- Metabolic Risk/Epidemiology
- Intra-Abdominal Fat and High Density Lipoprotein Cholesterol Are Associated in a Non-Linear Pattern in Japanese-Americans
-
Sun Ok Song, You-Cheol Hwang, Steven E. Kahn, Donna L. Leonetti, Wilfred Y. Fujimoto, Edward J. Boyko
-
Diabetes Metab J. 2020;44(2):277-285. Published online March 10, 2020
-
DOI: https://doi.org/10.4093/dmj.2019.0008
-
-
5,697
View
-
74
Download
-
4
Web of Science
-
5
Crossref
-
 Abstract
 PDF PubReader
- Background
We describe the association between high density lipoprotein cholesterol (HDL-C) concentration and computed tomography (CT)-measured fat depots. MethodsWe examined the cross-sectional associations between HDL-C concentration and intra-abdominal (IAF), abdominal subcutaneous (SCF), and thigh fat (TF) areas in 641 Japanese-American men and women. IAF, SCF, and TF were measured by CT at the level of the umbilicus and mid-thigh. The associations between fat area measurements and HDL-C were examined using multivariate linear regression analysis adjusting for age, sex, diabetes family history, homeostasis model assessment of insulin resistance (HOMA-IR), and body mass index (BMI). Non-linearity was assessed using fractional polynomials. ResultsMean±standard deviation of HDL-C concentration and IAF in men and women were 1.30±0.34 mg/dL, 105±55.3 cm2, and 1.67±0.43 mg/dL, 74.4±46.6 cm2 and differed significantly by gender for both comparisons (P<0.001). In univariate analysis, HDL-C concentration was significantly associated with CT-measured fat depots. In multivariate analysis, IAF was significantly and non-linearly associated with HDL-C concentration adjusted for age, sex, BMI, HOMA-IR, SCF, and TF (IAF: β=−0.1012, P<0.001; IAF2: β=0.0008, P<0.001). SCF was also negatively and linearly associated with HDL-C (β=−0.4919, P=0.001). ConclusionHDL-C does not linearly decline with increasing IAF in Japanese-Americans. A more complex pattern better fits this association.
-
Citations
Citations to this article as recorded by  - Associations of Serum Uric Acid to High-Density Lipoprotein Cholesterol Ratio with Trunk Fat Mass and Visceral Fat Accumulation
Yansu Wang, Yiting Xu, Tingting Hu, Yunfeng Xiao, Yufei Wang, Xiaojing Ma, Haoyong Yu, Yuqian Bao
Diabetes, Metabolic Syndrome and Obesity.2024; Volume 17: 121. CrossRef - Impact of the COVID-19 Pandemic on Obesity, Metabolic Parameters and Clinical Values in the South Korean Adult Population
Anna Kim, Eun-yeob Kim, Jaeyoung Kim
Journal of Clinical Medicine.2024; 13(10): 2814. CrossRef - Obesity-related parameters in carriers of some BDNF genetic variants may depend on daily dietary macronutrients intake
Urszula Miksza, Edyta Adamska-Patruno, Witold Bauer, Joanna Fiedorczuk, Przemyslaw Czajkowski, Monika Moroz, Krzysztof Drygalski, Andrzej Ustymowicz, Elwira Tomkiewicz, Maria Gorska, Adam Kretowski
Scientific Reports.2023;[Epub] CrossRef - Computed tomography-based investigation of the correlation of abdominal fat areas with metabolic syndrome
Kai-Yuan Cheng, Tsung-Hsien Yen, Jay Wu, Pei-Hsuan Li, Tian-Yu Shih
Journal of Radiological Science.2023; 48(1): 15. CrossRef - Lower High-Density Lipoprotein Cholesterol Concentration Is Independently Associated with Greater Future Accumulation of Intra-Abdominal Fat
Sun Ok Song, You-Cheol Hwang, Han Uk Ryu, Steven E. Kahn, Donna L. Leonetti, Wilfred Y. Fujimoto, Edward J. Boyko
Endocrinology and Metabolism.2021; 36(4): 835. CrossRef
- Obesity and Metabolic Syndrome
- Metabolic Consequences of Obstructive Sleep Apnea Especially Pertaining to Diabetes Mellitus and Insulin Sensitivity
-
Sun Ok Song, Ken He, Radhika R. Narla, Hyun Goo Kang, Han Uk Ryu, Edward J. Boyko
-
Diabetes Metab J. 2019;43(2):144-155. Published online April 15, 2019
-
DOI: https://doi.org/10.4093/dmj.2018.0256
-
-
9,834
View
-
191
Download
-
56
Web of Science
-
58
Crossref
-
Abstract
PDFPubReader
Obstructive sleep apnea (OSA) and diabetes has been known to be closely related to each other and both diseases impact highly on the public health. There are many evidence of reports that OSA is associated with diabetes with a bidirectional correlation. A possible causal mechanism of OSA to diabetes is intermittent hypoxemia and diabetes to OSA is microvascular complication. However, OSA and diabetes have a high prevalence rate in public and shares the common overlap characteristic and risk factors such as age, obesity, and metabolic syndrome that make it difficult to establish the exact pathophysiologic mechanism between them. In addition, studies demonstrating that treatment of OSA may help prevent diabetes or improve glycemic control have not shown convincing result but have become a great field of interest research. This review outlines the bidirectional correlation between OSA and diabetes and explore the pathophysiologic mechanisms by approaching their basic etiologies. -
Citations
Citations to this article as recorded by
- Obesity and Metabolic Syndrome
- Higher High Density Lipoprotein 2 (HDL2) to Total HDL Cholesterol Ratio Is Associated with a Lower Risk for Incident Hypertension
-
You-Cheol Hwang, Wilfred Y. Fujimoto, Steven E. Kahn, Donna L. Leonetti, Edward J. Boyko
-
Diabetes Metab J. 2019;43(1):114-122. Published online September 28, 2018
-
DOI: https://doi.org/10.4093/dmj.2018.0053
-
-
5,281
View
-
51
Download
-
9
Web of Science
-
12
Crossref
-
Abstract
PDFPubReader
- Background
Recent studies have suggested that high density lipoprotein (HDL) cholesterol is inversely associated with the development of hypertension. We aimed to determine the association between different HDL cholesterol subclasses and risk of future hypertension. MethodsA total of 270 Japanese Americans (130 men, 140 women) without hypertension between the ages of 34 to 75 years were enrolled. Blood pressure was measured with a mercury sphygmomanometer, and average blood pressure was calculated. Incident hypertension was determined 5 to 6 and 10 to 11 years after enrollment. HDL2, HDL3, and total HDL cholesterol were measured at baseline. ResultsDuring 10 years of follow-up, the cumulative incidence of hypertension was 28.1% (76/270). In univariate analysis, age, diabetes, waist circumference, systolic and diastolic blood pressure, fasting glucose, insulin resistance index, total and low density lipoprotein cholesterol, and visceral adipose tissue were significant predictors for incident hypertension. Among the HDL cholesterol subclass, HDL2 cholesterol was inversely associated with hypertension incidence, but both total and HDL3 cholesterol were not. In addition, HDL2/HDL cholesterol was inversely associated with future hypertension risk. In multivariate analysis, age (odds ratio [OR], 1.71; 95% confidence interval [CI], 1.26 to 2.31; P=0.001), systolic blood pressure (OR, 1.83; 95% CI, 1.31 to 2.56; P<0.001), and HDL2/HDL cholesterol (OR, 0.71; 95% CI, 0.52 to 0.98; P=0.035), were associated with future development of hypertension. ConclusionA higher proportion of HDL2 cholesterol among total HDL cholesterol predicted a lower risk for incident hypertension. However, concentrations of total HDL, HDL2, and HDL3 cholesterol were not independent predictors of incident hypertension.
