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Eun Mi Park  (Park EM) 1 Article
Balsamic Vinegar Improves High Fat-Induced Beta Cell Dysfunction via Beta Cell ABCA1
Hannah Seok, Ji Young Lee, Eun Mi Park, Se Eun Park, Jae Hyuk Lee, Seungtaek Lim, Byung-Wan Lee, Eun Seok Kang, Hyun Chul Lee, Bong Soo Cha
Diabetes Metab J. 2012;36(4):275-279.   Published online August 20, 2012
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AbstractAbstract PDFPubReader   

The aim of this study was to investigate the effects of balsamic vinegar on β-cell dysfunction.


In this study, 28-week-old Otsuka Long-Evans Tokushima Fatty (OLETF) rats were fed a normal chow diet or a high-fat diet (HFD) and were provided with tap water or dilute balsamic vinegar for 4 weeks. Oral glucose tolerance tests and histopathological analyses were performed thereafter.


In rats fed both the both chow diet and the HFD, the rats given balsamic vinegar showed increased insulin staining in islets compared with tap water administered rats. Balsamic vinegar administration also increased β-cell ATP-binding cassette transporter subfamily A member 1 (ABCA1) expression in islets and decreased cholesterol levels.


These findings provide the first evidence for an anti-diabetic effect of balsamic vinegar through improvement of β-cell function via increasing β-cell ABCA1 expression.


Citations to this article as recorded by  
  • The herbal extract ALS-L1023 from Melissa officinalis reduces weight gain, elevated glucose levels and β-cell loss in Otsuka Long-Evans Tokushima fatty rats
    Yujin Shin, Dongju Lee, Jiwon Ahn, Mijeong Lee, Soon Shik Shin, Michung Yoon
    Journal of Ethnopharmacology.2021; 264: 113360.     CrossRef
  • The Effect of Balsamic Vinegar Dressing on Protein and Carbohydrate Digestibility is Dependent on the Food Matrix
    Eleonora Urbinati, Mattia Di Nunzio, Gianfranco Picone, Elena Chiarello, Alessandra Bordoni, Francesco Capozzi
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  • Safety and side effects of apple vinegar intake and its effect on metabolic parameters and body weight: a systematic review
    Tine Louise Launholt, Christina Blanner Kristiansen, Peter Hjorth
    European Journal of Nutrition.2020; 59(6): 2273.     CrossRef
  • Nypa fruticans Wurmb. Vinegar’s Aqueous Extract Stimulates Insulin Secretion and Exerts Hepatoprotective Effect on STZ-Induced Diabetic Rats
    Nor Yusoff, Vuanghao Lim, Bassel Al-Hindi, Khairul Abdul Razak, Tri Widyawati, Dwi Anggraini, Mariam Ahmad, Mohd Asmawi
    Nutrients.2017; 9(9): 925.     CrossRef
  • Cholesterol in Pancreatic β-Cell Death and Dysfunction
    Rajib Paul, Amarendranath Choudhury, Sabanum Choudhury, Muhammed K. Mazumder, Anupom Borah
    Pancreas.2016; 45(3): 317.     CrossRef
  • Chemical Characteristics and Immuno-Stimulatory Activity of Polysaccharides from Fermented Vinegars Manufactured with Different Raw Materials
    Dong-Su Kim, Byung Serk Hurh, Kwang-Soon Shin
    Journal of the Korean Society of Food Science and Nutrition.2015; 44(2): 191.     CrossRef
  • Effect and mechanisms of action of vinegar on glucose metabolism, lipid profile, and body weight
    Eleni I Petsiou, Panayota I Mitrou, Sotirios A Raptis, George D Dimitriadis
    Nutrition Reviews.2014; 72(10): 651.     CrossRef
  • Chemical Property and Macrophage Stimulating Activity of Polysaccharides isolated from Brown Rice and Persimmon Vinegars
    Dong-Su Kim, Kwang-Soon Shin
    The Korean Journal of Food And Nutrition.2014; 27(6): 1033.     CrossRef
  • Vinegar ingestion at mealtime reduced fasting blood glucose concentrations in healthy adults at risk for type 2 diabetes
    Carol S. Johnston, Samantha Quagliano, Serena White
    Journal of Functional Foods.2013; 5(4): 2007.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal