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Daisuke Koya  (Koya D) 2 Articles
Complications
Autophagy: A Novel Therapeutic Target for Diabetic Nephropathy
Shinji Kume, Daisuke Koya
Diabetes Metab J. 2015;39(6):451-460.   Published online December 11, 2015
DOI: https://doi.org/10.4093/dmj.2015.39.6.451
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  • 73 Crossref
AbstractAbstract PDFPubReader   

Diabetic nephropathy is a leading cause of end stage renal disease and its occurance is increasing worldwide. The most effective treatment strategy for the condition is intensive treatment to strictly control glycemia and blood pressure using renin-angiotensin system inhibitors. However, a fraction of patients still go on to reach end stage renal disease even under such intensive care. New therapeutic targets for diabetic nephropathy are, therefore, urgently needed. Autophagy is a major catabolic pathway by which mammalian cells degrade macromolecules and organelles to maintain intracellular homeostasis. The accumulation of damaged proteins and organelles is associated with the pathogenesis of diabetic nephropathy. Autophagy in the kidney is activated under some stress conditions, such as oxidative stress and hypoxia in proximal tubular cells, and occurs even under normal conditions in podocytes. These and other accumulating findings have led to a hypothesis that autophagy is involved in the pathogenesis of diabetic nephropathy. Here, we review recent findings underpinning this hypothesis and discuss the advantages of targeting autophagy for the treatment of diabetic nephropathy.

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SIRT1 in Type 2 Diabetes: Mechanisms and Therapeutic Potential
Munehiro Kitada, Daisuke Koya
Diabetes Metab J. 2013;37(5):315-325.   Published online October 17, 2013
DOI: https://doi.org/10.4093/dmj.2013.37.5.315
  • 5,993 View
  • 91 Download
  • 177 Crossref
AbstractAbstract PDFPubReader   

The prevalence of type 2 diabetes mellitus (T2DM) has been increasing worldwide. Therefore, a novel therapeutic strategy by which to prevent T2DM is urgently required. Calorie restriction (CR) can retard the aging processes, and delay the onset of numerous age-related diseases including diabetes. Metabolic CR mimetics may be therefore included as novel therapeutic targets for T2DM. Sirtuin 1 (SIRT1), a NAD+-dependent histone deacetylase that is induced by CR, is closely associated with lifespan elongation under CR. SIRT1 regulates glucose/lipid metabolism through its deacetylase activity on many substrates. SIRT1 in pancreatic β-cells positively regulates insulin secretion and protects cells from oxidative stress and inflammation, and has positive roles in the metabolic pathway via the modulation in insulin signaling. SIRT1 also regulates adiponectin secretion, inflammation, glucose production, oxidative stress, mitochondrial function, and circadian rhythms. Several SIRT1 activators, including resveratrol have been demonstrated to have beneficial effects on glucose homeostasis and insulin sensitivity in animal models of insulin resistance. Therefore, SIRT1 may be a novel therapeutic target for the prevention of T2DM, implicating with CR. In this review, we summarize current understanding of the biological functions of SIRT1 and discuss its potential as a promising therapeutic target for T2DM.