-
Citations
Citations to this article as recorded by - The Association of HDL2b with Metabolic Syndrome Among Normal HDL-C Populations in Southern China
Tong Chen, Shiquan Wu, Ling Feng, SiYu Long, Yu Liu, WenQian Lu, Wenya Chen, Guoai Hong, Li Zhou, Fang Wang, Yuechan Luo, Hequn Zou
Diabetes, Metabolic Syndrome and Obesity.2024; Volume 17: 363. CrossRef - Long-term PM1 exposure and hypertension hospitalization: A causal inference study on a large community-based cohort in South China
Yuqin Zhang, Shirui Chen, Jing Wei, Jie Jiang, Xiao Lin, Ying Wang, Chun Hao, Wenjing Wu, Zhupei Yuan, Jie Sun, Han Wang, Zhicheng Du, Wangjian Zhang, Yuantao Hao
Science Bulletin.2024; 69(9): 1313. CrossRef - High-Density Lipoprotein Signaling via Sphingosine-1-Phosphate Receptors Safeguards Spontaneously Hypertensive Rats against Myocardial Ischemia/Reperfusion Injury
Aishah Al-Jarallah, Fawzi A. Babiker
Pharmaceutics.2024; 16(4): 497. CrossRef - The association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and prevalence of urinary stones in US adults: a cross-sectional NHANES study
Heng Liu, Yu Zhou, Mingchu Jin, Haidong Hao, Yutang Yuan, Hongtao Jia
International Urology and Nephrology.2024; 56(12): 3895. CrossRef - Relationship Between the High Blood Pressure and Cholesterol in the Women
Noor Nemia Hafed
European Journal of Theoretical and Applied Sciences.2024; 2(4): 538. CrossRef - Effects of cardiometabolic risk factors on blood pressure in outpatients at Sominé DOLO hospital, Mopti, Mali
Modibo Coulibaly, Adama Kondé, Djibril Traoré, Ousmane Bah, Valentin Sagara, Bakary Maiga
International Journal of Clinical Biochemistry and Research.2023; 10(1): 87. CrossRef - The association of lipid metabolism with bone metabolism and the role of human traits: a Mendelian randomization study
Jian Kang, Shuangli Zhao, Xize Wu, Can Wang, Zongkun Jiang, Shixuan Wang
Frontiers in Endocrinology.2023;[Epub] CrossRef - The role of different lipid measures for incident hypertension during more than 12-year follow-up: Tehran Lipid and Glucose Study
Amirreza Hadaegh, Samaneh Akbarpour, Maryam Tohidi, Niloofar Barzegar, Somayeh Hosseinpour-Niazi, Fereidoun Azizi, Farzad Hadaegh
British Journal of Nutrition.2022; 128(9): 1700. CrossRef - High Density Lipoprotein Reduces Blood Pressure and Protects Spontaneously Hypertensive Rats Against Myocardial Ischemia-Reperfusion Injury in an SR-BI Dependent Manner
Aishah Al-Jarallah, Fawzi Babiker
Frontiers in Cardiovascular Medicine.2022;[Epub] CrossRef - Association between the Uric Acid to High Density Lipoprotein Cholesterol Ratio and Systolic Pressure in Chinese Short Stature Children and Adolescents
广欣 李
Advances in Clinical Medicine.2022; 12(09): 8266. CrossRef - Associations Between Peripheral Blood Microbiome and the Risk of Hypertension
Yang Jing, Hui Zhou, Honghong Lu, Xiaofang Chen, Liangyue Zhou, Jingqi Zhang, Jing Wu, Chen Dong
American Journal of Hypertension.2021; 34(10): 1064. CrossRef - How was the Diabetes Metabolism Journal added to MEDLINE?
Hye Jin Yoo
Science Editing.2020; 7(2): 201. CrossRef
- Epidemiology
- Association of Thigh Muscle Mass with Insulin Resistance and Incident Type 2 Diabetes Mellitus in Japanese Americans
-
Seung Jin Han, Edward J. Boyko, Soo-Kyung Kim, Wilfred Y. Fujimoto, Steven E. Kahn, Donna L. Leonetti
-
Diabetes Metab J. 2018;42(6):488-495. Published online September 5, 2018
-
DOI: https://doi.org/10.4093/dmj.2018.0022
-
-
5,526
View
-
79
Download
-
37
Web of Science
-
37
Crossref
-
Abstract
PDFPubReader
- Background
Skeletal muscle plays a major role in glucose metabolism. We investigated the association between thigh muscle mass, insulin resistance, and incident type 2 diabetes mellitus (T2DM) risk. In addition, we examined the role of body mass index (BMI) as a potential effect modifier in this association. MethodsThis prospective study included 399 Japanese Americans without diabetes (mean age 51.6 years) who at baseline had an estimation of thigh muscle mass by computed tomography and at baseline and after 10 years of follow-up a 75-g oral glucose tolerance test and determination of homeostasis model assessment of insulin resistance (HOMA-IR). We fit regression models to examine the association between thigh muscle area and incidence of T2DM and change in HOMA-IR, both measured over 10 years. ResultsThigh muscle area was inversely associated with future HOMA-IR after adjustment for age, sex, BMI, HOMA-IR, fasting plasma glucose, total abdominal fat area, and thigh subcutaneous fat area at baseline (P=0.033). The 10-year cumulative incidence of T2DM was 22.1%. A statistically significant interaction between thigh muscle area and BMI was observed, i.e., greater thigh muscle area was associated with lower risk of incident T2DM for subjects at lower levels of BMI, but this association diminished at higher BMI levels. ConclusionThigh muscle mass area was inversely associated with future insulin resistance. Greater thigh muscle area predicts a lower risk of incident T2DM for leaner Japanese Americans.
