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Domenico Greco  (Greco D) 1 Article
Selective Immunoglobulin A Deficiency in Type 1 Diabetes Mellitus: A Prevalence Study in Western Sicily (Italy)
Domenico Greco, Filippo Maggio
Diabetes Metab J. 2015;39(2):132-136.   Published online March 10, 2015
DOI: https://doi.org/10.4093/dmj.2015.39.2.132
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  • 7 Web of Science
  • 8 Crossref
AbstractAbstract PDFPubReader   
Background

The association between type 1 diabetes and immunoglobulin A deficiency (IgA-D) has long been recognized in many populations. The aim of this study was to assess the prevalence of IgA-D in patients with type 1 diabetes mellitus all coming from a defined geographical area and to investigate the clinical features of these subjects.

Methods

The records of 150 consecutive patients with type 1 diabetes mellitus referred in a period of one year were analyzed. A detailed history was obtained for each patient. Information was collected concerning age, gender, time of onset of diabetes, and presence of other autoimmune diseases.

Results

Out of 150 patients with type 1 diabetes, eight (5.3%) had a diagnosis of IgA-D. There were one female and seven male; all these patients were diagnosed by screening: none of them had history of recurrent infections. Autoimmune thyroiditis was coexisting in five patients (62%). Although other associated autoimmune disorders were found in a number of patients, there was no different prevalence rate in IgA deficient patients.

Conclusion

This study shows the prevalence of IgA-D in Sicilian patients with type 1 diabetes as 5.3% which is much higher than reported in other Italian studies. Moreover, our data show a high prevalence of IgA-D in male gender and describe thyroiditis as the most frequent autoimmune disease present in these patients. Finally, in our case report, IgA-D diagnosis always followed routine IgA measurement when case finding for celiac disease with no history of recurrent infections in each patient.

Citations

Citations to this article as recorded by  
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    Journal of Diabetes and its Complications.2024; 38(1): 108667.     CrossRef
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    Sana Rafaqat, Aqsa Sattar, Amber Khalid, Saira Rafaqat
    Endocrine Regulations.2023; 57(1): 200.     CrossRef
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    PLOS ONE.2022; 17(11): e0277273.     CrossRef
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    Nigerian Journal of Medicine.2021; 30(6): 665.     CrossRef
  • Late-Onset T1DM and Older Age Predict Risk of Additional Autoimmune Disease
    Jing W. Hughes, Yicheng K. Bao, Maamoun Salam, Prajesh Joshi, C. Rachel Kilpatrick, Kavita Juneja, David Nieves, Victoria Bouhairie, Olivia J. Jordan, Erica C. Blustein, Garry S. Tobin, Janet B. McGill
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    Clinical Immunology.2017; 183: 336.     CrossRef

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