Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal


Author index

Page Path
HOME > Browse > Author index
Dawn Chung  (Chung D) 1 Article
Obesity and Metabolic Syndrome
Relationship between Regional Body Fat Distribution and Diabetes Mellitus: 2008 to 2010 Korean National Health and Nutrition Examination Surveys
Soo In Choi, Dawn Chung, Jung Soo Lim, Mi Young Lee, Jang Yel Shin, Choon Hee Chung, Ji Hye Huh
Diabetes Metab J. 2017;41(1):51-59.   Published online December 21, 2016
  • 4,492 View
  • 42 Download
  • 35 Web of Science
  • 36 Crossref
AbstractAbstract PDFPubReader   

The aim of this study was to investigate the association between regional body fat distribution, especially leg fat mass, and the prevalence of diabetes mellitus (DM) in adult populations.


A total of 3,181 men and 3,827 postmenopausal women aged 50 years or older were analyzed based on Korea National Health and Nutrition Examination Surveys (2008 to 2010). Body compositions including muscle mass and regional fat mass were measured using dual-energy X-ray absorptiometry.


The odds ratios (ORs) for DM was higher with increasing truncal fat mass and arm fat mass, while it was lower with increasing leg fat mass. In a partial correlation analysis adjusted for age, leg fat mass was negatively associated with glycosylated hemoglobin in both sexes and fasting glucose in women. Leg fat mass was positively correlated with appendicular skeletal muscle mass and homeostasis model assessment of β cell. In addition, after adjusting for confounding factors, the OR for DM decreased gradually with increasing leg fat mass quartiles in both genders. When we subdivided the participants into four groups based on the median values of leg fat mass and leg muscle mass, higher leg fat mass significantly lowered the risk of DM even though they have smaller leg muscle mass in both genders (P<0.001).


The relationship between fat mass and the prevalence of DM is different according to regional body fat distribution. Higher leg fat mass was associated with a lower risk of DM in Korean populations. Maintaining leg fat mass may be important in preventing impaired glucose tolerance.


