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Dong Won Byun  (Byun DW) 1 Article
Complications
Association between Serum Cystatin C and Vascular Complications in Type 2 Diabetes Mellitus without Nephropathy
Hye Jeong Kim, Dong Won Byun, Kyoil Suh, Myung Hi Yoo, Hyeong Kyu Park
Diabetes Metab J. 2018;42(6):513-518.   Published online October 15, 2018
DOI: https://doi.org/10.4093/dmj.2018.0006
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  • 12 Web of Science
  • 10 Crossref
AbstractAbstract PDFPubReader   
Background

Recent studies have correlated serum cystatin C (CysC) with vascular complications, but few studies have investigated this correlation in diabetes patients without nephropathy. This study aimed to evaluate if higher serum CysC levels increase the risk for vascular complications in type 2 diabetes mellitus patients with normal renal function or mild renal impairment.

Methods

A total of 806 consecutive patients with type 2 diabetes mellitus who were admitted to the diabetes center of Soonchunhyang University Hospital for blood glucose control were retrospectively reviewed. Patients with nephropathy were excluded. Subjects were categorized into quartiles of serum CysC levels (Q1, ≤0.65 mg/L; Q2, 0.66 to 0.79 mg/L; Q3, 0.80 to 0.94 mg/L; and Q4, ≥0.95 mg/L).

Results

The proportion of patients with diabetic retinopathy (DR) (P for trend <0.001), coronary heart disease (CHD) (P for trend <0.001), and stroke (P for trend <0.001) increased across the serum CysC quartiles. After adjustment for confounding factors, the highest serum CysC level remained a significant risk factor for DR (odds ratio [OR], 1.929; 95% confidence interval [CI], 1.007 to 4.144; P=0.040). Compared with Q1, a significant positive association was observed between serum CysC and CHD in Q2 (OR, 7.321; 95% CI, 1.114 to 48.114; P=0.012), Q3 (OR, 6.027; 95% CI, 0.952 to 38.161; P=0.020), and Q4 (OR, 8.122; 95% CI, 1.258 to 52.453; P=0.007). No associations were observed between CysC and stroke after additional adjustment for confounding variables.

Conclusion

Serum CysC levels are independently associated with DR and CHD, suggesting that CysC may be useful for identifying type 2 diabetes mellitus patients without nephropathy who are at high risk for vascular complications.

Citations

Citations to this article as recorded by  
  • Association of Estimated Glomerular Filtration Rate Trajectories with Atrial Fibrillation Risk in Populations with Normal or Mildly Impaired Renal Function
    Chi Wang, Qian Xin, Junjuan Li, Jianli Wang, Siyu Yao, Miao Wang, Maoxiang Zhao, Shuohua Chen, Shouling Wu, Hao Xue
    Kidney Diseases.2024; : 1.     CrossRef
  • A systematic literature review of machine learning based risk prediction models for diabetic retinopathy progression
    Tiwalade Modupe Usman, Yakub Kayode Saheed, Augustine Nsang, Abel Ajibesin, Sandip Rakshit
    Artificial Intelligence in Medicine.2023; 143: 102617.     CrossRef
  • Serum cystatin C for risk stratification of prediabetes and diabetes populations
    Kun Xiong, Shiran Zhang, Pingting Zhong, Zhuoting Zhu, Yanping Chen, Wenyong Huang, Wei Wang
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2023; 17(11): 102882.     CrossRef
  • Serum VEGF, high-sensitivity CRP, and cystatin-C assist in the diagnosis of type 2 diabetic retinopathy complicated with hyperuricemia
    Jing Wei, Jincheng Zhang, Yanan Shi, Huiqin Zhang, Yan Wu
    Open Medicine.2023;[Epub]     CrossRef
  • Diagnostic circulating biomarkers to detect vision‐threatening diabetic retinopathy: Potential screening tool of the future?
    Karen Frudd, Sobha Sivaprasad, Rajiv Raman, Subramanian Krishnakumar, Yeddula Rebecca Revathy, Patric Turowski
    Acta Ophthalmologica.2022;[Epub]     CrossRef
  • Association between circulating cystatin C and hyperuricemia: a cross-sectional study
    Yanjun Guo, Hangkai Huang, Yishu Chen, Chao Shen, Chengfu Xu
    Clinical Rheumatology.2022; 41(7): 2143.     CrossRef
  • Multicenter Evaluation of Diagnostic Circulating Biomarkers to Detect Sight-Threatening Diabetic Retinopathy
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    JAMA Ophthalmology.2022; 140(6): 587.     CrossRef
  • A Cross-Sectional Study of Serum and Urine Fluoride in Diabetes in Fluoride Exposed Population
    Sai Deepika Ram Mohan, Shashidhar Kurpad Nagaraj, Raveesha Anjanappa, Muninarayana Chandrappa
    Journal of Evolution of Medical and Dental Sciences.2021; 10(11): 798.     CrossRef
  • Cystatin C predicts the risk of incident cerebrovascular disease in the elderly
    Xin Zheng, Hong-da She, Qiao-xin Zhang, Tong Si, Ku-sheng Wu, Ying-xiu Xiao
    Medicine.2021; 100(28): e26617.     CrossRef
  • Proteinuria Is Associated with Carotid Artery Atherosclerosis in Non-Albuminuric Type 2 Diabetes: A Cross-Sectional Study
    Jaehyun Bae, Yong-ho Lee, Eun Seok Kang, Bong-Soo Cha, Byung-Wan Lee
    Journal of Clinical Medicine.2020; 9(1): 136.     CrossRef

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