- Complications
- Autophagy: A Novel Therapeutic Target for Diabetic Nephropathy
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Shinji Kume, Daisuke Koya
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Diabetes Metab J. 2015;39(6):451-460. Published online December 11, 2015
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DOI: https://doi.org/10.4093/dmj.2015.39.6.451
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Diabetic nephropathy is a leading cause of end stage renal disease and its occurance is increasing worldwide. The most effective treatment strategy for the condition is intensive treatment to strictly control glycemia and blood pressure using renin-angiotensin system inhibitors. However, a fraction of patients still go on to reach end stage renal disease even under such intensive care. New therapeutic targets for diabetic nephropathy are, therefore, urgently needed. Autophagy is a major catabolic pathway by which mammalian cells degrade macromolecules and organelles to maintain intracellular homeostasis. The accumulation of damaged proteins and organelles is associated with the pathogenesis of diabetic nephropathy. Autophagy in the kidney is activated under some stress conditions, such as oxidative stress and hypoxia in proximal tubular cells, and occurs even under normal conditions in podocytes. These and other accumulating findings have led to a hypothesis that autophagy is involved in the pathogenesis of diabetic nephropathy. Here, we review recent findings underpinning this hypothesis and discuss the advantages of targeting autophagy for the treatment of diabetic nephropathy.
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- SIRT1 in Type 2 Diabetes: Mechanisms and Therapeutic Potential
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Munehiro Kitada, Daisuke Koya
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Diabetes Metab J. 2013;37(5):315-325. Published online October 17, 2013
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DOI: https://doi.org/10.4093/dmj.2013.37.5.315
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7,614
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The prevalence of type 2 diabetes mellitus (T2DM) has been increasing worldwide. Therefore, a novel therapeutic strategy by which to prevent T2DM is urgently required. Calorie restriction (CR) can retard the aging processes, and delay the onset of numerous age-related diseases including diabetes. Metabolic CR mimetics may be therefore included as novel therapeutic targets for T2DM. Sirtuin 1 (SIRT1), a NAD+-dependent histone deacetylase that is induced by CR, is closely associated with lifespan elongation under CR. SIRT1 regulates glucose/lipid metabolism through its deacetylase activity on many substrates. SIRT1 in pancreatic β-cells positively regulates insulin secretion and protects cells from oxidative stress and inflammation, and has positive roles in the metabolic pathway via the modulation in insulin signaling. SIRT1 also regulates adiponectin secretion, inflammation, glucose production, oxidative stress, mitochondrial function, and circadian rhythms. Several SIRT1 activators, including resveratrol have been demonstrated to have beneficial effects on glucose homeostasis and insulin sensitivity in animal models of insulin resistance. Therefore, SIRT1 may be a novel therapeutic target for the prevention of T2DM, implicating with CR. In this review, we summarize current understanding of the biological functions of SIRT1 and discuss its potential as a promising therapeutic target for T2DM.