-
Citations
Citations to this article as recorded by - Unraveling the role of muscle mass and strength in predicting type 2 diabetes risk: a systematic review
Hans Putranata, Antoninus Hengky, Budhi Hartoko
Acta Diabetologica.2025;[Epub] CrossRef - Shape phenotype of thigh fat and muscle and risk of major adverse cardiovascular events after fragility hip fracture
Sheen‐Woo Lee, Seung‐Chan Kim, Jeong‐Eun Yi
Journal of Cachexia, Sarcopenia and Muscle.2024; 15(1): 331. CrossRef - CD36 gene variant rs1761667(G/A) as a biomarker in obese type 2 diabetes mellitus cases
Ashwin Kumar Shukla, Amreen Shamsad, Atar Singh Kushwah, Shalini Singh, Kauser Usman, Monisha Banerjee
Egyptian Journal of Medical Human Genetics.2024;[Epub] CrossRef - Association between macro- and microvascular damage and sarcopenia index in individuals with type 2 diabetes mellitus
Hui Xu, Qun-Yan Xiang, Jun-Kun Zhan, Yi Wang, Yan-Jiao Wang, Shuang Li, You-Shuo Liu
Applied Physiology, Nutrition, and Metabolism.2024; 49(6): 762. CrossRef - MicroRNA‐29‐mediated cross‐talk between metabolic organs in the pathogenesis of diabetes mellitus and its complications: A narrative review
Hassen Ahmed Yesuf, Meseret Derbew Molla, Tabarak Malik, Zeru Seyoum Wendimagegn, Yadelew Yimer
Cell Biochemistry and Function.2024;[Epub] CrossRef - Causality between sarcopenia and diabetic neuropathy
Yi Fang, Xiaoqing Yuan, Qing Zhang, Juan Liu, Qing Yao, Xinhua Ye
Frontiers in Endocrinology.2024;[Epub] CrossRef - More appendicular lean mass relative to body mass index is associated with lower incident diabetes in middle-aged adults in the CARDIA study
Melanie S. Haines, Aaron Leong, Bianca C. Porneala, Victor W. Zhong, Cora E. Lewis, Pamela J. Schreiner, Karen K. Miller, James B. Meigs, Mercedes R. Carnethon
Nutrition, Metabolism and Cardiovascular Diseases.2023; 33(1): 105. CrossRef - Involvement of the fecal amino acid profile in a clinical and anthropometric study of Mexican patients with insulin resistance and type 2 diabetes mellitus
Mayra Paloma Macías-Acosta, Lorena Valerdi-Contreras, Ericka Denise Bustos-Angel, Rudy Antonio García-Reyes, Monserrat Alvarez-Zavala, Marisela González-Ávila
Amino Acids.2022; 54(1): 47. CrossRef - Association of serum creatinine levels and risk of type 2 diabetes mellitus in Korea: a case control study
Do Kyeong Song, Young Sun Hong, Yeon-Ah Sung, Hyejin Lee
BMC Endocrine Disorders.2022;[Epub] CrossRef - The Relationship Between Fat-Free Mass and Glucose Metabolism in Children and Adolescents: A Systematic Review and Meta-Analysis
Lijun Wu, Fangfang Chen, Junting Liu, Dongqing Hou, Tao Li, Yiren Chen, Zijun Liao
Frontiers in Pediatrics.2022;[Epub] CrossRef - Is imaging-based muscle quantity associated with risk of diabetes? A meta-analysis of cohort studies
Shanhu Qiu, Xue Cai, Yang Yuan, Bo Xie, Zilin Sun, Tongzhi Wu
Diabetes Research and Clinical Practice.2022; 189: 109939. CrossRef - Effects of Exercise Intervention on Type 2 Diabetes Patients With Abdominal Obesity and Low Thigh Circumference (EXTEND): Study Protocol for a Randomized Controlled Trial
Dan Liu, Ying Zhang, Liang Wu, Jingyi Guo, Xiangtian Yu, Huasheng Yao, Rui Han, Tianshu Ma, Yuchan Zheng, Qiongmei Gao, Qichen Fang, Yan Zhao, Yanan Zhao, Biao Sun, Weiping Jia, Huating Li
Frontiers in Endocrinology.2022;[Epub] CrossRef - Association between diabetic peripheral neuropathy and sarcopenia: A systematic review and meta‐analysis
Thapat Wannarong, Persen Sukpornchairak, Weerakit Naweera, Christopher D. Geiger, Patompong Ungprasert
Geriatrics & Gerontology International.2022; 22(9): 785. CrossRef - Synergistic Interaction between Hyperuricemia and Abdominal Obesity as a Risk Factor for Metabolic Syndrome Components in Korean Population
Min Jin Lee, Ah Reum Khang, Yang Ho Kang, Mi Sook Yun, Dongwon Yi
Diabetes & Metabolism Journal.2022; 46(5): 756. CrossRef - HOMA-IR as a predictor of Health Outcomes in Patients with Metabolic Risk Factors: A Systematic Review and Meta-analysis
José G. González-González, Jorge R. Violante-Cumpa, Miguel Zambrano-Lucio, Erick Burciaga-Jimenez, Patricia L. Castillo-Morales, Mariano Garcia-Campa, Ricardo César Solis, Alejandro D González-Colmenero, René Rodríguez-Gutiérrez
High Blood Pressure & Cardiovascular Prevention.2022; 29(6): 547. CrossRef - Maternal height as a predictor of glucose intolerance in the postpartum and its relationship with maternal pre-gestational weight
Catarina Cidade-Rodrigues, Filipe M. Cunha, Catarina Chaves, Fabiana Castro, Catarina Pereira, Sílvia Paredes, Margarida Silva-Vieira, Anabela Melo, Odete Figueiredo, Cláudia Nogueira, Ana Morgado, Mariana Martinho, Maria C. Almeida, Margarida Almeida
Archives of Gynecology and Obstetrics.2022; 307(2): 601. CrossRef - Correlation of body composition in early pregnancy on gestational diabetes mellitus under different body weights before pregnancy
Li Xintong, Xu Dongmei, Zhang Li, Cao Ruimin, Hao Yide, Cui Lingling, Chen Tingting, Guo Yingying, Li Jiaxin
Frontiers in Endocrinology.2022;[Epub] CrossRef - Relationship between low skeletal muscle mass, sarcopenic obesity and left ventricular diastolic dysfunction in Korean adults
Jee Hee Yoo, Sung Woon Park, Ji Eun Jun, Sang‐Man Jin, Kyu Yeon Hur, Moon‐Kyu Lee, Mira Kang, Gyuri Kim, Jae Hyeon Kim
Diabetes/Metabolism Research and Reviews.2021;[Epub] CrossRef - Skeletal Muscle and Metabolic Health: How Do We Increase Muscle Mass and Function in People with Type 2 Diabetes?
