- Changes in Adenosine Deaminase Activity in Patients with Type 2 Diabetes Mellitus and Effect of DPP-4 Inhibitor Treatment on ADA Activity
-
Jae-Geun Lee, Dong Gu Kang, Jung Re Yu, Youngree Kim, Jinsoek Kim, Gwanpyo Koh, Daeho Lee
-
Diabetes Metab J. 2011;35(2):149-158. Published online April 30, 2011
-
DOI: https://doi.org/10.4093/dmj.2011.35.2.149
-
-
5,139
View
-
40
Download
-
28
Crossref
-
Abstract
PDFPubReader
- Background
Dipeptidyl peptidase 4 (DPP-4, also known as CD26) binds with adenosine deaminase (ADA) to activate T lymphocytes. Here, we investigated whether ADA activity is specifically affected by treatment with DPP-4 inhibitor (DPP4I) compared with other anti-diabetic agents. MethodsFasting ADA activity, in addition to various metabolic and biochemical parameters, were measured in 262 type 2 diabetes mellitus (T2DM) patients taking various anti-diabetic agents and in 46 non-diabetic control subjects. ResultsADA activity was increased in T2DM patients compared with that in non-diabetic control subjects (mean±standard error, 23.1±0.6 U/L vs. 18.6±0.8 U/L; P<0.05). ADA activity was correlated with fasting plasma glucose (r=0.258, P<0.05), HbA1c (r=0.208, P<0.05), aspartate aminotransferase (r=0.325, P<0.05), and alanine aminotransferase (r=0.248, P<0.05). Compared with the well-controlled T2DM patients (HbA1c<7%), the poorly controlled group (HbA1c>9%) showed significantly increased ADA activity (21.1±0.8 U/L vs. 25.4±1.6 U/L; P<0.05). The effect of DPP4I on ADA activity in T2DM patients did not differ from those of other oral anti-diabetic agents or insulin. T2DM patients on metformin monotherapy showed a lower ADA activity (20.9±1.0 U/L vs. 28.1±2.8 U/L; P<0.05) compared with that of those on sulfonylurea monotherapy. ConclusionOur results show that ADA activity is increased in T2DM patients compared to that in non-diabetic patients, is positively correlated with blood glucose level, and that DPP4I has no additional specific effect on ADA activity, except for a glycemic control- or HbA1c-dependent effect.
-
Citations
Citations to this article as recorded by
- Influence of BMI on adenosine deaminase and stroke outcomes in mechanical thrombectomy subjects
Benton Maglinger, Christopher J. McLouth, Jacqueline A. Frank, Chintan Rupareliya, Madison Sands, Lila Sheikhi, Shivani Pahwa, David Dornbos, Jordan P. Harp, Amanda L. Trout, Jadwiga Turchan-Cholewo, Ann M. Stowe, Justin F. Fraser, Keith R. Pennypacker Brain, Behavior, & Immunity - Health.2022; 20: 100422. CrossRef - Glutamine restores testicular glutathione-dependent antioxidant defense and upregulates NO/cGMP signaling in sleep deprivation-induced reproductive dysfunction in rats
M.A. Hamed, T.M. Akhigbe, R.E. Akhigbe, A.O. Aremu, P.A. Oyedokun, J.A. Gbadamosi, P.E. Anifowose, M.A. Adewole, O.O. Aboyeji, H.O. Yisau, G.O. Tajudeen, M.M. Titiloye, N.F. Ayinla, A.F. Ajayi Biomedicine & Pharmacotherapy.2022; 148: 112765. CrossRef - Effects of quercetin and metabolites on uric acid biosynthesis and consequences for gene expression in the endothelium