Citations to this article as recorded by  
  • Effects of chromium supplementation on body composition in patients with type 2 diabetes: A dose-response systematic review and meta-analysis of randomized controlled trials
    Mahdi Vajdi, Mahsa khajeh, Ehsan Safaei, Seyedehelham Moeinolsadat, Samin Mousavi, Hooria Seyedhosseini-Ghaheh, Mahdieh Abbasalizad-Farhangi, Gholamreza Askari
    Journal of Trace Elements in Medicine and Biology.2024; 81: 127338.     CrossRef
  • Connections between body composition and dysregulation of islet α- and β-cells in type 2 diabetes
    Jia-xi Miao, Jia-ping Xu, Rui Wang, Yu-xian Xu, Feng Xu, Chun-hua Wang, Chao Yu, Dong-mei Zhang, Jian-bin Su
    Diabetology & Metabolic Syndrome.2024;[Epub]     CrossRef
  • Anthropometric and DXA-derived measures of body composition in relation to pre-diabetes among adults
    Anwar Mohammad, Ali H. Ziyab, Talal Mohammad
    BMJ Open Diabetes Research & Care.2023; 11(5): e003412.     CrossRef
  • A cohort study on the predictive capability of body composition for diabetes mellitus using machine learning
    Mohammad Ali Nematollahi, Amir Askarinejad, Arefeh Asadollahi, Mehdi Bazrafshan, Shirin Sarejloo, Mana Moghadami, Sarvin Sasannia, Mojtaba Farjam, Reza Homayounfar, Babak Pezeshki, Mitra Amini, Mohamad Roshanzamir, Roohallah Alizadehsani, Hanieh Bazrafsha
    Journal of Diabetes & Metabolic Disorders.2023; 23(1): 773.     CrossRef
  • Which is the best diet to reduce cardiometabolic risk: dietary counseling or home-delivered diet?
    Feray Çağiran Yilmaz, Aysun Atilgan, Günay Saka
    Food & Nutrition Research.2023;[Epub]     CrossRef
  • Sedentary lifestyle and body composition in type 2 diabetes
    Dan-dan Li, Yang Yang, Zi-yi Gao, Li-hua Zhao, Xue Yang, Feng Xu, Chao Yu, Xiu-lin Zhang, Xue-qin Wang, Li-hua Wang, Jian-bin Su
    Diabetology & Metabolic Syndrome.2022;[Epub]     CrossRef
  • Impaired Lung Function and Lung Cancer Incidence: A Nationwide Population-Based Cohort Study
    Hye Seon Kang, Yong-Moon Park, Seung-Hyun Ko, Seung Hoon Kim, Shin Young Kim, Chi Hong Kim, Kyungdo Han, Sung Kyoung Kim
    Journal of Clinical Medicine.2022; 11(4): 1077.     CrossRef
  • Association between lung function and the risk of atrial fibrillation in a nationwide population cohort study
    Su Nam Lee, Seung-Hyun Ko, Sung-Ho Her, Kyungdo Han, Donggyu Moon, Sung Kyoung Kim, Ki-Dong Yoo, Yu-Bae Ahn
    Scientific Reports.2022;[Epub]     CrossRef
  • Is imaging-based muscle quantity associated with risk of diabetes? A meta-analysis of cohort studies
    Shanhu Qiu, Xue Cai, Yang Yuan, Bo Xie, Zilin Sun, Tongzhi Wu
    Diabetes Research and Clinical Practice.2022; 189: 109939.     CrossRef
  • Research Progress of Body Composition Changes in Type 2 Diabetes Patients
    鹏霞 张
    Advances in Clinical Medicine.2022; 12(08): 7181.     CrossRef
  • Associations of eating speed with fat distribution and body shape vary in different age groups and obesity status
    Saili Ni, Menghan Jia, Xuemiao Wang, Yun Hong, Xueyin Zhao, Liang Zhang, Yuan Ru, Fei Yang, Shankuan Zhu
    Nutrition & Metabolism.2022;[Epub]     CrossRef
  • Body composition, trabecular bone score and vertebral fractures in subjects with Klinefelter syndrome
    W. Vena, F. Carrone, A. Delbarba, O. Akpojiyovbi, L. C. Pezzaioli, P. Facondo, C. Cappelli, L. Leonardi, L. Balzarini, D. Farina, A. Pizzocaro, A. G. Lania, G. Mazziotti, A. Ferlin
    Journal of Endocrinological Investigation.2022; 46(2): 297.     CrossRef
  • Genetically predicted body fat mass and distribution with diabetic kidney disease: A two-sample Mendelian randomization study
    Min Wang, Xin Li, Hang Mei, Zhao-Hui Huang, Yue Liu, Yong-Hong Zhu, Tian-Kui Ma, Qiu-Ling Fan
    Frontiers in Genetics.2022;[Epub]     CrossRef
  • Screening for Prediabetes and Diabetes in Korean Nonpregnant Adults: A Position Statement of the Korean Diabetes Association, 2022
    Kyung Ae Lee, Dae Jung Kim, Kyungdo Han, Suk Chon, Min Kyong Moon
    Diabetes & Metabolism Journal.2022; 46(6): 819.     CrossRef
  • Age- and Sex-Related Differential Associations between Body Composition and Diabetes Mellitus
    Eun Roh, Soon Young Hwang, Jung A Kim, You-Bin Lee, So-hyeon Hong, Nam Hoon Kim, Ji A Seo, Sin Gon Kim, Nan Hee Kim, Kyung Mook Choi, Sei Hyun Baik, Hye Jin Yoo
    Diabetes & Metabolism Journal.2021; 45(2): 183.     CrossRef
  • Neck circumference and metabolic syndrome: A cross-sectional population-based study
    Hooman Ebrahimi, Payam Mahmoudi, Farhad Zamani, Sedighe Moradi
    Primary Care Diabetes.2021; 15(3): 582.     CrossRef
  • Development of a clinical risk score for incident diabetes: A 10‐year prospective cohort study
    Tae Jung Oh, Jae Hoon Moon, Sung Hee Choi, Young Min Cho, Kyong Soo Park, Nam H Cho, Hak Chul Jang
    Journal of Diabetes Investigation.2021; 12(4): 610.     CrossRef
  • The association of glucocorticoid receptor polymorphism with metabolic outcomes in menopausal women with adrenal incidentalomas
    Sanja Ognjanović, Jadranka Antić, Tatjana Pekmezović, Bojana Popović, Tatjana Isailović, Ivana Božić Antić, Tamara Bogavac, Valentina Elezović Kovačević, Dušan Ilić, Milica Opalić, Djuro Macut
    Maturitas.2021; 151: 15.     CrossRef
  • Distinct opposing associations of upper and lower body fat depots with metabolic and cardiovascular disease risk markers
    Mahasampath Gowri S, Belavendra Antonisamy, Finney S. Geethanjali, Nihal Thomas, Felix Jebasingh, Thomas V. Paul, Fredrik Karpe, Clive Osmond, Caroline H. D. Fall, Senthil K. Vasan
    International Journal of Obesity.2021; 45(11): 2490.     CrossRef
  • Body Roundness Index Is a Superior Obesity Index in Predicting Diabetes Risk Among Hypertensive Patients: A Prospective Cohort Study in China
    Yingshan Liu, Xiaocong Liu, Haixia Guan, Shuting Zhang, Qibo Zhu, Xiaoying Fu, Hongmei Chen, Songtao Tang, Yingqing Feng, Jian Kuang
    Frontiers in Cardiovascular Medicine.2021;[Epub]     CrossRef
  • Subcutaneous adipose tissue distribution and serum lipid/lipoprotein in unmedicated postmenopausal women: A B-mode ultrasound study

    Imaging.2021; 13(2): 119.     CrossRef
  • The Leg Fat to Total Fat Ratio Is Associated with Lower Risks of Non-Alcoholic Fatty Liver Disease and Less Severe Hepatic Fibrosis: Results from Nationwide Surveys (KNHANES 2008–2011)
    Hyun Min Kim, Yong-ho Lee
    Endocrinology and Metabolism.2021; 36(6): 1232.     CrossRef
  • Optimal Cut-Offs of Body Mass Index and Waist Circumference to Identify Obesity in Chinese Type 2 Diabetic Patients