Ebaa Al-Ozairi, Dalal Alsaeed, Dherar Alroudhan, Nia Voase, Amal Hasan, Jason M R Gill, Naveed Sattar, Paul Welsh, Cindy M Gray, Jirapitcha Boonpor, Carlos Celis-Morales, Stuart R Gray
The Journal of Clinical Endocrinology & Metabolism.2021; 106(2): 309. CrossRef - Association of the triglyceride and glucose index with low muscle mass: KNHANES 2008–2011
Jung A. Kim, Soon Young Hwang, Ji Hee Yu, Eun Roh, So-hyeon Hong, You-Bin Lee, Nam Hoon Kim, Hye Jin Yoo, Ji A. Seo, Nan Hee Kim, Sin Gon Kim, Sei Hyun Baik, Kyung Mook Choi
Scientific Reports.2021;[Epub] CrossRef - ADAS-viewer: web-based application for integrative analysis of multi-omics data in Alzheimer’s disease
Seonggyun Han, Jaehang Shin, Hyeim Jung, Jane Ryu, Habtamu Minassie, Kwangsik Nho, Insong Koh, Younghee Lee
npj Systems Biology and Applications.2021;[Epub] CrossRef - Relative associations of abdominal and thigh compositions with cardiometabolic diseases in African Caribbean men
Curtis Tilves, Joseph M. Zmuda, Allison L. Kuipers, Sangeeta Nair, John Jeffrey Carr, James G. Terry, Shyamal Peddada, Victor Wheeler, Iva Miljkovic
Obesity Science & Practice.2021; 7(6): 738. CrossRef - Changes in creatinine‐to‐cystatin C ratio over 4 years, risk of diabetes, and cardiometabolic control: The China Health and Retirement Longitudinal Study
Shanhu Qiu, Xue Cai, Yang Yuan, Bo Xie, Zilin Sun, Tongzhi Wu
Journal of Diabetes.2021; 13(12): 1025. CrossRef - Associations Between Glucose Tolerance, Insulin Secretion, Muscle and Fat Mass in Cystic Fibrosis
Bibi Uhre Nielsen, Daniel Faurholt-Jepsen, Peter Sandor Oturai, Tavs Qvist, Rikke Krogh-Madsen, Terese Lea Katzenstein, James Shaw, Christian Ritz, Tacjana Pressler, Thomas Peter Almdal, Inger Hee Mabuza Mathiesen
Clinical Medicine Insights: Endocrinology and Diabetes.2021;[Epub] CrossRef - Total and regional fat‐to‐muscle mass ratio measured by bioelectrical impedance and risk of incident type 2 diabetes
Ningjian Wang, Ying Sun, Haojie Zhang, Chi Chen, Yuying Wang, Jihui Zhang, Fangzhen Xia, Christian Benedict, Xiao Tan, Yingli Lu
Journal of Cachexia, Sarcopenia and Muscle.2021; 12(6): 2154. CrossRef - How was the Diabetes Metabolism Journal added to MEDLINE?
Hye Jin Yoo
Science Editing.2020; 7(2): 201. CrossRef - An update on nutrient modulation in the management of disease-induced muscle wasting: evidence from human studies
Matthew S. Brook, Daniel J. Wilkinson, Philip J. Atherton
Current Opinion in Clinical Nutrition & Metabolic Care.2020; 23(3): 174. CrossRef - The functional nutritional and regulatory activities of calcium supplementation from eggshell for obesity disorders management
Marwa El‐Zeftawy, Samar Abd‐El Mohsen Ali, Sally Salah, Hani S. Hafez
Journal of Food Biochemistry.2020;[Epub] CrossRef - Dose‐response associations between serum creatinine and type 2 diabetes mellitus risk: A Chinese cohort study and meta‐analysis of cohort studies
Pei Qin, Yanmei Lou, Liming Cao, Jing Shi, Gang Tian, Dechen Liu, Qionggui Zhou, Chunmei Guo, Quanman Li, Yang Zhao, Feiyan Liu, Xiaoyan Wu, Ranran Qie, Minghui Han, Shengbing Huang, Ping Zhao, Changyi Wang, Jianping Ma, Xiaolin Peng, Shan Xu, Hongen Chen
Journal of Diabetes.2020; 12(8): 594. CrossRef - Caloric restriction in heart failure: A systematic review
Vittorio Emanuele Bianchi
Clinical Nutrition ESPEN.2020; 38: 50. CrossRef - Association between the Thigh Muscle and Insulin Resistance According to Body Mass Index in Middle-Aged Korean Adults
Ji Eun Heo, Jee-Seon Shim, Hokyou Lee, Hyeon Chang Kim
Diabetes & Metabolism Journal.2020; 44(3): 446. CrossRef - Joint impact of muscle mass and waist circumference on type 2 diabetes in Japanese middle‐aged adults: The Circulatory Risk in Communities Study (CIRCS)
Mikako Yasuoka, Isao Muraki, Hironori Imano, Hiroshige Jinnouchi, Yasuhiko Kubota, Mina Hayama‐Terada, Mitsumasa Umesawa, Kazumasa Yamagishi, Tetsuya Ohira, Akihiko Kitamura, Takeo Okada, Masahiko Kiyama, Hiroyasu Iso
Journal of Diabetes.2020; 12(9): 677. CrossRef - Catch-Up Growth in Children Born Small for Gestational Age Related to Body Composition and Metabolic Risk at Six Years of Age in the UK
M. Loredana Marcovecchio, Samantha Gorman, Laura P.E. Watson, David B. Dunger, Kathryn Beardsall
Hormone Research in Paediatrics.2020; 93(2): 119. CrossRef - Response: Association of Thigh Muscle Mass with Insulin Resistance and Incident Type 2 Diabetes Mellitus in Japanese Americans (Diabetes Metab J 2018;42:488–95)
Seung Jin Han, Edward J. Boyko
Diabetes & Metabolism Journal.2019; 43(1): 125. CrossRef - Berberine chloride ameliorated PI3K/Akt‐p/SIRT‐1/PTEN signaling pathway in insulin resistance syndrome induced in rats
Marwa El‐Zeftawy, Doaa Ghareeb, Eman R. ElBealy, Rasha Saad, Salma Mahmoud, Nihal Elguindy, Attalla F. El‐kott, Mohamed El‐Sayed
Journal of Food Biochemistry.2019;[Epub] CrossRef - Letter: Association of Thigh Muscle Mass with Insulin Resistance and Incident Type 2 Diabetes Mellitus in Japanese Americans (Diabetes Metab J 2018;42:488–95)
Nan Hee Cho, Hye Soon Kim
Diabetes & Metabolism Journal.2019; 43(1): 123. CrossRef - Asian Indians With Prediabetes Have Similar Skeletal Muscle Mass and Function to Those With Type 2 Diabetes
Sucharita Sambashivaiah, Stephen D. R. Harridge, Nidhi Sharma, Sumithra Selvam, Priyanka Rohatgi, Anura V. Kurpad
Frontiers in Nutrition.2019;[Epub] CrossRef
- Epidemiology
- The Evidence for an Obesity Paradox in Type 2 Diabetes Mellitus
-
Seung Jin Han, Edward J. Boyko
-
Diabetes Metab J. 2018;42(3):179-187. Published online May 31, 2018
-
DOI: https://doi.org/10.4093/dmj.2018.0055
-
-
8,819
View
-
160
Download
-
66
Web of Science
-
69
Crossref
-
Abstract
PDFPubReader
