    Mohamed Abu-Farha, Preethi Cherian, Irina Al-Khairi, Ali Tiss, Abdelkrim Khadir, Sina Kavalakatt, Samia Warsame, Mohammed Dehbi, Kazem Behbehani, Jehad Abubaker
    Scientific Reports.2015;[Epub]     CrossRef
  • Reduced nuclear protein 1 expression improves insulin sensitivity and protects against diet-induced glucose intolerance through up-regulation of heat shock protein 70
    H.C. Barbosa-Sampaio, R. Drynda, B. Liu, A.M. Rodriguez De Ledesma, C. Malicet, J.L. Iovanna, P.M. Jones, D.S. Muller, S.J. Persaud
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    PLoS ONE.2014; 9(12): e114690.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal