- Metabolic Risk/Epidemiology
- Metabolic Health, Obesity, and the Risk of Developing Open-Angle Glaucoma: Metabolically Healthy Obese Patients versus Metabolically Unhealthy but Normal Weight Patients
-
Younhea Jung, Kyungdo Han, Hae-Young L. Park, Seung Hoon Lee, Chan Kee Park
-
Diabetes Metab J. 2020;44(3):414-425. Published online December 23, 2019
-
DOI: https://doi.org/10.4093/dmj.2019.0048
-
-
8,228
View
-
141
Download
-
41
Web of Science
-
49
Crossref
-
Abstract
PDFPubReader
- Background
This study sought to investigate the associations between metabolic health status, obesity, and incidence of primary open-angle glaucoma (POAG). MethodsIn this nationwide, population-based, longitudinal prospective cohort study conducted using the Korean National Health Insurance System, we categorized all subjects based on presence and severity of metabolic syndrome and obesity. Insurance claims data were used to identify POAG development. Then, Cox regression was applied to calculate the hazard of developing POAG in people with various components of metabolic syndrome, obesity, or their combination. ResultsOf the total 287,553 subjects, 4,970 (1.3%) developed POAG. High fasting glucose, blood pressure, and total cholesterol levels were all associated with increased risk of developing POAG. Regarding obesity level, people with body mass index (BMI) greater than 30 kg/m2 were more likely to develop POAG than those with normal BMI. Also, people with greater number of metabolic syndrome components showed a greater POAG incidence. People who are metabolically unhealthy and obese (adjusted hazard ratio [HR], 1.574; 95% confidence interval [CI], 1.449 to 1.711) and those who are metabolically unhealthy nonobese (MUNO: adjusted HR, 1.521; 95% CI, 1.405 to 1.645) but not those who are metabolically healthy obese (MHO: adjusted HR, 1.019; 95% CI, 0.907 to 1.144) had an increased hazard of developing POAG compared with metabolically healthy nonobese (MHNO) subjects. ConclusionMetabolic health status and obesity were significantly associated with increased risk of POAG incidence. MUNO subjects but not MHO subjects showed a higher risk of POAG development than did MHNO subjects, suggesting that metabolic status is more important than obesity in POAG.
-
Citations
Citations to this article as recorded by
- Risk of depression in glaucoma patients with vision impairment: A nationwide cohort study
Sheng-Min Wang, Younhea Jung, Kyungdo Han, Kyoung Ohn, Hae-young Lopilly Park, Chan Kee Park, Jung Il Moon Heliyon.2025; 11(1): e40617. CrossRef - The Association Between Intermittent Fasting and Glaucoma
Marlow Schulz, Leona Ding, Shu Feng, Andrew Chen, Philip P. Chen, Karine D. Bojikian Journal of Glaucoma.2025; 34(1): 1. CrossRef - The Association between the Gut Microbiota and Erectile Dysfunction
Tianle Zhu, Xi Liu, Peng Yang, Yukuai Ma, Pan Gao, Jingjing Gao, Hui Jiang, Xiansheng Zhang The World Journal of Men's Health.2024; 42(4): 772. CrossRef - Potentially compromised systemic and local lactate metabolic balance in glaucoma, which could increase retinal glucose and glutamate concentrations
Mina Arai-Okuda, Yusuke Murai, Hidetaka Maeda, Akiyasu Kanamori, Takako Miki, Tomoko Naito, Kazunobu Sugihara, Michihiro Kono, Masaki Tanito, Hiromitsu Onoe, Kazuyuki Hirooka, Yoshiaki Kiuchi, Masakazu Shinohara, Sentaro Kusuhara, Sotaro Mori, Kaori Ueda, Scientific Reports.2024;[Epub] CrossRef - Association between Glucagon-like Peptide-1 Receptor Agonists and the Risk of Glaucoma in Individuals with Type 2 Diabetes
Siar Niazi, Filip Gnesin, Anna-Sophie Thein, Jens R. Andreasen, Anna Horwitz, Zaynab A. Mouhammad, Baker N. Jawad, Zia Niazi, Nelsan Pourhadi, Bochra Zareini, Amani Meaidi, Christian Torp-Pedersen, Miriam Kolko Ophthalmology.2024; 131(9): 1056. CrossRef - The risk of open angle glaucoma in young adults with allergic diseases: a Nationwide cohort study
