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Hee-Jung Kim  (Kim HJ) 1 Article
ENPP1 K121Q Genotype Not Associated with Coronary Artery Calcification in Korean Patients with Type 2 Diabetes Mellitus
Dae Joon Jeong, Dong Gyu Lee, Hee-Jung Kim, Eun Hee Cho, Sang-Wook Kim
Korean Diabetes J. 2010;34(5):320-326.   Published online October 31, 2010
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AbstractAbstract PDFPubReader   

Ectonucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) generates inorganic pyrophosphate, a solute that serves as an essential physiological inhibitor of calcification. Inactivating mutations of ENPP1 are associated with generalized calcification in infancy and an increased risk of developing type 2 diabetes mellitus (T2DM). We hypothesized that the ENPP1 K121Q variant may be associated with increased coronary artery calcification in T2DM patients.


The study subjects were aged 34 to 85 years and showed no evidence of clinical cardiovascular disease prior to recruitment. A total of 140 patients with T2DM were assessed for their coronary artery calcium (CAC) scores and ENPP1 K121Q polymorphisms were identified.


The prevalence of subjects carrying the KQ genotype was 12.9% (n = 18). There were no 121QQ homozygotes. Patients with the KQ genotype did not show a significantly higher CAC score (122 vs. 18; P = 0.858). We matched each patient with the KQ genotype to a respective control with the KK genotype by gender, age, and duration of diabetes. When compared to matched controls, we observed no significant difference in CAC score (P = 0.959).


The ENPP1 K121Q polymorphism does not appear to be associated with coronary artery calcification in patients with T2DM.


Citations to this article as recorded by  
  • Evaluation of NPP1 as a Novel Biomarker of Coronary Artery Disease: A Pilot Study in Human Beings
    Amir Hooshang Mohammadpour, Saeed Nazemi, Fatemeh Mashhadi, Atefeh Rezapour, Mohammad Afshar, Sepideh Afzalnia, Afsaneh Mohammadi, Hamid Reza Mashreghi Moghadam, Maryam Moradian, Seyed Mohammad Hasan Moallem, Saeed Falahaty, Azadeh Zayerzadeh, Sepideh Ely
    Advanced Pharmaceutical Bulletin.2018; 8(3): 489.     CrossRef
  • ENPP1 121Q functional variant enhances susceptibility to coronary artery disease in South Indian patients with type 2 diabetes mellitus
    S. Sumi, Surya Ramachandran, V RamanKutty, Maulin M. Patel, T. N. Anand, Ajit S Mullasari, C. C. Kartha
    Molecular and Cellular Biochemistry.2017; 435(1-2): 67.     CrossRef
  • Genetics in Arterial Calcification
    Frank Rutsch, Yvonne Nitschke, Robert Terkeltaub, Dwight A. Towler
    Circulation Research.2011; 109(5): 578.     CrossRef
  • Distribution of allelic variants of genes inhibitors and activators ectopic calcification in patients with acute coronary syndrome
    V. Yu. Harbuzova, O. A. Obukhova, I. O. Rozumenko, Ye. I. Dubovyk, T. M. Oleshko, Ye. A. Harbuzova, D. V. Shvachko, O. V. Ataman
    Faktori eksperimental'noi evolucii organizmiv.1970; 21: 306.     CrossRef

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