    Qinying Zhao, Xiangjun Chen, Jinshan Wu, Lilin Gong, Jinbo Hu, Shumin Yang, Qifu Li, Zhihong Wang
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2020; Volume 13: 1899.     CrossRef
  • Weight Loss after 12 Weeks of Exercise and/or Nutritional Guidance Is Not Obligatory for Induced Changes in Local Fat/Lean Mass Indexes in Adults with Excess of Adiposity
    Robinson Ramírez-Vélez, Mikel Izquierdo, Karem Castro-Astudillo, Carolina Medrano-Mena, Angela Liliana Monroy-Díaz, Rocío del Pilar Castellanos-Vega, Héctor Reynaldo Triana-Reina, María Correa-Rodríguez
    Nutrients.2020; 12(8): 2231.     CrossRef
    Laércio Camilo Rodrigues, Marcos de Sá Rego Fortes, Marco Antônio Muniz Lippert, Samir Ezequiel Da Rosa, José Fernandes Filho
    Revista Brasileira de Medicina do Esporte.2020; 26(1): 21.     CrossRef
  • Comparison of 7-site skinfold measurement and dual-energy X-ray absorptiometry for estimating body fat percentage and regional adiposity in Taiwanese diabetic patients
    Feng-Chih Kuo, Chieh-Hua Lu, Li-Wei Wu, Tung-Wei Kao, Sheng-Chiang Su, Jhih-Syuan Liu, Kuan-Chan Chen, Chia-Hao Chang, Chih-Chun Kuo, Chien-Hsing Lee, Chang-Hsun Hsieh, Mauro Lombardo
    PLOS ONE.2020; 15(7): e0236323.     CrossRef
  • Outcomes specific to patient sex after open ventral hernia repair
    Kathryn A. Schlosser, Sean R. Maloney, Otto Thielan, Tanushree Prasad, Kent Kercher, Paul D. Colavita, B Todd Heniford, Vedra A. Augenstein
    Surgery.2020; 167(3): 614.     CrossRef
  • Age-Related Changes in Body Composition and Bone Mineral Density and Their Relationship with the Duration of Diabetes and Glycaemic Control in Type 2 Diabetes

    Ying Tang, Lilin Gong, Xiangjun Chen, Zhipeng Du, Jinbo Hu, Zhixin Xu, Jinshan Wu, Qifu Li, Zhihong Wang
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2020; Volume 13: 4699.     CrossRef
  • Lipodystrophy: A paradigm for understanding the consequences of "overloading" adipose tissue
    Koini Lim, Afreen Haider, Claire Adams, Alison Sleigh, David Savage
    Physiological Reviews.2020;[Epub]     CrossRef
  • Premeal Consumption of a Protein-Enriched, Dietary Fiber-Fortified Bar Decreases Total Energy Intake in Healthy Individuals
    Chang Ho Ahn, Jae Hyun Bae, Young Min Cho
    Diabetes & Metabolism Journal.2019; 43(6): 879.     CrossRef
  • Differences in dietary intakes, body compositions, and biochemical indices between metabolically healthy and metabolically abnormal obese Korean women
    Eun Yeong Kang, Jung-Eun Yim
    Nutrition Research and Practice.2019; 13(6): 488.     CrossRef
  • The Association between Body Composition using Dual energy X-ray Absorptiometry and Type-2 Diabetes: A Systematic Review and Meta-Analysis of Observational studies
    Preeti Gupta, Carla Lanca, Alfred T. L. Gan, Pauline Soh, Sahil Thakur, Yijin Tao, Neelam Kumari, Ryan E. K. Man, Eva K. Fenwick, Ecosse L. Lamoureux
    Scientific Reports.2019;[Epub]     CrossRef
  • Genes that make you fat, but keep you healthy
    R. J. F. Loos, T. O. Kilpeläinen
    Journal of Internal Medicine.2018; 284(5): 450.     CrossRef
  • Overview of Epidemiology and Contribution of Obesity and Body Fat Distribution to Cardiovascular Disease: An Update
    Marie-Eve Piché, Paul Poirier, Isabelle Lemieux, Jean-Pierre Després
    Progress in Cardiovascular Diseases.2018; 61(2): 103.     CrossRef
  • Relevance of human fat distribution on lipid and lipoprotein metabolism and cardiovascular disease risk
    Marie-Eve Piché, Senthil K. Vasan, Leanne Hodson, Fredrik Karpe
    Current Opinion in Lipidology.2018; 29(4): 285.     CrossRef
  • Comparison of regional fat measurements by dual-energy X-ray absorptiometry and conventional anthropometry and their association with markers of diabetes and cardiovascular disease risk
    S K Vasan, C Osmond, D Canoy, C Christodoulides, M J Neville, C Di Gravio, C H D Fall, F Karpe
    International Journal of Obesity.2018; 42(4): 850.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal
Close layer