Sarka Tumova, Yuanlu Shi, Ian M. Carr, Gary Williamson Free Radical Biology and Medicine.2021; 162: 191. CrossRef - The value of adenosine deaminase activity in latent autoimmune diabetes in adults and type 2 diabetes patients
Yu Zhou, Wei-Dong Jin, Zhen-Zhen Pang, Jun Xia, Su-Feng Chen International Journal of Diabetes in Developing Countries.2021; 41(1): 48. CrossRef - Purinergic signaling in diabetes and metabolism
Shanu Jain, Kenneth A. Jacobson Biochemical Pharmacology.2021; 187: 114393. CrossRef - Berberine modulates crucial erectogenic biomolecules and alters histological architecture in penile tissues of diabetic rats
Stephen Adeniyi Adefegha, Ganiyu Oboh, Felix Abayomi Dada, Sunday Idowu Oyeleye, Bathlomew Maduka Okeke Andrologia.2021;[Epub] CrossRef - Suppression of uric acid and lactate production by sodium acetate ameliorates hepatic triglyceride accumulation in fructose-insulin resistant pregnant rats
Adewumi O. Oyabambi, Kehinde S. Olaniyi, Ayodele O. Soladoye, Lawrence A. Olatunji Environmental Toxicology and Pharmacology.2020; 80: 103452. CrossRef - Therapeutic Perspectives of Adenosine Deaminase Inhibition in Cardiovascular Diseases
Barbara Kutryb-Zajac, Paulina Mierzejewska, Ewa M. Slominska, Ryszard T. Smolenski Molecules.2020; 25(20): 4652. CrossRef - Adenosine as a Marker and Mediator of Cardiovascular Homeostasis: A Translational Perspective
Trevor Simard, Richard Jung, Alisha Labinaz, Mohammad Ali Faraz, F. Daniel Ramirez, Pietro Di Santo, Ian Pitcher, Pouya Motazedian, Chantal Gaudet, Rebecca Rochman, Jeffrey Marbach, Paul Boland, Kiran Sarathy, Saleh Alghofaili, Juan J. Russo, Etienne Cout Cardiovascular & Hematological Disorders-Drug Targets.2019; 19(2): 109. CrossRef - Mineralocorticoid receptor blockade attenuates disrupted glutathione-dependent antioxidant defense and elevated endoglin in the hearts of pregnant rats exposed to testosterone
Taofeek O. Usman, Olufunto O. Badmus, InKyeom Kim, Lawrence A. Olatunji Naunyn-Schmiedeberg's Archives of Pharmacology.2019; 392(7): 773. CrossRef - Serum activities of dipeptidyl peptidase-4 and adenosine deaminase in polycystic ovary syndrome: association with obesity
Seda Kahraman, Alev Eroglu Altinova, Serenay Elgun, Mehmet Muhittin Yalcin, Banu Aktas Yilmaz, Cigdem Ozkan, Mujde Akturk, Fusun Balos Toruner Gynecological Endocrinology.2019; 35(8): 714. CrossRef - Serum adenosine deaminase activity and coronary artery disease: a retrospective case-control study based on 9929 participants
Chao Xuan, Qing-Wu Tian, Shao-Yan Zhang, Hui Li, Ting-Ting Tian, Peng Zhao, Kang Yue, Yan-Yan Ling, Guo-Wei He, Li-Min Lun Therapeutic Advances in Chronic Disease.2019;[Epub] CrossRef - Metabolites related to purine catabolism and risk of type 2 diabetes incidence; modifying effects of the TCF7L2-rs7903146 polymorphism
Christopher Papandreou, Jun Li, Liming Liang, Mònica Bulló, Yan Zheng, Miguel Ruiz-Canela, Edward Yu, Marta Guasch-Ferré, Cristina Razquin, Clary Clish, Dolores Corella, Ramon Estruch, Emilio Ros, Montserrat Fitó, Fernando Arós, Lluís Serra-Majem, Nuria R Scientific Reports.2019;[Epub] CrossRef - Current status of G-protein coupled receptors as potential targets against type 2 diabetes mellitus