Kyungdo Han, Jin-Hyung Jung, Younhea Jung, Kyoung Ohn, Jung Il Moon Scientific Reports.2024;[Epub] CrossRef - The relationship of the metabolic syndrome and its correction with the development and progression of glaucoma
S. I. Makogon, D. I. Ivanova National Journal glaucoma.2024; 23(1): 65. CrossRef - Glaucoma and metabolic syndrome
A. M. Getmanova, A. Yu. Brezhnev, A. V. Kuroyedov, S. A. Zubasheva National Journal glaucoma.2024; 23(2): 107. CrossRef - Evaluating the impact of caloric restriction, body mass index and exercise on primary open-angle glaucoma: A review
Jonathan YM Lai, Patrick Mclarnon, Carl Sheridan, Neeru A Vallabh European Journal of Ophthalmology.2024;[Epub] CrossRef - Fecal microbiota transplantation for glaucoma; a potential emerging treatment strategy
Rasoul Ebrahimi, Yeganeh Farsi, Seyed Aria Nejadghaderi Current Research in Microbial Sciences.2024; 7: 100314. CrossRef - Estimates and trends in the global burden of glaucoma influenced by metabolic risk factors from Global Burden of Disease Study between 1990 to 2019
Juan Chen, Hua Fan, Qingwen Yu, Ting Tang, Xuhan Tong, Siqi Hu, Yao You, Shenghui Zhang, Chen Chen, Jiake Tang, Hu Wang, Xinyan Fu, Xingwei Zhang, Mingwei Wang, Yongran Cheng European Journal of Ophthalmology.2024;[Epub] CrossRef - Association of obesity and metabolic syndrome with incident primary open angle glaucoma in the UK Biobank
Carmelo Z. Macri, Christopher X. Wong, Samuel J. Tu, David F. Sun, Robert Casson, Kuldev Singh, Sophia Wang, Michelle T. Sun Clinical & Experimental Ophthalmology.2024;[Epub] CrossRef - Therapeutic Effects of Taurine and Histidine Supplementation in Retinal Diseases
Deokho Lee, Lois E. H. Smith Life.2024; 14(12): 1566. CrossRef - Candidate SNP Markers Significantly Altering the Affinity of the TATA-Binding Protein for the Promoters of Human Genes Associated with Primary Open-Angle Glaucoma
Karina Zolotareva, Polina A. Dotsenko, Nikolay Podkolodnyy, Roman Ivanov, Aelita-Luiza Makarova, Irina Chadaeva, Anton Bogomolov, Pavel S. Demenkov, Vladimir Ivanisenko, Dmitry Oshchepkov, Mikhail Ponomarenko International Journal of Molecular Sciences.2024; 25(23): 12802. CrossRef - Association Between Glycemic Traits and Primary Open-Angle Glaucoma: A Mendelian Randomization Study in the Japanese Population
Akiko Hanyuda, Atsushi Goto, Masahiro Nakatochi, Yoichi Sutoh, Akira Narita, Shiori Nakano, Ryoko Katagiri, Kenji Wakai, Naoyuki Takashima, Teruhide Koyama, Kokichi Arisawa, Issei Imoto, Yukihide Momozawa, Kozo Tanno, Atsushi Shimizu, Atsushi Hozawa, Keng American Journal of Ophthalmology.2023; 245: 193. CrossRef - Microbiome Dysbiosis: A Pathological Mechanism at the Intersection of Obesity and Glaucoma
Salvatore Pezzino, Maria Sofia, Luigi Piero Greco, Giorgia Litrico, Giulia Filippello, Iacopo Sarvà, Gaetano La Greca, Saverio Latteri International Journal of Molecular Sciences.2023; 24(2): 1166. CrossRef - Phenotypic and Genetic Links between Body Fat Measurements and Primary Open-Angle Glaucoma
Shi Song Rong, Xinting Yu International Journal of Molecular Sciences.2023; 24(4): 3925. CrossRef - Metabolic Health, Obesity, and Intraocular Pressure
Younhea Jung, Gyoung Nyun Kim, Eun Byeol Oh, Kyoung Ohn, Jung Il Moon Journal of Clinical Medicine.2023; 12(5): 2066. CrossRef - Association between lifestyle habits and glaucoma incidence: a retrospective cohort study
Asahi Fujita, Yohei Hashimoto, Hiroki Matsui, Hideo Yasunaga, Makoto Aihara Eye.2023; 37(16): 3470. CrossRef - Towards precision medicine in bariatric surgery prescription