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Shima Abdollahi, Amin Salehi‐Abargouei, Omid Toupchian, Mohammad Hasan Sheikhha, Hossein Fallahzadeh, Masoud Rahmanian, Mahtab Tabatabaie, Hassan Mozaffari‐Khosravi Phytotherapy Research.2019; 33(12): 3153. CrossRef - Sirtuins and diabetes: optimizing the sweetness in the blood
Abhinav Kanwal, Liston Augustine Dsouza Translational Medicine Communications.2019;[Epub] CrossRef - In silico and in vitro identification of candidate SIRT1 activators from Indonesian medicinal plants compounds database
Azminah Azminah, Linda Erlina, Maksum Radji, Abdul Mun’im, Rezi Riadhi Syahdi, Arry Yanuar Computational Biology and Chemistry.2019; 83: 107096. CrossRef - Ginsenoside Rb1 Attenuates High Glucose-Induced Oxidative Injury via the NAD-PARP-SIRT Axis in Rat Retinal Capillary Endothelial Cells
Chunlan Fan, Qing Ma, Meng Xu, Yuan Qiao, Yi Zhang, Pin Li, Yucong Bi, Minke Tang International Journal of Molecular Sciences.2019; 20(19): 4936. CrossRef - Effects and Underlying Mechanisms of Bioactive Compounds on Type 2 Diabetes Mellitus and Alzheimer’s Disease
Rongzi Li, Yuxian Zhang, Suhail Rasool, Thangiah Geetha, Jeganathan Ramesh Babu Oxidative Medicine and Cellular Longevity.2019; 2019: 1. CrossRef - Selection of reference genes for miRNA quantitative PCR and its application in miR-34a/Sirtuin-1 mediated energy metabolism in Megalobrama amblycephala
Jie Liu, Erteng Jia, Huajuan Shi, Xiangfei Li, Guangzhen Jiang, Cheng Chi, Wenbin Liu, Dingdong Zhang Fish Physiology and Biochemistry.2019; 45(5): 1663. CrossRef - Fucoxanthin Alleviates Oxidative Stress through Akt/Sirt1/FoxO3α Signaling to Inhibit HG-Induced Renal Fibrosis in GMCs
Guanyu Yang, Lin Jin, Dongxiao Zheng, Xiaoliang Tang, Junwei Yang, Lingxuan Fan, Xi Xie Marine Drugs.2019; 17(12): 702. CrossRef - Melatonin attenuates acute kidney ischemia/reperfusion injury in diabetic rats by activation of the SIRT1/Nrf2/HO-1 signaling pathway
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Wanning Wang, Weixia Sun, Yanli Cheng, Zhonggao Xu, Lu Cai Journal of Molecular Medicine.2019; 97(3): 291. CrossRef - Sirtuins and Type 2 Diabetes: Role in Inflammation, Oxidative Stress, and Mitochondrial Function
Munehiro Kitada, Yoshio Ogura, Itaru Monno, Daisuke Koya Frontiers in Endocrinology.2019;[Epub] CrossRef - Mechanistic insights into the effect of lutein on atherosclerosis, vascular dysfunction, and related risk factors: A systematic review of in vivo, ex vivo and in vitro studies
Fatemeh Hajizadeh-Sharafabad, Zohreh Ghoreishi, Vahid Maleki, Ali Tarighat-Esfanjani Pharmacological Research.2019; 149: 104477. CrossRef - Chronic whole-body heat treatment relieves atherosclerotic lesions, cardiovascular and metabolic abnormalities, and enhances survival time restoring the anti-inflammatory and anti-senescent heat shock response in mice
Maciel Alencar Bruxel, Angela Maria Vicente Tavares, Luiz Domingues Zavarize Neto, Victor de Souza Borges, Helena Trevisan Schroeder, Patricia Martins Bock, Maria Inês Lavina Rodrigues, Adriane Belló-Klein, Paulo Ivo Homem de Bittencourt Biochimie.2019; 156: 33. CrossRef - Swimming training by affecting the pancreatic Sirtuin1 (SIRT1) and oxidative stress, improves insulin sensitivity in diabetic male rats
Rafighe Ghiasi, Roya Naderi, Roghayeh Sheervalilou, Mohammad Reza Alipour Hormone Molecular Biology and Clinical Investigation.2019;[Epub] CrossRef - Adipose-Derived Mesenchymal Stem Cells Isolated from Patients with Type 2 Diabetes Show Reduced “Stemness” through an Altered Secretome Profile, Impaired Anti-Oxidative Protection, and Mitochondrial Dynamics Deterioration