Although overweight/obesity is a major risk factor for the development of type 2 diabetes mellitus, there is increasing evidence that overweight or obese patients with type 2 diabetes mellitus experience lower mortality compared with patients of normal weight. This paradoxical finding, known as the “obesity paradox,” occurs in other chronic diseases, and in type 2 diabetes mellitus is particularly perplexing given that lifestyle intervention with one goal being weight reduction is an important feature of the management of this condition. We summarize in this review the findings from clinical and epidemiologic studies that have investigated the association between overweight and obesity (usually assessed using body mass index [BMI]) and mortality in type 2 diabetes mellitus and discuss potential causes of the obesity paradox. We conclude that most studies show evidence of an obesity paradox, but important conflicting findings still exist. We also evaluate if potential bias might explain the obesity paradox in diabetes, including, for example, the presence of confounding factors, measurement error due to use of BMI as an index of obesity, and reverse causation. -
Citations
Citations to this article as recorded by - Influence of diabetes and obesity on ten-year outcomes after coronary artery bypass grafting in the arterial revascularisation trial
Maria Stefil, Mario Gaudino, Umberto Benedetto, Stephen Gerry, Alastair Gray, Belinda Lees, Bruno Podesser, Lukasz Krzych, Lokeswara Rao Sajja, David Taggart, Marcus Flather
Clinical Research in Cardiology.2024; 113(11): 1515. CrossRef - Association between the weight-adjusted waist index and the odds of type 2 diabetes mellitus in United States adults: a cross-sectional study
Dongdong Zheng, Suzhen Zhao, Dan Luo, Feng Lu, Zhishen Ruan, Xiaokang Dong, Wenjing Chen
Frontiers in Endocrinology.2024;[Epub] CrossRef - Racial and Ethnic Disparities in Primary Prevention of Cardiovascular Disease
Mohammad R. Ali, Hadjer Nacer, Claire A. Lawson, Kamlesh Khunti
Canadian Journal of Cardiology.2024; 40(6): 1016. CrossRef - Mortality outcomes in diabetic metabolic dysfunction-associated fatty liver disease: non-obese versus obese individuals
Pengwei Zhang, Yijun Zeng, Sijia Yang, Chunhong Ye, Mingwei Wang, Tianfang Peng, Li Li, Xianhui Dong
Scientific Reports.2024;[Epub] CrossRef - Independent and interactive associations of heart rate and obesity with type 2 diabetes mellites: A population‐based study
Tianxin Zhu, Qingyu Chen, Hongxing Chen, Lili You, Dan Liu, Xiaoyun Zhang, Feng Li, Hongshi Wu, Juying Tang, Diaozhu Lin, Kan Sun, Li Yan, Meng Ren
Journal of Diabetes.2024;[Epub] CrossRef - Investigating the causal association of generalized and abdominal obesity with microvascular complications in patients with type 2 diabetes: A community‐based prospective study
Jiaheng Chen, Yu Ting Li, Zimin Niu, Zhanpeng He, Yao Jie Xie, Jose Hernandez, Wenyong Huang, Harry H X Wang
Diabetes, Obesity and Metabolism.2024; 26(7): 2796. CrossRef - Causal relationships of lifestyle behaviours and body fat distribution on diabetic microvascular complications: a Mendelian randomization study
Nuojin Guo, Hekai Shi, Hongmei Zhao, Yierfan Abuduani, Da Chen, Xishuang Chen, Hua Wang, Peicheng Li
Frontiers in Genetics.2024;[Epub] CrossRef - Effect of body mass index on mortality for diabetic patients with aortic stenosis
Kai-Chun Chang, Li-Ting Ho, Kuan-Chih Huang, Jung-Chi Hsu, David Te-Wei Kuan, Ting-Tse Lin, Jen-Kuang Lee, Yen-Yun Yang, Shu-Lin Chuang, Lian-Yu Lin
Aging.2024; 16(14): 11359. CrossRef - Clinical impact of visceral adiposity on long-term mortality in patients undergoing coronary artery bypass grafting
Jinhwan Jo, Seung Hun Lee, Jeong Hoon Yang, Sung Mok Kim, Ki Hong Choi, Young Bin Song, Dong Seop Jeong, Joo Myung Lee, Taek Kyu Park, Joo-Yong Hahn, Seung-Hyuk Choi, Su Ryeun Chung, Yang Hyun Cho, Kiick Sung, Wook Sung Kim, Hyeon-Cheol Gwon, Young Tak Le
Revista Española de Cardiología (English Edition).2024;[Epub] CrossRef - Exploring lipodystrophy gene expression in adipocytes: unveiling insights into the pathogenesis of insulin resistance, type 2 diabetes, and clustering diseases (metabolic syndrome) in Asian Indians
Aditya Saxena, Pradeep Tiwari, Shalu Gupta, Rajendra Mandia, Ramesh C. Banshiwal, Ravinder Kumar Lamoria, Ranjit Mohan Anjana, Venkatesan Radha, Viswanathan Mohan, Sandeep Kumar Mathur
Frontiers in Endocrinology.2024;[Epub] CrossRef - The effect of weight reduction on the diabetes foot: A scoping review and clinical implications
Janine Elizabeth Roll Ahmed, John Veto, Derek Santos
Obesity Pillars.2024; : 100152. CrossRef - Impacto clínico de la adiposidad visceral en la mortalidad a largo plazo de pacientes sometidos a revascularización coronaria
Jinhwan Jo, Seung Hun Lee, Jeong Hoon Yang, Sung Mok Kim, Ki Hong Choi, Young Bin Song, Dong Seop Jeong, Joo Myung Lee, Taek Kyu Park, Joo-Yong Hahn, Seung-Hyuk Choi, Su Ryeun Chung, Yang Hyun Cho, Kiick Sung, Wook Sung Kim, Hyeon-Cheol Gwon, Young Tak Le
Revista Española de Cardiología.2024;[Epub] CrossRef - Two‐sided roles of adipose tissue: Rethinking the obesity paradox in various human diseases from a new perspective
Jing Pan, Jianqiong Yin, Lu Gan, Jianxin Xue
Obesity Reviews.2023;[Epub] CrossRef - Lean or diabetic subtypes predict increased all-cause and disease-specific mortality in metabolic-associated fatty liver disease
Goh Eun Chung, Su Jong Yu, Jeong-Ju Yoo, Yuri Cho, Kyu-na Lee, Dong Wook Shin, Donghee Kim, Yoon Jun Kim, Jung-Hwan Yoon, Kyungdo Han, Eun Ju Cho
BMC Medicine.2023;[Epub] CrossRef - Dynamic changes in prevalence of type 2 diabetes along with associated factors in Bangladesh: Evidence from two national cross-sectional surveys (BDHS 2011 and BDHS 2017–18)
Sabiha Shirin Sara, Ashis Talukder, Ka Yiu Lee, Nayan Basak, Shaharior Rahman Razu, Iqramul Haq, Chuton Deb Nath
Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2023; 17(2): 102706. CrossRef - Association of dietary intake with body mass index and glycemic profile among newly diagnosed patients with type 2 diabetes mellitus
Keddagoda Gamage Piyumi Wasana, Anoja Priyadarshani Attanayake, Thilak Priyantha Weerarathna, Devpura Arachchige Bandumalee Nimalshanthi Amarasekera, Kamani Ayoma Perera Wijewardana Jayatilaka
American Journal of Human Biology.2023;[Epub] CrossRef - Can lipophilic pollutants in adipose tissue explain weight change‐related risk in type 2 diabetes mellitus?