Mehboob Hoque, Safdar Ali, Muddasarul Hoda International Journal of Biological Macromolecules.2018; 118: 2237. CrossRef - Endoglin inhibition by sodium acetate and flutamide ameliorates cardiac defective G6PD-dependent antioxidant defense in gestational testosterone-exposed rats
Lawrence A. Olatunji, Emmanuel D. Areola, Olufunto O. Badmus Biomedicine & Pharmacotherapy.2018; 107: 1641. CrossRef - Sodium acetate and androgen receptor blockade improve gestational androgen excess-induced deteriorated glucose homeostasis and antioxidant defenses in rats: roles of adenosine deaminase and xanthine oxidase activities
Taofeek O. Usman, Emmanuel D. Areola, Olufunto O. Badmus, InKyeom Kim, Lawrence A. Olatunji The Journal of Nutritional Biochemistry.2018; 62: 65. CrossRef - ADENOSINE DEAMINASE ACTIVITY IN TYPE 2 DIABETES MELLITUS
Farija Peruvankuzhiyil, Lavanya Madhavan, Manaloor George Joseraj Journal of Evidence Based Medicine and Healthcare.2017; 4(5): 238. CrossRef - Adenosine signaling in diabetes mellitus and associated cardiovascular and renal complications
Maria Peleli, Mattias Carlstrom Molecular Aspects of Medicine.2017; 55: 62. CrossRef - The Adenosinergic System in Diabetic Retinopathy
J. Vindeirinho, A. R. Santiago, C. Cavadas, A. F. Ambrósio, P. F. Santos Journal of Diabetes Research.2016; 2016: 1. CrossRef - Upregulation of inducible NO synthase by exogenous adenosine in vascular smooth muscle cells activated by inflammatory stimuli in experimental diabetes
Alberto Nassi, Francesca Malorgio, Serena Tedesco, Andrea Cignarella, Rosa Maria Gaion Cardiovascular Diabetology.2016;[Epub] CrossRef - Reduced adenosine A2a receptor–mediated efferent arteriolar vasodilation contributes to diabetes-induced glomerular hyperfiltration
Patrik Persson, Peter Hansell, Fredrik Palm Kidney International.2015; 87(1): 109. CrossRef - CD26/DPP4 Levels in Peripheral Blood and T Cells in Patients With Type 2 Diabetes Mellitus
Sang Ah Lee, Young Ree Kim, Eun Jin Yang, Eun-Jeong Kwon, Sun Hyung Kim, Sung Ha Kang, Doek Bae Park, Byung-Chul Oh, Jinseok Kim, Sang Taek Heo, Gwanpyo Koh, Dae Ho Lee The Journal of Clinical Endocrinology & Metabolism.2013; 98(6): 2553. CrossRef - Raised Serum Adenosine Deaminase Level in Nonobese Type 2 Diabetes Mellitus
Vineet Kumar Khemka, Debajit Bagchi, Arindam Ghosh, Oishimaya Sen, Aritri Bir, Sasanka Chakrabarti, Anindita Banerjee, R. E. Felberbaum, V. Sánchez-Margalet, S. Ulisse The Scientific World Journal.2013;[Epub] CrossRef - Phosphodiesterase III Inhibition Increases cAMP Levels and Augments the Infarct Size Limiting Effect of a DPP-4 Inhibitor in Mice with Type-2 Diabetes Mellitus
Yochai Birnbaum, Alexander C. Castillo, Jinqiao Qian, Shukuan Ling, Hongmei Ye, Jose R. Perez-Polo, Mandeep Bajaj, Yumei Ye Cardiovascular Drugs and Therapy.2012; 26(6): 445. CrossRef - Serum Adenosine deaminase activity in type 2 Diabetes Mellitus patients
M. N. Vanitha Gowda, K. C. Vasudha, S. Reshma, K. J. Sujatha International Journal of Diabetes in Developing Countries.2012; 32(3): 176. CrossRef - Cyclic AMP and PKA: How can a Lot of Good Come from the Potentially Bad?