Michalina Alicka, Piotr Major, Michał Wysocki, Krzysztof Marycz Journal of Clinical Medicine.2019; 8(6): 765. CrossRef - A novel recombinant peptide INSR-IgG4Fc (Yiminsu) restores insulin sensitivity in experimental insulin resistance models
Jing Wang, Zhe Shi, Tao Zou, Min-Xu Zou, Hui-Xian Yang, Cai-Ping Zhang, De-Biao Xiang, Li-Mei Lin, Hui-Yu Liu, De-yu Fang, Duan-Fang Liao Biomedicine & Pharmacotherapy.2019; 109: 1276. CrossRef - Immunometabolism and Pulmonary Infections: Implications for Protective Immune Responses and Host-Directed Therapies
Martin Rao, Ernest Dodoo, Alimuddin Zumla, Markus Maeurer Frontiers in Microbiology.2019;[Epub] CrossRef - Salvianolic Acid B Attenuates Apoptosis of HUVEC Cells Treated with High Glucose or High Fat via Sirt1 Activation
Jinghui Zhai, Lina Tao, Yueming Zhang, Huan Gao, Xiaoyu Qu, Yanqing Song, Sixi Zhang Evidence-Based Complementary and Alternative Medicine.2019; 2019: 1. CrossRef - Obesity programmed by prenatal dexamethasone and postnatal high-fat diet leads to distinct alterations in nutrition sensory signals and circadian-clock genes in visceral adipose tissue
Ching-Chou Tsai, Mao-Meng Tiao, Jiunn-Ming Sheen, Li-Tung Huang, You-Lin Tain, I-Chun Lin, Yu-Ju Lin, Yun-Ju Lai, Chih-Cheng Chen, Kow-Aung Chang, Hong-Ren Yu Lipids in Health and Disease.2019;[Epub] CrossRef - Mapping Research in the Obesity, Adipose Tissue, and MicroRNA Field: A Bibliometric Analysis
João Manoel Alves, Ramon Handerson Gomes Teles, Camila do Valle Gomes Gatto, Vitor Rosetto Muñoz, Márcia Regina Cominetti, Ana Cláudia Garcia de Oliveira Duarte Cells.2019; 8(12): 1581. CrossRef - Chronic hypoglycemic effect and phytochemical composition of Smilax moranensis roots
Adriana Romo-Pérez, Sonia Marlen Escandón-Rivera, Adolfo Andrade-Cetto Revista Brasileira de Farmacognosia.2019; 29(2): 246. CrossRef - Prevention of kidney cell damage in hyperglycaemia condition by adiponectin
Sajad Esmaeili, Maryam Motamedrad, Mina Hemmati, Omid Mehrpour, Mohsen Khorashadizadeh Cell Biochemistry and Function.2019; 37(3): 148. CrossRef - Molecular Mechanism of the Protective Effect of Zerumbone on Lipopolysaccharide-Induced Inflammation of THP-1 Cell-Derived Macrophages
Min-Ju Kim, Jung-Mi Yun Journal of Medicinal Food.2019; 22(1): 62. CrossRef - Impairment of PPARα and the Fatty Acid Oxidation Pathway Aggravates Renal Fibrosis during Aging
Ki Wung Chung, Eun Kyeong Lee, Mi Kyung Lee, Goo Taeg Oh, Byung Pal Yu, Hae Young Chung Journal of the American Society of Nephrology.2018; 29(4): 1223. CrossRef - Pomegranate Juice Increases Sirtuin1 Protein in Peripheral Blood Mononuclear Cell from Patients with Type 2 Diabetes: A Randomized Placebo Controlled Clinical Trial
Golbon Sohrab, Javad Nasrollahzadeh, Maryam Tohidi, Hamid Zand, Omid Nikpayam Metabolic Syndrome and Related Disorders.2018; 16(8): 446. CrossRef - Effect of resveratrol treatment on graft revascularization after islet transplantation in streptozotocin-induced diabetic mice
Eun-Mi Lee, Inwon Park, Ye-Jee Lee, Young-Hye You, Ji-Won Kim, Myung-Jun Kim, Yu-Bae Ahn, Pilhan Kim, Seung-Hyun Ko Islets.2018; 10(1): 25. CrossRef - miR‐221 negatively regulates inflammation and insulin sensitivity in white adipose tissue by repression of sirtuin‐1 (SIRT1)
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Robin Bonomi, Vadim Popov, Maxwell T. Laws, David Gelovani, Anjoy Majhi, Aleksandr Shavrin, Xin Lu, Otto Muzik, Nashaat Turkman, Renshyan Liu, Thomas Mangner, Juri G. Gelovani Journal of Medicinal Chemistry.2018; 61(16): 7116. CrossRef -