Duk‐Hee Lee, In‐Kyu Lee
Journal of Diabetes Investigation.2023; 14(4): 528. CrossRef - Visceral fat and attribute-based medicine in chronic kidney disease
Hiroshi Kataoka, Kosaku Nitta, Junichi Hoshino
Frontiers in Endocrinology.2023;[Epub] CrossRef - A primary care delivered, technology supported lifestyle program for Type 2 Diabetes Management: An evaluation of changes in metabolic health, feasibility, and acceptability – A pilot interventional study protocol
Pennie J. Taylor, Campbell H. Thompson, Thomas P. Wycherley, Grant D. Brinkworth
Contemporary Clinical Trials Communications.2023; 33: 101152. CrossRef - The medical model of “obesity” and the values behind the guise of health
Kayla R. Mehl
Synthese.2023;[Epub] CrossRef - Elevated MMP-8 levels, inversely associated with BMI, predict mortality in mechanically ventilated patients: an observational multicenter study
Hang Ruan, Shu-sheng Li, Qin Zhang, Xiao Ran
Critical Care.2023;[Epub] CrossRef - Obesity and 30-day case fatality after hyperglycemic crisis hospitalizations in Korea: a national cohort study
Hojun Yoon, Hyun Ho Choi, Giwoong Choi, Sun Ok Song, Kyoung Hwa Ha, Dae Jung Kim
Cardiovascular Prevention and Pharmacotherapy.2023; 5(3): 74. CrossRef - Normal‐weight central obesity and risk of cardiovascular and microvascular events in adults with prediabetes or diabetes: Chinese and British cohorts
Pingting Zhong, Shaoying Tan, Zhuoting Zhu, Ziyu Zhu, Yi Liang, Wenyong Huang, Wei Wang
Diabetes/Metabolism Research and Reviews.2023;[Epub] CrossRef - Overweight and obesity are associated with better survival inSTEMIpatients with diabetes
Hamza Chaudhry, Ramez Bodair, Ziyad Mahfoud, Soha Dargham, Jassim Al Suwaidi, Hani Jneid, Charbel Abi Khalil
Obesity.2023; 31(11): 2834. CrossRef - Poor glycaemic control: prevalence, factors and implications for the care of patients with type 2 diabetes in Kinshasa, Democratic Republic of the Congo: a cross-sectional study
Jean-Pierre Fina Lubaki, Olufemi Babatunde Omole, Joel Msafiri Francis
Frontiers in Clinical Diabetes and Healthcare.2023;[Epub] CrossRef - Comparison of obesity indices and triglyceride glucose-related parameters to predict type 2 diabetes mellitus among normal-weight elderly in China
Pan Ke, Xia Wu, Minzhi Xu, Jie Feng, Hongbin Xu, Yong Gan, Chao Wang, Zhenyu Deng, Xiang Liu, Wenning Fu, Qingfeng Tian, Yan He, Lirong Zhong, Heng Jiang, Zuxun Lu
Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity.2022; 27(3): 1181. CrossRef - Association Between Obesity and Cardiovascular Disease in Elderly Patients With Diabetes: A Retrospective Cohort Study
Sangmo Hong, Jung Hwan Park, Kyungdo Han, Chang Beom Lee, Dong Sun Kim, Sung Hoon Yu
The Journal of Clinical Endocrinology & Metabolism.2022; 107(2): e515. CrossRef - The Relationship between the Lipid Accumulation Product and Beta-cell Function in Korean Adults with or without Type 2 Diabetes Mellitus: The 2015 Korea National Health and Nutrition Examination Survey
Hye Eun Cho, Seung Bum Yang, Mi Young Gi, Ju Ae Cha, so Young Park, Hyun Yoon
Endocrine Research.2022; 47(2): 80. CrossRef - Body mass index and all-cause mortality in patients with newly diagnosed type 2 diabetes mellitus in South Korea: a retrospective cohort study
Jae-Seok Hong, Hee-Chung Kang
BMJ Open.2022; 12(4): e048784. CrossRef - Social determinants of obesity in American Indian and Alaska Native peoples aged ≥ 50 years
R Turner Goins, Cheryl Conway, Margaret Reid, Luohua Jiang, Jenny Chang, Kimberly R Huyser, Angela G Brega, John F Steiner, Amber L Fyfe-Johnson, Michelle Johnson-Jennings, Vanessa Hiratsuka, Spero M Manson, Joan O’Connell
Public Health Nutrition.2022; 25(8): 2064. CrossRef - Cardiorespiratory Fitness, BMI, Mortality, and Cardiovascular Disease in Adults with Overweight/Obesity and Type 2 Diabetes
ANDREW C. WILLS, ELSA VAZQUEZ ARREOLA, MUIDEEN T. OLAIYA, JEFFREY M. CURTIS, MARGARETA I. HELLGREN, ROBERT L. HANSON, WILLIAM C. KNOWLER
Medicine & Science in Sports & Exercise.2022; 54(6): 994. CrossRef - Spline Longitudinal Multi-response Model for the Detection of Lifestyle-
Based Changes in Blood Glucose of Diabetic Patients
Anna Islamiyati
Current Diabetes Reviews.2022;[Epub] CrossRef - The obesity paradox: Retinopathy, obesity, and circulating risk markers in youth with type 2 diabetes in the TODAY Study
Lynne L. Levitsky, Kimberly L. Drews, Morey Haymond, Rose A. Glubitosi-Klug, Lorraine E. Levitt Katz, Mihai Mititelu, William Tamborlane, Jeanie B. Tryggestad, Ruth S. Weinstock
Journal of Diabetes and its Complications.2022; 36(11): 108259. CrossRef - Distribution of lean mass and mortality risk in patients with type 2 diabetes
Li Ding, Yuxin Fan, Jingting Qiao, Jing He, Ruodan Wang, Qing He, Jingqiu Cui, Zhongshu Ma, Fangqiu Zheng, Hua Gao, Chenlin Dai, Hongyan Wei, Jun Li, Yuming Cao, Gang Hu, Ming Liu
Primary Care Diabetes.2022; 16(6): 824. CrossRef - Current Knowledge on the Pathophysiology of Lean/Normal-Weight Type 2 Diabetes
Teresa Salvatore, Raffaele Galiero, Alfredo Caturano, Luca Rinaldi, Livio Criscuolo, Anna Di Martino, Gaetana Albanese, Erica Vetrano, Christian Catalini, Celestino Sardu, Giovanni Docimo, Raffaele Marfella, Ferdinando Carlo Sasso
International Journal of Molecular Sciences.2022; 24(1): 658. CrossRef - The obesity paradox and diabetes
Giovanni Gravina, Federica Ferrari, Grazia Nebbiai
Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity.2021; 26(4): 1057. CrossRef - Implicating the effect of ketogenic diet as a preventive measure to obesity and diabetes mellitus
Sachin Kumar, Tapan Behl, Monika Sachdeva, Aayush Sehgal, Shilpa Kumari, Arun Kumar, Gagandeep Kaur, Harlokesh Narayan Yadav, Simona Bungau
Life Sciences.2021; 264: 118661. CrossRef - Diagnosis of obesity based on body composition‐associated health risks—Time for a change in paradigm
Anja Bosy‐Westphal, Manfred J. Müller