Barbara Huisamen Cardiovascular Drugs and Therapy.2012; 26(6): 435. CrossRef - Gadd45α: A Novel Diabetes-Associated Gene Potentially Linking Diabetic Cardiomyopathy and Baroreflex Dysfunction
Ning Wang, Chao Yang, Fang Xie, Lihua Sun, Xiaolin Su, Ying Wang, Ran Wei, Rong Zhang, Xia Li, Baofeng Yang, Jing Ai, Rajesh Gopalrao Katare PLoS ONE.2012; 7(12): e49077. CrossRef - The CD39-Adenosinergic Axis in the Pathogenesis of Immune and Nonimmune Diabetes
Joanne S. J. Chia, Jennifer L. McRae, Peter J. Cowan, Karen M. Dwyer Journal of Biomedicine and Biotechnology.2012; 2012: 1. CrossRef
- Clinical Characteristics of Type 2 Diabetes Patients according to Family History of Diabetes
-
Seung Uk Jeong, Dong Gu Kang, Dae Ho Lee, Kang Woo Lee, Dong-Mee Lim, Byung Joon Kim, Keun-Yong Park, Hyoun-Jung Chin, Gwanpyo Koh
-
Korean Diabetes J. 2010;34(4):222-228. Published online August 31, 2010
-
DOI: https://doi.org/10.4093/kdj.2010.34.4.222
-
-
4,276
View
-
30
Download
-
17
Crossref
-
Abstract
PDFPubReader
- Background
Type 2 diabetes mellitus (T2DM) has a strong genetic component, and its prevalence is notably increased in the family members of T2DM patients. However, there are few studies about the family history of T2DM. We carried out this study to assess the influences of family history on clinical characteristics in T2DM patients. MethodsThis is a cross-sectional study involving 651 T2DM patients. Patient history and physical examination were performed and fasting blood was taken. If any first degree relative was diabetic, a family history of diabetes was considered to exist. ResultsAmong the total 621 patients, 38.4% had a family history of diabetes. Patients with a family history had a younger age, higher weight, younger age at diagnosis and higher triglyceride level than did those without a family history. Dyslipidemia medication and metabolic syndrome were more prevalent in familial diabetes. Sex, blood pressure, previous treatment for diabetes, HbA1c, C-peptide, total cholesterol, high density lipoprotein cholesterol, and low density lipoprotein cholesterol were not different between familial and non-familial diabetes. Upon multiple linear regression analysis, the family history of diabetes remained significantly associated with serum triglyceride level. ConclusionIn T2DM patients with a family history of diabetes, the disease tended to develop earlier. Metabolic syndrome and cardiovascular risk factors are more prevalent in familial T2DM than they were in non-familial T2DM. These results support the necessity of earlier screening for diabetes in family members of T2DM patients and more active prevention against cardiovascular disease in T2DM patients with a family history.
-
Citations
Citations to this article as recorded by
- COVID-19-Induced Diabetes Mellitus: Comprehensive Cellular and Molecular Mechanistic Insights
Praise Tatenda Nhau, Mlindeli Gamede, Ntethelelo Sibiya Pathophysiology.2024; 31(2): 197. CrossRef - Positive parental history of diabetes is associated with early diagnosis, better dietary compliance, and glycemic control among type 2 diabetes patients in southern Sri Lanka
Warsha De Zoysa, Thilak Priyantha Weerarathna, Keddagoda Gamage Piyumi Wasana, Miyuru Kavinda Weerarathna, Vidarsha Senadeera Diabetology & Metabolic Syndrome.2024;[Epub] CrossRef - Effects of Propolis Consumption on Glycemic Indices and Liver Enzymes in Adults: A Grading of Recommendations Assessment, Development, and Valuation-assessed Systematic Review and Dose-Response Meta-analysis
Shaghayegh Adeli, Mahsa Maroofi, Fatemeh Pourteymour Fard Tabrizi, Beitullah Alipour, Marzieh Heidari, Mahdi Vajdi, Mahdieh Abbasalizad-Farhangi Clinical Therapeutics.2024; 46(9): e6. CrossRef - Evolutionary algorithm for the optimization of meal intake and insulin administration in patients with type 2 diabetes