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    Robin Bonomi, Vadim Popov, Maxwell T. Laws, David Gelovani, Anjoy Majhi, Aleksandr Shavrin, Xin Lu, Otto Muzik, Nashaat Turkman, Renshyan Liu, Thomas Mangner, Juri G. Gelovani
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    Stéphanie Dal, Remmelt Van der Werf, Catherine Walter, William Bietiger, Elodie Seyfritz, Carole Mura, Claude Peronet, Julie Legrandois, Dalal Werner, Said Ennahar, Fabien Digel, Maillard-Pedracini Elisa, Michel Pinget, Nathalie Jeandidier, Eric Marchioni
    Oxidative Medicine and Cellular Longevity.2018; 2018: 1.     CrossRef
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    The Journal of Nutritional Biochemistry.2018; 57: 77.     CrossRef
  • Circulating soluble RAGE isoforms are attenuated in obese, impaired-glucose-tolerant individuals and are associated with the development of type 2 diabetes
    Edwin R. Miranda, Vikram S. Somal, Jacob T. Mey, Brian K. Blackburn, Edward Wang, Sarah Farabi, Kristian Karstoft, Ciaran E. Fealy, Sangeeta Kashyap, John P. Kirwan, Laurie Quinn, Thomas P. J. Solomon, Jacob M. Haus
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  • Fucoidan ameliorates pancreatic β‐cell death and impaired insulin synthesis in streptozotocin‐treated β cells and mice via a Sirt‐1‐dependent manner
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  • Tangshen formula improves inflammation in renal tissue of diabetic nephropathy through SIRT1/NF-κB pathway
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  • Overexpressed eNOS upregulates SIRT1 expression and protects mouse pancreatic β cells from apoptosis
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  • Resveratrol attenuates type 2 diabetes mellitus by mediating mitochondrial biogenesis and lipid metabolism via Sirtuin type 1
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  • SIRT1 attenuates neuropathic pain by epigenetic regulation of mGluR1/5 expressions in type 2 diabetic rats
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  • MiR-34a contributes to diabetes-related cochlear hair cell apoptosis via SIRT1/HIF-1α signaling
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  • Artesunate protects pancreatic beta cells against cytokine-induced damage via SIRT1 inhibiting NF-κB activation
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  • Sirt1 is essential for resveratrol enhancement of hypoxia-induced autophagy in the type 2 diabetic nephropathy rat
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  • 1,4-Dihydropyridines Active on the SIRT1/AMPK Pathway Ameliorate Skin Repair and Mitochondrial Function and Exhibit Inhibition of Proliferation in Cancer Cells
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  • DPP‐4 Inhibitor Linagliptin Attenuates Aβ‐induced Cytotoxicity through Activation of AMPK in Neuronal Cells
    Edy Kornelius, Chih‐Li Lin, Hsiu‐Han Chang, Hsin‐Hua Li, Wen‐Nung Huang, Yi‐Sun Yang, Ying‐Li Lu, Chiung‐Huei Peng, Chien‐Ning Huang
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  • Inhibition of microRNA-9-3p reduces lipid accumulation in HepG2 cells by targeting the expression of sirtuin type 1
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  • Bioinformatics analysis of abnormal DNA methylation in muscle samples from monozygotic twins discordant for type 2 diabetes
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  • Resveratrol Protects against Methylglyoxal-Induced Hyperglycemia and Pancreatic Damage In Vivo
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  • Obesity-Related Oxidative Stress: the Impact of Physical Activity and Diet Manipulation
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  • SIRT1 suppresses cardiomyocyte apoptosis in diabetic cardiomyopathy: An insight into endoplasmic reticulum stress response mechanism
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  • Fenofibrate reduces inflammation in obese patients with or without type 2 diabetes mellitus via sirtuin 1/fetuin A axis
    Mohamed H. Noureldein, Rania S. Abd El-Razek, Mohamed H. El-Hefnawy, Hala O. El-Mesallamy
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  • Plasma levels of SIRT1 associate with non-alcoholic fatty liver disease in obese patients
    Stefania Mariani, Daniela Fiore, Sabrina Basciani, Agnese Persichetti, Savina Contini, Carla Lubrano, Luisa Salvatori, Andrea Lenzi, Lucio Gnessi
    Endocrine.2015; 49(3): 711.     CrossRef
  • Platycodon grandiflorum A. De Candolle Ethanolic Extract Inhibits Adipogenic Regulators in 3T3-L1 Cells and Induces Mitochondrial Biogenesis in Primary Brown Preadipocytes
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  • Protective effects of resveratrol on postmenopausal osteoporosis: regulation of SIRT1-NF-κB signaling pathway
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  • The fat cell senescence hypothesis
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  • Sirt1 and Sirt6 Mediate Beneficial Effects of Rosiglitazone on Hepatic Lipid Accumulation
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  • Role of SIRT1 in Streptococcus pneumoniae-induced human β-defensin-2 and interleukin-8 expression in A549 cell
    Li Lin, Shun-hang Wen, Shu-zhen Guo, Xiao-yan Su, Hu-jun Wu, Lei Chong, Hai-lin Zhang, Wei-xi Zhang, Chang-chong Li
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Diabetes Metab J : Diabetes & Metabolism Journal