Vitamin B
12
Supplementation Influences Methylation of Genes Associated with Type 2 Diabetes and Its Intermediate Traits
Dilip K Yadav, Smeeta Shrestha, Karen A Lillycrop, Charu V Joglekar, Hong Pan, Joanna D Holbrook, Caroline HD Fall, Chittaranjan S Yajnik, Giriraj R Chandak Epigenomics.2018; 10(1): 71. CrossRef - The effects of green cardamom supplementation on blood glucose, lipids profile, oxidative stress, sirtuin-1 and irisin in type 2 diabetic patients: a study protocol for a randomized placebo-controlled clinical trial
Mohadeseh Aghasi, Shohreh Ghazi-Zahedi, Fariba Koohdani, Fereydoun Siassi, Ensieh Nasli-Esfahani, Ali Keshavarz, Mostafa Qorbani, Hoorieh Khoshamal, Asma Salari-Moghaddam, Gity Sotoudeh BMC Complementary and Alternative Medicine.2018;[Epub] CrossRef - LincRNA 1700020I14Rik alleviates cell proliferation and fibrosis in diabetic nephropathy via miR-34a-5p/Sirt1/HIF-1α signaling
Ailing Li, Rui Peng, Yan Sun, Handeng Liu, Huimin Peng, Zheng Zhang Cell Death & Disease.2018;[Epub] CrossRef - Treatment of NASH with Antioxidant Therapy: Beneficial Effect of Red Cabbage on Type 2 Diabetic Rats
Stéphanie Dal, Remmelt Van der Werf, Catherine Walter, William Bietiger, Elodie Seyfritz, Carole Mura, Claude Peronet, Julie Legrandois, Dalal Werner, Said Ennahar, Fabien Digel, Maillard-Pedracini Elisa, Michel Pinget, Nathalie Jeandidier, Eric Marchioni Oxidative Medicine and Cellular Longevity.2018;[Epub] CrossRef - Formononetin Treatment in Type 2 Diabetic Rats Reduces Insulin Resistance and Hyperglycemia
Manisha J. Oza, Yogesh A. Kulkarni Frontiers in Pharmacology.2018;[Epub] CrossRef - Tocotrienol-rich fraction supplementation reduces hyperglycemia-induced skeletal muscle damage through regulation of insulin signaling and oxidative stress in type 2 diabetic mice
Heaji Lee, Yunsook Lim The Journal of Nutritional Biochemistry.2018; 57: 77. CrossRef - Circulating soluble RAGE isoforms are attenuated in obese, impaired-glucose-tolerant individuals and are associated with the development of type 2 diabetes
Edwin R. Miranda, Vikram S. Somal, Jacob T. Mey, Brian K. Blackburn, Edward Wang, Sarah Farabi, Kristian Karstoft, Ciaran E. Fealy, Sangeeta Kashyap, John P. Kirwan, Laurie Quinn, Thomas P. J. Solomon, Jacob M. Haus American Journal of Physiology-Endocrinology and Metabolism.2017; 313(6): E631. CrossRef - Combination Treatments with Luteolin and Fisetin Enhance Anti-Inflammatory Effects in High Glucose-Treated THP-1 Cells Through Histone Acetyltransferase/Histone Deacetylase Regulation
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Rüdiger Hardeland Journal of Pineal Research.2017;[Epub] CrossRef - HSF1 acetylation decreases its transcriptional activity and enhances glucolipotoxicity-induced apoptosis in rat and human beta cells
Indri Purwana, Jun J. Liu, Bernard Portha, Jean Buteau Diabetologia.2017; 60(8): 1432. CrossRef - Tangshen formula improves inflammation in renal tissue of diabetic nephropathy through SIRT1/NF-κB pathway
Yue‑Guang Du, Ke‑Na Zhang, Zong‑Lei Gao, Fengjiao Dai, Xi‑Xi Wu, Ke‑Fu Chai Experimental and Therapeutic Medicine.2017;[Epub] CrossRef - MiR-377 promotes white adipose tissue inflammation and decreases insulin sensitivity in obesity via suppression of sirtuin-1 (SIRT1)
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Hedyieh Karbasforooshan, Gholamreza Karimi Biomedicine & Pharmacotherapy.2017; 90: 386. CrossRef - Long-term obestatin treatment of mice type 2 diabetes increases insulin sensitivity and improves liver function