Eva Gonzalez-Flo, Elaheh Kheirabadi, Carlos Rodriguez-Caso, Javier Macía Frontiers in Physiology.2023;[Epub] CrossRef - Role of Cytokines (IL-17 and IL-33), FGF-18, and WNT-5 in the Pathogenesis of Patients with Established Type II Diabetes
Przha Mohammed, Kawa Amin Journal of Zankoy Sulaimani - Part A.2023; 25(2): 11. CrossRef - Cellular Chitchatting: Exploring the Role of Exosomes as Cardiovascular Risk Factors
Giulia Germena, Laura Cecilia Zelarayán, Rabea Hinkel Frontiers in Cell and Developmental Biology.2022;[Epub] CrossRef - Combined associations of family history and self-management with age at diagnosis and cardiometabolic risk in 86,931 patients with type 2 diabetes: Joint Asia Diabetes Evaluation (JADE) Register from 11 countries
Johnny T. K. Cheung, Eric Lau, Cyrus C. T. Tsui, Edmond L. N. Siu, Naomi K. W. Tse, Nicole Y. L. Hui, Ronald C. W. Ma, Alice P. S. Kong, Amy Fu, Vanessa Lau, Weiping Jia, Wayne H. H. Sheu, Leorino Sobrepena, K. H. Yoon, Alexander T. B. Tan, Yook-Chin Chia BMC Medicine.2022;[Epub] CrossRef - Capsaicin, its clinical significance in patients with painful diabetic neuropathy
Phiwayinkosi V. Dludla, Bongani B. Nkambule, Ilenia Cirilli, Fabio Marcheggiani, Sihle E. Mabhida, Khanyisani Ziqubu, Yonela Ntamo, Babalwa Jack, Tawanda M. Nyambuya, Sidney Hanser, Sithandiwe E. Mazibuko-Mbeje Biomedicine & Pharmacotherapy.2022; 153: 113439. CrossRef - Safety profile of sodium glucose co-transporter 2 (SGLT2) inhibitors: A brief summary
Annamaria Mascolo, Raffaella Di Napoli, Nunzia Balzano, Donato Cappetta, Konrad Urbanek, Antonella De Angelis, Lucia Scisciola, Irene Di Meo, Maria Giuseppa Sullo, Concetta Rafaniello, Liberata Sportiello Frontiers in Cardiovascular Medicine.2022;[Epub] CrossRef - Impact of triglycerides and waist circumference on insulin resistance and β-cell function in non-diabetic first-degree relatives of type 2 diabetes
Fahd Ahmed, Molham AL-Habori, Ebtesam Al-Zabedi, Riyadh Saif-Ali BMC Endocrine Disorders.2021;[Epub] CrossRef - Orientin Improves Substrate Utilization and the Expression of Major Genes Involved in Insulin Signaling and Energy Regulation in Cultured Insulin-Resistant Liver Cells
Sithandiwe E. Mazibuko-Mbeje, Sinenhlanhla X. H. Mthembu, Andani Tshiitamune, Ndivhuwo Muvhulawa, Fikile T. Mthiyane, Khanyisani Ziqubu, Christo J. F. Muller, Phiwayinkosi V. Dludla Molecules.2021; 26(20): 6154. CrossRef - Identification of Pre-Diabetic Biomarkers in the Progression of Diabetes Mellitus
Jae-Ho Lee, Do-Young Kim, Rubee Pantha, Eun-Ho Lee, Jae-Hoon Bae, Eugene Han, Dae-Kyu Song, Taeg Kyu Kwon, Seung-Soon Im Biomedicines.2021; 10(1): 72. CrossRef - Shared (epi)genomic background connecting neurodegenerative diseases and type 2 diabetes
Valerio Caputo, Andrea Termine, Claudia Strafella, Emiliano Giardina, Raffaella Cascella World Journal of Diabetes.2020; 11(5): 155. CrossRef - Family history of diabetes in both parents is strongly associated with impaired residual β‐cell function in Japanese type 2 diabetes patients
Minoru Iwata, Yutaka Kamura, Hisae Honoki, Kaori Kobayashi, Manabu Ishiki, Kunimasa Yagi, Yasuo Fukushima, Atsuko Takano, Hiromi Kato, Shihou Murakami, Kiyohiro Higuchi, Chikaaki Kobashi, Kazuhito Fukuda, Yukiko Koshimizu, Kazuyuki Tobe Journal of Diabetes Investigation.2020; 11(3): 564. CrossRef - The relationship between age of onset and risk factors including family history and life style in Korean population with type 2 diabetes mellitus
Jin-Won Noh, Jin Hee Jung, Jeong Eun Park, Jung Hwa Lee, Kang Hee Sim, Jumin Park, Min Hee Kim, Ki-Bong Yoo Journal of Physical Therapy Science.2018; 30(2): 201. CrossRef - Clinical Characteristics of Subjects with Sulfonylurea-Dependent Type 2 Diabetes
Se Hee Min, Soo Heon Kwak, Young Min Cho, Kyong Soo Park, Hye Seung Jung Endocrinology and Metabolism.2015; 30(4): 509. CrossRef - Nutritional Assessment of Type II Diabetic Patients
El-Sayed H. Bakr Pakistan Journal of Nutrition.2015; 14(6): 308. CrossRef
|