Sofia S. Pereira, Marta Guimarães, Mariana P. Monteiro Reviews in Endocrine and Metabolic Disorders.2023; 24(5): 961. CrossRef - Study of the relationship between serum lipid levels and primary open-angle glaucoma
Rajesh Subhash Joshi, Vaishnavi Hitesh Adatiya Indian Journal of Ophthalmology.2023; 71(5): 1948. CrossRef - Primary open-angle glaucoma risk prediction with ABCA1 and LOC102723944 variants and their genotype–phenotype correlations in southern Chinese population
Zhenggen Wu, Chukai Huang, Yuqian Zheng, Xiang-Ling Yuan, Shaowan Chen, Yanxuan Xu, Li Jia Chen, Chi Pui Pang, Mingzhi Zhang, Tsz Kin Ng Molecular Genetics and Genomics.2023; 298(6): 1343. CrossRef - Differences in Factors Associated With Glaucoma Progression With Lower Normal Intraocular Pressure in Superior and Inferior Halves of the Optic Nerve Head
Ryo Asaoka, Rei Sakata, Takeshi Yoshitomi, Aiko Iwase, Chota Matsumoto, Tomomi Higashide, Motohiro Shirakashi, Makoto Aihara, Kazuhisa Sugiyama, Makoto Araie Translational Vision Science & Technology.2023; 12(8): 19. CrossRef - The association between obesity and glaucoma in older adults: evidence from the China Health and Retirement Longitudinal Study
Xiaohuan Zhao, Qiyu Bo, Junran Sun, Jieqiong Chen, Tong Li, Xiaoxu Huang, Minwen Zhou, Jing Wang, Wenjia Liu, Xiaodong Sun Epidemiology and Health.2023; 45: e2023034. CrossRef - Metabolic syndrome as an independent risk factor for glaucoma: a nationally representative study
Jun-Hyuk Lee, Yu-Jin Kwon, Sung Jin Kim, Boyoung Joung Diabetology & Metabolic Syndrome.2023;[Epub] CrossRef - Angiotensin Converting Enzyme Inhibitors: Interaction Issues in Patients with Glaucoma and Arterial Hypertension. Review
S. I. Makogon, D. I. Ivanova, A. L. Onishchenko Ophthalmology in Russia.2023; 20(4): 641. CrossRef - The role of the microbiota in glaucoma
Ling Huang, Yiwen Hong, Xiangyu Fu, Haishan Tan, Yongjiang Chen, Yujiao Wang, Danian Chen Molecular Aspects of Medicine.2023; 94: 101221. CrossRef - Girl Power in Glaucoma: The Role of Estrogen in Primary Open Angle Glaucoma
Kyrylo Fotesko, Bo Schneider Vohra Thomsen, Miriam Kolko, Rupali Vohra Cellular and Molecular Neurobiology.2022; 42(1): 41. CrossRef - Cholesterol and glaucoma: a systematic review and meta‐analysis
Laura Posch‐Pertl, Monja Michelitsch, Gernot Wagner, Brigitte Wildner, Günther Silbernagel, Gudrun Pregartner, Andreas Wedrich Acta Ophthalmologica.2022; 100(2): 148. CrossRef - Non-drug interventions in glaucoma: Putative roles for lifestyle, diet and nutritional supplements
Foroogh Fahmideh, Nicoletta Marchesi, Annalisa Barbieri, Stefano Govoni, Alessia Pascale Survey of Ophthalmology.2022; 67(3): 675. CrossRef - Relationship between Using Fibrate and Open-Angle Glaucoma in Hyperlipidemic Patients: A Population-Based Cohort Study
Yung-En Tsai, Yi-Hao Chen, Chien-An Sun, Chi-Hsiang Chung, Wu-Chien Chien, Ke-Hung Chien International Journal of Environmental Research and Public Health.2022; 19(4): 2415. CrossRef - The Causal Association Between Obesity and Primary Open-Angle Glaucoma: A Two-Sample Mendelian Randomization Study
Yi Lin, Xiaomin Zhu, Wangdu Luo, Bingcai Jiang, Qianyi Lin, Min Tang, Xiangji Li, Lin Xie Frontiers in Genetics.2022;[Epub] CrossRef - Enzymatic activity of paraoxonase depending on polymorphism Q192R of the PON1 gene in patients with primary open-angle glaucoma
Yu.E. Filippova, T.N. Malishevskaya, S.A. Petrov, D.G. Gubin, A.S. Vlasova Vestnik oftal'mologii.2022; 138(2): 58. CrossRef - Association of Metabolic Syndrome With Glaucoma and Ocular Hypertension in a Midwest United States Population
Kristi Y. Wu, David O. Hodge, Launia J. White, Jacinta McDonald, Gavin W. Roddy Journal of Glaucoma.2022; 31(6): e18. CrossRef - Metabolically Defined Body Size Phenotypes and Risk of Endometrial Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)