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Tingting Hu, Ye Chen, Qian Jiang, Jun Lin, Hewei Li, Ping Wang, Leping Feng Experimental and Therapeutic Medicine.2017; 14(2): 1727. CrossRef - Resveratrol attenuates type 2 diabetes mellitus by mediating mitochondrial biogenesis and lipid metabolism via Sirtuin type 1
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Caio Yonamine, Erika Pinheiro-Machado, Maria Michalani, Ana Alves-Wagner, João Esteves, Helayne Freitas, Ubiratan Machado Molecules.2017; 22(7): 1180. CrossRef - Sleep restriction induced energy, methylation and lipogenesis metabolic switches in rat liver
Arjun Sengupta, Seth D. Rhoades, Eun Ji Kim, Soumyashant Nayak, Gregory R. Grant, Peter Meerlo, Aalim M. Weljie The International Journal of Biochemistry & Cell Biology.2017; 93: 129. CrossRef - Natural mineral-rich water ingestion by ovariectomized fructose-fed Sprague-Dawley rats: effects on sirtuin 1 and glucocorticoid signaling pathways
Jugal Kishore Das, Milton Severo, Cidália Dionísio Pereira, Emília Patrício, José Magalhães, Rosário Monteiro, Delminda Neves, Maria João Martins Menopause.2017; 24(5): 563. CrossRef - SIRT1 attenuates neuropathic pain by epigenetic regulation of mGluR1/5 expressions in type 2 diabetic rats
Cheng-Hua Zhou, Ming-Xing Zhang, Sha-Sha Zhou, Huan Li, Jian Gao, Lei Du, Xiao-Xing Yin Pain.2017; 158(1): 130. CrossRef - MiR-34a contributes to diabetes-related cochlear hair cell apoptosis via SIRT1/HIF-1α signaling
Ying Lin, Jinjin Shen, Danfeng Li, Jie Ming, Xiangyang Liu, Nana Zhang, Jingbo Lai, Min Shi, Qiuhe Ji, Ying Xing General and Comparative Endocrinology.2017; 246: 63. CrossRef - High glucose upregulates endothelin type B receptors in vascular smooth muscle cells via the downregulation of Sirt1
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Nal Ae Yoon, Juyeong Park, Jiyeon Lee, Joo Yeon Jeong, Hyun-Kyu Kim, Hak Sung Lee, In Guk Hwang, Gu Seob Roh, Hyun Joon Kim, Gyeong Jae Cho, Wan Sung Choi, Dong Hoon Lee, Sang Soo Kang Development & Reproduction.2017; 21(3): 259. CrossRef - Thymoquinone ameliorates diabetic phenotype in Diet-Induced Obesity mice via activation of SIRT-1-dependent pathways
Shpetim Karandrea, Huquan Yin, Xiaomei Liang, Angela L. Slitt, Emma A. Heart, Guillermo López Lluch PLOS ONE.2017; 12(9): e0185374. CrossRef - Artesunate protects pancreatic beta cells against cytokine-induced damage via SIRT1 inhibiting NF-κB activation
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C.S. Harrell, C.F. Gillespie, G.N. Neigh Physiology & Behavior.2016; 166: 43. CrossRef - Ligand-based virtual screening and inductive learning for identification of SIRT1 inhibitors in natural products
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Si-Young Cho, Juewon Kim, Ji Hae Lee, Ji Hyun Sim, Dong-Hyun Cho, Il-Hong Bae, Hyunbok Lee, Min A. Seol, Hyun Mu Shin, Tae-Joo Kim, Dae-Yong Kim, Su-Hyung Lee, Song Seok Shin, Sin-Hyeog Im, Hang-Rae Kim Scientific Reports.2016;[Epub] CrossRef - Frailty and sarcopenia as the basis for the phenotypic manifestation of chronic diseases in older adults
Javier Angulo, Mariam El Assar, Leocadio Rodríguez-Mañas Molecular Aspects of Medicine.2016; 50: 1. CrossRef - Sirt1 is essential for resveratrol enhancement of hypoxia-induced autophagy in the type 2 diabetic nephropathy rat
Liqun Ma, Rongguo Fu, Zhaoyang Duan, Jiamei Lu, Jie Gao, Lifang Tian, Zhian Lv, Zhao Chen, Jin Han, Lining Jia, Li Wang Pathology - Research and Practice.2016; 212(4): 310. CrossRef - The Ticking of the Epigenetic Clock: Antipsychotic Drugs in Old Age