Obesity Reviews.2021;[Epub] CrossRef - Body mass index and clinical outcomes in patients with intracerebral haemorrhage: results from the China Stroke Center Alliance
Zhentang Cao, Xinmin Liu, Zixiao Li, Hongqiu Gu, Yingyu Jiang, Xingquan Zhao, Yongjun Wang
Stroke and Vascular Neurology.2021; 6(3): 424. CrossRef - Obesity and Overweight Are Associated with Minimal Extrathyroidal Extension, Multifocality and Bilaterality of Papillary Thyroid Cancer
Krzysztof Kaliszewski, Dorota Diakowska, Marta Rzeszutko, Jerzy Rudnicki
Journal of Clinical Medicine.2021; 10(5): 970. CrossRef - Obesity paradox in patients with cardiovascular diseases and diabetes mellitus type 2 (analytical review)
Margarita P. Zaikina, Valentina A. Kapustina, Stanislav I. Savel'ev
HEALTH CARE OF THE RUSSIAN FEDERATION.2021; 65(2): 135. CrossRef - Risk factors for adverse outcomes among 35 879 veterans with and without diabetes after diagnosis with COVID-19
Pandora L Wander, Elliott Lowy, Lauren A Beste, Luis Tulloch-Palomino, Anna Korpak, Alexander C Peterson, Bessie A Young, Edward J Boyko
BMJ Open Diabetes Research & Care.2021; 9(1): e002252. CrossRef - Obesity and glycemic control among people with type 2 diabetes in the United States: A retrospective cohort study using insurance claims data
Kristina S. Boye, Maureen J. Lage, Vivian Thieu, Shraddha Shinde, Shivanie Dhamija, Jay Patrick Bae
Journal of Diabetes and its Complications.2021; 35(9): 107975. CrossRef - Differential effects of body mass index on domain-specific cognitive outcomes after stroke
Minwoo Lee, Mi Sun Oh, San Jung, Ju-Hun Lee, Chul-Ho Kim, Min Uk Jang, Young Eun Kim, Hee-Joon Bae, Jaeseol Park, Yeonwook Kang, Byung-Chul Lee, Jae-Sung Lim, Kyung-Ho Yu
Scientific Reports.2021;[Epub] CrossRef - Associations between traditional and non-traditional anthropometric indices and cardiometabolic risk factors among inpatients with type 2 diabetes mellitus: a cross-sectional study
Sahar Golabi, Sajad Ajloo, Fatemeh Maghsoudi, Maryam Adelipour, Mahshid Naghashpour
Journal of International Medical Research.2021;[Epub] CrossRef - Impact of preexisting type 2 diabetes mellitus and antidiabetic drugs on all-cause and cause-specific mortality among Medicaid-insured women diagnosed with breast cancer
Wayne R. Lawrence, Akiko S. Hosler, Margaret Gates Kuliszewski, Matthew C. Leinung, Xiuling Zhang, Maria J. Schymura, Francis P. Boscoe
Cancer Epidemiology.2020; 66: 101710. CrossRef - Serum Adiponectin and Progranulin Level in Patients with Benign Thyroid Nodule or Papillary Thyroid Cancer
Hyemi Kwon, Se Eun Park, Ji-Sup Yun, Cheol-Young Park
Endocrinology and Metabolism.2020; 35(2): 396. CrossRef - Obesity, sleep apnea, and cancer
Isaac Almendros, Miguel A. Martinez-Garcia, Ramon Farré, David Gozal
International Journal of Obesity.2020; 44(8): 1653. CrossRef - Association of Body Mass Index With Clinical Outcomes in Patients With Atrial Fibrillation: A Report From the FANTASIIA Registry
Vicente Bertomeu‐Gonzalez, José Moreno‐Arribas, María Asunción Esteve‐Pastor, Inmaculada Roldán‐Rabadán, Javier Muñiz, Paula Raña‐Míguez, Martín Ruiz‐Ortiz, Ángel Cequier, Vicente Bertomeu‐Martínez, Lina Badimón, Manuel Anguita, Gregory Y. H. Lip, Francis
Journal of the American Heart Association.2020;[Epub] CrossRef - Risk of type 2 diabetes according to the cumulative exposure to metabolic syndrome or obesity: A nationwide population‐based study
You‐Bin Lee, Da Hye Kim, Seon Mee Kim, Nan Hee Kim, Kyung Mook Choi, Sei Hyun Baik, Yong Gyu Park, Kyungdo Han, Hye Jin Yoo
Journal of Diabetes Investigation.2020; 11(6): 1583. CrossRef - Gut microbiota of obese and diabetic Thai subjects and interplay with dietary habits and blood profiles
Lucsame Gruneck, Niwed Kullawong, Kongkiat Kespechara, Siam Popluechai
PeerJ.2020; 8: e9622. CrossRef Multistate Models to Predict Development of Late Complications of Type 2 Diabetes in an Open Cohort Study
Roqayeh Aliyari, Ebrahim Hajizadeh, Ashraf Aminorroaya, Farshad Sharifi, Iraj Kazemi, Ahmad-Reza Baghestani
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2020; Volume 13: 1863. CrossRef- Early weaning induces short‐ and long‐term effects on pancreatic islets in Wistar rats of both sexes
Carla Bruna Pietrobon, Rosiane Aparecida Miranda, Iala Milene Bertasso, Paulo Cezar de Freitas Mathias, Maria Lúcia Bonfleur, Sandra Lucinei Balbo, Marise Auxiliadora de Barros Reis, Márcia Queiroz Latorraca, Vanessa Cristina Arantes, Elaine de Oliveira,
The Journal of Physiology.2020; 598(3): 489. CrossRef - A negative impact of recent weight loss on in-hospital mortality is not modified by overweight and obesity
Rocco Barazzoni, Isabella Sulz, Karin Schindler, Stephan C. Bischoff, Gianluca Gortan Cappellari, Michael Hiesmayr
Clinical Nutrition.2020; 39(8): 2510. CrossRef - Body mass index and mortality among middle-aged Japanese individuals with diagnosed diabetes: The Japan Public Health Center-based prospective study (JPHC study)
Chiho Yamazaki, Atsushi Goto, Motoki Iwasaki, Norie Sawada, Shino Oba, Mitsuhiko Noda, Hiroyasu Iso, Hiroshi Koyama, Shoichiro Tsugane
Diabetes Research and Clinical Practice.2020; 164: 108198. CrossRef Is the Obesity Paradox in Type 2 Diabetes Due to Artefacts of Biases? An Analysis of Pooled Cohort Data from the Heinz Nixdorf Recall Study and the Study of Health in Pomerania
Bernd Kowall, Andreas Stang, Raimund Erbel, Susanne Moebus, Astrid Petersmann, Antje Steveling, Karl-Heinz Jöckel, Henry Völzke
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2020; Volume 13: 1989. CrossRef- Associations between BMI, waist circumference, central obesity and outcomes in type II diabetes mellitus: The ACCORD Trial
Charles A. German, Brian Laughey, Alain G. Bertoni, Joseph Yeboah
Journal of Diabetes and its Complications.2020; 34(3): 107499. CrossRef - Trends in mechanical ventilation use and mortality over time in patients receiving mechanical ventilation in Spain from 2001 to 2015.