Nathalie Kliemann, Romain Ould Ammar, Carine Biessy, Audrey Gicquiau, Verena Katzke, Rudolf Kaaks, Anne Tjønneland, Anja Olsen, Maria-Jose Sánchez, Marta Crous-Bou, Fabrizio Pasanisi, Sandar Tin Tin, Aurora Perez-Cornago, Dagfinn Aune, Sofia Christakoudi, Cancer Epidemiology, Biomarkers & Prevention.2022; 31(7): 1359. CrossRef - Clinical Practice Management of Primary Open-Angle Glaucoma in the United States: An Analysis of Real-World Evidence
Joseph S Imperato, Kelly H Zou, Jim Z Li, Tarek A Hassan Patient Preference and Adherence.2022; Volume 16: 2213. CrossRef - Meta-Analysis of Dyslipidemia and Blood Lipid Parameters on the Risk of Primary Open-Angle Glaucoma
Guimei Huang, Jiayi Wang, Lei Li, Yuan Gao, Yijie Yan, Xi Lou Computational and Mathematical Methods in Medicine.2022; 2022: 1. CrossRef - Body shape and risk of glaucoma: A Mendelian randomization
Ruolan Yuan, Kangcheng Liu, Yingjun Cai, Fei He, Xiaoxiong Xiao, Jing Zou Frontiers in Medicine.2022;[Epub] CrossRef - Impact of Systemic Comorbidities on Ocular Hypertension and Open-Angle Glaucoma, in a Population from Spain and Portugal
Carolina Garcia-Villanueva, Elena Milla, José M. Bolarin, José J. García-Medina, Javier Cruz-Espinosa, Javier Benítez-del-Castillo, José Salgado-Borges, Francisco J. Hernández-Martínez, Elena Bendala-Tufanisco, Irene Andrés-Blasco, Alex Gallego-Martinez, Journal of Clinical Medicine.2022; 11(19): 5649. CrossRef - Metabolic syndrome and its components are associated with non-arteritic anterior ischaemic optic neuropathy
Darrell Kohli, Kristi Y Wu, Launia J White, David O Hodge, John J Chen, Gavin W Roddy BMJ Open Ophthalmology.2022; 7(1): e001111. CrossRef - Blood Pressure Measures and Incident Primary Open-Angle Glaucoma
Carmelo Macri, Christopher X. Wong, Samuel J. Tu, Robert Casson, Kuldev Singh, Sophia Y. Wang, Michelle T. Sun Investigative Opthalmology & Visual Science.2022; 63(13): 3. CrossRef - Relationship between anthropometric and biochemical changes of metabolic syndrome with retinal nerve fiber layer and macular thickness
Sze Hui New, Sue Ngein Leow, Suresh Kumar Vasudevan, Idayu Badilla Idris, Seng Fai Tang, Norshamsiah Md Din, Bang V Bui PLOS ONE.2021; 16(2): e0246830. CrossRef - Metabolic syndrome and the aging retina
Gavin W. Roddy Current Opinion in Ophthalmology.2021; 32(3): 280. CrossRef - Automated Detection of Glaucoma With Interpretable Machine Learning Using Clinical Data and Multimodal Retinal Images
Parmita Mehta, Christine A. Petersen, Joanne C. Wen, Michael R. Banitt, Philip P. Chen, Karine D. Bojikian, Catherine Egan, Su-In Lee, Magdalena Balazinska, Aaron Y. Lee, Ariel Rokem American Journal of Ophthalmology.2021; 231: 154. CrossRef - Association of Hypertriglyceridemia and Incident Glaucoma in a Rural Chinese Population: The Handan Eye Study
Ye Zhang, Qing Zhang, Ravi Thomas, Si Zhen Li, Ning Li Wang Translational Vision Science & Technology.2021; 10(8): 25. CrossRef - Risk of Glaucoma Associated with Components of Metabolic Disease in Taiwan: A Nationwide Population-Based Study
Ya-Wen Chang, Fung-Chang Sung, Ya-Ling Tzeng, Chih-Hsin Mou, Peng-Tai Tien, Cheng-Wen Su, Yu-Kuei Teng International Journal of Environmental Research and Public Health.2021; 19(1): 305. CrossRef - Metabolic Syndrome Is Associated With Ocular Hypertension and Glaucoma
Gavin W. Roddy Journal of Glaucoma.2020; 29(9): 726. CrossRef - Association of dipping status of blood pressure, visual field defects, and retinal nerve fiber layer thickness in patients with normotensive glaucoma
Seung Uk Lee, Han Su Park, Bong Joon Kim, Hyun Su Kim, Jung Ho Heo, Sung Il Im Medicine.2020; 99(50): e23565. CrossRef - Ocular findings in metabolic syndrome: a review
Mário Lima-Fontes, Pedro Barata, Manuel Falcão, Ângela Carneiro Porto Biomedical Journal.2020; 5(6): 104. CrossRef
|