Adonis Sfera, Carolina Osorio, Luzmin Inderias, Michael Cummings Frontiers in Endocrinology.2016;[Epub] CrossRef - ZLN005 protects cardiomyocytes against high glucose-induced cytotoxicity by promoting SIRT1 expression and autophagy
Wenju Li, Xiaoli Li, Bin Wang, Yan Chen, Aiping Xiao, Di Zeng, Dongbo Ou, Song Yan, Wei Li, Qiangsun Zheng Experimental Cell Research.2016; 345(1): 25. CrossRef - How much successful are the medicinal chemists in modulation of SIRT1: A critical review
Ashwani Kumar, Shilpi Chauhan European Journal of Medicinal Chemistry.2016; 119: 45. CrossRef - Network Based Approach in the Establishment of the Relationship between Type 2 Diabetes Mellitus and Its Complications at the Molecular Level Coupled with Molecular Docking Mechanism
Shailima Rampogu, Mary Rampogu Lemuel BioMed Research International.2016; 2016: 1. CrossRef - 1,4-Dihydropyridines Active on the SIRT1/AMPK Pathway Ameliorate Skin Repair and Mitochondrial Function and Exhibit Inhibition of Proliferation in Cancer Cells
Sergio Valente, Paolo Mellini, Francesco Spallotta, Vincenzo Carafa, Angela Nebbioso, Lucia Polletta, Ilaria Carnevale, Serena Saladini, Daniela Trisciuoglio, Chiara Gabellini, Maria Tardugno, Clemens Zwergel, Chiara Cencioni, Sandra Atlante, Sébastien Mo Journal of Medicinal Chemistry.2016; 59(4): 1471. CrossRef - Antidiabetic Effects of Resveratrol: The Way Forward in Its Clinical Utility
Omolola R. Oyenihi, Ayodeji B. Oyenihi, Anne A. Adeyanju, Oluwafemi O. Oguntibeju Journal of Diabetes Research.2016; 2016: 1. CrossRef - Mechanism of uncoupling protein 2-mediated myocardial injury in hypothermic preserved rat hearts
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Xiao‐Zhi Bai, Jia‐Qi Liu, Long‐Long Yang, Lei Fan, Ting He, Lin‐Lin Su, Ji‐Hong Shi, Chao‐Wu Tang, Zhao Zheng, Da‐Hai Hu British Journal of Pharmacology.2016; 173(10): 1589. CrossRef - Physiological regulation of the heat shock response by glutamine: implications for chronic low-grade inflammatory diseases in age-related conditions
Jaqueline Santos Moreira Leite, Vinicius Fernandes Cruzat, Mauricio Krause, Paulo Ivo Homem de Bittencourt Nutrire.2016;[Epub] CrossRef - In Patients with Coronary Artery Disease and Type 2 Diabetes, SIRT1 Expression in Circulating Mononuclear Cells Is Associated with Levels of Inflammatory Cytokines but Not with Coronary Lesions
Yuanmin Li, Jing Ni, Rong Guo, Weiming Li BioMed Research International.2016; 2016: 1. CrossRef - The role of bile acids in metabolic regulation
Libor Vítek, Martin Haluzík Journal of Endocrinology.2016; 228(3): R85. CrossRef - New Perspectives on the Development of Antiobesity Drugs
Luca Costantino, Daniela Barlocco Future Medicinal Chemistry.2015; 7(3): 315. CrossRef - SIRT1 protects against myocardial ischemia–reperfusion injury via activating eNOS in diabetic rats
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Tomasz Szkudelski, Katarzyna Szkudelska Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2015; 1852(6): 1145. CrossRef - Resveratrol restores the circadian rhythmic disorder of lipid metabolism induced by high-fat diet in mice
Linjie Sun, Yan Wang, Yu Song, Xiang-Rong Cheng, Shufang Xia, Md Ramim Tanver Rahman, Yonghui Shi, Guowei Le Biochemical and Biophysical Research Communications.2015; 458(1): 86. CrossRef - DPP‐4 Inhibitor Linagliptin Attenuates Aβ‐induced Cytotoxicity through Activation of AMPK in Neuronal Cells