Javier de-Miguel-Díez, Rodrigo Jiménez-García, Valentín Hernández-Barrera, Jose J Zamorano-Leon, Rosa Villanueva-Orbaiz, Romana Albaladejo-Vicente, Ana López-de-Andrés
European Journal of Internal Medicine.2020; 74: 67. CrossRef - Type 2 diabetes mellitus: pathogenesis and genetic diagnosis
D. Himanshu, Wahid Ali, Mohd Wamique
Journal of Diabetes & Metabolic Disorders.2020; 19(2): 1959. CrossRef - Prevalence and factors associated with overweight and obesity among patients with type 2 diabetes mellitus in Uganda—a descriptive retrospective study
Salome Tino, Billy N Mayanja, Michael Charles Mubiru, Emmanuel Eling, Edward Ddumba, Pontiano Kaleebu, Moffat Nyirenda
BMJ Open.2020; 10(11): e039258. CrossRef - Nutrition Therapy in Critically Ill Overweight Elderly Patient with Heart Failure, Myocardial Infarction, Pneumonia, and Chronic Kidney Disease
Christina RUSLI, Agussalim BUKHARI, Nurpudji A. TASLIM, Suryani AS’AD, Haerani RASYID
Journal of Nutritional Science and Vitaminology.2020; 66(Supplement): S25. CrossRef - Obesity and childhood asthma
Jason E. Lang
Current Opinion in Pulmonary Medicine.2019; 25(1): 34. CrossRef - Why primary obesity is a disease?
Antonino De Lorenzo, Santo Gratteri, Paola Gualtieri, Andrea Cammarano, Pierfrancesco Bertucci, Laura Di Renzo
Journal of Translational Medicine.2019;[Epub] CrossRef - Impaired compensatory hyperinsulinemia among nonobese type 2 diabetes patients: a cross-sectional study
Jit Sarkar, Sujay Krishna Maity, Abhishek Sen, Titli Nargis, Dipika Ray, Partha Chakrabarti
Therapeutic Advances in Endocrinology and Metabolism.2019;[Epub] CrossRef - Sedentary behaviour is associated with diabetes mellitus in adults: findings of a cross-sectional analysis from the Brazilian National Health System
Ítalo Ribeiro Lemes, Xuemei Sui, Bruna Camilo Turi-Lynch, Duck-chul Lee, Steven N Blair, Rômulo Araújo Fernandes, Jamile Sanches Codogno, Henrique Luiz Monteiro
Journal of Public Health.2019; 41(4): 742. CrossRef - Obesity Paradox in Chronic Liver Diseases: Product of Bias or a Real Thing?
Ines Bilic Curcic, Maja Cigrovski Berkovic, Lucija Kuna, Hrvoje Roguljic, Robert Smolic, Silvija Canecki Varzic, Lucija Virovic Jukic, Martina Smolic
Journal of Clinical and Translational Hepatology.2019; 7(3): 1. CrossRef - From the Obesity Tsunami to the Diabetes Avalanche: Primordial Prevention of the Diabesity-Related Cardiovascular Epidemic by Diabeto-Cardiologists
Mustafa Karakurt, Burak Acar, Ozcan Ozeke, Mustafa Bilal Ozbay, Yasin Ozen, Sefa Unal, Mustafa Karanfil, Cagri Yayla, Serkan Cay, Orhan Maden, Dursun Aras, Serkan Topaloglu, Sinan Aydogdu, Zehra Golbasi
Angiology.2019; 70(4): 371. CrossRef - Increased Plasma Dipeptidyl Peptidase-4 (DPP4) Activity Is an Obesity-Independent Parameter for Glycemic Deregulation in Type 2 Diabetes Patients
Jit Sarkar, Titli Nargis, Om Tantia, Sujoy Ghosh, Partha Chakrabarti
Frontiers in Endocrinology.2019;[Epub] CrossRef - INVESTIGATING INDIVIDUAL FACTORS RELATED TO READMISSION OF PATIENTS WITH TYPE 2 DIABETES- A CROSS-SECTIONAL STUDY
Valiallah Dashtpour, Mehran Hesaraki, Mahnaz Abavisani, Mahdieh Sari, Sudabeh Ahmadidarrehsima
Journal of Evolution of Medical and Dental Sciences.2018; 7(53): 5604. CrossRef
- Epidemiology
- Predictors of Incident Type 2 Diabetes Mellitus in Japanese Americans with Normal Fasting Glucose Level
-
You-Cheol Hwang, Wilfred Y. Fujimoto, Steven E. Kahn, Donna L. Leonetti, Edward J. Boyko
-
Diabetes Metab J. 2018;42(3):198-206. Published online April 25, 2018
-
DOI: https://doi.org/10.4093/dmj.2017.0100
-
-
4,048
View
-
34
Download
-
5
Web of Science
-
3
Crossref
-
Abstract
PDFPubReader
- Background
Little is known about the natural course of normal fasting glucose (NFG) in Asians and the risk factors for future diabetes. MethodsA total of 370 Japanese Americans (163 men, 207 women) with NFG levels and no history of diabetes, aged 34 to 75 years, were enrolled. Oral glucose tolerance tests were performed at baseline, 2.5, 5, and 10 years after enrollment. ResultsDuring 10 years of follow-up, 16.1% of participants met criteria for diabetes diagnosis, and 39.6% of subjects still had NFG levels at the time of diabetes diagnosis. During 5 years of follow-up, age (odds ratio [OR], 1.05; 95% confidence interval [CI], 1.01 to 1.10; P=0.026) and family history of diabetes (OR, 3.24; 95% CI, 1.42 to 7.40; P=0.005) were independently associated with future diabetes diagnosis; however, fasting glucose level was not an independent predictor. During 10 years of follow-up, family history of diabetes (OR, 2.76; 95% CI, 1.37 to 5.54; P=0.004), fasting insulin level (OR, 1.01; 95% CI, 1.00 to 1.02; P=0.037), and fasting glucose level (OR, 3.69; 95% CI, 1.13 to 12.01; P=0.030) were associated with diabetes diagnosis independent of conventional risk factors for diabetes. ConclusionA substantial number of subjects with NFG at baseline still remained in the NFG range at the time of diabetes diagnosis. A family history of diabetes and fasting insulin and glucose levels were associated with diabetes diagnosis during 10 years of follow-up; however, fasting glucose level was not associated with diabetes risk within the relatively short-term follow-up period of 5 years in subjects with NFG.
-
Citations
Citations to this article as recorded by - J-shape relationship between normal fasting plasma glucose and risk of type 2 diabetes in the general population: results from two cohort studies
Linfeng He, Wenbin Zheng, Zeyu Li, Lu Chen, Wen Kong, Tianshu Zeng
Journal of Translational Medicine.2023;[Epub] CrossRef - Fasting plasma glucose and risk of type 2 diabetes mellitus in a group of Chinese people with normoglycemia and without obesity
Ziqiong Wang, Zheng Liu, Sen He
Journal of Diabetes.2021; 13(7): 601. CrossRef - Hidden Risks behind Normal Fasting Glucose: Is It Significant?
Seung-Hwan Lee
Diabetes & Metabolism Journal.2018; 42(3): 196. CrossRef
|
KDA