Edy Kornelius, Chih‐Li Lin, Hsiu‐Han Chang, Hsin‐Hua Li, Wen‐Nung Huang, Yi‐Sun Yang, Ying‐Li Lu, Chiung‐Huei Peng, Chien‐Ning Huang CNS Neuroscience & Therapeutics.2015; 21(7): 549. CrossRef - Effects of Caloric Intake on Learning and Memory Function in Juvenile C57BL/6J Mice
Bao-Lei Xu, Rong Wang, Li-Na Ma, Wen Dong, Zhi-Wei Zhao, Jing-Shuang Zhang, Yu-Lan Wang, Xu Zhang BioMed Research International.2015; 2015: 1. CrossRef - Inhibition of microRNA-9-3p reduces lipid accumulation in HepG2 cells by targeting the expression of sirtuin type 1
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FEI LIU, QIANQIAN SUN, LINGXIAO WANG, SHUANGSHUANG NIE, JUN LI Molecular Medicine Reports.2015; 12(1): 351. CrossRef - Resveratrol Protects against Methylglyoxal-Induced Hyperglycemia and Pancreatic Damage In Vivo
An-Sheng Cheng, Yu-Hsiang Cheng, Chi-Ying Lee, Chin-Yuan Chung, Wen-Chang Chang Nutrients.2015; 7(4): 2850. CrossRef - Ameliorative effects of lutein on non-alcoholic fatty liver disease in rats
Xiang Qiu World Journal of Gastroenterology.2015; 21(26): 8061. CrossRef - Histone hypoacetylation and increased histone deacetylases in peripheral blood mononuclear cells from patients with Graves' disease
Ni Yan, Jiao-zhen Zhou, Jin-an Zhang, Tiantian Cai, Wen Zhang, Yuan Wang, Fatuma-Said Muhali, Lijuan Guan, Rong-hua Song Molecular and Cellular Endocrinology.2015; 414: 143. CrossRef - Resveratrol relieves ischemia‑induced oxidative stress in the hippocampus by activating SIRT1
Zhuangzhi Meng, Jianguo Li, Honglin Zhao, Haiying Liu, Guowei Zhang, Lingzhan Wang, He Hu, Di Li, Mingjing Liu, Fulong Bi, Xiaoping Wang, Geng Tian, Qiang Liu, Batu Buren Experimental and Therapeutic Medicine.2015;[Epub] CrossRef - Could changes in adiponectin drive the effect of statins on the risk of new-onset diabetes? The case of pitavastatin
Lorenzo Arnaboldi, Alberto Corsini Atherosclerosis Supplements.2015; 16: 1. CrossRef - Obesity-Related Oxidative Stress: the Impact of Physical Activity and Diet Manipulation
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Mohamed H. Noureldein, Rania S. Abd El-Razek, Mohamed H. El-Hefnawy, Hala O. El-Mesallamy Diabetes Research and Clinical Practice.2015; 109(3): 513. CrossRef - Plasma levels of SIRT1 associate with non-alcoholic fatty liver disease in obese patients
Stefania Mariani, Daniela Fiore, Sabrina Basciani, Agnese Persichetti, Savina Contini, Carla Lubrano, Luisa Salvatori, Andrea Lenzi, Lucio Gnessi Endocrine.2015; 49(3): 711. CrossRef - Platycodon grandiflorum A. De Candolle Ethanolic Extract Inhibits Adipogenic Regulators in 3T3-L1 Cells and Induces Mitochondrial Biogenesis in Primary Brown Preadipocytes
Hye-Lin Kim, Jinbong Park, Hyewon Park, Yunu Jung, Dong-Hyun Youn, JongWook Kang, Mi-Young Jeong, Jae-Young Um Journal of Agricultural and Food Chemistry.2015; 63(35): 7721. CrossRef - Amazonian Fruits: An Overview of Nutrients, Calories and Use in Metabolic Disorders
Moacir Couto de Andrade Júnior, Jerusa Souza Andrade Food and Nutrition Sciences.2014; 05(17): 1692. CrossRef - Protective effects of resveratrol on postmenopausal osteoporosis: regulation of SIRT1-NF-κB signaling pathway
Jing Feng, Shuai Liu, Sai Ma, Jian Zhao, Wei Zhang, Wei Qi, Pengchong Cao, Zheng Wang, Wei Lei Acta Biochimica et Biophysica Sinica.2014; 46(12): 1024. CrossRef - The fat cell senescence hypothesis
Philip Newsholme, Paulo I. Homem de Bittencourt Current Opinion in Clinical Nutrition and Metabolic Care.2014; 17(4): 295. CrossRef - Sirt1 and Sirt6 Mediate Beneficial Effects of Rosiglitazone on Hepatic Lipid Accumulation
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